Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.036 0.186 -9999.0 0.0 -0.548 25.0 25.0 IHH -0.002 0.057 -9999.0 0.0 -0.334 4.0 4.0 SHH Np/Cholesterol/GAS1 0.002 0.054 -9999.0 0.0 -0.178 22.0 22.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.002 0.053 0.177 22.0 -9999.0 0.0 22.0 SMO/beta Arrestin2 -0.032 0.148 -9999.0 0.0 -0.468 16.0 16.0 SMO -0.041 0.155 -9999.0 0.0 -0.496 16.0 16.0 AKT1 -0.006 0.084 -9999.0 0.0 -0.305 5.0 5.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.015 0.101 -9999.0 0.0 -0.365 21.0 21.0 ADRBK1 0.012 0.026 -9999.0 0.0 -0.429 1.0 1.0 heart looping -0.04 0.153 -9999.0 0.0 -0.489 16.0 16.0 STIL -0.008 0.1 -9999.0 0.0 -0.366 10.0 10.0 DHH N/PTCH2 -0.033 0.111 -9999.0 0.0 -0.25 55.0 55.0 DHH N/PTCH1 -0.036 0.138 -9999.0 0.0 -0.389 20.0 20.0 PIK3CA 0.007 0.052 -9999.0 0.0 -0.429 4.0 4.0 DHH -0.045 0.135 -9999.0 0.0 -0.346 46.0 46.0 PTHLH -0.05 0.239 -9999.0 0.0 -0.767 23.0 23.0 determination of left/right symmetry -0.04 0.153 -9999.0 0.0 -0.489 16.0 16.0 PIK3R1 0.01 0.037 -9999.0 0.0 -0.429 2.0 2.0 skeletal system development -0.049 0.237 -9999.0 0.0 -0.73 25.0 25.0 IHH N/Hhip -0.008 0.073 -9999.0 0.0 -0.245 21.0 21.0 DHH N/Hhip -0.039 0.108 -9999.0 0.0 -0.236 62.0 62.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.04 0.153 -9999.0 0.0 -0.489 16.0 16.0 pancreas development -0.013 0.081 -9999.0 0.0 -0.306 20.0 20.0 HHAT 0.006 0.058 -9999.0 0.0 -0.429 5.0 5.0 PI3K 0.014 0.05 -9999.0 0.0 -0.348 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.005 0.061 -9999.0 0.0 -0.409 6.0 6.0 somite specification -0.04 0.153 -9999.0 0.0 -0.489 16.0 16.0 SHH Np/Cholesterol/PTCH1 -0.012 0.105 -9999.0 0.0 -0.388 10.0 10.0 SHH Np/Cholesterol/PTCH2 -0.002 0.061 -9999.0 0.0 -0.18 28.0 28.0 SHH Np/Cholesterol/Megalin -0.11 0.113 -9999.0 0.0 -0.192 171.0 171.0 SHH -0.002 0.058 -9999.0 0.0 -0.232 16.0 16.0 catabolic process -0.014 0.124 -9999.0 0.0 -0.37 21.0 21.0 SMO/Vitamin D3 -0.024 0.124 -9999.0 0.0 -0.398 17.0 17.0 SHH Np/Cholesterol/Hhip -0.007 0.063 -9999.0 0.0 -0.175 32.0 32.0 LRP2 -0.209 0.193 -9999.0 0.0 -0.368 164.0 164.0 receptor-mediated endocytosis -0.097 0.148 -9999.0 0.0 -0.459 24.0 24.0 SHH Np/Cholesterol/BOC -0.008 0.069 -9999.0 0.0 -0.181 36.0 36.0 SHH Np/Cholesterol/CDO 0.004 0.049 -9999.0 0.0 -0.175 19.0 19.0 mesenchymal cell differentiation 0.007 0.063 0.174 32.0 -9999.0 0.0 32.0 mol:Vitamin D3 -0.01 0.106 -9999.0 0.0 -0.39 10.0 10.0 IHH N/PTCH2 -0.001 0.072 -9999.0 0.0 -0.29 14.0 14.0 CDON 0.009 0.045 -9999.0 0.0 -0.429 3.0 3.0 IHH N/PTCH1 -0.012 0.126 -9999.0 0.0 -0.372 21.0 21.0 Megalin/LRPAP1 -0.136 0.137 -9999.0 0.0 -0.248 164.0 164.0 PTCH2 -0.004 0.08 -9999.0 0.0 -0.363 13.0 13.0 SHH Np/Cholesterol -0.0 0.043 -9999.0 0.0 -0.173 16.0 16.0 PTCH1 -0.014 0.124 -9999.0 0.0 -0.371 21.0 21.0 HHIP -0.013 0.081 -9999.0 0.0 -0.306 20.0 20.0