Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	54.0	383.0	7.0	-0.047	0.0	1000.0	-1000.0	-0.007	-1000.0
TCR signaling in naïve CD8+ T cells	49.0	4640.0	93.0	-0.182	0.138	1000.0	-1000.0	-0.037	-1000.0
E-cadherin signaling events	49.0	248.0	5.0	-0.059	0.03	1000.0	-1000.0	0.021	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	44.0	3460.0	78.0	-0.214	0.071	1000.0	-1000.0	-0.032	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	40.0	3021.0	74.0	-0.059	0.056	1000.0	-1000.0	-0.038	-1000.0
IL12-mediated signaling events	38.0	3331.0	87.0	-0.251	0.057	1000.0	-1000.0	-0.038	-1000.0
IL4-mediated signaling events	38.0	3511.0	91.0	-0.473	0.344	1000.0	-1000.0	-0.061	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	37.0	2522.0	68.0	-0.281	0.078	1000.0	-1000.0	-0.032	-1000.0
E-cadherin signaling in the nascent adherens junction	37.0	2847.0	76.0	-0.119	0.042	1000.0	-1000.0	-0.033	-1000.0
IL23-mediated signaling events	37.0	2240.0	60.0	-0.285	0.028	1000.0	-1000.0	-0.065	-1000.0
Syndecan-1-mediated signaling events	34.0	1172.0	34.0	-0.05	0.028	1000.0	-1000.0	-0.013	-1000.0
Signaling events regulated by Ret tyrosine kinase	33.0	2708.0	82.0	-0.048	0.036	1000.0	-1000.0	-0.031	-1000.0
Wnt signaling	33.0	234.0	7.0	-0.03	0.025	1000.0	-1000.0	-0.001	-1000.0
Angiopoietin receptor Tie2-mediated signaling	33.0	2919.0	88.0	-0.176	0.036	1000.0	-1000.0	-0.054	-1000.0
E-cadherin signaling in keratinocytes	32.0	1389.0	43.0	-0.064	0.032	1000.0	-1000.0	-0.015	-1000.0
BCR signaling pathway	31.0	3091.0	99.0	-0.126	0.038	1000.0	-1000.0	-0.035	-1000.0
Glypican 1 network	30.0	1457.0	48.0	-0.037	0.038	1000.0	-1000.0	-0.024	-1000.0
Endothelins	30.0	2927.0	96.0	-0.119	0.044	1000.0	-1000.0	-0.031	-1000.0
LPA receptor mediated events	29.0	3026.0	102.0	-0.082	0.031	1000.0	-1000.0	-0.057	-1000.0
p75(NTR)-mediated signaling	28.0	3553.0	125.0	-0.05	0.071	1000.0	-1000.0	-0.034	-1000.0
Nectin adhesion pathway	28.0	1821.0	63.0	-0.101	0.042	1000.0	-1000.0	-0.036	-1000.0
TCGA08_retinoblastoma	27.0	222.0	8.0	-0.007	0.048	1000.0	-1000.0	-0.004	-1000.0
Integrins in angiogenesis	26.0	2209.0	84.0	-0.101	0.05	1000.0	-1000.0	-0.017	-1000.0
EGFR-dependent Endothelin signaling events	26.0	556.0	21.0	-0.035	0.04	1000.0	-1000.0	-0.027	-1000.0
Noncanonical Wnt signaling pathway	25.0	672.0	26.0	-0.043	0.027	1000.0	-1000.0	-0.027	-1000.0
Glypican 2 network	25.0	100.0	4.0	0.011	0.012	1000.0	-1000.0	0.019	-1000.0
S1P4 pathway	25.0	644.0	25.0	-0.033	0.037	1000.0	-1000.0	-0.008	-1000.0
BMP receptor signaling	24.0	1978.0	81.0	-0.048	0.051	1000.0	-1000.0	-0.019	-1000.0
Glucocorticoid receptor regulatory network	24.0	2766.0	114.0	-0.218	0.111	1000.0	-1000.0	-0.035	-1000.0
JNK signaling in the CD4+ TCR pathway	23.0	403.0	17.0	-0.09	0.037	1000.0	-1000.0	-0.013	-1000.0
Thromboxane A2 receptor signaling	23.0	2425.0	105.0	-0.078	0.033	1000.0	-1000.0	-0.026	-1000.0
a4b1 and a4b7 Integrin signaling	23.0	119.0	5.0	0.002	0.019	1000.0	-1000.0	0.021	-1000.0
FAS signaling pathway (CD95)	23.0	1122.0	47.0	-0.026	0.037	1000.0	-1000.0	-0.03	-1000.0
EPHB forward signaling	23.0	2018.0	85.0	-0.051	0.057	1000.0	-1000.0	-0.039	-1000.0
Class IB PI3K non-lipid kinase events	23.0	69.0	3.0	-0.004	0.004	1000.0	-1000.0	-0.022	-1000.0
Caspase cascade in apoptosis	22.0	1653.0	74.0	-0.061	0.043	1000.0	-1000.0	-0.024	-1000.0
Osteopontin-mediated events	22.0	871.0	38.0	-0.052	0.031	1000.0	-1000.0	-0.025	-1000.0
HIF-1-alpha transcription factor network	22.0	1672.0	76.0	-0.019	0.065	1000.0	-1000.0	-0.024	-1000.0
Arf6 signaling events	21.0	1333.0	62.0	-0.027	0.052	1000.0	-1000.0	-0.028	-1000.0
Signaling mediated by p38-alpha and p38-beta	21.0	936.0	44.0	-0.053	0.032	1000.0	-1000.0	-0.011	-1000.0
Calcium signaling in the CD4+ TCR pathway	21.0	668.0	31.0	-0.068	0.029	1000.0	-1000.0	-0.035	-1000.0
Syndecan-4-mediated signaling events	21.0	1410.0	67.0	-0.041	0.036	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by PTP1B	20.0	1575.0	76.0	-0.06	0.042	1000.0	-1000.0	-0.032	-1000.0
Ephrin B reverse signaling	20.0	961.0	48.0	-0.047	0.042	1000.0	-1000.0	-0.028	-1000.0
Plasma membrane estrogen receptor signaling	20.0	1792.0	86.0	-0.122	0.09	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by the Hedgehog family	19.0	1018.0	52.0	-0.038	0.046	1000.0	-1000.0	-0.018	-1000.0
Fc-epsilon receptor I signaling in mast cells	19.0	1868.0	97.0	-0.048	0.049	1000.0	-1000.0	-0.033	-1000.0
S1P5 pathway	19.0	328.0	17.0	-0.028	0.032	1000.0	-1000.0	-0.004	-1000.0
Effects of Botulinum toxin	19.0	511.0	26.0	-0.017	0.041	1000.0	-1000.0	-0.008	-1000.0
IL27-mediated signaling events	19.0	1013.0	51.0	-0.149	0.084	1000.0	-1000.0	-0.035	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	18.0	1608.0	85.0	-0.037	0.035	1000.0	-1000.0	-0.04	-1000.0
amb2 Integrin signaling	18.0	1550.0	82.0	-0.036	0.044	1000.0	-1000.0	-0.016	-1000.0
Ceramide signaling pathway	18.0	1415.0	76.0	-0.042	0.048	1000.0	-1000.0	-0.018	-1000.0
Reelin signaling pathway	18.0	1024.0	56.0	-0.022	0.064	1000.0	-1000.0	-0.014	-1000.0
TRAIL signaling pathway	18.0	892.0	48.0	-0.031	0.045	1000.0	-1000.0	-0.016	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	18.0	848.0	45.0	-0.046	0.056	1000.0	-1000.0	-0.02	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	17.0	918.0	52.0	-0.048	0.056	1000.0	-1000.0	-0.026	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	17.0	2142.0	120.0	-0.09	0.071	1000.0	-1000.0	-0.028	-1000.0
ErbB2/ErbB3 signaling events	16.0	1050.0	65.0	-0.036	0.04	1000.0	-1000.0	-0.053	-1000.0
IL2 signaling events mediated by PI3K	16.0	936.0	58.0	-0.09	0.041	1000.0	-1000.0	-0.03	-1000.0
Class I PI3K signaling events	16.0	1228.0	73.0	-0.082	0.05	1000.0	-1000.0	-0.02	-1000.0
Ras signaling in the CD4+ TCR pathway	16.0	286.0	17.0	-0.019	0.051	1000.0	-1000.0	-0.01	-1000.0
Syndecan-2-mediated signaling events	15.0	1063.0	69.0	-0.012	0.041	1000.0	-1000.0	-0.026	-1000.0
IFN-gamma pathway	15.0	1022.0	68.0	-0.03	0.038	1000.0	-1000.0	-0.037	-1000.0
IL1-mediated signaling events	14.0	879.0	62.0	-0.027	0.074	1000.0	-1000.0	-0.019	-1000.0
ceramide signaling pathway	14.0	711.0	49.0	-0.021	0.04	1000.0	-1000.0	-0.02	-1000.0
TCGA08_p53	14.0	102.0	7.0	-0.01	0.024	1000.0	-1000.0	-0.01	-1000.0
Signaling mediated by p38-gamma and p38-delta	14.0	210.0	15.0	-0.015	0.027	1000.0	-1000.0	-0.02	-1000.0
LPA4-mediated signaling events	13.0	166.0	12.0	-0.04	0.0	1000.0	-1000.0	-0.016	-1000.0
Sphingosine 1-phosphate (S1P) pathway	13.0	365.0	28.0	-0.028	0.043	1000.0	-1000.0	-0.018	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	13.0	717.0	54.0	-0.016	0.043	1000.0	-1000.0	-0.017	-1000.0
S1P1 pathway	13.0	473.0	36.0	-0.06	0.028	1000.0	-1000.0	-0.021	-1000.0
IL2 signaling events mediated by STAT5	13.0	303.0	22.0	-0.029	0.028	1000.0	-1000.0	-0.015	-1000.0
S1P3 pathway	13.0	568.0	42.0	-0.028	0.044	1000.0	-1000.0	-0.021	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	12.0	476.0	37.0	-0.031	0.046	1000.0	-1000.0	-0.018	-1000.0
Paxillin-dependent events mediated by a4b1	12.0	440.0	36.0	-0.036	0.046	1000.0	-1000.0	-0.028	-1000.0
TCGA08_rtk_signaling	12.0	312.0	26.0	-0.021	0.062	1000.0	-1000.0	-0.008	-1000.0
PDGFR-beta signaling pathway	12.0	1216.0	97.0	-0.049	0.061	1000.0	-1000.0	-0.034	-1000.0
Visual signal transduction: Rods	12.0	633.0	52.0	-0.0	0.05	1000.0	-1000.0	-0.014	-1000.0
Regulation of nuclear SMAD2/3 signaling	11.0	1528.0	136.0	-0.296	0.072	1000.0	-1000.0	-0.031	-1000.0
Cellular roles of Anthrax toxin	11.0	430.0	39.0	-0.028	0.028	1000.0	-1000.0	-0.016	-1000.0
Presenilin action in Notch and Wnt signaling	11.0	685.0	61.0	-0.01	0.071	1000.0	-1000.0	-0.04	-1000.0
FOXA2 and FOXA3 transcription factor networks	11.0	543.0	46.0	-0.138	0.045	1000.0	-1000.0	-0.042	-1000.0
EPO signaling pathway	11.0	622.0	55.0	-0.009	0.048	1000.0	-1000.0	-0.011	-1000.0
PDGFR-alpha signaling pathway	11.0	527.0	44.0	-0.019	0.053	1000.0	-1000.0	-0.029	-1000.0
Canonical Wnt signaling pathway	11.0	580.0	51.0	-0.026	0.064	1000.0	-1000.0	-0.031	-1000.0
Regulation of p38-alpha and p38-beta	11.0	632.0	54.0	-0.05	0.057	1000.0	-1000.0	-0.034	-1000.0
Nongenotropic Androgen signaling	11.0	607.0	52.0	-0.057	0.047	1000.0	-1000.0	-0.016	-1000.0
Regulation of Androgen receptor activity	11.0	830.0	70.0	-0.076	0.037	1000.0	-1000.0	-0.022	-1000.0
IGF1 pathway	10.0	593.0	57.0	-0.026	0.062	1000.0	-1000.0	-0.022	-1000.0
Rapid glucocorticoid signaling	10.0	209.0	20.0	-0.009	0.028	1000.0	-1000.0	-0.009	-1000.0
Coregulation of Androgen receptor activity	9.0	717.0	76.0	-0.06	0.047	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by HDAC Class III	9.0	384.0	40.0	-0.052	0.044	1000.0	-1000.0	-0.033	-1000.0
Retinoic acid receptors-mediated signaling	9.0	549.0	58.0	-0.042	0.054	1000.0	-1000.0	-0.018	-1000.0
Atypical NF-kappaB pathway	9.0	284.0	31.0	-0.012	0.034	1000.0	-1000.0	-0.018	-1000.0
Syndecan-3-mediated signaling events	9.0	318.0	35.0	0.0	0.071	1000.0	-1000.0	-0.008	-1000.0
IL6-mediated signaling events	9.0	687.0	75.0	-0.037	0.077	1000.0	-1000.0	-0.032	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	9.0	299.0	33.0	-0.004	0.059	1000.0	-1000.0	-0.026	-1000.0
FOXM1 transcription factor network	9.0	508.0	51.0	-0.011	0.065	1000.0	-1000.0	-0.063	-1000.0
ErbB4 signaling events	8.0	597.0	69.0	-0.062	0.065	1000.0	-1000.0	-0.027	-1000.0
Hedgehog signaling events mediated by Gli proteins	8.0	540.0	65.0	-0.051	0.066	1000.0	-1000.0	-0.04	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	8.0	726.0	83.0	-0.029	0.052	1000.0	-1000.0	-0.015	-1000.0
Regulation of Telomerase	8.0	836.0	102.0	-0.085	0.055	1000.0	-1000.0	-0.025	-1000.0
Insulin Pathway	8.0	651.0	74.0	-0.077	0.068	1000.0	-1000.0	-0.03	-1000.0
Aurora B signaling	8.0	538.0	67.0	-0.059	0.064	1000.0	-1000.0	-0.036	-1000.0
Visual signal transduction: Cones	7.0	300.0	38.0	-0.016	0.049	1000.0	-1000.0	-0.015	-1000.0
Arf6 downstream pathway	7.0	340.0	43.0	-0.038	0.047	1000.0	-1000.0	-0.029	-1000.0
mTOR signaling pathway	7.0	422.0	53.0	-0.033	0.032	1000.0	-1000.0	-0.033	-1000.0
Class I PI3K signaling events mediated by Akt	7.0	490.0	68.0	-0.038	0.05	1000.0	-1000.0	-0.019	-1000.0
HIF-2-alpha transcription factor network	7.0	342.0	43.0	-0.106	0.109	1000.0	-1000.0	-0.034	-1000.0
FoxO family signaling	7.0	462.0	64.0	-0.176	0.04	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by PRL	7.0	243.0	34.0	-0.024	0.044	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	6.0	806.0	125.0	-0.017	0.064	1000.0	-1000.0	-0.024	-1000.0
p38 MAPK signaling pathway	6.0	278.0	44.0	-0.043	0.046	1000.0	-1000.0	-0.014	-1000.0
Canonical NF-kappaB pathway	5.0	208.0	39.0	-0.009	0.058	1000.0	-1000.0	-0.016	-1000.0
BARD1 signaling events	5.0	336.0	57.0	-0.053	0.059	1000.0	-1000.0	-0.044	-1000.0
PLK2 and PLK4 events	5.0	15.0	3.0	-0.018	-1000.0	1000.0	-1000.0	-0.018	-1000.0
PLK1 signaling events	5.0	441.0	85.0	-0.009	0.051	1000.0	-1000.0	-0.024	-1000.0
Insulin-mediated glucose transport	5.0	188.0	32.0	-0.022	0.05	1000.0	-1000.0	-0.018	-1000.0
Arf6 trafficking events	5.0	382.0	71.0	-0.037	0.05	1000.0	-1000.0	-0.037	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	4.0	167.0	34.0	-0.044	0.073	1000.0	-1000.0	-0.029	-1000.0
Aurora C signaling	4.0	29.0	7.0	-0.0	0.049	1000.0	-1000.0	-0.005	-1000.0
Signaling events mediated by HDAC Class I	3.0	336.0	104.0	-0.051	0.066	1000.0	-1000.0	-0.039	-1000.0
VEGFR1 specific signals	3.0	214.0	56.0	-0.031	0.052	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by HDAC Class II	2.0	218.0	75.0	-0.03	0.069	1000.0	-1000.0	-0.02	-1000.0
Circadian rhythm pathway	2.0	56.0	22.0	-0.007	0.042	1000.0	-1000.0	-0.026	-1000.0
Aurora A signaling	2.0	178.0	60.0	-0.018	0.057	1000.0	-1000.0	-0.018	-1000.0
Arf1 pathway	2.0	118.0	54.0	-0.006	0.049	1000.0	-1000.0	-0.01	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	22.0	23.0	0.004	0.055	1000.0	-1000.0	-0.013	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	11.0	27.0	-0.011	0.066	1000.0	-1000.0	-0.023	-1000.0
Alternative NF-kappaB pathway	0.0	3.0	13.0	0.0	0.072	1000.0	-1000.0	0.0	-1000.0
Total	2202	128990	7203	-7.59544158518	-993.328323425	131000	-131000	-3.14444400076	-131000