rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BFAR(1), BRAF(147), CAMP(1), CREB3(1), CREB5(11), MAPK1(4), RAF1(8), SNX13(1), SRC(1), TERF2IP(2) 4346750 177 155 48 31 31 4 7 131 4 0 0.00294 1.68e-12 1.03e-09 2 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CCND1(1), CDK4(5), CDKN1A(4), CDKN1B(1), CDKN2A(34), CFL1(1), E2F1(7), E2F2(4), MDM2(4), NXT1(2), PRB1(34), TP53(43) 3283462 140 88 108 17 69 4 8 17 42 0 1.38e-10 2.16e-05 0.00664 3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(18), CCND1(1), CCNE1(4), CCNE2(14), CDK4(5), CDKN1B(1), CDKN2A(34), E2F1(7), E2F2(4), E2F4(1), PRB1(34) 3498413 123 84 95 18 71 0 6 20 26 0 1.52e-07 0.0292 1.000 4 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(10) 279111 10 10 10 2 7 1 1 1 0 0 0.124 0.160 1.000 5 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(12), CDKN2A(34), E2F1(7), MDM2(4), MYC(5), PIK3CA(9), PIK3R1(7), POLR1A(11), POLR1B(9), POLR1C(1), RAC1(17), RB1(8), TBX2(6), TP53(43), TWIST1(1) 7859836 174 108 137 25 87 9 9 18 48 3 7.16e-11 0.434 1.000 6 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(4) 200024 4 4 4 1 4 0 0 0 0 0 0.482 0.533 1.000 7 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(4), FOSB(6), GRIA2(38), JUND(1), PPP1R1B(2) 1422676 51 43 48 16 33 3 2 6 7 0 0.0378 0.767 1.000 8 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(1), MYC(5), SP1(5), SP3(1), TP53(43), WT1(6) 2756180 61 49 52 11 27 3 7 6 18 0 0.00231 0.848 1.000 9 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(2), LIPT1(3) 601922 5 4 5 0 0 2 1 1 1 0 0.208 0.901 1.000 10 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(6), GOT2(7), TAT(17) 1024012 30 20 29 8 23 2 2 1 2 0 0.0153 0.933 1.000 11 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(6), DCN(17), FMOD(5), KERA(15), LUM(12) 1368273 55 41 51 18 44 4 3 1 3 0 0.00241 0.936 1.000 12 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(5) 644527 5 5 3 1 4 0 0 1 0 0 0.270 0.963 1.000 13 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(5), CHRNA1(5), SNAP25(6), STX1A(3) 1271830 19 16 16 4 13 1 0 1 4 0 0.0157 0.978 1.000 14 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(4), IL8(1), SLPI(7) 668513 12 12 12 5 6 1 0 4 1 0 0.490 0.991 1.000 15 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(5), ALDOA(2), ALDOB(13), ALDOC(3) 1534583 23 18 19 5 18 2 0 1 2 0 0.0101 0.993 1.000 16 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(5), CD3E(2), CD3G(1) 437385 8 6 8 5 7 0 0 0 1 0 0.701 0.996 1.000 17 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(2), DNAJC3(2), EIF2S1(1), MAP3K14(4), NFKB1(7), NFKBIA(2), RELA(5), TP53(43) 3761973 66 56 57 14 30 6 5 8 17 0 0.00496 0.998 1.000 18 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(6), ATM(13), BAX(3), BCL2(2), CCND1(1), CCNE1(4), CDK4(5), CDKN1A(4), E2F1(7), MDM2(4), PCNA(2), RB1(8), TIMP3(5), TP53(43) 6997545 107 78 96 21 41 8 9 19 28 2 0.000488 0.999 1.000 19 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(2), BCKDK(2), CBS(7), CTH(1), MUT(7) 1975908 19 19 18 6 12 2 1 3 1 0 0.225 1.000 1.000 20 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(3), IDI1(1), SQLE(5) 1234896 9 9 9 3 5 1 1 2 0 0 0.383 1.000 1.000 21 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(2), CASP3(2), CASP8(9), CFL1(1), CFLAR(4), PDE6D(2) 1519563 20 18 19 8 9 1 2 6 2 0 0.553 1.000 1.000 22 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(2), NFYB(3), NFYC(2), RB1(8), SP1(5), SP3(1) 2592449 21 18 21 6 3 2 3 6 5 2 0.355 1.000 1.000 23 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(5), ALDH1A2(12), BCMO1(17), RDH5(2) 1518207 36 32 33 13 25 2 1 4 4 0 0.0549 1.000 1.000 24 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(14), GAD1(15), HDC(22), PNMT(4), TH(9), TPH1(9) 2315032 73 54 69 27 59 3 2 4 5 0 0.00223 1.000 1.000 25 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), GALT(2), TGDS(1), UGDH(1), UXS1(4) 1501633 9 9 9 9 4 0 1 0 4 0 0.972 1.000 1.000 26 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(5), ACTR2(3), ACTR3(2), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(3), RAC1(17), WASF1(5), WASL(5) 3158609 47 41 38 10 33 3 1 6 4 0 0.0103 1.000 1.000 27 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(4), ACADM(6), ACADS(4), ECHS1(2), HADHA(8) 2133142 24 22 24 7 14 2 1 7 0 0 0.244 1.000 1.000 28 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(5), BRAF(147), CREB3(1), CREB5(11), DUSP4(3), DUSP6(1), DUSP9(3), EEF2K(7), EIF4E(1), GRB2(2), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK3(1), MKNK1(5), MKNK2(2), MOS(5), NFKB1(7), RAP1A(2), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), SHC1(3), SOS1(9), SOS2(13), TRAF3(5) 11402151 273 181 134 67 99 12 12 141 9 0 0.000887 1.000 1.000 29 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(5), IFNG(2), IL12A(3), IL12B(4), IL18(2), IL2(4) 1145362 20 10 19 8 14 2 0 2 2 0 0.248 1.000 1.000 30 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCR3(11), CSF2(2), HLA-DRA(11), HLA-DRB1(4), IL3(3), IL5(4) 1176397 36 28 35 16 29 2 0 3 2 0 0.0444 1.000 1.000 31 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(18), CCND1(1), CCND2(5), CCND3(2), CCNE1(4), CCNH(2), CDC25A(8), CDK4(5), CDK6(3), CDKN1A(4), CDKN1B(1), CDKN2A(34), CDKN2C(1), E2F1(7), RB1(8), RBL1(11), TFDP1(3) 6272750 117 82 97 26 58 3 7 17 30 2 4.41e-05 1.000 1.000 32 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(4), CDC34(4), CUL1(7), E2F1(7), FBXW7(12), RB1(8), TFDP1(3) 3163515 45 37 44 12 21 3 5 6 8 2 0.0433 1.000 1.000 33 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 CAMP(1), DAG1(6), GNAQ(5), ITPKA(1), ITPKB(6) 2330897 19 19 19 7 12 1 1 2 3 0 0.189 1.000 1.000 34 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(4), MMP14(2), MMP2(7), MMP9(8), RECK(13), TIMP1(1), TIMP2(1), TIMP3(5), TIMP4(6) 2886289 47 39 45 15 27 3 3 10 4 0 0.0561 1.000 1.000 35 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(4), MTMR2(3), MTMR6(2), NFS1(3), TPK1(9) 2486053 22 20 21 7 15 1 2 1 2 1 0.287 1.000 1.000 36 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(5), AASDHPPT(3), AASS(4), KARS(6) 1809763 18 18 18 5 15 0 1 2 0 0 0.229 1.000 1.000 37 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(1), ECHS1(2), EHHADH(7), GCDH(5), HADHA(8), SDHB(1), SDS(2) 3034624 26 22 25 8 18 3 0 4 1 0 0.105 1.000 1.000 38 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(3), HLCS(7) 1203195 10 10 10 9 7 0 1 1 1 0 0.874 1.000 1.000 39 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(8), SEC61A2(8), SRP19(6), SRP54(3), SRP68(7), SRP72(1), SRP9(1), SRPR(2) 2974087 36 30 31 10 15 0 3 11 7 0 0.292 1.000 1.000 40 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(1), HMGCL(4), OXCT1(5) 1309193 10 10 10 5 7 1 0 1 1 0 0.648 1.000 1.000 41 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(11), LPL(3), NR3C1(7), PPARG(11), RETN(3), RXRA(4), TNF(1) 2264302 40 32 38 14 27 2 0 6 5 0 0.0643 1.000 1.000 42 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(18), CCNE1(4), CDC34(4), CUL1(7), E2F1(7), RB1(8), SKP2(2), TFDP1(3) 3306222 53 43 52 15 32 3 4 7 5 2 0.0197 1.000 1.000 43 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(2), GLS2(3), GLUD1(2), GLUD2(4) 1765042 11 9 11 7 3 3 1 1 3 0 0.801 1.000 1.000 44 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(8), CDC25B(6), CDKN1A(4), CHEK1(2), NEK1(9), WEE1(3) 2693558 32 26 32 8 15 6 1 5 5 0 0.157 1.000 1.000 45 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(5), B3GNT1(2), FUT1(3), FUT2(3), FUT9(25), ST8SIA1(1) 2324565 39 36 38 17 30 3 2 4 0 0 0.0955 1.000 1.000 46 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(11), IARS(8), LARS(10), LARS2(5), PDHA1(3), PDHA2(19), PDHB(1) 3913217 57 42 52 13 39 6 1 6 5 0 0.0103 1.000 1.000 47 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(4), DPM2(1), EGR1(4), HRAS(4), KLK2(2), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK3(1), NGFR(8), RAF1(8) 3145509 53 47 44 23 30 4 2 10 7 0 0.130 1.000 1.000 48 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(5), RAB11A(1), RAB1A(1), RAB27A(3), RAB3A(2), RAB5A(1) 1638960 13 11 13 7 10 1 1 1 0 0 0.557 1.000 1.000 49 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(2), ECHS1(2), HADHA(8), HADHB(4), HSD17B10(2), HSD17B4(6), MECR(6), PPT1(4), PPT2(8) 3297276 42 40 40 14 18 4 4 13 3 0 0.226 1.000 1.000 50 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH6(11), ADH7(13), ADHFE1(6) 2192567 116 77 95 36 91 8 5 9 3 0 0.00130 1.000 1.000 51 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(4), PLCD1(4), PRKCA(11), TGM2(9) 1930848 28 21 27 11 22 2 0 0 4 0 0.0320 1.000 1.000 52 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(5), PSMA2(1), PSMA4(2), PSMA5(4), PSMA6(4), PSMB1(1), PSMB10(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMB8(5) 3426027 29 23 29 9 15 2 2 6 4 0 0.274 1.000 1.000 53 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(16), NR0B2(6), NR1H3(3), NR1H4(15), RXRA(4) 2111130 44 32 44 16 29 7 3 2 3 0 0.0226 1.000 1.000 54 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(3), GGPS1(1), IDI1(1), IDI2(1), SQLE(5) 1651426 11 11 11 5 7 1 1 2 0 0 0.505 1.000 1.000 55 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(12), GOT1(6), GOT2(7), TAT(17), TYR(8) 1827319 50 32 49 22 38 4 3 1 4 0 0.142 1.000 1.000 56 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(5), AASDH(5), AASDHPPT(3), AASS(4), KARS(6) 2683306 23 21 23 7 19 0 1 2 1 0 0.255 1.000 1.000 57 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(4), CDKN1B(1), CUL1(7), E2F1(7), NEDD8(1), RB1(8), SKP2(2), TFDP1(3), UBE2M(1) 3337034 34 33 34 12 15 3 4 4 6 2 0.170 1.000 1.000 58 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(3), AKT2(8), AKT3(4), CDKN1A(4), ELK1(2), GRB2(2), HRAS(4), MAP2K1(13), MAP2K2(4), NGFR(8), NTRK1(19), PIK3CA(9), PIK3CD(7), SHC1(3), SOS1(9) 6185015 99 71 89 29 50 15 3 20 11 0 0.00802 1.000 1.000 59 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(6), BAX(3), BCL10(3), BCL2(2), BCL2L11(5), CASP8AP2(9), CASP9(3), CES1(16) 4188707 47 34 46 13 29 6 2 3 7 0 0.0659 1.000 1.000 60 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(3), ECHS1(2), EHHADH(7), HADHA(8), SDS(2) 1880816 22 20 20 10 14 2 0 5 1 0 0.361 1.000 1.000 61 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(3), ACP2(2), ACP5(3), ACPP(8), ACPT(1), ENPP1(13), ENPP3(15), FLAD1(9), TYR(8) 3750593 62 46 60 19 37 7 3 6 9 0 0.0397 1.000 1.000 62 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(10), CTH(1), GOT1(6), GOT2(7), LDHA(6), LDHB(2), LDHC(5), MPST(2) 2668695 39 30 36 15 29 1 5 2 2 0 0.134 1.000 1.000 63 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(2), NDUFA4(1), NDUFB2(4), NDUFB5(3), NDUFB6(2), NDUFS2(2), NDUFV1(2) 2718775 16 16 16 6 10 0 2 3 1 0 0.489 1.000 1.000 64 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(1), CSF1(11), IL6(2), LDLR(16), LPL(3) 2081416 33 23 33 15 24 3 2 3 1 0 0.207 1.000 1.000 65 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), CYCS(1), GPD2(2), SDHA(3), SDHB(1), SDHC(3), SDHD(1), UQCRC1(3) 2585249 15 15 15 7 11 0 1 1 2 0 0.509 1.000 1.000 66 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(3), ACTR3(2), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(3), PAK1(4), PDGFRA(32), PIK3CA(9), PIK3R1(7), RAC1(17), WASL(5) 5219468 89 65 79 27 56 5 4 12 11 1 0.0419 1.000 1.000 67 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(10), CS(2), MDH1(1), ME1(20), PC(13), PDHA1(3), SLC25A11(2) 3617435 51 37 50 21 29 6 2 10 4 0 0.0971 1.000 1.000 68 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(3), PAPSS2(5), SULT1A2(4), SULT1E1(16), SULT2A1(8), SUOX(5) 2370299 41 25 39 14 32 2 0 2 5 0 0.0821 1.000 1.000 69 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(12), CDO1(6), CSAD(4), GAD1(15), GAD2(10), GGT1(7) 2197674 54 42 53 26 37 4 4 7 2 0 0.229 1.000 1.000 70 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(4), ENO2(4), ENO3(4), FARS2(5), GOT1(6), GOT2(7), PAH(9), TAT(17), YARS(1) 3243541 57 42 54 25 43 5 2 4 3 0 0.0560 1.000 1.000 71 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(3), APEX1(1), CREBBP(23), DFFA(2), DFFB(3), GZMA(11), GZMB(3), HMGB2(1), PRF1(13), SET(3) 4115308 63 44 61 20 37 4 5 11 6 0 0.0670 1.000 1.000 72 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(3), ACP2(2), ACP5(3), ACP6(11), ACPP(8), ACPT(1), ENPP1(13), ENPP3(15), FLAD1(9), LHPP(1), MTMR1(4), MTMR2(3), MTMR6(2), TYR(8) 5819641 83 56 80 23 49 8 7 8 11 0 0.00941 1.000 1.000 73 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(4), IFNG(2), IFNGR1(4), IFNGR2(4), IKBKB(4), JAK2(9), LIN7A(13), NFKB1(7), NFKBIA(2), RB1(8), RELA(5), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TP53(43), USH1C(18), WT1(6) 7009380 136 85 122 37 64 7 8 19 36 2 0.00167 1.000 1.000 74 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(5), ACO2(5), FH(3), IDH1(15), IDH2(2), MDH1(1), MDH2(4), SDHB(1) 3484907 36 29 23 15 26 1 2 4 3 0 0.186 1.000 1.000 75 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(3), ACVR1C(9), AKT1(3), AKT2(8), AKT3(4), ARRB1(3), ARRB2(6), ATF2(5), ATF4(7), BDNF(5), BRAF(147), CACNA1A(36), CACNA1B(28), CACNA1C(46), CACNA1D(34), CACNA1E(101), CACNA1F(21), CACNA1G(30), CACNA1H(26), CACNA1I(34), CACNA1S(48), CACNA2D1(14), CACNA2D2(15), CACNA2D3(49), CACNA2D4(19), CACNB1(4), CACNB2(13), CACNB3(2), CACNB4(11), CACNG1(3), CACNG2(9), CACNG3(20), CACNG4(3), CACNG5(12), CACNG6(6), CACNG7(6), CACNG8(1), CASP3(2), CD14(5), CDC25B(6), CDC42(3), CHP(3), CHUK(2), CRK(3), CRKL(2), DAXX(10), DDIT3(2), DUSP10(6), DUSP14(2), DUSP16(5), DUSP2(1), DUSP3(2), DUSP4(3), DUSP5(2), DUSP6(1), DUSP7(2), DUSP8(4), DUSP9(3), ECSIT(4), EGF(19), EGFR(23), ELK1(2), ELK4(7), FAS(5), FASLG(14), FGF1(1), FGF10(2), FGF11(2), FGF12(12), FGF13(8), FGF14(5), FGF16(8), FGF17(2), FGF18(2), FGF19(3), FGF2(2), FGF21(4), FGF23(8), FGF3(5), FGF4(2), FGF5(5), FGF6(6), FGF7(7), FGF8(1), FGF9(4), FGFR1(11), FGFR2(32), FGFR3(10), FGFR4(10), FLNA(15), FLNB(43), FLNC(60), FOS(2), GADD45B(2), GADD45G(1), GNA12(3), GRB2(2), HRAS(4), IKBKB(4), IL1A(4), IL1B(7), IL1R1(12), IL1R2(9), JUN(1), JUND(1), KRAS(4), MAP2K1(13), MAP2K2(4), MAP2K3(9), MAP2K4(4), MAP2K5(3), MAP2K6(3), MAP2K7(4), MAP3K1(3), MAP3K10(8), MAP3K12(4), MAP3K13(10), MAP3K14(4), MAP3K2(6), MAP3K3(6), MAP3K4(16), MAP3K5(18), MAP3K6(6), MAP3K7(1), MAP4K1(9), MAP4K2(6), MAP4K3(8), MAP4K4(8), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(2), MAPK13(5), MAPK14(5), MAPK3(1), MAPK7(4), MAPK8(2), MAPK8IP1(5), MAPK8IP2(9), MAPK8IP3(9), MAPK9(7), MAPKAPK2(5), MAPKAPK3(4), MAPKAPK5(1), MAPT(12), MEF2C(3), MKNK1(5), MKNK2(2), MOS(5), MRAS(2), MYC(5), NF1(47), NFATC2(9), NFATC4(13), NFKB1(7), NFKB2(5), NLK(6), NR4A1(4), NRAS(73), NTF3(6), NTRK1(19), NTRK2(9), PAK1(4), PAK2(8), PDGFA(1), PDGFB(4), PDGFRA(32), PDGFRB(18), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(7), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), PPM1A(3), PPM1B(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(8), PPP5C(2), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(11), PRKCG(14), PRKX(4), PTPN5(12), PTPN7(3), PTPRR(26), RAC1(17), RAC2(1), RAF1(8), RAP1A(2), RAP1B(1), RAPGEF2(10), RASA1(4), RASA2(15), RASGRF1(23), RASGRF2(20), RASGRP1(9), RASGRP2(7), RASGRP3(15), RASGRP4(11), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), RPS6KA4(4), RPS6KA5(4), RPS6KA6(16), RRAS(1), SOS1(9), SOS2(13), SRF(2), STK4(3), STMN1(3), TAOK1(12), TAOK2(25), TAOK3(4), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(7), TNF(1), TNFRSF1A(3), TP53(43), TRAF2(3), TRAF6(5), ZAK(7) 109301390 2299 253 1994 1189 1380 193 108 396 217 5 0.0117 1.000 1.000 76 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ACTN1(5), ACTN2(24), ACTN3(7), ACTN4(5), APC(22), APC2(9), ARAF(5), ARHGEF1(1), ARHGEF12(12), ARHGEF4(6), ARHGEF6(10), ARHGEF7(4), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), ARPC5(1), BAIAP2(7), BCAR1(5), BDKRB1(5), BDKRB2(10), BRAF(147), CD14(5), CDC42(3), CFL1(1), CHRM1(5), CHRM2(19), CHRM3(22), CHRM4(6), CHRM5(4), CRK(3), CRKL(2), CSK(1), CYFIP1(7), CYFIP2(24), DIAPH1(6), DIAPH2(7), DIAPH3(12), DOCK1(15), EGF(19), EGFR(23), EZR(1), F2(9), F2R(7), FGD1(4), FGD3(8), FGF1(1), FGF10(2), FGF11(2), FGF12(12), FGF13(8), FGF14(5), FGF16(8), FGF17(2), FGF18(2), FGF19(3), FGF2(2), FGF21(4), FGF23(8), FGF3(5), FGF4(2), FGF5(5), FGF6(6), FGF7(7), FGF8(1), FGF9(4), FGFR1(11), FGFR2(32), FGFR3(10), FGFR4(10), FN1(25), GIT1(4), GNA12(3), GNA13(1), GRLF1(12), GSN(6), HRAS(4), IQGAP1(10), IQGAP2(24), IQGAP3(11), ITGA1(18), ITGA10(10), ITGA11(17), ITGA2(14), ITGA2B(11), ITGA3(7), ITGA4(38), ITGA5(25), ITGA6(8), ITGA7(25), ITGA8(36), ITGA9(14), ITGAD(26), ITGAE(19), ITGAL(24), ITGAM(21), ITGAV(9), ITGAX(20), ITGB1(4), ITGB2(14), ITGB3(12), ITGB4(22), ITGB5(7), ITGB6(12), ITGB7(6), ITGB8(17), KRAS(4), LIMK1(4), LIMK2(9), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK3(1), MOS(5), MRAS(2), MSN(1), MYH10(13), MYH14(17), MYH9(12), MYL2(5), MYL5(1), MYL7(2), MYL9(2), MYLK(41), MYLK2(13), MYLPF(2), NCKAP1(7), NCKAP1L(33), NRAS(73), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PAK7(48), PDGFA(1), PDGFB(4), PDGFRA(32), PDGFRB(18), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PIP4K2A(5), PIP4K2B(3), PIP4K2C(3), PIP5K1A(6), PIP5K1B(20), PIP5K1C(8), PPP1CA(2), PPP1CB(5), PPP1CC(2), PPP1R12A(5), PPP1R12B(8), PTK2(8), PXN(3), RAC1(17), RAC2(1), RAF1(8), RDX(1), RHOA(1), ROCK1(5), ROCK2(13), RRAS(1), SCIN(8), SLC9A1(4), SOS1(9), SOS2(13), SSH1(14), SSH2(8), SSH3(3), TIAM1(27), TIAM2(29), TMSL3(2), VAV1(16), VAV2(4), VAV3(10), VCL(7), WAS(7), WASF1(5), WASF2(5), WASL(5) 106408273 1991 250 1713 912 1204 115 97 403 168 4 7.33e-06 1.000 1.000 77 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(7), ACTG1(5), ACTN1(5), ACTN2(24), ACTN3(7), ACTN4(5), AKT1(3), AKT2(8), AKT3(4), ARHGAP5(12), BCAR1(5), BCL2(2), BIRC2(5), BIRC3(8), BRAF(147), CAPN2(6), CAV1(2), CCND1(1), CCND2(5), CCND3(2), CDC42(3), CHAD(4), COL11A1(65), COL11A2(40), COL1A1(44), COL1A2(42), COL2A1(30), COL3A1(72), COL4A1(62), COL4A2(33), COL4A4(97), COL4A6(35), COL5A1(65), COL5A2(45), COL5A3(71), COL6A1(9), COL6A2(21), COL6A3(60), COL6A6(59), COMP(7), CRK(3), CRKL(2), CTNNB1(13), DIAPH1(6), DOCK1(15), EGF(19), EGFR(23), ELK1(2), ERBB2(7), FARP2(6), FIGF(4), FLNA(15), FLNB(43), FLNC(60), FLT1(33), FN1(25), FYN(7), GRB2(2), GRLF1(12), GSK3B(2), HGF(24), HRAS(4), IBSP(8), IGF1(11), IGF1R(11), ITGA1(18), ITGA10(10), ITGA11(17), ITGA2(14), ITGA2B(11), ITGA3(7), ITGA4(38), ITGA5(25), ITGA6(8), ITGA7(25), ITGA8(36), ITGA9(14), ITGAV(9), ITGB1(4), ITGB3(12), ITGB4(22), ITGB5(7), ITGB6(12), ITGB7(6), ITGB8(17), JUN(1), KDR(45), LAMA1(42), LAMA2(59), LAMA3(62), LAMA4(11), LAMA5(29), LAMB1(10), LAMB2(11), LAMB3(27), LAMB4(40), LAMC1(10), LAMC2(21), LAMC3(7), MAP2K1(13), MAPK1(4), MAPK10(9), MAPK3(1), MAPK8(2), MAPK9(7), MET(23), MYL2(5), MYL5(1), MYL7(2), MYL9(2), MYLK(41), MYLK2(13), MYLPF(2), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PAK7(48), PARVA(2), PARVB(3), PARVG(4), PDGFA(1), PDGFB(4), PDGFC(18), PDGFD(7), PDGFRA(32), PDGFRB(18), PDPK1(4), PGF(1), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PIP5K1C(8), PPP1CA(2), PPP1CB(5), PPP1CC(2), PPP1R12A(5), PRKCA(11), PRKCG(14), PTEN(23), PTK2(8), PXN(3), RAC1(17), RAC2(1), RAF1(8), RAP1A(2), RAP1B(1), RAPGEF1(10), RELN(76), RHOA(1), ROCK1(5), ROCK2(13), SHC1(3), SHC2(7), SHC3(12), SHC4(2), SOS1(9), SOS2(13), SPP1(7), SRC(1), THBS1(30), THBS2(10), THBS3(11), THBS4(11), TLN1(14), TLN2(25), TNC(32), TNN(46), TNR(76), TNXB(143), VASP(3), VAV1(16), VAV2(4), VAV3(10), VCL(7), VEGFA(7), VEGFB(1), VEGFC(19), VTN(7), VWF(51), ZYX(7) 143618917 3363 246 3078 1375 2322 218 104 442 274 3 6.62e-12 1.000 1.000 78 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(5), BRAF(147), C7orf16(1), CACNA1A(36), CRH(3), CRHR1(7), GNA11(7), GNA12(3), GNA13(1), GNAI1(1), GNAI2(5), GNAI3(3), GNAO1(2), GNAQ(5), GNAS(22), GNAZ(6), GRIA1(45), GRIA2(38), GRIA3(23), GRID2(52), GRM1(17), GRM5(15), GUCY1A2(21), GUCY1A3(34), GUCY1B3(7), GUCY2C(32), GUCY2D(10), GUCY2F(16), HRAS(4), IGF1(11), IGF1R(11), ITPR1(36), ITPR2(18), ITPR3(9), KRAS(4), LYN(7), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK3(1), NOS1(65), NOS3(17), NPR1(18), NPR2(14), NRAS(73), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(7), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(4), PPP2R2A(2), PPP2R2B(6), PPP2R2C(6), PRKCA(11), PRKCG(14), PRKG1(13), PRKG2(16), RAF1(8), RYR1(93) 42302442 1256 245 976 595 763 70 66 270 86 1 7.34e-05 1.000 1.000 79 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(5), BRAF(147), CASP3(2), CD244(9), CD247(3), CD48(5), CHP(3), CSF2(2), FAS(5), FASLG(14), FCER1G(1), FCGR3A(9), FCGR3B(3), FYN(7), GRB2(2), GZMB(3), HLA-A(3), HLA-B(5), HLA-C(1), HLA-E(1), HLA-G(4), HRAS(4), ICAM1(3), ICAM2(4), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(10), IFNA17(2), IFNA2(1), IFNA21(9), IFNA4(1), IFNA5(3), IFNA6(3), IFNA7(5), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IFNG(2), IFNGR1(4), IFNGR2(4), ITGAL(24), ITGB2(14), KIR2DL1(21), KIR2DL3(6), KIR2DL4(4), KIR3DL1(18), KIR3DL2(2), KLRC1(5), KLRC2(1), KLRC3(11), KLRD1(5), KLRK1(5), KRAS(4), LAT(1), LCK(14), LCP2(10), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK3(1), MICA(4), MICB(4), NCR1(13), NCR2(11), NCR3(3), NFAT5(8), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NRAS(73), PAK1(4), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PLCG1(9), PLCG2(25), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(8), PRF1(13), PRKCA(11), PRKCG(14), PTK2B(11), PTPN11(10), PTPN6(3), RAC1(17), RAC2(1), RAF1(8), SH2D1A(2), SH2D1B(3), SH3BP2(2), SHC1(3), SHC2(7), SHC3(12), SHC4(2), SOS1(9), SOS2(13), SYK(16), TNF(1), TNFRSF10A(5), TNFRSF10B(3), TNFRSF10C(4), TNFRSF10D(8), TNFSF10(8), TYROBP(5), ULBP1(2), ULBP3(5), VAV1(16), VAV2(4), VAV3(10), ZAP70(7) 43669952 1033 243 791 386 561 58 64 276 73 1 1.76e-06 1.000 1.000 80 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(21), ADORA1(6), ADORA2A(2), ADORA2B(3), ADORA3(12), ADRA1A(10), ADRA1B(4), ADRA2A(3), ADRA2B(9), ADRA2C(2), ADRB1(5), ADRB2(2), AGTR1(11), AGTR2(12), AVPR1A(4), AVPR1B(9), AVPR2(1), BDKRB1(5), BDKRB2(10), BRS3(5), C3AR1(5), C5AR1(9), CALCR(17), CALCRL(15), CCKAR(10), CCKBR(12), CGA(1), CHRM1(5), CHRM2(19), CHRM3(22), CHRM4(6), CHRM5(4), CNR1(9), CNR2(4), CRHR1(7), CRHR2(4), CTSG(4), CYSLTR1(5), CYSLTR2(4), DRD1(11), DRD2(17), DRD3(6), DRD4(1), DRD5(23), EDNRA(9), EDNRB(5), F2(9), F2R(7), F2RL1(16), F2RL2(6), F2RL3(3), FPR1(20), FSHB(4), FSHR(19), GABBR1(8), GABBR2(10), GABRA1(16), GABRA2(16), GABRA3(19), GABRA4(13), GABRA5(3), GABRA6(24), GABRB1(16), GABRB2(20), GABRB3(19), GABRD(5), GABRE(20), GABRG1(29), GABRG2(15), GABRG3(7), GABRP(14), GABRQ(11), GABRR1(8), GABRR2(1), GALR1(5), GALR2(1), GALR3(2), GH1(3), GH2(10), GHR(30), GHRHR(4), GHSR(11), GIPR(2), GLP1R(11), GLP2R(14), GLRA1(12), GLRA2(6), GLRA3(14), GLRB(29), GNRHR(2), GPR156(10), GPR35(3), GPR50(20), GPR63(6), GPR83(14), GRIA1(45), GRIA2(38), GRIA3(23), GRIA4(24), GRID1(24), GRID2(52), GRIK1(23), GRIK2(21), GRIK3(30), GRIK4(13), GRIK5(12), GRIN1(7), GRIN2A(91), GRIN2B(56), GRIN2C(8), GRIN2D(6), GRIN3A(42), GRIN3B(5), GRM1(17), GRM2(9), GRM3(54), GRM4(20), GRM5(15), GRM6(27), GRM7(39), GRM8(50), GRPR(5), GZMA(11), HCRTR1(3), HCRTR2(29), HRH1(18), HRH2(4), HRH3(4), HRH4(5), HTR1A(8), HTR1B(1), HTR1D(3), HTR1E(6), HTR1F(8), HTR2A(9), HTR2B(2), HTR2C(12), HTR4(10), HTR5A(17), HTR6(1), HTR7(8), LEP(2), LEPR(25), LHCGR(27), LTB4R(1), LTB4R2(1), MAS1(4), MC2R(5), MC3R(7), MC4R(1), MC5R(7), MCHR1(4), MCHR2(17), MLNR(1), MTNR1A(8), MTNR1B(7), NMBR(8), NMUR1(6), NMUR2(15), NPBWR1(2), NPBWR2(12), NPFFR1(1), NPFFR2(12), NPY1R(25), NPY2R(14), NPY5R(24), NR3C1(7), NTSR1(6), NTSR2(3), OPRD1(2), OPRK1(23), OPRL1(5), OPRM1(5), OXTR(5), P2RX1(4), P2RX2(3), P2RX3(10), P2RX4(2), P2RX5(8), P2RX7(5), P2RY1(4), P2RY10(7), P2RY13(4), P2RY14(9), P2RY2(8), P2RY6(1), P2RY8(8), PARD3(17), PPYR1(12), PRL(1), PRLHR(2), PRLR(30), PRSS1(27), PRSS3(4), PTAFR(2), PTGDR(9), PTGER2(6), PTGER3(3), PTGER4(1), PTGFR(22), PTGIR(6), PTH2R(16), RXFP1(19), RXFP2(24), SCTR(10), SSTR1(11), SSTR2(6), SSTR3(12), SSTR4(4), SSTR5(3), TAAR1(2), TAAR2(9), TAAR5(4), TAAR6(11), TAAR8(7), TAAR9(3), TACR1(8), TACR2(8), TACR3(28), TBXA2R(4), THRA(4), THRB(17), TRHR(21), TRPV1(2), TSHB(7), TSHR(11), UTS2R(1), VIPR1(4), VIPR2(5) 85072129 2620 240 2418 1602 1835 227 92 241 223 2 5.40e-10 1.000 1.000 81 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(29), ADCY8(51), ARAF(5), ATF4(7), BRAF(147), CACNA1C(46), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CAMK4(12), CHP(3), CREBBP(23), EP300(14), GNAQ(5), GRIA1(45), GRIA2(38), GRIN1(7), GRIN2A(91), GRIN2B(56), GRIN2C(8), GRIN2D(6), GRM1(17), GRM5(15), HRAS(4), ITPR1(36), ITPR2(18), ITPR3(9), KRAS(4), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK3(1), NRAS(73), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), PPP1CA(2), PPP1CB(5), PPP1CC(2), PPP1R12A(5), PPP1R1A(4), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(8), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(11), PRKCG(14), PRKX(4), RAF1(8), RAP1A(2), RAP1B(1), RAPGEF3(13), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), RPS6KA6(16) 38098065 1104 240 844 512 631 70 67 268 67 1 0.000840 1.000 1.000 82 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(21), ACACB(21), AKT1(3), AKT2(8), AKT3(4), ARAF(5), BRAF(147), CALM1(1), CALM2(1), CALML3(6), CBL(11), CBLB(19), CBLC(15), CRK(3), CRKL(2), EIF4EBP1(1), ELK1(2), EXOC7(8), FASN(17), FBP1(2), FBP2(2), FLOT1(2), FOXO1(6), G6PC(7), G6PC2(7), GCK(20), GRB2(2), GSK3B(2), GYS1(3), GYS2(22), HRAS(4), IKBKB(4), INPP5D(37), INSR(22), IRS1(6), IRS2(2), IRS4(12), KRAS(4), LIPE(9), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK10(9), MAPK3(1), MAPK8(2), MAPK9(7), MKNK1(5), MKNK2(2), NRAS(73), PCK1(23), PCK2(4), PDE3A(27), PDE3B(6), PDPK1(4), PFKL(4), PFKM(2), PHKA1(23), PHKA2(7), PHKB(7), PHKG1(1), PHKG2(2), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PKLR(11), PKM2(5), PPARGC1A(22), PPP1CA(2), PPP1CB(5), PPP1CC(2), PPP1R3A(62), PPP1R3B(6), PPP1R3C(3), PPP1R3D(3), PRKAA1(1), PRKAA2(26), PRKAB1(2), PRKAB2(2), PRKACA(4), PRKACB(4), PRKACG(8), PRKAG1(2), PRKAG2(9), PRKAG3(10), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCI(8), PRKCZ(6), PRKX(4), PTPN1(4), PTPRF(28), PYGB(2), PYGL(9), PYGM(10), RAF1(8), RAPGEF1(10), RHEB(2), RHOQ(1), RPS6(1), RPS6KB1(2), RPS6KB2(3), SH2B2(5), SHC1(3), SHC2(7), SHC3(12), SHC4(2), SLC2A4(8), SOCS2(2), SOCS3(2), SOCS4(3), SORBS1(13), SOS1(9), SOS2(13), SREBF1(5), TRIP10(4), TSC1(5), TSC2(12) 61839857 1198 240 955 436 665 70 74 293 93 3 2.35e-09 1.000 1.000 83 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(12), ABL2(12), AKT1(3), AKT2(8), AKT3(4), ARAF(5), AREG(7), BRAF(147), BTC(4), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CBL(11), CBLB(19), CBLC(15), CDKN1A(4), CDKN1B(1), CRK(3), CRKL(2), EGF(19), EGFR(23), EIF4EBP1(1), ELK1(2), ERBB2(7), ERBB3(6), ERBB4(50), EREG(6), GAB1(4), GRB2(2), GSK3B(2), HBEGF(1), HRAS(4), JUN(1), KRAS(4), MAP2K1(13), MAP2K2(4), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(9), MAPK3(1), MAPK8(2), MAPK9(7), MYC(5), NCK1(1), NCK2(6), NRAS(73), NRG1(17), NRG2(7), NRG3(21), NRG4(1), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PAK7(48), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PLCG1(9), PLCG2(25), PRKCA(11), PRKCG(14), PTK2(8), RAF1(8), RPS6KB1(2), RPS6KB2(3), SHC1(3), SHC2(7), SHC3(12), SHC4(2), SOS1(9), SOS2(13), SRC(1), STAT5A(3), STAT5B(4), TGFA(3) 39707254 901 238 664 295 453 49 67 271 60 1 2.16e-07 1.000 1.000 84 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(7), ACTG1(5), CHAD(4), COL11A1(65), COL11A2(40), COL17A1(29), COL1A1(44), COL1A2(42), COL2A1(30), COL3A1(72), COL4A1(62), COL4A2(33), COL4A4(97), COL4A6(35), COL5A1(65), COL5A2(45), COL5A3(71), COL6A1(9), COL6A2(21), COL6A3(60), COL6A6(59), COMP(7), DES(8), DSC1(47), DSC2(36), DSC3(40), DSG1(61), DSG2(21), DSG3(65), DSG4(62), FN1(25), GJA1(8), GJA10(14), GJA3(1), GJA4(4), GJA5(7), GJA8(18), GJA9(3), GJB1(1), GJB2(3), GJB3(3), GJB4(7), GJB5(6), GJB6(6), GJB7(2), GJC1(7), GJC2(1), GJC3(2), GJD2(7), IBSP(8), INA(6), ITGA6(8), ITGB4(22), KRT1(19), KRT10(15), KRT12(12), KRT13(11), KRT14(2), KRT15(12), KRT16(12), KRT17(9), KRT18(4), KRT2(18), KRT20(7), KRT23(8), KRT24(8), KRT25(10), KRT27(5), KRT28(11), KRT3(16), KRT31(11), KRT32(11), KRT33A(5), KRT33B(3), KRT34(10), KRT35(9), KRT36(16), KRT37(11), KRT38(9), KRT39(13), KRT4(18), KRT40(6), KRT5(18), KRT6A(17), KRT6B(10), KRT6C(13), KRT7(6), KRT71(17), KRT72(12), KRT73(16), KRT74(14), KRT75(16), KRT76(12), KRT77(13), KRT78(20), KRT79(8), KRT8(7), KRT81(3), KRT82(9), KRT83(15), KRT84(10), KRT85(7), KRT86(7), KRT9(19), LAMA1(42), LAMA2(59), LAMA3(62), LAMA4(11), LAMA5(29), LAMB1(10), LAMB2(11), LAMB3(27), LAMB4(40), LAMC1(10), LAMC2(21), LAMC3(7), LMNA(9), LMNB1(2), LMNB2(4), NES(21), PRPH(1), RELN(76), SPP1(7), THBS1(30), THBS2(10), THBS3(11), THBS4(11), TNC(32), TNN(46), TNR(76), TNXB(143), VIM(5), VTN(7), VWF(51) 96655005 2852 231 2704 1218 2148 210 67 220 206 1 7.06e-11 1.000 1.000 85 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(29), ADCY2(8), ADCY3(4), ADCY4(6), ADCY7(10), ADCY8(51), ADCY9(9), ADORA2A(2), ADORA2B(3), ADRA1A(10), ADRA1B(4), ADRA1D(4), ADRB1(5), ADRB2(2), AGTR1(11), ATP2A1(9), ATP2A2(14), ATP2A3(16), ATP2B1(8), ATP2B2(30), ATP2B3(9), ATP2B4(16), AVPR1A(4), AVPR1B(9), BDKRB1(5), BDKRB2(10), BST1(1), CACNA1A(36), CACNA1B(28), CACNA1C(46), CACNA1D(34), CACNA1E(101), CACNA1F(21), CACNA1G(30), CACNA1H(26), CACNA1I(34), CACNA1S(48), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CAMK4(12), CCKAR(10), CCKBR(12), CD38(4), CHP(3), CHRM1(5), CHRM2(19), CHRM3(22), CHRM5(4), CHRNA7(3), CYSLTR1(5), CYSLTR2(4), DRD1(11), EDNRA(9), EDNRB(5), EGFR(23), ERBB2(7), ERBB3(6), ERBB4(50), F2R(7), GNA11(7), GNA14(5), GNA15(5), GNAL(2), GNAQ(5), GNAS(22), GRIN1(7), GRIN2A(91), GRIN2C(8), GRIN2D(6), GRM1(17), GRM5(15), GRPR(5), HRH1(18), HRH2(4), HTR2A(9), HTR2B(2), HTR2C(12), HTR4(10), HTR5A(17), HTR6(1), HTR7(8), ITPKA(1), ITPKB(6), ITPR1(36), ITPR2(18), ITPR3(9), LHCGR(27), LTB4R2(1), MYLK(41), MYLK2(13), NOS1(65), NOS3(17), NTSR1(6), OXTR(5), P2RX1(4), P2RX2(3), P2RX3(10), P2RX4(2), P2RX5(8), P2RX7(5), PDE1A(37), PDE1B(13), PDE1C(44), PDGFRA(32), PDGFRB(18), PHKA1(23), PHKA2(7), PHKB(7), PHKG1(1), PHKG2(2), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), PLCD1(4), PLCD3(3), PLCD4(4), PLCE1(53), PLCG1(9), PLCG2(25), PLCZ1(26), PPID(1), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(8), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(11), PRKCG(14), PRKX(4), PTAFR(2), PTGER3(3), PTGFR(22), PTK2B(11), RYR1(93), RYR2(90), RYR3(81), SLC25A6(2), SLC8A1(32), SLC8A2(11), SLC8A3(39), SPHK1(1), SPHK2(7), TACR1(8), TACR2(8), TACR3(28), TBXA2R(4), TNNC1(2), TNNC2(3), TRHR(21), TRPC1(6), VDAC1(1), VDAC2(1), VDAC3(1) 103030060 2489 231 2340 1601 1778 183 86 221 216 5 0.00629 1.000 1.000 86 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(4), ACVR1B(3), ACVR2A(3), ACVR2B(3), AMHR2(16), BMP2(6), BMP7(2), BMPR1A(2), BMPR1B(4), BMPR2(6), CCL1(1), CCL11(1), CCL13(1), CCL14(2), CCL15(3), CCL16(1), CCL18(1), CCL2(1), CCL20(2), CCL21(2), CCL22(1), CCL23(1), CCL24(3), CCL25(1), CCL26(1), CCL27(2), CCL28(1), CCL7(4), CCL8(3), CCR1(10), CCR2(17), CCR3(11), CCR4(8), CCR5(7), CCR6(3), CCR7(3), CCR8(6), CCR9(5), CD27(3), CD40(4), CD40LG(2), CLCF1(1), CNTF(1), CNTFR(3), CSF1(11), CSF1R(13), CSF2(2), CSF2RA(20), CSF2RB(18), CSF3(5), CSF3R(8), CX3CL1(4), CX3CR1(13), CXCL10(3), CXCL11(1), CXCL12(2), CXCL13(1), CXCL14(1), CXCL3(1), CXCL5(2), CXCL6(1), CXCL9(3), CXCR3(5), CXCR4(4), CXCR6(4), EDA(2), EDA2R(4), EDAR(5), EGF(19), EGFR(23), EPO(6), EPOR(1), FAS(5), FASLG(14), FLT1(33), FLT3(31), FLT3LG(2), FLT4(27), GDF5(14), GH1(3), GH2(10), GHR(30), HGF(24), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(10), IFNA17(2), IFNA2(1), IFNA21(9), IFNA4(1), IFNA5(3), IFNA6(3), IFNA7(5), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IFNG(2), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(4), IL10(3), IL10RA(8), IL10RB(5), IL11(2), IL11RA(3), IL12A(3), IL12B(4), IL12RB1(17), IL12RB2(3), IL13(2), IL13RA1(3), IL15(3), IL15RA(7), IL17A(10), IL17B(3), IL17RA(6), IL17RB(2), IL18(2), IL18R1(17), IL18RAP(19), IL19(3), IL1A(4), IL1B(7), IL1R1(12), IL1R2(9), IL1RAP(4), IL2(4), IL20(4), IL20RA(10), IL21(6), IL21R(18), IL22(2), IL22RA1(12), IL22RA2(1), IL23A(2), IL23R(7), IL25(2), IL26(3), IL28A(2), IL28B(4), IL28RA(4), IL29(2), IL2RA(4), IL2RB(7), IL2RG(3), IL3(3), IL3RA(8), IL4(1), IL4R(14), IL5(4), IL5RA(14), IL6(2), IL6R(4), IL6ST(10), IL7(5), IL7R(33), IL8(1), IL9(1), IL9R(6), INHBA(19), INHBB(8), INHBC(11), INHBE(3), KDR(45), KIT(10), KITLG(9), LEP(2), LEPR(25), LIF(2), LIFR(33), LTA(2), LTB(2), MET(23), MPL(8), NGFR(8), OSM(8), OSMR(40), PDGFB(4), PDGFC(18), PDGFRA(32), PDGFRB(18), PLEKHO2(5), PPBP(5), PRL(1), PRLR(30), RELT(2), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(7), TNF(1), TNFRSF10A(5), TNFRSF10B(3), TNFRSF10C(4), TNFRSF10D(8), TNFRSF11A(5), TNFRSF11B(10), TNFRSF12A(1), TNFRSF13B(8), TNFRSF14(2), TNFRSF17(6), TNFRSF18(4), TNFRSF19(2), TNFRSF1A(3), TNFRSF1B(3), TNFRSF21(10), TNFRSF25(5), TNFRSF4(4), TNFRSF6B(2), TNFRSF8(20), TNFRSF9(4), TNFSF10(8), TNFSF11(4), TNFSF12(1), TNFSF13B(1), TNFSF14(11), TNFSF15(7), TNFSF18(7), TNFSF4(3), TNFSF8(4), TNFSF9(1), TPO(45), TSLP(1), VEGFA(7), VEGFB(1), VEGFC(19), XCL1(1), XCL2(2), XCR1(4) 68381179 1603 229 1536 869 1144 111 45 143 160 0 0.0164 1.000 1.000 87 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(12), ACTN1(5), ACTR2(3), ACTR3(2), AKT1(3), AKT2(8), AKT3(4), ANGPTL2(3), ARHGEF6(10), ARHGEF7(4), BCAR1(5), BRAF(147), CAV1(2), CDC42(3), CDKN2A(34), CRK(3), CSE1L(5), DOCK1(15), EPHB2(31), FYN(7), GRB2(2), GRB7(6), GRLF1(12), ITGA1(18), ITGA10(10), ITGA11(17), ITGA2(14), ITGA3(7), ITGA4(38), ITGA5(25), ITGA6(8), ITGA7(25), ITGA8(36), ITGA9(14), ITGB3BP(2), MAP2K4(4), MAP2K7(4), MAP3K11(6), MAPK1(4), MAPK10(9), MAPK8(2), MAPK8IP1(5), MAPK8IP2(9), MAPK8IP3(9), MAPK9(7), MRAS(2), MYLK(41), MYLK2(13), P4HB(3), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PAK7(48), PIK3CA(9), PIK3CB(26), PKLR(11), PLCG1(9), PLCG2(25), PTEN(23), PTK2(8), RAF1(8), RALA(1), RHO(2), ROCK1(5), ROCK2(13), SHC1(3), SOS1(9), SOS2(13), SRC(1), TERF2IP(2), TLN1(14), TLN2(25), VASP(3), WAS(7), ZYX(7) 47101145 961 229 774 354 517 53 40 245 106 0 1.28e-06 1.000 1.000 88 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(13), CD36(4), CD44(6), CD47(1), CHAD(4), COL11A1(65), COL11A2(40), COL1A1(44), COL1A2(42), COL2A1(30), COL3A1(72), COL4A1(62), COL4A2(33), COL4A4(97), COL4A6(35), COL5A1(65), COL5A2(45), COL5A3(71), COL6A1(9), COL6A2(21), COL6A3(60), COL6A6(59), DAG1(6), FN1(25), FNDC1(40), FNDC3A(11), FNDC4(5), FNDC5(3), GP5(4), GP6(5), GP9(6), HMMR(4), HSPG2(26), IBSP(8), ITGA1(18), ITGA10(10), ITGA11(17), ITGA2(14), ITGA2B(11), ITGA3(7), ITGA4(38), ITGA5(25), ITGA6(8), ITGA7(25), ITGA8(36), ITGA9(14), ITGAV(9), ITGB1(4), ITGB3(12), ITGB4(22), ITGB5(7), ITGB6(12), ITGB7(6), ITGB8(17), LAMA1(42), LAMA2(59), LAMA3(62), LAMA4(11), LAMA5(29), LAMB1(10), LAMB2(11), LAMB3(27), LAMB4(40), LAMC1(10), LAMC2(21), LAMC3(7), RELN(76), SDC1(4), SDC2(2), SDC3(6), SDC4(3), SPP1(7), SV2A(16), SV2B(30), SV2C(14), THBS1(30), THBS2(10), THBS3(11), THBS4(11), TNC(32), TNN(46), TNR(76), TNXB(143), VTN(7), VWF(51) 86770935 2237 226 2143 939 1676 132 65 188 175 1 8.19e-05 1.000 1.000 89 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(12), ABLIM1(13), ABLIM2(6), ABLIM3(9), ARHGEF12(12), CDC42(3), CDK5(4), CFL1(1), CHP(3), CXCL12(2), CXCR4(4), DCC(81), DPYSL2(4), DPYSL5(13), EFNA2(1), EFNA4(2), EFNA5(3), EFNB1(1), EFNB3(5), EPHA1(17), EPHA2(14), EPHA3(26), EPHA4(19), EPHA5(7), EPHA6(69), EPHA7(44), EPHA8(16), EPHB1(27), EPHB2(31), EPHB3(15), EPHB4(11), EPHB6(27), FES(7), FYN(7), GNAI1(1), GNAI2(5), GNAI3(3), GSK3B(2), HRAS(4), ITGB1(4), KRAS(4), L1CAM(9), LIMK1(4), LIMK2(9), LRRC4C(39), MAPK1(4), MAPK3(1), MET(23), NCK1(1), NCK2(6), NFAT5(8), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NGEF(14), NRAS(73), NRP1(23), NTN4(17), NTNG1(15), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PAK7(48), PLXNA1(14), PLXNA2(13), PLXNA3(10), PLXNB1(22), PLXNB2(16), PLXNB3(7), PLXNC1(18), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(8), PTK2(8), RAC1(17), RAC2(1), RASA1(4), RGS3(13), RHOA(1), RHOD(2), RND1(5), ROBO1(23), ROBO2(38), ROBO3(14), ROCK1(5), ROCK2(13), SEMA3A(13), SEMA3B(2), SEMA3C(3), SEMA3D(13), SEMA3E(25), SEMA3F(10), SEMA3G(14), SEMA4A(10), SEMA4B(4), SEMA4C(7), SEMA4D(10), SEMA4F(6), SEMA4G(9), SEMA5A(19), SEMA5B(17), SEMA6A(8), SEMA6B(7), SEMA6C(9), SEMA6D(5), SEMA7A(3), SLIT1(18), SLIT2(61), SLIT3(53), SRGAP1(6), SRGAP2(7), SRGAP3(34), UNC5A(9), UNC5B(12), UNC5C(19), UNC5D(27) 75447909 1614 224 1460 800 1077 121 74 210 130 2 0.000793 1.000 1.000 90 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(7), ACTG1(5), ACTN1(5), ACTN2(24), ACTN3(7), ACTN4(5), AKT1(3), AKT2(8), AKT3(4), AMOTL1(2), ASH1L(28), CASK(5), CDC42(3), CDK4(5), CGN(9), CLDN1(5), CLDN10(5), CLDN11(5), CLDN14(5), CLDN16(7), CLDN17(6), CLDN18(7), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(1), CLDN4(10), CLDN6(9), CLDN7(1), CLDN8(3), CLDN9(1), CRB3(1), CSDA(3), CSNK2A1(1), CSNK2A2(1), CSNK2B(2), CTNNA1(2), CTNNA2(27), CTNNA3(30), CTNNB1(13), CTTN(3), EPB41(8), EPB41L1(11), EPB41L2(20), EPB41L3(6), EXOC3(3), EXOC4(9), F11R(5), GNAI1(1), GNAI2(5), GNAI3(3), HCLS1(14), HRAS(4), IGSF5(11), INADL(42), JAM2(10), JAM3(2), KRAS(4), LLGL1(4), LLGL2(14), MAGI1(28), MAGI2(29), MAGI3(12), MLLT4(13), MPDZ(13), MPP5(1), MRAS(2), MYH1(96), MYH10(13), MYH11(28), MYH13(39), MYH14(17), MYH15(56), MYH2(86), MYH3(21), MYH4(86), MYH6(32), MYH7(47), MYH7B(25), MYH8(58), MYH9(12), MYL2(5), MYL5(1), MYL7(2), MYL9(2), MYLPF(2), NRAS(73), OCLN(4), PARD3(17), PARD6A(2), PARD6B(2), PARD6G(3), PPM1J(1), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(4), PPP2R2A(2), PPP2R2B(6), PPP2R2C(6), PPP2R3A(7), PPP2R3B(4), PPP2R4(2), PRKCA(11), PRKCD(4), PRKCE(6), PRKCG(14), PRKCH(11), PRKCI(8), PRKCQ(18), PRKCZ(6), PTEN(23), RAB3B(1), RHOA(1), RRAS(1), SPTAN1(8), SRC(1), SYMPK(6), TJAP1(3), TJP1(11), TJP2(9), TJP3(21), VAPA(1), YES1(5), ZAK(7) 74802542 1495 224 1354 890 975 132 75 184 126 3 0.337 1.000 1.000 91 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(147), CPEB1(8), EGFR(23), ERBB2(7), ERBB4(50), ETS1(5), ETS2(9), ETV6(13), ETV7(3), FMN2(74), GRB2(2), KRAS(4), MAP2K1(13), MAPK1(4), MAPK3(1), NOTCH1(5), NOTCH2(41), NOTCH3(23), NOTCH4(57), PIWIL1(21), PIWIL2(13), PIWIL3(13), PIWIL4(6), RAF1(8), SOS1(9), SOS2(13), SPIRE1(2), SPIRE2(6) 20321583 580 221 426 181 305 25 20 196 34 0 0.000121 1.000 1.000 92 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(5), ACTA2(4), ACTN2(24), ACTN3(7), ACTN4(5), DES(8), DMD(34), FAM48A(1), MYBPC1(20), MYBPC2(19), MYBPC3(18), MYH3(21), MYH6(32), MYH7(47), MYH8(58), MYL1(12), MYL2(5), MYL3(2), MYL4(5), MYL9(2), MYOM1(24), NEB(119), TCAP(1), TNNC2(3), TNNI1(2), TNNI2(3), TNNI3(2), TNNT1(3), TNNT2(4), TNNT3(3), TPM1(3), TPM2(3), TPM3(2), TPM4(2), TTN(1177), VIM(5) 51509623 1685 221 1558 718 1253 115 56 157 93 11 7.31e-08 1.000 1.000 93 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(29), ADCY2(8), ADCY3(4), ADCY4(6), ADCY5(17), ADCY6(7), ADCY7(10), ADCY8(51), ADCY9(9), ADRA1A(10), ADRA1B(4), ADRA1D(4), ADRB1(5), ADRB2(2), ANXA6(6), ARRB1(3), ARRB2(6), ATP1A4(12), ATP1B1(1), ATP1B2(2), ATP1B3(1), ATP2A2(14), ATP2A3(16), ATP2B1(8), ATP2B2(30), ATP2B3(9), CACNA1A(36), CACNA1B(28), CACNA1C(46), CACNA1D(34), CACNA1E(101), CACNA1S(48), CACNB1(4), CACNB3(2), CALM1(1), CALM2(1), CALR(1), CAMK1(5), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CAMK4(12), CASQ1(9), CASQ2(5), CHRM1(5), CHRM2(19), CHRM3(22), CHRM4(6), CHRM5(4), GJA1(8), GJA4(4), GJA5(7), GJB1(1), GJB2(3), GJB3(3), GJB4(7), GJB5(6), GJB6(6), GNA11(7), GNAI2(5), GNAI3(3), GNAO1(2), GNAQ(5), GNAZ(6), GNB3(7), GNB4(3), GNB5(3), GNG2(3), GNG4(2), GNG7(2), GRK4(8), GRK5(4), GRK6(3), ITPR1(36), ITPR2(18), ITPR3(9), KCNB1(37), KCNJ3(22), KCNJ5(15), MIB1(6), NME7(4), PKIA(4), PKIB(1), PKIG(1), PLCB3(6), PRKACA(4), PRKACB(4), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(11), PRKCD(4), PRKCE(6), PRKCG(14), PRKCH(11), PRKCQ(18), PRKCZ(6), PRKD1(3), RGS1(3), RGS11(2), RGS14(3), RGS16(2), RGS18(10), RGS20(2), RGS3(13), RGS4(3), RGS5(2), RGS6(16), RGS7(40), RGS9(11), RYR1(93), RYR2(90), RYR3(81), SFN(1), SLC8A1(32), SLC8A3(39), USP5(4), YWHAB(1), YWHAQ(3) 71995250 1495 220 1407 1039 1037 140 60 131 124 3 0.656 1.000 1.000 94 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(29), ADCY2(8), ADCY3(4), ADCY4(6), ADCY5(17), ADCY6(7), ADCY7(10), ADCY8(51), ADCY9(9), ADRB1(5), CSNK1D(1), DRD1(11), DRD2(17), EGF(19), EGFR(23), GJA1(8), GJD2(7), GNA11(7), GNAI1(1), GNAI2(5), GNAI3(3), GNAQ(5), GNAS(22), GRB2(2), GRM1(17), GRM5(15), GUCY1A2(21), GUCY1A3(34), GUCY1B3(7), GUCY2C(32), GUCY2D(10), GUCY2F(16), HRAS(4), HTR2A(9), HTR2B(2), HTR2C(12), ITPR1(36), ITPR2(18), ITPR3(9), KRAS(4), MAP2K1(13), MAP2K2(4), MAP2K5(3), MAP3K2(6), MAPK1(4), MAPK3(1), MAPK7(4), NPR1(18), NPR2(14), NRAS(73), PDGFA(1), PDGFB(4), PDGFC(18), PDGFD(7), PDGFRA(32), PDGFRB(18), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(11), PRKCG(14), PRKG1(13), PRKG2(16), PRKX(4), RAF1(8), SOS1(9), SOS2(13), SRC(1), TJP1(11), TUBA1A(2), TUBA1B(4), TUBA1C(2), TUBA3C(22), TUBA3D(12), TUBA3E(4), TUBA4A(6), TUBA8(3), TUBAL3(13), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(5), TUBB4(4), TUBB4Q(10), TUBB6(10), TUBB8(15) 50875953 1119 216 985 572 722 86 75 154 81 1 0.000350 1.000 1.000 95 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(5), BRAF(147), CHUK(2), DAXX(10), ELK1(2), FOS(2), GRB2(2), HRAS(4), IKBKB(4), JUN(1), MAP2K1(13), MAP2K2(4), MAP2K3(9), MAP2K4(4), MAP2K5(3), MAP2K6(3), MAP2K7(4), MAP3K1(3), MAP3K10(8), MAP3K11(6), MAP3K12(4), MAP3K13(10), MAP3K14(4), MAP3K2(6), MAP3K3(6), MAP3K4(16), MAP3K5(18), MAP3K6(6), MAP3K7(1), MAP3K9(24), MAP4K1(9), MAP4K2(6), MAP4K3(8), MAP4K4(8), MAP4K5(3), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(2), MAPK13(5), MAPK14(5), MAPK3(1), MAPK4(18), MAPK6(6), MAPK7(4), MAPK8(2), MAPK9(7), MAPKAPK2(5), MAPKAPK3(4), MAPKAPK5(1), MEF2A(5), MEF2B(3), MEF2C(3), MEF2D(5), MKNK1(5), MKNK2(2), MYC(5), NFKB1(7), NFKBIA(2), PAK1(4), PAK2(8), RAC1(17), RAF1(8), RELA(5), RIPK1(1), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), RPS6KA4(4), RPS6KA5(4), RPS6KB1(2), RPS6KB2(3), SHC1(3), SP1(5), STAT1(4), TGFB1(1), TGFB2(1), TGFB3(3), TRAF2(3) 36577293 571 215 418 203 275 46 25 187 38 0 0.00258 1.000 1.000 96 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(5), ACTA2(4), ADCY1(29), ADCY2(8), ADCY3(4), ADCY4(6), ADCY5(17), ADCY6(7), ADCY7(10), ADCY8(51), ADCY9(9), ARRB1(3), ARRB2(6), ATF1(5), ATF2(5), ATF4(7), ATF5(7), ATP2A2(14), ATP2A3(16), CACNB3(2), CALCA(2), CALM1(1), CALM2(1), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CNN1(6), CNN2(2), CORIN(31), CREB3(1), CRH(3), CRHR1(7), DGKZ(8), ETS2(9), FOS(2), GABPA(1), GABPB2(9), GBA2(2), GJA1(8), GNAQ(5), GNB3(7), GNB4(3), GNB5(3), GNG2(3), GNG4(2), GNG7(2), GRK4(8), GRK5(4), GRK6(3), GSTO1(2), GUCA2A(1), GUCA2B(1), GUCY1A3(34), IGFBP1(3), IGFBP2(2), IGFBP3(2), IGFBP6(2), IL1B(7), IL6(2), ITPR1(36), ITPR2(18), ITPR3(9), JUN(1), MIB1(6), MYL2(5), MYL4(5), MYLK2(13), NFKB1(7), NOS1(65), NOS3(17), OXTR(5), PDE4B(7), PDE4D(8), PKIA(4), PKIB(1), PKIG(1), PLCB3(6), PLCD1(4), PLCG1(9), PLCG2(25), PRKACA(4), PRKACB(4), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(11), PRKCD(4), PRKCE(6), PRKCH(11), PRKCQ(18), PRKCZ(6), PRKD1(3), RAMP1(1), RAMP2(1), RAMP3(2), RGS1(3), RGS11(2), RGS14(3), RGS16(2), RGS18(10), RGS20(2), RGS3(13), RGS4(3), RGS5(2), RGS6(16), RGS7(40), RGS9(11), RLN1(3), RYR1(93), RYR2(90), RYR3(81), SFN(1), SLC8A1(32), SP1(5), TNXB(143), USP5(4), YWHAB(1), YWHAQ(3) 67241494 1323 215 1250 774 936 113 48 124 99 3 0.0212 1.000 1.000 97 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(3), AKT2(8), AKT3(4), CBL(11), CBLB(19), CBLC(15), CCND1(1), CCND2(5), CCND3(2), CISH(3), CLCF1(1), CNTF(1), CNTFR(3), CREBBP(23), CSF2(2), CSF2RA(20), CSF2RB(18), CSF3(5), CSF3R(8), EP300(14), EPO(6), EPOR(1), GH1(3), GH2(10), GHR(30), GRB2(2), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(10), IFNA17(2), IFNA2(1), IFNA21(9), IFNA4(1), IFNA5(3), IFNA6(3), IFNA7(5), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IFNG(2), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(4), IL10(3), IL10RA(8), IL10RB(5), IL11(2), IL11RA(3), IL12A(3), IL12B(4), IL12RB1(17), IL12RB2(3), IL13(2), IL13RA1(3), IL13RA2(3), IL15(3), IL15RA(7), IL19(3), IL2(4), IL20(4), IL20RA(10), IL21(6), IL21R(18), IL22(2), IL22RA1(12), IL22RA2(1), IL23A(2), IL23R(7), IL26(3), IL28A(2), IL28B(4), IL28RA(4), IL29(2), IL2RA(4), IL2RB(7), IL2RG(3), IL3(3), IL3RA(8), IL4(1), IL4R(14), IL5(4), IL5RA(14), IL6(2), IL6R(4), IL6ST(10), IL7(5), IL7R(33), IL9(1), IL9R(6), IRF9(2), JAK1(6), JAK2(9), JAK3(7), LEP(2), LEPR(25), LIF(2), LIFR(33), MPL(8), MYC(5), OSM(8), OSMR(40), PIAS1(5), PIAS2(6), PIAS3(5), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PIM1(2), PRL(1), PRLR(30), PTPN11(10), PTPN6(3), SOCS2(2), SOCS3(2), SOCS4(3), SOCS5(5), SOCS7(4), SOS1(9), SOS2(13), SPRED1(5), SPRED2(2), SPRY1(7), SPRY2(4), SPRY3(12), SPRY4(2), STAM(4), STAM2(1), STAT1(4), STAT2(8), STAT3(11), STAT4(22), STAT5A(3), STAT5B(4), STAT6(8), TPO(45), TSLP(1), TYK2(8) 56307861 1057 214 1013 486 695 80 38 134 109 1 0.00774 1.000 1.000 98 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(3), AKT2(8), AKT3(4), BRAF(147), DAG1(6), DRD2(17), EGFR(23), EPHB2(31), GRB2(2), ITPKA(1), ITPKB(6), ITPR1(36), ITPR2(18), ITPR3(9), KCNJ3(22), KCNJ5(15), KCNJ9(4), MAPK1(4), PI3(6), PIK3CB(26), PITX2(4), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), RAF1(8), RGS20(2), SHC1(3), SOS1(9), SOS2(13), SRC(1), STAT3(11), TERF2IP(2) 22648202 582 212 420 219 290 37 33 185 36 1 0.000201 1.000 1.000 99 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(22), APC2(9), AXIN1(11), AXIN2(4), BTRC(5), CACYBP(2), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CCND1(1), CCND2(5), CCND3(2), CER1(13), CHD8(23), CHP(3), CREBBP(23), CSNK1A1(3), CSNK1A1L(6), CSNK1E(4), CSNK2A1(1), CSNK2A2(1), CSNK2B(2), CTBP2(1), CTNNB1(13), CTNNBIP1(1), CUL1(7), CXXC4(1), DAAM1(5), DAAM2(6), DKK1(2), DKK2(17), DKK4(3), DVL2(3), DVL3(7), EP300(14), FBXW11(5), FZD1(4), FZD10(2), FZD2(5), FZD4(2), FZD5(2), FZD6(2), FZD7(4), FZD8(6), FZD9(1), GSK3B(2), JUN(1), LEF1(3), LRP5(19), LRP6(26), MAP3K7(1), MAPK10(9), MAPK8(2), MAPK9(7), MMP7(6), MYC(5), NFAT5(8), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NKD1(8), NKD2(6), NLK(6), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), PORCN(5), PPARD(3), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(4), PPP2R2A(2), PPP2R2B(6), PPP2R2C(6), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(8), PRICKLE1(10), PRICKLE2(6), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(11), PRKCG(14), PRKX(4), PSEN1(1), RAC1(17), RAC2(1), RHOA(1), ROCK1(5), ROCK2(13), RUVBL1(1), SENP2(12), SFRP1(2), SFRP2(10), SFRP4(6), SMAD2(3), SMAD3(2), SMAD4(2), SOX17(6), TBL1X(5), TBL1XR1(1), TBL1Y(7), TCF7(2), TCF7L1(3), TCF7L2(7), TP53(43), VANGL1(2), VANGL2(9), WIF1(8), WNT1(2), WNT10A(7), WNT10B(5), WNT11(4), WNT16(1), WNT2(7), WNT2B(5), WNT3(6), WNT3A(6), WNT4(2), WNT5A(5), WNT5B(5), WNT6(2), WNT7A(14), WNT7B(6), WNT8A(7), WNT8B(7), WNT9A(3), WNT9B(3) 62137458 949 211 899 445 592 75 46 134 101 1 0.0188 1.000 1.000 100 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(6), ADORA2A(2), ADORA2B(3), ADORA3(12), ADRA1A(10), ADRA1B(4), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(2), AGTR1(11), AGTR2(12), AVPR1A(4), AVPR1B(9), AVPR2(1), BDKRB1(5), BDKRB2(10), BRS3(5), C3AR1(5), CCBP2(8), CCKAR(10), CCKBR(12), CCR1(10), CCR10(2), CCR2(17), CCR3(11), CCR4(8), CCR5(7), CCR6(3), CCR7(3), CCR8(6), CCR9(5), CCRL1(1), CCRL2(5), CHML(4), CHRM1(5), CHRM2(19), CHRM3(22), CHRM4(6), CHRM5(4), CMKLR1(13), CNR1(9), CNR2(4), CX3CR1(13), CXCR3(5), CXCR4(4), DRD1(11), DRD2(17), DRD3(6), DRD4(1), DRD5(23), EDNRA(9), EDNRB(5), F2R(7), F2RL1(16), F2RL2(6), F2RL3(3), FPR1(20), FSHR(19), GALR1(5), GALR2(1), GALR3(2), GALT(2), GHSR(11), GNB2L1(3), GPR17(1), GPR173(1), GPR174(12), GPR27(2), GPR3(2), GPR35(3), GPR37(9), GPR37L1(6), GPR4(4), GPR50(20), GPR6(6), GPR63(6), GPR77(5), GPR83(14), GPR85(5), GPR87(5), GRPR(5), HCRTR1(3), HCRTR2(29), HRH1(18), HRH2(4), HRH3(4), HTR1A(8), HTR1B(1), HTR1D(3), HTR1E(6), HTR1F(8), HTR2A(9), HTR2B(2), HTR2C(12), HTR4(10), HTR5A(17), HTR6(1), HTR7(8), LHCGR(27), LTB4R(1), MAS1(4), MC3R(7), MC4R(1), MC5R(7), MLNR(1), MTNR1A(8), MTNR1B(7), NMBR(8), NMUR1(6), NMUR2(15), NPY1R(25), NPY2R(14), NPY5R(24), NTSR1(6), NTSR2(3), OPN1SW(2), OPN3(3), OPRD1(2), OPRK1(23), OPRL1(5), OPRM1(5), OR10A5(7), OR11A1(7), OR12D3(5), OR1C1(11), OR1F1(7), OR1Q1(8), OR2H1(7), OR5V1(10), OR7A5(3), OR7C1(2), OR8B8(10), OXTR(5), P2RY1(4), P2RY10(7), P2RY12(3), P2RY13(4), P2RY14(9), P2RY2(8), P2RY6(1), PPYR1(12), PTAFR(2), PTGDR(9), PTGER2(6), PTGER4(1), PTGFR(22), PTGIR(6), RGR(6), RHO(2), RRH(1), SSTR1(11), SSTR2(6), SSTR3(12), SSTR4(4), SUCNR1(10), TBXA2R(4), TRHR(21) 46836893 1204 208 1133 909 810 129 39 137 89 0 0.00393 1.000 1.000 101 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(25), BDKRB1(5), BDKRB2(10), C1QA(5), C1QB(5), C1QC(8), C1R(14), C1S(20), C2(16), C3(49), C3AR1(5), C4BPA(18), C4BPB(6), C5(16), C5AR1(9), C6(66), C7(52), C8A(40), C8B(48), C8G(1), C9(22), CD55(4), CD59(1), CFB(33), CFH(49), CFI(16), CPB2(1), CR1(54), CR2(33), F10(10), F11(15), F12(1), F13A1(28), F13B(24), F2(9), F2R(7), F3(2), F5(37), F7(9), F8(46), F9(12), FGA(42), FGB(10), FGG(8), KLKB1(25), KNG1(14), MASP1(9), MASP2(9), MBL2(13), PLAT(4), PLAU(3), PLAUR(2), PLG(33), PROC(9), PROS1(13), SERPINA1(7), SERPINA5(11), SERPINC1(8), SERPIND1(4), SERPINE1(5), SERPINF2(8), SERPING1(12), TFPI(10), THBD(3), VWF(51) 34918588 1144 208 1059 474 813 84 44 111 90 2 1.11e-05 1.000 1.000 102 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(6), CADM1(3), CADM3(19), CD2(23), CD22(26), CD226(6), CD274(1), CD276(6), CD28(1), CD34(4), CD4(6), CD40(4), CD40LG(2), CD58(1), CD6(10), CD80(5), CD86(21), CD8A(2), CD8B(8), CD99(2), CDH1(7), CDH15(10), CDH2(13), CDH4(29), CDH5(12), CLDN1(5), CLDN10(5), CLDN11(5), CLDN14(5), CLDN16(7), CLDN17(6), CLDN18(7), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(1), CLDN4(10), CLDN6(9), CLDN7(1), CLDN8(3), CLDN9(1), CNTN1(22), CNTN2(15), CNTNAP1(11), CNTNAP2(81), CTLA4(2), ESAM(3), F11R(5), GLG1(6), HLA-A(3), HLA-B(5), HLA-C(1), HLA-DMA(4), HLA-DMB(7), HLA-DOA(5), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(7), HLA-DQB1(5), HLA-DRA(11), HLA-DRB1(4), HLA-DRB5(1), HLA-E(1), HLA-F(6), HLA-G(4), ICAM1(3), ICAM2(4), ICAM3(2), ICOS(3), ICOSLG(2), ITGA4(38), ITGA6(8), ITGA8(36), ITGA9(14), ITGAL(24), ITGAM(21), ITGAV(9), ITGB1(4), ITGB2(14), ITGB7(6), ITGB8(17), JAM2(10), JAM3(2), L1CAM(9), MADCAM1(1), MAG(12), MPZ(5), MPZL1(1), NCAM1(11), NCAM2(10), NEGR1(6), NEO1(15), NFASC(39), NLGN1(10), NLGN2(6), NLGN3(6), NRCAM(9), NRXN1(47), NRXN2(17), NRXN3(30), OCLN(4), PDCD1(3), PDCD1LG2(3), PTPRC(33), PTPRF(28), PTPRM(8), PVR(3), PVRL1(4), PVRL2(6), PVRL3(5), SDC1(4), SDC2(2), SDC3(6), SDC4(3), SELE(36), SELL(8), SELP(31), SELPLG(8), SIGLEC1(26), SPN(6), VCAM1(18), VCAN(41) 56622608 1260 206 1198 587 883 96 46 135 100 0 6.41e-06 1.000 1.000 103 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(29), ADCY2(8), ADCY3(4), ADCY4(6), ADCY5(17), ADCY6(7), ADCY7(10), ADCY8(51), ADCY9(9), ATF4(7), CACNA1C(46), CACNA1D(34), CACNA1F(21), CACNA1S(48), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CDC42(3), CGA(1), EGFR(23), ELK1(2), FSHB(4), GNA11(7), GNAQ(5), GNAS(22), GNRH2(2), GNRHR(2), GRB2(2), HBEGF(1), HRAS(4), ITPR1(36), ITPR2(18), ITPR3(9), JUN(1), KRAS(4), MAP2K1(13), MAP2K2(4), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(4), MAP3K1(3), MAP3K2(6), MAP3K3(6), MAP3K4(16), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(2), MAPK13(5), MAPK14(5), MAPK3(1), MAPK7(4), MAPK8(2), MAPK9(7), MMP14(2), MMP2(7), NRAS(73), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(7), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), PLD1(12), PLD2(7), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(11), PRKCD(4), PRKX(4), PTK2B(11), RAF1(8), SOS1(9), SOS2(13), SRC(1) 48763050 964 206 844 552 598 80 71 140 74 1 0.171 1.000 1.000 104 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(29), ADCY2(8), ADCY3(4), ADCY4(6), ADCY5(17), ADCY6(7), ADCY7(10), ADCY8(51), ADCY9(9), AKAP1(10), AKAP10(3), AKAP11(17), AKAP12(4), AKAP3(21), AKAP4(16), AKAP6(39), AKAP7(3), AKAP8(6), AKAP9(31), ARHGEF1(1), CALM1(1), CALM2(1), CHMP1B(1), GNA11(7), GNA12(3), GNA13(1), GNA14(5), GNA15(5), GNAI2(5), GNAI3(3), GNAL(2), GNAO1(2), GNAQ(5), GNAZ(6), GNB3(7), GNB5(3), GNG4(2), GNG7(2), GNGT2(4), HRAS(4), ITPR1(36), KCNJ3(22), KRAS(4), NRAS(73), PDE1A(37), PDE1B(13), PDE1C(44), PDE4A(9), PDE4B(7), PDE4C(18), PDE4D(8), PDE7A(2), PDE7B(17), PDE8A(3), PDE8B(21), PLCB3(6), PPP3CA(5), PPP3CC(2), PRKACA(4), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(11), PRKCD(4), PRKCE(6), PRKCG(14), PRKCH(11), PRKCI(8), PRKCQ(18), PRKCZ(6), PRKD1(3), PRKD3(4), RHOA(1), RRAS(1), SLC9A1(4), USP5(4) 45219945 810 205 712 422 510 60 61 126 53 0 0.0802 1.000 1.000 105 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(29), ADCY2(8), ADCY3(4), ADCY4(6), ADCY5(17), ADCY6(7), ADCY7(10), ADCY8(51), ADCY9(9), ASIP(2), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CREB3(1), CREB3L1(6), CREB3L2(7), CREB3L3(10), CREB3L4(5), CREBBP(23), CTNNB1(13), DCT(3), DVL2(3), DVL3(7), EDN1(9), EDNRB(5), EP300(14), FZD1(4), FZD10(2), FZD2(5), FZD4(2), FZD5(2), FZD6(2), FZD7(4), FZD8(6), FZD9(1), GNAI1(1), GNAI2(5), GNAI3(3), GNAO1(2), GNAQ(5), GNAS(22), GSK3B(2), HRAS(4), KIT(10), KITLG(9), KRAS(4), LEF1(3), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK3(1), MITF(4), NRAS(73), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), POMC(3), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(11), PRKCG(14), PRKX(4), RAF1(8), TCF7(2), TCF7L1(3), TCF7L2(7), TYR(8), TYRP1(8), WNT1(2), WNT10A(7), WNT10B(5), WNT11(4), WNT16(1), WNT2(7), WNT2B(5), WNT3(6), WNT3A(6), WNT4(2), WNT5A(5), WNT5B(5), WNT6(2), WNT7A(14), WNT7B(6), WNT8A(7), WNT8B(7), WNT9A(3), WNT9B(3) 41763117 798 205 688 417 481 64 64 122 66 1 0.0294 1.000 1.000 106 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(3), AKT2(8), AKT3(4), BRAF(147), CAB39(1), DDIT4(1), EIF4B(4), EIF4EBP1(1), FIGF(4), HIF1A(5), IGF1(11), MAPK1(4), MAPK3(1), PDPK1(4), PGF(1), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PRKAA1(1), PRKAA2(26), RHEB(2), RICTOR(10), RPS6(1), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), RPS6KA6(16), RPS6KB1(2), RPS6KB2(3), STK11(4), TSC1(5), TSC2(12), ULK1(8), ULK2(7), ULK3(1), VEGFA(7), VEGFB(1), VEGFC(19) 20408770 438 203 288 125 182 20 20 177 37 2 4.37e-05 1.000 1.000 107 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(3), ATF1(5), BRAF(147), CAMP(1), CREB3(1), CREB5(11), CREBBP(23), CRKL(2), DAG1(6), EGR1(4), EGR2(4), EGR3(2), EGR4(5), ELK1(2), FRS2(5), GNAQ(5), JUN(1), MAP1B(21), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(9), MAPK3(1), MAPK8(2), MAPK8IP1(5), MAPK8IP2(9), MAPK8IP3(9), MAPK9(7), NTRK1(19), OPN1LW(5), PIK3C2G(50), PIK3CA(9), PIK3CD(7), PIK3R1(7), PTPN11(10), RPS6KA3(2), SHC1(3), SRC(1), TERF2IP(2), TH(9) 19789879 426 203 286 127 195 21 17 163 29 1 7.80e-05 1.000 1.000 108 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(3), ADCY1(29), ADCY2(8), ADCY3(4), ADCY4(6), ADCY5(17), ADCY6(7), ADCY7(10), ADCY8(51), ADCY9(9), ADK(4), ADSL(7), ADSS(2), ADSSL1(8), AK1(1), AK2(3), AK5(7), AK7(22), ALLC(9), AMPD1(31), AMPD2(5), AMPD3(22), APRT(3), ATIC(5), CANT1(9), DGUOK(4), ENPP1(13), ENPP3(15), ENTPD1(11), ENTPD2(4), ENTPD3(6), ENTPD4(4), ENTPD5(2), ENTPD6(5), ENTPD8(2), FHIT(3), GART(10), GDA(13), GMPR2(2), GMPS(6), GUCY1A2(21), GUCY1A3(34), GUCY1B3(7), GUCY2C(32), GUCY2D(10), GUCY2F(16), GUK1(2), IMPDH1(2), IMPDH2(1), NME6(3), NME7(4), NPR1(18), NPR2(14), NT5C1A(3), NT5C1B(24), NT5C2(3), NT5C3(2), NT5E(4), NT5M(2), NUDT5(2), NUDT9(2), PAICS(1), PAPSS1(3), PAPSS2(5), PDE10A(13), PDE11A(19), PDE1A(37), PDE1C(44), PDE2A(14), PDE3B(6), PDE4A(9), PDE4B(7), PDE4C(18), PDE4D(8), PDE5A(8), PDE6D(2), PDE6G(2), PDE7A(2), PDE7B(17), PDE8A(3), PDE8B(21), PDE9A(10), PFAS(9), PKLR(11), PKM2(5), PNPT1(2), POLA1(2), POLA2(9), POLD1(6), POLD2(2), POLD3(4), POLE(16), POLE2(3), POLR1A(11), POLR1B(9), POLR1C(1), POLR2A(12), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(5), POLR3B(15), POLR3G(1), POLR3GL(1), POLR3H(2), POLR3K(1), PRIM1(3), PRIM2(15), PRPS1(2), PRPS1L1(14), PRPS2(4), PRUNE(2), RRM1(3), RRM2(2), RRM2B(3), XDH(56), ZNRD1(1) 63262995 1090 200 1039 543 756 88 51 106 89 0 0.000953 1.000 1.000 109 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 110 ABL1(12), ANAPC1(17), ANAPC10(1), ANAPC2(5), ANAPC4(4), ANAPC5(7), ANAPC7(6), ATM(13), ATR(25), BUB1(6), BUB1B(9), CCNA1(18), CCNB2(3), CCNB3(29), CCND1(1), CCND2(5), CCND3(2), CCNE1(4), CCNE2(14), CCNH(2), CDC14A(5), CDC14B(1), CDC16(2), CDC20(1), CDC23(3), CDC25A(8), CDC25B(6), CDC25C(5), CDC27(10), CDC6(1), CDC7(3), CDK4(5), CDK6(3), CDKN1A(4), CDKN1B(1), CDKN2A(34), CDKN2C(1), CHEK1(2), CHEK2(2), CREBBP(23), CUL1(7), DBF4(5), E2F1(7), E2F2(4), E2F3(6), EP300(14), ESPL1(14), FZR1(7), GADD45B(2), GADD45G(1), GSK3B(2), HDAC1(1), HDAC2(1), MAD1L1(5), MAD2L1(1), MAD2L2(1), MCM2(11), MCM3(10), MCM4(7), MCM5(4), MCM6(5), MDM2(4), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), PKMYT1(3), PLK1(3), PRKDC(20), PTTG1(1), PTTG2(5), RB1(8), RBL1(11), RBL2(6), SFN(1), SKP2(2), SMAD2(3), SMAD3(2), SMAD4(2), SMC1A(3), SMC1B(21), TFDP1(3), TGFB1(1), TGFB2(1), TGFB3(3), TP53(43), WEE1(3), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3) 52898509 588 200 543 199 307 43 43 106 87 2 3.69e-05 1.000 1.000 110 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(1), CALM2(1), CALML3(6), CDS1(11), CDS2(4), DGKA(4), DGKB(24), DGKD(11), DGKE(7), DGKG(18), DGKH(8), DGKI(26), DGKQ(6), DGKZ(8), IMPA1(2), IMPA2(2), INPP1(2), INPP4A(6), INPP4B(4), INPP5A(4), INPP5B(6), INPP5D(37), INPPL1(15), ITGB1BP3(2), ITPK1(6), ITPKA(1), ITPKB(6), ITPR1(36), ITPR2(18), ITPR3(9), OCRL(5), PI4KA(18), PI4KB(4), PIK3C2A(8), PIK3C2B(14), PIK3C2G(50), PIK3C3(3), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PIP4K2A(5), PIP4K2B(3), PIP4K2C(3), PIP5K1A(6), PIP5K1B(20), PIP5K1C(8), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), PLCD1(4), PLCD3(3), PLCD4(4), PLCE1(53), PLCG1(9), PLCG2(25), PLCZ1(26), PRKCA(11), PRKCG(14), PTEN(23), SYNJ1(23), SYNJ2(16) 47912010 885 198 822 395 590 50 39 114 90 2 4.09e-05 1.000 1.000 111 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(3), AKT2(8), AKT3(4), BCL10(3), CARD11(35), CBL(11), CBLB(19), CBLC(15), CD247(3), CD28(1), CD3D(5), CD3E(2), CD3G(1), CD4(6), CD40LG(2), CD8A(2), CD8B(8), CDC42(3), CDK4(5), CHP(3), CHUK(2), CSF2(2), CTLA4(2), FOS(2), FYN(7), GRAP2(5), GRB2(2), HRAS(4), ICOS(3), IFNG(2), IKBKB(4), IL10(3), IL2(4), IL4(1), IL5(4), ITK(21), JUN(1), KRAS(4), LAT(1), LCK(14), LCP2(10), MALT1(8), MAP3K14(4), NCK1(1), NCK2(6), NFAT5(8), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB1(7), NFKB2(5), NFKBIA(2), NFKBIB(1), NRAS(73), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PAK7(48), PDCD1(3), PDK1(2), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(8), PRKCQ(18), PTPN6(3), PTPRC(33), RASGRP1(9), RHOA(1), SOS1(9), SOS2(13), TEC(10), TNF(1), VAV1(16), VAV2(4), VAV3(10), ZAP70(7) 39258673 740 197 642 304 424 51 58 143 63 1 0.00302 1.000 1.000 112 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(5), ACTN2(24), ACTN3(7), ACTN4(5), ARHGAP5(12), BCAR1(5), CD99(2), CDC42(3), CDH5(12), CLDN1(5), CLDN10(5), CLDN11(5), CLDN14(5), CLDN16(7), CLDN17(6), CLDN18(7), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(1), CLDN4(10), CLDN6(9), CLDN7(1), CLDN8(3), CLDN9(1), CTNNA1(2), CTNNA2(27), CTNNA3(30), CTNNB1(13), CTNND1(9), CXCL12(2), CXCR4(4), CYBA(1), CYBB(7), ESAM(3), EZR(1), F11R(5), GNAI1(1), GNAI2(5), GNAI3(3), GRLF1(12), ICAM1(3), ITGA4(38), ITGAL(24), ITGAM(21), ITGB1(4), ITGB2(14), ITK(21), JAM2(10), JAM3(2), MAPK11(1), MAPK12(2), MAPK13(5), MAPK14(5), MLLT4(13), MMP2(7), MMP9(8), MSN(1), MYL2(5), MYL5(1), MYL7(2), MYL9(2), MYLPF(2), NCF1(1), NCF2(7), NCF4(4), NOX1(11), NOX3(9), OCLN(4), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PLCG1(9), PLCG2(25), PRKCA(11), PRKCG(14), PTK2(8), PTK2B(11), PTPN11(10), PXN(3), RAC1(17), RAC2(1), RAP1A(2), RAP1B(1), RAPGEF3(13), RAPGEF4(14), RASSF5(6), RHOA(1), RHOH(5), ROCK1(5), ROCK2(13), SIPA1(8), THY1(1), TXK(10), VASP(3), VAV1(16), VAV2(4), VAV3(10), VCAM1(18), VCL(7) 47811209 844 197 793 409 558 57 30 112 84 3 0.00130 1.000 1.000 113 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(3), APC(22), AR(7), BRAF(147), CAMP(1), CCL13(1), CCL15(3), CCL16(1), DAG1(6), EGFR(23), GNA11(7), GNA15(5), GNAI1(1), GNAQ(5), ITPKA(1), ITPKB(6), ITPR1(36), ITPR2(18), ITPR3(9), KCNJ3(22), KCNJ5(15), KCNJ9(4), MAPK1(4), MAPK10(9), MAPK14(5), PHKA2(7), PIK3CA(9), PIK3CD(7), PIK3R1(7), PITX2(4), PTX3(1), RAF1(8), SRC(1) 20569764 405 196 267 149 169 22 22 161 30 1 0.0137 1.000 1.000 114 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(17), AMY2A(5), AMY2B(10), ASCC3(11), ATP13A2(10), DDX18(4), DDX19A(1), DDX23(5), DDX4(11), DDX41(6), DDX47(1), DDX50(5), DDX51(5), DDX52(4), DDX54(2), DDX55(3), DDX56(3), DHX58(4), ENPP1(13), ENPP3(15), ENTPD7(2), EP400(25), ERCC2(2), ERCC3(5), G6PC(7), G6PC2(7), GAA(7), GANC(6), GBA(5), GBA3(14), GBE1(9), GCK(20), GPI(3), GUSB(4), GYS1(3), GYS2(22), HK1(3), HK2(12), HK3(15), IFIH1(13), MGAM(142), MOV10L1(28), NUDT5(2), NUDT8(1), PGM1(4), PGM3(4), PYGB(2), PYGL(9), PYGM(10), RAD54B(6), RUVBL2(4), SETX(17), SI(81), SKIV2L2(4), SMARCA2(11), SMARCA5(5), TREH(3), UGDH(1), UGP2(2), UGT1A1(5), UGT1A10(15), UGT1A3(12), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(12), UGT1A8(7), UGT1A9(11), UGT2A1(22), UGT2A3(24), UGT2B10(38), UGT2B11(22), UGT2B15(29), UGT2B28(26), UGT2B4(36), UGT2B7(21), UXS1(4) 47546062 963 194 899 420 659 81 39 88 95 1 0.000137 1.000 1.000 115 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(6), AKR1C1(3), AKR1C2(4), AKR1C3(12), AKR1C4(9), ALDH1A3(2), ALDH3A1(7), ALDH3B1(2), ALDH3B2(7), CYP1A1(10), CYP1A2(12), CYP1B1(2), CYP2B6(16), CYP2C18(26), CYP2C19(42), CYP2C8(31), CYP2C9(38), CYP2E1(13), CYP2F1(11), CYP2S1(10), CYP3A4(20), CYP3A43(16), CYP3A5(10), CYP3A7(21), DHDH(5), EPHX1(2), GSTA1(5), GSTA2(2), GSTA3(1), GSTA5(3), GSTK1(2), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTP1(2), GSTT1(1), MGST1(2), MGST2(2), MGST3(1), UGT1A1(5), UGT1A10(15), UGT1A3(12), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(12), UGT1A8(7), UGT1A9(11), UGT2A1(22), UGT2A3(24), UGT2B10(38), UGT2B11(22), UGT2B15(29), UGT2B28(26), UGT2B4(36), UGT2B7(21) 22138444 791 193 717 340 581 56 38 52 63 1 5.76e-09 1.000 1.000 116 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(3), AKT2(8), AKT3(4), BTK(17), CSF2(2), FCER1A(14), FCER1G(1), FYN(7), GAB2(4), GRB2(2), HRAS(4), IL13(2), IL3(3), IL4(1), IL5(4), INPP5D(37), KRAS(4), LAT(1), LCP2(10), LYN(7), MAP2K1(13), MAP2K2(4), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(4), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(2), MAPK13(5), MAPK14(5), MAPK3(1), MAPK8(2), MAPK9(7), MS4A2(10), NRAS(73), PDK1(2), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(7), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), PLCG1(9), PLCG2(25), PRKCA(11), PRKCD(4), PRKCE(6), RAC1(17), RAC2(1), RAF1(8), SOS1(9), SOS2(13), SYK(16), TNF(1), VAV1(16), VAV2(4), VAV3(10) 27933880 602 191 497 213 340 31 49 125 56 1 1.54e-06 1.000 1.000 117 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(18), CD14(5), CD19(7), CD1A(11), CD1B(13), CD1C(23), CD1D(8), CD1E(22), CD2(23), CD22(26), CD33(18), CD34(4), CD36(4), CD37(3), CD38(4), CD3D(5), CD3E(2), CD3G(1), CD4(6), CD44(6), CD5(7), CD55(4), CD59(1), CD8A(2), CD8B(8), CR1(54), CR2(33), CSF1(11), CSF1R(13), CSF2(2), CSF2RA(20), CSF3(5), CSF3R(8), DNTT(10), EPO(6), EPOR(1), FCER2(3), FCGR1A(6), FLT3(31), FLT3LG(2), GP5(4), GP9(6), GYPA(8), HLA-DRA(11), HLA-DRB1(4), HLA-DRB5(1), IL11(2), IL11RA(3), IL1A(4), IL1B(7), IL1R1(12), IL1R2(9), IL2RA(4), IL3(3), IL3RA(8), IL4(1), IL4R(14), IL5(4), IL5RA(14), IL6(2), IL6R(4), IL7(5), IL7R(33), IL9R(6), ITGA1(18), ITGA2(14), ITGA2B(11), ITGA3(7), ITGA4(38), ITGA5(25), ITGA6(8), ITGAM(21), ITGB3(12), KIT(10), KITLG(9), MME(21), MS4A1(8), TFRC(5), THPO(8), TNF(1), TPO(45) 31456854 866 190 812 398 625 48 33 67 93 0 0.000506 1.000 1.000 118 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(3), AKT2(8), AKT3(4), BCL10(3), BLNK(14), BTK(17), CARD11(35), CD19(7), CD22(26), CD72(4), CD79A(2), CD79B(1), CD81(2), CHP(3), CHUK(2), CR2(33), FCGR2B(3), FOS(2), GSK3B(2), HRAS(4), IKBKB(4), INPP5D(37), JUN(1), KRAS(4), LILRB3(6), LYN(7), MALT1(8), NFAT5(8), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB1(7), NFKB2(5), NFKBIA(2), NFKBIB(1), NRAS(73), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PLCG2(25), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(8), PTPN6(3), RAC1(17), RAC2(1), RASGRP3(15), SYK(16), VAV1(16), VAV2(4), VAV3(10) 28845067 606 190 513 214 344 30 55 119 57 1 9.43e-07 1.000 1.000 119 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(3), AKT3(4), BCAR1(5), CAPN1(4), CAPN10(8), CAPN11(11), CAPN2(6), CAPN3(9), CAPN5(7), CAPN6(14), CAPN7(2), CAPN9(13), CAPNS1(1), CAV1(2), CDC42(3), CRK(3), CSK(1), DOCK1(15), FYN(7), GIT2(9), GRB2(2), ITGA10(10), ITGA11(17), ITGA2(14), ITGA2B(11), ITGA3(7), ITGA4(38), ITGA5(25), ITGA6(8), ITGA7(25), ITGA8(36), ITGA9(14), ITGAD(26), ITGAE(19), ITGAL(24), ITGAM(21), ITGAV(9), ITGAX(20), ITGB1(4), ITGB2(14), ITGB3(12), ITGB4(22), ITGB5(7), ITGB6(12), ITGB7(6), ITGB8(17), MAP2K1(13), MAP2K2(4), MAP2K3(9), MAP2K6(3), MAPK10(9), MAPK12(2), MAPK4(18), MAPK6(6), MAPK7(4), MYLK2(13), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PDPK1(4), PIK3R2(5), PTK2(8), PXN(3), RAC1(17), RAC2(1), RAP1B(1), RAPGEF1(10), RHO(2), ROCK1(5), ROCK2(13), SDCCAG8(5), SEPP1(1), SHC1(3), SHC3(12), SORBS1(13), SOS1(9), SRC(1), TLN1(14), TNS1(9), VASP(3), VAV2(4), VAV3(10), VCL(7), ZYX(7) 51403789 826 190 791 370 562 54 31 107 71 1 9.30e-05 1.000 1.000 120 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(3), AKT2(8), AKT3(4), CASP9(3), CDC42(3), CHP(3), HRAS(4), KDR(45), KRAS(4), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK11(1), MAPK12(2), MAPK13(5), MAPK14(5), MAPK3(1), MAPKAPK2(5), MAPKAPK3(4), NFAT5(8), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NOS3(17), NRAS(73), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(7), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), PLCG1(9), PLCG2(25), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(8), PRKCA(11), PRKCG(14), PTGS2(11), PTK2(8), PXN(3), RAC1(17), RAC2(1), RAF1(8), SH2D2A(3), SHC2(7), SPHK1(1), SPHK2(7), SRC(1), VEGFA(7) 27897073 577 188 476 220 331 24 44 125 52 1 6.02e-05 1.000 1.000 121 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(11), ABCA10(21), ABCA12(66), ABCA13(67), ABCA2(9), ABCA3(18), ABCA4(51), ABCA5(9), ABCA6(27), ABCA7(12), ABCA8(32), ABCA9(21), ABCB1(41), ABCB10(5), ABCB11(46), ABCB4(19), ABCB5(40), ABCB6(2), ABCB7(6), ABCB8(3), ABCB9(6), ABCC1(12), ABCC10(12), ABCC11(18), ABCC12(24), ABCC2(10), ABCC3(28), ABCC4(11), ABCC5(8), ABCC6(27), ABCC8(39), ABCC9(60), ABCD2(18), ABCD3(10), ABCD4(1), ABCG1(11), ABCG2(7), ABCG4(7), ABCG5(6), ABCG8(17), CFTR(46), TAP1(2), TAP2(13) 45614185 899 186 857 525 609 72 31 97 90 0 0.0292 1.000 1.000 122 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(3), AKT2(8), AKT3(4), CASP8(9), CD14(5), CD40(4), CD80(5), CD86(21), CHUK(2), CXCL10(3), CXCL11(1), CXCL9(3), FOS(2), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(10), IFNA17(2), IFNA2(1), IFNA21(9), IFNA4(1), IFNA5(3), IFNA6(3), IFNA7(5), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IKBKB(4), IKBKE(12), IL12A(3), IL12B(4), IL1B(7), IL6(2), IL8(1), IRAK1(5), IRAK4(3), IRF3(4), IRF5(5), IRF7(7), JUN(1), LBP(9), LY96(4), MAP2K1(13), MAP2K2(4), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(4), MAP3K7(1), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(2), MAPK13(5), MAPK14(5), MAPK3(1), MAPK8(2), MAPK9(7), MYD88(3), NFKB1(7), NFKB2(5), NFKBIA(2), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), RAC1(17), RELA(5), RIPK1(1), SPP1(7), STAT1(4), TBK1(5), TICAM1(9), TIRAP(1), TLR1(11), TLR2(17), TLR3(10), TLR4(34), TLR5(19), TLR6(6), TLR7(16), TLR8(12), TLR9(14), TNF(1), TOLLIP(1), TRAF3(5), TRAF6(5) 34660442 588 186 552 261 376 36 29 91 55 1 0.000955 1.000 1.000 123 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(3), ADCY1(29), ADCY2(8), ADCY3(4), ADCY4(6), ADCY5(17), ADCY6(7), ADCY7(10), ADCY8(51), ADK(4), ADSL(7), ADSS(2), AK1(1), AK2(3), AK5(7), ALLC(9), AMPD1(31), AMPD2(5), AMPD3(22), APRT(3), ATIC(5), ATP1B1(1), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(6), ATP5G2(1), ATP5H(1), ATP5J(2), CANT1(9), DGUOK(4), ENPP1(13), ENPP3(15), ENTPD1(11), ENTPD2(4), FHIT(3), GART(10), GDA(13), GMPS(6), GUCY1A2(21), GUCY1A3(34), GUCY1B3(7), GUCY2C(32), GUCY2D(10), GUCY2F(16), GUK1(2), IMPDH1(2), IMPDH2(1), NPR1(18), NPR2(14), NT5E(4), NT5M(2), PAICS(1), PAPSS1(3), PAPSS2(5), PDE1A(37), PDE4A(9), PDE4B(7), PDE4C(18), PDE4D(8), PDE5A(8), PDE6B(15), PDE6C(27), PDE6G(2), PDE7B(17), PDE8A(3), PDE9A(10), PFAS(9), PKLR(11), PKM2(5), POLD1(6), POLD2(2), POLE(16), POLG(9), POLL(7), POLQ(25), POLR1B(9), POLR2A(12), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(2), PRPS1(2), PRPS1L1(14), PRPS2(4), PRUNE(2), RRM1(3), RRM2(2) 49500205 831 185 780 419 583 68 28 78 74 0 0.00176 1.000 1.000 124 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(12), ATM(13), BUB1(6), BUB1B(9), CCNA1(18), CCNB2(3), CCNB3(29), CCND2(5), CCND3(2), CCNE1(4), CCNE2(14), CCNH(2), CDAN1(5), CDC14A(5), CDC14B(1), CDC20(1), CDC25A(8), CDC25B(6), CDC25C(5), CDC6(1), CDC7(3), CDH1(7), CDK4(5), CDKN1A(4), CDKN2A(34), CHEK1(2), CHEK2(2), DTX4(4), E2F1(7), E2F2(4), E2F3(6), E2F4(1), E2F5(1), EP300(14), ESPL1(14), GSK3B(2), HDAC1(1), HDAC2(1), HDAC3(6), HDAC4(10), HDAC5(7), HDAC6(2), HDAC8(3), MAD1L1(5), MAD2L1(1), MAD2L2(1), MCM2(11), MCM3(10), MCM4(7), MCM5(4), MCM6(5), MDM2(4), MPEG1(7), MPL(8), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), PLK1(3), PRKDC(20), PTPRA(7), PTTG1(1), PTTG2(5), RB1(8), RBL1(11), SKP2(2), SMAD4(2), TBC1D8(9), TFDP1(3), TGFB1(1), TP53(43), WEE1(3) 42530976 485 183 446 179 267 39 25 78 74 2 0.000276 1.000 1.000 125 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(3), ACTB(7), ACTG1(5), ACTN1(5), ACTN2(24), ACTN3(7), ACTN4(5), ACVR1B(3), ACVR1C(9), BAIAP2(7), CDC42(3), CDH1(7), CREBBP(23), CSNK2A1(1), CSNK2A2(1), CSNK2B(2), CTNNA1(2), CTNNA2(27), CTNNA3(30), CTNNB1(13), CTNND1(9), EGFR(23), EP300(14), ERBB2(7), FARP2(6), FER(3), FGFR1(11), FYN(7), IGF1R(11), INSR(22), IQGAP1(10), LEF1(3), LMO7(27), MAP3K7(1), MAPK1(4), MAPK3(1), MET(23), MLLT4(13), NLK(6), PARD3(17), PTPN1(4), PTPN6(3), PTPRB(91), PTPRF(28), PTPRJ(12), PTPRM(8), PVRL1(4), PVRL2(6), PVRL3(5), PVRL4(7), RAC1(17), RAC2(1), RHOA(1), SMAD2(3), SMAD3(2), SMAD4(2), SNAI1(2), SNAI2(4), SORBS1(13), SRC(1), SSX2IP(5), TCF7(2), TCF7L1(3), TCF7L2(7), TGFBR2(7), TJP1(11), VCL(7), WAS(7), WASF1(5), WASF2(5), WASF3(12), WASL(5), YES1(5) 46547894 697 183 656 331 464 48 28 81 73 3 0.0899 1.000 1.000 126 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(28), ASH2L(3), CARM1(6), CTCFL(23), DOT1L(11), EED(4), EHMT1(8), EHMT2(9), EZH1(6), EZH2(14), FBXO11(6), HCFC1(17), HSF4(2), JMJD4(4), JMJD6(2), KDM6A(4), MEN1(4), MLL(40), MLL2(54), MLL3(66), MLL4(34), MLL5(12), NSD1(17), OGT(10), PAXIP1(4), PPP1CA(2), PPP1CB(5), PPP1CC(2), PRDM2(13), PRDM7(6), PRDM9(52), PRMT1(2), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), RBBP5(5), SATB1(14), SETD1A(24), SETD2(15), SETD7(3), SETD8(1), SETDB1(10), SETDB2(5), SETMAR(4), SMYD3(3), STK38(4), SUV39H1(1), SUV39H2(2), SUV420H1(8), SUV420H2(2), SUZ12(2), WHSC1(10), WHSC1L1(7) 45763017 607 182 583 212 388 58 23 80 58 0 0.00103 1.000 1.000 127 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 A4GNT(6), ALG1(2), ALG10(4), ALG10B(4), ALG12(1), ALG13(9), ALG14(2), ALG2(4), ALG3(4), ALG6(3), ALG8(6), ALG9(5), B3GNT1(2), B3GNT2(2), B3GNT7(4), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT4(3), B4GALT5(3), C1GALT1(6), C1GALT1C1(2), CHPF(4), CHST1(9), CHST11(5), CHST12(4), CHST13(3), CHST14(3), CHST2(4), CHST3(1), CHST4(11), CHST6(4), CHSY1(8), DAD1(1), DDOST(3), DPAGT1(2), EXT1(2), EXT2(6), EXTL1(2), EXTL3(11), FUT11(3), FUT8(8), GALNT1(4), GALNT10(6), GALNT11(3), GALNT12(9), GALNT13(29), GALNT14(27), GALNT2(6), GALNT3(3), GALNT4(6), GALNT5(9), GALNT6(17), GALNT7(5), GALNT8(24), GALNT9(5), GALNTL1(5), GALNTL2(23), GALNTL4(6), GALNTL5(14), GANAB(5), GCNT1(7), GCNT3(7), GCNT4(4), HS2ST1(1), HS3ST1(11), HS3ST2(8), HS3ST3A1(4), HS3ST3B1(2), HS3ST5(8), HS6ST1(3), HS6ST2(3), HS6ST3(16), MAN1A1(17), MAN1A2(6), MAN1B1(4), MAN1C1(8), MAN2A1(10), MGAT1(3), MGAT2(3), MGAT3(10), MGAT4A(8), MGAT4B(1), MGAT5(5), MGAT5B(10), NDST1(4), NDST2(2), NDST3(25), NDST4(50), OGT(10), RPN2(2), ST3GAL1(6), ST3GAL2(1), ST3GAL3(2), ST3GAL4(1), ST6GAL1(5), ST6GALNAC1(5), STT3B(7), WBSCR17(39), XYLT1(13), XYLT2(3) 42286215 713 180 679 385 481 58 31 72 71 0 0.0941 1.000 1.000 128 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(17), AMY2A(5), AMY2B(10), ENPP1(13), ENPP3(15), G6PC(7), GAA(7), GANAB(5), GBA3(14), GBE1(9), GCK(20), GPI(3), GUSB(4), GYS1(3), GYS2(22), HK1(3), HK2(12), HK3(15), MGAM(142), PGM1(4), PGM3(4), PYGB(2), PYGL(9), PYGM(10), SI(81), UCHL1(5), UCHL3(2), UGDH(1), UGT1A1(5), UGT1A10(15), UGT1A3(12), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(12), UGT1A8(7), UGT1A9(11), UGT2B15(29), UGT2B4(36), UXS1(4) 21954504 599 179 556 257 418 61 25 47 47 1 0.000243 1.000 1.000 129 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(4), ACVR1B(3), ACVRL1(9), AKT1(3), AURKB(2), BMPR1A(2), BMPR2(6), BUB1(6), CDKL1(5), CDKL2(2), CDS1(11), CDS2(4), CLK1(4), CLK2(6), COL4A3BP(4), CSNK2A1(1), CSNK2A2(1), CSNK2B(2), DGKA(4), DGKB(24), DGKD(11), DGKE(7), DGKG(18), DGKH(8), DGKQ(6), DGKZ(8), IMPA1(2), INPP1(2), INPP4A(6), INPP4B(4), INPP5A(4), INPPL1(15), ITPKA(1), ITPKB(6), MAP3K10(8), MOS(5), NEK1(9), NEK3(2), OCRL(5), PAK4(4), PIK3C2A(8), PIK3C2B(14), PIK3C2G(50), PIK3CA(9), PIK3CB(26), PIK3CG(25), PIM2(4), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), PLCD1(4), PLCG1(9), PLCG2(25), PLK3(4), PRKACA(4), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(11), PRKCD(4), PRKCE(6), PRKCG(14), PRKCH(11), PRKCQ(18), PRKCZ(6), PRKD1(3), PRKG1(13), RAF1(8), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), RPS6KA4(4), RPS6KB1(2), STK11(4), VRK1(1) 43478447 704 178 660 378 471 40 29 90 73 1 0.522 1.000 1.000 130 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(11), AGTR2(12), ATP8A1(22), AVPR1A(4), AVPR1B(9), AVPR2(1), BDKRB1(5), BDKRB2(10), BRS3(5), C3AR1(5), CCKAR(10), CCKBR(12), CCR1(10), CCR10(2), CCR2(17), CCR3(11), CCR4(8), CCR5(7), CCR6(3), CCR7(3), CCR8(6), CX3CR1(13), CXCR3(5), CXCR4(4), CXCR6(4), EDNRA(9), EDNRB(5), FPR1(20), FSHR(19), GALR1(5), GALR2(1), GALR3(2), GALT(2), GHSR(11), GNB2L1(3), GNRHR(2), GPR77(5), GRPR(5), LHCGR(27), MC2R(5), MC3R(7), MC4R(1), MC5R(7), NMBR(8), NPY1R(25), NPY2R(14), NPY5R(24), NTSR1(6), NTSR2(3), OPRD1(2), OPRK1(23), OPRL1(5), OPRM1(5), OXTR(5), PPYR1(12), SSTR1(11), SSTR2(6), SSTR3(12), SSTR4(4), TACR1(8), TACR2(8), TACR3(28), TRHR(21), TSHR(11) 20265740 576 177 545 396 398 52 23 60 43 0 0.00240 1.000 1.000 131 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 IMPA1(2), IMPA2(2), INPP1(2), INPP4A(6), INPP4B(4), INPP5A(4), INPP5B(6), INPPL1(15), IPMK(2), ISYNA1(2), ITGB1BP3(2), ITPK1(6), ITPKA(1), ITPKB(6), MINPP1(1), MIOX(3), OCRL(5), PI4KA(18), PI4KB(4), PIK3C3(3), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIP4K2A(5), PIP4K2B(3), PIP4K2C(3), PIP5K1A(6), PIP5K1B(20), PIP5K1C(8), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), PLCD1(4), PLCD3(3), PLCD4(4), PLCE1(53), PLCG1(9), PLCG2(25), PLCZ1(26), PTEN(23), SYNJ1(23), SYNJ2(16) 28562649 533 174 496 226 341 28 27 80 56 1 0.000502 1.000 1.000 132 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(9), AKR1D1(20), ARSD(3), ARSE(5), CARM1(6), CYP11B1(16), CYP11B2(14), CYP19A1(12), HEMK1(5), HSD11B1(11), HSD11B2(2), HSD17B12(2), HSD17B2(10), HSD17B3(6), HSD17B7(2), HSD3B1(10), HSD3B2(11), LCMT1(4), METTL2B(8), METTL6(3), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), SRD5A1(3), SRD5A2(7), STS(7), SULT1E1(16), SULT2A1(8), SULT2B1(7), UGT1A1(5), UGT1A10(15), UGT1A3(12), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(12), UGT1A8(7), UGT1A9(11), UGT2A1(22), UGT2A3(24), UGT2B10(38), UGT2B11(22), UGT2B15(29), UGT2B28(26), UGT2B4(36), UGT2B7(21), WBSCR22(1) 19310554 536 171 494 219 373 50 25 36 51 1 9.34e-07 1.000 1.000 133 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(1), AKT1(3), AKT2(8), AKT3(4), APAF1(6), ATM(13), BAX(3), BCL2(2), BIRC2(5), BIRC3(8), CAPN1(4), CAPN2(6), CASP10(5), CASP3(2), CASP7(5), CASP8(9), CASP9(3), CFLAR(4), CHP(3), CHUK(2), CSF2RB(18), CYCS(1), DFFA(2), DFFB(3), FAS(5), FASLG(14), IKBKB(4), IL1A(4), IL1B(7), IL1R1(12), IL1RAP(4), IL3(3), IL3RA(8), IRAK1(5), IRAK2(14), IRAK3(7), IRAK4(3), MAP3K14(4), MYD88(3), NFKB1(7), NFKB2(5), NFKBIA(2), NTRK1(19), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(8), PRKACA(4), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RELA(5), RIPK1(1), TNF(1), TNFRSF10A(5), TNFRSF10B(3), TNFRSF10C(4), TNFRSF10D(8), TNFRSF1A(3), TNFSF10(8), TP53(43), TRAF2(3) 32196532 476 171 453 227 278 32 24 77 64 1 0.197 1.000 1.000 134 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(4), ACVR1B(3), ACVR1C(9), ACVR2A(3), ACVR2B(3), ACVRL1(9), AMHR2(16), BMP2(6), BMP4(3), BMP5(27), BMP6(11), BMP7(2), BMP8A(2), BMP8B(2), BMPR1A(2), BMPR1B(4), BMPR2(6), CHRD(14), COMP(7), CREBBP(23), CUL1(7), DCN(17), E2F4(1), E2F5(1), EP300(14), FST(4), GDF5(14), GDF6(2), GDF7(2), ID2(2), IFNG(2), INHBA(19), INHBB(8), INHBC(11), INHBE(3), LEFTY1(8), LEFTY2(3), LTBP1(45), MAPK1(4), MAPK3(1), MYC(5), NODAL(2), NOG(1), PITX2(4), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(4), PPP2R2A(2), PPP2R2B(6), PPP2R2C(6), RBL1(11), RBL2(6), RHOA(1), ROCK1(5), ROCK2(13), RPS6KB1(2), RPS6KB2(3), SMAD1(6), SMAD2(3), SMAD3(2), SMAD4(2), SMAD5(3), SMAD6(7), SMAD7(3), SMAD9(10), SMURF1(1), SMURF2(9), SP1(5), TFDP1(3), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(7), THBS1(30), THBS2(10), THBS3(11), THBS4(11), TNF(1), ZFYVE16(4), ZFYVE9(8) 38421037 541 171 523 260 355 47 21 63 55 0 0.255 1.000 1.000 135 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(62), COL4A2(33), COL4A3(41), COL4A4(97), COL4A5(56), COL4A6(35), F10(10), F11(15), F12(1), F2(9), F2R(7), F5(37), F8(46), F9(12), FGA(42), FGB(10), FGG(8), KLKB1(25), PROC(9), PROS1(13), SERPINC1(8), SERPING1(12) 17202012 588 171 552 183 449 40 22 48 29 0 0.0572 1.000 1.000 136 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(6), AGK(6), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPAT6(3), AKR1A1(3), AKR1B1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3), CEL(13), DAK(3), DGAT1(1), DGAT2(7), DGKA(4), DGKB(24), DGKD(11), DGKE(7), DGKG(18), DGKH(8), DGKI(26), DGKQ(6), DGKZ(8), GK(6), GK2(38), GLA(1), GLB1(8), GPAM(5), LCT(43), LIPA(4), LIPC(9), LIPF(15), LIPG(6), LPL(3), MGLL(6), PNLIP(8), PNLIPRP1(10), PNLIPRP2(3), PNPLA3(2), PPAP2B(9), PPAP2C(8) 22797805 508 169 458 222 351 48 18 57 34 0 0.000116 1.000 1.000 137 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 65 ATM(13), CCNA1(18), CCND1(1), CCND2(5), CCND3(2), CCNE1(4), CCNE2(14), CCNH(2), CDC25A(8), CDK4(5), CDKN1A(4), CDKN1B(1), CDKN2A(34), CDKN2C(1), CREB3(1), CREB3L1(6), CREB3L3(10), CREB3L4(5), E2F1(7), E2F2(4), E2F3(6), E2F4(1), E2F5(1), GBA2(2), MCM2(11), MCM3(10), MCM4(7), MCM5(4), MCM6(5), MDM2(4), MNAT1(2), MYC(5), MYT1(22), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), POLA2(9), POLE(16), POLE2(3), PRIM1(3), RB1(8), RBL1(11), RPA1(3), RPA2(2), RPA3(1), TFDP1(3), TFDP2(4), TNXB(143), TP53(43), WEE1(3) 30606044 492 167 447 183 286 31 19 80 74 2 0.000141 1.000 1.000 138 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(3), AKT2(8), AKT3(4), CDC42(3), CDKN1B(1), CDKN2A(34), CREB3(1), CREB5(11), ERBB4(50), F2RL2(6), GAB1(4), GRB2(2), GSK3B(2), IFI27(2), IGF1(11), IGFBP1(3), INPPL1(15), IRS1(6), IRS2(2), IRS4(12), MET(23), MYC(5), NOLC1(4), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PAK7(48), PARD3(17), PARD6A(2), PDK1(2), PIK3CA(9), PIK3CD(7), PPP1R13B(8), PREX1(7), PTEN(23), PTK2(8), PTPN1(4), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(3), SLC2A4(8), SOS1(9), SOS2(13), TSC1(5), TSC2(12), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3) 29941141 456 167 419 198 252 39 24 62 78 1 0.0464 1.000 1.000 139 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(6), ATM(13), ATR(25), BAI1(16), BAX(3), CASP3(2), CASP8(9), CASP9(3), CCNB2(3), CCNB3(29), CCND1(1), CCND2(5), CCND3(2), CCNE1(4), CCNE2(14), CCNG1(1), CDK4(5), CDK6(3), CDKN1A(4), CDKN2A(34), CHEK1(2), CHEK2(2), CYCS(1), DDB2(3), EI24(3), FAS(5), GADD45B(2), GADD45G(1), GTSE1(11), IGF1(11), IGFBP3(2), LRDD(5), MDM2(4), MDM4(2), PERP(2), PPM1D(2), PTEN(23), RFWD2(5), RPRM(1), RRM2(2), RRM2B(3), SERPINB5(8), SERPINE1(5), SESN2(7), SESN3(1), SFN(1), STEAP3(8), THBS1(30), TNFRSF10B(3), TP53(43), TP53I3(3), TP73(5), TSC2(12), ZMAT3(1) 25128087 401 166 361 146 209 24 27 60 80 1 0.00178 1.000 1.000 140 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(2), CDC40(4), CLK2(6), CLK3(4), COL2A1(30), CPSF1(7), CPSF2(2), CPSF3(5), CSTF1(5), CSTF2(4), CSTF2T(4), CSTF3(5), DDIT3(2), DDX1(2), DDX20(8), DHX15(4), DHX16(8), DHX38(9), DHX8(11), DHX9(9), DICER1(18), DNAJC8(2), GIPC1(5), LOC440563(24), LSM2(2), LSM7(1), METTL3(2), NCBP1(1), NONO(10), NUDT21(3), NXF1(5), PABPN1(1), PAPOLA(4), PHF5A(1), POLR2A(12), PPM1G(2), PRPF18(4), PRPF3(4), PRPF4(4), PRPF4B(5), PRPF8(14), PSKH1(2), PTBP1(1), PTBP2(7), RBM17(1), RBM5(9), RNGTT(3), RNMT(8), RNPS1(1), SF3A1(7), SF3A2(6), SF3A3(4), SF3B1(15), SF3B2(9), SF3B4(5), SF4(8), SFRS12(3), SFRS14(13), SFRS16(5), SFRS4(2), SFRS5(3), SFRS6(2), SFRS7(4), SFRS8(7), SFRS9(2), SNRPA(2), SNRPA1(2), SNRPB(5), SNRPB2(1), SNRPD1(1), SNRPE(2), SNRPN(6), SNURF(3), SPOP(2), SRPK1(8), SRPK2(2), SRRM1(10), SUPT5H(7), TXNL4A(1), U2AF2(4), XRN2(5) 41223267 443 165 433 198 270 38 23 60 52 0 0.581 1.000 1.000 141 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(6), ACADL(4), ACADM(6), ACOX1(7), ACOX2(7), ACOX3(13), ACSL1(6), ACSL3(6), ACSL4(2), ACSL5(23), ACSL6(14), ADIPOQ(3), ANGPTL4(4), APOA1(2), APOA5(6), AQP7(4), CD36(4), CPT1A(11), CPT1B(10), CPT1C(15), CPT2(1), CYP27A1(4), CYP4A11(28), CYP4A22(21), CYP7A1(9), CYP8B1(13), DBI(1), EHHADH(7), FABP1(7), FABP2(6), FABP3(1), FABP4(1), FABP5(1), FADS2(4), GK(6), GK2(38), HMGCS2(18), LPL(3), ME1(20), MMP1(12), NR1H3(3), OLR1(5), PCK1(23), PCK2(4), PDPK1(4), PLTP(1), PPARA(7), PPARD(3), PPARG(11), RXRA(4), RXRB(4), RXRG(5), SCD(3), SCP2(4), SLC27A1(3), SLC27A2(14), SLC27A4(4), SLC27A5(7), SLC27A6(29), SORBS1(13), UBC(6), UCP1(4) 25427837 515 164 484 270 370 41 18 44 41 1 0.0589 1.000 1.000 142 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(7), BCL2(2), CABIN1(11), CALM1(1), CALM2(1), CAMK2B(7), CAMK4(12), CD3E(2), CD3G(1), CD69(4), CDKN1A(4), CNR1(9), CREBBP(23), CSF2(2), CSNK2A1(1), CSNK2B(2), CTLA4(2), EGR2(4), EGR3(2), EP300(14), FCER1A(14), FCGR3A(9), FOS(2), GATA3(8), GATA4(3), GRLF1(12), GSK3B(2), HRAS(4), ICOS(3), IFNA1(1), IFNB1(6), IFNG(2), IL10(3), IL13(2), IL1B(7), IL2(4), IL2RA(4), IL3(3), IL4(1), IL6(2), IL8(1), ITK(21), KPNA5(1), MAP2K7(4), MAPK14(5), MAPK8(2), MAPK9(7), MEF2A(5), MEF2B(3), MEF2D(5), MYF5(16), NCK2(6), NFAT5(8), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB2(5), NFKBIB(1), NPPB(5), NUP214(14), OPRD1(2), P2RX7(5), PAK1(4), PIN1(1), PPIA(1), PPP3CB(4), PPP3CC(2), PPP3R1(1), PTPRC(33), RELA(5), RPL13A(2), SFN(1), SLA(2), SP1(5), SP3(1), TGFB1(1), TNF(1), TRAF2(3), TRPV6(31), VAV1(16), VAV2(4), VAV3(10), XPO5(7) 35262492 500 163 481 247 339 34 21 55 51 0 0.138 1.000 1.000 143 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(12), ALG6(3), CCKBR(12), CCR2(17), CCR3(11), CCR5(7), CELSR1(25), CELSR2(24), CELSR3(33), CHRM2(19), CHRM3(22), CXCR3(5), DRD4(1), EDNRA(9), EMR2(5), EMR3(18), F2R(7), FSHR(19), GHRHR(4), GNRHR(2), GPR116(34), GPR132(3), GPR133(14), GPR135(1), GPR143(3), GPR17(1), GPR18(6), GPR55(4), GPR56(4), GPR61(8), GPR77(5), GPR84(8), GRM1(17), GRPR(5), HRH4(5), LGR6(18), LPHN2(38), LPHN3(21), LTB4R2(1), NTSR1(6), OR2M4(13), OR8G2(17), P2RY13(4), PTGFR(22), SMO(11), SSTR2(6), TAAR5(4), TSHR(11) 25751507 545 163 522 347 358 48 23 72 43 1 0.124 1.000 1.000 144 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ABP1(20), ACAT2(1), ACMSD(10), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH9A1(3), AOC2(8), AOC3(8), AOX1(24), ASMT(7), CAT(6), CYP19A1(12), CYP1A1(10), CYP1A2(12), CYP2A13(12), CYP2A6(12), CYP2A7(8), CYP2B6(16), CYP2C18(26), CYP2C19(42), CYP2C8(31), CYP2C9(38), CYP2D6(2), CYP2E1(13), CYP2F1(11), CYP2J2(7), CYP3A4(20), CYP3A5(10), CYP3A7(21), CYP4B1(21), CYP4F8(15), CYP51A1(1), DDC(12), ECHS1(2), EHHADH(7), GCDH(5), HAAO(3), HADHA(8), KMO(8), KYNU(11), MAOA(4), MAOB(13), SDS(2), TDO2(5), TPH1(9), WARS(4), WARS2(4) 21245255 566 163 533 325 428 36 22 42 38 0 0.0648 1.000 1.000 145 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(3), AKT2(8), AKT3(4), BCR(11), BTK(17), CD19(7), CDKN2A(34), DAPP1(6), FLOT1(2), GAB1(4), ITPR1(36), ITPR2(18), ITPR3(9), LYN(7), NR0B2(6), PDK1(2), PIK3CA(9), PITX2(4), PLCG2(25), PPP1R13B(8), PREX1(7), PTEN(23), PTPRC(33), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), RPS6KB1(2), SAG(9), SYK(16), TEC(10), VAV1(16) 21314015 355 162 316 168 210 21 24 37 63 0 0.0220 1.000 1.000 146 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(4), BAX(3), BFAR(1), BTK(17), CAD(18), CASP10(5), CASP3(2), CASP8(9), CASP8AP2(9), CDK2AP1(2), CSNK1A1(3), DAXX(10), DEDD(1), DEDD2(3), DFFA(2), DIABLO(1), EGFR(23), EPHB2(31), FAF1(7), FAIM2(5), HSPB1(2), IL1A(4), IL8(1), MAP2K4(4), MAP2K7(4), MAP3K1(3), MAP3K5(18), MAPK1(4), MAPK10(9), MAPK8(2), MAPK8IP1(5), MAPK8IP2(9), MAPK8IP3(9), MAPK9(7), MET(23), NFAT5(8), NFKB1(7), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), NR0B2(6), PTPN13(13), RALBP1(2), RIPK1(1), ROCK1(5), SMPD1(3), TNFRSF6B(2), TP53(43), TPX2(11), TRAF2(3), TUFM(6) 28109202 385 161 366 191 226 26 23 53 57 0 0.404 1.000 1.000 147 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACSS2(4), ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(6), AKR1A1(3), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH7A1(10), ALDH9A1(3), ALDOA(2), ALDOB(13), ALDOC(3), BPGM(3), DLAT(2), DLD(2), ENO1(4), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(7), G6PC2(7), GALM(2), GAPDH(3), GAPDHS(1), GCK(20), GPI(3), HK1(3), HK2(12), HK3(15), LDHA(6), LDHAL6A(5), LDHAL6B(7), LDHB(2), LDHC(5), PDHA1(3), PDHA2(19), PDHB(1), PFKL(4), PFKM(2), PGAM2(3), PGK1(5), PGK2(29), PGM1(4), PGM3(4), PKLR(11), PKM2(5) 22545603 402 158 361 185 279 34 19 42 28 0 0.000248 1.000 1.000 148 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(11), ADCY4(6), ADCY6(7), ADCY8(51), CACNA1A(36), CACNA1B(28), GNAS(22), GNAT3(3), GNB3(7), GRM4(20), ITPR3(9), KCNB1(37), PDE1A(37), PLCB2(10), PRKACA(4), PRKACB(4), PRKACG(8), PRKX(4), SCNN1A(7), SCNN1B(14), SCNN1G(28), TAS1R1(10), TAS1R2(25), TAS1R3(3), TAS2R1(10), TAS2R10(7), TAS2R13(3), TAS2R14(2), TAS2R16(10), TAS2R3(1), TAS2R38(16), TAS2R39(10), TAS2R4(3), TAS2R40(4), TAS2R41(15), TAS2R42(2), TAS2R43(1), TAS2R46(2), TAS2R5(4), TAS2R50(1), TAS2R60(19), TAS2R7(3), TAS2R8(5), TAS2R9(7), TRPM5(13) 21908389 529 158 494 419 367 40 21 59 42 0 0.825 1.000 1.000 149 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(3), ACTR3(2), AKT1(3), AKT2(8), AKT3(4), ANGPTL2(3), ARHGAP1(2), ARHGAP4(3), ARHGEF11(19), BTK(17), CDC42(3), CFL1(1), GDI1(1), GDI2(2), INPPL1(15), ITPR1(36), ITPR2(18), ITPR3(9), LIMK1(4), MYLK(41), MYLK2(13), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PAK7(48), PDK1(2), PIK3CA(9), PIK3CD(7), PIK3CG(25), PIK3R1(7), PITX2(4), PPP1R13B(8), PTEN(23), RACGAP1(3), RHO(2), ROCK1(5), ROCK2(13), SAG(9), WASF1(5), WASL(5) 27071500 413 156 387 182 258 32 18 58 46 1 0.00642 1.000 1.000 150 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH6(11), ADH7(13), ADHFE1(6), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AKR1A1(3), AKR1B1(2), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH9A1(3), CEL(13), DGAT1(1), DGKA(4), DGKB(24), DGKD(11), DGKE(7), DGKG(18), DGKH(8), DGKQ(6), DGKZ(8), GK(6), GLA(1), GLB1(8), LCT(43), LIPC(9), LIPF(15), LIPG(6), LPL(3), PNLIP(8), PNLIPRP1(10), PNLIPRP2(3), PPAP2B(9), PPAP2C(8) 18702742 412 151 373 196 295 39 14 41 23 0 0.00411 1.000 1.000 151 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(5), AGT(6), AKT1(3), CALM1(1), CALM2(1), CALR(1), CAMK1(5), CAMK1G(11), CAMK4(12), CREBBP(23), CSNK1A1(3), EDN1(9), ELSPBP1(4), F2(9), FGF2(2), FKBP1A(2), GATA4(3), GSK3B(2), HAND1(2), HAND2(5), HRAS(4), IGF1(11), LIF(2), MAP2K1(13), MAPK1(4), MAPK14(5), MAPK3(1), MAPK8(2), MEF2C(3), MYH2(86), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NKX2-5(2), NPPA(3), PIK3CA(9), PIK3R1(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RAF1(8), RPS6KB1(2), SYT1(20) 19683721 371 151 342 202 258 28 17 37 30 1 0.484 1.000 1.000 152 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(6), ACAA2(2), ACADL(4), ACADM(6), ACADS(4), ACADSB(6), ACADVL(1), ACAT2(1), ACOX1(7), ACOX3(13), ACSL1(6), ACSL3(6), ACSL4(2), ACSL5(23), ACSL6(14), ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(6), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3), CPT1A(11), CPT1B(10), CPT1C(15), CPT2(1), CYP4A11(28), CYP4A22(21), DCI(2), ECHS1(2), EHHADH(7), GCDH(5), HADHA(8), HADHB(4), HSD17B10(2), HSD17B4(6), PECI(3) 19063088 382 150 350 164 278 30 19 30 24 1 0.000954 1.000 1.000 153 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(20), ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(6), ALDH1A3(2), ALDH3A1(7), ALDH3B1(2), ALDH3B2(7), AOC2(8), AOC3(8), AOX1(24), CARM1(6), COMT(3), DBH(14), DCT(3), DDC(12), ECH1(1), ESCO1(2), ESCO2(3), FAH(4), GOT1(6), GOT2(7), HEMK1(5), HGD(12), HPD(5), LCMT1(4), MAOA(4), MAOB(13), METTL2B(8), METTL6(3), MYST3(16), MYST4(16), NAT6(2), PNMT(4), PNPLA3(2), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), SH3GLB1(2), TAT(17), TH(9), TPO(45), TYR(8), TYRP1(8), WBSCR22(1) 23006209 466 149 435 229 341 37 24 41 23 0 0.0235 1.000 1.000 154 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(21), ACSL1(6), ACSL3(6), ACSL4(2), ACSL5(23), ACSL6(14), ADIPOQ(3), ADIPOR1(5), ADIPOR2(2), AGRP(1), AKT1(3), AKT2(8), AKT3(4), CAMKK1(3), CAMKK2(8), CD36(4), CHUK(2), CPT1A(11), CPT1B(10), CPT1C(15), CPT2(1), G6PC(7), G6PC2(7), IKBKB(4), IRS1(6), IRS2(2), IRS4(12), JAK1(6), JAK2(9), JAK3(7), LEP(2), LEPR(25), MAPK10(9), MAPK8(2), MAPK9(7), NFKB1(7), NFKB2(5), NFKBIA(2), NFKBIB(1), NPY(4), PCK1(23), PCK2(4), POMC(3), PPARA(7), PPARGC1A(22), PRKAA1(1), PRKAA2(26), PRKAB1(2), PRKAB2(2), PRKAG1(2), PRKAG2(9), PRKAG3(10), PRKCQ(18), PTPN11(10), RELA(5), RXRA(4), RXRB(4), RXRG(5), SLC2A1(4), SLC2A4(8), SOCS3(2), STAT3(11), STK11(4), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF2(3), TYK2(8) 32153004 480 149 460 267 302 49 23 51 55 0 0.503 1.000 1.000 155 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(12), ACTB(7), ACTG1(5), ARHGEF2(17), ARPC5(1), CD14(5), CDC42(3), CDH1(7), CLDN1(5), CTNNB1(13), CTTN(3), EZR(1), FYN(7), HCLS1(14), ITGB1(4), KRT18(4), LY96(4), NCK1(1), NCK2(6), NCL(6), OCLN(4), PRKCA(11), RHOA(1), ROCK1(5), ROCK2(13), TLR4(34), TLR5(19), TUBA1A(2), TUBA1B(4), TUBA1C(2), TUBA3C(22), TUBA3D(12), TUBA3E(4), TUBA4A(6), TUBA8(3), TUBAL3(13), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(5), TUBB4(4), TUBB4Q(10), TUBB6(10), TUBB8(15), WAS(7), WASL(5), YWHAQ(3) 20306342 346 149 332 135 223 37 12 39 35 0 6.43e-05 1.000 1.000 156 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(12), ACTB(7), ACTG1(5), ARHGEF2(17), ARPC5(1), CD14(5), CDC42(3), CDH1(7), CLDN1(5), CTNNB1(13), CTTN(3), EZR(1), FYN(7), HCLS1(14), ITGB1(4), KRT18(4), LY96(4), NCK1(1), NCK2(6), NCL(6), OCLN(4), PRKCA(11), RHOA(1), ROCK1(5), ROCK2(13), TLR4(34), TLR5(19), TUBA1A(2), TUBA1B(4), TUBA1C(2), TUBA3C(22), TUBA3D(12), TUBA3E(4), TUBA4A(6), TUBA8(3), TUBAL3(13), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(5), TUBB4(4), TUBB4Q(10), TUBB6(10), TUBB8(15), WAS(7), WASL(5), YWHAQ(3) 20306342 346 149 332 135 223 37 12 39 35 0 6.43e-05 1.000 1.000 157 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(8), AGT(6), AGTR1(11), AGTR2(12), CMA1(6), COL4A1(62), COL4A2(33), COL4A3(41), COL4A4(97), COL4A5(56), COL4A6(35), REN(9) 9771968 376 148 351 109 310 19 9 23 15 0 0.414 1.000 1.000 158 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(3), AKT2(8), AKT3(4), BCL2(2), BCR(11), BLNK(14), BTK(17), CD19(7), CD22(26), CD81(2), CR2(33), CSK(1), DAG1(6), FLOT1(2), GRB2(2), GSK3B(2), INPP5D(37), ITPR1(36), ITPR2(18), ITPR3(9), LYN(7), MAP4K1(9), MAPK1(4), MAPK3(1), NFATC1(15), NFATC2(9), NR0B2(6), PDK1(2), PIK3CA(9), PIK3CD(7), PIK3R1(7), PLCG2(25), PPP1R13B(8), PPP3CA(5), PPP3CB(4), PPP3CC(2), PTPRC(33), RAF1(8), SHC1(3), SOS1(9), SOS2(13), SYK(16), VAV1(16) 28607174 458 148 440 206 297 32 27 55 46 1 0.00340 1.000 1.000 159 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(3), AKT2(8), AKT3(4), BRD4(20), CAP1(1), CBL(11), CDC42(3), CDKN2A(34), F2RL2(6), FLOT1(2), GRB2(2), GSK3B(2), IGFBP1(3), INPPL1(15), IRS1(6), IRS2(2), IRS4(12), LNPEP(10), MAPK1(4), MAPK3(1), PARD3(17), PARD6A(2), PDK1(2), PIK3CA(9), PIK3CD(7), PIK3R1(7), PPYR1(12), PTEN(23), PTPN1(4), RAF1(8), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), RPS6KB1(2), SERPINB6(4), SFN(1), SHC1(3), SLC2A4(8), SORBS1(13), SOS1(9), SOS2(13), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3) 23123023 318 148 294 129 150 29 21 51 66 1 0.0930 1.000 1.000 160 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(3), ACP2(2), ACP5(3), ACPP(8), ACPT(1), ALPI(9), ALPL(9), ALPP(11), ALPPL2(12), CYP19A1(12), CYP1A1(10), CYP1A2(12), CYP2A13(12), CYP2A6(12), CYP2A7(8), CYP2B6(16), CYP2C18(26), CYP2C19(42), CYP2C8(31), CYP2C9(38), CYP2D6(2), CYP2E1(13), CYP2F1(11), CYP2J2(7), CYP3A4(20), CYP3A5(10), CYP3A7(21), CYP4B1(21), CYP4F8(15), CYP51A1(1), PON1(15) 11267482 413 147 381 239 322 23 14 23 31 0 0.00897 1.000 1.000 161 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(9), CAD(18), CANT1(9), CDA(2), CTPS(2), CTPS2(3), DCTD(2), DHODH(3), DPYD(61), DPYS(24), ENTPD1(11), ENTPD3(6), ENTPD4(4), ENTPD5(2), ENTPD6(5), ENTPD8(2), NME6(3), NME7(4), NT5C1A(3), NT5C1B(24), NT5C2(3), NT5C3(2), NT5E(4), NT5M(2), PNPT1(2), POLA1(2), POLA2(9), POLD1(6), POLD2(2), POLD3(4), POLE(16), POLE2(3), POLR1A(11), POLR1B(9), POLR1C(1), POLR2A(12), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(5), POLR3B(15), POLR3G(1), POLR3GL(1), POLR3H(2), POLR3K(1), PRIM1(3), PRIM2(15), RRM1(3), RRM2(2), RRM2B(3), TK2(1), TXNRD1(7), TXNRD2(3), TYMS(1), UCK1(2), UMPS(1), UPB1(6), UPP2(5), UPRT(1), ZNRD1(1) 31395481 385 147 364 199 250 33 18 53 31 0 0.301 1.000 1.000 162 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH6(11), ADH7(13), ADHFE1(6), AKR1A1(3), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH9A1(3), ALDOA(2), ALDOB(13), ALDOC(3), BPGM(3), DLAT(2), DLD(2), ENO1(4), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(7), GAPDH(3), GCK(20), GPI(3), HK1(3), HK2(12), HK3(15), LDHA(6), LDHB(2), LDHC(5), PDHA1(3), PDHA2(19), PDHB(1), PFKM(2), PGK1(5), PGM1(4), PGM3(4), PKLR(11), PKM2(5) 18926673 343 146 311 152 240 33 15 31 24 0 0.000141 1.000 1.000 163 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH6(11), ADH7(13), ADHFE1(6), AKR1A1(3), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH9A1(3), ALDOA(2), ALDOB(13), ALDOC(3), BPGM(3), DLAT(2), DLD(2), ENO1(4), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(7), GAPDH(3), GCK(20), GPI(3), HK1(3), HK2(12), HK3(15), LDHA(6), LDHB(2), LDHC(5), PDHA1(3), PDHA2(19), PDHB(1), PFKM(2), PGK1(5), PGM1(4), PGM3(4), PKLR(11), PKM2(5) 18926673 343 146 311 152 240 33 15 31 24 0 0.000141 1.000 1.000 164 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(1), APH1A(2), CREBBP(23), CTBP2(1), DLL1(4), DLL3(7), DLL4(7), DTX1(9), DTX2(3), DTX3(6), DTX3L(6), DTX4(4), DVL2(3), DVL3(7), EP300(14), HDAC1(1), HDAC2(1), HES1(2), JAG1(10), JAG2(8), LFNG(3), MAML1(4), MAML2(6), MAML3(9), MFNG(8), NCOR2(26), NCSTN(4), NOTCH1(5), NOTCH2(41), NOTCH3(23), NOTCH4(57), NUMB(6), NUMBL(5), PSEN1(1), PSEN2(2), PSENEN(1), PTCRA(3), RBPJ(4), RBPJL(3), SNW1(2) 26602352 332 146 326 173 198 32 11 66 25 0 0.726 1.000 1.000 165 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(5), AKT1(3), BDKRB2(10), CALM1(1), CALM2(1), CAV1(2), CHRM1(5), CHRNA1(5), FLT1(33), FLT4(27), KDR(45), NOS3(17), PDE2A(14), PDE3A(27), PDE3B(6), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKG1(13), PRKG2(16), RYR2(90), SLC7A1(3), SYT1(20), TNNI1(2) 15769998 368 146 347 212 261 27 11 33 35 1 0.298 1.000 1.000 166 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(5), ALAS1(1), ALAS2(5), BLVRA(3), BLVRB(1), COX10(6), COX15(4), CP(12), CPOX(4), EPRS(11), FECH(3), FTH1(3), FTMT(8), GUSB(4), HCCS(2), HMBS(2), HMOX1(1), HMOX2(2), MMAB(2), PPOX(3), UGT1A1(5), UGT1A10(15), UGT1A3(12), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(12), UGT1A8(7), UGT1A9(11), UGT2A1(22), UGT2A3(24), UGT2B10(38), UGT2B11(22), UGT2B15(29), UGT2B28(26), UGT2B4(36), UGT2B7(21), UROS(1) 16309776 387 145 358 149 269 33 19 23 42 1 8.07e-05 1.000 1.000 167 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(3), ATF2(5), CDC42(3), DLD(2), DUSP10(6), DUSP4(3), DUSP8(4), GAB1(4), GCK(20), IL1R1(12), JUN(1), MAP2K4(4), MAP2K5(3), MAP2K7(4), MAP3K1(3), MAP3K10(8), MAP3K11(6), MAP3K12(4), MAP3K13(10), MAP3K2(6), MAP3K3(6), MAP3K4(16), MAP3K5(18), MAP3K7(1), MAP3K9(24), MAPK10(9), MAPK7(4), MAPK8(2), MAPK9(7), MYEF2(4), NFATC3(9), NR2C2(2), PAPPA(59), SHC1(3), TP53(43), TRAF6(5), ZAK(7) 19476697 330 145 309 125 216 30 12 33 38 1 0.0158 1.000 1.000 168 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(6), BMP4(3), BMP5(27), BMP6(11), BMP7(2), BMP8A(2), BMP8B(2), BTRC(5), CSNK1A1(3), CSNK1A1L(6), CSNK1D(1), CSNK1E(4), CSNK1G1(4), CSNK1G2(2), CSNK1G3(3), DHH(1), FBXW11(5), GLI1(16), GLI2(38), GLI3(17), GSK3B(2), HHIP(22), IHH(4), LRP2(94), PRKACA(4), PRKACB(4), PRKACG(8), PRKX(4), PTCH1(10), PTCH2(18), RAB23(1), SHH(5), SMO(11), STK36(14), SUFU(3), WNT1(2), WNT10A(7), WNT10B(5), WNT11(4), WNT16(1), WNT2(7), WNT2B(5), WNT3(6), WNT3A(6), WNT4(2), WNT5A(5), WNT5B(5), WNT6(2), WNT7A(14), WNT7B(6), WNT8A(7), WNT8B(7), WNT9A(3), WNT9B(3), ZIC2(2) 23334315 461 144 437 219 319 38 22 45 37 0 0.0114 1.000 1.000 169 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(22), AXIN1(11), CCND1(1), CCND2(5), CCND3(2), CSNK1E(4), CTNNB1(13), DVL2(3), DVL3(7), FBXW2(2), FZD1(4), FZD10(2), FZD2(5), FZD5(2), FZD6(2), FZD7(4), FZD8(6), FZD9(1), GSK3B(2), JUN(1), LDLR(16), MAPK10(9), MAPK9(7), MYC(5), PAFAH1B1(4), PLAU(3), PPP2R5C(5), PPP2R5E(4), PRKCA(11), PRKCD(4), PRKCE(6), PRKCG(14), PRKCH(11), PRKCI(8), PRKCQ(18), PRKCZ(6), PRKD1(3), RAC1(17), RHOA(1), SFRP4(6), TCF7(2), WNT1(2), WNT10A(7), WNT10B(5), WNT11(4), WNT16(1), WNT2(7), WNT2B(5), WNT3(6), WNT4(2), WNT5A(5), WNT5B(5), WNT6(2), WNT7A(14), WNT7B(6) 23085615 330 144 314 178 213 31 11 38 37 0 0.251 1.000 1.000 170 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(6), CALR(1), CANX(1), CD4(6), CD74(6), CD8A(2), CD8B(8), CIITA(17), CTSB(2), CTSL1(2), CTSS(7), HLA-A(3), HLA-B(5), HLA-C(1), HLA-DMA(4), HLA-DMB(7), HLA-DOA(5), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(7), HLA-DQB1(5), HLA-DRA(11), HLA-DRB1(4), HLA-DRB5(1), HLA-E(1), HLA-F(6), HLA-G(4), HSP90AA1(3), HSP90AB1(6), HSPA5(5), IFI30(2), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(10), IFNA17(2), IFNA2(1), IFNA21(9), IFNA4(1), IFNA5(3), IFNA6(3), IFNA7(5), IFNA8(3), KIR2DL1(21), KIR2DL3(6), KIR2DL4(4), KIR2DS4(16), KIR3DL1(18), KIR3DL2(2), KIR3DL3(9), KLRC1(5), KLRC2(1), KLRC3(11), KLRC4(5), KLRD1(5), LGMN(6), LTA(2), NFYA(2), NFYB(3), NFYC(2), PDIA3(4), PSME2(4), RFX5(5), RFXANK(1), RFXAP(1), TAP1(2), TAP2(13), TAPBP(2) 17815488 345 142 334 184 228 34 14 39 30 0 0.143 1.000 1.000 171 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(6), BAX(3), BCL2(2), BCL2L11(5), BIRC2(5), BIRC3(8), BIRC5(1), BNIP3L(2), CASP1(5), CASP10(5), CASP2(1), CASP3(2), CASP4(1), CASP7(5), CASP8(9), CASP9(3), CHUK(2), CYCS(1), DFFA(2), DFFB(3), FAS(5), FASLG(14), GZMB(3), HELLS(5), IKBKB(4), IRF1(1), IRF2(5), IRF3(4), IRF4(3), IRF5(5), IRF6(16), IRF7(7), JUN(1), LTA(2), MAP2K4(4), MAP3K1(3), MAPK10(9), MDM2(4), MYC(5), NFKB1(7), NFKBIA(2), NFKBIB(1), PLEKHG5(13), PRF1(13), RELA(5), RIPK1(1), TNF(1), TNFRSF10B(3), TNFRSF1A(3), TNFRSF1B(3), TNFRSF21(10), TNFRSF25(5), TNFSF10(8), TP53(43), TP73(5), TRAF1(6), TRAF2(3), TRAF3(5) 22141310 308 140 295 144 197 30 17 29 35 0 0.110 1.000 1.000 172 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(3), AKT2(8), AKT3(4), BCR(11), BLNK(14), BTK(17), CD19(7), CSK(1), DAG1(6), EPHB2(31), GRB2(2), ITPKA(1), ITPKB(6), LYN(7), MAP2K1(13), MAP2K2(4), MAPK1(4), NFAT5(8), NFKB1(7), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PI3(6), PIK3CA(9), PIK3CD(7), PIK3R1(7), PLCG2(25), PPP1R13B(8), RAF1(8), SERPINA4(16), SHC1(3), SOS1(9), SOS2(13), SYK(16), VAV1(16) 20456119 312 140 296 160 195 22 17 45 32 1 0.305 1.000 1.000 173 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(10), F11(15), F12(1), F13B(24), F2(9), F5(37), F7(9), F8(46), F9(12), FGA(42), FGB(10), FGG(8), LPA(53), PLAT(4), PLAU(3), PLG(33), SERPINB2(19), SERPINE1(5), SERPINF2(8), VWF(51) 13601051 399 139 375 164 282 30 23 29 34 1 0.0128 1.000 1.000 174 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), GUSB(4), UGDH(1), UGP2(2), UGT1A1(5), UGT1A10(15), UGT1A3(12), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(12), UGT1A8(7), UGT1A9(11), UGT2A1(22), UGT2A3(24), UGT2B10(38), UGT2B11(22), UGT2B15(29), UGT2B28(26), UGT2B4(36), UGT2B7(21), XYLB(5) 10526835 318 139 290 127 225 26 15 18 33 1 0.000904 1.000 1.000 175 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(12), ALOX12(5), ALOX12B(13), ALOX15(9), ALOX15B(10), ALOX5(9), CBR3(1), CYP2B6(16), CYP2C18(26), CYP2C19(42), CYP2C8(31), CYP2C9(38), CYP2E1(13), CYP2J2(7), CYP2U1(1), CYP4A11(28), CYP4A22(21), CYP4F2(12), CYP4F3(20), EPHX2(4), GGT1(7), GPX1(3), GPX3(3), GPX5(13), GPX6(16), LTA4H(4), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(7), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), PTGDS(2), PTGES2(2), PTGIS(12), PTGS1(17), PTGS2(11), TBXAS1(14) 14972790 486 139 454 317 388 28 6 29 34 1 0.252 1.000 1.000 176 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(11), CD28(1), CD3D(5), CSK(1), CTLA4(2), DAG1(6), EPHB2(31), FBXW7(12), GRAP2(5), GRB2(2), ITK(21), ITPKA(1), ITPKB(6), LAT(1), LCK(14), LCP2(10), MAPK1(4), NCK1(1), NFAT5(8), NFKB1(7), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PAK7(48), PLCG1(9), PTPRC(33), RAF1(8), RASGRP1(9), RASGRP2(7), RASGRP3(15), RASGRP4(11), SOS1(9), SOS2(13), VAV1(16), ZAP70(7) 21463893 380 139 363 181 238 30 19 52 41 0 0.142 1.000 1.000 177 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(62), COL4A2(33), COL4A3(41), COL4A4(97), COL4A5(56), COL4A6(35), P4HB(3), SLC23A1(5), SLC23A2(4), SLC2A1(4), SLC2A3(8) 9660609 348 139 326 92 287 17 10 21 13 0 0.0689 1.000 1.000 178 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(2), INPP1(2), INPP4A(6), INPP4B(4), INPP5A(4), INPPL1(15), ITPKA(1), ITPKB(6), MIOX(3), OCRL(5), PIK3C2A(8), PIK3C2B(14), PIK3C2G(50), PIK3CA(9), PIK3CB(26), PIK3CG(25), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), PLCD1(4), PLCG1(9), PLCG2(25) 17271843 359 138 326 156 242 17 17 46 36 1 0.00631 1.000 1.000 179 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(5), ACTG2(5), ACTR2(3), ACTR3(2), AKT1(3), ANGPTL2(3), CDC42(3), CFL1(1), FLNA(15), FLNC(60), FSCN1(4), FSCN2(2), FSCN3(10), GDI1(1), GDI2(2), LIMK1(4), MYH2(86), MYLK(41), MYLK2(13), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PAK7(48), RHO(2), ROCK1(5), ROCK2(13), VASP(3), WASF1(5), WASL(5) 18472972 375 138 345 206 261 46 9 36 23 0 0.0688 1.000 1.000 180 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(1), CALM2(1), CAMK1(5), CAMK1G(11), ELK1(2), FPR1(20), GNA15(5), HRAS(4), MAP2K1(13), MAP2K2(4), MAP2K3(9), MAP2K6(3), MAP3K1(3), MAPK1(4), MAPK14(5), MAPK3(1), NCF1(1), NCF2(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB1(7), NFKBIA(2), PAK1(4), PIK3C2G(50), PLCB1(52), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAC1(17), RAF1(8), RELA(5), SYT1(20) 14743132 321 137 283 134 229 17 12 32 31 0 0.0120 1.000 1.000 181 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(5), AKT1(3), APC(22), CAMP(1), DAG1(6), DLG4(6), EPHB2(31), GNAI1(1), GNAQ(5), ITPR1(36), ITPR2(18), ITPR3(9), KCNJ3(22), KCNJ5(15), KCNJ9(4), MAPK1(4), PITX2(4), PTX3(1), RAC1(17), RHO(2), RYR1(93) 17637343 305 137 286 187 214 26 13 27 25 0 0.326 1.000 1.000 182 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(5), C1QB(5), C1R(14), C1S(20), C2(16), C3(49), C5(16), C6(66), C7(52), C8A(40), C8B(48), C9(22), MASP1(9) 7985113 362 136 318 141 277 19 10 31 24 1 0.000104 1.000 1.000 183 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(7), ADAM17(1), ATP6AP1(2), ATP6V0A1(9), ATP6V0A2(5), ATP6V0A4(20), ATP6V0D2(8), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C2(9), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), CASP3(2), CDC42(3), CHUK(2), CSK(1), EGFR(23), F11R(5), GIT1(4), HBEGF(1), IGSF5(11), IKBKB(4), IL8(1), JAM2(10), JAM3(2), JUN(1), LYN(7), MAP2K4(4), MAP3K14(4), MAPK10(9), MAPK11(1), MAPK12(2), MAPK13(5), MAPK14(5), MAPK8(2), MAPK9(7), MET(23), NFKB1(7), NFKB2(5), NFKBIA(2), NOD1(6), PAK1(4), PLCG1(9), PLCG2(25), PTPN11(10), PTPRZ1(24), RAC1(17), RELA(5), SRC(1), TCIRG1(3), TJP1(11) 27275166 359 136 345 207 226 32 18 54 29 0 0.768 1.000 1.000 184 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(5), AANAT(1), ABP1(20), ACAT2(1), ACMSD(10), AFMID(3), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3), AOC2(8), AOC3(8), AOX1(24), ASMT(7), CARM1(6), CAT(6), CYP1A1(10), CYP1A2(12), CYP1B1(2), DDC(12), ECHS1(2), EHHADH(7), GCDH(5), HAAO(3), HADHA(8), HEMK1(5), HSD17B10(2), HSD17B4(6), INMT(10), KMO(8), KYNU(11), LCMT1(4), LNX1(19), MAOA(4), MAOB(13), METTL2B(8), METTL6(3), NFX1(7), OGDH(11), OGDHL(41), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), TDO2(5), TPH1(9), TPH2(16), WARS(4), WARS2(4), WBSCR22(1) 23433597 412 135 394 207 289 33 19 46 25 0 0.0449 1.000 1.000 185 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(5), CRK(3), CRKL(2), DOCK1(15), ELK1(2), FOS(2), GAB1(4), GRB2(2), HGF(24), HRAS(4), ITGA1(18), ITGB1(4), JUN(1), MAP2K1(13), MAP2K2(4), MAP4K1(9), MAPK1(4), MAPK3(1), MAPK8(2), MET(23), PAK1(4), PIK3CA(9), PIK3R1(7), PTEN(23), PTK2(8), PTK2B(11), PTPN11(10), PXN(3), RAF1(8), RAP1A(2), RAP1B(1), RASA1(4), SOS1(9), SRC(1), STAT3(11) 16920544 253 133 235 106 142 18 12 41 39 1 0.315 1.000 1.000 186 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(5), C1QB(5), C1R(14), C1S(20), C2(16), C3(49), C5(16), C6(66), C7(52), C8A(40), C9(22), MASP1(9), MASP2(9), MBL2(13) 8183744 336 132 296 131 258 17 6 29 25 1 0.000183 1.000 1.000 187 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(20), ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH6(11), ADH7(13), ADHFE1(6), ALDH1A3(2), ALDH3A1(7), ALDH3B1(2), ALDH3B2(7), AOC2(8), AOC3(8), AOX1(24), COMT(3), DBH(14), DCT(3), DDC(12), FAH(4), GOT1(6), GOT2(7), HGD(12), HPD(5), MAOA(4), MAOB(13), PNMT(4), TAT(17), TH(9), TPO(45), TYR(8) 12238967 360 132 331 173 279 26 17 21 17 0 0.000844 1.000 1.000 188 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(13), BMPR1B(4), CCND2(5), CDK4(5), CDKN1B(1), DAZL(4), DMC1(10), EGR1(4), ESR2(8), FSHR(19), GJA4(4), INHA(4), LHCGR(27), MLH1(6), MSH5(16), NCOR1(20), NR5A1(7), NRIP1(9), PGR(15), PRLR(30), PTGER2(6), SMPD1(3), VDR(3), ZP2(14) 13514812 237 131 216 119 160 16 7 27 27 0 0.514 1.000 1.000 189 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(49), B3GALT4(2), CDR1(15), DGKI(26), IL6ST(10), MRPL19(1), PIGK(6), RPL10(4), RPL11(2), RPL13A(2), RPL14(1), RPL15(2), RPL18(3), RPL18A(1), RPL19(1), RPL21(1), RPL22(2), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL38(1), RPL39(1), RPL3L(3), RPL4(5), RPL5(6), RPL6(1), RPL7(2), RPL7A(1), RPLP0(1), RPLP2(1), RPS10(1), RPS11(1), RPS13(1), RPS15(1), RPS16(1), RPS18(1), RPS2(2), RPS20(2), RPS23(1), RPS24(1), RPS27(1), RPS27A(2), RPS29(1), RPS3A(1), RPS4Y1(1), RPS5(2), RPS6(1), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), RPS6KA6(16), RPS6KB1(2), RPS6KB2(3), RPS7(4), RPS8(1), RPSA(2), SLC36A2(8), TBC1D10C(5), TSPAN9(4), UBB(1), UBC(6) 20113629 253 131 242 147 157 24 15 34 23 0 0.736 1.000 1.000 190 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(20), AGMAT(3), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH4A1(6), ALDH9A1(3), AOC2(8), AOC3(8), ARG1(2), ARG2(1), ASL(6), CKM(2), CKMT1A(1), CKMT2(5), CPS1(22), DAO(10), GAMT(4), GATM(5), GLUD1(2), GOT1(6), GOT2(7), MAOA(4), MAOB(13), NOS1(65), NOS3(17), OAT(3), ODC1(3), OTC(3), P4HA1(9), P4HA2(5), P4HA3(13), P4HB(3), PYCR1(2), RARS(7), SMS(6) 17055310 315 130 301 177 209 37 16 23 30 0 0.214 1.000 1.000 191 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(6), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPAT6(3), CDS1(11), CDS2(4), CHAT(15), CHKA(2), CHKB(3), CHPT1(1), CRLS1(1), DGKA(4), DGKB(24), DGKD(11), DGKE(7), DGKG(18), DGKH(8), DGKI(26), DGKQ(6), DGKZ(8), ESCO1(2), ESCO2(3), ETNK1(4), GNPAT(2), GPAM(5), GPD1(9), GPD1L(3), GPD2(2), LYPLA1(1), LYPLA2(1), MYST3(16), MYST4(16), NAT6(2), PCYT1A(3), PCYT1B(8), PEMT(2), PISD(2), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(7), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), PLD1(12), PLD2(7), PNPLA3(2), PPAP2B(9), PPAP2C(8), PTDSS2(2), SH3GLB1(2) 25297408 363 130 343 203 234 32 13 48 36 0 0.632 1.000 1.000 192 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(2), AKT1(3), AKT2(8), AKT3(4), BTK(17), CDKN2A(34), DAPP1(6), GRB2(2), GSK3B(2), IARS(8), IGFBP1(3), INPP5D(37), PDK1(2), PIK3CA(9), PPP1R13B(8), PTEN(23), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(3), SOS1(9), SOS2(13), TEC(10), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3) 13963791 231 130 201 65 121 13 19 27 51 0 0.000286 1.000 1.000 193 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(6), ACAA2(2), ACAD8(1), ACAD9(1), ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(6), AKR1B10(8), AKR1C4(9), AKR1D1(20), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3), BAAT(12), CEL(13), CYP27A1(4), CYP7A1(9), HADHB(4), HSD3B7(3), LIPA(4), RDH11(2), RDH12(2), RDH13(3), SLC27A5(7), SOAT1(3), SOAT2(6), SRD5A1(3), SRD5A2(7) 12310868 285 129 255 128 190 31 20 26 18 0 0.00299 1.000 1.000 194 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(9), ABP1(20), ACADL(4), ACADM(6), ACADSB(6), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH9A1(3), AOC2(8), AOC3(8), CNDP1(9), DPYD(61), DPYS(24), ECHS1(2), EHHADH(7), GAD1(15), GAD2(10), HADHA(8), MLYCD(3), SDS(2), SMS(6), UPB1(6) 11270832 258 128 242 121 172 23 12 32 19 0 0.0542 1.000 1.000 195 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(17), CALM1(1), CALM2(1), ELK1(2), FCER1A(14), FCER1G(1), FOS(2), GRB2(2), HRAS(4), JUN(1), LYN(7), MAP2K1(13), MAP2K4(4), MAP2K7(4), MAP3K1(3), MAPK1(4), MAPK3(1), MAPK8(2), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PAK2(8), PIK3CA(9), PIK3R1(7), PLA2G4A(11), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAF1(8), SHC1(3), SOS1(9), SYK(16), SYT1(20), VAV1(16) 16626713 256 128 240 117 165 13 14 38 25 1 0.361 1.000 1.000 196 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(9), AKR1D1(20), ARSB(1), ARSD(3), ARSE(5), CYP11B1(16), CYP11B2(14), HSD11B1(11), HSD11B2(2), HSD17B2(10), HSD17B3(6), HSD3B1(10), HSD3B2(11), SRD5A1(3), SRD5A2(7), STS(7), SULT1E1(16), SULT2A1(8), UGT1A1(5), UGT1A10(15), UGT1A3(12), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(12), UGT1A8(7), UGT1A9(11), UGT2B15(29), UGT2B4(36) 10551243 310 127 284 139 212 32 17 19 29 1 0.000973 1.000 1.000 197 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(6), AGTR2(12), CALM1(1), CALM2(1), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CDK5(4), F2(9), FYN(7), GNA11(7), GNAI1(1), GRB2(2), HRAS(4), JAK2(9), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK14(5), MAPK3(1), MAPK8(2), MAPT(12), MYLK(41), PLCG1(9), PRKCA(11), PTK2B(11), RAF1(8), SHC1(3), SOS1(9), STAT1(4), STAT3(11), STAT5A(3), SYT1(20) 16061825 256 127 233 147 164 22 12 35 23 0 0.652 1.000 1.000 198 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(8), B4GALT1(2), B4GALT2(2), G6PC(7), G6PC2(7), GAA(7), GALE(1), GALK1(1), GALK2(3), GALT(2), GANC(6), GCK(20), GLA(1), GLB1(8), HK1(3), HK2(12), HK3(15), HSD3B7(3), LALBA(7), LCT(43), MGAM(142), PFKL(4), PFKM(2), PGM1(4), PGM3(4), RDH11(2), RDH12(2), RDH13(3), UGP2(2) 14921618 325 127 305 178 236 29 7 30 23 0 0.0550 1.000 1.000 199 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(49), C5(16), C6(66), C7(52), ICAM1(3), IL1A(4), IL6(2), IL8(1), ITGA4(38), ITGAL(24), ITGB1(4), ITGB2(14), SELP(31), SELPLG(8), TNF(1), VCAM1(18) 9542594 331 127 297 134 243 11 16 27 33 1 0.000409 1.000 1.000 200 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(18), CANT1(9), CDA(2), CTPS(2), CTPS2(3), DCTD(2), DHODH(3), DPYD(61), DPYS(24), ENTPD1(11), NT5E(4), NT5M(2), POLD1(6), POLD2(2), POLE(16), POLG(9), POLL(7), POLQ(25), POLR1B(9), POLR2A(12), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(2), RRM1(3), RRM2(2), TK2(1), TXNRD1(7), TYMS(1), UCK1(2), UMPS(1), UNG(3), UPB1(6) 22225332 276 127 257 126 176 24 12 39 25 0 0.0510 1.000 1.000 201 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(5), C1QB(5), C1R(14), C1S(20), C2(16), C3(49), C5(16), C6(66), C7(52), C8A(40), C9(22) 6707371 305 126 267 116 233 14 6 28 23 1 0.000273 1.000 1.000 202 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(2), ALDOB(13), ALDOC(3), DLAT(2), DLD(2), ENO1(4), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(7), GAPDH(3), GAPDHS(1), GCK(20), GOT1(6), GOT2(7), GPI(3), HK1(3), HK2(12), HK3(15), LDHA(6), LDHAL6B(7), LDHB(2), LDHC(5), MDH1(1), MDH2(4), PC(13), PCK1(23), PDHA1(3), PDHA2(19), PDHB(1), PDHX(2), PFKL(4), PFKM(2), PGAM2(3), PGK1(5), PGK2(29), PKLR(11), PKM2(5), TNFAIP1(1) 16478667 261 126 243 129 187 21 12 21 20 0 0.00313 1.000 1.000 203 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(8), ALOX15(9), ALOX5(9), CYP1A2(12), CYP2C18(26), CYP2C19(42), CYP2C8(31), CYP2C9(38), CYP2E1(13), CYP2J2(7), CYP3A4(20), CYP3A43(16), CYP3A5(10), CYP3A7(21), HSD3B7(3), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(7), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), RDH11(2), RDH12(2), RDH13(3) 9247613 336 126 312 195 264 14 9 19 30 0 0.0826 1.000 1.000 204 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM2(1), DLG4(6), GRIN1(7), GRIN2A(91), GRIN2B(56), GRIN2C(8), GRIN2D(6), NOS1(65), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(11), SYT1(20) 9860712 306 126 283 194 228 29 6 20 23 0 0.338 1.000 1.000 205 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(1), CALM2(1), CD3D(5), CD3E(2), CD3G(1), ELK1(2), FOS(2), FYN(7), GRB2(2), HRAS(4), JUN(1), LAT(1), LCK(14), MAP2K1(13), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(2), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB1(7), NFKBIA(2), PIK3CA(9), PIK3R1(7), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(11), PTPN7(3), RAC1(17), RAF1(8), RASA1(4), RELA(5), SHC1(3), SOS1(9), SYT1(20), VAV1(16), ZAP70(7) 18478450 260 125 236 111 170 21 11 34 23 1 0.136 1.000 1.000 206 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(6), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPS(5), CDS1(11), CDS2(4), CHAT(15), CHKA(2), CHKB(3), CLC(3), CPT1B(10), DGKA(4), DGKB(24), DGKD(11), DGKE(7), DGKG(18), DGKH(8), DGKQ(6), DGKZ(8), ETNK1(4), GNPAT(2), GPD1(9), GPD2(2), LGALS13(4), LYPLA1(1), LYPLA2(1), PAFAH1B1(4), PAFAH2(2), PCYT1A(3), PCYT1B(8), PEMT(2), PISD(2), PLA2G1B(1), PLA2G2A(2), PLA2G2E(4), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), PLCB2(10), PLCG1(9), PLCG2(25), PPAP2B(9), PPAP2C(8) 19344460 318 124 304 170 221 22 9 40 26 0 0.113 1.000 1.000 207 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(9), ABP1(20), ACADM(6), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3), AOC2(8), AOC3(8), CNDP1(9), DPYD(61), DPYS(24), ECHS1(2), EHHADH(7), GAD1(15), GAD2(10), HADHA(8), HIBCH(1), MLYCD(3), SMS(6), UPB1(6) 10482633 240 124 223 116 158 22 13 31 16 0 0.0952 1.000 1.000 208 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B4GALT5(3), C1GALT1(6), C1GALT1C1(2), GALNT1(4), GALNT10(6), GALNT11(3), GALNT12(9), GALNT13(29), GALNT14(27), GALNT2(6), GALNT3(3), GALNT4(6), GALNT5(9), GALNT6(17), GALNT7(5), GALNT8(24), GALNT9(5), GALNTL1(5), GALNTL2(23), GALNTL4(6), GALNTL5(14), GCNT1(7), GCNT3(7), GCNT4(4), OGT(10), ST3GAL1(6), ST3GAL2(1), ST6GALNAC1(5), WBSCR17(39) 12513867 291 124 272 144 217 15 8 24 27 0 0.170 1.000 1.000 209 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(6), ACAA2(2), ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH6(11), ADH7(13), ADHFE1(6), AKR1C4(9), AKR1D1(20), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH9A1(3), BAAT(12), CEL(13), CYP27A1(4), CYP7A1(9), HADHB(4), SOAT2(6), SRD5A1(3), SRD5A2(7) 9042360 255 123 228 104 172 26 15 24 18 0 0.000606 1.000 1.000 210 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(2), B4GALT2(2), FBP2(2), G6PC(7), GAA(7), GALE(1), GALK1(1), GALK2(3), GALT(2), GANAB(5), GCK(20), GLA(1), GLB1(8), HK1(3), HK2(12), HK3(15), LALBA(7), LCT(43), MGAM(142), PFKM(2), PGM1(4), PGM3(4) 12582356 295 123 275 158 216 29 7 26 17 0 0.0421 1.000 1.000 211 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(3), ACTR3(2), AKT1(3), ANGPTL2(3), DAG1(6), DGKA(4), ETFA(2), GCA(3), ITGA9(14), ITPKA(1), ITPKB(6), ITPR1(36), ITPR2(18), ITPR3(9), MAP2K1(13), MAPK1(4), MAPK3(1), NR1I3(7), PAK1(4), PDE3A(27), PDE3B(6), PI3(6), PIK3C2G(50), PIK3CA(9), PIK3CD(7), PIK3R1(7), RIPK3(11), VASP(3) 18783309 265 123 243 97 177 21 13 28 25 1 3.91e-05 1.000 1.000 212 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(3), AKT2(8), AKT3(4), ARHGEF11(19), BCL2(2), CDC42(3), DLG4(6), GNA13(1), LPA(53), MAP2K4(4), MAP3K1(3), MAP3K5(18), MAPK8(2), NFKB1(7), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PDK1(2), PHKA2(7), PI3(6), PIK3CB(26), PLD1(12), PLD2(7), PLD3(1), PTK2(8), RDX(1), ROCK1(5), ROCK2(13), SERPINA4(16), SRF(2), TBXA2R(4) 18989559 258 123 244 131 143 20 11 51 33 0 0.632 1.000 1.000 213 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(12), ATM(13), ATR(25), CCNA1(18), CCND1(1), CCNE1(4), CDC25A(8), CDK4(5), CDK6(3), CDKN1A(4), CDKN1B(1), CDKN2A(34), E2F1(7), GSK3B(2), HDAC1(1), RB1(8), SKP2(2), TFDP1(3), TGFB1(1), TGFB2(1), TGFB3(3), TP53(43) 11702750 199 122 169 48 97 8 14 25 53 2 1.51e-05 1.000 1.000 214 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(60), GABBR1(8), GPRC5A(4), GPRC5B(5), GPRC5C(8), GPRC5D(3), GRM1(17), GRM2(9), GRM3(54), GRM4(20), GRM5(15), GRM7(39), GRM8(50) 8096426 292 121 271 199 208 21 16 25 22 0 0.163 1.000 1.000 215 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(7), APOA1(2), CD36(4), CPT1B(10), CREBBP(23), EHHADH(7), EP300(14), FABP1(7), HSD17B4(6), JUN(1), LPL(3), MAPK1(4), MAPK3(1), ME1(20), MYC(5), NCOA1(10), NCOR1(20), NCOR2(26), NFKBIA(2), NR0B2(6), NR1H3(3), NR2F1(8), NRIP1(9), PDGFA(1), PIK3CA(9), PIK3R1(7), PPARA(7), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(11), PTGS2(11), RB1(8), RELA(5), RXRA(4), SP1(5), STAT5A(3), STAT5B(4), TNF(1) 24567258 297 121 288 140 189 20 19 37 29 3 0.277 1.000 1.000 216 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(5), AASDHPPT(3), AASS(4), ACAT2(1), AKR1B10(8), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3), BBOX1(5), DOT1L(11), ECHS1(2), EHHADH(7), EHMT1(8), EHMT2(9), GCDH(5), HADHA(8), HSD17B10(2), HSD17B4(6), HSD3B7(3), NSD1(17), OGDH(11), OGDHL(41), PIPOX(5), PLOD1(5), PLOD2(7), PLOD3(5), RDH11(2), RDH12(2), RDH13(3), SETD1A(24), SETD7(3), SETDB1(10), SHMT1(1), SHMT2(3), SUV39H1(1), SUV39H2(2), TMLHE(2) 22413042 268 119 259 126 175 27 14 35 17 0 0.0871 1.000 1.000 217 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(7), AADAC(16), ABAT(9), ACADS(4), ACAT2(1), ACSM1(27), AKR1B10(8), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH5A1(11), ALDH7A1(10), ALDH9A1(3), BDH1(5), DDHD1(7), ECHS1(2), EHHADH(7), GAD1(15), GAD2(10), HADHA(8), HMGCL(4), HMGCS1(2), HMGCS2(18), HSD17B10(2), HSD17B4(6), HSD3B7(3), ILVBL(4), L2HGDH(3), OXCT1(5), OXCT2(4), PDHA1(3), PDHA2(19), PDHB(1), PLA1A(9), PPME1(1), PRDX6(4), RDH11(2), RDH12(2), RDH13(3) 15757736 269 119 257 135 183 26 13 27 20 0 0.110 1.000 1.000 218 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(11), CFL1(1), GNAQ(5), GNAS(22), HRAS(4), LIMK1(4), MAP2K1(13), MAPK1(4), MAPK3(1), MYL2(5), NOX1(11), PIK3C2G(50), PLCB1(52), PPP1R12B(8), PRKCA(11), PTK2(8), RAF1(8), ROCK2(13) 9699960 232 118 208 91 164 9 7 33 19 0 0.0269 1.000 1.000 219 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(2), CHUK(2), DAXX(10), EGF(19), EGFR(23), ETS1(5), ETS2(9), FOS(2), HOXA7(2), HRAS(4), IKBKB(4), JUN(1), MAP2K1(13), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(4), MAP3K1(3), MAP3K14(4), MAP3K5(18), MAPK1(4), MAPK13(5), MAPK14(5), MAPK3(1), MAPK8(2), NFKB1(7), NFKBIA(2), PPP2CA(1), PRKCA(11), PRKCD(4), PRKCE(6), PRKCG(14), PRKCH(11), PRKCQ(18), RAF1(8), RELA(5), RIPK1(1), SP1(5), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF2(3) 18955484 261 118 248 156 164 24 12 37 24 0 0.863 1.000 1.000 220 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(5), BCR(11), BLNK(14), ELK1(2), FOS(2), GRB2(2), HRAS(4), JUN(1), LYN(7), MAP2K1(13), MAP3K1(3), MAPK1(4), MAPK3(1), MAPK8IP3(9), PAPPA(59), RAC1(17), RPS6KA1(9), RPS6KA3(2), SHC1(3), SOS1(9), SYK(16), VAV1(16), VAV2(4), VAV3(10) 12330944 223 118 195 115 163 15 5 22 17 1 0.286 1.000 1.000 221 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(3), AKT2(8), AKT3(4), ANKRD6(3), APC(22), AXIN1(11), AXIN2(4), CER1(13), CSNK1A1(3), CTNNB1(13), DACT1(11), DKK1(2), DKK2(17), DKK3(4), DKK4(3), FSTL1(2), GSK3B(2), LRP1(40), MVP(11), NKD1(8), NKD2(6), PIN1(1), PSEN1(1), PTPRA(7), SENP2(12), SFRP1(2), TSHB(7), WIF1(8) 15482607 228 117 221 115 131 26 13 33 25 0 0.434 1.000 1.000 222 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(21), ACACB(21), ACAT2(1), ACOT12(12), ACSS1(1), ACSS2(4), AKR1B1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(2), LDHA(6), LDHAL6A(5), LDHAL6B(7), LDHB(2), LDHC(5), LDHD(3), MDH1(1), MDH2(4), ME1(20), ME2(1), ME3(11), PC(13), PCK1(23), PCK2(4), PDHA1(3), PDHA2(19), PDHB(1), PKLR(11), PKM2(5) 18157333 252 116 242 130 163 21 15 35 18 0 0.182 1.000 1.000 223 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(10), ADRA1B(4), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(2), CHRM1(5), CHRM2(19), CHRM3(22), CHRM4(6), CHRM5(4), DRD1(11), DRD2(17), DRD3(6), DRD4(1), DRD5(23), HRH1(18), HRH2(4), HTR1A(8), HTR1B(1), HTR1D(3), HTR1E(6), HTR1F(8), HTR2A(9), HTR2B(2), HTR2C(12), HTR4(10), HTR5A(17), HTR6(1), HTR7(8) 9762946 251 116 231 186 159 35 8 25 24 0 0.0613 1.000 1.000 224 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(14), BTK(17), CALM1(1), CALM2(1), CD79A(2), CD79B(1), ELK1(2), FOS(2), GRB2(2), HRAS(4), JUN(1), LYN(7), MAP2K1(13), MAP3K1(3), MAPK14(5), MAPK3(1), MAPK8(2), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(11), RAC1(17), RAF1(8), SHC1(3), SOS1(9), SYK(16), SYT1(20), VAV1(16) 14803886 244 115 220 106 169 11 11 32 21 0 0.127 1.000 1.000 225 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(5), APAF1(6), ARHGDIB(3), BAG4(4), BCL2(2), BIRC2(5), BIRC3(8), CASP2(1), CASP3(2), CASP7(5), CASP8(9), CASP9(3), CFLAR(4), CHUK(2), CRADD(1), CYCS(1), DAXX(10), DFFA(2), DFFB(3), GSN(6), LMNA(9), LMNB1(2), LMNB2(4), MAP2K7(4), MAP3K1(3), MAP3K14(4), MAP3K5(18), MAPK8(2), MDM2(4), NFKB1(7), NFKBIA(2), NUMA1(8), PAK2(8), PRKCD(4), PRKDC(20), PSEN1(1), PSEN2(2), PTK2(8), RASA1(4), RB1(8), RELA(5), RIPK1(1), SPTAN1(8), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF1(6), TRAF2(3) 26807969 234 115 229 110 115 29 14 48 26 2 0.371 1.000 1.000 226 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(25), ATP4A(17), ATP4B(1), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(6), ATP5G2(1), ATP5H(1), ATP5J(2), ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A2(5), ATP6V0A4(20), ATP6V0D2(8), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C2(9), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), COX10(6), COX15(4), COX4I2(4), COX5B(1), COX6A1(1), COX6B1(1), COX6B2(1), COX6C(1), COX7B(1), COX7B2(2), COX8A(1), COX8C(1), CYC1(4), LHPP(1), NDUFA10(2), NDUFA12(1), NDUFA13(7), NDUFA4(1), NDUFA6(1), NDUFA9(2), NDUFAB1(1), NDUFB2(4), NDUFB3(1), NDUFB5(3), NDUFB6(2), NDUFC2(1), NDUFS2(2), NDUFS3(3), NDUFS4(3), NDUFS5(1), NDUFS6(2), NDUFS7(3), NDUFS8(3), NDUFV1(2), PPA1(1), PPA2(3), SDHA(3), SDHB(1), SDHC(3), SDHD(1), TCIRG1(3), UQCRC1(3), UQCRC2(3), UQCRFS1(2) 21730645 242 115 234 113 145 21 17 36 23 0 0.0873 1.000 1.000 227 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(6), ABO(5), B3GALNT1(6), B3GALT1(12), B3GALT2(1), B3GALT4(2), B3GALT5(1), B3GNT1(2), B3GNT2(2), B3GNT3(6), B3GNT4(4), B3GNT5(1), B4GALNT1(3), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT4(3), B4GALT6(1), FUT1(3), FUT2(3), FUT3(6), FUT4(2), FUT5(6), FUT6(4), FUT7(2), FUT9(25), GBGT1(2), PIGA(3), PIGB(4), PIGC(3), PIGF(2), PIGG(10), PIGH(1), PIGK(6), PIGL(2), PIGM(2), PIGN(4), PIGO(13), PIGQ(8), PIGS(1), PIGT(1), PIGU(7), PIGV(7), PIGX(2), PIGZ(3), ST3GAL1(6), ST3GAL2(1), ST3GAL3(2), ST3GAL4(1), ST3GAL5(2), ST3GAL6(2), ST6GALNAC3(6), ST6GALNAC4(1), ST6GALNAC5(7), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(9), UGCG(2) 18739389 236 115 231 131 139 24 13 34 26 0 0.320 1.000 1.000 228 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(6), BAX(3), BCL2(2), BIRC2(5), BIRC3(8), CASP2(1), CASP3(2), CASP7(5), CASP8(9), CASP9(3), CYCS(1), FAS(5), FASLG(14), GZMB(3), JUN(1), MAP2K4(4), MAP3K1(3), MAP3K14(4), MAPK10(9), MCL1(3), MDM2(4), MYC(5), NFKB1(7), NFKBIA(2), PARP1(10), PRF1(13), RELA(5), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TNFSF10(8), TP53(43), TRAF1(6), TRAF2(3) 14433242 205 114 195 76 114 21 15 23 32 0 0.0122 1.000 1.000 229 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(1), CDK5(4), CFL1(1), CHN1(6), LIMK1(4), MAP3K1(3), MYL2(5), MYLK(41), NCF2(7), PAK1(4), PDGFRA(32), PIK3CA(9), PIK3R1(7), PLD1(12), PPP1R12B(8), RAC1(17), RALBP1(2), RPS6KB1(2), TRIO(19), VAV1(16), WASF1(5) 13578447 205 114 188 112 135 12 12 25 20 1 0.658 1.000 1.000 230 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(7), EIF2B1(9), EIF2B2(2), EIF2B3(3), EIF2B4(1), EIF2B5(1), EIF2S1(1), ELAVL1(1), FLT1(33), FLT4(27), HIF1A(5), HRAS(4), KDR(45), NOS3(17), PIK3CA(9), PIK3R1(7), PLCG1(9), PRKCA(11), PTK2(8), PXN(3), SHC1(3), VHL(4) 13229941 210 114 194 105 133 16 5 26 29 1 0.374 1.000 1.000 231 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(12), ALOX12(5), ALOX15(9), ALOX5(9), CBR3(1), CYP4F2(12), CYP4F3(20), EPX(7), GGT1(7), LPO(18), LTA4H(4), MPO(11), PLA2G1B(1), PLA2G2A(2), PLA2G2E(4), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), PRDX1(2), PRDX2(2), PRDX6(4), PTGDS(2), PTGES2(2), PTGIS(12), PTGS1(17), PTGS2(11), TBXAS1(14), TPO(45) 10796515 276 113 266 166 211 22 3 21 19 0 0.118 1.000 1.000 232 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(49), C5(16), C6(66), C7(52), C8A(40), C9(22) 4823438 245 112 213 89 192 8 4 20 20 1 0.000805 1.000 1.000 233 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(6), AARS2(3), ABAT(9), ACY3(3), ADSL(7), ADSS(2), ADSSL1(8), AGXT(10), AGXT2(20), ASL(6), ASNS(9), ASPA(3), ASRGL1(3), ASS1(8), CAD(18), CRAT(6), DARS(4), DARS2(3), DDO(7), DLAT(2), DLD(2), GAD1(15), GAD2(10), GOT1(6), GOT2(7), GPT(3), GPT2(1), NARS(2), NARS2(5), PC(13), PDHA1(3), PDHA2(19), PDHB(1) 14699909 224 112 212 105 160 20 10 24 10 0 0.0276 1.000 1.000 234 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(9), ACAA1(6), ACAA2(2), ACADM(6), ACADS(4), ACAT2(1), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH6A1(5), ALDH7A1(10), ALDH9A1(3), AOX1(24), AUH(3), BCAT1(11), BCAT2(2), BCKDHA(2), BCKDHB(2), DBT(1), DLD(2), ECHS1(2), EHHADH(7), HADHA(8), HADHB(4), HIBADH(8), HIBCH(1), HMGCL(4), HMGCS1(2), HMGCS2(18), HSD17B10(2), HSD17B4(6), IVD(4), MCCC1(5), MCCC2(3), MCEE(2), MUT(7), OXCT1(5), OXCT2(4), PCCA(5), PCCB(3) 16743933 217 112 207 100 136 20 13 33 15 0 0.241 1.000 1.000 235 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(20), ACY3(3), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH7A1(10), ALDH9A1(3), AMDHD1(5), AOC2(8), AOC3(8), ASPA(3), CARM1(6), CNDP1(9), DDC(12), FTCD(3), HAL(12), HARS(6), HARS2(4), HDC(22), HEMK1(5), HNMT(1), LCMT1(4), MAOA(4), MAOB(13), METTL2B(8), METTL6(3), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), PRPS1(2), PRPS2(4), UROC1(13), WBSCR22(1) 15309621 249 112 242 152 165 26 14 24 20 0 0.461 1.000 1.000 236 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(4), ADRBK2(4), ARRB2(6), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CLCA1(7), CLCA2(10), CLCA4(30), CNGA3(26), CNGA4(14), CNGB1(21), GNAL(2), GUCA1A(5), GUCA1B(2), GUCA1C(7), PDC(6), PDE1C(44), PRKACA(4), PRKACB(4), PRKACG(8), PRKG1(13), PRKG2(16), PRKX(4) 11693170 267 112 254 148 185 22 7 32 21 0 0.229 1.000 1.000 237 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(29), AR(7), ESR1(5), ESR2(8), ESRRA(3), HNF4A(19), NPM1(3), NR0B1(2), NR1D2(10), NR1H2(3), NR1H3(3), NR1I2(3), NR1I3(7), NR2C2(2), NR2E1(4), NR2F1(8), NR2F2(2), NR2F6(1), NR3C1(7), NR4A1(4), NR4A2(4), NR5A1(7), NR5A2(19), PGR(15), PPARA(7), PPARD(3), PPARG(11), RARA(3), RARB(5), RARG(2), ROR1(13), RORA(4), RORC(8), RXRA(4), RXRB(4), RXRG(5), THRA(4), THRB(17), VDR(3) 16136915 268 112 258 134 194 22 5 26 21 0 0.0523 1.000 1.000 238 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(20), AGXT(10), AGXT2(20), ALAS1(1), ALAS2(5), AMT(2), AOC2(8), AOC3(8), BHMT(9), CBS(7), CHDH(7), CHKA(2), CHKB(3), CPT1B(10), CTH(1), DAO(10), DLD(2), DMGDH(12), GAMT(4), GARS(6), GATM(5), GCAT(5), GLDC(5), MAOA(4), MAOB(13), PEMT(2), PISD(2), PLCB2(10), PLCG1(9), PLCG2(25), PSPH(2), SARDH(20), SARS(10), SHMT1(1), SHMT2(3), TARS(2) 16300374 265 111 254 149 182 20 16 26 21 0 0.188 1.000 1.000 239 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(6), ARG1(2), ARG2(1), ASL(6), ASS1(8), CKM(2), CKMT1A(1), CKMT2(5), CPS1(22), DAO(10), EPRS(11), GAMT(4), GATM(5), GLUD1(2), GLUD2(4), GOT1(6), GOT2(7), LAP3(1), NOS1(65), NOS3(17), OAT(3), OTC(3), P4HA1(9), P4HA2(5), P4HA3(13), PRODH(1), PYCR1(2), PYCR2(2), RARS(7), RARS2(2) 13875997 232 111 220 128 161 24 9 17 21 0 0.271 1.000 1.000 240 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(29), AKT1(3), GNAI1(1), ITGAV(9), ITGB3(12), MAPK1(4), MAPK3(1), PDGFA(1), PDGFRA(32), PIK3CA(9), PIK3R1(7), PLCB1(52), PRKCA(11), PTK2(8), RAC1(17), SMPD1(3), SMPD2(2), SPHK1(1), SRC(1) 10673477 203 110 185 87 143 9 9 23 18 1 0.0234 1.000 1.000 241 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(1), EGFR(23), ELK1(2), GNAS(22), GRB2(2), HRAS(4), IGF1R(11), ITGB1(4), KLK2(2), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK3(1), MKNK1(5), MKNK2(2), MYC(5), NGFR(8), PDGFRA(32), PPP2CA(1), PTPRR(26), RAF1(8), RPS6KA1(9), RPS6KA5(4), SHC1(3), SOS1(9), SRC(1), STAT3(11) 12738504 217 110 204 101 142 19 13 30 13 0 0.153 1.000 1.000 242 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(9), ALPL(9), ALPP(11), ALPPL2(12), ASCC3(11), ATP13A2(10), DDX18(4), DDX19A(1), DDX23(5), DDX4(11), DDX41(6), DDX47(1), DDX50(5), DDX51(5), DDX52(4), DDX54(2), DDX55(3), DDX56(3), DHX58(4), ENTPD7(2), EP400(25), ERCC2(2), ERCC3(5), FPGS(3), GGH(2), IFIH1(13), MOV10L1(28), NUDT5(2), NUDT8(1), QDPR(3), RAD54B(6), RUVBL2(4), SETX(17), SKIV2L2(4), SMARCA2(11), SMARCA5(5), SPR(2) 24184123 251 110 239 138 162 17 12 32 28 0 0.650 1.000 1.000 243 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(6), AGTR1(11), ATF2(5), CALM1(1), CALM2(1), EGFR(23), ELK1(2), GNAQ(5), GRB2(2), HRAS(4), JUN(1), MAP2K1(13), MAP2K2(4), MAP2K4(4), MAP3K1(3), MAPK1(4), MAPK3(1), MAPK8(2), MEF2A(5), MEF2B(3), MEF2C(3), MEF2D(5), PAK1(4), PRKCA(11), PTK2(8), PTK2B(11), RAC1(17), RAF1(8), SHC1(3), SOS1(9), SRC(1), SYT1(20) 12947376 200 109 174 99 133 14 9 26 18 0 0.475 1.000 1.000 244 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(20), AGXT(10), AGXT2(20), AKR1B10(8), ALAS1(1), ALAS2(5), AMT(2), AOC2(8), AOC3(8), BHMT(9), CBS(7), CHDH(7), CHKA(2), CHKB(3), CTH(1), DAO(10), DLD(2), DMGDH(12), GAMT(4), GARS(6), GATM(5), GCAT(5), GLDC(5), GNMT(1), HSD3B7(3), MAOA(4), MAOB(13), PEMT(2), PHGDH(13), PIPOX(5), PISD(2), PSAT1(2), PSPH(2), RDH11(2), RDH12(2), RDH13(3), SARDH(20), SARS(10), SARS2(3), SDS(2), SHMT1(1), SHMT2(3), TARS(2), TARS2(7) 16567507 262 109 247 149 174 19 14 28 27 0 0.326 1.000 1.000 245 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(5), CHUK(2), ELK1(2), FOS(2), IKBKB(4), IRAK1(5), JUN(1), LY96(4), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP3K1(3), MAP3K14(4), MAP3K7(1), MAPK14(5), MAPK8(2), MYD88(3), NFKB1(7), NFKBIA(2), PPARA(7), RELA(5), TIRAP(1), TLR10(12), TLR2(17), TLR3(10), TLR4(34), TLR6(6), TLR7(16), TLR9(14), TOLLIP(1), TRAF6(5) 14048251 196 109 193 101 123 22 11 25 15 0 0.351 1.000 1.000 246 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(5), ACTN1(5), ACTN2(24), ACTN3(7), BCAR1(5), BCR(11), CAPN1(4), CAPNS1(1), CAV1(2), CRKL(2), CSK(1), FYN(7), GRB2(2), HRAS(4), ITGA1(18), ITGB1(4), JUN(1), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK3(1), MAPK8(2), PPP1R12B(8), PTK2(8), PXN(3), RAF1(8), RAP1A(2), ROCK1(5), SHC1(3), SOS1(9), SRC(1), TLN1(14), VCL(7), ZYX(7) 18081538 202 108 189 98 117 20 10 31 23 1 0.187 1.000 1.000 247 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(21), ACAT2(1), ADH5(3), AKR1B1(2), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH9A1(3), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(2), LDHA(6), LDHB(2), LDHC(5), LDHD(3), MDH1(1), MDH2(4), ME1(20), ME2(1), ME3(11), PC(13), PCK1(23), PDHA1(3), PDHA2(19), PDHB(1), PKLR(11), PKM2(5) 14353749 208 108 201 110 141 18 10 25 14 0 0.333 1.000 1.000 248 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(5), BLVRA(3), BLVRB(1), CP(12), CPOX(4), EPRS(11), FECH(3), GUSB(4), HCCS(2), HMBS(2), HMOX1(1), HMOX2(2), PPOX(3), UGT1A1(5), UGT1A10(15), UGT1A3(12), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(12), UGT1A8(7), UGT1A9(11), UGT2B15(29), UGT2B4(36), UROS(1) 10710479 205 107 192 95 138 19 13 13 21 1 0.0778 1.000 1.000 249 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(9), F2R(7), F2RL3(3), GNAI1(1), HRAS(4), ITGA1(18), ITGB1(4), MAP2K1(13), MAPK1(4), MAPK3(1), PLA2G4A(11), PLCB1(52), PRKCA(11), PTGS1(17), PTK2(8), RAF1(8), SRC(1), SYK(16), TBXAS1(14) 9428830 202 107 182 93 143 13 6 21 19 0 0.104 1.000 1.000 250 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(11), EGF(19), EGFR(23), GRB2(2), HRAS(4), MAP2K1(13), MAPK1(4), MAPK3(1), PTPRB(91), RAF1(8), RASA1(4), SHC1(3), SOS1(9), SPRY1(7), SPRY2(4), SPRY3(12), SPRY4(2), SRC(1) 9677005 218 107 197 92 152 16 9 25 16 0 0.151 1.000 1.000 251 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(17), DLG4(6), EPHB2(31), F2(9), F2RL1(16), F2RL2(6), F2RL3(3), JUN(1), MAP2K5(3), MAPK1(4), MAPK7(4), MAPK8(2), MYEF2(4), PLD1(12), PLD2(7), PLD3(1), PTK2(8), RAF1(8), RASAL1(15), SRC(1), TEC(10), VAV1(16) 10602856 184 107 176 114 105 18 7 37 17 0 0.876 1.000 1.000 252 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(6), ACAA2(2), ACADL(4), ACADM(6), ACADS(4), ACADSB(6), ACAT2(1), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH6A1(5), ALDH9A1(3), AOX1(24), BCAT1(11), BCKDHA(2), BCKDHB(2), ECHS1(2), EHHADH(7), HADHA(8), HADHB(4), HIBADH(8), HMGCL(4), IVD(4), MCCC1(5), MCCC2(3), MCEE(2), MUT(7), OXCT1(5), PCCA(5), PCCB(3), SDS(2) 14019237 186 107 178 88 120 16 9 25 16 0 0.297 1.000 1.000 253 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), DAG1(6), ITPKA(1), ITPKB(6), ITPR1(36), ITPR2(18), ITPR3(9), NFAT5(8), PDE6A(14), PDE6B(15), PDE6C(27), PDE6D(2), PDE6G(2), SLC6A13(27), TF(13) 13810178 206 106 193 115 144 14 7 20 21 0 0.125 1.000 1.000 254 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(13), ATR(25), BRCA1(9), CDC25A(8), CDC25B(6), CDC25C(5), CDC34(4), CDKN1A(4), CHEK1(2), CHEK2(2), EP300(14), MDM2(4), MYT1(22), PRKDC(20), RPS6KA1(9), TP53(43), WEE1(3), YWHAQ(3) 16304831 196 105 184 70 104 16 13 30 33 0 0.112 1.000 1.000 255 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(21), CALCR(17), CALCRL(15), CD97(6), CRHR1(7), CRHR2(4), ELTD1(25), EMR1(27), EMR2(5), GHRHR(4), GIPR(2), GLP1R(11), GLP2R(14), GPR64(6), LPHN1(9), LPHN2(38), LPHN3(21), SCTR(10), VIPR1(4), VIPR2(5) 10205512 251 105 234 157 176 19 14 20 22 0 0.266 1.000 1.000 256 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(3), ARSE(5), B4GALT6(1), CERK(1), DEGS1(1), DEGS2(4), ENPP7(6), GAL3ST1(9), GALC(4), GBA(5), GLA(1), GLB1(8), LCT(43), NEU1(7), NEU2(14), NEU3(3), NEU4(9), PPAP2B(9), PPAP2C(8), SGMS1(15), SGMS2(1), SGPP2(7), SMPD1(3), SMPD2(2), SMPD3(9), SMPD4(7), SPHK1(1), SPHK2(7), SPTLC1(1), SPTLC2(6), UGCG(2), UGT8(7) 13722229 209 105 199 133 147 15 5 26 16 0 0.767 1.000 1.000 257 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(6), AARS2(3), CARS(10), CARS2(2), DARS(4), DARS2(3), EPRS(11), FARS2(5), FARSA(6), FARSB(5), GARS(6), HARS(6), HARS2(4), IARS(8), IARS2(14), KARS(6), LARS(10), LARS2(5), MARS(6), MARS2(4), MTFMT(2), NARS(2), NARS2(5), QARS(6), RARS(7), RARS2(2), SARS(10), SARS2(3), TARS(2), TARS2(7), VARS(18), VARS2(6), WARS(4), WARS2(4), YARS(1), YARS2(2) 21221033 205 105 190 109 127 21 10 26 21 0 0.590 1.000 1.000 258 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(3), ACTR3(2), ARHGAP1(2), ARHGAP4(3), ARHGAP5(12), ARHGAP6(11), ARHGEF1(1), ARHGEF11(19), ARHGEF5(17), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), BAIAP2(7), CFL1(1), DIAPH1(6), GSN(6), LIMK1(4), MYL2(5), MYLK(41), OPHN1(4), PIP5K1A(6), PIP5K1B(20), PPP1R12B(8), ROCK1(5), SRC(1), TLN1(14), VCL(7) 17440939 212 105 203 108 150 14 7 26 15 0 0.141 1.000 1.000 259 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(3), GHR(30), GRB2(2), HRAS(4), INSR(22), IRS1(6), JAK2(9), MAP2K1(13), MAPK1(4), MAPK3(1), PIK3CA(9), PIK3R1(7), PLCG1(9), PRKCA(11), PTPN6(3), RAF1(8), RPS6KA1(9), SHC1(3), SLC2A4(8), SOS1(9), SRF(2), STAT5A(3), STAT5B(4) 12856459 179 104 165 89 105 14 10 30 19 1 0.441 1.000 1.000 260 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(29), CALM1(1), CALM2(1), ELK1(2), FOS(2), GNAI1(1), GNAQ(5), GNAS(22), HRAS(4), JUN(1), MAP2K1(13), MAPK3(1), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(11), RAF1(8), RPS6KA3(2), SYT1(20) 13455083 212 104 196 122 143 15 10 24 20 0 0.800 1.000 1.000 261 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(5), CRK(3), CXCL12(2), CXCR4(4), GNAI1(1), GNAQ(5), HRAS(4), MAP2K1(13), MAPK1(4), MAPK3(1), NFKB1(7), PIK3C2G(50), PIK3CA(9), PIK3R1(7), PLCG1(9), PRKCA(11), PTK2(8), PTK2B(11), PXN(3), RAF1(8), RELA(5) 10642526 170 103 153 80 110 11 5 26 17 1 0.265 1.000 1.000 262 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(3), APC(22), AXIN1(11), CCND1(1), CD14(5), CTNNB1(13), FZD1(4), GJA1(8), GNAI1(1), GSK3B(2), IRAK1(5), LBP(9), LEF1(3), LY96(4), MYD88(3), NFKB1(7), PDPK1(4), PIK3CA(9), PIK3R1(7), PPP2CA(1), RELA(5), TIRAP(1), TLR4(34), TOLLIP(1), WNT1(2) 11777732 165 103 160 79 97 13 12 21 21 1 0.443 1.000 1.000 263 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(20), ALDH1A3(2), ALDH3A1(7), ALDH3B1(2), ALDH3B2(7), AOC2(8), AOC3(8), DDC(12), EPX(7), ESCO1(2), ESCO2(3), GOT1(6), GOT2(7), HPD(5), LPO(18), MAOA(4), MAOB(13), MPO(11), MYST3(16), MYST4(16), NAT6(2), PNPLA3(2), PRDX6(4), SH3GLB1(2), TAT(17), TPO(45) 13279656 246 103 239 154 181 21 12 18 14 0 0.679 1.000 1.000 264 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(2), ALG10(4), ALG10B(4), ALG12(1), ALG13(9), ALG14(2), ALG2(4), ALG3(4), ALG5(2), ALG6(3), ALG8(6), ALG9(5), B4GALT1(2), B4GALT2(2), B4GALT3(3), DAD1(1), DDOST(3), DHDDS(1), DOLPP1(4), DPAGT1(2), DPM1(1), FUT8(8), GANAB(5), MAN1A1(17), MAN1A2(6), MAN1B1(4), MAN1C1(8), MAN2A1(10), MGAT1(3), MGAT2(3), MGAT3(10), MGAT4A(8), MGAT4B(1), MGAT5(5), MGAT5B(10), RFT1(3), RPN2(2), ST6GAL1(5), STT3B(7) 16408317 180 102 175 98 107 19 12 19 23 0 0.417 1.000 1.000 265 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(9), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3), CYP2C19(42), CYP2C9(38), DHRS1(3), DHRS2(7), DHRS3(4), DHRS7(1), DHRSX(4), ECHS1(2), EHHADH(7), ESCO1(2), ESCO2(3), HADHA(8), MYST3(16), MYST4(16), NAT6(2), PNPLA3(2), SH3GLB1(2), YOD1(1) 12028011 206 102 193 130 133 20 11 27 15 0 0.931 1.000 1.000 266 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(4), APC(22), ATF2(5), AXIN1(11), BMP10(15), BMP2(6), BMP4(3), BMP5(27), BMP7(2), BMPR1A(2), BMPR2(6), CHRD(14), CTNNB1(13), FZD1(4), GATA4(3), GSK3B(2), MAP3K7(1), MEF2C(3), MYL2(5), NKX2-5(2), NOG(1), NPPA(3), NPPB(5), RFC1(7), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(7), TGFBR3(6), WNT1(2) 14011168 186 101 175 88 123 16 7 19 21 0 0.432 1.000 1.000 267 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(12), DIAPH1(6), FYN(7), GSN(6), HRAS(4), ITGA1(18), ITGB1(4), MAP2K1(13), MAPK1(4), MAPK3(1), MYL2(5), MYLK(41), PIK3CA(9), PIK3R1(7), PTK2(8), PXN(3), RAF1(8), ROCK1(5), SHC1(3), SRC(1), TLN1(14) 14459907 179 101 161 88 116 12 7 26 17 1 0.386 1.000 1.000 268 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(3), EIF4A1(3), EIF4A2(4), EIF4E(1), EIF4EBP1(1), EIF4G1(14), EIF4G2(5), EIF4G3(17), GHR(30), IRS1(6), MAPK1(4), MAPK14(5), MAPK3(1), MKNK1(5), PABPC1(5), PDK2(4), PDPK1(4), PIK3CA(9), PIK3R1(7), PRKCA(11), PTEN(23), RPS6KB1(2) 10967969 164 101 154 55 84 15 12 16 36 1 0.0515 1.000 1.000 269 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(5), CALM1(1), CALM2(1), CRKL(2), GNAQ(5), GRB2(2), HRAS(4), JUN(1), MAP2K1(13), MAP2K2(4), MAP2K3(9), MAP2K4(4), MAP3K1(3), MAPK1(4), MAPK14(5), MAPK3(1), MAPK8(2), PAK1(4), PLCG1(9), PRKCA(11), PTK2B(11), RAC1(17), RAF1(8), SHC1(3), SOS1(9), SRC(1), SYT1(20) 11022390 159 101 136 78 102 13 7 24 13 0 0.409 1.000 1.000 270 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(5), AKT1(3), AKT2(8), AKT3(4), DAG1(6), GNAQ(5), ITPKA(1), ITPKB(6), ITPR1(36), ITPR2(18), ITPR3(9), NFKB1(7), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PDK1(2), PHKA2(7), PIK3CB(26), PITX2(4), PLD1(12), PLD2(7), PLD3(1) 17347085 182 101 171 107 86 19 15 41 21 0 0.700 1.000 1.000 271 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(6), BAX(3), BCL2(2), BCL2A1(1), BCL2L2(2), CASP1(5), CASP10(5), CASP2(1), CASP3(2), CASP4(1), CASP7(5), CASP8(9), CASP9(3), CD40(4), CD40LG(2), CRADD(1), CYCS(1), DAXX(10), DFFA(2), DFFB(3), FAS(5), FASLG(14), IKBKE(12), LTA(2), MCL1(3), NFKB1(7), NFKBIA(2), NGFR(8), NR3C1(7), NTRK1(19), PTPN13(13), RIPK1(1), SFRS2IP(7), TFG(2), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF1(6), TRAF2(3), TRAF3(5), TRAF6(5) 16788612 196 100 193 106 126 17 9 23 21 0 0.702 1.000 1.000 272 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(3), AKT2(8), AKT3(4), CISH(3), GRB2(2), IARS(8), IL13RA1(3), IL2RG(3), IL4(1), IL4R(14), INPP5D(37), JAK1(6), JAK2(9), JAK3(7), NR0B2(6), PI3(6), PIK3CA(9), PPP1R13B(8), RPS6KB1(2), SERPINA4(16), SHC1(3), SOS1(9), SOS2(13), SRC(1), STAT6(8), TYK2(8) 14269179 197 100 190 88 129 14 10 26 18 0 0.183 1.000 1.000 273 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(13), ATR(25), BRCA1(9), BRCA2(21), CHEK1(2), CHEK2(2), FANCA(7), FANCC(3), FANCD2(13), FANCE(2), FANCF(1), FANCG(4), HUS1(1), MRE11A(6), RAD1(2), RAD17(5), RAD50(5), RAD51(1), RAD9A(6), TP53(43) 17121482 171 99 160 65 100 5 11 23 32 0 0.270 1.000 1.000 274 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ACAD9(1), ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(6), DHRS1(3), DHRS2(7), DHRS3(4), DHRS7(1), DHRSX(4), ESCO1(2), ESCO2(3), MYST3(16), MYST4(16), NAT6(2), PNPLA3(2), SH3GLB1(2) 9724311 183 99 161 84 130 15 8 23 7 0 0.281 1.000 1.000 275 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(4), ANXA2(2), ANXA3(4), ANXA4(2), ANXA5(1), ANXA6(6), CYP11A1(15), EDN1(9), EDNRA(9), EDNRB(5), HPGD(1), HSD11B1(11), HSD11B2(2), PLA2G4A(11), PRL(1), PTGDR(9), PTGDS(2), PTGER2(6), PTGER4(1), PTGFR(22), PTGIR(6), PTGIS(12), PTGS1(17), PTGS2(11), S100A6(1), SCGB1A1(1), TBXAS1(14) 7930785 185 99 176 79 130 18 3 16 18 0 0.00154 1.000 1.000 276 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(3), BCL2(2), EGFR(23), IGF1R(11), MYC(5), POLR2A(12), PPP2CA(1), PRKCA(11), RB1(8), TEP1(31), TERF1(2), TERT(9), TNKS(7), TP53(43), XRCC5(2) 10904582 170 99 159 79 98 13 13 18 26 2 0.140 1.000 1.000 277 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(3), CABIN1(11), CALM1(1), CALM2(1), CAMK1(5), CAMK1G(11), HDAC5(7), IGF1(11), IGF1R(11), INSR(22), MAP2K6(3), MAPK14(5), MAPK7(4), MEF2A(5), MEF2B(3), MEF2C(3), MEF2D(5), MYOD1(1), NFATC1(15), NFATC2(9), PIK3CA(9), PIK3R1(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYT1(20) 13500616 183 98 175 98 119 15 6 26 16 1 0.404 1.000 1.000 278 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(3), ACP2(2), ACP5(3), ACP6(11), ACPP(8), ACPT(1), ALPI(9), ALPL(9), ALPP(11), ALPPL2(12), CMBL(4), CYP3A4(20), CYP3A43(16), CYP3A5(10), CYP3A7(21), DHRS1(3), DHRS2(7), DHRS3(4), DHRS7(1), DHRSX(4), PON1(15), PON2(1), PON3(6) 6959171 181 98 170 63 131 13 8 12 17 0 2.70e-05 1.000 1.000 279 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(9), ACACA(21), ACACB(21), ACADM(6), ACAT2(1), ACSS1(1), ACSS2(4), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH6A1(5), ALDH7A1(10), ALDH9A1(3), ECHS1(2), EHHADH(7), HADHA(8), HIBCH(1), LDHA(6), LDHAL6A(5), LDHAL6B(7), LDHB(2), LDHC(5), MCEE(2), MLYCD(3), MUT(7), PCCA(5), PCCB(3), SUCLG1(2), SUCLG2(2) 15445376 172 97 165 87 103 16 14 28 11 0 0.395 1.000 1.000 280 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(5), ACTG2(5), ADCY3(4), ADCY9(9), AK1(1), ARF4(3), ARF5(1), ARL4D(3), ATP6V0A1(9), ATP6V0A2(5), ATP6V0A4(20), ATP6V0D2(8), ATP6V0E1(1), ATP6V1A(3), ATP6V1C2(9), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), ERO1L(5), GNAS(22), PDIA4(4), PLCG1(9), PLCG2(25), PRKCA(11), SEC61A1(2), SEC61A2(8), TRIM23(2) 14377298 191 97 185 124 129 9 9 26 18 0 0.749 1.000 1.000 281 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(4), UCHL1(5), UCHL3(2), UGDH(1), UGT1A1(5), UGT1A10(15), UGT1A3(12), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(12), UGT1A8(7), UGT1A9(11), UGT2B15(29), UGT2B4(36) 6866448 165 97 149 82 114 16 11 8 15 1 0.0990 1.000 1.000 282 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(5), CR1(54), CR2(33), FCGR2B(3), HLA-DRA(11), HLA-DRB1(4), ICAM1(3), ITGAL(24), ITGB2(14), PTPRC(33) 5824251 184 96 176 70 125 15 5 15 24 0 0.0206 1.000 1.000 283 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(6), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3) 5130789 156 96 133 59 112 15 9 14 6 0 0.00176 1.000 1.000 284 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(6), HLA-A(3), IL18(2), ITGB1(4), KLRC1(5), KLRC2(1), KLRC3(11), KLRC4(5), KLRD1(5), LAT(1), MAP2K1(13), MAPK3(1), PAK1(4), PIK3CA(9), PIK3R1(7), PTK2B(11), PTPN6(3), RAC1(17), SYK(16), VAV1(16) 7190747 140 96 118 67 99 5 3 16 16 1 0.307 1.000 1.000 285 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(5), CDC42(3), DAXX(10), DDIT3(2), ELK1(2), GRB2(2), HMGN1(2), HRAS(4), HSPB1(2), HSPB2(1), MAP2K4(4), MAP2K6(3), MAP3K1(3), MAP3K5(18), MAP3K7(1), MAP3K9(24), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MEF2A(5), MEF2B(3), MEF2C(3), MEF2D(5), MKNK1(5), MYC(5), PLA2G4A(11), RAC1(17), RIPK1(1), RPS6KA5(4), SHC1(3), STAT1(4), TGFB1(1), TGFB2(1), TGFB3(3), TRAF2(3) 14078952 171 96 158 63 111 14 4 23 19 0 0.0509 1.000 1.000 286 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(4), JAK1(6), JUN(1), MAP2K1(13), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(2), PDGFA(1), PDGFRA(32), PIK3CA(9), PIK3R1(7), PLCG1(9), PRKCA(11), RAF1(8), RASA1(4), SHC1(3), SOS1(9), SRF(2), STAT1(4), STAT3(11), STAT5A(3) 13510805 154 96 144 64 84 16 9 27 17 1 0.251 1.000 1.000 287 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(20), ALDH1A3(2), ALDH3A1(7), ALDH3B1(2), ALDH3B2(7), AOC2(8), AOC3(8), DDC(12), EPX(7), GOT1(6), GOT2(7), HPD(5), LPO(18), MAOA(4), MAOB(13), MPO(11), PRDX1(2), PRDX2(2), PRDX6(4), TAT(17), TPO(45) 8489581 207 96 201 125 159 17 9 10 12 0 0.115 1.000 1.000 288 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(9), CARM1(6), CCND1(1), CREBBP(23), EP300(14), ERCC3(5), ESR1(5), GRIP1(10), GTF2A1(2), GTF2E1(2), GTF2F1(5), HDAC1(1), HDAC2(1), HDAC3(6), HDAC4(10), HDAC5(7), HDAC6(2), MEF2C(3), NCOR2(26), NR0B1(2), NRIP1(9), PELP1(12), POLR2A(12), TBP(4) 17607210 177 95 176 87 120 6 11 26 14 0 0.484 1.000 1.000 289 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(29), AKT1(3), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), GNAS(22), GRB2(2), HRAS(4), MAPK1(4), MAPK14(5), MAPK3(1), PIK3CA(9), PIK3R1(7), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(11), RAC1(17), RPS6KA1(9), RPS6KA5(4), SOS1(9) 11205701 181 95 166 101 123 13 8 17 19 1 0.695 1.000 1.000 290 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(18), CD2(23), CD33(18), CD5(7), CSF2(2), IFNA1(1), IFNB1(6), IFNG(2), IL10(3), IL12A(3), IL12B(4), IL13(2), IL3(3), IL4(1), IL5(4), ITGAX(20), TLR2(17), TLR4(34), TLR7(16), TLR9(14) 7191921 198 95 190 104 137 17 10 15 19 0 0.00446 1.000 1.000 291 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(20), ACY1(2), ADC(5), AGMAT(3), ALDH18A1(7), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3), AOC2(8), AOC3(8), ARG1(2), ARG2(1), ASL(6), ASS1(8), CPS1(22), GATM(5), MAOA(4), MAOB(13), NAGS(1), ODC1(3), OTC(3), SAT2(1), SMS(6) 11310425 165 95 160 99 99 18 13 17 18 0 0.562 1.000 1.000 292 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(6), ICAM1(3), ITGA4(38), ITGAL(24), ITGAM(21), ITGB1(4), ITGB2(14), SELE(36), SELL(8), SELP(31) 6115804 185 95 176 59 139 4 6 14 22 0 0.000248 1.000 1.000 293 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(9), EEF1B2(1), EEF1D(1), EEF1G(1), EEF2(2), EEF2K(7), EIF1AX(3), EIF2AK1(4), EIF2AK2(6), EIF2AK3(19), EIF2B1(9), EIF2B2(2), EIF2B3(3), EIF2B4(1), EIF2B5(1), EIF2S1(1), EIF4A1(3), EIF4A2(4), EIF4E(1), EIF4EBP1(1), EIF4G1(14), EIF4G3(17), EIF5(2), EIF5B(2), ETF1(2), GSPT2(8), KIAA0664(4), PABPC1(5), PABPC3(10), PAIP1(7), SLC35A4(4) 16919858 154 95 145 82 77 13 11 22 31 0 0.906 1.000 1.000 294 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(6), AZIN1(1), BTG1(2), CBX3(1), CLOCK(5), CRY1(7), CRY2(3), DAZAP2(1), DNAJA1(1), EIF4G2(5), ETV6(13), GFRA1(8), GSTM3(4), GSTP1(2), HERPUD1(3), HSPA8(5), IDI1(1), KLF9(2), MYF6(12), NCKAP1(7), NCOA4(5), NR1D2(10), PER1(8), PER2(13), PIGF(2), PPP1R3C(3), PPP2CB(2), PSMA4(2), PURA(3), SF3A3(4), TOB1(3), TUBB3(5), UCP3(4), UGP2(2), VAPA(1), ZFR(9) 14149570 165 94 162 73 79 15 14 32 25 0 0.601 1.000 1.000 295 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(10), F2(9), F2R(7), F3(2), F5(37), F7(9), FGA(42), FGB(10), FGG(8), PROC(9), PROS1(13), SERPINC1(8), TFPI(10) 6366933 174 94 159 71 116 21 10 17 10 0 0.0948 1.000 1.000 296 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(28), F2(9), F2R(7), FGA(42), FGB(10), FGG(8), PLAT(4), PLAU(3), PLG(33), SERPINB2(19), SERPINE1(5) 5178375 169 94 157 68 125 13 8 14 9 0 0.0645 1.000 1.000 297 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(20), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH9A1(3), AOC2(8), AOC3(8), ASPA(3), CNDP1(9), DDC(12), HAL(12), HARS(6), HDC(22), HNMT(1), MAOA(4), MAOB(13), PRPS1(2), PRPS2(4) 9423316 177 94 172 112 119 17 10 14 17 0 0.532 1.000 1.000 298 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(2), EXT2(6), EXTL1(2), EXTL3(11), GLCE(9), HS2ST1(1), HS3ST1(11), HS3ST2(8), HS3ST3A1(4), HS3ST3B1(2), HS3ST5(8), HS6ST1(3), HS6ST2(3), HS6ST3(16), NDST1(4), NDST2(2), NDST3(25), NDST4(50) 7885528 167 94 160 87 109 13 6 20 19 0 0.179 1.000 1.000 299 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(17), ANAPC10(1), ANAPC2(5), ANAPC4(4), ANAPC5(7), ANAPC7(6), BTRC(5), CDC16(2), CDC20(1), CDC23(3), CDC27(10), CUL1(7), CUL2(4), CUL3(6), FBXW11(5), FBXW7(12), FZR1(7), ITCH(8), SKP2(2), SMURF1(1), SMURF2(9), TCEB1(1), TCEB2(1), UBA1(3), UBE2D1(1), UBE2D3(3), UBE2E1(1), UBE2E2(4), UBE2E3(1), VHL(4), WWP1(3), WWP2(7) 15467801 151 94 143 63 90 5 13 24 18 1 0.469 1.000 1.000 300 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(5), CAPN1(4), CAPN2(6), CAPNS1(1), CXCR3(5), EGF(19), EGFR(23), HRAS(4), ITGA1(18), ITGB1(4), MAPK1(4), MAPK3(1), MYL2(5), MYLK(41), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PTK2(8), PXN(3), TLN1(14) 12574382 188 94 181 115 132 11 10 19 16 0 0.639 1.000 1.000 301 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(29), ARHGEF1(1), F2(9), F2R(7), F2RL3(3), GNA12(3), GNA13(1), GNAI1(1), GNAQ(5), MAP3K7(1), PIK3CA(9), PIK3R1(7), PLCB1(52), PPP1R12B(8), PRKCA(11), PTK2B(11), ROCK1(5) 10013679 163 94 154 84 110 11 7 20 14 1 0.371 1.000 1.000 302 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 GORASP1(1), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(2), MAPK13(5), MAPK14(5), MAPK3(1), MAPK8(2), MAPK8IP1(5), MAPK8IP2(9), MAPK8IP3(9), MAPK9(7), MAPKAPK5(1), NFKB1(7), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PIK3CA(9), PIK3CD(7), PIK3R1(7), SYT1(20), TRAF2(3), TRAF3(5), TRAF5(7), TRAF6(5) 12946036 154 94 148 88 96 9 8 26 14 1 0.564 1.000 1.000 303 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(3), ATF1(5), CDC42(3), CREB3(1), CREB5(11), DUSP10(6), EEF2K(7), EIF4E(1), ELK1(2), HSPB1(2), IL1R1(12), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP3K10(8), MAP3K4(16), MAP3K5(18), MAP3K7(1), MAPK1(4), MAPK11(1), MAPK12(2), MAPK13(5), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MKNK1(5), MKNK2(2), MYEF2(4), NFKB1(7), NR2C2(2), SRF(2), TRAF6(5) 12892531 162 94 158 86 107 12 4 24 15 0 0.526 1.000 1.000 304 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(29), CD3D(5), CD3E(2), CD3G(1), CD4(6), CREBBP(23), CSK(1), GNAS(22), HLA-DRA(11), HLA-DRB1(4), LCK(14), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PTPRC(33), ZAP70(7) 8778424 181 93 174 99 125 14 8 18 16 0 0.480 1.000 1.000 305 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(29), CD3D(5), CD3E(2), CD3G(1), CD4(6), CREBBP(23), CSK(1), GNAS(22), HLA-DRA(11), HLA-DRB1(4), LCK(14), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PTPRC(33), ZAP70(7) 8778424 181 93 174 99 125 14 8 18 16 0 0.480 1.000 1.000 306 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(9), ADC(5), ALDH4A1(6), ALDH5A1(11), CAD(18), CPS1(22), EPRS(11), GAD1(15), GAD2(10), GCLC(5), GCLM(2), GFPT1(4), GFPT2(5), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(2), GMPS(6), GOT1(6), GOT2(7), GPT(3), GPT2(1), GSR(3), GSS(7), NADSYN1(4), NAGK(1), QARS(6) 15325230 180 93 173 94 104 22 11 28 15 0 0.363 1.000 1.000 307 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(4), ARSB(1), FUCA1(3), GALNS(4), GBA(5), GLB1(8), GNS(2), GUSB(4), HEXA(7), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(4), HYAL1(2), HYAL2(1), IDS(9), IDUA(4), LCT(43), MAN2B1(7), MAN2B2(8), MAN2C1(3), MANBA(7), NAGLU(4), NEU1(7), NEU2(14), NEU3(3), NEU4(9), SPAM1(23) 13222978 205 93 198 106 149 15 5 20 16 0 0.189 1.000 1.000 308 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(35), ACE2(8), AGT(6), AGTR1(11), AGTR2(12), ANPEP(18), CMA1(6), CPA3(18), CTSA(4), CTSG(4), ENPEP(33), LNPEP(10), MAS1(4), MME(21), NLN(5), REN(9), THOP1(7) 8163411 211 93 200 114 150 17 13 12 19 0 0.120 1.000 1.000 309 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(9), ACACA(21), ACADL(4), ACADM(6), ACADSB(6), ACAT2(1), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH6A1(5), ALDH9A1(3), ECHS1(2), EHHADH(7), HADHA(8), LDHA(6), LDHB(2), LDHC(5), MCEE(2), MLYCD(3), MUT(7), PCCA(5), PCCB(3), SDS(2), SUCLG1(2), SUCLG2(2) 12892648 152 93 147 73 97 13 10 23 9 0 0.391 1.000 1.000 310 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(6), BCL2(2), BIRC2(5), BIRC3(8), CASP10(5), CASP3(2), CASP7(5), CASP8(9), CASP9(3), CFLAR(4), CHUK(2), CYCS(1), DFFA(2), DFFB(3), GAS2(13), LMNA(9), MAP3K14(4), NFKB1(7), NFKBIA(2), RELA(5), RIPK1(1), SPTAN1(8), TNFRSF10A(5), TNFRSF10B(3), TNFRSF25(5), TNFSF10(8), TNFSF12(1), TRAF2(3) 12955017 131 92 129 78 75 17 10 20 9 0 0.867 1.000 1.000 311 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), EGF(19), EGFR(23), ELK1(2), FOS(2), GRB2(2), HRAS(4), JAK1(6), JUN(1), MAP2K1(13), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(2), PIK3CA(9), PIK3R1(7), PLCG1(9), PRKCA(11), RAF1(8), RASA1(4), SHC1(3), SOS1(9), SRF(2), STAT1(4), STAT3(11), STAT5A(3) 14508865 163 92 153 82 92 15 11 28 16 1 0.768 1.000 1.000 312 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(2), GTF2A1L(5), GTF2A2(1), GTF2B(3), GTF2E1(2), GTF2E2(5), GTF2F1(5), GTF2F2(2), GTF2H1(3), GTF2H3(1), GTF2H4(2), GTF2I(3), GTF2IRD1(9), STON1(1), TAF1(10), TAF13(2), TAF1L(59), TAF2(5), TAF4(9), TAF4B(3), TAF5L(3), TAF6(4), TAF6L(4), TAF7(2), TAF7L(11), TAF9(2), TAF9B(1), TBPL1(1), TBPL2(4) 14050445 164 92 158 70 113 13 6 23 9 0 0.286 1.000 1.000 313 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(22), CAMP(1), CASP3(2), CERK(1), CREB3(1), CREB5(11), DAG1(6), EPHB2(31), FOS(2), GNAQ(5), ITPKA(1), ITPKB(6), JUN(1), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(9), MAPK8(2), MAPK8IP1(5), MAPK8IP2(9), MAPK8IP3(9), MAPK9(7) 11016852 143 92 141 77 89 9 5 19 21 0 0.691 1.000 1.000 314 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(29), AKT1(3), BAX(3), BCL2(2), CSF2RB(18), IGF1(11), IGF1R(11), IL3(3), IL3RA(8), KIT(10), KITLG(9), PIK3CA(9), PIK3R1(7), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5) 8486341 146 91 140 85 91 13 9 13 19 1 0.516 1.000 1.000 315 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(11), BCAT2(2), COASY(3), DPYD(61), DPYS(24), ENPP1(13), ENPP3(15), ILVBL(4), PANK1(2), PANK2(3), PANK3(4), PANK4(6), PPCS(3), UPB1(6), VNN1(8) 6692519 165 91 149 50 118 13 5 17 12 0 0.000125 1.000 1.000 316 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(2), IFNA1(1), IFNB1(6), IKBKB(4), IL1A(4), IL1B(7), IL1R1(12), IL1RAP(4), IL1RN(8), IL6(2), IRAK1(5), IRAK2(14), IRAK3(7), JUN(1), MAP2K3(9), MAP2K6(3), MAP3K1(3), MAP3K14(4), MAP3K7(1), MAPK14(5), MAPK8(2), MYD88(3), NFKB1(7), NFKBIA(2), RELA(5), TGFB1(1), TGFB2(1), TGFB3(3), TNF(1), TOLLIP(1), TRAF6(5) 11423591 133 91 130 70 82 14 5 18 14 0 0.467 1.000 1.000 317 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(3), BCL2(2), CBL(11), CFLAR(4), CRKL(2), E2F1(7), FOS(2), GRB2(2), HRAS(4), IL2RA(4), IL2RB(7), IL2RG(3), IRS1(6), JAK1(6), JAK3(7), MAPK1(4), MAPK3(1), MYC(5), NMI(1), PIK3CA(9), PIK3R1(7), PPIA(1), PTPN6(3), RAF1(8), RPS6KB1(2), SHC1(3), SOCS3(2), SOS1(9), STAT5A(3), STAT5B(4), SYK(16) 13944714 148 91 145 73 80 13 13 22 19 1 0.527 1.000 1.000 318 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(22), AXIN1(11), CREBBP(23), CTNNB1(13), EP300(14), FZD1(4), GSK3B(2), HDAC1(1), LDB1(2), LEF1(3), PITX2(4), TRRAP(40), WNT1(2) 12887740 141 91 137 80 77 10 11 24 19 0 0.932 1.000 1.000 319 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(6), ABAT(9), ADSL(7), ADSS(2), AGXT(10), AGXT2(20), ASL(6), ASNS(9), ASPA(3), CAD(18), CRAT(6), DARS(4), DDO(7), GAD1(15), GAD2(10), GOT1(6), GOT2(7), GPT(3), GPT2(1), NARS(2), PC(13) 10140361 164 90 156 80 115 16 9 17 7 0 0.0480 1.000 1.000 320 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(7), ABAT(9), ACADS(4), ACAT2(1), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH5A1(11), ALDH9A1(3), ECHS1(2), EHHADH(7), GAD1(15), GAD2(10), HADHA(8), HMGCL(4), L2HGDH(3), OXCT1(5), PDHA1(3), PDHA2(19), PDHB(1), SDHB(1), SDS(2) 10054525 156 90 150 71 101 17 4 20 14 0 0.0666 1.000 1.000 321 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(10), ACO1(5), ACO2(5), CLYBL(5), CS(2), DLD(2), FH(3), IDH1(15), IDH2(2), IDH3A(3), IDH3B(1), IDH3G(2), MDH1(1), MDH2(4), OGDH(11), OGDHL(41), PC(13), PCK1(23), PCK2(4), SDHA(3), SDHB(1), SDHC(3), SDHD(1), SUCLG1(2), SUCLG2(2) 11634860 164 90 147 80 115 8 7 20 14 0 0.0958 1.000 1.000 322 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(5), AASDH(5), AASDHPPT(3), AASS(4), ACAT2(1), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH9A1(3), BBOX1(5), DOT1L(11), ECHS1(2), EHHADH(7), EHMT1(8), EHMT2(9), GCDH(5), HADHA(8), PLOD1(5), PLOD2(7), PLOD3(5), SDS(2), SHMT1(1), SHMT2(3), TMLHE(2) 14269128 142 90 138 78 91 17 4 20 10 0 0.431 1.000 1.000 323 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(25), ATP4B(1), ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(20), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C2(9), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), ATP7A(9), ATP7B(19), COX10(6), COX5B(1), COX6A1(1), COX6B1(1), COX6C(1), COX7B(1), COX8A(1), NDUFA10(2), NDUFA4(1), NDUFB2(4), NDUFB5(3), NDUFB6(2), NDUFS2(2), NDUFV1(2), PPA2(3), SDHA(3), SDHB(1), SHMT1(1), UQCRC1(3), UQCRFS1(2) 14882681 166 90 165 99 100 9 19 22 16 0 0.785 1.000 1.000 324 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(2), POLA2(9), POLD1(6), POLD2(2), POLD3(4), POLE(16), POLE2(3), POLG(9), POLG2(7), POLH(3), POLI(4), POLK(6), POLL(7), POLM(2), POLQ(25), PRIM1(3), PRIM2(15), REV1(6), REV3L(13) 15703732 142 89 139 58 79 8 8 30 17 0 0.383 1.000 1.000 325 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(3), CASP10(5), CASP3(2), CASP7(5), CASP8(9), CFLAR(4), DAXX(10), DFFA(2), DFFB(3), FAF1(7), JUN(1), LMNA(9), LMNB1(2), LMNB2(4), MAP2K4(4), MAP3K1(3), MAP3K7(1), MAPK8(2), PAK1(4), PAK2(8), PRKDC(20), PTPN13(13), RB1(8), RIPK2(3), SPTAN1(8) 15899979 140 87 138 68 66 14 10 32 16 2 0.785 1.000 1.000 326 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(2), CREBBP(23), EP300(14), FYN(7), IL2RG(3), IL7(5), IL7R(33), JAK1(6), JAK3(7), LCK(14), NMI(1), PIK3CA(9), PIK3R1(7), PTK2B(11), STAT5A(3), STAT5B(4) 10809498 149 87 144 71 86 15 7 24 16 1 0.460 1.000 1.000 327 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(12), ABCC2(10), ABCG2(7), BCHE(6), CES1(16), CES2(5), CYP3A4(20), CYP3A5(10), UGT1A1(5), UGT1A10(15), UGT1A3(12), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(12), UGT1A8(7), UGT1A9(11) 8885713 172 87 161 78 118 15 11 11 17 0 0.00595 1.000 1.000 328 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(11), COASY(3), DPYD(61), DPYS(24), ENPP1(13), ENPP3(15), PANK1(2), PANK2(3), PANK3(4), PANK4(6), PPCS(3), UPB1(6) 5393414 151 87 135 44 106 13 5 16 11 0 0.000437 1.000 1.000 329 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(12), ATM(13), BRCA1(9), CDKN1A(4), CHEK1(2), CHEK2(2), JUN(1), MAPK8(2), MDM2(4), MRE11A(6), NFKB1(7), NFKBIA(2), RAD50(5), RAD51(1), RBBP8(5), RELA(5), TP53(43), TP73(5) 11514338 128 86 118 42 59 13 8 22 26 0 0.132 1.000 1.000 330 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(11), CSF1R(13), EGF(19), EGFR(23), GRB2(2), MET(23), PDGFRA(32), PRKCA(11), SH3GLB1(2), SH3GLB2(1), SH3KBP1(6), SRC(1) 7556092 144 86 143 83 92 13 9 16 14 0 0.773 1.000 1.000 331 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(17), FOS(2), HRAS(4), JUN(1), MAP2K1(13), MAPK1(4), MAPK3(1), MYC(5), NFKB1(7), NFKBIA(2), PLCB1(52), PRKCA(11), RAF1(8), RELA(5), TNF(1) 6038539 133 86 118 57 92 8 7 16 10 0 0.0440 1.000 1.000 332 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(3), CDT1(1), DIAPH2(7), MCM10(6), MCM2(11), MCM3(10), MCM4(7), MCM5(4), MCM6(5), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), POLA2(9), POLD1(6), POLD2(2), POLD3(4), POLE(16), POLE2(3), PRIM1(3), RFC1(7), RFC2(3), RFC3(1), RPA1(3), RPA2(2), RPA3(1), RPA4(2), RPS27A(2), UBB(1), UBC(6) 19630574 141 86 138 88 85 9 6 24 17 0 0.944 1.000 1.000 333 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(3), EIF4A1(3), EIF4A2(4), EIF4B(4), EIF4E(1), EIF4EBP1(1), EIF4G1(14), EIF4G2(5), EIF4G3(17), FKBP1A(2), MKNK1(5), PDK2(4), PDPK1(4), PIK3CA(9), PIK3R1(7), PPP2CA(1), PTEN(23), RPS6(1), RPS6KB1(2), TSC1(5), TSC2(12) 10727435 127 86 121 43 55 11 13 16 30 2 0.115 1.000 1.000 334 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(10), CCR2(17), CCR3(11), CCR4(8), CCR5(7), CCR7(3), CD28(1), CD4(6), CSF2(2), CXCR3(5), CXCR4(4), IFNG(2), IFNGR1(4), IFNGR2(4), IL12A(3), IL12B(4), IL12RB1(17), IL12RB2(3), IL18R1(17), IL2(4), IL4(1), IL4R(14), IL5(4), TGFB1(1), TGFB2(1), TGFB3(3) 7738919 156 86 149 85 112 13 1 15 15 0 0.0637 1.000 1.000 335 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(9), ALDH4A1(6), ALDH5A1(11), CAD(18), CPS1(22), EPRS(11), GAD1(15), GAD2(10), GCLC(5), GCLM(2), GFPT1(4), GLS(2), GLS2(3), GLUD1(2), GLUL(2), GMPS(6), GOT1(6), GOT2(7), GPT(3), GPT2(1), GSS(7), NADSYN1(4), QARS(6) 12887254 162 85 155 75 96 17 10 26 13 0 0.167 1.000 1.000 336 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(2), ALDOB(13), ALDOC(3), FBP1(2), FBP2(2), GOT1(6), GOT2(7), GPT(3), GPT2(1), MDH1(1), MDH2(4), ME1(20), ME3(11), PGK1(5), PGK2(29), PKLR(11), PKM2(5), RPIA(1), TKT(6), TKTL1(2), TKTL2(29) 7854047 163 85 150 85 118 15 5 15 10 0 0.0362 1.000 1.000 337 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(5), BAIAP2(7), CASP1(5), CASP3(2), CASP7(5), CASP8(9), GAPDH(3), INSR(22), ITCH(8), MAGI1(28), MAGI2(29), RERE(21), WWP1(3), WWP2(7) 9342211 154 85 150 70 104 10 3 23 13 1 0.380 1.000 1.000 338 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(5), ESR2(8), ITPKA(1), PDE1A(37), PDE1B(13), PLCB1(52), PLCB2(10), PRL(1), TRH(4), VIP(5) 4264127 136 85 121 59 108 4 3 13 8 0 0.0154 1.000 1.000 339 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(11), AGT(6), AGTR2(12), EDN1(9), EDNRA(9), EDNRB(5), EGF(19), EGFR(23), FOS(2), HRAS(4), JUN(1), MYC(5), NFKB1(7), PLCG1(9), PRKCA(11), RELA(5) 7959700 138 84 134 75 98 11 7 15 7 0 0.433 1.000 1.000 340 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(11), CSF1R(13), DDX20(8), E2F1(7), E2F4(1), ETS1(5), ETS2(9), ETV3(4), FOS(2), HDAC2(1), HDAC5(7), HRAS(4), JUN(1), NCOR2(26), RBL1(11), RBL2(6), SIN3A(12), SIN3B(7) 10063602 135 84 135 63 87 9 3 24 12 0 0.161 1.000 1.000 341 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(12), ARHGEF1(1), GNA12(3), GNA13(1), GNAQ(5), MYL2(5), MYLK(41), PLCB1(52), PPP1R12B(8), PRKCA(11), ROCK1(5) 8060574 144 84 131 71 111 4 6 15 8 0 0.328 1.000 1.000 342 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(16), ABP1(20), AOC2(8), AOC3(8), CES1(16), CES7(14), DDHD1(7), ESCO1(2), ESCO2(3), LIPA(4), MYST3(16), MYST4(16), NAT6(2), PLA1A(9), PNPLA3(2), PPME1(1), PRDX6(4), SH3GLB1(2) 9840541 150 83 145 85 107 8 10 13 12 0 0.806 1.000 1.000 343 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(3), AKT2(8), AKT3(4), BCL2(2), GRB2(2), GSK3B(2), IL4R(14), IRS1(6), IRS2(2), JAK1(6), JAK3(7), MAP4K1(9), MAPK1(4), MAPK3(1), PDK1(2), PIK3CA(9), PIK3CD(7), PIK3R1(7), PPP1R13B(8), RAF1(8), SHC1(3), SOS1(9), SOS2(13), STAT6(8) 14154973 144 83 143 56 78 17 7 24 17 1 0.0737 1.000 1.000 344 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(6), CHAT(15), COMT(3), DBH(14), DDC(12), GAD1(15), GAD2(10), HDC(22), MAOA(4), PAH(9), PNMT(4), SLC18A3(3), TH(9), TPH1(9) 5473900 136 82 130 78 109 10 4 5 8 0 0.116 1.000 1.000 345 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(3), APAF1(6), ATM(13), BAX(3), BCL2(2), CASP3(2), CASP7(5), CASP9(3), CYCS(1), EIF2S1(1), PRKCA(11), PTK2(8), PXN(3), STAT1(4), TLN1(14), TP53(43) 10589263 122 82 111 42 61 11 9 16 25 0 0.0321 1.000 1.000 346 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(1), ARSD(3), ARSE(5), GAL3ST1(9), GALC(4), GBA(5), GLA(1), GLB1(8), LCT(43), NEU1(7), NEU2(14), NEU3(3), NEU4(9), PPAP2B(9), PPAP2C(8), SMPD1(3), SMPD2(2), SPTLC1(1), SPTLC2(6), UGCG(2) 9284804 143 82 135 88 101 13 2 18 9 0 0.734 1.000 1.000 347 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(8), ALDOA(2), ALDOB(13), ALDOC(3), FBP1(2), FBP2(2), FPGT(2), FUK(3), GMDS(5), GMPPA(2), GMPPB(3), HK1(3), HK2(12), HK3(15), HSD3B7(3), KHK(1), LHPP(1), MPI(1), MTMR1(4), MTMR2(3), MTMR6(2), PFKFB1(4), PFKFB2(6), PFKFB3(2), PFKFB4(5), PFKL(4), PFKM(2), PGM2(7), PMM1(2), PMM2(1), RDH11(2), RDH12(2), RDH13(3), SORD(2), TSTA3(2) 14304259 136 82 132 95 92 15 10 12 7 0 0.651 1.000 1.000 348 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(41), ABCB11(46), ABCB4(19), ABCC1(12), ABCC3(28), GSTP1(2) 5514338 148 82 140 75 100 15 5 12 16 0 0.00841 1.000 1.000 349 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(22), AXIN1(11), BTRC(5), CCND1(1), CREBBP(23), CSNK1A1(3), CSNK1D(1), CSNK2A1(1), CTNNB1(13), FZD1(4), GSK3B(2), HDAC1(1), MAP3K7(1), MYC(5), NLK(6), PPARD(3), PPP2CA(1), TLE1(5), WIF1(8), WNT1(2) 11315880 118 82 117 59 61 7 10 19 21 0 0.792 1.000 1.000 350 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(18), G6PD(4), GCLC(5), GCLM(2), GGT1(7), GPX1(3), GPX3(3), GPX5(13), GPX6(16), GSR(3), GSS(7), GSTA1(5), GSTA2(2), GSTA3(1), GSTA5(3), GSTK1(2), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTP1(2), GSTT1(1), IDH1(15), IDH2(2), MGST1(2), MGST2(2), MGST3(1), OPLAH(10), TXNDC12(1) 8469081 146 81 131 77 104 8 7 19 8 0 0.0666 1.000 1.000 351 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(6), ICAM1(3), ITGA4(38), ITGAL(24), ITGB1(4), ITGB2(14), SELE(36), SELL(8) 4649501 133 81 129 40 97 4 5 9 18 0 0.00154 1.000 1.000 352 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(2), CREBBP(23), EP300(14), IKBKB(4), IL1B(7), IL8(1), MAP2K3(9), MAP2K6(3), MAP3K14(4), MAP3K7(1), MAPK11(1), MAPK14(5), MYD88(3), NFKB1(7), NFKBIA(2), NR3C1(7), RELA(5), TGFBR2(7), TLR2(17), TNF(1) 11516979 123 81 122 70 72 16 6 21 8 0 0.897 1.000 1.000 353 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(41), AKT1(3), ATM(13), BAX(3), CDKN1A(4), CPB2(1), CSNK1A1(3), CSNK1D(1), HIC1(1), HIF1A(5), IGFBP3(2), MAPK8(2), MDM2(4), NFKBIB(1), NQO1(1), TP53(43) 8067850 128 81 113 46 67 9 8 18 26 0 0.109 1.000 1.000 354 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(5), ACTN1(5), ACTN2(24), ACTN3(7), CAPN1(4), CAPNS1(1), ITGA1(18), ITGB1(4), ITGB3(12), PTK2(8), PXN(3), RAC1(17), SPTAN1(8), SRC(1), TLN1(14) 10915877 131 81 118 67 88 9 5 14 14 1 0.0686 1.000 1.000 355 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(4), CSNK1D(1), DRD1(11), DRD2(17), GRM1(17), PLCB1(52), PPP1CA(2), PPP1R1B(2), PPP2CA(1), PPP3CA(5), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5) 6177258 135 80 128 85 100 5 7 12 11 0 0.626 1.000 1.000 356 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPAT6(3), AGPS(5), CHPT1(1), ENPP2(2), ENPP6(11), PAFAH1B1(4), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(2), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(7), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), PLD1(12), PLD2(7), PPAP2B(9), PPAP2C(8) 9045845 149 80 142 81 96 11 5 20 17 0 0.493 1.000 1.000 357 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(5), ADCY1(29), CAP1(1), CDC25C(5), GNAI1(1), GNAS(22), HRAS(4), MAPK1(4), MAPK3(1), MYT1(22), PIN1(1), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RPS6KA1(9), SRC(1) 7940787 128 80 123 90 91 9 5 9 14 0 0.880 1.000 1.000 358 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), ERCC3(5), GTF2A2(1), GTF2B(3), GTF2E1(2), GTF2E2(5), GTF2F2(2), GTF2H1(3), GTF2H4(2), MNAT1(2), POLR1A(11), POLR1B(9), POLR2A(12), POLR2B(11), POLR2C(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR3B(15), POLR3D(1), POLR3E(5), POLR3H(2), POLR3K(1), TAF13(2), TAF6(4), TAF7(2), TAF9(2), TBP(4) 13633174 116 80 114 50 69 10 9 19 9 0 0.250 1.000 1.000 359 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(1), FOS(2), GRB2(2), HRAS(4), JAK2(9), JUN(1), MAP2K1(13), MAPK3(1), MPL(8), PIK3CA(9), PIK3R1(7), PLCG1(9), PRKCA(11), RAF1(8), RASA1(4), SHC1(3), SOS1(9), STAT1(4), STAT3(11), STAT5A(3), STAT5B(4), THPO(8) 11584552 131 80 121 55 71 12 9 25 13 1 0.376 1.000 1.000 360 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(2), ALDOB(13), ALDOC(3), DERA(2), FBP1(2), FBP2(2), G6PD(4), GPI(3), H6PD(7), PFKL(4), PFKM(2), PGD(8), PGLS(1), PGM1(4), PGM3(4), PRPS1(2), PRPS1L1(14), PRPS2(4), RBKS(4), RPIA(1), TALDO1(3), TKT(6), TKTL1(2), TKTL2(29) 9391853 126 79 120 78 82 13 5 12 14 0 0.357 1.000 1.000 361 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(13), CDC25A(8), CDC25B(6), CDC25C(5), CDK4(5), CHEK1(2), MYT1(22), RB1(8), TP53(43), WEE1(3) 6827771 115 79 103 33 54 7 7 17 28 2 0.0214 1.000 1.000 362 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM2(1), CHUK(2), EGR2(4), EGR3(2), GNAQ(5), MAP3K1(3), MYC(5), NFATC1(15), NFATC2(9), NFKB1(7), NFKBIA(2), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RELA(5), SYT1(20), VIP(5), VIPR2(5) 10807472 134 79 130 87 89 11 7 16 11 0 0.944 1.000 1.000 363 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(35), AGT(6), AGTR1(11), AGTR2(12), BDKRB2(10), KNG1(14), NOS3(17), REN(9) 3832959 114 78 106 69 79 7 6 12 10 0 0.194 1.000 1.000 364 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(3), BCL2(2), BCR(11), CRKL(2), FOS(2), GRB2(2), HRAS(4), JAK2(9), JUN(1), MAP2K1(13), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(2), MYC(5), PIK3CA(9), PIK3R1(7), RAF1(8), SOS1(9), STAT1(4), STAT5A(3), STAT5B(4) 10839868 108 78 99 46 56 9 7 21 14 1 0.405 1.000 1.000 365 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(3), EIF2B5(1), EIF2S1(1), EIF4E(1), EIF4EBP1(1), GSK3B(2), IGF1(11), IGF1R(11), INPPL1(15), PDK2(4), PDPK1(4), PIK3CA(9), PIK3R1(7), PPP2CA(1), PTEN(23), RPS6(1), RPS6KB1(2) 7612850 97 78 91 37 43 8 10 12 23 1 0.276 1.000 1.000 366 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(4), GALNT10(6), GALNT2(6), GALNT3(3), GALNT4(6), GALNT6(17), GALNT7(5), GALNT8(24), GALNT9(5), GCNT1(7), ST3GAL1(6), ST3GAL2(1), ST3GAL4(1), WBSCR17(39) 5619136 130 78 122 61 98 8 5 9 10 0 0.117 1.000 1.000 367 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(3), CASP9(3), CDC42(3), CHUK(2), ELK1(2), H2AFX(2), HRAS(4), MAP2K1(13), MAPK3(1), NFKB1(7), PIK3CA(9), PIK3R1(7), RAC1(17), RAF1(8), RALA(1), RALBP1(2), RALGDS(8), RELA(5), RHOA(1) 7319844 98 78 80 44 58 10 3 19 7 1 0.330 1.000 1.000 368 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(4), DAB1(42), FYN(7), LRP8(3), RELN(76), VLDLR(5) 5420606 137 78 130 73 98 7 4 12 16 0 0.813 1.000 1.000 369 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(19), EGFR(23), MAP2K1(13), MAP3K1(3), MAPK14(5), NCOR2(26), RARA(3), RXRA(4), THRA(4), THRB(17) 6645093 117 77 109 59 82 9 5 14 7 0 0.386 1.000 1.000 370 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(3), CHIA(9), CHIT1(13), CMAS(2), CTBS(6), CYB5R1(1), GFPT1(4), GFPT2(5), GNE(3), GNPDA2(1), HEXA(7), HEXB(4), HK1(3), HK2(12), HK3(15), LHPP(1), MTMR1(4), MTMR2(3), MTMR6(2), NAGK(1), NANS(1), PGM3(4), RENBP(3), UAP1(2) 11106248 109 77 107 63 70 9 6 14 10 0 0.637 1.000 1.000 371 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(29), ADRB2(2), GNAS(22), PLCE1(53), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5) 5657622 129 77 122 74 89 9 7 13 11 0 0.614 1.000 1.000 372 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(3), CCND1(1), CCNE1(4), CDK4(5), CDK6(3), CDKN1A(4), CDKN1B(1), E2F1(7), HRAS(4), MAPK1(4), MAPK3(1), NFKB1(7), NFKBIA(2), PAK1(4), PIK3CA(9), PIK3R1(7), RAC1(17), RAF1(8), RB1(8), RELA(5), TFDP1(3) 7808329 107 77 96 40 54 7 7 21 15 3 0.0879 1.000 1.000 373 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(9), AKR1D1(20), CYP11A1(15), CYP11B1(16), CYP11B2(14), CYP17A1(7), CYP21A2(15), HSD11B1(11), HSD11B2(2), HSD3B1(10), HSD3B2(11) 3787288 130 76 118 62 90 11 5 13 11 0 0.00331 1.000 1.000 374 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(2), AKT1(3), ANXA1(4), CALM1(1), CALM2(1), GNAS(22), NFKB1(7), NOS3(17), NPPA(3), NR3C1(7), PIK3CA(9), PIK3R1(7), RELA(5), SYT1(20) 6887561 108 76 101 64 77 6 3 15 6 1 0.886 1.000 1.000 375 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(18), G6PD(4), GCLC(5), GCLM(2), GGT1(7), GPX1(3), GPX3(3), GPX5(13), GSS(7), GSTA1(5), GSTA2(2), GSTA3(1), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTP1(2), GSTT1(1), IDH1(15), IDH2(2), MGST1(2), MGST2(2), MGST3(1), PGD(8) 7000641 119 76 105 52 82 6 7 17 7 0 0.0115 1.000 1.000 376 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(9), AKR1D1(20), CYP11A1(15), CYP11B1(16), CYP11B2(14), CYP17A1(7), CYP21A2(15), HSD11B1(11), HSD11B2(2), HSD3B1(10), HSD3B2(11) 3787288 130 76 118 62 90 11 5 13 11 0 0.00331 1.000 1.000 377 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(24), PGAP1(5), PIGA(3), PIGB(4), PIGC(3), PIGF(2), PIGG(10), PIGH(1), PIGK(6), PIGL(2), PIGM(2), PIGN(4), PIGO(13), PIGQ(8), PIGS(1), PIGT(1), PIGU(7), PIGV(7), PIGW(2), PIGX(2), PIGZ(3) 9277664 111 76 109 49 63 9 8 21 10 0 0.115 1.000 1.000 378 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(4), IL2(4), IL2RA(4), IL2RB(7), IL2RG(3), JAK1(6), JAK3(7), JUN(1), LCK(14), MAP2K1(13), MAPK3(1), MAPK8(2), RAF1(8), SHC1(3), SOS1(9), STAT5A(3), STAT5B(4), SYK(16) 8918975 116 76 106 49 72 10 7 18 9 0 0.112 1.000 1.000 379 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CALM2(1), CAMK1(5), CAMK1G(11), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CAMK4(12), ESRRA(3), HDAC5(7), MEF2A(5), MEF2B(3), MEF2C(3), MEF2D(5), PPARA(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), SLC2A4(8), SYT1(20) 7773686 124 76 116 75 91 7 3 13 10 0 0.582 1.000 1.000 380 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(3), BAG4(4), CASP2(1), CASP3(2), CASP8(9), CRADD(1), DFFA(2), DFFB(3), JUN(1), LMNA(9), LMNB1(2), LMNB2(4), MADD(15), MAP2K4(4), MAP3K1(3), MAP3K7(1), MAPK8(2), PAK1(4), PAK2(8), PRKDC(20), RB1(8), RIPK1(1), SPTAN1(8), TNF(1), TNFRSF1A(3), TRAF2(3) 15099110 122 76 119 58 57 13 9 25 16 2 0.519 1.000 1.000 381 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(29), ADRB2(2), CFTR(46), GNAS(22), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), SLC9A3R1(3) 5015219 125 75 117 84 87 8 6 10 14 0 0.869 1.000 1.000 382 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(23), DAXX(10), HRAS(4), PAX3(4), PML(3), RARA(3), RB1(8), SP100(10), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TP53(43) 7292160 115 75 106 35 51 10 11 16 25 2 0.0137 1.000 1.000 383 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GALNS(4), GLB1(8), GNS(2), GUSB(4), HEXA(7), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(4), HYAL1(2), HYAL2(1), IDS(9), IDUA(4), LCT(43), NAGLU(4), SPAM1(23) 7878999 135 74 128 77 102 7 2 12 12 0 0.508 1.000 1.000 384 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(4), IGF1(11), IGF1R(11), IRS1(6), JUN(1), MAP2K1(13), MAPK3(1), MAPK8(2), PIK3CA(9), PIK3R1(7), PTPN11(10), RAF1(8), RASA1(4), SHC1(3), SOS1(9), SRF(2) 9601251 108 74 96 44 53 16 4 22 12 1 0.385 1.000 1.000 385 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(3), PIK3CA(9), PIK3R1(7), PLCB1(52), PLCG1(9), PRKCA(11), VAV1(16) 4987502 107 74 100 55 80 3 4 10 9 1 0.422 1.000 1.000 386 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(5), DYRK1B(2), GLI2(38), GLI3(17), GSK3B(2), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), SHH(5), SMO(11), SUFU(3) 6424837 106 74 103 60 70 12 7 8 9 0 0.511 1.000 1.000 387 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(5), EPHA4(19), EPHB1(27), FYN(7), ITGA1(18), ITGB1(4), L1CAM(9), LYN(7), RAP1B(1), SELP(31) 6119862 128 73 117 71 93 5 2 17 11 0 0.588 1.000 1.000 388 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(4), INSR(22), IRS1(6), JUN(1), MAP2K1(13), MAPK3(1), MAPK8(2), PIK3CA(9), PIK3R1(7), PTPN11(10), RAF1(8), RASA1(4), SHC1(3), SLC2A4(8), SOS1(9), SRF(2) 9927212 116 73 105 49 53 14 5 29 14 1 0.493 1.000 1.000 389 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(5), CS(2), DLAT(2), DLD(2), FH(3), IDH2(2), IDH3A(3), IDH3B(1), IDH3G(2), MDH1(1), MDH2(4), OGDH(11), PC(13), PDHA1(3), PDHA2(19), PDHB(1), PDHX(2), PDK1(2), PDK2(4), PDK3(4), PDK4(9), PDP2(6), SDHA(3), SDHB(1), SDHC(3), SDHD(1), SUCLG1(2), SUCLG2(2) 11039106 113 73 108 55 76 7 6 12 12 0 0.283 1.000 1.000 390 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(7), GBA3(14), LPO(18), MPO(11), PRDX1(2), PRDX2(2), PRDX6(4), TPO(45), TYR(8) 3747383 111 73 105 58 87 9 1 5 9 0 0.118 1.000 1.000 391 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(29), GNAS(22), PPP2CA(1), PRKAA1(1), PRKAA2(26), PRKAB1(2), PRKAB2(2), PRKACB(4), PRKACG(8), PRKAG1(2), PRKAG2(9), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5) 5916203 117 72 109 67 84 9 7 4 13 0 0.660 1.000 1.000 392 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(3), MAP2K1(13), MAP2K2(4), MAP2K3(9), MAP2K6(3), MAP3K1(3), MAPK1(4), MAPK14(5), MAPK3(1), NFKB1(7), PIK3CA(9), PIK3R1(7), RB1(8), RELA(5), SP1(5) 7496657 86 72 76 42 41 8 5 14 15 3 0.730 1.000 1.000 393 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(5), CARM1(6), CBS(7), CTH(1), GGT1(7), HEMK1(5), LCMT1(4), MARS(6), MARS2(4), MAT1A(5), MAT2B(3), METTL2B(8), METTL6(3), PAPSS1(3), PAPSS2(5), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), SCLY(3), SEPHS1(4), SEPHS2(2), WBSCR22(1) 9726533 106 72 104 48 65 11 5 17 8 0 0.108 1.000 1.000 394 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(5), ACTR2(3), ACTR3(2), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), NCK1(1), NCKAP1(7), NTRK1(19), PIR(1), RAC1(17), WASF1(5), WASF2(5), WASF3(12), WASL(5) 5939608 89 71 79 29 60 8 2 11 8 0 0.0685 1.000 1.000 395 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(8), GABRA1(16), GABRA2(16), GABRA3(19), GABRA4(13), GABRA5(3), GABRA6(24), GPHN(9), NSF(1), SRC(1), UBQLN1(6) 4552114 116 71 104 60 88 4 5 11 7 1 0.305 1.000 1.000 396 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(12), CYP2A13(12), CYP2A6(12), CYP2A7(8), NAT1(2), NAT2(10), XDH(56) 3117366 112 71 106 67 89 5 8 5 5 0 0.0583 1.000 1.000 397 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(7), CD3D(5), CD3E(2), CD3G(1), CXCR3(5), ETV5(7), IFNG(2), IL12A(3), IL12B(4), IL12RB1(17), IL12RB2(3), IL18(2), IL18R1(17), JAK2(9), JUN(1), MAP2K6(3), MAPK14(5), MAPK8(2), STAT4(22), TYK2(8) 7194305 125 71 122 65 86 9 4 15 11 0 0.552 1.000 1.000 398 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(11), APOA1(2), APOA4(8), APOC1(2), APOC2(1), APOE(1), CETP(7), CYP7A1(9), DGAT1(1), HMGCR(18), LDLR(16), LIPC(9), LPL(3), LRP1(40), SCARB1(5), SOAT1(3) 10719027 136 71 127 69 79 14 7 22 14 0 0.187 1.000 1.000 399 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(22), CDH1(7), CREBBP(23), EP300(14), MAP2K1(13), MAP3K7(1), MAPK3(1), SKIL(2), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(7) 9980763 95 71 87 44 57 8 3 15 12 0 0.776 1.000 1.000 400 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(2), ASNS(9), ASRGL1(3), CA1(10), CA12(3), CA13(5), CA2(10), CA3(5), CA4(4), CA5A(2), CA5B(1), CA6(4), CA7(2), CA8(4), CA9(8), CPS1(22), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(2), HAL(12) 8172092 120 70 118 53 81 10 4 14 11 0 0.125 1.000 1.000 401 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(2), IKBKB(4), IL1A(4), IL1R1(12), IRAK1(5), MAP3K1(3), MAP3K14(4), MAP3K7(1), MYD88(3), NFKB1(7), NFKBIA(2), RELA(5), RIPK1(1), TLR4(34), TNF(1), TNFAIP3(2), TNFRSF1A(3), TNFRSF1B(3), TRAF6(5) 9295489 101 70 98 62 68 10 5 10 8 0 0.814 1.000 1.000 402 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(5), GTF2A1(2), GTF2B(3), GTF2E1(2), GTF2F1(5), HDAC3(6), NCOA1(10), NCOA2(13), NCOA3(17), NCOR2(26), POLR2A(12), RARA(3), RXRA(4), TBP(4) 9627497 112 70 110 48 84 4 5 11 8 0 0.132 1.000 1.000 403 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(35), CD44(6), CSF1(11), FCGR3A(9), IL1B(7), IL6R(4), SELL(8), SPN(6), TGFB1(1), TGFB2(1), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TNFRSF8(20), TNFSF8(4) 5015941 119 70 113 51 87 6 6 6 14 0 0.0270 1.000 1.000 404 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(3), AKT2(8), AKT3(4), GRB2(2), MAPK1(4), MAPK3(1), PDK1(2), PIK3CA(9), PIK3CD(7), PTEN(23), PTK2B(11), RBL2(6), SHC1(3), SOS1(9) 7955283 92 70 88 35 39 7 6 19 21 0 0.362 1.000 1.000 405 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(2), ALDOB(13), ALDOC(3), FBP1(2), FBP2(2), FPGT(2), GCK(20), GMDS(5), GMPPA(2), GMPPB(3), HK1(3), HK2(12), HK3(15), KHK(1), MPI(1), PFKFB1(4), PFKFB3(2), PFKFB4(5), PFKM(2), PMM1(2), PMM2(1), SORD(2) 9228871 106 69 101 76 76 15 6 4 5 0 0.497 1.000 1.000 406 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(24), BST1(1), CD38(4), ENPP1(13), ENPP3(15), NADK(4), NADSYN1(4), NMNAT2(3), NMNAT3(8), NNMT(9), NNT(3), NT5C1A(3), NT5C1B(24), NT5C2(3), NT5C3(2), NT5E(4), NT5M(2), NUDT12(1), QPRT(6) 8358721 133 69 128 71 86 12 7 13 15 0 0.524 1.000 1.000 407 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(7), GBA(5), GBA3(14), LPO(18), MPO(11), PRDX6(4), TPO(45) 3253090 104 69 98 55 82 8 1 6 7 0 0.0832 1.000 1.000 408 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CALM2(1), CDKN1A(4), GNAQ(5), MARCKS(1), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(11), SP1(5), SP3(1), SYT1(20) 8112212 115 68 110 55 77 10 6 12 10 0 0.410 1.000 1.000 409 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(5), ACTN2(24), ACTN3(7), BCAR1(5), CSK(1), CTNNA1(2), CTNNA2(27), CTNNB1(13), PTK2(8), PXN(3), SRC(1), VCL(7) 7315183 103 68 98 56 65 7 5 13 12 1 0.247 1.000 1.000 410 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(5), ALOX15(9), ALOX15B(10), ALOX5(9), ALOX5AP(1), DPEP1(5), GGT1(7), LTA4H(4), PLA2G2A(2), PLA2G6(11), PTGDS(2), PTGIS(12), PTGS1(17), PTGS2(11), TBXAS1(14) 5783075 119 68 114 73 85 10 2 12 10 0 0.194 1.000 1.000 411 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(11), BCAT2(2), IARS(8), IARS2(14), ILVBL(4), LARS(10), LARS2(5), PDHA1(3), PDHA2(19), PDHB(1), VARS(18), VARS2(6) 7323207 101 68 89 42 66 11 3 12 9 0 0.145 1.000 1.000 412 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(4), FUCA1(3), GLB1(8), HEXA(7), HEXB(4), LCT(43), MAN2B1(7), MAN2B2(8), MAN2C1(3), MANBA(7), NEU1(7), NEU2(14), NEU3(3), NEU4(9) 7858351 127 68 122 64 96 11 3 12 5 0 0.179 1.000 1.000 413 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(3), BCAR1(5), CDKN1B(1), GRB2(2), ITGB1(4), MAPK1(4), MAPK3(1), PDK2(4), PDPK1(4), PIK3CA(9), PIK3R1(7), PTEN(23), PTK2(8), SHC1(3), SOS1(9) 7427491 87 68 82 32 38 5 6 15 22 1 0.439 1.000 1.000 414 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(6), CARS(10), DARS(4), EPRS(11), FARS2(5), GARS(6), HARS(6), IARS(8), KARS(6), LARS(10), LARS2(5), MARS(6), MARS2(4), NARS(2), QARS(6), RARS(7), SARS(10), TARS(2), WARS(4), WARS2(4), YARS(1) 12508890 123 67 116 54 77 12 7 17 10 0 0.220 1.000 1.000 415 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(10), CARS2(2), CDO1(6), CTH(1), GOT1(6), GOT2(7), LDHA(6), LDHAL6A(5), LDHAL6B(7), LDHB(2), LDHC(5), MPST(2), SDS(2), SULT1B1(11), SULT1C2(6), SULT1C4(12), SULT4A1(9) 4876626 99 67 94 31 69 3 9 8 10 0 0.00242 1.000 1.000 416 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(1), ATG5(3), ATG7(8), BECN1(4), GABARAPL1(1), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(10), IFNA17(2), IFNA2(1), IFNA21(9), IFNA4(1), IFNA5(3), IFNA6(3), IFNA7(5), IFNA8(3), IFNG(2), PIK3C3(3), PIK3R4(7), PRKAA1(1), PRKAA2(26), ULK1(8), ULK2(7), ULK3(1) 8100530 119 67 113 64 85 8 6 14 6 0 0.474 1.000 1.000 417 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(18), FOS(2), GRB2(2), HRAS(4), IL3(3), IL3RA(8), JAK2(9), MAP2K1(13), MAPK3(1), PTPN6(3), RAF1(8), SHC1(3), SOS1(9), STAT5A(3), STAT5B(4) 6808795 90 67 82 42 53 4 5 16 12 0 0.404 1.000 1.000 418 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(4), IL6(2), IL6R(4), IL6ST(10), JAK1(6), JAK2(9), JAK3(7), JUN(1), MAP2K1(13), MAPK3(1), PTPN11(10), RAF1(8), SHC1(3), SOS1(9), SRF(2), STAT3(11) 9218757 107 67 97 46 50 13 5 27 12 0 0.510 1.000 1.000 419 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(21), CPT1A(11), LEP(2), LEPR(25), PRKAA1(1), PRKAA2(26), PRKAB1(2), PRKAB2(2), PRKAG1(2), PRKAG2(9) 5664436 101 67 93 53 72 6 4 6 13 0 0.654 1.000 1.000 420 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(2), ALDOB(13), ALDOC(3), FBP1(2), FBP2(2), G6PD(4), GPI(3), H6PD(7), PFKM(2), PGD(8), PGLS(1), PGM1(4), PGM3(4), PRPS1(2), PRPS1L1(14), PRPS2(4), RBKS(4), RPIA(1), TAL1(7), TALDO1(3), TKT(6) 7912863 96 67 93 63 61 8 5 10 12 0 0.570 1.000 1.000 421 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(13), ATR(25), CDC25C(5), CHEK1(2), CHEK2(2), TP53(43) 6210627 90 67 80 26 46 3 7 12 22 0 0.105 1.000 1.000 422 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(3), AP2A1(1), AP2M1(3), BTK(17), EEA1(4), GRASP(1), GSK3B(2), LYN(7), PDPK1(4), PFKL(4), PFKM(2), PLCG1(9), PRKCE(6), PRKCZ(6), RAB5A(1), RAC1(17), RPS6KB1(2), VAV2(4) 9583374 93 67 82 47 58 5 5 13 12 0 0.169 1.000 1.000 423 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(5), ACO2(5), CS(2), DLD(2), FH(3), IDH1(15), IDH2(2), IDH3A(3), IDH3B(1), IDH3G(2), MDH1(1), MDH2(4), PC(13), PCK1(23), SDHA(3), SDHB(1), SUCLG1(2), SUCLG2(2) 8044341 89 66 75 50 65 3 6 9 6 0 0.448 1.000 1.000 424 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CD3D(5), CD3E(2), CD3G(1), CD80(5), CD86(21), CTLA4(2), GRB2(2), HLA-DRA(11), HLA-DRB1(4), ICOS(3), IL2(4), ITK(21), LCK(14), PIK3CA(9), PIK3R1(7), PTPN11(10) 4957431 122 66 115 45 78 8 3 17 15 1 0.113 1.000 1.000 425 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(1), ERBB4(50), NRG2(7), NRG3(21), PRKCA(11), PSEN1(1) 3457779 91 66 82 34 70 4 2 6 9 0 0.0520 1.000 1.000 426 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(3), CAT(6), EPX(7), LPO(18), MPO(11), PRDX1(2), PRDX2(2), PRDX6(4), SHMT1(1), SHMT2(3), TPO(45) 4588990 102 66 98 56 80 9 1 7 5 0 0.132 1.000 1.000 427 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(6), ICAM1(3), ITGAL(24), ITGAM(21), ITGB2(14), SELE(36), SELL(8) 3980549 112 66 112 41 81 4 3 7 17 0 0.00336 1.000 1.000 428 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(2), ASNS(9), CA1(10), CA12(3), CA2(10), CA3(5), CA4(4), CA5A(2), CA5B(1), CA6(4), CA7(2), CA8(4), CA9(8), CPS1(22), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUL(2), HAL(12) 7306567 108 66 106 47 73 8 3 14 10 0 0.123 1.000 1.000 429 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(3), CNR1(9), CNR2(4), DNMT1(19), MTNR1A(8), MTNR1B(7), PTAFR(2), PTGDR(9), PTGER2(6), PTGER4(1), PTGFR(22), PTGIR(6), TBXA2R(4) 4322111 100 66 95 76 67 12 5 8 8 0 0.431 1.000 1.000 430 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(11), CALM1(1), CALM2(1), CAPN2(6), CAPNS1(1), EP300(14), HDAC1(1), HDAC2(1), MEF2D(5), NFATC1(15), NFATC2(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(11), SYT1(20) 9512402 107 65 102 55 75 7 7 10 8 0 0.539 1.000 1.000 431 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(7), CD2(23), CD3D(5), CD3E(2), CD3G(1), CD4(6), CXCR3(5), IFNG(2), IL12A(3), IL12B(4), IL12RB1(17), IL12RB2(3), JAK2(9), STAT4(22), TYK2(8) 5639582 117 65 111 61 77 12 4 13 11 0 0.349 1.000 1.000 432 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(6), BIRC2(5), BIRC3(8), CASP10(5), CASP3(2), CASP7(5), CASP8(9), CASP9(3), DFFA(2), DFFB(3), GZMB(3), PRF1(13), SCAP(8), SREBF1(5), SREBF2(10) 7059931 87 65 83 43 52 7 7 12 9 0 0.448 1.000 1.000 433 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(2), ALDOB(13), ALDOC(3), FBP1(2), FBP2(2), GOT1(6), GOT2(7), GPT(3), GPT2(1), MDH1(1), MDH2(4), ME1(20), ME2(1), ME3(11), PGK1(5), PKLR(11), PKM2(5), RPIA(1), TKT(6) 7017484 104 64 101 54 73 8 5 9 9 0 0.103 1.000 1.000 434 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(16), GABRA2(16), GABRA3(19), GABRA4(13), GABRA5(3), GABRA6(24), GPX1(3), PRKCE(6) 2997250 100 64 88 50 75 5 3 10 6 1 0.220 1.000 1.000 435 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(3), GSR(3), GSS(7), IL8(1), NFKB1(7), NOX1(11), RELA(5), TNF(1), XDH(56) 3828590 94 64 91 42 73 7 4 7 3 0 0.0383 1.000 1.000 436 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(5), BHMT(9), CBS(7), CTH(1), DNMT1(19), DNMT3A(6), DNMT3B(10), MARS(6), MARS2(4), MAT1A(5), MAT2B(3), MTAP(4), MTFMT(2), MTR(10), TAT(17) 8133778 108 64 104 45 70 6 8 14 10 0 0.0730 1.000 1.000 437 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(16), AP2A1(1), AP2M1(3), BIN1(5), CALM1(1), CALM2(1), DNM1(8), EPN1(6), EPS15(3), PICALM(1), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYNJ1(23), SYNJ2(16), SYT1(20) 8293541 115 64 110 57 82 10 2 16 5 0 0.388 1.000 1.000 438 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(9), PARK2(9), SNCA(2), SNCAIP(54), UBE2E2(4), UBE2F(5), UBE2G2(1), UBE2L6(2) 2499759 86 64 77 32 65 9 2 4 6 0 0.0471 1.000 1.000 439 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(3), GRB2(2), HRAS(4), IGF1R(11), IRS1(6), MAP2K1(13), MAPK1(4), MAPK3(1), PIK3CA(9), PIK3R1(7), RAF1(8), SHC1(3), SOS1(9) 7379970 80 63 71 32 42 8 4 14 11 1 0.289 1.000 1.000 440 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(3), CAT(6), GH1(3), GHR(30), HRAS(4), IGF1(11), IGF1R(11), PIK3CA(9), PIK3R1(7), SHC1(3) 5148532 87 63 82 41 58 9 2 9 8 1 0.326 1.000 1.000 441 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(4), FUCA1(3), GLB1(8), HEXA(7), HEXB(4), LCT(43), MAN2C1(3), MANBA(7), NEU1(7), NEU2(14), NEU3(3), NEU4(9) 6378613 112 63 107 57 85 9 2 11 5 0 0.307 1.000 1.000 442 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(21), HLA-DRA(11), HLA-DRB1(4), IFNG(2), IFNGR1(4), IFNGR2(4), IL12A(3), IL12B(4), IL12RB1(17), IL12RB2(3), IL18(2), IL18R1(17), IL2(4), IL2RA(4), IL4(1), IL4R(14) 4908856 116 63 110 49 86 6 0 9 15 0 0.0758 1.000 1.000 443 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(3), CAT(6), EPX(7), LPO(18), MPO(11), MTHFR(1), PRDX6(4), SHMT1(1), SHMT2(3), TPO(45) 4532876 99 62 95 55 78 9 1 7 4 0 0.137 1.000 1.000 444 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(5), CASP2(1), CHUK(2), CRADD(1), IKBKB(4), JUN(1), LTA(2), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP3K1(3), MAP3K14(4), MAP4K2(6), MAPK14(5), MAPK8(2), NFKB1(7), NFKBIA(2), RELA(5), RIPK1(1), TNF(1), TNFRSF1A(3), TRAF2(3) 9217209 74 62 74 48 42 12 3 10 7 0 0.871 1.000 1.000 445 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(23), CD28(1), CD3D(5), CD3E(2), CD3G(1), CD8A(2), ICAM1(3), ITGAL(24), ITGB2(14), PTPRC(33), THY1(1) 4117912 109 62 101 48 78 7 2 7 15 0 0.0270 1.000 1.000 446 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(23), CD28(1), CD3D(5), CD3E(2), CD3G(1), CD4(6), ICAM1(3), ITGAL(24), ITGB2(14), PTPRC(33), THY1(1) 4316842 113 62 105 54 80 8 2 8 15 0 0.0599 1.000 1.000 447 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(3), CHRNB1(2), CHRNG(2), MUSK(33), PIK3CA(9), PIK3R1(7), PTK2(8), PTK2B(11), RAPSN(1), SRC(1), TERT(9) 6302245 86 61 82 67 53 7 2 15 8 1 0.959 1.000 1.000 448 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(6), ARHGDIB(3), BIRC2(5), BIRC3(8), CASP1(5), CASP10(5), CASP2(1), CASP3(2), CASP4(1), CASP7(5), CASP8(9), CASP9(3), CYCS(1), DFFA(2), DFFB(3), GZMB(3), LMNA(9), LMNB1(2), LMNB2(4), PRF1(13) 7588306 90 61 88 40 50 12 6 15 7 0 0.352 1.000 1.000 449 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(29), FHL5(13), FSHB(4), FSHR(19), GNAS(22), XPO1(2) 3669903 89 61 85 51 68 6 4 5 6 0 0.644 1.000 1.000 450 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), ELK1(2), EPO(6), EPOR(1), FOS(2), GRB2(2), HRAS(4), JAK2(9), JUN(1), MAP2K1(13), MAPK3(1), MAPK8(2), PLCG1(9), PTPN6(3), RAF1(8), SHC1(3), SOS1(9), STAT5A(3), STAT5B(4) 8261521 83 61 74 41 45 5 7 18 8 0 0.627 1.000 1.000 451 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(3), GRB2(2), HRAS(4), MAPK1(4), MAPK3(1), MAPK7(4), MEF2A(5), MEF2B(3), MEF2C(3), MEF2D(5), NTRK1(19), PIK3CA(9), PIK3R1(7), PLCG1(9), RPS6KA1(9), SHC1(3) 7324520 90 61 86 55 50 13 5 9 12 1 0.808 1.000 1.000 452 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(4), ALG5(2), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT5(3), DDOST(3), DPAGT1(2), DPM1(1), FUT8(8), MAN1A1(17), MAN1B1(4), MGAT1(3), MGAT2(3), MGAT3(10), MGAT4A(8), MGAT4B(1), MGAT5(5), RPN2(2), ST6GAL1(5) 7748008 88 61 86 55 54 10 4 10 10 0 0.702 1.000 1.000 453 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(1), DPM2(1), ELK1(2), FOS(2), GRB2(2), HRAS(4), JUN(1), KLK2(2), MAP2K1(13), MAPK3(1), MAPK8(2), NGFR(8), PIK3CA(9), PIK3R1(7), PLCG1(9), RAF1(8), SHC1(3), SOS1(9) 7376993 84 61 75 37 47 7 4 17 8 1 0.471 1.000 1.000 454 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(4), BIRC2(5), BIRC3(8), CASP3(2), CASP8(9), CFLAR(4), JUN(1), MAP2K4(4), MAP3K3(6), MAP3K7(1), NFKB1(7), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), NR2C2(2), RALBP1(2), RIPK1(1), TNF(1), TNFAIP3(2), TNFRSF1A(3), TNFRSF1B(3), TRAF2(3) 10477390 83 61 82 53 44 6 9 18 6 0 0.939 1.000 1.000 455 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(5), B3GNT1(2), B3GNT2(2), B3GNT3(6), B3GNT4(4), B3GNT5(1), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT4(3), FUT1(3), FUT2(3), FUT3(6), FUT4(2), FUT5(6), FUT6(4), FUT7(2), FUT9(25), ST3GAL6(2), ST8SIA1(1) 6180804 84 60 82 41 54 10 4 7 9 0 0.110 1.000 1.000 456 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(11), POLR1B(9), POLR1C(1), POLR2A(12), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(5), POLR3B(15), POLR3G(1), POLR3GL(1), POLR3H(2), POLR3K(1), ZNRD1(1) 9116270 80 60 79 36 45 8 7 12 8 0 0.310 1.000 1.000 457 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(5), NFKB1(7), NFKBIA(2), PLCB1(52), PRKCA(11), RELA(5) 3179308 82 60 76 30 62 3 3 9 5 0 0.0605 1.000 1.000 458 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(6), CREBBP(23), EP300(14), NCOA3(17), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RARA(3), RXRA(4) 8030342 90 59 90 46 56 5 4 15 10 0 0.764 1.000 1.000 459 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(5), CYSLTR2(4), GPR109B(8), GPR161(7), GPR171(9), GPR18(6), GPR34(2), GPR39(11), GPR45(6), GPR65(10), GPR68(3), GPR75(5), GPR81(5) 3792052 81 59 79 44 58 4 4 6 9 0 0.0147 1.000 1.000 460 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(3), BCL2(2), CASP8(9), CYCS(1), MAP2K1(13), MAP2K4(4), MAP3K1(3), MAPK1(4), MAPK3(1), MAPK8(2), NFKB1(7), NSMAF(4), RAF1(8), RELA(5), RIPK1(1), SMPD1(3), TNFRSF1A(3), TRAF2(3) 7902560 76 58 67 33 45 7 3 13 8 0 0.380 1.000 1.000 461 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(5), CD3E(2), CD3G(1), CD4(6), FYN(7), HLA-DRA(11), HLA-DRB1(4), LCK(14), PTPRC(33), ZAP70(7) 3427242 90 58 85 36 62 8 2 9 9 0 0.0494 1.000 1.000 462 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(3), CASP9(3), CHUK(2), GH1(3), GHR(30), NFKB1(7), NFKBIA(2), PDPK1(4), PIK3CA(9), PIK3R1(7), PPP2CA(1), RELA(5) 5425752 76 57 71 41 48 6 4 9 8 1 0.744 1.000 1.000 463 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(2), B4GALNT1(3), GLB1(8), HEXA(7), HEXB(4), LCT(43), SLC33A1(5), ST3GAL1(6), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(6), ST6GALNAC4(1), ST6GALNAC5(7), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(9) 6391362 107 57 102 67 77 9 1 14 6 0 0.625 1.000 1.000 464 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(1), ACOT11(9), DHRS1(3), DHRS2(7), DHRS3(4), DHRS7(1), DHRSX(4), ECHS1(2), EHHADH(7), ESCO1(2), ESCO2(3), GCDH(5), HADHA(8), ITGB1BP3(2), MYST3(16), MYST4(16), NAT6(2), PNPLA3(2), SH3GLB1(2), YOD1(1) 10128171 97 57 94 60 56 11 5 19 6 0 0.945 1.000 1.000 465 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(24), CD38(4), ENPP1(13), ENPP3(15), NADSYN1(4), NMNAT2(3), NNMT(9), NNT(3), NT5E(4), NT5M(2), QPRT(6) 5655090 87 57 82 41 54 10 5 9 9 0 0.314 1.000 1.000 466 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(1), APC(22), AXIN1(11), BTRC(5), CTNNB1(13), DLL1(4), FZD1(4), GSK3B(2), NOTCH1(5), PSEN1(1), WNT1(2) 8176380 70 57 70 40 35 7 5 8 15 0 0.840 1.000 1.000 467 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(6), POLD2(2), POLE(16), POLG(9), POLL(7), POLQ(25) 6483926 65 56 64 29 35 5 2 13 10 0 0.338 1.000 1.000 468 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(5), BHMT(9), CBS(7), CTH(1), DNMT1(19), DNMT3A(6), DNMT3B(10), MARS(6), MARS2(4), MAT1A(5), MAT2B(3), MTR(10) 6845986 85 56 82 31 54 4 7 12 8 0 0.0296 1.000 1.000 469 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(23), EP300(14), LPL(3), NCOA1(10), NCOA2(13), PPARG(11), RXRA(4) 7215398 78 56 76 31 52 4 3 12 7 0 0.406 1.000 1.000 470 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(5), GNAQ(5), HTR2C(12), PLCB1(52), TUB(9) 2771390 83 56 77 42 65 2 2 9 5 0 0.211 1.000 1.000 471 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(2), GCK(20), GFPT1(4), GNE(3), GNPDA2(1), HEXA(7), HEXB(4), HK1(3), HK2(12), HK3(15), PGM3(4), RENBP(3), UAP1(2) 6582743 80 55 77 44 53 7 3 9 8 0 0.464 1.000 1.000 472 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(21), ACACB(21), FASN(17), MCAT(2), OLAH(13), OXSM(2) 6119869 76 55 75 42 48 7 3 9 9 0 0.335 1.000 1.000 473 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(7), ACOX3(13), FADS2(4), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(7), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11) 3929120 88 55 85 48 64 5 1 7 11 0 0.264 1.000 1.000 474 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(2), ALDH18A1(7), ARG1(2), ARG2(1), ASL(6), CKM(2), CKMT1A(1), CKMT2(5), CPS1(22), GAMT(4), GATM(5), GLUD1(2), NAGS(1), OAT(3), ODC1(3), OTC(3), PYCR1(2), SMS(6) 6703986 77 55 75 33 44 9 4 10 10 0 0.149 1.000 1.000 475 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(5), CHUK(2), IFNG(2), IKBKB(4), IL2(4), IL4(1), JUN(1), MAP3K1(3), MAP3K5(18), MAP4K5(3), MAPK14(5), MAPK8(2), NFKB1(7), NFKBIA(2), RELA(5), TNFRSF9(4), TNFSF9(1), TRAF2(3) 7429779 72 54 69 36 44 6 1 12 9 0 0.622 1.000 1.000 476 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF2(2), CSF3(5), EPO(6), FLT3(31), IGF1(11), IL11(2), IL1A(4), IL3(3), IL6(2), IL9(1), KITLG(9), TGFB1(1), TGFB2(1), TGFB3(3) 3196428 81 54 74 35 54 7 4 10 6 0 0.0561 1.000 1.000 477 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(12), CYP11A1(15), CYP11B2(14), CYP17A1(7), HSD11B1(11), HSD11B2(2), HSD3B1(10), HSD3B2(11) 2675129 82 54 78 56 60 7 1 6 8 0 0.156 1.000 1.000 478 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(7), ASPH(3), COPS5(3), EDN1(9), EP300(14), EPO(6), HIF1A(5), JUN(1), LDHA(6), NOS3(17), P4HB(3), VHL(4) 6632912 78 54 75 35 48 4 5 10 11 0 0.533 1.000 1.000 479 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(42), CYP2C9(38) 783781 80 54 72 51 64 4 2 4 6 0 0.615 1.000 1.000 480 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(8), IL22(2), IL22RA1(12), IL22RA2(1), JAK1(6), JAK2(9), JAK3(7), SOCS3(2), STAT1(4), STAT3(11), STAT5A(3), STAT5B(4), TYK2(8) 7060911 77 54 77 44 39 8 7 16 7 0 0.721 1.000 1.000 481 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(6), CSF1(11), CSF2(2), CSF3(5), HLA-DRA(11), HLA-DRB1(4), IFNA1(1), IFNB1(6), IFNG(2), IL10(3), IL11(2), IL12A(3), IL12B(4), IL13(2), IL15(3), IL1A(4), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(5), IL8(1), LTA(2), PDGFA(1), TGFB1(1), TGFB2(1), TGFB3(3), TNF(1) 5099791 98 54 96 53 67 7 3 9 12 0 0.0637 1.000 1.000 482 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(4), ACADM(6), ACADS(4), ACADVL(1), ACSL1(6), ACSL3(6), ACSL4(2), CPT1A(11), CPT2(1), DCI(2), EHHADH(7), HADHA(8), PECR(1), SCP2(4), SLC25A20(1) 6587851 64 54 61 31 42 4 3 9 6 0 0.580 1.000 1.000 483 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(3), IL6(2), IL6R(4), JAK1(6), JAK2(9), JAK3(7), PIAS3(5), PTPRU(16), REG1A(8), SRC(1), STAT3(11) 5887613 72 54 72 41 39 7 3 12 11 0 0.577 1.000 1.000 484 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(3), DPM2(1), GRB2(2), HRAS(4), KLK2(2), NTRK1(19), PIK3CA(9), PIK3R1(7), PLCG1(9), PRKCA(11), SHC1(3), SOS1(9) 6031555 79 54 77 36 44 10 4 12 8 1 0.455 1.000 1.000 485 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(4), ARFGAP3(3), ARFGEF2(19), CLTA(1), CLTB(1), COPA(7), GBF1(12), GPLD1(24), KDELR3(2) 6360760 73 53 73 46 42 5 5 14 7 0 0.863 1.000 1.000 486 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM2(1), CAMK1(5), CAMK1G(11), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CAMK4(12), CAMKK1(3), CAMKK2(8), SYT1(20) 4506424 83 53 77 65 61 8 2 8 4 0 0.917 1.000 1.000 487 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM2(1), CCL2(1), CCR5(7), CXCL12(2), CXCR4(4), FOS(2), GNAQ(5), JUN(1), MAPK14(5), MAPK8(2), PLCG1(9), PRKCA(11), PTK2B(11), SYT1(20) 5365723 82 53 77 59 54 7 4 12 5 0 0.854 1.000 1.000 488 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(7), B3GAT2(2), B3GAT3(4), CHPF(4), CHST11(5), CHST12(4), CHST13(3), CHST14(3), CHST3(1), CHSY1(8), DSE(19), XYLT1(13), XYLT2(3) 5142169 76 53 76 50 50 11 3 8 4 0 0.457 1.000 1.000 489 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(6), ACOX1(7), ACOX3(13), ELOVL2(2), ELOVL5(1), ELOVL6(2), FADS2(4), FASN(17), HADHA(8), HSD17B12(2), PECR(1), SCD(3) 5535921 66 53 65 32 43 4 3 9 7 0 0.0977 1.000 1.000 490 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(6), DHRS1(3), DHRS2(7), DHRS3(4), DHRS7(1), DHRSX(4), HEMK1(5), LCMT1(4), METTL2B(8), METTL6(3), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), WBSCR22(1) 5849756 70 52 69 34 41 9 2 14 4 0 0.308 1.000 1.000 491 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(20), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C2(9), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), FDXR(8), SHMT1(1) 6225829 80 51 79 45 44 5 6 14 11 0 0.510 1.000 1.000 492 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(7), F13B(24), HSD17B2(10), HSD17B3(6), HSD17B4(6), HSD17B7(2), HSD3B1(10), HSD3B2(11) 3107701 76 51 70 32 54 5 5 4 7 1 0.0547 1.000 1.000 493 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(20), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C2(9), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), SHMT1(1) 5852197 72 50 71 41 39 4 6 13 10 0 0.570 1.000 1.000 494 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(20), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C2(9), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), SHMT1(1) 5852197 72 50 71 41 39 4 6 13 10 0 0.570 1.000 1.000 495 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH9A1(3), ECHS1(2), EHHADH(7), HADHA(8), SDS(2) 4703326 63 50 61 34 36 10 2 9 6 0 0.351 1.000 1.000 496 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(3), JAK1(6), JAK2(9), JAK3(7), PIAS1(5), PIAS3(5), PTPRU(16), REG1A(8), SOAT1(3) 5296375 62 50 62 29 38 5 2 8 9 0 0.294 1.000 1.000 497 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(20), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C2(9), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), SHMT1(1) 5852197 72 50 71 41 39 4 6 13 10 0 0.570 1.000 1.000 498 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(31), MAP2(13), PPP1CA(2), PPP2CA(1), PRKACB(4), PRKACG(8), PRKAG1(2), PRKAR2A(1), PRKAR2B(5), PRKCE(6) 7020342 73 49 71 44 44 7 5 8 9 0 0.939 1.000 1.000 499 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(6), CD3D(5), CD3E(2), CD3G(1), GZMB(3), HLA-A(3), ICAM1(3), ITGAL(24), ITGB2(14), PRF1(13) 3370721 74 49 73 31 45 7 1 6 15 0 0.0368 1.000 1.000 500 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(19), EGFR(23), ERBB3(6), NRG1(17), UBE2D1(1) 4011460 66 49 65 41 48 2 5 7 4 0 0.931 1.000 1.000 501 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(6), B3GALNT1(6), B3GALT5(1), FUT1(3), FUT2(3), FUT9(25), GBGT1(2), GLA(1), HEXA(7), HEXB(4), NAGA(4), ST3GAL1(6), ST3GAL2(1), ST8SIA1(1) 4165929 70 49 68 40 47 6 4 9 4 0 0.388 1.000 1.000 502 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(11), CD4(6), HLA-DRA(11), HLA-DRB1(4), IL1B(7), IL4(1), IL5(4), IL5RA(14), IL6(2) 2071557 61 49 58 34 46 2 1 5 7 0 0.149 1.000 1.000 503 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(5), CAMK1G(11), HDAC9(44), MEF2A(5), MEF2B(3), MEF2C(3), MEF2D(5), MYOD1(1) 2878500 77 49 67 33 60 6 0 4 7 0 0.119 1.000 1.000 504 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(2), CREBBP(23), EP300(14), HDAC3(6), IKBKB(4), NFKB1(7), NFKBIA(2), RELA(5), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF6(5) 8647792 76 49 76 38 45 7 5 13 6 0 0.654 1.000 1.000 505 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(2), MAP3K14(4), MAPK14(5), MAPK8(2), NFKB1(7), RELA(5), TNFRSF13B(8), TNFRSF17(6), TNFSF13B(1), TRAF2(3), TRAF3(5), TRAF5(7), TRAF6(5) 5574975 60 49 59 26 39 7 0 11 3 0 0.289 1.000 1.000 506 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(4), EGF(19), EGFR(23), HGS(4), RAB5A(1), TF(13), TFRC(5) 4980830 69 48 69 43 45 2 7 9 6 0 0.908 1.000 1.000 507 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), KHK(1), LCT(43), MPI(1), PGM1(4), PYGL(9), PYGM(10), TREH(3) 5119104 74 48 70 61 58 6 1 5 4 0 0.832 1.000 1.000 508 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GALNS(4), GLB1(8), GNS(2), GUSB(4), HEXA(7), HEXB(4), IDS(9), IDUA(4), LCT(43), NAGLU(4) 5544383 90 48 85 50 72 5 0 8 5 0 0.415 1.000 1.000 509 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), CYP51A1(1), DHCR24(1), DHCR7(10), FDPS(3), GGCX(4), GGPS1(1), HMGCR(18), HSD17B7(2), IDI1(1), IDI2(1), LSS(2), MVD(1), MVK(3), NQO1(1), NSDHL(3), PMVK(2), SC4MOL(3), SC5DL(2), SQLE(5), TM7SF2(5) 7475888 70 48 63 31 33 11 4 14 8 0 0.237 1.000 1.000 510 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(1), MRPS7(2), RPL10L(6), RPL11(2), RPL13A(2), RPL14(1), RPL18(3), RPL18A(1), RPL19(1), RPL21(1), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL36AL(1), RPL38(1), RPL39(1), RPL3L(3), RPL6(1), RPL7(2), RPS10(1), RPS11(1), RPS13(1), RPS16(1), RPS18(1), RPS2(2), RPS20(2), RPS23(1), RPS24(1), RPS27(1), RPS29(1), RPS3A(1), RPS4Y1(1), RPS5(2), RPS6(1), RPS7(4), RPS8(1), RPSA(2) 8738644 65 48 65 44 34 6 8 10 7 0 0.871 1.000 1.000 511 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(6), CLOCK(5), CRY1(7), CRY2(3), CSNK1D(1), CSNK1E(4), NPAS2(7), PER1(8), PER2(13), PER3(9) 6600024 63 48 60 43 40 7 2 4 10 0 0.937 1.000 1.000 512 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(13), CDC25A(8), CDC25B(6), CDC25C(5), CHEK1(2), MYT1(22), WEE1(3) 5347172 59 47 57 31 35 6 2 8 8 0 0.803 1.000 1.000 513 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(14), AMT(2), ATIC(5), FTCD(3), GART(10), MTFMT(2), MTHFD1(10), MTHFD1L(1), MTHFD2(2), MTHFR(1), MTR(10), SHMT1(1), SHMT2(3), TYMS(1) 7355030 65 47 64 41 41 7 3 7 7 0 0.819 1.000 1.000 514 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(5), APAF1(6), BCL2(2), CASP3(2), CASP9(3), CYCS(1), DAXX(10), FAS(5), FASLG(14), HSPB1(2), HSPB2(1), IL1A(4), MAPKAPK2(5), MAPKAPK3(4), TNF(1) 4417720 65 47 65 31 42 4 3 8 8 0 0.271 1.000 1.000 515 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(8), IL13(2), IL4(1), IL5(4), MAF(1), MAP2K3(9), MAPK14(5), NFATC1(15), NFATC2(9), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5) 4675585 77 46 75 48 51 8 4 5 9 0 0.595 1.000 1.000 516 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(6), CHPT1(1), HEMK1(5), LCMT1(4), METTL2B(8), METTL6(3), PCYT1A(3), PCYT1B(8), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), WBSCR22(1) 5451276 63 46 61 25 37 7 4 11 4 0 0.119 1.000 1.000 517 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(2), B3GNT2(2), B3GNT7(4), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT4(3), CHST1(9), CHST2(4), CHST4(11), CHST6(4), FUT8(8), ST3GAL1(6), ST3GAL2(1), ST3GAL3(2), ST3GAL4(1) 4823741 64 46 62 45 42 12 4 2 4 0 0.624 1.000 1.000 518 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(6), ARHGAP5(12), ARHGDIB(3), CASP1(5), CASP10(5), CASP3(2), CASP8(9), CASP9(3), CYCS(1), GZMB(3), JUN(1), PRF1(13) 5019978 63 45 60 32 41 6 3 9 4 0 0.666 1.000 1.000 519 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(6), FUT1(3), FUT2(3), FUT9(25), GBGT1(2), GLA(1), HEXA(7), HEXB(4), NAGA(4), ST3GAL1(6), ST3GAL2(1), ST3GAL4(1), ST8SIA1(1) 3922314 64 45 62 30 43 6 2 9 4 0 0.121 1.000 1.000 520 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNB1(6), JAK1(6), PTPRU(16), REG1A(8), STAT1(4), STAT2(8), TYK2(8) 4863039 58 45 58 31 30 5 2 10 11 0 0.461 1.000 1.000 521 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(14), AMT(2), ATIC(5), GART(10), MTHFD1(10), MTHFD1L(1), MTHFD2(2), MTHFR(1), MTR(10), SHMT1(1), SHMT2(3), TYMS(1) 6946441 60 44 59 36 37 7 3 7 6 0 0.724 1.000 1.000 522 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(3), GNAS(22), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(11) 3670577 59 43 57 41 46 4 2 2 5 0 0.934 1.000 1.000 523 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(20), AOC2(8), AOC3(8), CES1(16), ESD(2) 2334551 54 43 52 36 43 2 4 2 3 0 0.616 1.000 1.000 524 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(20), HK1(3), HK2(12), HK3(15), IMPA1(2), IMPA2(2), ISYNA1(2), PGM1(4), PGM3(4), TGDS(1) 4517807 65 43 63 41 44 7 1 6 7 0 0.525 1.000 1.000 525 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(23), EP300(14), ESR1(5), MAPK1(4), MAPK3(1), PELP1(12), SRC(1) 5690711 60 43 60 30 40 3 3 10 4 0 0.632 1.000 1.000 526 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(2), IKBKAP(5), IKBKB(4), LTA(2), MAP3K1(3), MAP3K14(4), NFKB1(7), NFKBIA(2), RELA(5), RIPK1(1), TNFAIP3(2), TNFRSF1B(3), TRAF1(6), TRAF2(3), TRAF3(5) 8647884 54 43 54 48 34 8 1 6 5 0 0.997 1.000 1.000 527 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(5), FARSA(6), FARSB(5), GOT1(6), GOT2(7), PAH(9), TAT(17), YARS(1), YARS2(2) 3384610 58 42 55 26 42 6 2 3 5 0 0.107 1.000 1.000 528 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(5), ACO2(5), AFMID(3), CS(2), GRHPR(2), HAO1(8), HAO2(14), HYI(1), MDH1(1), MDH2(4), MTHFD1(10), MTHFD1L(1), MTHFD2(2) 5202281 58 42 54 30 34 5 4 6 9 0 0.335 1.000 1.000 529 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(5), CHST12(4), CHST13(3), PAPSS1(3), PAPSS2(5), SULT1A1(12), SULT1A2(4), SULT1E1(16), SULT2A1(8), SULT2B1(7), SUOX(5) 3535704 72 42 69 39 58 4 0 4 6 0 0.264 1.000 1.000 530 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(3), ECHS1(2), EHHADH(7), HADHA(8), HSD17B10(2), HSD17B4(6), NTAN1(1), SIRT2(1), SIRT5(7), SIRT7(2), VNN2(14) 4600029 53 42 51 17 34 5 3 9 2 0 0.0755 1.000 1.000 531 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(7), ANKRD1(1), CYR61(1), DUSP14(2), EIF4E(1), EIF4EBP1(1), HBEGF(1), IFNG(2), IFRD1(2), IL18(2), IL1A(4), IL1R1(12), JUND(1), MYOG(3), NR4A3(7), WDR1(5) 4123537 52 42 50 25 34 5 2 4 7 0 0.467 1.000 1.000 532 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(3), BLVRB(1), HMOX1(1), IL10(3), IL10RA(8), IL10RB(5), IL1A(4), IL6(2), JAK1(6), STAT1(4), STAT3(11), STAT5A(3), TNF(1) 4740570 52 42 51 26 24 5 6 9 8 0 0.367 1.000 1.000 533 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(23), CD34(4), CD3D(5), CD3E(2), CD3G(1), CD4(6), CD58(1), CD8A(2), CSF3(5), IL3(3), IL6(2), IL8(1), KITLG(9) 2382499 64 42 58 30 47 4 2 7 4 0 0.111 1.000 1.000 534 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), GRB2(2), IL2RG(3), IL4(1), IL4R(14), IRS1(6), JAK1(6), JAK3(7), RPS6KB1(2), SHC1(3), STAT6(8) 5721321 55 42 55 26 31 7 4 5 8 0 0.331 1.000 1.000 535 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(5), CBS(7), CTH(1), GGT1(7), MARS(6), MARS2(4), MAT1A(5), MAT2B(3), PAPSS1(3), PAPSS2(5), SCLY(3), SEPHS1(4) 4842927 53 42 52 24 33 4 3 8 5 0 0.170 1.000 1.000 536 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(6), CHAT(15), CHKA(2), PCYT1A(3), PDHA1(3), PDHA2(19), PEMT(2), SLC18A3(3) 2661585 53 41 49 26 43 5 0 2 3 0 0.119 1.000 1.000 537 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(10), FDPS(3), HMGCR(18), HMGCS1(2), IDI1(1), LSS(2), MVD(1), MVK(3), NSDHL(3), PMVK(2), SC4MOL(3), SC5DL(2), SQLE(5) 5107804 56 41 49 22 25 8 2 14 7 0 0.268 1.000 1.000 538 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(6), IFNG(2), IL10(3), IL12A(3), IL12B(4), IL13(2), IL15(3), IL16(13), IL18(2), IL1A(4), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL8(1), IL9(1), LTA(2), TNF(1) 3833389 62 41 61 35 43 3 3 4 9 0 0.215 1.000 1.000 539 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(2), JUN(1), MAPK3(1), OPRK1(23), POLR2A(12), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5) 4979606 62 41 60 56 48 3 3 3 5 0 0.985 1.000 1.000 540 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(7), CDKN1A(4), EPO(6), EPOR(1), GRIN1(7), HIF1A(5), JAK2(9), NFKB1(7), NFKBIA(2), RELA(5) 4863099 53 41 52 27 23 5 5 10 10 0 0.750 1.000 1.000 541 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(29), GNAS(22), PRKACA(4), PRKAR1A(2) 2519614 57 41 54 27 38 5 3 5 6 0 0.244 1.000 1.000 542 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(2), BET1L(1), BNIP1(2), GOSR1(1), SEC22B(5), SNAP25(6), SNAP29(1), STX10(1), STX11(2), STX12(1), STX16(2), STX17(2), STX19(2), STX2(4), STX3(2), STX5(4), STX6(2), TSNARE1(4), VAMP1(1), VAMP3(1), VAMP4(1), VAMP7(5), VAMP8(1), VTI1A(1), VTI1B(1) 6425306 55 41 52 31 31 6 2 9 7 0 0.636 1.000 1.000 543 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(6), BAX(3), BCL2(2), BIK(2), BIRC2(5), BIRC3(8), CASP3(2), CASP7(5), CASP8(9), CASP9(3), CYCS(1), DFFA(2), DFFB(3), DIABLO(1) 5239828 52 41 51 16 29 5 6 7 5 0 0.129 1.000 1.000 544 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(2), FOSL2(6), IFNAR1(2), IFNAR2(7), IFNB1(6), MAPK8(2), NFKB1(7), RELA(5), TNFRSF11A(5), TNFSF11(4), TRAF6(5) 4296255 51 41 50 27 34 3 0 9 5 0 0.688 1.000 1.000 545 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), LDLR(16), MBTPS1(9), MBTPS2(1), SCAP(8), SREBF1(5), SREBF2(10) 4601855 51 41 48 27 32 2 3 9 5 0 0.485 1.000 1.000 546 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(20), HK1(3), HK2(12), HK3(15), IMPA1(2), PGM1(4), PGM3(4), TGDS(1) 3970972 61 41 59 36 43 7 1 5 5 0 0.439 1.000 1.000 547 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(12), CYP2E1(13), NR1I3(7), PTGS1(17), PTGS2(11) 2092624 60 40 58 35 45 4 1 4 6 0 0.283 1.000 1.000 548 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), HS3ST1(11), HS3ST2(8), HS3ST3A1(4), HS3ST3B1(2), XYLT1(13), XYLT2(3) 2465347 45 40 45 39 29 6 1 5 4 0 0.844 1.000 1.000 549 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(5), ACO2(5), CS(2), GRHPR(2), HAO1(8), HAO2(14), HYI(1), MDH1(1), MDH2(4), MTHFD1(10), MTHFD1L(1), MTHFD2(2) 4966890 55 40 51 26 32 5 3 6 9 0 0.240 1.000 1.000 550 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), HS3ST1(11), HS3ST2(8), HS3ST3A1(4), HS3ST3B1(2), XYLT1(13), XYLT2(3) 2465347 45 40 45 39 29 6 1 5 4 0 0.844 1.000 1.000 551 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(8), DHRS1(3), DHRS2(7), DHRS3(4), DHRS7(1), DHRSX(4), HSD3B7(3), PON1(15), PON2(1), PON3(6), RDH11(2), RDH12(2), RDH13(3) 3509834 59 40 56 32 41 4 2 7 5 0 0.301 1.000 1.000 552 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(2), IKBKAP(5), IKBKB(4), MAP3K1(3), MAP3K14(4), NFKB1(7), NFKBIA(2), RELA(5), TNFAIP3(2), TRAF3(5), TRAF6(5) 7001774 44 39 44 34 26 8 1 6 3 0 0.979 1.000 1.000 553 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(3), DHRS2(7), DHRS3(4), DHRS7(1), DHRSX(4), ESCO1(2), ESCO2(3), MYST3(16), MYST4(16), NAT6(2), PNPLA3(2), SH3GLB1(2) 6465989 62 38 61 44 35 7 3 13 4 0 0.991 1.000 1.000 554 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(3), IFNG(2), IFNGR1(4), JAK1(6), JAK2(9), PLA2G2A(2), PTPRU(16), REG1A(8), STAT1(4) 4432488 54 38 54 23 31 2 1 9 11 0 0.326 1.000 1.000 555 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(6), CD8A(2), CSF1(11), CSF2(2), CSF3(5), EPO(6), IL11(2), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(5), IL8(1), IL9(1) 2346141 55 38 52 32 40 4 1 4 6 0 0.178 1.000 1.000 556 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(2), CD36(4), FOS(2), FYN(7), JUN(1), MAPK14(5), THBS1(30) 2875021 51 38 50 28 31 1 2 7 10 0 0.701 1.000 1.000 557 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(9), POLR2A(12), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(2) 5190884 44 37 43 18 26 4 3 6 5 0 0.188 1.000 1.000 558 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(18), CKM(2), EIF4E(1), FBL(1), GPT(3), LDHA(6), LDHB(2), LDHC(5), MAPK14(5), NCL(6) 3487077 49 37 48 23 33 2 5 5 4 0 0.354 1.000 1.000 559 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(3), IL13RA2(3), IL4R(14), JAK1(6), JAK2(9), TYK2(8) 4059082 45 37 45 23 27 3 2 8 5 0 0.660 1.000 1.000 560 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(3), IL13RA2(3), IL4R(14), JAK1(6), JAK2(9), TYK2(8) 4059082 45 37 45 23 27 3 2 8 5 0 0.660 1.000 1.000 561 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH9A1(3) 3085071 44 35 43 27 24 8 2 5 5 0 0.529 1.000 1.000 562 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH9A1(3) 3085071 44 35 43 27 24 8 2 5 5 0 0.529 1.000 1.000 563 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(10), FDPS(3), HMGCR(18), IDI1(1), LSS(2), MVD(1), MVK(3), NQO1(1), PMVK(2), SC5DL(2), SQLE(5) 4273867 48 35 41 20 20 6 2 14 6 0 0.359 1.000 1.000 564 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(9), ALPL(9), ALPP(11), ALPPL2(12), FPGS(3), GGH(2), SPR(2) 2471391 48 35 45 26 37 6 2 1 2 0 0.139 1.000 1.000 565 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(10), ACO1(5), ACO2(5), ACSS1(1), ACSS2(4), FH(3), IDH1(15), IDH2(2), MDH1(1), MDH2(4) 5192961 50 35 37 25 34 1 2 9 4 0 0.300 1.000 1.000 566 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(11), CAPN1(4), CAPNS1(1), CDK5(4), CSNK1A1(3), CSNK1D(1), GSK3B(2), MAPT(12), PPP2CA(1) 3493818 39 35 38 20 25 2 3 4 5 0 0.469 1.000 1.000 567 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(19), EIF2AK4(14), EIF2B5(1), EIF2S1(1), EIF5(2), GSK3B(2), PPP1CA(2) 4518473 41 33 37 15 18 1 2 13 7 0 0.623 1.000 1.000 568 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3), MIOX(3), UGDH(1) 3285044 41 33 39 27 22 8 4 4 3 0 0.676 1.000 1.000 569 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(20), GNA12(3), PRKACB(4), PRKACG(8), PRKAG1(2), PRKAR2A(1), PRKAR2B(5) 3916348 43 32 43 27 30 4 1 5 3 0 0.790 1.000 1.000 570 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(5), PSMA2(1), PSMA4(2), PSMA5(4), PSMA6(4), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC2(2), PSMC3(4), PSMD1(5), PSMD12(1), PSMD13(3), PSMD2(3) 6267280 41 32 40 19 23 4 2 8 4 0 0.625 1.000 1.000 571 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(2), IFNAR2(7), IFNB1(6), JAK1(6), STAT1(4), STAT2(8), TYK2(8) 4184403 42 32 42 22 21 4 2 9 6 0 0.616 1.000 1.000 572 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(6), JAK2(9), JAK3(7), MAPK1(4), MAPK3(1), STAT3(11), TYK2(8) 4514037 46 32 46 32 21 7 3 8 7 0 0.907 1.000 1.000 573 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(6), ADORA2A(2), ADORA2B(3), ADORA3(12), LTB4R(1), P2RY1(4), P2RY2(8), P2RY6(1) 2312357 37 31 37 31 24 5 0 5 3 0 0.367 1.000 1.000 574 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(8), CDC25B(6), CDC25C(5), CSK(1), GRB2(2), PRKCA(11), PTPRA(7), SRC(1) 3608410 41 31 40 27 25 7 1 5 3 0 0.818 1.000 1.000 575 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(4), NRF1(4), UBE2D1(1), UBE2D3(3), UBE2E1(1), UBE2E3(1), UBE2G2(1), UBE2H(1), UBE2I(3), UBE2J1(2), UBE2J2(6), UBE2L6(2), UBE2M(1), UBE2S(2), UBE3A(7) 4108473 39 31 38 19 26 5 1 5 2 0 0.626 1.000 1.000 576 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(13), ENO1(4), GPI(3), HK1(3), PFKL(4), PGK1(5), PKLR(11) 3560526 43 30 40 19 29 4 1 5 4 0 0.0513 1.000 1.000 577 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(4), BIRC3(8), CASP8(9), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF2(3) 3182250 32 30 31 13 23 1 2 3 3 0 0.244 1.000 1.000 578 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3D(5), CD3E(2), CD3G(1), IFNG(2), IL2(4), IL2RA(4), IL4(1), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(7), TGFBR3(6), TOB1(3), TOB2(2) 4087982 43 30 43 27 33 2 0 1 7 0 0.643 1.000 1.000 579 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(6), ACAA2(2), ACAT2(1), ECHS1(2), EHHADH(7), HADHA(8), HADHB(4), SDS(2) 3247830 32 29 31 14 20 3 2 4 3 0 0.398 1.000 1.000 580 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(3), GBA(5), GBA3(14), GGT1(7), SHMT1(1), SHMT2(3) 2082062 33 29 31 17 24 2 0 4 3 0 0.259 1.000 1.000 581 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(2), CTSD(3), ESR1(5), GREB1(18), HSPB1(2), HSPB2(1), MTA1(2), MTA3(3), PDZK1(3), TUBA8(3) 4139828 42 29 41 28 31 2 3 4 2 0 0.614 1.000 1.000 582 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(5), PSMA2(1), PSMA4(2), PSMA5(4), PSMA6(4), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC3(4), PSMD14(1), RPN2(2), UBE3A(7) 5044703 37 29 37 20 20 4 1 8 4 0 0.807 1.000 1.000 583 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(6), CPS1(22), GLS(2), GLUD1(2), GOT1(6) 2970287 40 29 38 17 25 4 2 7 2 0 0.313 1.000 1.000 584 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD4(6), CD80(5), HLA-DRA(11), HLA-DRB1(4), IL10(3), IL2(4), IL4(1) 1530275 35 28 35 21 23 1 1 6 4 0 0.408 1.000 1.000 585 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(5), B3GALT1(12), B3GALT2(1), B3GALT5(1), B3GNT5(1), FUT1(3), FUT2(3), FUT3(6), ST3GAL3(2), ST3GAL4(1) 2781181 35 28 34 28 26 3 0 4 2 0 0.835 1.000 1.000 586 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(7), ADSS(2), IMPDH1(2), MTHFD2(2), POLD1(6), POLG(9), PRPS2(4), RRM1(3) 4820434 35 28 35 26 19 3 1 5 7 0 0.946 1.000 1.000 587 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 FOS(2), JUN(1), KEAP1(2), MAFG(1), MAFK(1), MAPK1(4), MAPK14(5), MAPK8(2), NFE2L2(4), PRKCA(11) 3431224 33 27 32 15 22 2 0 4 5 0 0.403 1.000 1.000 588 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(6), CLOCK(5), CRY1(7), CRY2(3), CSNK1E(4), PER1(8) 3279256 33 27 32 17 19 3 2 3 6 0 0.722 1.000 1.000 589 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(2), CASP7(5), DFFA(2), DFFB(3), GZMB(3), HMGB1(1), HMGB2(1), TOP2A(10), TOP2B(8) 3473938 35 27 35 12 23 1 4 5 2 0 0.356 1.000 1.000 590 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(8), PLCG1(9), PRKCA(11), PTK2B(11) 2623613 39 27 38 29 29 4 1 2 3 0 0.642 1.000 1.000 591 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(2), RANBP2(24), RANGAP1(3) 3307782 29 27 29 12 19 2 1 3 4 0 0.616 1.000 1.000 592 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(2), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT5(3), FUT8(8), ST3GAL1(6), ST3GAL2(1), ST3GAL3(2), ST3GAL4(1) 3046319 30 26 29 19 16 6 3 2 3 0 0.710 1.000 1.000 593 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(2), CDC25A(8), CDC25B(6), CDC25C(5), MNAT1(2), SHH(5), XPO1(2) 3391180 30 26 30 14 15 5 2 6 2 0 0.673 1.000 1.000 594 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(2), HBXIP(1), HRAS(4), PTK2B(11), SHC1(3), SOS1(9), SRC(1) 3418083 31 25 31 22 20 3 1 5 2 0 0.942 1.000 1.000 595 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(1), BDH1(5), HMGCL(4), HMGCS1(2), HMGCS2(18), OXCT1(5), OXCT2(4) 2775498 39 25 38 23 25 5 0 6 3 0 0.754 1.000 1.000 596 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 11 ALAD(5), ALAS1(1), ALAS2(5), CPO(2), FECH(3), GATA1(3), HBB(6), HMBS(2), UROS(1) 2966192 28 24 27 19 21 2 0 1 4 0 0.673 1.000 1.000 597 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(14), GGT1(7), SHMT1(1), SHMT2(3) 1577501 25 24 23 16 18 2 0 3 2 0 0.444 1.000 1.000 598 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), CSF1(11), IL1B(7), MST1(2), MST1R(8), TNF(1) 2541526 30 24 29 22 23 2 1 0 4 0 0.800 1.000 1.000 599 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(5), FUT1(3), FUT2(3), FUT3(6), FUT5(6), FUT6(4), ST3GAL3(2) 1937625 29 23 29 19 17 3 1 3 5 0 0.418 1.000 1.000 600 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(5), APOBEC1(6), APOBEC2(4), APOBEC3A(2), APOBEC3B(2), APOBEC3C(2), APOBEC3F(4), APOBEC3G(2) 2871510 27 23 27 28 21 2 3 1 0 0 0.987 1.000 1.000 601 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(5), CS(2), FH(3), IDH2(2), MDH1(1), OGDH(11), SDHA(3) 3679477 27 23 26 21 17 1 2 3 4 0 0.912 1.000 1.000 602 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(24), PNPO(1), PSAT1(2) 1889662 27 22 25 19 23 1 1 2 0 0 0.804 1.000 1.000 603 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(5), ALAS1(1), ALAS2(5), CPOX(4), FECH(3), HMBS(2), PPOX(3), UROS(1) 2939301 24 21 24 10 16 2 1 2 3 0 0.290 1.000 1.000 604 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), CD4(6), HLA-DRA(11), HLA-DRB1(4) 913436 22 20 22 15 17 1 0 3 1 0 0.559 1.000 1.000 605 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(1), COQ3(4), COQ5(3), COQ6(2), COQ7(2), NDUFA12(1), NDUFA13(7) 1546546 20 20 18 12 14 1 3 1 1 0 0.764 1.000 1.000 606 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(8), EPHX2(4), HSD3B7(3), RDH11(2), RDH12(2), RDH13(3) 1871393 22 19 22 19 15 1 2 1 3 0 0.854 1.000 1.000 607 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(4), IFNGR2(4), JAK1(6), JAK2(9), STAT1(4) 3171955 29 19 27 10 11 1 1 7 9 0 0.687 1.000 1.000 608 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(5), BMPR1A(2), BMPR1B(4), BMPR2(6) 2440597 17 17 17 11 7 3 0 3 4 0 0.839 1.000 1.000 609 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL1(6), ST3GAL2(1), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(2), ST6GALNAC4(1), ST8SIA1(1) 2203596 16 16 16 12 11 2 1 2 0 0 0.725 1.000 1.000 610 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(7), CD28(1), CD3D(5), CD3E(2), CD3G(1), CD4(6) 1244752 22 16 22 24 15 3 0 3 1 0 0.959 1.000 1.000 611 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(1), DLL1(4), FURIN(5), NOTCH1(5), PSEN1(1) 3566145 16 15 16 18 9 3 1 3 0 0 0.973 1.000 1.000 612 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(4), HGD(12) 873451 16 14 16 17 12 2 2 0 0 0 0.958 1.000 1.000 613 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(6), ARG1(2), GLS(2), GLUD1(2), OAT(3), PRODH(1) 2114541 16 12 16 13 6 5 2 2 1 0 0.928 1.000 1.000 614 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(17) 709023 19 12 18 11 14 2 1 2 0 0 0.580 1.000 1.000 615 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), GALT(2), TGDS(1), UGDH(1), UGP2(2), UXS1(4) 1914223 11 11 11 10 5 0 1 0 5 0 0.963 1.000 1.000 616 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(4) 825779 4 4 4 5 3 0 0 1 0 0 0.943 1.000 1.000