Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.041 0.101 -9999.0 0.0 -0.2 79.0 79.0 epithelial cell differentiation -0.041 0.102 -9999.0 0.0 -0.197 79.0 79.0 CYFIP2 -0.013 0.104 -9999.0 0.0 -0.409 18.0 18.0 ENAH -0.014 0.083 -9999.0 0.0 -0.241 8.0 8.0 EGFR -0.028 0.115 -9999.0 0.0 -0.34 33.0 33.0 EPHA2 -0.006 0.089 -9999.0 0.0 -0.41 13.0 13.0 MYO6 -0.044 0.102 -9999.0 0.0 -0.187 88.0 88.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.011 0.063 -9999.0 0.0 -0.242 15.0 15.0 AQP5 -0.047 0.109 -9999.0 0.0 -0.469 6.0 6.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.036 0.095 -9999.0 0.0 -0.181 79.0 79.0 regulation of calcium-dependent cell-cell adhesion -0.047 0.107 -9999.0 0.0 -0.197 84.0 84.0 EGF -0.097 0.183 -9999.0 0.0 -0.395 76.0 76.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.053 0.142 -9999.0 0.0 -0.493 17.0 17.0 cortical microtubule organization -0.041 0.102 -9999.0 0.0 -0.197 79.0 79.0 GO:0000145 -0.035 0.09 -9999.0 0.0 -0.173 79.0 79.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.04 0.104 -9999.0 0.0 -0.199 79.0 79.0 MLLT4 0.006 0.056 -9999.0 0.0 -0.405 5.0 5.0 ARF6/GDP -0.051 0.071 -9999.0 0.0 -0.28 4.0 4.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.024 0.05 -9999.0 0.0 -0.212 11.0 11.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.028 0.092 -9999.0 0.0 -0.221 2.0 2.0 PVRL2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.037 0.099 -9999.0 0.0 -0.187 79.0 79.0 ARF6/GTP 0.028 0.046 -9999.0 0.0 -0.191 11.0 11.0 CDH1 -0.125 0.201 -9999.0 0.0 -0.412 92.0 92.0 EGFR/EGFR/EGF/EGF -0.114 0.13 -9999.0 0.0 -0.371 40.0 40.0 RhoA/GDP -0.036 0.095 -9999.0 0.0 -0.181 79.0 79.0 actin cytoskeleton organization -0.038 0.099 -9999.0 0.0 -0.328 2.0 2.0 IGF-1R heterotetramer 0.009 0.042 -9999.0 0.0 -0.388 3.0 3.0 GIT1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.009 0.042 -9999.0 0.0 -0.388 3.0 3.0 IGF1 -0.02 0.113 -9999.0 0.0 -0.397 23.0 23.0 DIAPH1 -0.026 0.132 -9999.0 0.0 -0.58 15.0 15.0 Wnt receptor signaling pathway 0.041 0.102 0.197 79.0 -9999.0 0.0 79.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.051 0.071 -9999.0 0.0 -0.28 4.0 4.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.039 0.101 -9999.0 0.0 -0.336 2.0 2.0 EFNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.033 0.093 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.061 0.085 -9999.0 0.0 -0.322 4.0 4.0 SEC6/SEC8 -0.05 0.071 -9999.0 0.0 -0.342 1.0 1.0 MGAT3 -0.048 0.108 -9999.0 0.0 -0.2 84.0 84.0 HGF/MET -0.094 0.117 -9999.0 0.0 -0.343 32.0 32.0 HGF -0.025 0.114 -9999.0 0.0 -0.357 29.0 29.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.041 0.102 -9999.0 0.0 -0.201 79.0 79.0 actin cable formation -0.003 0.082 -9999.0 0.0 -0.234 5.0 5.0 KIAA1543 -0.077 0.119 -9999.0 0.0 -0.323 26.0 26.0 KIFC3 -0.037 0.097 -9999.0 0.0 -0.183 80.0 80.0 NCK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.019 -9999.0 0.0 -0.306 1.0 1.0 ACTN1 -0.039 0.098 -9999.0 0.0 -0.183 83.0 83.0 NCK1/GIT1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.041 0.102 -9999.0 0.0 -0.197 79.0 79.0 EXOC4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.036 0.096 -9999.0 0.0 -0.183 79.0 79.0 PIP5K1C -0.036 0.096 -9999.0 0.0 -0.183 79.0 79.0 LIMA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.019 0.087 -9999.0 0.0 -0.258 5.0 5.0 adherens junction assembly -0.059 0.116 -9999.0 0.0 -0.304 23.0 23.0 IGF-1R heterotetramer/IGF1 -0.068 0.092 -9999.0 0.0 -0.188 92.0 92.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.015 0.04 -9999.0 0.0 -0.277 5.0 5.0 MET -0.051 0.151 -9999.0 0.0 -0.398 44.0 44.0 PLEKHA7 -0.047 0.108 -9999.0 0.0 -0.197 87.0 87.0 mol:GTP 0.023 0.049 -9999.0 0.0 -0.211 11.0 11.0 establishment of epithelial cell apical/basal polarity -0.016 0.089 -9999.0 0.0 -0.325 1.0 1.0 cortical actin cytoskeleton stabilization -0.041 0.101 -9999.0 0.0 -0.2 79.0 79.0 regulation of cell-cell adhesion -0.038 0.099 -9999.0 0.0 -0.328 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.041 0.102 -9999.0 0.0 -0.201 79.0 79.0