E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.089 0.19 -9999.0 0.0 -0.391 79.0 79.0 KLHL20 -0.015 0.082 -9999.0 0.0 -0.204 14.0 14.0 CYFIP2 -0.013 0.104 -9999.0 0.0 -0.409 18.0 18.0 Rac1/GDP -0.031 0.12 -9999.0 0.0 -0.22 75.0 75.0 ENAH -0.093 0.192 -9999.0 0.0 -0.396 79.0 79.0 AP1M1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.012 0.019 -9999.0 0.0 -0.306 1.0 1.0 RAP1A 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.043 0.064 -9999.0 0.0 -0.278 2.0 2.0 ABI1/Sra1/Nap1 -0.033 0.046 -9999.0 0.0 -0.146 19.0 19.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.058 0.13 -9999.0 0.0 -0.232 91.0 91.0 RAPGEF1 -0.068 0.169 -9999.0 0.0 -0.336 79.0 79.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.097 0.195 -9999.0 0.0 -0.407 79.0 79.0 CRK -0.079 0.181 -9999.0 0.0 -0.367 79.0 79.0 E-cadherin/gamma catenin/alpha catenin -0.065 0.128 -9999.0 0.0 -0.231 101.0 101.0 alphaE/beta7 Integrin -0.002 0.08 -9999.0 0.0 -0.291 20.0 20.0 IQGAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.022 0.032 -9999.0 0.0 -0.218 4.0 4.0 DLG1 -0.089 0.19 -9999.0 0.0 -0.391 79.0 79.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.033 0.049 -9999.0 0.0 -0.221 3.0 3.0 MLLT4 0.006 0.056 -9999.0 0.0 -0.405 5.0 5.0 ARF6/GTP/NME1/Tiam1 0.011 0.059 -9999.0 0.0 -0.218 17.0 17.0 PI3K -0.041 0.062 -9999.0 0.0 -0.289 3.0 3.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.089 0.15 -9999.0 0.0 -0.284 101.0 101.0 TIAM1 -0.014 0.107 -9999.0 0.0 -0.422 18.0 18.0 E-cadherin(dimer)/Ca2+ -0.04 0.104 -9999.0 0.0 -0.198 79.0 79.0 AKT1 -0.024 0.036 -9999.0 0.0 -0.161 3.0 3.0 PIK3R1 0.01 0.037 -9999.0 0.0 -0.429 2.0 2.0 CDH1 -0.125 0.201 -9999.0 0.0 -0.412 92.0 92.0 RhoA/GDP -0.032 0.12 -9999.0 0.0 -0.22 75.0 75.0 actin cytoskeleton organization -0.01 0.063 -9999.0 0.0 -0.15 14.0 14.0 CDC42/GDP -0.032 0.12 -9999.0 0.0 -0.22 75.0 75.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.052 0.106 -9999.0 0.0 -0.214 80.0 80.0 ITGB7 -0.017 0.112 -9999.0 0.0 -0.423 20.0 20.0 RAC1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.042 0.112 -9999.0 0.0 -0.212 79.0 79.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.047 0.103 -9999.0 0.0 -0.204 79.0 79.0 mol:GDP -0.045 0.134 -9999.0 0.0 -0.255 79.0 79.0 CDC42/GTP/IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP -0.002 0.072 -9999.0 0.0 -0.325 13.0 13.0 p120 catenin/RhoA/GDP -0.032 0.121 -9999.0 0.0 -0.223 75.0 75.0 RAC1/GTP/IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.004 0.047 -9999.0 0.0 -0.152 7.0 7.0 NME1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.093 0.191 -9999.0 0.0 -0.393 79.0 79.0 regulation of cell-cell adhesion -0.039 0.057 -9999.0 0.0 -0.245 2.0 2.0 WASF2 -0.017 0.025 -9999.0 0.0 -0.108 2.0 2.0 Rap1/GTP -0.049 0.074 -9999.0 0.0 -0.318 2.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.056 0.127 -9999.0 0.0 -0.22 91.0 91.0 CCND1 -0.006 0.057 -9999.0 0.0 -0.187 7.0 7.0 VAV2 -0.089 0.203 -9999.0 0.0 -0.388 84.0 84.0 RAP1/GDP -0.025 0.102 -9999.0 0.0 -0.297 3.0 3.0 adherens junction assembly -0.09 0.185 -9999.0 0.0 -0.382 79.0 79.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.049 0.122 -9999.0 0.0 -0.378 12.0 12.0 E-cadherin/beta catenin -0.091 0.138 -9999.0 0.0 -0.309 79.0 79.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.089 0.191 -9999.0 0.0 -0.393 79.0 79.0 PIK3CA 0.007 0.052 -9999.0 0.0 -0.429 4.0 4.0 Rac1/GTP -0.066 0.098 -9999.0 0.0 -0.331 14.0 14.0 E-cadherin/beta catenin/alpha catenin -0.056 0.122 -9999.0 0.0 -0.242 79.0 79.0 ITGAE 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.099 0.199 -9999.0 0.0 -0.415 79.0 79.0