E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.097 0.184 -9999.0 0.0 -0.367 86.0 86.0 KLHL20 -0.028 0.093 0.19 5.0 -0.217 23.0 28.0 CYFIP2 0.013 0.071 0.149 3.0 -0.318 12.0 15.0 Rac1/GDP -0.047 0.118 0.213 3.0 -0.232 64.0 67.0 ENAH -0.093 0.179 0.236 1.0 -0.372 77.0 78.0 AP1M1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.02 0.082 -9999.0 0.0 -0.158 59.0 59.0 ABI1/Sra1/Nap1 -0.04 0.054 -9999.0 0.0 -0.144 31.0 31.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.008 0.115 -9999.0 0.0 -0.177 85.0 85.0 RAPGEF1 -0.079 0.168 0.26 4.0 -0.332 79.0 83.0 CTNND1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.092 0.193 -9999.0 0.0 -0.374 88.0 88.0 CRK -0.085 0.176 0.226 1.0 -0.353 80.0 81.0 E-cadherin/gamma catenin/alpha catenin -0.007 0.114 0.213 1.0 -0.191 74.0 75.0 alphaE/beta7 Integrin 0.025 0.061 -9999.0 0.0 -0.218 16.0 16.0 IQGAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.042 0.032 -9999.0 0.0 -0.162 4.0 4.0 DLG1 -0.096 0.183 -9999.0 0.0 -0.368 86.0 86.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.042 0.049 -9999.0 0.0 -0.125 61.0 61.0 MLLT4 0.02 0.042 -9999.0 0.0 -0.318 4.0 4.0 ARF6/GTP/NME1/Tiam1 0.04 0.05 -9999.0 0.0 -0.167 14.0 14.0 PI3K -0.052 0.062 -9999.0 0.0 -0.157 61.0 61.0 ARF6 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.024 0.124 0.216 1.0 -0.226 74.0 75.0 TIAM1 0.011 0.076 0.149 1.0 -0.318 14.0 15.0 E-cadherin(dimer)/Ca2+ 0.004 0.101 -9999.0 0.0 -0.16 74.0 74.0 AKT1 -0.025 0.05 0.126 3.0 -0.148 3.0 6.0 PIK3R1 0.025 0.029 -9999.0 0.0 -0.318 2.0 2.0 CDH1 -0.059 0.157 0.149 12.0 -0.318 74.0 86.0 RhoA/GDP -0.045 0.127 0.244 5.0 -0.231 69.0 74.0 actin cytoskeleton organization -0.019 0.072 0.163 6.0 -0.16 22.0 28.0 CDC42/GDP -0.045 0.126 0.244 5.0 -0.231 68.0 73.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.034 0.095 -9999.0 0.0 -0.19 74.0 74.0 ITGB7 0.009 0.081 0.149 1.0 -0.318 16.0 17.0 RAC1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.005 0.109 -9999.0 0.0 -0.172 74.0 74.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.006 0.092 -9999.0 0.0 -0.156 74.0 74.0 mol:GDP -0.063 0.134 0.247 5.0 -0.261 69.0 74.0 CDC42/GTP/IQGAP1 0.036 0.01 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.03 0.038 0.149 11.0 -0.318 2.0 13.0 p120 catenin/RhoA/GDP -0.04 0.13 0.233 4.0 -0.237 67.0 71.0 RAC1/GTP/IQGAP1 0.033 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.042 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.01 0.055 0.133 9.0 -0.107 24.0 33.0 NME1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.1 0.185 -9999.0 0.0 -0.368 88.0 88.0 regulation of cell-cell adhesion -0.026 0.066 -9999.0 0.0 -0.141 59.0 59.0 WASF2 -0.014 0.04 0.089 3.0 -0.09 11.0 14.0 Rap1/GTP -0.021 0.095 0.256 3.0 -0.172 58.0 61.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.002 0.12 -9999.0 0.0 -0.171 85.0 85.0 CCND1 -0.013 0.065 0.153 9.0 -0.13 24.0 33.0 VAV2 -0.119 0.245 0.36 1.0 -0.638 28.0 29.0 RAP1/GDP -0.026 0.108 0.267 3.0 -0.189 64.0 67.0 adherens junction assembly -0.097 0.18 -9999.0 0.0 -0.357 88.0 88.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.01 0.108 0.189 3.0 -0.168 83.0 86.0 E-cadherin/beta catenin -0.063 0.127 -9999.0 0.0 -0.276 73.0 73.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.095 0.181 0.236 1.0 -0.367 83.0 84.0 PIK3CA 0.023 0.041 -9999.0 0.0 -0.318 4.0 4.0 Rac1/GTP -0.074 0.123 -9999.0 0.0 -0.335 29.0 29.0 E-cadherin/beta catenin/alpha catenin -0.009 0.109 -9999.0 0.0 -0.187 74.0 74.0 ITGAE 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.095 0.196 -9999.0 0.0 -0.382 88.0 88.0