Clinical Features Time to Death AGE PRIMARY.SITE.OF.DISEASE GENDER DISTANT.METASTASIS LYMPH.NODE.METASTASIS TUMOR.STAGECODE NEOPLASM.DISEASESTAGE nMutated (%) nWild-Type logrank test_P logrank test_Q t-test_P t-test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Chi-square test_P Chi-square test_Q Chi-square test_P Chi-square test_Q t-test_P t-test_Q Chi-square test_P Chi-square test_Q CDKN2A 8 (12%) 57 0.88512 1 0.28724 1 0.73913 1 0.25917 1 0.94689 1 0.82715 1 NA NA 0.48436 1 PTEN 8 (12%) 57 0.35851 1 0.43674 1 0.38573 1 0.42014 1 0.1349 1 0.93574 1 NA NA 0.097819 1 OR4K1 7 (11%) 58 0.32233 1 0.73134 1 0.073315 1 1 1 0.96099 1 0.65554 1 NA NA 0.35225 1 RPTN 11 (17%) 54 0.36353 1 0.95721 1 0.074791 1 1 1 0.8919 1 0.58249 1 NA NA 0.091198 1 TP53 7 (11%) 58 0.43632 1 0.28702 1 0.11912 1 0.67241 1 0.30808 1 0.57501 1 NA NA 0.32797 1 ACSM2B 13 (20%) 52 0.12815 1 0.34842 1 0.23095 1 0.046327 1 0.86948 1 0.53053 1 NA NA 0.42188 1 C7ORF58 8 (12%) 57 0.98663 1 0.42067 1 1 1 1 1 0.091712 1 0.8158 1 NA NA 0.28863 1 GFRAL 7 (11%) 58 0.45251 1 0.29456 1 0.26484 1 0.41308 1 0.94689 1 0.68325 1 NA NA 0.68235 1 LILRA1 10 (15%) 55 0.88716 1 0.42186 1 0.27803 1 1 1 0.91231 1 0.37042 1 NA NA 0.57581 1 DSG3 12 (18%) 53 0.76292 1 0.6215 1 0.49296 1 1 1 0.13405 1 0.66041 1 NA NA 0.28924 1 PRAMEF11 4 (6%) 61 0.5155 1 0.081262 1 1 1 0.29578 1 0.9827 1 0.0006139 0.411 NA NA 0.48335 1 RFX6 10 (15%) 55 0.091823 1 0.22383 1 0.47175 1 0.71529 1 0.22111 1 0.94161 1 NA NA 0.61354 1 SLC4A10 10 (15%) 55 0.8337 1 0.24091 1 0.47175 1 0.27138 1 0.65977 1 0.64464 1 NA NA 0.7022 1 SERPINB4 6 (9%) 59 0.3399 1 0.76082 1 0.65861 1 0.1655 1 0.053247 1 0.25285 1 NA NA 0.60504 1 NBPF1 10 (15%) 55 0.44057 1 0.60237 1 0.68045 1 0.47929 1 0.93066 1 0.58676 1 NA NA 0.61214 1 NELL1 11 (17%) 54 0.069775 1 0.0012361 0.822 0.79593 1 0.087758 1 0.22111 1 0.28134 1 NA NA 0.58714 1 OR4C15 7 (11%) 58 0.75258 1 0.17215 1 0.010594 1 0.67241 1 0.94689 1 0.75945 1 NA NA 0.80843 1 CDR1 6 (9%) 59 0.40462 1 0.14447 1 0.24247 1 0.37876 1 0.023897 1 0.97964 1 NA NA 0.98817 1 GK2 8 (12%) 57 0.38332 1 0.20116 1 0.16036 1 0.7063 1 0.94689 1 0.81907 1 NA NA 0.17185 1 OR5D13 5 (8%) 60 0.13578 1 0.26009 1 1 1 1 1 0.97293 1 0.00066359 0.443 NA NA 0.29949 1 ZNF215 7 (11%) 58 0.54109 1 0.2114 1 0.83855 1 0.67241 1 0.52255 1 0.97189 1 NA NA 0.94733 1 MORF4 6 (9%) 59 0.54246 1 0.071584 1 0.08248 1 0.37876 1 0.99028 1 0.89959 1 NA NA 0.89168 1 PRSS1 4 (6%) 61 0.66465 1 0.092214 1 0.48992 1 0.29578 1 0.99028 1 0.96218 1 NA NA 0.6342 1 TRHR 7 (11%) 58 0.31667 1 0.1101 1 0.006669 1 1 1 0.011354 1 0.76997 1 NA NA 0.66677 1 RGS21 5 (8%) 60 0.77069 1 0.57471 1 0.59697 1 1 1 0.30808 1 0.80948 1 NA NA 0.71621 1 FUT9 5 (8%) 60 0.5033 1 0.25294 1 0.1752 1 1 1 0.97293 1 0.93826 1 NA NA 0.0050788 1 CCDC102B 9 (14%) 56 0.20912 1 0.63065 1 0.061454 1 0.45456 1 0.91231 1 0.39626 1 NA NA 0.42124 1 ST6GAL2 7 (11%) 58 0.27472 1 0.42453 1 0.56683 1 0.41308 1 0.96099 1 0.29363 1 NA NA 0.12352 1 OR11L1 5 (8%) 60 0.56033 1 0.20688 1 0.097508 1 0.65487 1 0.97293 1 0.38052 1 NA NA 0.27926 1 GIMAP4 3 (5%) 62 0.57398 1 0.99307 1 0.15014 1 0.54519 1 0.99028 1 0.94604 1 NA NA 0.91266 1 ICA1L 3 (5%) 62 0.26765 1 0.39478 1 1 1 0.54519 1 NA NA NA NA NA NA NA NA CADM2 7 (11%) 58 0.77293 1 0.52051 1 0.47401 1 0.41308 1 0.94689 1 0.8158 1 NA NA 0.35292 1 GUCA1C 3 (5%) 62 0.19468 1 0.41474 1 0.36813 1 1 1 NA NA NA NA NA NA NA NA C15ORF23 4 (6%) 61 0.76251 1 0.28746 1 0.73095 1 1 1 0.9827 1 0.95377 1 NA NA 0.89508 1 HTR3B 5 (8%) 60 0.13435 1 0.7643 1 0.76292 1 1 1 0.97293 1 0.9093 1 NA NA 0.38534 1 RGPD4 13 (20%) 52 0.04515 1 0.99335 1 0.28131 1 0.19439 1 0.8451 1 0.92548 1 NA NA 0.76658 1 PENK 5 (8%) 60 0.43028 1 0.41456 1 0.075454 1 1 1 0.97293 1 0.94737 1 NA NA 0.80145 1 RBM11 4 (6%) 61 0.56382 1 0.88222 1 0.35539 1 0.58921 1 0.18072 1 0.72523 1 NA NA 0.28897 1 WBSCR17 11 (17%) 54 0.91385 1 0.29873 1 1 1 0.011908 1 0.031619 1 0.56995 1 NA NA 0.61932 1 MORC1 12 (18%) 53 0.78927 1 0.19655 1 0.2923 1 0.084486 1 0.8919 1 0.97686 1 NA NA 0.27511 1 FAM83A 3 (5%) 62 0.53685 1 0.30168 1 1 1 0.54519 1 0.00075309 0.502 0.86773 1 NA NA NA NA SPANXN2 5 (8%) 60 0.82313 1 0.36972 1 1 1 1 1 0.97293 1 0.086118 1 NA NA 0.0074879 1 OR2M3 9 (14%) 56 0.25251 1 0.0039872 1 0.061454 1 1 1 0.59999 1 0.77499 1 NA NA 0.55148 1 TLL1 14 (22%) 51 0.37633 1 0.99517 1 0.067749 1 1 1 0.79079 1 0.40627 1 NA NA 0.080251 1 ZNF331 5 (8%) 60 0.023754 1 0.68899 1 0.097508 1 1 1 0.023897 1 0.95339 1 NA NA 0.85252 1 OR2L3 6 (9%) 59 0.36484 1 0.71368 1 0.069248 1 1 1 0.023897 1 0.9554 1 NA NA 0.33963 1 NCR1 5 (8%) 60 0.51939 1 0.035686 1 0.097508 1 0.65487 1 0.9827 1 0.90465 1 NA NA 0.58169 1 PPP6C 5 (8%) 60 0.12164 1 0.65404 1 0.34336 1 1 1 0.30808 1 0.77688 1 NA NA 0.57314 1 UGT2B15 7 (11%) 58 0.61548 1 0.22867 1 0.22265 1 0.41308 1 0.42502 1 0.92274 1 NA NA 0.17579 1 DISP1 8 (12%) 57 0.78046 1 0.039062 1 0.73913 1 0.7063 1 0.9827 1 0.90465 1 NA NA 0.71702 1 ADAM18 13 (20%) 52 0.38526 1 0.83964 1 0.34746 1 0.52199 1 0.8451 1 0.90551 1 NA NA 0.67764 1 ZNF160 6 (9%) 59 0.54618 1 0.70717 1 0.41482 1 0.65487 1 0.96099 1 0.010247 1 NA NA 0.0032476 1 MAEL 4 (6%) 61 0.97253 1 0.24171 1 0.017479 1 1 1 0.9827 1 0.72523 1 NA NA 0.44129 1 NRK 7 (11%) 58 0.35245 1 0.726 1 0.26484 1 0.67241 1 0.96099 1 0.87445 1 NA NA 0.69787 1 ADAM32 8 (12%) 57 0.19497 1 0.37381 1 0.61665 1 0.25917 1 0.94689 1 0.68325 1 NA NA 0.54035 1 SNTG1 6 (9%) 59 0.76305 1 0.23952 1 0.044713 1 1 1 0.96099 1 0.65554 1 NA NA 0.013685 1 NDST4 9 (14%) 56 0.30189 1 0.41408 1 0.25525 1 0.025908 1 0.93066 1 0.5579 1 NA NA 0.4285 1 B2M 3 (5%) 62 0.42234 1 0.93672 1 1 1 0.54519 1 NA NA NA NA NA NA NA NA RGPD3 8 (12%) 57 0.29615 1 0.065887 1 0.21047 1 0.25917 1 0.93066 1 0.51921 1 NA NA 0.2363 1 WDR12 6 (9%) 59 0.77633 1 0.67891 1 0.65861 1 0.65487 1 0.9827 1 0.41652 1 NA NA 0.96605 1 PCDP1 6 (9%) 59 0.17705 1 0.81873 1 0.41482 1 1 1 0.96099 1 0.92274 1 NA NA 0.19208 1 ZNF679 4 (6%) 61 0.7663 1 0.28824 1 0.072173 1 0.58921 1 0.9827 1 0.17576 1 NA NA 0.07135 1 NAP1L2 5 (8%) 60 0.65425 1 0.98977 1 0.075454 1 0.65487 1 0.97293 1 0.57501 1 NA NA 0.58269 1 OR4A16 5 (8%) 60 0.50849 1 0.65017 1 0.12006 1 1 1 0.0029862 1 0.58735 1 NA NA 0.026691 1 PDE1A 9 (14%) 56 0.82637 1 0.092785 1 0.089097 1 0.45456 1 0.93066 1 0.26458 1 NA NA 0.26631 1 GABRE 7 (11%) 58 0.6779 1 0.242 1 0.050708 1 0.20015 1 0.94689 1 0.6184 1 NA NA 0.25577 1 PRC1 5 (8%) 60 0.48111 1 0.18785 1 1 1 0.16583 1 0.9827 1 0.90465 1 NA NA 0.81433 1 KLHL4 4 (6%) 61 0.098164 1 0.37948 1 1 1 0.58921 1 0.99028 1 0.96997 1 NA NA 0.26927 1 BAZ2B 8 (12%) 57 0.59825 1 0.52212 1 0.094076 1 0.42014 1 0.52255 1 0.14884 1 NA NA 0.1879 1 CYP4Z1 5 (8%) 60 0.042228 1 0.98726 1 0.34336 1 0.65487 1 0.023897 1 0.11937 1 NA NA 0.26927 1 C1ORF168 10 (15%) 55 0.86135 1 0.66148 1 0.18912 1 0.71529 1 0.91231 1 0.91885 1 NA NA 0.084771 1 FAM65C 7 (11%) 58 0.18749 1 0.17891 1 0.11912 1 1 1 0.96099 1 0.98437 1 NA NA 0.30251 1 NOTCH2NL 5 (8%) 60 0.83892 1 0.20333 1 1 1 0.16583 1 0.9827 1 0.41652 1 NA NA 0.54174 1 TRHDE 11 (17%) 54 0.28631 1 0.087139 1 0.25908 1 1 1 0.70501 1 0.47964 1 NA NA 0.63884 1 USP17L2 6 (9%) 59 0.62105 1 0.86156 1 0.015012 1 1 1 0.96099 1 0.95479 1 NA NA 0.7217 1 RXFP2 7 (11%) 58 0.59081 1 0.54062 1 0.69678 1 1 1 0.97293 1 0.50745 1 NA NA 0.27274 1 TAF1A 3 (5%) 62 0.61049 1 0.76913 1 1 1 1 1 0.00075309 0.502 0.49449 1 NA NA NA NA ANO4 10 (15%) 55 0.59808 1 0.44011 1 0.1684 1 0.47929 1 0.91231 1 0.59416 1 NA NA 0.81446 1 MNDA 7 (11%) 58 0.42778 1 0.01252 1 0.050708 1 0.41308 1 0.96099 1 0.95479 1 NA NA 0.35599 1 ADAM7 10 (15%) 55 0.10362 1 0.10108 1 0.077476 1 1 1 0.70501 1 0.56826 1 NA NA 0.71463 1 FOLH1B 4 (6%) 61 0.071995 1 0.37653 1 0.73095 1 1 1 0.9827 1 0.41652 1 NA NA 0.47859 1 C10ORF71 8 (12%) 57 0.45081 1 0.46754 1 0.5091 1 0.046338 1 0.96099 1 0.6147 1 NA NA 0.43565 1 CXCR2 3 (5%) 62 0.33771 1 0.78299 1 0.22596 1 1 1 0.99028 1 0.45052 1 NA NA 0.24787 1 OR4E2 5 (8%) 60 0.99755 1 0.35379 1 0.1752 1 1 1 0.30808 1 0.94737 1 NA NA 0.45815 1 POTEG 6 (9%) 59 0.72841 1 0.076499 1 0.044713 1 0.65487 1 0.023897 1 0.71184 1 NA NA 0.9012 1 TCEB3C 7 (11%) 58 0.60358 1 0.33972 1 0.69678 1 0.41308 1 0.94689 1 0.032193 1 NA NA 0.32433 1 TCP10L2 3 (5%) 62 0.023889 1 0.38163 1 0.65247 1 1 1 NA NA NA NA NA NA NA NA BAGE2 4 (6%) 61 0.55972 1 0.86056 1 0.094594 1 0.58921 1 0.18072 1 0.16827 1 NA NA 0.26493 1 CLEC14A 5 (8%) 60 0.34032 1 0.95767 1 0.22482 1 0.65487 1 0.9827 1 0.12874 1 NA NA 0.38814 1 SLC6A13 7 (11%) 58 0.77255 1 0.62091 1 0.01411 1 0.20015 1 0.42502 1 0.65554 1 NA NA 0.12691 1 BCLAF1 10 (15%) 55 0.90936 1 0.13185 1 0.1684 1 0.47929 1 0.1349 1 0.70912 1 NA NA 0.80843 1 UPF2 8 (12%) 57 0.46753 1 0.39425 1 0.86638 1 0.42014 1 0.96099 1 0.65554 1 NA NA 0.65749 1 GPR141 6 (9%) 59 0.92048 1 0.20309 1 1 1 0.65487 1 0.96099 1 0.90395 1 NA NA 0.67487 1 ZNF334 4 (6%) 61 0.57055 1 0.43992 1 0.24533 1 1 1 NA NA NA NA NA NA NA NA HAPLN1 4 (6%) 61 0.17049 1 0.15856 1 1 1 1 1 0.0067749 1 0.96058 1 NA NA 0.30139 1 MUM1L1 7 (11%) 58 0.1867 1 0.67106 1 1 1 1 1 0.94689 1 0.97189 1 NA NA 0.60406 1 ST18 7 (11%) 58 0.52535 1 0.78677 1 1 1 0.67241 1 0.97293 1 0.50745 1 NA NA 0.72549 1 OR5H15 5 (8%) 60 0.86827 1 0.47063 1 1 1 0.16583 1 0.97293 1 0.38052 1 NA NA 0.21503 1