rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(5), CD4(5), HLA-DRA(3), HLA-DRB1(1), IL1B(2), IL5(1), IL5RA(3) 761782 21 19 20 4 15 1 0 4 1 0 0.0101 0.0304 1.000 2 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(2), F13B(7), HSD17B2(3), HSD17B4(4), HSD3B1(3), HSD3B2(3) 1145924 22 20 21 3 16 0 2 2 1 1 0.00703 0.0342 1.000 3 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(3), DCN(7), KERA(2), LUM(4) 506483 16 13 16 4 11 2 0 0 3 0 0.0323 0.0600 1.000 4 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(5), HLA-DRA(3), HLA-DRB1(1) 334543 9 8 9 0 5 1 0 3 0 0 0.0192 0.0774 1.000 5 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(1), FOSB(2), GRIA2(14) 526332 17 13 17 4 12 2 1 1 1 0 0.0869 0.0794 1.000 6 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(4), GOT1(3), GOT2(1), TAT(4), TYR(4) 673736 16 13 16 3 10 2 1 1 2 0 0.0589 0.106 1.000 7 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(5), CD80(3), HLA-DRA(3), HLA-DRB1(1), IL10(1) 562026 13 9 13 1 5 1 1 6 0 0 0.0360 0.129 1.000 8 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(3), PIK3CA(3), PIK3R1(3), PLCB1(16), PLCG1(6), PRKCA(2), VAV1(5) 1832035 38 28 38 6 24 1 2 6 4 1 0.00265 0.144 1.000 9 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(3) 102790 3 3 3 1 2 0 1 0 0 0 0.541 0.162 1.000 10 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(8) 260514 10 6 10 2 6 1 1 2 0 0 0.159 0.176 1.000 11 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CDO1(2), CSAD(2), GAD1(5), GAD2(4), GGT1(2) 808113 17 14 17 3 12 3 0 1 1 0 0.0215 0.208 1.000 12 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(1), NFKBIA(1), PLCB1(16), PRKCA(2), RELA(2) 1171951 23 17 23 3 14 1 2 3 3 0 0.0152 0.244 1.000 13 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(3), GOT2(1), TAT(4) 377080 8 6 8 0 5 1 1 1 0 0 0.0282 0.246 1.000 14 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD4(5), FYN(1), HLA-DRA(3), HLA-DRB1(1), LCK(1), PTPRC(16) 1262907 27 20 26 6 17 4 1 4 1 0 0.0259 0.284 1.000 15 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCR3(5), HLA-DRA(3), HLA-DRB1(1), IL3(2), IL5(1) 432318 13 12 13 4 10 0 0 3 0 0 0.108 0.287 1.000 16 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A2(3), BCMO1(4) 559215 7 7 7 1 5 1 0 1 0 0 0.136 0.404 1.000 17 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIPT1(2) 220911 2 2 2 0 0 1 0 1 0 0 0.634 0.458 1.000 18 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(2), ACP2(2), ACP5(2), ACPP(3), ENPP1(4), ENPP3(4), FLAD1(3), TYR(4) 1383691 24 19 24 3 14 3 0 4 3 0 0.0159 0.473 1.000 19 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(3), NR0B2(1), NR1H3(2), NR1H4(5) 776226 11 10 11 2 5 2 2 1 1 0 0.0813 0.479 1.000 20 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH6(3), ADH7(5) 809092 27 21 25 9 21 3 1 2 0 0 0.145 0.513 1.000 21 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(3) 441175 5 5 5 2 2 0 1 1 1 0 0.548 0.523 1.000 22 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(2), ALDOB(2), ALDOC(2) 563762 6 5 6 1 3 2 0 0 1 0 0.165 0.542 1.000 23 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 73504 1 1 1 0 1 0 0 0 0 0 0.677 0.545 1.000 24 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(2), ACP2(2), ACP5(2), ACP6(2), ACPP(3), ALPI(4), ALPL(1), ALPP(2), ALPPL2(1), CMBL(1), CYP3A4(8), CYP3A43(7), CYP3A5(5), CYP3A7(1), DHRS1(1), DHRS2(3), DHRS3(2), DHRS7(1), PON1(3), PON3(1) 2560723 52 34 50 5 40 6 2 3 1 0 3.84e-07 0.561 1.000 25 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(5), CYP2E1(5), NR1I3(2), PTGS1(7), PTGS2(2) 768046 21 15 21 7 15 2 1 2 1 0 0.0796 0.562 1.000 26 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(5), CYP2A13(1), CYP2A6(3), CYP2A7(3), NAT1(1), NAT2(5), XDH(8) 1144988 26 20 24 9 17 2 4 1 2 0 0.0341 0.568 1.000 27 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(5), CD8A(1), CSF1(4), EPO(2), IL3(2), IL5(1), IL7(2) 860920 17 13 17 4 13 1 0 1 2 0 0.0198 0.569 1.000 28 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1), SLPI(1) 245541 2 2 2 0 0 0 0 2 0 0 0.702 0.599 1.000 29 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADM(1), ECHS1(1), HADHA(4) 785992 6 6 6 1 1 2 0 3 0 0 0.448 0.618 1.000 30 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(5), GAD1(5), HDC(6), TH(4), TPH1(2) 846272 22 18 22 8 19 0 0 2 1 0 0.0727 0.625 1.000 31 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 EPO(2), FLT3(10), IGF1(5), IL1A(1), IL3(2), TGFB3(2) 1174354 22 17 22 6 14 1 1 4 2 0 0.0653 0.653 1.000 32 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD4(5) 457899 5 4 5 2 3 1 0 1 0 0 0.450 0.674 1.000 33 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(1), ECHS1(1), EHHADH(2), GCDH(3), HADHA(4), SDHB(1) 1114627 12 10 12 3 8 2 0 2 0 0 0.179 0.708 1.000 34 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(6), CD4(5), CD8A(1), IL3(2) 876869 14 10 13 3 12 1 0 1 0 0 0.0496 0.714 1.000 35 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(1), IFNGR1(1), IFNGR2(2), JAK1(2), JAK2(2) 1167190 8 8 8 1 2 0 0 2 4 0 0.442 0.715 1.000 36 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(2) 236827 2 2 2 0 2 0 0 0 0 0 0.344 0.715 1.000 37 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), GSS(2), NFKB1(1), NOX1(3), RELA(2), XDH(8) 1409482 17 15 17 3 10 3 2 2 0 0 0.0315 0.721 1.000 38 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), ECHS1(1), EHHADH(2), HADHA(4) 690225 8 8 8 3 3 2 0 3 0 0 0.500 0.722 1.000 39 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 FOS(1), JUN(1), KEAP1(1), MAPK1(1), MAPK14(2), NFE2L2(1), PRKCA(2) 1258819 9 9 9 1 4 0 0 2 3 0 0.187 0.728 1.000 40 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(1), SNAP25(2), STX1A(1) 468277 4 4 4 1 3 0 0 0 1 0 0.372 0.739 1.000 41 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(7), RANGAP1(1) 1216644 9 9 9 1 4 1 1 2 1 0 0.215 0.770 1.000 42 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(3), FUT1(1), FUT3(1), FUT5(3), FUT6(3), ST3GAL3(1) 710421 12 11 12 5 7 1 0 1 3 0 0.188 0.771 1.000 43 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(2), ESR2(3), PDE1A(13), PDE1B(5), PLCB1(16), PLCB2(1), TRH(3), VIP(1) 1567771 44 25 43 12 33 1 2 6 2 0 0.00747 0.785 1.000 44 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), BCKDK(1), CBS(1), CTH(1), MUT(2) 728346 6 6 6 2 4 1 1 0 0 0 0.483 0.792 1.000 45 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(2), IFNAR1(1), IFNAR2(5), IFNB1(2), NFKB1(1), RELA(2), TNFRSF11A(2), TNFSF11(2), TRAF6(1) 1581441 19 13 19 2 8 2 0 6 3 0 0.0235 0.803 1.000 46 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNAQ(1), HTR2C(3), PLCB1(16), TUB(2) 1020010 22 14 22 4 16 0 1 3 2 0 0.0202 0.804 1.000 47 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), CS(1), ME1(8), PC(7), PDHA1(1) 1329486 19 13 18 3 9 0 2 6 2 0 0.0299 0.813 1.000 48 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(4), PARK2(2), SNCA(1), SNCAIP(14), UBE2F(1), UBE2L6(1) 919757 23 18 22 8 14 3 1 2 3 0 0.232 0.816 1.000 49 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), GPR161(1), GPR171(4), GPR18(3), GPR39(2), GPR45(1), GPR65(4), GPR68(1), GPR75(2) 1395089 20 18 20 6 11 0 2 3 4 0 0.0308 0.820 1.000 50 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(2), CPS1(5), GLS(1), GOT1(3) 1098641 12 11 12 3 6 1 2 3 0 0 0.237 0.826 1.000 51 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP2(3), RECK(8), TIMP3(2), TIMP4(3) 1060539 16 14 16 4 10 0 1 4 1 0 0.149 0.842 1.000 52 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(2), ACP2(2), ACP5(2), ACP6(2), ACPP(3), ENPP1(4), ENPP3(4), FLAD1(3), MTMR1(2), MTMR2(1), TYR(4) 2143531 29 21 29 3 16 3 2 5 3 0 0.00514 0.843 1.000 53 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(3), AASS(2) 669262 6 6 6 1 5 0 0 1 0 0 0.324 0.851 1.000 54 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(1), HMGCS1(1), HMGCS2(5), OXCT1(2), OXCT2(1) 1021301 10 7 10 2 5 1 0 3 1 0 0.205 0.863 1.000 55 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB11A(1), RAB1A(1), RAB5A(1) 600876 3 3 3 1 1 1 1 0 0 0 0.569 0.866 1.000 56 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(3), CHUK(1), GH1(2), GHR(8), NFKB1(1), NFKBIA(1), PDPK1(1), PIK3CA(3), PIK3R1(3), RELA(2) 1994562 25 19 24 6 13 2 1 6 2 1 0.122 0.867 1.000 57 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(1), ERBB4(15), NRG2(3), NRG3(5), PRKCA(2), PSEN1(1) 1267339 27 21 26 8 18 1 1 3 4 0 0.136 0.870 1.000 58 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), ECHS1(1), EHHADH(2), HADHA(4), HSD17B10(2), HSD17B4(4), SIRT5(1), SIRT7(1), VNN2(1) 1688436 17 16 17 4 8 3 2 4 0 0 0.162 0.874 1.000 59 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(3), FOS(1), JUN(1), MAP2K1(3), MAPK1(1), NFKB1(1), NFKBIA(1), PLCB1(16), PRKCA(2), RAF1(3), RELA(2) 2221062 34 24 31 9 21 2 3 5 3 0 0.0306 0.882 1.000 60 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(4), COASY(1), DPYD(17), DPYS(12), ENPP1(4), ENPP3(4), PANK2(1), PANK3(1), PANK4(3), UPB1(2) 1984906 49 30 47 11 31 3 2 9 4 0 0.0173 0.885 1.000 61 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(2), MTMR2(1), TPK1(3) 914167 6 5 5 0 2 0 1 1 1 1 0.178 0.886 1.000 62 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(1), DPM2(1), KLK2(1), MAP2K1(3), MAP2K2(2), MAPK1(1), RAF1(3) 1153485 12 12 10 4 6 0 1 3 2 0 0.325 0.887 1.000 63 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CSF1(4), LDLR(3), LPL(1) 765704 8 7 8 0 6 0 0 1 1 0 0.0225 0.888 1.000 64 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(1), OXCT1(2) 481726 3 3 3 1 2 0 0 0 1 0 0.572 0.893 1.000 65 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SEC61A2(5), SRP19(3), SRP54(1), SRP68(1), SRPR(1) 1092702 12 9 12 4 3 0 2 4 3 0 0.726 0.898 1.000 66 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(5), CSF1(4), HLA-DRA(3), HLA-DRB1(1), IFNA1(1), IFNB1(2), IFNG(1), IL10(1), IL15(1), IL1A(1), IL3(2), IL5(1), IL7(2), PDGFA(1), TGFB3(2) 1869941 28 17 28 6 16 1 1 4 6 0 0.00465 0.901 1.000 67 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 11 CCNA1(8), CCNE1(1), CCNE2(5), E2F2(1), PRB1(7) 1106279 22 16 21 5 15 0 1 6 0 0 0.120 0.906 1.000 68 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(2), AASDHPPT(3), AASS(2) 990730 8 7 8 1 6 0 0 1 1 0 0.198 0.913 1.000 69 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(1), UGDH(1), UXS1(2) 551755 4 4 4 2 3 0 0 0 1 0 0.612 0.914 1.000 70 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(4), CTH(1), GOT1(3), GOT2(1), LDHA(1), LDHB(2), LDHC(2) 980656 14 11 14 3 9 0 3 2 0 0 0.102 0.915 1.000 71 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(4), IARS(2), LARS(3), PDHA1(1), PDHA2(6) 1441176 16 14 16 2 13 1 0 1 1 0 0.0330 0.924 1.000 72 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(3), EPHX2(1), HSD3B7(2), RDH11(1), RDH12(1), RDH13(1) 686159 9 7 9 4 6 1 0 1 1 0 0.288 0.924 1.000 73 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(3), MBTPS1(4), MBTPS2(1), SCAP(5), SREBF1(1), SREBF2(1) 1686111 16 14 16 1 9 0 2 4 1 0 0.0115 0.924 1.000 74 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(1) 302966 1 1 1 1 1 0 0 0 0 0 0.835 0.926 1.000 75 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), FARSA(2), FARSB(1), GOT1(3), GOT2(1), PAH(3), TAT(4), YARS2(1) 1244837 16 13 15 4 12 2 1 1 0 0 0.0678 0.927 1.000 76 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(3), DPM2(1), GRB2(1), KLK2(1), NTRK1(5), PIK3CA(3), PIK3R1(3), PLCG1(6), PRKCA(2), SOS1(3) 2212990 28 21 28 7 14 3 1 6 3 1 0.124 0.927 1.000 77 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 9 ECHS1(1), HADHA(4), HSD17B10(2), HSD17B4(4), MECR(1), PPT1(2) 1116287 14 13 14 5 6 4 2 2 0 0 0.431 0.942 1.000 78 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(3), DHRS1(1), DHRS2(3), DHRS3(2), DHRS7(1), HSD3B7(2), PON1(3), PON3(1), RDH11(1), RDH12(1), RDH13(1) 1289361 19 16 19 6 14 3 0 1 1 0 0.0641 0.942 1.000 79 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(12), GNAS(5), PRKACA(2), PRKAR1A(1) 924777 20 12 20 6 11 2 3 1 3 0 0.122 0.943 1.000 80 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(4), GGT1(2), SHMT1(1) 580887 7 7 7 4 4 1 0 1 1 0 0.569 0.945 1.000 81 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 IFNG(1) 423529 1 1 1 1 0 0 0 0 1 0 0.847 0.946 1.000 82 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(5), CAPN1(2), CDK5(1), CSNK1A1(1), GSK3B(1), MAPT(1) 1283206 11 11 11 2 10 1 0 0 0 0 0.0605 0.952 1.000 83 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(4), ALPL(1), ALPP(2), ALPPL2(1), SPR(1) 904413 9 8 8 4 6 1 1 1 0 0 0.396 0.954 1.000 84 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 CHAT(3), CHKA(1), PCYT1A(1), PDHA1(1), PDHA2(6), PEMT(1) 972350 13 12 13 5 9 1 0 1 2 0 0.237 0.955 1.000 85 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 PLCG1(6), PRKCA(2), PTK2B(4) 962868 12 10 12 3 7 1 1 2 1 0 0.139 0.955 1.000 86 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP3(1), CASP8(4), CFL1(1), PDE6D(1) 556827 7 6 7 3 3 0 1 3 0 0 0.676 0.957 1.000 87 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(4), COASY(1), DPYD(17), DPYS(12), ENPP1(4), ENPP3(4), ILVBL(1), PANK2(1), PANK3(1), PANK4(3), UPB1(2), VNN1(4) 2462862 54 31 52 12 36 3 2 9 4 0 0.00579 0.958 1.000 88 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(1), ENO2(1), ENO3(1), FARS2(1), GOT1(3), GOT2(1), PAH(3), TAT(4) 1193388 15 13 15 4 11 1 1 2 0 0 0.0897 0.961 1.000 89 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(3), CAT(1), GH1(2), GHR(8), IGF1(5), IGF1R(4), PIK3CA(3), PIK3R1(3) 1889508 29 23 28 9 21 1 0 4 2 1 0.124 0.962 1.000 90 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(3), BIRC3(3), CASP8(4) 1166737 10 10 10 3 5 0 2 3 0 0 0.357 0.963 1.000 91 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ5(1), COQ7(1), NDUFA12(1), NDUFA13(1) 568287 4 4 4 2 3 1 0 0 0 0 0.726 0.965 1.000 92 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFB2(1), NDUFB5(1), NDUFB6(1), NDUFV1(2) 998428 5 5 5 0 3 0 1 1 0 0 0.160 0.968 1.000 93 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(5), GABRA2(8), GABRA3(7), GABRA4(4), GABRA6(8), GPX1(1), PRKCE(2) 1107230 35 27 31 13 28 0 1 3 2 1 0.0925 0.974 1.000 94 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(6), GNA12(1), PRKACB(3), PRKACG(3), PRKAG1(1), PRKAR2A(1), PRKAR2B(1) 1438973 16 13 16 4 9 1 0 4 2 0 0.227 0.975 1.000 95 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(3), HLA-DRA(3), HLA-DRB1(1), IFNG(1), IFNGR1(1), IFNGR2(2), IL12RB1(3), IL18R1(4), IL2RA(1), IL4R(6) 1803579 25 18 25 8 15 0 0 5 5 0 0.222 0.976 1.000 96 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 11 ARPC2(1), ARPC4(1), CDC42(2), WASF1(2), WASL(1) 1101552 7 6 7 2 2 1 0 1 3 0 0.450 0.978 1.000 97 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(1), ADORA2A(1), ADORA3(3), P2RY1(1), P2RY6(1) 848027 7 7 7 4 4 2 0 1 0 0 0.376 0.980 1.000 98 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL2(1), ST6GALNAC2(1), ST8SIA1(1) 808097 5 5 5 1 5 0 0 0 0 0 0.173 0.980 1.000 99 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(1), IFNAR2(5), IFNB1(2), JAK1(2), STAT2(4), TYK2(1) 1537590 16 12 16 4 5 1 1 5 4 0 0.228 0.983 1.000 100 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(5), ACOX3(3), FADS2(2), PLA2G2D(2), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2) 1442314 21 19 21 8 15 2 0 2 2 0 0.172 0.983 1.000 101 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(2), IL4R(6), JAK1(2), JAK2(2), TYK2(1) 1491565 14 14 14 4 9 0 0 3 2 0 0.316 0.983 1.000 102 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(2), IL4R(6), JAK1(2), JAK2(2), TYK2(1) 1491565 14 14 14 4 9 0 0 3 2 0 0.316 0.983 1.000 103 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 IFNG(1), IL2RA(1), TGFB3(2), TGFBR2(2), TGFBR3(1), TOB2(1) 1504114 8 8 8 1 5 0 0 1 2 0 0.102 0.985 1.000 104 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(2), LPL(1), PPARG(4), RETN(1) 832917 8 7 8 3 6 0 0 2 0 0 0.438 0.986 1.000 105 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 21 AKT1(3), EIF4A1(1), EIF4A2(2), EIF4G1(2), EIF4G2(1), EIF4G3(4), GHR(8), IRS1(1), MAPK1(1), MAPK14(2), MKNK1(2), PABPC1(2), PDK2(2), PDPK1(1), PIK3CA(3), PIK3R1(3), PRKCA(2) 3914439 40 31 39 8 23 3 1 6 6 1 0.0206 0.987 1.000 106 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(4), CKM(1), GPT(1), LDHA(1), LDHB(2), LDHC(2), MAPK14(2), NCL(3) 1279681 16 14 16 6 9 1 2 2 2 0 0.332 0.990 1.000 107 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), MAPK14(2), NFKB1(1), RELA(2), TNFRSF13B(1), TNFRSF17(1), TRAF3(2), TRAF5(2), TRAF6(1) 2046586 13 13 13 4 5 3 0 4 1 0 0.359 0.990 1.000 108 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(1), DRD1(1), DRD2(7), GRM1(4), PLCB1(16), PPP3CA(4), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1) 2273760 43 27 42 11 30 1 2 5 5 0 0.00572 0.991 1.000 109 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(4), GZMB(1), ITGAL(6), ITGB2(2) 1236394 13 12 13 6 6 2 0 2 3 0 0.462 0.991 1.000 110 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(2), B4GALT1(1), B4GALT2(1), B4GALT3(1), FUT8(2), ST3GAL2(1), ST3GAL3(1) 1118931 9 8 9 3 6 1 1 0 1 0 0.328 0.992 1.000 111 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 20 AKT1(3), CDC42(2), CHUK(1), ELK1(1), H2AFX(2), MAP2K1(3), NFKB1(1), PIK3CA(3), PIK3R1(3), RAF1(3), RALA(1), RALGDS(2), RELA(2), RHOA(1) 2627321 28 22 26 9 13 4 1 7 2 1 0.219 0.992 1.000 112 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(2), ITGA4(10), ITGAL(6), ITGAM(3), ITGB1(1), ITGB2(2), SELE(4), SELL(3), SELP(11) 2257263 42 30 40 11 32 2 1 5 2 0 0.0206 0.992 1.000 113 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(1), EIF2S1(1), NFKB1(1), NFKBIA(1), RELA(2) 1264420 6 6 6 2 1 2 1 2 0 0 0.573 0.992 1.000 114 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 12 CDKN1A(1), CFL1(1), E2F2(1), MDM2(2), PRB1(7) 909685 12 9 11 4 7 1 0 4 0 0 0.446 0.993 1.000 115 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(3), ARG1(1), ASL(2), CKM(1), CKMT2(2), CPS1(5), GAMT(1), GATM(2), ODC1(3), OTC(1), SMS(4) 2462958 25 21 25 7 11 3 2 5 4 0 0.0927 0.993 1.000 116 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(4), DUSP14(1), HBEGF(1), IFNG(1), IFRD1(2), IL1A(1), IL1R1(2), WDR1(1) 1515518 13 12 13 6 6 2 0 1 4 0 0.671 0.993 1.000 117 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(1), SULT1E1(2), SULT2A1(1) 871700 4 4 4 3 2 0 0 0 2 0 0.791 0.993 1.000 118 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(4), IL1B(2) 930249 6 6 5 2 5 0 0 0 1 0 0.308 0.994 1.000 119 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), CREBBP(4), DFFA(1), GZMA(4), GZMB(1) 1509478 11 9 11 3 5 0 1 4 1 0 0.405 0.994 1.000 120 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1) 647268 1 1 1 0 0 0 0 1 0 0 0.839 0.994 1.000 121 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(2), ITGAL(6), ITGAM(3), ITGB2(2), SELE(4), SELL(3) 1466131 20 18 20 8 14 2 1 2 1 0 0.242 0.994 1.000 122 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 SDHB(1), UQCRC1(2) 949980 3 3 3 1 1 0 1 0 1 0 0.552 0.994 1.000 123 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYB(2), NFYC(1), RB1(2) 953539 5 3 5 2 0 0 0 4 0 1 0.819 0.994 1.000 124 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PRKCA(2) 707833 2 2 2 1 1 0 0 0 1 0 0.707 0.995 1.000 125 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(1), IDI1(1), SQLE(2) 455136 4 4 4 3 1 1 1 1 0 0 0.837 0.995 1.000 126 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 AKT1(3), ANXA1(3), CALM2(1), GNAS(5), NFKB1(1), NOS3(6), NPPA(1), PIK3CA(3), PIK3R1(3), RELA(2), SYT1(8) 2539284 36 26 35 10 24 2 2 6 1 1 0.0761 0.996 1.000 127 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(5), HK1(2), HK2(4), HK3(3), IMPA1(1), PGM1(3) 1456061 18 13 18 6 14 0 1 2 1 0 0.133 0.996 1.000 128 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(3), GRB2(1), IGF1R(4), IRS1(1), MAP2K1(3), MAPK1(1), PIK3CA(3), PIK3R1(3), RAF1(3), SOS1(3) 2709660 25 22 23 8 14 2 1 4 3 1 0.249 0.996 1.000 129 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(9), C5(4), C6(21), C7(11), C8A(8), C9(4) 1785640 57 35 56 20 43 1 1 7 5 0 0.0833 0.996 1.000 130 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 DAG1(1), GNAQ(1), ITPKB(1) 854169 3 3 3 0 1 0 1 0 1 0 0.427 0.996 1.000 131 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(1), UGDH(1), UXS1(2) 703590 4 4 4 3 3 0 0 0 1 0 0.793 0.996 1.000 132 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(2), FDPS(1), HMGCR(5), HMGCS1(1), IDI1(1), MVD(1), NSDHL(2), SC4MOL(2), SC5DL(1), SQLE(2) 1879299 18 15 18 6 3 5 2 5 3 0 0.373 0.996 1.000 133 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(6), CD4(5), ITGAL(6), ITGB2(2), PTPRC(16) 1591479 35 22 33 13 26 4 1 3 1 0 0.0632 0.997 1.000 134 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(3), AKT2(2), AKT3(1), CDKN1A(1), ELK1(1), GRB2(1), MAP2K1(3), MAP2K2(2), NTRK1(5), PIK3CA(3), PIK3CD(3), SOS1(3) 2266442 28 21 26 9 13 3 0 9 3 0 0.277 0.997 1.000 135 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(1), GGPS1(1), IDI1(1), SQLE(2) 607803 5 5 5 3 2 1 1 1 0 0 0.739 0.997 1.000 136 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(2), C1R(3), C1S(3), C2(3), C3(9), C5(4), C6(21), C7(11), C8A(8), C9(4) 2479178 68 39 66 23 50 3 1 9 5 0 0.0362 0.997 1.000 137 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(3), ABAT(1), ADSL(1), ADSS(2), AGXT(7), AGXT2(5), ASL(2), ASNS(3), CAD(4), DDO(3), GAD1(5), GAD2(4), GOT1(3), GOT2(1), GPT(1), NARS(1), PC(7) 3726030 53 39 52 14 33 6 4 7 3 0 0.00379 0.997 1.000 138 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(1), DFFA(1), GZMB(1), HMGB1(1), TOP2A(2), TOP2B(5) 1278316 11 9 11 3 8 0 0 2 1 0 0.416 0.997 1.000 139 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 6 ABO(3), B3GNT1(2), FUT1(1), ST8SIA1(1) 754482 7 7 7 4 6 0 1 0 0 0 0.483 0.997 1.000 140 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(2), ENO1(1), GPI(1), HK1(2), PFKL(2), PGK1(3), PKLR(2) 1302002 13 9 13 3 6 3 0 3 1 0 0.0987 0.997 1.000 141 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(1), CUL1(2), NEDD8(1), RB1(2) 1224951 6 6 6 7 0 0 1 3 1 1 0.991 0.997 1.000 142 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNG(1), IFNGR1(1), JAK1(2), JAK2(2), PTPRU(2), REG1A(2) 1628892 12 12 12 5 6 0 0 2 4 0 0.616 0.998 1.000 143 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(2), JAK2(2), JAK3(1), PIAS1(3), PIAS3(2), PTPRU(2), REG1A(2), SOAT1(3) 1948115 19 18 19 7 12 1 1 3 2 0 0.350 0.998 1.000 144 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(3), HS3ST1(3), HS3ST2(1), HS3ST3A1(1), HS3ST3B1(1), XYLT1(2), XYLT2(1) 903900 12 11 12 9 5 3 1 1 2 0 0.664 0.998 1.000 145 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(3), HS3ST1(3), HS3ST2(1), HS3ST3A1(1), HS3ST3B1(1), XYLT1(2), XYLT2(1) 903900 12 11 12 9 5 3 1 1 2 0 0.664 0.998 1.000 146 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 IL5(1), MAP2K3(4), MAPK14(2), NFATC1(5), NFATC2(2), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1) 1715392 24 16 24 9 15 2 0 3 4 0 0.203 0.998 1.000 147 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(5), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCA(2) 1347468 18 16 18 8 12 0 1 1 4 0 0.568 0.998 1.000 148 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1D1(7), CYP11A1(6), CYP11B1(4), CYP11B2(2), CYP17A1(2), CYP21A2(4), HSD11B1(2), HSD3B1(3), HSD3B2(3) 1399838 33 25 33 15 21 5 1 4 2 0 0.115 0.998 1.000 149 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1D1(7), CYP11A1(6), CYP11B1(4), CYP11B2(2), CYP17A1(2), CYP21A2(4), HSD11B1(2), HSD3B1(3), HSD3B2(3) 1399838 33 25 33 15 21 5 1 4 2 0 0.115 0.998 1.000 150 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(3), ACO2(1), IDH1(3), IDH2(1), MDH2(1), SDHB(1) 1281300 10 6 8 2 7 0 0 2 1 0 0.170 0.998 1.000 151 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(2), C1R(3), C1S(3), C2(3), C3(9), C5(4), C6(21), C7(11), C8A(8), C8B(14), C9(4), MASP1(1) 2949646 83 42 80 27 60 4 3 11 5 0 0.0133 0.998 1.000 152 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(3), ACO2(1), CS(1), GRHPR(1), HAO1(1), HAO2(1), MDH2(1), MTHFD1(3) 1826534 12 9 11 3 5 0 2 3 2 0 0.228 0.998 1.000 153 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 20 ABO(3), B3GNT1(2), B3GNT2(1), B3GNT3(3), B3GNT4(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), B4GALT4(1), FUT1(1), FUT3(1), FUT5(3), FUT6(3), ST8SIA1(1) 2169869 23 18 23 8 17 0 1 1 4 0 0.0935 0.998 1.000 154 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 DPM2(1), ELK1(1), FOS(1), GRB2(1), JUN(1), KLK2(1), MAP2K1(3), PIK3CA(3), PIK3R1(3), PLCG1(6), RAF1(3), SOS1(3) 2707672 27 21 25 9 14 1 2 7 2 1 0.336 0.998 1.000 155 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(1), FOS(1), FYN(1), JUN(1), MAPK14(2), THBS1(8) 1056380 14 10 14 7 7 1 0 4 2 0 0.675 0.998 1.000 156 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), CASP8AP2(3), CES1(3) 1547502 7 6 7 2 3 1 0 2 1 0 0.576 0.999 1.000 157 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), BET1L(1), GOSR1(1), SEC22B(1), SNAP25(2), SNAP29(1), STX10(1), STX11(1), STX12(1), STX17(1), STX19(1), STX3(1), STX5(4), STX6(1), TSNARE1(2), VAMP1(1), VAMP3(1), VAMP7(3) 2358932 25 18 25 7 11 3 1 4 6 0 0.127 0.999 1.000 158 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA3(4), GGT1(2), SHMT1(1) 766230 7 7 7 6 4 1 0 1 1 0 0.817 0.999 1.000 159 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(3), CHST12(1), CHST13(1), PAPSS1(1), SULT1A1(2), SULT1E1(2), SULT2A1(1), SULT2B1(3) 1296044 14 13 14 9 10 0 0 1 3 0 0.734 0.999 1.000 160 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(5), HK1(2), HK2(4), HK3(3), IMPA1(1), IMPA2(1), PGM1(3) 1656375 19 14 19 8 14 0 1 2 2 0 0.226 0.999 1.000 161 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ARPC2(1), ARPC4(1), CDC42(2), PAK1(2), PDGFRA(5), PIK3CA(3), PIK3R1(3), WASL(1) 1860559 18 14 18 7 9 1 1 3 3 1 0.539 0.999 1.000 162 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(2), ITGA4(10), ITGAL(6), ITGB1(1), ITGB2(2), SELE(4), SELL(3) 1718349 28 23 28 10 20 2 1 4 1 0 0.230 0.999 1.000 163 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 18 AKT1(3), EIF2S1(1), GSK3B(1), IGF1(5), IGF1R(4), INPPL1(5), PDK2(2), PDPK1(1), PIK3CA(3), PIK3R1(3) 2682557 28 23 28 9 16 3 1 5 2 1 0.176 0.999 1.000 164 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(12), F2(2), F2R(1), F2RL3(2), GNA12(1), GNAI1(1), GNAQ(1), PIK3CA(3), PIK3R1(3), PLCB1(16), PPP1R12B(4), PRKCA(2), PTK2B(4), ROCK1(2) 3682219 54 32 54 14 30 3 3 10 7 1 0.0168 0.999 1.000 165 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), GRB2(1), IL4R(6), IRS1(1), JAK1(2), JAK3(1), STAT6(1) 2096972 15 15 15 4 9 1 0 3 2 0 0.211 0.999 1.000 166 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(3), PSMA6(2), PSMB1(1), PSMB2(1), PSMB6(1), PSMB8(2) 1258738 10 8 10 4 5 1 0 2 2 0 0.651 0.999 1.000 167 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(1), IFNB1(2), JAK1(2), PTPRU(2), REG1A(2), STAT2(4), TYK2(1) 1785969 14 12 14 7 3 1 1 4 5 0 0.705 0.999 1.000 168 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(1), CS(1), IDH2(1), OGDH(4) 1351998 7 5 7 4 2 0 1 3 1 0 0.822 0.999 1.000 169 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(1), CDC34(1), CUL1(2), FBXW7(4), RB1(2) 1164333 10 8 10 8 4 0 1 4 0 1 0.961 0.999 1.000 170 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(1), DHRS1(1), DHRS2(3), DHRS3(2), DHRS7(1), HEMK1(2), LCMT1(2), METTL2B(2), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT8(1), WBSCR22(1) 2148701 21 19 21 8 10 4 2 3 2 0 0.217 0.999 1.000 171 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(8), CCNE1(1), CDC34(1), CUL1(2), RB1(2) 1213369 14 11 14 8 7 0 1 5 0 1 0.803 1.000 1.000 172 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 DHCR7(2), FDPS(1), GGCX(1), GGPS1(1), HMGCR(5), IDI1(1), MVD(1), NQO1(1), NSDHL(2), SC4MOL(2), SC5DL(1), SQLE(2), TM7SF2(1) 2746289 21 15 21 6 4 5 3 5 4 0 0.182 1.000 1.000 173 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(2), IFNG(1), IL10(1), IL15(1), IL16(2), IL1A(1), IL3(2), IL5(1) 1410276 12 12 12 7 8 0 1 0 3 0 0.455 1.000 1.000 174 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(9), EIF2AK4(5), EIF2S1(1), GSK3B(1) 1660445 16 12 15 7 6 0 1 6 3 0 0.840 1.000 1.000 175 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(8), AGT(3), AGTR1(2), AGTR2(4), BDKRB2(2), KNG1(2), NOS3(6), REN(3) 1410179 30 23 30 13 23 1 3 2 1 0 0.110 1.000 1.000 176 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(2), FDPS(1), HMGCR(5), IDI1(1), MVD(1), NQO1(1), SC5DL(1), SQLE(2) 1570014 14 11 14 6 2 3 2 5 2 0 0.617 1.000 1.000 177 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(2), BMPR1A(1), BMPR2(2) 897977 5 5 5 3 2 1 0 1 1 0 0.754 1.000 1.000 178 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 HMOX1(1), IL10(1), IL10RA(2), IL10RB(1), IL1A(1), JAK1(2), STAT3(6), STAT5A(1) 1738260 15 12 15 6 5 3 3 3 1 0 0.377 1.000 1.000 179 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(2), ALDOC(2), FBP1(1), FBP2(1), GOT1(3), GOT2(1), GPT(1), MDH2(1), ME1(8), ME2(1), ME3(4), PGK1(3), PKLR(2), PKM2(1), TKT(4) 2576532 35 22 34 10 22 4 2 4 3 0 0.0185 1.000 1.000 180 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(3), ACO2(1), AFMID(1), CS(1), GRHPR(1), HAO1(1), HAO2(1), MDH2(1), MTHFD1(3) 1912547 13 10 12 4 5 0 3 3 2 0 0.294 1.000 1.000 181 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDKN1A(1), CHEK1(1), NEK1(3) 990781 6 5 6 3 3 0 0 2 1 0 0.823 1.000 1.000 182 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(2), C1R(3), C1S(3), C2(3), C3(9), C5(4), C6(21), C7(11), C8A(8), C9(4), MASP1(1), MBL2(5) 3020632 74 41 72 26 55 3 1 10 5 0 0.0358 1.000 1.000 183 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 13 ABL1(6), MDM2(2), PIK3CA(3), PIK3R1(3), POLR1A(2), POLR1B(1), RB1(2), TBX2(1), TWIST1(1) 2620083 21 17 21 9 9 3 1 5 1 2 0.527 1.000 1.000 184 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(3), BCR(2), CRKL(1), FOS(1), GRB2(1), JAK2(2), JUN(1), MAP2K1(3), MAP2K4(1), MAP3K1(1), PIK3CA(3), PIK3R1(3), RAF1(3), SOS1(3), STAT5A(1), STAT5B(1) 3982484 30 22 28 9 15 0 4 5 5 1 0.195 1.000 1.000 185 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(4), ABCC2(2), BCHE(3), CES1(3), CES2(2), CYP3A4(8), CYP3A5(5), UGT1A1(2), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(1), UGT1A8(2), UGT1A9(4) 3270368 44 27 44 13 29 3 2 3 7 0 0.00723 1.000 1.000 186 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(1), CSK(1), GRB2(1), PRKCA(2), PTPRA(2) 1324426 7 6 7 9 3 0 0 2 2 0 0.995 1.000 1.000 187 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(5), ACOX3(3), ELOVL6(1), FADS2(2), FASN(5), HADHA(4), HSD17B12(1), SCD(1) 2024716 22 17 22 7 13 2 0 6 1 0 0.120 1.000 1.000 188 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 20 CCNA1(8), CCND2(1), CCND3(1), CCNE1(1), CDC25A(1), CDK6(1), CDKN1A(1), RB1(2), RBL1(5) 2125272 21 14 21 9 12 1 1 5 1 1 0.459 1.000 1.000 189 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(1), ALAS1(1), ALAS2(3) 1078831 5 5 5 5 3 0 0 1 1 0 0.943 1.000 1.000 190 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(3), ANXA2(1), ANXA6(2), CYP11A1(6), EDN1(3), EDNRA(4), EDNRB(3), HSD11B1(2), PLA2G4A(4), PTGDR(3), PTGER2(2), PTGFR(1), PTGIR(1), PTGIS(2), PTGS1(7), PTGS2(2), S100A6(1), SCGB1A1(1), TBXAS1(3) 2917783 51 36 50 19 32 5 0 7 7 0 0.0291 1.000 1.000 191 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 15 AKT1(3), BCAR1(1), GRB2(1), ITGB1(1), MAPK1(1), PDK2(2), PDPK1(1), PIK3CA(3), PIK3R1(3), PTK2(2), SOS1(3) 2617224 21 19 21 8 10 1 0 6 3 1 0.553 1.000 1.000 192 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(3), B3GALT1(1), B3GALT2(1), FUT1(1), FUT3(1), ST3GAL3(1) 1020444 8 7 8 4 7 1 0 0 0 0 0.402 1.000 1.000 193 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(8), CD44(2), CSF1(4), FCGR3A(1), IL1B(2), IL6R(1), SELL(3), SPN(2), TNFRSF8(7), TNFSF8(1) 1841742 31 22 29 11 22 1 2 3 3 0 0.106 1.000 1.000 194 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(5), CYP11A1(6), CYP11B2(2), CYP17A1(2), HSD11B1(2), HSD3B1(3), HSD3B2(3) 985316 23 20 23 13 14 4 1 3 1 0 0.254 1.000 1.000 195 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(12), CD4(5), CREBBP(4), CSK(1), GNAS(5), HLA-DRA(3), HLA-DRB1(1), LCK(1), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PTPRC(16) 3226876 58 32 57 18 33 5 4 10 6 0 0.0342 1.000 1.000 196 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(12), CD4(5), CREBBP(4), CSK(1), GNAS(5), HLA-DRA(3), HLA-DRB1(1), LCK(1), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PTPRC(16) 3226876 58 32 57 18 33 5 4 10 6 0 0.0342 1.000 1.000 197 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(2), ALDOC(2), FBP1(1), FBP2(1), GOT1(3), GOT2(1), GPT(1), MDH2(1), ME1(8), ME3(4), PGK1(3), PGK2(10), PKLR(2), PKM2(1), TKT(4), TKTL2(8) 2883814 52 30 48 17 34 7 2 6 3 0 0.00970 1.000 1.000 198 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 12 A4GALT(1), FUT1(1), GBGT1(1), HEXB(1), NAGA(1), ST3GAL2(1), ST8SIA1(1) 1342150 7 6 7 7 5 0 0 0 2 0 0.894 1.000 1.000 199 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(2), BHMT(1), CBS(1), CTH(1), DNMT1(6), DNMT3A(1), MARS(2), MARS2(1), MAT1A(2), MAT2B(2), MTR(4) 2514289 23 19 23 8 14 0 2 4 3 0 0.214 1.000 1.000 200 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(1), POLR2A(4), POLR2B(4), POLR2C(1), POLR2D(1), POLR2H(2), POLRMT(1) 1905828 14 13 14 6 8 1 1 3 1 0 0.445 1.000 1.000 201 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(6), CD8A(1), ITGAL(6), ITGB2(2), PTPRC(16) 1518536 31 22 29 13 24 3 1 2 1 0 0.130 1.000 1.000 202 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(2), JAK2(2), JAK3(1), MAPK1(1), STAT3(6), TYK2(1) 1656662 13 11 13 9 5 2 0 3 3 0 0.876 1.000 1.000 203 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH9A1(1) 1134542 7 6 7 6 3 2 0 1 1 0 0.837 1.000 1.000 204 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH9A1(1) 1134542 7 6 7 6 3 2 0 1 1 0 0.837 1.000 1.000 205 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), BIRC3(3), CASP10(1), CASP3(1), CASP8(4), DFFA(1), GZMB(1), SCAP(5), SREBF1(1), SREBF2(1) 2586158 19 17 19 5 13 0 1 4 1 0 0.150 1.000 1.000 206 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(3), F2(2), F2R(1), F5(9), F7(1), FGA(8), FGB(5), FGG(3), PROC(2), PROS1(7), SERPINC1(2), TFPI(1) 2345111 44 28 44 15 29 5 3 6 1 0 0.132 1.000 1.000 207 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 13 A4GALT(1), B3GALNT1(3), FUT1(1), GBGT1(1), HEXB(1), NAGA(1), ST3GAL2(1), ST8SIA1(1) 1431582 10 9 10 7 6 0 2 0 2 0 0.761 1.000 1.000 208 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(2), CBS(1), CTH(1), GGT1(2), MARS(2), MARS2(1), MAT1A(2), MAT2B(2), PAPSS1(1), SCLY(1), SEPHS1(1) 1780424 16 15 16 8 9 1 1 2 3 0 0.517 1.000 1.000 209 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(3), B3GAT2(2), B3GAT3(3), CHPF(2), CHST11(3), CHST12(1), CHST13(1), CHST14(1), CHSY1(2), DSE(5), XYLT1(2), XYLT2(1) 1883890 26 19 26 10 15 5 0 5 1 0 0.115 1.000 1.000 210 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 15 AKT1(3), AKT2(2), AKT3(1), GRB2(1), MAPK1(1), PIK3CA(3), PIK3CD(3), PTK2B(4), RBL2(2), SOS1(3) 2812649 23 17 23 6 11 1 0 9 2 0 0.249 1.000 1.000 211 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT2(3), EXTL1(1), EXTL3(3), GLCE(4), HS3ST1(3), HS3ST2(1), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(1), HS6ST1(2), HS6ST3(4), NDST1(1), NDST2(1), NDST3(7), NDST4(15) 2896676 48 33 48 17 27 5 2 6 8 0 0.0549 1.000 1.000 212 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM2(1), CDKN1A(1), GNAQ(1), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), PLCG1(6), PPP3CA(4), PPP3CB(3), PPP3CC(1), PRKCA(2), SYT1(8) 2953506 39 25 38 10 25 2 2 7 3 0 0.0627 1.000 1.000 213 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1), UGDH(1) 1205706 8 8 8 8 4 1 1 1 1 0 0.898 1.000 1.000 214 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(1), ATM(6), CCNE1(1), CDKN1A(1), MDM2(2), PCNA(2), RB1(2), TIMP3(2) 2367716 17 14 17 8 4 2 1 7 2 1 0.775 1.000 1.000 215 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 17 ARPC2(1), ARPC4(1), NCKAP1(2), NTRK1(5), PIR(1), WASF1(2), WASF2(3), WASF3(4), WASL(1) 2122304 20 18 20 8 11 3 0 2 4 0 0.487 1.000 1.000 216 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(1), HBXIP(1), PTK2B(4), SOS1(3) 1255272 9 9 9 5 6 0 0 2 1 0 0.784 1.000 1.000 217 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 CREB5(2), MAPK1(1), RAF1(3), SNX13(1) 1386994 7 6 7 6 4 0 1 1 1 0 0.897 1.000 1.000 218 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(2), POLE(4), POLG(4), POLL(1), POLQ(7) 2381495 18 18 18 8 11 0 1 3 3 0 0.534 1.000 1.000 219 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 19 B2M(4), ITGB1(1), KLRC1(2), KLRC3(4), KLRC4(2), KLRD1(1), LAT(1), MAP2K1(3), PAK1(2), PIK3CA(3), PIK3R1(3), PTK2B(4), PTPN6(2), SYK(5), VAV1(5) 2583767 42 29 40 15 28 1 0 7 5 1 0.162 1.000 1.000 220 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(3), PSMA6(2), PSMB1(1), PSMB2(1), PSMB6(1), PSMC3(3) 1856987 11 8 11 4 5 2 0 2 2 0 0.611 1.000 1.000 221 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(2), ACO1(3), ACO2(1), ACSS1(1), ACSS2(1), IDH1(3), IDH2(1), MDH2(1) 1908138 13 8 11 3 8 0 0 4 1 0 0.159 1.000 1.000 222 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CDC25A(1), MNAT1(2), SHH(2), XPO1(2) 1245649 7 7 7 5 3 0 1 2 1 0 0.917 1.000 1.000 223 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(1), FOS(1), GNAQ(1), JUN(1), MAPK14(2), PLCG1(6), PRKCA(2), PTK2B(4), SYT1(8) 1970103 26 19 25 10 14 2 2 5 3 0 0.228 1.000 1.000 224 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(1), CLOCK(1), CRY1(1), CRY2(1), CSNK1E(1), PER1(2) 1207014 7 7 7 5 5 1 0 0 1 0 0.821 1.000 1.000 225 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(7), PGAP1(2), PIGA(2), PIGB(1), PIGC(1), PIGG(2), PIGK(1), PIGM(2), PIGN(2), PIGO(6), PIGQ(4), PIGU(1), PIGV(3), PIGW(2), PIGX(1), PIGZ(1) 3408110 38 26 38 11 14 4 6 13 1 0 0.109 1.000 1.000 226 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(6), CDC25A(1), CHEK1(1), MYT1(7) 1972060 15 15 15 9 9 2 0 2 2 0 0.801 1.000 1.000 227 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(4), IARS(2), IARS2(1), ILVBL(1), LARS(3), PDHA1(1), PDHA2(6), VARS(4), VARS2(3) 2691412 25 19 25 8 18 1 1 3 2 0 0.137 1.000 1.000 228 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(6), MAP2(5), PRKACB(3), PRKACG(3), PRKAG1(1), PRKAR2A(1), PRKAR2B(1), PRKCE(2) 2590778 22 16 22 7 11 2 1 3 5 0 0.333 1.000 1.000 229 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), ADSS(2), POLD1(2), POLG(4), PRPS2(1), RRM1(1) 1768088 11 10 11 7 5 0 1 2 3 0 0.880 1.000 1.000 230 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(12), AKT1(3), GNAI1(1), ITGAV(2), ITGB3(3), MAPK1(1), PDGFA(1), PDGFRA(5), PIK3CA(3), PIK3R1(3), PLCB1(16), PRKCA(2), PTK2(2), SMPD1(2), SPHK1(1) 3861921 57 35 57 19 32 3 6 8 7 1 0.0542 1.000 1.000 231 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 APAF1(1), CASP3(1), DAXX(1), FAS(1), FASLG(4), HSPB1(1), HSPB2(1), IL1A(1), MAPKAPK2(2) 1621160 13 11 13 7 6 0 0 5 2 0 0.698 1.000 1.000 232 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(4), AADAC(7), ABAT(1), ACAT2(1), ACSM1(9), AKR1B10(3), ALDH1B1(2), ALDH3A1(1), ALDH5A1(1), ALDH7A1(3), ALDH9A1(1), DDHD1(1), ECHS1(1), EHHADH(2), GAD1(5), GAD2(4), HADHA(4), HMGCS1(1), HMGCS2(5), HSD17B10(2), HSD17B4(4), HSD3B7(2), ILVBL(1), L2HGDH(1), OXCT1(2), OXCT2(1), PDHA1(1), PDHA2(6), PLA1A(3), PRDX6(1), RDH11(1), RDH12(1), RDH13(1) 5787208 83 44 82 23 51 10 5 10 7 0 0.000858 1.000 1.000 233 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BLNK(2), BTK(5), CALM2(1), CD79A(1), ELK1(1), FOS(1), GRB2(1), JUN(1), LYN(2), MAP2K1(3), MAP3K1(1), MAPK14(2), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), PLCG1(6), PPP3CA(4), PPP3CB(3), PPP3CC(1), PRKCA(2), RAF1(3), SOS1(3), SYK(5), SYT1(8), VAV1(5) 5378633 73 41 70 19 46 2 3 15 7 0 0.0129 1.000 1.000 234 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(3), EGFR(4), ERBB3(2), NRG1(4), UBE2D1(1) 1477553 14 13 14 9 8 1 1 3 1 0 0.879 1.000 1.000 235 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(2), CDKN1A(1), EPO(2), HIF1A(3), JAK2(2), NFKB1(1), NFKBIA(1), RELA(2) 1786744 14 11 14 9 3 1 2 6 2 0 0.935 1.000 1.000 236 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(3), APC(6), AXIN1(3), CD14(1), CTNNB1(6), FZD1(2), GJA1(1), GNAI1(1), GSK3B(1), IRAK1(3), LBP(2), LEF1(1), LY96(3), NFKB1(1), PDPK1(1), PIK3CA(3), PIK3R1(3), RELA(2), TIRAP(1), TLR4(6), TOLLIP(1), WNT1(1) 4338374 52 37 52 17 28 3 2 9 9 1 0.120 1.000 1.000 237 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(6), ACACB(3), FASN(5), OLAH(1) 2239690 15 14 15 5 9 1 0 4 1 0 0.244 1.000 1.000 238 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 20 AKT1(3), EIF4A1(1), EIF4A2(2), EIF4G1(2), EIF4G2(1), EIF4G3(4), MKNK1(2), PDK2(2), PDPK1(1), PIK3CA(3), PIK3R1(3), TSC1(1), TSC2(3) 3824275 28 24 28 9 14 2 1 7 3 1 0.316 1.000 1.000 239 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), HEMK1(2), LCMT1(2), METTL2B(2), METTL6(1), PCYT1A(1), PCYT1B(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT8(1), WBSCR22(1) 2002224 16 14 16 8 6 2 2 4 2 0 0.579 1.000 1.000 240 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(3), BAIAP2(3), CASP3(1), CASP8(4), INSR(6), ITCH(1), MAGI1(11), MAGI2(4), RERE(8), WWP1(1), WWP2(1) 3436113 43 31 43 14 27 2 1 9 4 0 0.192 1.000 1.000 241 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(12), AKT1(3), CSF2RB(6), IGF1(5), IGF1R(4), IL3(2), IL3RA(3), PIK3CA(3), PIK3R1(3), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1) 3120663 51 35 51 20 31 4 2 6 7 1 0.0916 1.000 1.000 242 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(2), ALOX15B(2), DPEP1(1), GGT1(2), LTA4H(2), PLA2G6(2), PTGIS(2), PTGS1(7), PTGS2(2), TBXAS1(3) 2119116 25 16 25 11 16 2 1 3 3 0 0.145 1.000 1.000 243 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(2), UBE2D1(1), UBE2I(1), UBE2J1(2), UBE2L6(1), UBE2S(1) 1510762 9 7 9 6 4 1 1 2 1 0 0.885 1.000 1.000 244 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(4), CARS2(1), CDO1(2), CTH(1), GOT1(3), GOT2(1), LDHA(1), LDHAL6A(4), LDHAL6B(1), LDHB(2), LDHC(2), SULT1B1(4), SULT1C4(3), SULT4A1(1) 1790407 30 20 29 11 19 1 3 5 2 0 0.207 1.000 1.000 245 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(3), GNA12(1), GNAQ(1), MYL2(1), MYLK(9), PLCB1(16), PPP1R12B(4), PRKCA(2), ROCK1(2) 2962098 39 25 39 12 25 0 2 7 5 0 0.113 1.000 1.000 246 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(4), G6PD(1), GCLC(1), GGT1(2), GPX1(1), GPX5(2), GSS(2), GSTA1(2), GSTM3(1), GSTM5(1), GSTP1(1), IDH1(3), IDH2(1), MGST1(1), MGST2(1), MGST3(1), PGD(2) 2566707 27 20 26 10 17 2 2 5 1 0 0.113 1.000 1.000 247 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH6(3), ADH7(5), AKR1D1(7), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH9A1(1), BAAT(2), CEL(5), CYP27A1(2), CYP7A1(1), SOAT2(1), SRD5A1(1), SRD5A2(3) 3333566 56 31 54 22 39 7 2 6 2 0 0.0809 1.000 1.000 248 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(3), AKT2(2), AKT3(1), GRB2(1), GSK3B(1), IL4R(6), IRS1(1), JAK1(2), JAK3(1), MAP4K1(3), MAPK1(1), PIK3CA(3), PIK3CD(3), PIK3R1(3), PPP1R13B(3), RAF1(3), SOS1(3), SOS2(4), STAT6(1) 5189103 45 28 45 10 23 2 3 11 5 1 0.0245 1.000 1.000 249 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR2(2), CCR3(5), CCR4(4), CCR7(1), CD4(5), CXCR3(1), IFNG(1), IFNGR1(1), IFNGR2(2), IL12RB1(3), IL18R1(4), IL4R(6), IL5(1), TGFB3(2) 2842536 38 26 38 15 23 1 0 7 7 0 0.0985 1.000 1.000 250 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(2), CHUK(1), IFNG(1), IKBKB(3), JUN(1), MAP3K1(1), MAP3K5(5), MAP4K5(2), MAPK14(2), NFKB1(1), NFKBIA(1), RELA(2) 2740297 22 19 22 9 8 3 1 6 4 0 0.472 1.000 1.000 251 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ESR1(2), GREB1(4), HSPB1(1), HSPB2(1), MTA1(1), PDZK1(1) 1517285 10 9 10 6 6 0 1 3 0 0 0.721 1.000 1.000 252 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(14), COL4A2(8), COL4A3(13), COL4A4(22), COL4A5(20), COL4A6(6), P4HB(1), SLC23A2(2), SLC2A1(3), SLC2A3(3) 3556299 92 50 90 20 72 4 3 6 7 0 0.0785 1.000 1.000 253 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(4) 1728275 14 13 14 9 6 4 0 3 1 0 0.723 1.000 1.000 254 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(5), CFL1(1), GNAQ(1), GNAS(5), MAP2K1(3), MAPK1(1), MYL2(1), NOX1(3), PIK3C2G(10), PLCB1(16), PPP1R12B(4), PRKCA(2), PTK2(2), RAF1(3), ROCK2(6) 3574910 64 41 62 21 41 1 4 13 5 0 0.0941 1.000 1.000 255 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(3), ABAT(1), ACY3(1), ADSL(1), ADSS(2), ADSSL1(5), AGXT(7), AGXT2(5), ASL(2), ASNS(3), ASS1(2), CAD(4), DARS2(2), DDO(3), DLAT(1), GAD1(5), GAD2(4), GOT1(3), GOT2(1), GPT(1), NARS(1), NARS2(1), PC(7), PDHA1(1), PDHA2(6) 5398849 72 46 71 23 45 8 4 11 4 0 0.00922 1.000 1.000 256 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 ELK1(1), FOS(1), GRB2(1), INSR(6), IRS1(1), JUN(1), MAP2K1(3), PIK3CA(3), PIK3R1(3), PTPN11(2), RAF1(3), RASA1(1), SLC2A4(3), SOS1(3) 3653547 32 22 30 10 12 1 2 12 4 1 0.360 1.000 1.000 257 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(2), F2R(1), F2RL3(2), GNAI1(1), ITGA1(3), ITGB1(1), MAP2K1(3), MAPK1(1), PLA2G4A(4), PLCB1(16), PRKCA(2), PTGS1(7), PTK2(2), RAF1(3), SYK(5), TBXAS1(3) 3467261 56 33 54 20 36 3 3 7 7 0 0.0751 1.000 1.000 258 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 AKT1(3), AP2M1(2), BTK(5), EEA1(1), GSK3B(1), LYN(2), PDPK1(1), PFKL(2), PFKM(1), PLCG1(6), PRKCE(2), RAB5A(1) 3449919 27 19 27 9 13 3 2 6 3 0 0.132 1.000 1.000 259 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(6), FOS(1), GRB2(1), IL3(2), IL3RA(3), JAK2(2), MAP2K1(3), PTPN6(2), RAF1(3), SOS1(3), STAT5A(1), STAT5B(1) 2498003 28 22 26 12 18 1 2 3 4 0 0.384 1.000 1.000 260 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(3), CHRNG(1), MUSK(11), PIK3CA(3), PIK3R1(3), PTK2(2), PTK2B(4), RAPSN(1), TERT(1) 2314275 29 23 29 12 16 2 0 8 2 1 0.284 1.000 1.000 261 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(3), PSMA6(2), PSMB1(1), PSMB2(1), PSMB6(1), PSMC2(2), PSMC3(3), PSMD1(2) 2301872 15 11 15 8 8 2 0 3 2 0 0.830 1.000 1.000 262 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(1), AKT1(3), AKT2(2), AKT3(1), BTK(5), DAPP1(1), GRB2(1), GSK3B(1), IARS(2), IGFBP1(1), INPP5D(6), PIK3CA(3), PPP1R13B(3), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), SOS1(3), SOS2(4), TEC(4), YWHAB(1), YWHAQ(1) 4933750 50 33 49 13 30 1 4 11 4 0 0.0534 1.000 1.000 263 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(1), BIK(1), BIRC3(3), CASP3(1), CASP8(4), DFFA(1) 1924487 11 11 11 5 6 0 1 4 0 0 0.687 1.000 1.000 264 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(3), CARS(4), EPRS(5), FARS2(1), GARS(2), HARS(2), IARS(2), LARS(3), MARS(2), MARS2(1), NARS(1), QARS(1), RARS(1), SARS(6), TARS(1), WARS(1), WARS2(2) 4599355 38 21 38 9 20 5 3 8 2 0 0.0392 1.000 1.000 265 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(2), BHMT(1), CBS(1), CTH(1), DNMT1(6), DNMT3A(1), MARS(2), MARS2(1), MAT1A(2), MAT2B(2), MTR(4), TAT(4) 2987138 27 21 27 10 16 1 2 5 3 0 0.269 1.000 1.000 266 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(5), CALM2(1), ELK1(1), FCER1A(4), FOS(1), GRB2(1), JUN(1), LYN(2), MAP2K1(3), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAPK1(1), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), PAK2(5), PIK3CA(3), PIK3R1(3), PLA2G4A(4), PLCG1(6), PPP3CA(4), PPP3CB(3), PPP3CC(1), RAF1(3), SOS1(3), SYK(5), SYT1(8), VAV1(5) 6110357 88 44 85 24 52 3 6 20 6 1 0.0150 1.000 1.000 267 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(4), CD2(6), CD33(5), IFNA1(1), IFNB1(2), IFNG(1), IL10(1), IL3(2), IL5(1), ITGAX(6), TLR2(2), TLR4(6), TLR7(8), TLR9(3) 2646055 48 34 47 24 31 4 3 5 5 0 0.112 1.000 1.000 268 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH5(1), ADH6(3), ADH7(5), AKR1B10(3), AKR1D1(7), ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1), BAAT(2), CEL(5), CYP27A1(2), CYP7A1(1), HSD3B7(2), RDH11(1), RDH12(1), RDH13(1), SLC27A5(2), SOAT1(3), SOAT2(1), SRD5A1(1), SRD5A2(3) 4532861 70 36 67 28 46 10 4 7 3 0 0.0577 1.000 1.000 269 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), BIRC3(3), CASP10(1), CASP3(1), CASP8(4), DFFA(1), GZMB(1), LMNA(4), LMNB1(1), LMNB2(2) 2795111 19 15 19 8 8 3 1 7 0 0 0.560 1.000 1.000 270 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(4), EP300(1), ESR1(2), MAPK1(1), PELP1(1) 2089337 9 7 9 9 3 0 0 5 1 0 0.983 1.000 1.000 271 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(1), IFNA1(1), IFNB1(2), IKBKB(3), IL1A(1), IL1B(2), IL1R1(2), IL1RAP(1), IL1RN(1), IRAK1(3), IRAK2(2), IRAK3(2), JUN(1), MAP2K3(4), MAP2K6(1), MAP3K1(1), MAPK14(2), NFKB1(1), NFKBIA(1), RELA(2), TGFB3(2), TOLLIP(1), TRAF6(1) 4201427 38 32 36 13 20 6 1 7 4 0 0.132 1.000 1.000 272 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 FOS(1), GRB2(1), JAK2(2), JUN(1), MAP2K1(3), MPL(2), PIK3CA(3), PIK3R1(3), PLCG1(6), PRKCA(2), RAF1(3), RASA1(1), SOS1(3), STAT3(6), STAT5A(1), STAT5B(1), THPO(2) 4256918 41 27 39 13 20 3 4 8 5 1 0.239 1.000 1.000 273 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(1), CS(1), DLAT(1), IDH2(1), IDH3G(1), MDH2(1), OGDH(4), PC(7), PDHA1(1), PDHA2(6), PDK2(2), PDK3(2), PDK4(1), PDP2(2), SDHB(1), SUCLG2(1) 4054263 33 22 33 11 16 2 3 6 6 0 0.176 1.000 1.000 274 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 41 CALM2(1), ELK1(1), FOS(1), FYN(1), GRB2(1), JUN(1), LAT(1), LCK(1), MAP2K1(3), MAP2K4(1), MAP3K1(1), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), NFKB1(1), NFKBIA(1), PIK3CA(3), PIK3R1(3), PLCG1(6), PPP3CA(4), PPP3CB(3), PPP3CC(1), PRKCA(2), PTPN7(1), RAF1(3), RASA1(1), RELA(2), SOS1(3), SYT1(8), VAV1(5) 6736262 72 41 69 20 41 5 5 15 5 1 0.0300 1.000 1.000 275 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 ELK1(1), EPO(2), FOS(1), GRB2(1), JAK2(2), JUN(1), MAP2K1(3), PLCG1(6), PTPN6(2), RAF1(3), SOS1(3), STAT5A(1), STAT5B(1) 3030249 27 21 25 11 16 1 3 4 3 0 0.392 1.000 1.000 276 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(3), AKT2(2), AKT3(1), BCR(2), BLNK(2), BTK(5), CD19(4), CSK(1), DAG1(1), EPHB2(8), GRB2(1), ITPKB(1), LYN(2), MAP2K1(3), MAP2K2(2), MAPK1(1), NFAT5(2), NFKB1(1), NFKB2(2), NFKBIA(1), NFKBIL1(2), NFKBIL2(2), PI3(1), PIK3CA(3), PIK3CD(3), PIK3R1(3), PLCG2(6), PPP1R13B(3), RAF1(3), SERPINA4(7), SOS1(3), SOS2(4), SYK(5), VAV1(5) 7509122 95 50 93 29 55 3 8 19 9 1 0.00858 1.000 1.000 277 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(2), AGT(3), AGTR2(4), EDN1(3), EDNRA(4), EDNRB(3), EGF(3), EGFR(4), FOS(1), JUN(1), NFKB1(1), PLCG1(6), PRKCA(2), RELA(2) 2928116 39 29 38 17 21 5 2 10 1 0 0.314 1.000 1.000 278 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(4), ABAT(1), ACAT2(1), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH5A1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), GAD1(5), GAD2(4), HADHA(4), L2HGDH(1), OXCT1(2), PDHA1(1), PDHA2(6), SDHB(1) 3694899 41 29 41 16 22 7 0 6 6 0 0.132 1.000 1.000 279 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM2(1), CHUK(1), EGR2(2), GNAQ(1), MAP3K1(1), NFATC1(5), NFATC2(2), NFKB1(1), NFKBIA(1), PLCG1(6), PPP3CA(4), PPP3CB(3), PPP3CC(1), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RELA(2), SYT1(8), VIP(1) 3978681 50 28 49 17 29 4 4 9 4 0 0.127 1.000 1.000 280 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), CHUK(1), ELK1(1), FOS(1), IKBKB(3), IRAK1(3), JUN(1), LY96(3), MAP2K3(4), MAP2K4(1), MAP2K6(1), MAP3K1(1), MAPK14(2), NFKB1(1), NFKBIA(1), PPARA(3), RELA(2), TIRAP(1), TLR10(2), TLR2(2), TLR3(4), TLR4(6), TLR6(4), TLR7(8), TLR9(3), TOLLIP(1), TRAF6(1) 5171019 62 39 62 23 33 9 4 13 3 0 0.117 1.000 1.000 281 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH5A1(1), CAD(4), CPS1(5), EPRS(5), GAD1(5), GAD2(4), GCLC(1), GFPT1(2), GLS(1), GLUL(2), GOT1(3), GOT2(1), GPT(1), GSS(2), QARS(1) 4738718 39 29 38 15 17 5 5 8 4 0 0.248 1.000 1.000 282 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(2), GHR(8), GRB2(1), INSR(6), IRS1(1), JAK2(2), MAP2K1(3), MAPK1(1), PIK3CA(3), PIK3R1(3), PLCG1(6), PRKCA(2), PTPN6(2), RAF1(3), RPS6KA1(1), SLC2A4(3), SOS1(3), STAT5A(1), STAT5B(1) 4722287 52 34 49 18 27 2 4 11 7 1 0.155 1.000 1.000 283 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(4), APOA4(1), CETP(4), CYP7A1(1), HMGCR(5), LDLR(3), LIPC(3), LPL(1), LRP1(7), SOAT1(3) 3941358 32 21 32 12 15 4 3 5 5 0 0.241 1.000 1.000 284 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 ELK1(1), FOS(1), GRB2(1), IL6R(1), IL6ST(5), JAK1(2), JAK2(2), JAK3(1), JUN(1), MAP2K1(3), PTPN11(2), RAF1(3), SOS1(3), STAT3(6) 3385692 32 17 30 12 14 2 1 11 4 0 0.522 1.000 1.000 285 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(3), CABIN1(3), CALM2(1), CAMK1(2), CAMK1G(1), IGF1(5), IGF1R(4), INSR(6), MAP2K6(1), MAPK14(2), MAPK7(1), MEF2A(1), MEF2D(1), NFATC1(5), NFATC2(2), PIK3CA(3), PIK3R1(3), PPP3CA(4), PPP3CB(3), PPP3CC(1), SYT1(8) 4954177 60 35 59 21 36 3 2 14 4 1 0.0807 1.000 1.000 286 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(3), APAF1(1), ATM(6), CASP3(1), EIF2S1(1), PRKCA(2), PTK2(2), PXN(1), TLN1(2) 3777305 19 18 19 8 9 2 0 5 3 0 0.535 1.000 1.000 287 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(3), AKT2(2), AKT3(1), CISH(2), GRB2(1), IARS(2), IL13RA1(1), IL4R(6), INPP5D(6), JAK1(2), JAK2(2), JAK3(1), NR0B2(1), PI3(1), PIK3CA(3), PPP1R13B(3), SERPINA4(7), SOS1(3), SOS2(4), STAT6(1), TYK2(1) 5238902 53 35 53 17 36 0 2 9 6 0 0.105 1.000 1.000 288 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(4), EP300(1), LPL(1), NCOA1(3), NCOA2(2), PPARG(4) 2652551 15 15 15 7 9 0 0 5 1 0 0.721 1.000 1.000 289 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(12), CALM2(1), ELK1(1), FOS(1), GNAI1(1), GNAQ(1), GNAS(5), JUN(1), MAP2K1(3), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), PLCG1(6), PPP3CA(4), PPP3CB(3), PPP3CC(1), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCA(2), RAF1(3), RPS6KA3(1), SYT1(8) 4940183 76 38 73 26 45 4 6 12 9 0 0.0650 1.000 1.000 290 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2E1(1), GTF2F1(3), NCOA1(3), NCOA2(2), NCOA3(4), NCOR2(8), POLR2A(4), RARA(2), TBP(2) 3542462 30 22 30 11 24 0 3 3 0 0 0.204 1.000 1.000 291 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(2), AP2M1(2), BIN1(1), CALM2(1), DNM1(1), EPN1(1), EPS15(3), PPP3CA(4), PPP3CB(3), PPP3CC(1), SYNJ1(7), SYNJ2(2), SYT1(8) 3042177 36 25 35 14 21 4 1 9 1 0 0.311 1.000 1.000 292 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 CDK5(1), CFL1(1), CHN1(1), MAP3K1(1), MYL2(1), MYLK(9), NCF2(2), PAK1(2), PDGFRA(5), PIK3CA(3), PIK3R1(3), PLD1(5), PPP1R12B(4), TRIO(6), VAV1(5), WASF1(2) 4940303 51 33 51 18 28 4 4 10 4 1 0.150 1.000 1.000 293 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(2), ALDOC(2), DLAT(1), ENO1(1), ENO2(1), ENO3(1), FBP1(1), FBP2(1), GCK(5), GOT1(3), GOT2(1), GPI(1), HK1(2), HK2(4), HK3(3), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(2), MDH2(1), PC(7), PCK1(3), PDHA1(1), PDHA2(6), PFKL(2), PFKM(1), PGAM2(1), PGK1(3), PGK2(10), PKLR(2), PKM2(1), TNFAIP1(1) 6044285 74 46 73 27 49 5 4 11 5 0 0.00890 1.000 1.000 294 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ARG1(1), ASL(2), ASS1(2), CKM(1), CKMT2(2), CPS1(5), DAO(3), EPRS(5), GAMT(1), GATM(2), GOT1(3), GOT2(1), NOS1(17), NOS3(6), OTC(1), P4HA1(3), P4HA2(2), P4HA3(5), PRODH(1), RARS(1) 5107777 64 37 63 27 43 5 6 5 5 0 0.0818 1.000 1.000 295 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(4), CSF1R(4), DDX20(4), ETS1(1), ETS2(2), FOS(1), HDAC2(1), JUN(1), NCOR2(8), RBL1(5), RBL2(2), SIN3A(1) 3693313 34 25 34 15 22 0 1 7 4 0 0.367 1.000 1.000 296 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM2(1), CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), ESRRA(1), MEF2A(1), MEF2D(1), PPARA(3), PPP3CA(4), PPP3CB(3), PPP3CC(1), SLC2A4(3), SYT1(8) 2853761 38 27 37 17 23 4 2 5 4 0 0.278 1.000 1.000 297 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ADC(1), ALDH5A1(1), CAD(4), CPS1(5), EPRS(5), GAD1(5), GAD2(4), GCLC(1), GFPT1(2), GFPT2(3), GLS(1), GLUL(2), GOT1(3), GOT2(1), GPT(1), GSS(2), QARS(1) 5632958 43 30 42 17 20 6 5 8 4 0 0.210 1.000 1.000 298 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 27 BCAR1(1), CALM2(1), CRKL(1), GNAQ(1), GRB2(1), JUN(1), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(1), MAP3K1(1), MAPK1(1), MAPK14(2), PAK1(2), PLCG1(6), PRKCA(2), PTK2B(4), RAF1(3), SOS1(3), SYT1(8) 3993602 48 32 45 19 25 4 4 9 6 0 0.325 1.000 1.000 299 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(2), ALDOC(2), DERA(2), FBP1(1), FBP2(1), G6PD(1), GPI(1), H6PD(2), PFKL(2), PFKM(1), PGD(2), PGLS(1), PGM1(3), PRPS1(2), PRPS1L1(2), PRPS2(1), RBKS(1), TKT(4), TKTL2(8) 3444568 39 26 37 19 21 7 3 3 5 0 0.216 1.000 1.000 300 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 ELK1(1), FOS(1), GRB2(1), IL2RA(1), IL2RB(2), JAK1(2), JAK3(1), JUN(1), LCK(1), MAP2K1(3), RAF1(3), SOS1(3), STAT5A(1), STAT5B(1), SYK(5) 3268505 27 23 25 12 18 1 2 4 2 0 0.389 1.000 1.000 301 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(4), BCAR1(1), CSK(1), CTNNA2(3), CTNNB1(6), PTK2(2), PXN(1), VCL(2) 2685245 21 18 21 10 12 2 1 5 1 0 0.425 1.000 1.000 302 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 ELK1(1), FOS(1), GRB2(1), JAK1(2), JUN(1), MAP2K1(3), MAP2K4(1), MAP3K1(1), PDGFA(1), PDGFRA(5), PIK3CA(3), PIK3R1(3), PLCG1(6), PRKCA(2), RAF1(3), RASA1(1), SOS1(3), STAT3(6), STAT5A(1) 4969423 45 30 43 15 22 4 5 9 4 1 0.228 1.000 1.000 303 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10(1), ALG10B(3), ALG12(1), ALG13(3), ALG14(1), ALG2(2), ALG3(1), ALG5(1), ALG6(1), ALG8(4), ALG9(4), B4GALT1(1), B4GALT2(1), B4GALT3(1), DDOST(1), DPAGT1(1), FUT8(2), GANAB(2), MAN1A1(5), MAN1A2(1), MAN2A1(4), MGAT1(1), MGAT3(2), MGAT4A(3), MGAT4B(1), MGAT5B(5), RFT1(1), ST6GAL1(1), STT3B(2) 6034337 58 37 58 21 34 7 3 6 8 0 0.0714 1.000 1.000 304 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(1), BIRC3(3), CASP3(1), CASP8(4), FAS(1), FASLG(4), GZMB(1), JUN(1), MAP2K4(1), MAP3K1(1), MAPK10(2), MCL1(2), MDM2(2), NFKB1(1), NFKBIA(1), PARP1(3), RELA(2), TNFSF10(3), TRAF1(1) 5184269 35 27 35 13 14 5 6 8 2 0 0.281 1.000 1.000 305 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(3), CALM2(1), CAPN2(2), EP300(1), HDAC1(1), HDAC2(1), MEF2D(1), NFATC1(5), NFATC2(2), PPP3CA(4), PPP3CB(3), PPP3CC(1), PRKCA(2), SYT1(8) 3492531 35 22 34 13 23 1 3 5 3 0 0.294 1.000 1.000 306 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 59 A4GALT(1), ABO(3), B3GALNT1(3), B3GALT1(1), B3GALT2(1), B3GALT4(2), B3GNT1(2), B3GNT2(1), B3GNT3(3), B3GNT4(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), B4GALT4(1), FUT1(1), FUT3(1), FUT5(3), FUT6(3), GBGT1(1), PIGA(2), PIGB(1), PIGC(1), PIGG(2), PIGK(1), PIGM(2), PIGN(2), PIGO(6), PIGQ(4), PIGU(1), PIGV(3), PIGX(1), PIGZ(1), ST3GAL2(1), ST3GAL3(1), ST6GALNAC5(3), ST8SIA1(1) 6781353 64 37 64 21 36 5 6 11 6 0 0.0224 1.000 1.000 307 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 73 AKT1(3), AKT2(2), AKT3(1), BTK(5), FCER1A(4), FYN(1), GAB2(2), GRB2(1), IL3(2), IL5(1), INPP5D(6), LAT(1), LCP2(4), LYN(2), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(1), MAP2K6(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK9(1), MS4A2(2), NRAS(1), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PLA2G2D(2), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), PLCG1(6), PLCG2(6), PRKCA(2), PRKCD(2), PRKCE(2), RAF1(3), SOS1(3), SOS2(4), SYK(5), VAV1(5), VAV3(1) 10195783 145 57 143 37 76 10 7 35 16 1 0.000126 1.000 1.000 308 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 29 AKR1D1(7), ARSB(1), ARSE(1), CYP11B1(4), CYP11B2(2), HSD11B1(2), HSD17B2(3), HSD3B1(3), HSD3B2(3), SRD5A1(1), SRD5A2(3), STS(1), SULT1E1(2), SULT2A1(1), UGT1A1(2), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(1), UGT1A8(2), UGT1A9(4), UGT2B4(7) 3591942 58 37 57 27 39 7 3 4 5 0 0.159 1.000 1.000 309 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(5), ESR1(2), ESR2(3), ESRRA(1), HNF4A(3), NPM1(2), NR0B1(1), NR1D2(2), NR1H2(2), NR1H3(2), NR1I3(2), NR2F1(1), NR2F6(1), NR4A1(2), NR4A2(1), NR5A1(1), NR5A2(3), PGR(4), PPARA(3), PPARG(4), RARA(2), RARB(1), ROR1(2), RORA(2), RORC(2), RXRG(2), THRA(1), THRB(5), VDR(1) 5925608 63 36 62 25 42 5 2 7 7 0 0.0528 1.000 1.000 310 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 189 ACTB(3), ACTG1(1), ACTN1(1), ACTN2(4), ACTN4(1), AKT1(3), AKT2(2), AKT3(1), ARHGAP5(3), BCAR1(1), BIRC3(3), CAPN2(2), CCND2(1), CCND3(1), CDC42(2), COL11A1(17), COL11A2(8), COL1A1(15), COL1A2(13), COL2A1(9), COL3A1(20), COL4A1(14), COL4A2(8), COL4A4(22), COL4A6(6), COL5A1(10), COL5A2(12), COL5A3(16), COL6A1(1), COL6A2(6), COL6A3(16), COL6A6(13), COMP(4), CRKL(1), CTNNB1(6), DOCK1(2), EGF(3), EGFR(4), ELK1(1), ERBB2(1), FARP2(4), FIGF(2), FLNA(6), FLNB(8), FLNC(15), FLT1(8), FN1(9), FYN(1), GRB2(1), GRLF1(2), GSK3B(1), HGF(7), IBSP(4), IGF1(5), IGF1R(4), ITGA1(3), ITGA10(1), ITGA11(6), ITGA2(2), ITGA2B(5), ITGA3(2), ITGA4(10), ITGA5(4), ITGA6(3), ITGA7(5), ITGA8(7), ITGA9(4), ITGAV(2), ITGB1(1), ITGB3(3), ITGB4(5), ITGB6(1), ITGB7(1), ITGB8(4), JUN(1), KDR(8), LAMA1(7), LAMA2(12), LAMA3(16), LAMA4(3), LAMA5(5), LAMB1(1), LAMB2(1), LAMB3(2), LAMB4(9), LAMC1(6), LAMC2(4), LAMC3(2), MAP2K1(3), MAPK1(1), MAPK10(2), MAPK9(1), MET(8), MYL2(1), MYL5(1), MYL7(1), MYL9(1), MYLK(9), MYLK2(2), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PAK7(10), PARVB(1), PARVG(1), PDGFA(1), PDGFC(3), PDGFD(1), PDGFRA(5), PDGFRB(3), PDPK1(1), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PIP5K1C(2), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PRKCA(2), PRKCG(5), PTK2(2), PXN(1), RAF1(3), RAPGEF1(3), RELN(16), RHOA(1), ROCK1(2), ROCK2(6), SHC2(2), SHC3(2), SOS1(3), SOS2(4), SPP1(1), THBS1(8), THBS2(5), THBS3(4), THBS4(2), TLN1(2), TLN2(11), TNC(7), TNN(12), TNR(15), TNXB(42), VASP(1), VAV1(5), VAV3(1), VCL(2), VEGFA(2), VEGFB(1), VEGFC(6), VTN(2), VWF(11), ZYX(2) 52396345 784 92 778 323 510 60 32 114 67 1 0.00213 1.000 1.000 311 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 135 ACTB(3), ACTG1(1), COL11A1(17), COL11A2(8), COL17A1(8), COL1A1(15), COL1A2(13), COL2A1(9), COL3A1(20), COL4A1(14), COL4A2(8), COL4A4(22), COL4A6(6), COL5A1(10), COL5A2(12), COL5A3(16), COL6A1(1), COL6A2(6), COL6A3(16), COL6A6(13), COMP(4), DES(1), DSC1(9), DSC2(6), DSC3(7), DSG1(12), DSG2(8), DSG4(13), FN1(9), GJA1(1), GJA10(3), GJA5(2), GJA8(4), GJA9(1), GJB3(1), GJB4(4), GJB6(1), GJB7(1), GJD2(1), IBSP(4), INA(2), ITGA6(3), ITGB4(5), KRT1(5), KRT10(7), KRT12(5), KRT13(3), KRT14(1), KRT15(2), KRT16(1), KRT17(1), KRT2(4), KRT20(5), KRT23(3), KRT24(1), KRT25(4), KRT27(1), KRT28(4), KRT3(2), KRT31(3), KRT32(3), KRT33B(1), KRT34(7), KRT36(4), KRT37(2), KRT38(2), KRT39(3), KRT4(5), KRT40(2), KRT5(6), KRT6A(4), KRT6B(2), KRT6C(7), KRT7(1), KRT71(4), KRT72(4), KRT73(2), KRT74(3), KRT75(6), KRT76(3), KRT77(2), KRT78(2), KRT79(4), KRT8(1), KRT82(3), KRT83(1), KRT84(3), KRT85(2), KRT86(1), KRT9(6), LAMA1(7), LAMA2(12), LAMA3(16), LAMA4(3), LAMA5(5), LAMB1(1), LAMB2(1), LAMB3(2), LAMB4(9), LAMC1(6), LAMC2(4), LAMC3(2), LMNA(4), LMNB1(1), LMNB2(2), NES(6), RELN(16), SPP1(1), THBS1(8), THBS2(5), THBS3(4), THBS4(2), TNC(7), TNN(12), TNR(15), TNXB(42), VIM(1), VTN(2), VWF(11) 35217132 675 91 667 284 470 58 21 71 55 0 0.00178 1.000 1.000 312 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 234 ADCYAP1R1(5), ADORA1(1), ADORA2A(1), ADORA3(3), ADRA1A(3), ADRA2B(3), ADRA2C(1), AGTR1(2), AGTR2(4), AVPR1B(1), AVPR2(1), BDKRB1(2), BDKRB2(2), BRS3(1), C3AR1(1), C5AR1(3), CALCR(3), CALCRL(5), CCKBR(2), CHRM2(3), CHRM3(8), CHRM4(1), CHRM5(1), CNR1(1), CNR2(1), CRHR1(1), CRHR2(1), CTSG(1), CYSLTR1(2), DRD1(1), DRD2(7), DRD5(8), EDNRA(4), EDNRB(3), F2(2), F2R(1), F2RL1(3), F2RL2(2), F2RL3(2), FPR1(3), FSHB(2), FSHR(5), GABBR1(1), GABBR2(4), GABRA1(5), GABRA2(8), GABRA3(7), GABRA4(4), GABRA6(8), GABRB1(6), GABRB2(8), GABRB3(3), GABRE(9), GABRG1(7), GABRG2(7), GABRG3(3), GABRQ(2), GABRR1(2), GALR1(2), GALR3(1), GH1(2), GH2(2), GHR(8), GHRHR(1), GHSR(3), GLP1R(4), GLP2R(4), GLRA1(4), GLRA2(4), GLRA3(1), GLRB(2), GNRHR(1), GPR156(1), GPR50(4), GPR63(1), GPR83(2), GRIA1(10), GRIA2(14), GRIA3(6), GRIA4(8), GRID1(6), GRID2(14), GRIK1(9), GRIK2(7), GRIK3(12), GRIK4(4), GRIK5(3), GRIN2A(27), GRIN2B(16), GRIN2C(2), GRIN2D(1), GRIN3A(7), GRIN3B(1), GRM1(4), GRM2(1), GRM3(11), GRM4(3), GRM5(3), GRM6(4), GRM7(6), GRM8(17), GRPR(2), GZMA(4), HCRTR1(2), HCRTR2(6), HRH1(3), HRH4(3), HTR1A(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2C(3), HTR4(3), HTR5A(3), HTR7(3), LEP(1), LEPR(4), LHCGR(7), LTB4R2(1), MAS1(1), MC2R(1), MC3R(1), MC5R(3), MCHR2(6), MTNR1A(1), MTNR1B(2), NMBR(4), NMUR1(4), NMUR2(3), NPBWR1(1), NPBWR2(1), NPFFR1(1), NPFFR2(4), NPY1R(9), NPY2R(3), NPY5R(8), NTSR1(2), NTSR2(1), OPRD1(2), OPRK1(5), OPRL1(3), OPRM1(1), OXTR(1), P2RX2(2), P2RX3(1), P2RX4(1), P2RX5(1), P2RX7(1), P2RY1(1), P2RY10(1), P2RY13(2), P2RY14(1), P2RY6(1), P2RY8(1), PARD3(4), PPYR1(2), PRLHR(1), PRLR(9), PRSS3(1), PTAFR(1), PTGDR(3), PTGER2(2), PTGER3(2), PTGFR(1), PTGIR(1), PTH2R(5), RXFP1(3), RXFP2(11), SCTR(2), SSTR1(3), SSTR2(1), SSTR3(5), SSTR5(2), TAAR2(2), TAAR6(1), TAAR8(2), TACR1(3), TACR2(1), TACR3(8), THRA(1), THRB(5), TSHB(1), TSHR(5), VIPR1(1) 31107192 653 91 635 354 449 51 23 77 52 1 8.28e-06 1.000 1.000 313 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(4), CD44(2), CD47(1), COL11A1(17), COL11A2(8), COL1A1(15), COL1A2(13), COL2A1(9), COL3A1(20), COL4A1(14), COL4A2(8), COL4A4(22), COL4A6(6), COL5A1(10), COL5A2(12), COL5A3(16), COL6A1(1), COL6A2(6), COL6A3(16), COL6A6(13), DAG1(1), FN1(9), FNDC1(6), FNDC3A(2), FNDC5(1), GP9(1), HSPG2(9), IBSP(4), ITGA1(3), ITGA10(1), ITGA11(6), ITGA2(2), ITGA2B(5), ITGA3(2), ITGA4(10), ITGA5(4), ITGA6(3), ITGA7(5), ITGA8(7), ITGA9(4), ITGAV(2), ITGB1(1), ITGB3(3), ITGB4(5), ITGB6(1), ITGB7(1), ITGB8(4), LAMA1(7), LAMA2(12), LAMA3(16), LAMA4(3), LAMA5(5), LAMB1(1), LAMB2(1), LAMB3(2), LAMB4(9), LAMC1(6), LAMC2(4), LAMC3(2), RELN(16), SDC1(1), SDC2(1), SDC3(4), SDC4(1), SPP1(1), SV2A(1), SV2B(8), SV2C(3), THBS1(8), THBS2(5), THBS3(4), THBS4(2), TNC(7), TNN(12), TNR(15), TNXB(42), VTN(2), VWF(11) 31894111 527 90 524 226 361 35 22 59 50 0 0.112 1.000 1.000 314 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(2), ACVR1B(1), ACVR2A(2), ACVR2B(2), AMHR2(5), BMP2(1), BMPR1A(1), BMPR2(2), CCL11(1), CCL18(1), CCL20(1), CCL24(2), CCL27(1), CCL7(1), CCR2(2), CCR3(5), CCR4(4), CCR6(1), CCR7(1), CCR8(2), CCR9(1), CD40(2), CNTF(1), CSF1(4), CSF1R(4), CSF2RA(5), CSF2RB(6), CX3CL1(1), CX3CR1(5), CXCL10(2), CXCL13(1), CXCR3(1), CXCR6(1), EDA(1), EDA2R(2), EGF(3), EGFR(4), EPO(2), FAS(1), FASLG(4), FLT1(8), FLT3(10), FLT3LG(2), FLT4(3), GDF5(5), GH1(2), GH2(2), GHR(8), HGF(7), IFNA1(1), IFNA16(3), IFNA21(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNAR1(1), IFNAR2(5), IFNB1(2), IFNG(1), IFNGR1(1), IFNGR2(2), IFNW1(1), IL10(1), IL10RA(2), IL10RB(1), IL11RA(1), IL12RB1(3), IL13RA1(1), IL15(1), IL15RA(3), IL17A(5), IL17B(1), IL18R1(4), IL18RAP(4), IL1A(1), IL1B(2), IL1R1(2), IL1R2(1), IL1RAP(1), IL20RA(2), IL21(2), IL21R(3), IL22RA1(4), IL23R(4), IL28B(1), IL28RA(1), IL29(1), IL2RA(1), IL2RB(2), IL3(2), IL3RA(3), IL4R(6), IL5(1), IL5RA(3), IL6R(1), IL6ST(5), IL7(2), IL7R(10), IL9R(1), INHBA(5), INHBB(2), INHBC(5), INHBE(1), KDR(8), LEP(1), LEPR(4), LIFR(11), LTB(1), MET(8), MPL(2), OSM(1), OSMR(10), PDGFC(3), PDGFRA(5), PDGFRB(3), PPBP(1), PRLR(9), TGFB3(2), TGFBR2(2), TNFRSF10A(3), TNFRSF11A(2), TNFRSF11B(3), TNFRSF13B(1), TNFRSF17(1), TNFRSF18(2), TNFRSF19(1), TNFRSF21(1), TNFRSF25(1), TNFRSF6B(2), TNFRSF8(7), TNFSF10(3), TNFSF11(2), TNFSF14(1), TNFSF15(2), TNFSF18(1), TNFSF8(1), TPO(12), VEGFA(2), VEGFB(1), VEGFC(6), XCL1(1), XCR1(1) 25132820 391 88 388 202 261 29 15 47 39 0 0.118 1.000 1.000 315 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 167 ADCY1(12), ADCY2(2), ADCY3(1), ADCY4(2), ADCY7(1), ADCY8(13), ADCY9(5), ADORA2A(1), ADRA1A(3), ADRA1D(1), AGTR1(2), ATP2A1(3), ATP2A2(6), ATP2A3(5), ATP2B1(1), ATP2B2(8), ATP2B3(1), ATP2B4(4), AVPR1B(1), BDKRB1(2), BDKRB2(2), CACNA1A(7), CACNA1B(5), CACNA1C(7), CACNA1D(4), CACNA1E(21), CACNA1F(1), CACNA1G(9), CACNA1H(8), CACNA1I(7), CACNA1S(17), CALM2(1), CALML3(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), CCKBR(2), CHP(1), CHRM2(3), CHRM3(8), CHRM5(1), CHRNA7(1), CYSLTR1(2), DRD1(1), EDNRA(4), EDNRB(3), EGFR(4), ERBB2(1), ERBB3(2), ERBB4(15), F2R(1), GNA15(3), GNAL(2), GNAQ(1), GNAS(5), GRIN2A(27), GRIN2C(2), GRIN2D(1), GRM1(4), GRM5(3), GRPR(2), HRH1(3), HTR2A(1), HTR2C(3), HTR4(3), HTR5A(3), HTR7(3), ITPKB(1), ITPR1(10), ITPR2(3), ITPR3(3), LHCGR(7), LTB4R2(1), MYLK(9), MYLK2(2), NOS1(17), NOS3(6), NTSR1(2), OXTR(1), P2RX2(2), P2RX3(1), P2RX4(1), P2RX5(1), P2RX7(1), PDE1A(13), PDE1B(5), PDE1C(10), PDGFRA(5), PDGFRB(3), PHKA1(5), PHKA2(3), PHKB(2), PHKG1(1), PHKG2(1), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PLCD4(2), PLCE1(10), PLCG1(6), PLCG2(6), PLCZ1(5), PPID(1), PPP3CA(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP3R2(1), PRKACA(2), PRKACB(3), PRKACG(3), PRKCA(2), PRKCG(5), PRKX(1), PTAFR(1), PTGER3(2), PTGFR(1), PTK2B(4), RYR1(27), RYR2(30), RYR3(22), SLC25A6(1), SLC8A1(5), SLC8A2(1), SLC8A3(5), SPHK1(1), SPHK2(1), TACR1(3), TACR2(1), TACR3(8), TNNC2(2), TRPC1(2) 37727402 615 86 609 365 427 46 22 65 55 0 0.0206 1.000 1.000 316 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 244 ACVR1B(1), ACVR1C(1), AKT1(3), AKT2(2), AKT3(1), ARRB1(1), ARRB2(1), ATF2(2), ATF4(2), BDNF(1), CACNA1A(7), CACNA1B(5), CACNA1C(7), CACNA1D(4), CACNA1E(21), CACNA1F(1), CACNA1G(9), CACNA1H(8), CACNA1I(7), CACNA1S(17), CACNA2D1(2), CACNA2D2(3), CACNA2D3(14), CACNA2D4(4), CACNB1(1), CACNB2(4), CACNB3(1), CACNB4(3), CACNG1(1), CACNG2(3), CACNG3(3), CACNG5(4), CACNG6(3), CACNG7(1), CASP3(1), CD14(1), CDC42(2), CHP(1), CHUK(1), CRKL(1), DAXX(1), DDIT3(1), DUSP14(1), DUSP16(2), DUSP3(1), DUSP6(1), DUSP7(1), DUSP8(2), ECSIT(1), EGF(3), EGFR(4), ELK1(1), ELK4(2), FAS(1), FASLG(4), FGF1(1), FGF10(1), FGF11(1), FGF12(3), FGF13(2), FGF16(2), FGF17(1), FGF18(2), FGF19(1), FGF21(1), FGF23(2), FGF4(1), FGF5(1), FGF6(1), FGF7(5), FGF9(2), FGFR1(4), FGFR2(7), FGFR3(4), FGFR4(2), FLNA(6), FLNB(8), FLNC(15), FOS(1), GNA12(1), GRB2(1), IKBKB(3), IL1A(1), IL1B(2), IL1R1(2), IL1R2(1), JUN(1), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(1), MAP2K6(1), MAP2K7(1), MAP3K1(1), MAP3K10(5), MAP3K12(1), MAP3K13(4), MAP3K2(3), MAP3K3(2), MAP3K4(5), MAP3K5(5), MAP4K1(3), MAP4K2(2), MAP4K3(2), MAP4K4(1), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK7(1), MAPK8IP1(1), MAPK8IP2(1), MAPK9(1), MAPKAPK2(2), MAPKAPK5(1), MAPT(1), MKNK1(2), MOS(1), MRAS(1), NF1(2), NFATC2(2), NFATC4(1), NFKB1(1), NFKB2(2), NLK(1), NR4A1(2), NRAS(1), NTF3(3), NTRK1(5), PAK1(2), PAK2(5), PDGFA(1), PDGFRA(5), PDGFRB(3), PLA2G2D(2), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), PPM1B(4), PPP3CA(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP3R2(1), PPP5C(1), PRKACA(2), PRKACB(3), PRKACG(3), PRKCA(2), PRKCG(5), PRKX(1), PTPN5(3), PTPN7(1), PTPRR(4), RAF1(3), RAPGEF2(2), RASA1(1), RASA2(4), RASGRF1(6), RASGRF2(4), RASGRP2(3), RASGRP3(3), RASGRP4(4), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), RPS6KA4(2), RPS6KA5(1), RPS6KA6(7), SOS1(3), SOS2(4), STK4(1), TAOK1(4), TAOK2(9), TAOK3(2), TGFB3(2), TGFBR2(2), TRAF6(1) 39717328 494 85 487 292 300 42 18 88 46 0 0.791 1.000 1.000 317 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 201 ACTN1(1), ACTN2(4), ACTN4(1), APC(6), APC2(3), ARAF(1), ARHGEF12(4), ARHGEF4(2), ARHGEF6(5), ARPC2(1), ARPC4(1), BAIAP2(3), BCAR1(1), BDKRB1(2), BDKRB2(2), CD14(1), CDC42(2), CFL1(1), CHRM2(3), CHRM3(8), CHRM4(1), CHRM5(1), CRKL(1), CSK(1), CYFIP1(1), CYFIP2(5), DIAPH2(2), DIAPH3(3), DOCK1(2), EGF(3), EGFR(4), F2(2), F2R(1), FGD3(1), FGF1(1), FGF10(1), FGF11(1), FGF12(3), FGF13(2), FGF16(2), FGF17(1), FGF18(2), FGF19(1), FGF21(1), FGF23(2), FGF4(1), FGF5(1), FGF6(1), FGF7(5), FGF9(2), FGFR1(4), FGFR2(7), FGFR3(4), FGFR4(2), FN1(9), GNA12(1), GRLF1(2), IQGAP1(2), IQGAP2(7), IQGAP3(2), ITGA1(3), ITGA10(1), ITGA11(6), ITGA2(2), ITGA2B(5), ITGA3(2), ITGA4(10), ITGA5(4), ITGA6(3), ITGA7(5), ITGA8(7), ITGA9(4), ITGAD(8), ITGAE(3), ITGAL(6), ITGAM(3), ITGAV(2), ITGAX(6), ITGB1(1), ITGB2(2), ITGB3(3), ITGB4(5), ITGB6(1), ITGB7(1), ITGB8(4), LIMK2(1), MAP2K1(3), MAP2K2(2), MAPK1(1), MOS(1), MRAS(1), MYH10(4), MYH14(5), MYH9(6), MYL2(1), MYL5(1), MYL7(1), MYL9(1), MYLK(9), MYLK2(2), NCKAP1(2), NCKAP1L(7), NRAS(1), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PAK7(10), PDGFA(1), PDGFRA(5), PDGFRB(3), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PIP4K2A(3), PIP4K2B(1), PIP4K2C(3), PIP5K1A(1), PIP5K1B(4), PIP5K1C(2), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP1R12B(4), PTK2(2), PXN(1), RAF1(3), RDX(1), RHOA(1), ROCK1(2), ROCK2(6), SCIN(1), SOS1(3), SOS2(4), SSH1(6), SSH3(2), TIAM1(2), TIAM2(5), VAV1(5), VAV3(1), VCL(2), WAS(2), WASF1(2), WASF2(3), WASL(1) 38813274 437 85 434 191 255 25 22 83 51 1 0.00713 1.000 1.000 318 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 126 ABL1(6), ABLIM1(1), ABLIM2(1), ABLIM3(3), ARHGEF12(4), CDC42(2), CDK5(1), CFL1(1), CHP(1), DCC(21), DPYSL2(1), DPYSL5(2), EFNA4(2), EFNA5(1), EFNB1(1), EFNB3(1), EPHA1(4), EPHA2(4), EPHA3(9), EPHA4(2), EPHA5(1), EPHA6(20), EPHA7(7), EPHA8(4), EPHB1(3), EPHB2(8), EPHB3(3), EPHB4(1), EPHB6(8), FES(2), FYN(1), GNAI1(1), GNAI3(1), GSK3B(1), ITGB1(1), L1CAM(2), LIMK2(1), LRRC4C(12), MAPK1(1), MET(8), NCK2(2), NFAT5(2), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), NGEF(4), NRAS(1), NRP1(4), NTN4(5), NTNG1(6), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PAK7(10), PLXNA1(6), PLXNA2(2), PLXNA3(1), PLXNB1(5), PLXNB2(5), PLXNB3(2), PLXNC1(4), PPP3CA(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP3R2(1), PTK2(2), RASA1(1), RGS3(4), RHOA(1), RND1(2), ROBO1(9), ROBO2(12), ROBO3(5), ROCK1(2), ROCK2(6), SEMA3A(3), SEMA3C(2), SEMA3D(3), SEMA3E(5), SEMA3F(2), SEMA3G(2), SEMA4A(1), SEMA4B(1), SEMA4C(1), SEMA4D(2), SEMA4F(3), SEMA4G(1), SEMA5A(2), SEMA5B(6), SEMA6A(3), SEMA6B(1), SEMA6C(3), SEMA6D(2), SEMA7A(1), SLIT1(3), SLIT2(18), SLIT3(15), SRGAP1(1), SRGAP2(2), SRGAP3(8), UNC5B(1), UNC5C(6), UNC5D(3) 27666434 393 84 388 216 265 28 10 61 29 0 0.451 1.000 1.000 319 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(3), AKT2(2), AKT3(1), CBL(1), CBLB(4), CBLC(3), CCND2(1), CCND3(1), CISH(2), CNTF(1), CREBBP(4), CSF2RA(5), CSF2RB(6), EP300(1), EPO(2), GH1(2), GH2(2), GHR(8), GRB2(1), IFNA1(1), IFNA16(3), IFNA21(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNAR1(1), IFNAR2(5), IFNB1(2), IFNG(1), IFNGR1(1), IFNGR2(2), IFNW1(1), IL10(1), IL10RA(2), IL10RB(1), IL11RA(1), IL12RB1(3), IL13RA1(1), IL13RA2(2), IL15(1), IL15RA(3), IL20RA(2), IL21(2), IL21R(3), IL22RA1(4), IL23R(4), IL28B(1), IL28RA(1), IL29(1), IL2RA(1), IL2RB(2), IL3(2), IL3RA(3), IL4R(6), IL5(1), IL5RA(3), IL6R(1), IL6ST(5), IL7(2), IL7R(10), IL9R(1), JAK1(2), JAK2(2), JAK3(1), LEP(1), LEPR(4), LIFR(11), MPL(2), OSM(1), OSMR(10), PIAS1(3), PIAS2(2), PIAS3(2), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PIM1(1), PRLR(9), PTPN11(2), PTPN6(2), SOCS2(1), SOCS3(1), SOCS5(1), SOS1(3), SOS2(4), SPRED1(1), SPRED2(1), SPRY1(1), SPRY2(3), SPRY3(5), STAM(1), STAM2(1), STAT2(4), STAT3(6), STAT4(9), STAT5A(1), STAT5B(1), STAT6(1), TPO(12), TYK2(1) 20687913 294 84 292 127 173 20 16 53 31 1 0.0989 1.000 1.000 320 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(6), APC2(3), AXIN1(3), AXIN2(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CCND2(1), CCND3(1), CER1(5), CHD8(5), CHP(1), CREBBP(4), CSNK1A1(1), CSNK1A1L(1), CSNK1E(1), CSNK2B(1), CTBP2(1), CTNNB1(6), CTNNBIP1(1), CUL1(2), DAAM1(2), DAAM2(2), DKK1(1), DKK2(2), DKK4(1), DVL3(4), EP300(1), FBXW11(1), FZD1(2), FZD2(2), FZD8(3), FZD9(1), GSK3B(1), JUN(1), LEF1(1), LRP5(3), LRP6(9), MAPK10(2), MAPK9(1), MMP7(1), NFAT5(2), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), NKD1(3), NKD2(3), NLK(1), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PORCN(3), PPP2R1A(1), PPP2R1B(1), PPP2R2B(1), PPP3CA(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP3R2(1), PRICKLE1(3), PRICKLE2(1), PRKACA(2), PRKACB(3), PRKACG(3), PRKCA(2), PRKCG(5), PRKX(1), PSEN1(1), RHOA(1), ROCK1(2), ROCK2(6), SENP2(3), SFRP2(3), SFRP4(3), SMAD2(1), SMAD3(1), SMAD4(2), TBL1X(3), TBL1Y(2), TCF7L1(1), TCF7L2(3), VANGL2(5), WNT1(1), WNT10A(1), WNT10B(2), WNT11(1), WNT2(1), WNT2B(3), WNT3(2), WNT5B(2), WNT7A(5), WNT7B(1), WNT8A(3), WNT8B(1), WNT9A(2), WNT9B(1) 22615898 250 83 246 107 138 24 10 49 29 0 0.0908 1.000 1.000 321 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA2(1), ACTN2(4), ACTN4(1), DES(1), DMD(9), FAM48A(1), MYBPC1(1), MYBPC2(6), MYBPC3(5), MYH3(6), MYH6(10), MYH7(10), MYH8(14), MYL1(1), MYL2(1), MYL9(1), MYOM1(5), NEB(27), TCAP(1), TNNC2(2), TNNI3(1), TNNT2(1), TPM1(1), TPM2(2), TPM3(2), TPM4(2), TTN(291), VIM(1) 19152984 408 81 396 170 293 24 14 51 23 3 0.00606 1.000 1.000 322 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(12), ADCY2(2), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(5), ADRA1A(3), ADRA1D(1), ANXA6(2), ARRB1(1), ARRB2(1), ATP1A4(3), ATP1B3(1), ATP2A2(6), ATP2A3(5), ATP2B1(1), ATP2B2(8), ATP2B3(1), CACNA1A(7), CACNA1B(5), CACNA1C(7), CACNA1D(4), CACNA1E(21), CACNA1S(17), CACNB1(1), CACNB3(1), CALM2(1), CALR(1), CAMK1(2), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), CASQ1(3), CASQ2(1), CHRM2(3), CHRM3(8), CHRM4(1), CHRM5(1), GJA1(1), GJA5(2), GJB3(1), GJB4(4), GJB6(1), GNAI3(1), GNAQ(1), GNAZ(2), GNB3(1), GNG2(1), GNG7(1), GRK4(3), GRK6(2), ITPR1(10), ITPR2(3), ITPR3(3), KCNB1(10), KCNJ3(5), KCNJ5(3), MIB1(2), NME7(1), PKIA(1), PKIB(1), PLCB3(2), PRKACA(2), PRKACB(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCA(2), PRKCD(2), PRKCE(2), PRKCG(5), PRKCH(4), PRKCQ(2), PRKD1(1), RGS1(1), RGS18(2), RGS3(4), RGS6(4), RGS7(13), RGS9(3), RYR1(27), RYR2(30), RYR3(22), SLC8A1(5), SLC8A3(5), YWHAB(1), YWHAQ(1) 26447165 373 80 365 253 251 39 13 38 32 0 0.628 1.000 1.000 323 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(4), CADM3(7), CD2(6), CD22(5), CD226(2), CD276(2), CD4(5), CD40(2), CD6(1), CD80(3), CD86(3), CD8A(1), CDH1(3), CDH2(6), CDH4(6), CDH5(2), CLDN1(3), CLDN10(2), CLDN11(1), CLDN16(4), CLDN18(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN4(1), CLDN6(3), CLDN9(1), CNTN1(9), CNTN2(5), CNTNAP1(5), CNTNAP2(17), F11R(3), GLG1(3), HLA-B(1), HLA-DMB(4), HLA-DOB(1), HLA-DPA1(1), HLA-DQA1(2), HLA-DQA2(2), HLA-DRA(3), HLA-DRB1(1), HLA-F(1), HLA-G(1), ICAM2(1), ICOS(1), ICOSLG(1), ITGA4(10), ITGA6(3), ITGA8(7), ITGA9(4), ITGAL(6), ITGAM(3), ITGAV(2), ITGB1(1), ITGB2(2), ITGB7(1), ITGB8(4), JAM2(4), JAM3(2), L1CAM(2), MADCAM1(1), MAG(2), MPZ(1), NCAM1(5), NCAM2(5), NEGR1(3), NEO1(3), NFASC(10), NLGN1(5), NLGN2(2), NLGN3(2), NRCAM(2), NRXN1(14), NRXN2(4), NRXN3(8), PDCD1(1), PDCD1LG2(1), PTPRC(16), PTPRF(7), PTPRM(3), PVR(1), PVRL1(1), PVRL2(1), SDC1(1), SDC2(1), SDC3(4), SDC4(1), SELE(4), SELL(3), SELP(11), SELPLG(3), SIGLEC1(4), SPN(2), VCAM1(3), VCAN(6) 20840174 332 80 325 129 213 27 17 59 16 0 0.000565 1.000 1.000 324 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 161 ADORA1(1), ADORA2A(1), ADORA3(3), ADRA1A(3), ADRA1D(1), ADRA2C(1), AGTR1(2), AGTR2(4), AVPR1B(1), AVPR2(1), BDKRB1(2), BDKRB2(2), BRS3(1), C3AR1(1), CCBP2(3), CCKBR(2), CCR10(1), CCR2(2), CCR3(5), CCR4(4), CCR6(1), CCR7(1), CCR8(2), CCR9(1), CCRL2(2), CHML(3), CHRM2(3), CHRM3(8), CHRM4(1), CHRM5(1), CMKLR1(3), CNR1(1), CNR2(1), CX3CR1(5), CXCR3(1), DRD1(1), DRD2(7), DRD5(8), EDNRA(4), EDNRB(3), F2R(1), F2RL1(3), F2RL2(2), F2RL3(2), FPR1(3), FSHR(5), GALR1(2), GALR3(1), GALT(1), GHSR(3), GPR173(1), GPR174(3), GPR37(4), GPR37L1(2), GPR50(4), GPR6(1), GPR63(1), GPR77(2), GPR83(2), GPR85(3), GPR87(2), GRPR(2), HCRTR1(2), HCRTR2(6), HRH1(3), HTR1A(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2C(3), HTR4(3), HTR5A(3), HTR7(3), LHCGR(7), MAS1(1), MC3R(1), MC5R(3), MTNR1A(1), MTNR1B(2), NMBR(4), NMUR1(4), NMUR2(3), NPY1R(9), NPY2R(3), NPY5R(8), NTSR1(2), NTSR2(1), OPN3(2), OPRD1(2), OPRK1(5), OPRL1(3), OPRM1(1), OR10A5(2), OR11A1(4), OR12D3(2), OR1C1(2), OR1F1(2), OR1Q1(3), OR2H1(3), OR5V1(1), OR8B8(4), OXTR(1), P2RY1(1), P2RY10(1), P2RY13(2), P2RY14(1), P2RY6(1), PPYR1(2), PTAFR(1), PTGDR(3), PTGER2(2), PTGFR(1), PTGIR(1), RGR(3), SSTR1(3), SSTR2(1), SSTR3(5), SUCNR1(3) 17091509 292 79 289 200 189 29 10 45 19 0 0.0231 1.000 1.000 325 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 129 ACTB(3), ACTG1(1), ACTN1(1), ACTN2(4), ACTN4(1), AKT1(3), AKT2(2), AKT3(1), ASH1L(7), CASK(1), CDC42(2), CGN(4), CLDN1(3), CLDN10(2), CLDN11(1), CLDN16(4), CLDN18(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN4(1), CLDN6(3), CLDN9(1), CRB3(1), CSNK2B(1), CTNNA2(3), CTNNA3(4), CTNNB1(6), EPB41(4), EPB41L1(3), EPB41L2(5), EPB41L3(2), EXOC3(1), EXOC4(5), F11R(3), GNAI1(1), GNAI3(1), HCLS1(1), IGSF5(3), INADL(13), JAM2(4), JAM3(2), LLGL1(2), LLGL2(2), MAGI1(11), MAGI2(4), MAGI3(8), MLLT4(2), MPDZ(2), MPP5(1), MRAS(1), MYH1(29), MYH10(4), MYH11(5), MYH13(12), MYH14(5), MYH15(13), MYH2(17), MYH3(6), MYH4(19), MYH6(10), MYH7(10), MYH7B(9), MYH8(14), MYH9(6), MYL2(1), MYL5(1), MYL7(1), MYL9(1), NRAS(1), PARD3(4), PARD6G(1), PPP2R1A(1), PPP2R1B(1), PPP2R2B(1), PPP2R3A(1), PPP2R3B(1), PRKCA(2), PRKCD(2), PRKCE(2), PRKCG(5), PRKCH(4), PRKCI(3), PRKCQ(2), RAB3B(1), RHOA(1), SPTAN1(2), SYMPK(2), TJP1(4), TJP2(2), TJP3(5), YES1(4) 27287911 361 79 357 208 234 29 10 52 36 0 0.377 1.000 1.000 326 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA2(1), ADCY1(12), ADCY2(2), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(5), ARRB1(1), ARRB2(1), ATF1(3), ATF2(2), ATF4(2), ATF5(3), ATP2A2(6), ATP2A3(5), CACNB3(1), CALCA(2), CALM2(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CORIN(3), CRH(2), CRHR1(1), DGKZ(2), ETS2(2), FOS(1), GABPB2(2), GBA2(1), GJA1(1), GNAQ(1), GNB3(1), GNG2(1), GNG7(1), GRK4(3), GRK6(2), GUCA2A(1), GUCY1A3(6), IGFBP1(1), IGFBP6(2), IL1B(2), ITPR1(10), ITPR2(3), ITPR3(3), JUN(1), MIB1(2), MYL2(1), MYLK2(2), NFKB1(1), NOS1(17), NOS3(6), OXTR(1), PDE4B(3), PDE4D(4), PKIA(1), PKIB(1), PLCB3(2), PLCG1(6), PLCG2(6), PRKACA(2), PRKACB(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCA(2), PRKCD(2), PRKCE(2), PRKCH(4), PRKCQ(2), PRKD1(1), RAMP2(1), RAMP3(1), RGS1(1), RGS18(2), RGS3(4), RGS6(4), RGS7(13), RGS9(3), RYR1(27), RYR2(30), RYR3(22), SLC8A1(5), TNXB(42), YWHAB(1), YWHAQ(1) 24741667 360 79 350 179 248 31 11 42 28 0 0.00797 1.000 1.000 327 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(12), ADCY2(2), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(5), ADK(2), ADSL(1), ADSS(2), ADSSL1(5), AK2(1), AK5(3), AK7(3), ALLC(2), AMPD1(7), AMPD2(2), AMPD3(7), APRT(2), ATIC(2), CANT1(1), ENPP1(4), ENPP3(4), ENTPD1(2), ENTPD3(2), ENTPD4(1), ENTPD6(1), ENTPD8(1), FHIT(1), GART(2), GDA(4), GUCY1A2(5), GUCY1A3(6), GUCY2C(7), GUCY2D(3), GUCY2F(3), GUK1(2), NME7(1), NPR1(4), NPR2(4), NT5C1A(1), NT5C1B(6), NT5C2(2), NT5E(1), NUDT5(1), NUDT9(1), PAPSS1(1), PDE10A(5), PDE11A(6), PDE1A(13), PDE1C(10), PDE2A(3), PDE3B(3), PDE4A(3), PDE4B(3), PDE4C(4), PDE4D(4), PDE5A(2), PDE6D(1), PDE6G(1), PDE7A(1), PDE7B(5), PDE8A(1), PDE8B(6), PDE9A(5), PFAS(1), PKLR(2), PKM2(1), POLA1(1), POLA2(2), POLD1(2), POLD3(1), POLE(4), POLE2(1), POLR1A(2), POLR1B(1), POLR2A(4), POLR2B(4), POLR2C(1), POLR2D(1), POLR2H(2), POLR3B(7), POLR3H(1), PRIM1(2), PRIM2(5), PRPS1(2), PRPS1L1(2), PRPS2(1), RRM1(1), RRM2(2), RRM2B(2), XDH(8) 23272006 289 76 288 141 184 27 19 32 27 0 0.0898 1.000 1.000 328 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 79 AGL(3), AMY2A(1), AMY2B(5), ASCC3(2), ATP13A2(3), DDX18(2), DDX23(3), DDX4(2), DDX41(3), DDX51(2), DDX52(1), DDX54(1), DDX55(1), DHX58(3), ENPP1(4), ENPP3(4), ENTPD7(1), EP400(7), ERCC2(1), ERCC3(1), G6PC2(2), GAA(1), GANC(4), GBA3(4), GBE1(2), GCK(5), GPI(1), GUSB(3), GYS1(2), GYS2(3), HK1(2), HK2(4), HK3(3), IFIH1(7), MGAM(39), MOV10L1(7), NUDT5(1), PGM1(3), PYGL(1), PYGM(1), RAD54B(2), RUVBL2(2), SETX(7), SI(18), SKIV2L2(2), SMARCA2(2), SMARCA5(4), TREH(1), UGDH(1), UGT1A1(2), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(1), UGT1A8(2), UGT1A9(4), UGT2A1(5), UGT2A3(8), UGT2B10(15), UGT2B11(3), UGT2B28(5), UGT2B4(7), UGT2B7(5), UXS1(2) 17236487 251 75 247 107 157 17 11 40 26 0 0.0762 1.000 1.000 329 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(4), CD14(1), CD19(4), CD1A(2), CD1B(6), CD1C(8), CD1E(8), CD2(6), CD22(5), CD33(5), CD37(2), CD4(5), CD44(2), CD55(2), CD8A(1), CR1(14), CR2(8), CSF1(4), CSF1R(4), CSF2RA(5), DNTT(1), EPO(2), FCER2(2), FCGR1A(1), FLT3(10), FLT3LG(2), GP9(1), GYPA(2), HLA-DRA(3), HLA-DRB1(1), IL11RA(1), IL1A(1), IL1B(2), IL1R1(2), IL1R2(1), IL2RA(1), IL3(2), IL3RA(3), IL4R(6), IL5(1), IL5RA(3), IL6R(1), IL7(2), IL7R(10), IL9R(1), ITGA1(3), ITGA2(2), ITGA2B(5), ITGA3(2), ITGA4(10), ITGA5(4), ITGA6(3), ITGAM(3), ITGB3(3), MME(6), MS4A1(1), TFRC(3), THPO(2), TPO(12) 11570469 217 75 213 87 153 10 11 23 20 0 0.00982 1.000 1.000 330 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 130 ACACA(6), ACACB(3), AKT1(3), AKT2(2), AKT3(1), ARAF(1), CALM2(1), CALML3(1), CBL(1), CBLB(4), CBLC(3), CRKL(1), ELK1(1), EXOC7(3), FASN(5), FBP1(1), FBP2(1), FLOT1(1), FOXO1(1), G6PC2(2), GCK(5), GRB2(1), GSK3B(1), GYS1(2), GYS2(3), IKBKB(3), INPP5D(6), INSR(6), IRS1(1), IRS4(3), LIPE(4), MAP2K1(3), MAP2K2(2), MAPK1(1), MAPK10(2), MAPK9(1), MKNK1(2), NRAS(1), PCK1(3), PCK2(1), PDE3A(3), PDE3B(3), PDPK1(1), PFKL(2), PFKM(1), PHKA1(5), PHKA2(3), PHKB(2), PHKG1(1), PHKG2(1), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PKLR(2), PKM2(1), PPARGC1A(2), PPP1CB(1), PPP1CC(1), PPP1R3A(10), PPP1R3B(3), PPP1R3C(1), PPP1R3D(2), PRKAA2(6), PRKAB1(1), PRKACA(2), PRKACB(3), PRKACG(3), PRKAG1(1), PRKAG2(3), PRKAG3(2), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCI(3), PRKX(1), PTPRF(7), PYGL(1), PYGM(1), RAF1(3), RAPGEF1(3), SHC2(2), SHC3(2), SLC2A4(3), SOCS2(1), SOCS3(1), SORBS1(3), SOS1(3), SOS2(4), SREBF1(1), TRIP10(1), TSC1(1), TSC2(3) 22478023 243 75 240 99 137 17 12 47 29 1 0.0340 1.000 1.000 331 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(12), ADCY2(2), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(5), DRD1(1), DRD2(7), EGF(3), EGFR(4), GJA1(1), GJD2(1), GNAI1(1), GNAI3(1), GNAQ(1), GNAS(5), GRB2(1), GRM1(4), GRM5(3), GUCY1A2(5), GUCY1A3(6), GUCY2C(7), GUCY2D(3), GUCY2F(3), HTR2A(1), HTR2C(3), ITPR1(10), ITPR2(3), ITPR3(3), MAP2K1(3), MAP2K2(2), MAP3K2(3), MAPK1(1), MAPK7(1), NPR1(4), NPR2(4), NRAS(1), PDGFA(1), PDGFC(3), PDGFD(1), PDGFRA(5), PDGFRB(3), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PRKACA(2), PRKACB(3), PRKACG(3), PRKCA(2), PRKCG(5), PRKG1(2), PRKG2(4), PRKX(1), RAF1(3), SOS1(3), SOS2(4), TJP1(4), TUBA1C(1), TUBA3C(3), TUBA3D(2), TUBA4A(1), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(1), TUBB3(1), TUBB4(2), TUBB4Q(3), TUBB6(2), TUBB8(1) 18698473 244 74 239 130 153 24 12 32 23 0 0.188 1.000 1.000 332 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(6), BDKRB1(2), BDKRB2(2), C1QA(2), C1QC(2), C1R(3), C1S(3), C2(3), C3(9), C3AR1(1), C4BPA(5), C4BPB(2), C5(4), C5AR1(3), C6(21), C7(11), C8A(8), C8B(14), C8G(1), C9(4), CD55(2), CFB(4), CFH(8), CFI(3), CR1(14), CR2(8), F10(3), F11(3), F13A1(9), F13B(7), F2(2), F2R(1), F5(9), F7(1), F8(19), F9(2), FGA(8), FGB(5), FGG(3), KLKB1(5), KNG1(2), MASP1(1), MBL2(5), PLAU(1), PLAUR(1), PLG(4), PROC(2), PROS1(7), SERPINA1(2), SERPINA5(1), SERPINC1(2), SERPIND1(1), SERPINE1(1), SERPING1(3), TFPI(1), VWF(11) 12858973 267 74 263 102 182 18 13 35 18 1 0.00822 1.000 1.000 333 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(4), ABCA10(10), ABCA12(10), ABCA13(12), ABCA2(3), ABCA3(3), ABCA4(11), ABCA5(2), ABCA6(8), ABCA7(2), ABCA8(10), ABCA9(7), ABCB1(9), ABCB10(3), ABCB11(5), ABCB4(4), ABCB5(12), ABCB6(1), ABCB7(1), ABCB8(1), ABCB9(2), ABCC1(4), ABCC10(5), ABCC11(2), ABCC12(6), ABCC2(2), ABCC3(6), ABCC5(5), ABCC6(8), ABCC8(9), ABCC9(18), ABCD2(4), ABCD3(4), ABCD4(1), ABCG1(3), ABCG4(3), ABCG8(3), CFTR(11), TAP2(5) 16810113 219 72 217 135 132 16 6 35 30 0 0.624 1.000 1.000 334 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 66 ADCY1(12), ADCY8(13), ARAF(1), ATF4(2), CACNA1C(7), CALM2(1), CALML3(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), CHP(1), CREBBP(4), EP300(1), GNAQ(1), GRIA1(10), GRIA2(14), GRIN2A(27), GRIN2B(16), GRIN2C(2), GRIN2D(1), GRM1(4), GRM5(3), ITPR1(10), ITPR2(3), ITPR3(3), MAP2K1(3), MAP2K2(2), MAPK1(1), NRAS(1), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP3CA(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP3R2(1), PRKACA(2), PRKACB(3), PRKACG(3), PRKCA(2), PRKCG(5), PRKX(1), RAF1(3), RAPGEF3(5), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), RPS6KA6(7) 13791901 242 72 238 122 155 20 11 36 20 0 0.101 1.000 1.000 335 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 73 ARAF(1), CACNA1A(7), CRH(2), CRHR1(1), GNA12(1), GNAI1(1), GNAI3(1), GNAQ(1), GNAS(5), GNAZ(2), GRIA1(10), GRIA2(14), GRIA3(6), GRID2(14), GRM1(4), GRM5(3), GUCY1A2(5), GUCY1A3(6), GUCY2C(7), GUCY2D(3), GUCY2F(3), IGF1(5), IGF1R(4), ITPR1(10), ITPR2(3), ITPR3(3), LYN(2), MAP2K1(3), MAP2K2(2), MAPK1(1), NOS1(17), NOS3(6), NPR1(4), NPR2(4), NRAS(1), PLA2G2D(2), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PPP2R1A(1), PPP2R1B(1), PPP2R2B(1), PRKCA(2), PRKCG(5), PRKG1(2), PRKG2(4), RAF1(3), RYR1(27) 15339127 257 71 252 118 186 15 7 28 21 0 0.00464 1.000 1.000 336 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(12), ADCY2(2), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(5), AKAP1(2), AKAP10(2), AKAP11(5), AKAP12(1), AKAP3(6), AKAP4(6), AKAP6(9), AKAP7(1), AKAP8(2), AKAP9(6), CALM2(1), GNA12(1), GNA15(3), GNAI3(1), GNAL(2), GNAQ(1), GNAZ(2), GNB3(1), GNG7(1), GNGT2(1), ITPR1(10), KCNJ3(5), NRAS(1), PDE1A(13), PDE1B(5), PDE1C(10), PDE4A(3), PDE4B(3), PDE4C(4), PDE4D(4), PDE7A(1), PDE7B(5), PDE8A(1), PDE8B(6), PLCB3(2), PPP3CA(4), PPP3CC(1), PRKACA(2), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCA(2), PRKCD(2), PRKCE(2), PRKCG(5), PRKCH(4), PRKCI(3), PRKCQ(2), PRKD1(1), PRKD3(2), RHOA(1) 16632685 208 70 208 84 134 16 11 29 18 0 0.00477 1.000 1.000 337 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(1), ACTN2(4), ACTN4(1), ARHGAP5(3), BCAR1(1), CDC42(2), CDH5(2), CLDN1(3), CLDN10(2), CLDN11(1), CLDN16(4), CLDN18(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN4(1), CLDN6(3), CLDN9(1), CTNNA2(3), CTNNA3(4), CTNNB1(6), CTNND1(1), CYBB(2), F11R(3), GNAI1(1), GNAI3(1), GRLF1(2), ITGA4(10), ITGAL(6), ITGAM(3), ITGB1(1), ITGB2(2), ITK(2), JAM2(4), JAM3(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MLLT4(2), MMP2(3), MYL2(1), MYL5(1), MYL7(1), MYL9(1), NCF2(2), NCF4(2), NOX1(3), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PLCG1(6), PLCG2(6), PRKCA(2), PRKCG(5), PTK2(2), PTK2B(4), PTPN11(2), PXN(1), RAPGEF3(5), RAPGEF4(2), RASSF5(2), RHOA(1), RHOH(4), ROCK1(2), ROCK2(6), SIPA1(2), VASP(1), VAV1(5), VAV3(1), VCAM1(3), VCL(2) 17517996 208 70 208 89 118 14 9 49 17 1 0.0586 1.000 1.000 338 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 68 ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH5(1), ADH6(3), ADH7(5), AKR1C2(1), AKR1C3(2), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), CYP1A1(2), CYP1A2(5), CYP1B1(1), CYP2B6(5), CYP2C18(7), CYP2C19(6), CYP2C8(7), CYP2C9(10), CYP2E1(5), CYP2F1(4), CYP2S1(2), CYP3A4(8), CYP3A43(7), CYP3A5(5), CYP3A7(1), DHDH(1), GSTA1(2), GSTM3(1), GSTM5(1), GSTP1(1), MGST1(1), MGST2(1), MGST3(1), UGT1A1(2), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(1), UGT1A8(2), UGT1A9(4), UGT2A1(5), UGT2A3(8), UGT2B10(15), UGT2B11(3), UGT2B28(5), UGT2B4(7), UGT2B7(5) 7881882 184 69 179 75 138 14 7 15 10 0 0.00126 1.000 1.000 339 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 107 ABL1(6), ANAPC1(8), ANAPC4(1), ANAPC5(2), ANAPC7(3), ATM(6), ATR(6), BUB1(1), BUB1B(5), CCNA1(8), CCNB2(3), CCNB3(8), CCND2(1), CCND3(1), CCNE1(1), CCNE2(5), CDC14A(2), CDC23(2), CDC25A(1), CDC7(1), CDK6(1), CDKN1A(1), CHEK1(1), CHEK2(1), CREBBP(4), CUL1(2), DBF4(4), E2F2(1), E2F3(4), EP300(1), ESPL1(4), FZR1(2), GSK3B(1), HDAC1(1), HDAC2(1), MAD2L2(1), MCM2(2), MCM3(1), MCM4(2), MCM5(1), MCM6(1), MDM2(2), ORC1L(1), ORC4L(1), PCNA(2), PKMYT1(2), PLK1(1), PRKDC(6), PTTG2(2), RB1(2), RBL1(5), RBL2(2), SMAD2(1), SMAD3(1), SMAD4(2), SMC1A(1), SMC1B(11), TGFB3(2), YWHAB(1), YWHAQ(1) 19168838 154 69 153 62 74 10 10 48 11 1 0.318 1.000 1.000 340 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 97 AKT1(3), AKT2(2), AKT3(1), CASP8(4), CD14(1), CD40(2), CD80(3), CD86(3), CHUK(1), CXCL10(2), FOS(1), IFNA1(1), IFNA16(3), IFNA21(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNAR1(1), IFNAR2(5), IFNB1(2), IKBKB(3), IKBKE(4), IL1B(2), IRAK1(3), IRAK4(1), IRF3(1), IRF7(2), JUN(1), LBP(2), LY96(3), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(1), MAP2K6(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK9(1), NFKB1(1), NFKB2(2), NFKBIA(1), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), RELA(2), SPP1(1), TBK1(2), TICAM1(2), TIRAP(1), TLR1(4), TLR2(2), TLR3(4), TLR4(6), TLR5(3), TLR6(4), TLR7(8), TLR9(3), TOLLIP(1), TRAF3(2), TRAF6(1) 12677316 172 69 169 56 86 14 11 43 17 1 0.00158 1.000 1.000 341 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(12), ADCY2(2), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(5), ATF4(2), CACNA1C(7), CACNA1D(4), CACNA1F(1), CACNA1S(17), CALM2(1), CALML3(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CDC42(2), EGFR(4), ELK1(1), FSHB(2), GNAQ(1), GNAS(5), GNRH2(1), GNRHR(1), GRB2(1), HBEGF(1), ITPR1(10), ITPR2(3), ITPR3(3), JUN(1), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(1), MAP2K6(1), MAP2K7(1), MAP3K1(1), MAP3K2(3), MAP3K3(2), MAP3K4(5), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK7(1), MAPK9(1), MMP2(3), NRAS(1), PLA2G2D(2), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PLD1(5), PLD2(1), PRKACA(2), PRKACB(3), PRKACG(3), PRKCA(2), PRKCD(2), PRKX(1), PTK2B(4), RAF1(3), SOS1(3), SOS2(4) 17901252 235 69 231 133 138 27 14 33 23 0 0.306 1.000 1.000 342 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(12), ADCY2(2), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(5), CALM2(1), CALML3(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CREB3L3(3), CREB3L4(3), CREBBP(4), CTNNB1(6), DCT(1), DVL3(4), EDN1(3), EDNRB(3), EP300(1), FZD1(2), FZD2(2), FZD8(3), FZD9(1), GNAI1(1), GNAI3(1), GNAQ(1), GNAS(5), GSK3B(1), LEF1(1), MAP2K1(3), MAP2K2(2), MAPK1(1), MITF(1), NRAS(1), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PRKACA(2), PRKACB(3), PRKACG(3), PRKCA(2), PRKCG(5), PRKX(1), RAF1(3), TCF7L1(1), TCF7L2(3), TYR(4), TYRP1(3), WNT1(1), WNT10A(1), WNT10B(2), WNT11(1), WNT2(1), WNT2B(3), WNT3(2), WNT5B(2), WNT7A(5), WNT7B(1), WNT8A(3), WNT8B(1), WNT9A(2), WNT9B(1) 15336904 197 69 192 96 110 20 11 27 29 0 0.100 1.000 1.000 343 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 106 A4GNT(3), ALG1(1), ALG10(1), ALG10B(3), ALG12(1), ALG13(3), ALG14(1), ALG2(2), ALG3(1), ALG6(1), ALG8(4), ALG9(4), B3GNT1(2), B3GNT2(1), B3GNT7(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), B4GALT4(1), C1GALT1(1), CHPF(2), CHST1(1), CHST11(3), CHST12(1), CHST13(1), CHST14(1), CHST4(3), CHST6(1), CHSY1(2), DDOST(1), DPAGT1(1), EXT2(3), EXTL1(1), EXTL3(3), FUT11(1), FUT8(2), GALNT1(1), GALNT10(5), GALNT12(2), GALNT13(7), GALNT14(5), GALNT2(1), GALNT5(3), GALNT6(2), GALNT7(2), GALNT8(5), GALNT9(2), GALNTL1(1), GALNTL2(3), GALNTL4(2), GALNTL5(6), GANAB(2), GCNT1(3), GCNT3(4), GCNT4(1), HS3ST1(3), HS3ST2(1), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(1), HS6ST1(2), HS6ST3(4), MAN1A1(5), MAN1A2(1), MAN2A1(4), MGAT1(1), MGAT3(2), MGAT4A(3), MGAT4B(1), MGAT5B(5), NDST1(1), NDST2(1), NDST3(7), NDST4(15), OGT(2), ST3GAL2(1), ST3GAL3(1), ST6GAL1(1), ST6GALNAC1(2), STT3B(2), XYLT1(2), XYLT2(1) 15359265 189 68 187 76 123 14 7 21 24 0 0.00587 1.000 1.000 344 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 91 AKT1(3), AKT2(2), AKT3(1), CARD11(5), CBL(1), CBLB(4), CBLC(3), CD4(5), CD8A(1), CDC42(2), CHP(1), CHUK(1), FOS(1), FYN(1), GRAP2(1), GRB2(1), ICOS(1), IFNG(1), IKBKB(3), IL10(1), IL5(1), ITK(2), JUN(1), LAT(1), LCK(1), LCP2(4), MALT1(1), NCK2(2), NFAT5(2), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), NFKB1(1), NFKB2(2), NFKBIA(1), NRAS(1), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PAK7(10), PDCD1(1), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PLCG1(6), PPP3CA(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP3R2(1), PRKCQ(2), PTPN6(2), PTPRC(16), RHOA(1), SOS1(3), SOS2(4), TEC(4), VAV1(5), VAV3(1) 14337750 185 66 183 59 104 11 13 44 12 1 0.00322 1.000 1.000 345 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 89 AKT1(3), AKT3(1), BCAR1(1), CAPN1(2), CAPN10(3), CAPN11(3), CAPN2(2), CAPN3(2), CAPN5(1), CAPN6(3), CAPN7(1), CAPN9(4), CDC42(2), CSK(1), DOCK1(2), FYN(1), GIT2(2), GRB2(1), ITGA10(1), ITGA11(6), ITGA2(2), ITGA2B(5), ITGA3(2), ITGA4(10), ITGA5(4), ITGA6(3), ITGA7(5), ITGA8(7), ITGA9(4), ITGAD(8), ITGAE(3), ITGAL(6), ITGAM(3), ITGAV(2), ITGAX(6), ITGB1(1), ITGB2(2), ITGB3(3), ITGB4(5), ITGB6(1), ITGB7(1), ITGB8(4), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K6(1), MAPK10(2), MAPK12(1), MAPK4(5), MAPK6(2), MAPK7(1), MYLK2(2), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PDPK1(1), PIK3R2(3), PTK2(2), PXN(1), RAPGEF1(3), ROCK1(2), ROCK2(6), SHC3(2), SORBS1(3), SOS1(3), TLN1(2), TNS1(3), VASP(1), VAV3(1), VCL(2), ZYX(2) 18804897 202 66 200 84 116 18 13 37 18 0 0.0337 1.000 1.000 346 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(12), ADCY2(2), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(13), ADK(2), ADSL(1), ADSS(2), AK2(1), AK5(3), ALLC(2), AMPD1(7), AMPD2(2), AMPD3(7), APRT(2), ATIC(2), ATP5C1(1), ATP5F1(2), ATP5J(1), CANT1(1), ENPP1(4), ENPP3(4), ENTPD1(2), FHIT(1), GART(2), GDA(4), GUCY1A2(5), GUCY1A3(6), GUCY2C(7), GUCY2D(3), GUCY2F(3), GUK1(2), NPR1(4), NPR2(4), NT5E(1), PAPSS1(1), PDE1A(13), PDE4A(3), PDE4B(3), PDE4C(4), PDE4D(4), PDE5A(2), PDE6B(2), PDE6C(7), PDE6G(1), PDE7B(5), PDE8A(1), PDE9A(5), PFAS(1), PKLR(2), PKM2(1), POLD1(2), POLE(4), POLG(4), POLL(1), POLQ(7), POLR1B(1), POLR2A(4), POLR2B(4), POLR2C(1), POLR2D(1), POLR2H(2), POLRMT(1), PRPS1(2), PRPS1L1(2), PRPS2(1), RRM1(1), RRM2(2) 18200006 218 66 217 106 143 16 10 26 23 0 0.0913 1.000 1.000 347 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CALM2(1), CALML3(1), CDS1(2), CDS2(2), DGKA(1), DGKB(7), DGKD(2), DGKE(1), DGKG(6), DGKI(11), DGKQ(3), DGKZ(2), IMPA1(1), IMPA2(1), INPP1(1), INPP4A(3), INPP4B(1), INPP5A(1), INPP5B(1), INPP5D(6), INPPL1(5), ITPK1(1), ITPKB(1), ITPR1(10), ITPR2(3), ITPR3(3), OCRL(1), PI4KA(2), PI4KB(1), PIK3C2A(2), PIK3C2B(4), PIK3C2G(10), PIK3C3(1), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PIP4K2A(3), PIP4K2B(1), PIP4K2C(3), PIP5K1A(1), PIP5K1B(4), PIP5K1C(2), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PLCD4(2), PLCE1(10), PLCG1(6), PLCG2(6), PLCZ1(5), PRKCA(2), PRKCG(5), SYNJ1(7), SYNJ2(2) 17494305 231 65 228 91 142 12 11 43 22 1 0.00433 1.000 1.000 348 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(6), ACTN1(1), AKT1(3), AKT2(2), AKT3(1), ANGPTL2(1), ARHGEF6(5), BCAR1(1), CDC42(2), CSE1L(3), DOCK1(2), EPHB2(8), FYN(1), GRB2(1), GRB7(1), GRLF1(2), ITGA1(3), ITGA10(1), ITGA11(6), ITGA2(2), ITGA3(2), ITGA4(10), ITGA5(4), ITGA6(3), ITGA7(5), ITGA8(7), ITGA9(4), ITGB3BP(1), MAP2K4(1), MAP2K7(1), MAP3K11(1), MAPK1(1), MAPK10(2), MAPK8IP1(1), MAPK8IP2(1), MAPK9(1), MRAS(1), MYLK(9), MYLK2(2), P4HB(1), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PAK7(10), PIK3CA(3), PIK3CB(9), PKLR(2), PLCG1(6), PLCG2(6), PTK2(2), RAF1(3), RALA(1), ROCK1(2), ROCK2(6), SOS1(3), SOS2(4), TLN1(2), TLN2(11), VASP(1), WAS(2), ZYX(2) 16886959 198 65 198 78 110 15 13 45 15 0 0.0294 1.000 1.000 349 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 40 AGL(3), AMY2A(1), AMY2B(5), ENPP1(4), ENPP3(4), GAA(1), GANAB(2), GBA3(4), GBE1(2), GCK(5), GPI(1), GUSB(3), GYS1(2), GYS2(3), HK1(2), HK2(4), HK3(3), MGAM(39), PGM1(3), PYGL(1), PYGM(1), SI(18), UGDH(1), UGT1A1(2), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(1), UGT1A8(2), UGT1A9(4), UGT2B4(7), UXS1(2) 7796942 138 65 138 63 89 9 6 21 13 0 0.219 1.000 1.000 350 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 84 ABL1(6), ABL2(1), AKT1(3), AKT2(2), AKT3(1), ARAF(1), AREG(2), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CBL(1), CBLB(4), CBLC(3), CDKN1A(1), CRKL(1), EGF(3), EGFR(4), ELK1(1), ERBB2(1), ERBB3(2), ERBB4(15), EREG(1), GRB2(1), GSK3B(1), HBEGF(1), JUN(1), MAP2K1(3), MAP2K2(2), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK9(1), NCK2(2), NRAS(1), NRG1(4), NRG2(3), NRG3(5), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PAK7(10), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PLCG1(6), PLCG2(6), PRKCA(2), PRKCG(5), PTK2(2), RAF1(3), SHC2(2), SHC3(2), SOS1(3), SOS2(4), STAT5A(1), STAT5B(1), TGFA(2) 14361165 188 64 185 71 102 12 11 41 21 1 0.0500 1.000 1.000 351 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(14), COL4A2(8), COL4A3(13), COL4A4(22), COL4A5(20), COL4A6(6), F10(3), F11(3), F2(2), F2R(1), F5(9), F8(19), F9(2), FGA(8), FGB(5), FGG(3), KLKB1(5), PROC(2), PROS1(7), SERPINC1(2), SERPING1(3) 6333672 157 64 155 42 115 13 5 16 8 0 0.0558 1.000 1.000 352 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 123 ARAF(1), CASP3(1), CD244(2), CD48(2), CHP(1), FAS(1), FASLG(4), FCGR3A(1), FCGR3B(1), FYN(1), GRB2(1), GZMB(1), HLA-B(1), HLA-G(1), ICAM2(1), IFNA1(1), IFNA16(3), IFNA21(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNAR1(1), IFNAR2(5), IFNB1(2), IFNG(1), IFNGR1(1), IFNGR2(2), ITGAL(6), ITGB2(2), KIR2DL1(5), KIR2DL3(2), KIR2DL4(1), KIR3DL1(4), KLRC1(2), KLRC3(4), KLRD1(1), KLRK1(1), LAT(1), LCK(1), LCP2(4), MAP2K1(3), MAP2K2(2), MAPK1(1), NCR2(1), NCR3(1), NFAT5(2), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), NRAS(1), PAK1(2), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PLCG1(6), PLCG2(6), PPP3CA(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP3R2(1), PRKCA(2), PRKCG(5), PTK2B(4), PTPN11(2), PTPN6(2), RAF1(3), SHC2(2), SHC3(2), SOS1(3), SOS2(4), SYK(5), TNFRSF10A(3), TNFSF10(3), ULBP1(2), ULBP3(2), VAV1(5), VAV3(1) 15654675 211 63 209 76 122 12 8 49 19 1 0.00725 1.000 1.000 353 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 61 AKT1(3), AKT2(2), AKT3(1), BLNK(2), BTK(5), CARD11(5), CD19(4), CD22(5), CD72(2), CD79A(1), CHP(1), CHUK(1), CR2(8), FCGR2B(1), FOS(1), GSK3B(1), IKBKB(3), INPP5D(6), JUN(1), LILRB3(2), LYN(2), MALT1(1), NFAT5(2), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), NFKB1(1), NFKB2(2), NFKBIA(1), NRAS(1), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PLCG2(6), PPP3CA(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP3R2(1), PTPN6(2), RASGRP3(3), SYK(5), VAV1(5), VAV3(1) 10532079 145 63 145 43 83 7 7 38 9 1 0.00159 1.000 1.000 354 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(2), ACVR1B(1), ACVR1C(1), ACVR2A(2), ACVR2B(2), ACVRL1(3), AMHR2(5), BMP2(1), BMP5(4), BMP6(3), BMP8A(1), BMP8B(1), BMPR1A(1), BMPR2(2), CHRD(2), COMP(4), CREBBP(4), CUL1(2), DCN(7), EP300(1), FST(1), GDF5(5), GDF6(2), IFNG(1), INHBA(5), INHBB(2), INHBC(5), INHBE(1), LEFTY1(3), LEFTY2(1), LTBP1(11), MAPK1(1), NODAL(1), PITX2(1), PPP2R1A(1), PPP2R1B(1), PPP2R2B(1), RBL1(5), RBL2(2), RHOA(1), ROCK1(2), ROCK2(6), SMAD1(2), SMAD2(1), SMAD3(1), SMAD4(2), SMAD5(1), SMAD6(1), SMAD7(1), SMAD9(2), SMURF2(1), TGFB3(2), TGFBR2(2), THBS1(8), THBS2(5), THBS3(4), THBS4(2), ZFYVE16(1), ZFYVE9(2) 14108978 146 62 144 62 90 11 1 27 17 0 0.224 1.000 1.000 355 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(7), CARM1(1), CTCFL(3), DOT1L(3), EHMT1(1), EHMT2(5), EZH1(2), EZH2(4), FBXO11(1), HCFC1(4), JMJD4(1), KDM6A(1), MEN1(1), MLL(15), MLL2(15), MLL3(13), MLL4(12), MLL5(5), NSD1(4), OGT(2), PAXIP1(1), PPP1CB(1), PPP1CC(1), PRDM2(5), PRDM7(1), PRDM9(13), PRMT5(1), PRMT6(1), PRMT8(1), RBBP5(2), SATB1(2), SETD1A(8), SETD2(3), SETDB1(3), SETDB2(2), SETMAR(2), SMYD3(1), STK38(1), SUV39H2(1), SUV420H1(3), SUV420H2(1), WHSC1(5), WHSC1L1(3) 16807161 162 61 157 44 96 14 6 24 22 0 0.00295 1.000 1.000 356 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACP1(2), ACTB(3), ACTG1(1), ACTN1(1), ACTN2(4), ACTN4(1), ACVR1B(1), ACVR1C(1), BAIAP2(3), CDC42(2), CDH1(3), CREBBP(4), CSNK2B(1), CTNNA2(3), CTNNA3(4), CTNNB1(6), CTNND1(1), EGFR(4), EP300(1), ERBB2(1), FARP2(4), FER(2), FGFR1(4), FYN(1), IGF1R(4), INSR(6), IQGAP1(2), LEF1(1), LMO7(2), MAPK1(1), MET(8), MLLT4(2), NLK(1), PARD3(4), PTPN6(2), PTPRB(17), PTPRF(7), PTPRJ(2), PTPRM(3), PVRL1(1), PVRL2(1), PVRL4(3), RHOA(1), SMAD2(1), SMAD3(1), SMAD4(2), SNAI2(2), SORBS1(3), SSX2IP(1), TCF7L1(1), TCF7L2(3), TGFBR2(2), TJP1(4), VCL(2), WAS(2), WASF1(2), WASF2(3), WASF3(4), WASL(1), YES1(4) 17062766 164 61 162 82 93 19 7 28 17 0 0.569 1.000 1.000 357 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(2), ACVR1B(1), ACVRL1(3), AKT1(3), AURKB(2), BMPR1A(1), BMPR2(2), BUB1(1), CDKL1(1), CDS1(2), CDS2(2), CLK1(1), CLK2(2), COL4A3BP(2), CSNK2B(1), DGKA(1), DGKB(7), DGKD(2), DGKE(1), DGKG(6), DGKQ(3), DGKZ(2), IMPA1(1), INPP1(1), INPP4A(3), INPP4B(1), INPP5A(1), INPPL1(5), ITPKB(1), MAP3K10(5), MOS(1), NEK1(3), NEK3(1), OCRL(1), PAK4(2), PIK3C2A(2), PIK3C2B(4), PIK3C2G(10), PIK3CA(3), PIK3CB(9), PIK3CG(8), PIM2(1), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PLCG1(6), PLCG2(6), PLK3(1), PRKACA(2), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCA(2), PRKCD(2), PRKCE(2), PRKCG(5), PRKCH(4), PRKCQ(2), PRKD1(1), PRKG1(2), RAF1(3), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), RPS6KA4(2), STK11(2) 15978473 208 61 207 76 129 8 9 41 21 0 0.00826 1.000 1.000 358 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ABP1(2), ACAT2(1), ACMSD(1), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH9A1(1), AOC2(4), AOC3(2), AOX1(5), ASMT(1), CAT(1), CYP19A1(3), CYP1A1(2), CYP1A2(5), CYP2A13(1), CYP2A6(3), CYP2A7(3), CYP2B6(5), CYP2C18(7), CYP2C19(6), CYP2C8(7), CYP2C9(10), CYP2E1(5), CYP2F1(4), CYP2J2(2), CYP3A4(8), CYP3A5(5), CYP3A7(1), CYP4B1(3), CYP4F8(3), DDC(4), ECHS1(1), EHHADH(2), GCDH(3), HAAO(1), HADHA(4), KMO(1), KYNU(5), MAOA(2), MAOB(4), TPH1(2), WARS(1), WARS2(2) 7818913 139 61 137 77 104 11 4 13 7 0 0.216 1.000 1.000 359 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 79 ABL1(6), ATM(6), BUB1(1), BUB1B(5), CCNA1(8), CCNB2(3), CCNB3(8), CCND2(1), CCND3(1), CCNE1(1), CCNE2(5), CDAN1(2), CDC14A(2), CDC25A(1), CDC7(1), CDH1(3), CDKN1A(1), CHEK1(1), CHEK2(1), DTX4(2), E2F2(1), E2F3(4), EP300(1), ESPL1(4), GSK3B(1), HDAC1(1), HDAC2(1), HDAC4(3), HDAC6(1), HDAC8(1), MAD2L2(1), MCM2(2), MCM3(1), MCM4(2), MCM5(1), MCM6(1), MDM2(2), MPEG1(1), MPL(2), ORC1L(1), ORC4L(1), PCNA(2), PLK1(1), PRKDC(6), PTPRA(2), PTTG2(2), RB1(2), RBL1(5), SMAD4(2), TBC1D8(2) 15351643 116 60 116 57 62 8 6 28 11 1 0.633 1.000 1.000 360 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 79 AKT1(3), AKT2(2), AKT3(1), APAF1(1), ATM(6), BIRC3(3), CAPN1(2), CAPN2(2), CASP10(1), CASP3(1), CASP8(4), CHP(1), CHUK(1), CSF2RB(6), DFFA(1), FAS(1), FASLG(4), IKBKB(3), IL1A(1), IL1B(2), IL1R1(2), IL1RAP(1), IL3(2), IL3RA(3), IRAK1(3), IRAK2(2), IRAK3(2), IRAK4(1), NFKB1(1), NFKB2(2), NFKBIA(1), NTRK1(5), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PPP3CA(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP3R2(1), PRKACA(2), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RELA(2), TNFRSF10A(3), TNFSF10(3) 11706844 137 60 135 41 76 10 4 35 11 1 0.00349 1.000 1.000 361 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 65 AGTR1(2), AGTR2(4), ATP8A1(3), AVPR1B(1), AVPR2(1), BDKRB1(2), BDKRB2(2), BRS3(1), C3AR1(1), CCKBR(2), CCR10(1), CCR2(2), CCR3(5), CCR4(4), CCR6(1), CCR7(1), CCR8(2), CX3CR1(5), CXCR3(1), CXCR6(1), EDNRA(4), EDNRB(3), FPR1(3), FSHR(5), GALR1(2), GALR3(1), GALT(1), GHSR(3), GNRHR(1), GPR77(2), GRPR(2), LHCGR(7), MC2R(1), MC3R(1), MC5R(3), NMBR(4), NPY1R(9), NPY2R(3), NPY5R(8), NTSR1(2), NTSR2(1), OPRD1(2), OPRK1(5), OPRL1(3), OPRM1(1), OXTR(1), PPYR1(2), SSTR1(3), SSTR2(1), SSTR3(5), TACR1(3), TACR2(1), TACR3(8), TSHR(5) 7330001 148 60 147 87 98 12 5 21 12 0 0.0130 1.000 1.000 362 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 68 AKT1(3), AKT2(2), AKT3(1), CDC42(2), CHP(1), KDR(8), MAP2K1(3), MAP2K2(2), MAPK1(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPKAPK2(2), NFAT5(2), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), NOS3(6), NRAS(1), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PLA2G2D(2), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), PLCG1(6), PLCG2(6), PPP3CA(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP3R2(1), PRKCA(2), PRKCG(5), PTGS2(2), PTK2(2), PXN(1), RAF1(3), SH2D2A(1), SHC2(2), SPHK1(1), SPHK2(1), VEGFA(2) 10183806 142 58 140 44 79 5 3 39 15 1 0.00415 1.000 1.000 363 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(3), ADCY4(2), ADCY6(2), ADCY8(13), CACNA1A(7), CACNA1B(5), GNAS(5), GNB3(1), GRM4(3), ITPR3(3), KCNB1(10), PDE1A(13), PLCB2(1), PRKACA(2), PRKACB(3), PRKACG(3), PRKX(1), SCNN1A(3), SCNN1B(4), SCNN1G(8), TAS1R1(3), TAS1R2(5), TAS2R1(3), TAS2R10(1), TAS2R14(1), TAS2R16(4), TAS2R3(1), TAS2R38(5), TAS2R39(4), TAS2R4(3), TAS2R40(1), TAS2R41(2), TAS2R42(1), TAS2R43(1), TAS2R46(1), TAS2R5(1), TAS2R60(5), TAS2R7(2), TAS2R8(2), TAS2R9(2), TRPM5(4) 8061639 144 58 144 95 88 12 5 27 12 0 0.409 1.000 1.000 364 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(3), ALG6(1), CCKBR(2), CCR2(2), CCR3(5), CELSR1(7), CELSR2(6), CELSR3(11), CHRM2(3), CHRM3(8), CXCR3(1), EDNRA(4), EMR2(1), EMR3(2), F2R(1), FSHR(5), GHRHR(1), GNRHR(1), GPR116(7), GPR133(1), GPR143(2), GPR18(3), GPR61(2), GPR77(2), GPR84(4), GRM1(4), GRPR(2), HRH4(3), LGR6(5), LPHN2(9), LPHN3(5), LTB4R2(1), NTSR1(2), OR2M4(4), OR8G2(2), P2RY13(2), PTGFR(1), SMO(3), SSTR2(1), TSHR(5) 9474733 134 56 134 90 81 8 9 23 13 0 0.548 1.000 1.000 365 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 53 AKR1D1(7), ARSE(1), CARM1(1), CYP11B1(4), CYP11B2(2), CYP19A1(3), HEMK1(2), HSD11B1(2), HSD17B12(1), HSD17B2(3), HSD3B1(3), HSD3B2(3), LCMT1(2), METTL2B(2), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT8(1), SRD5A1(1), SRD5A2(3), STS(1), SULT1E1(2), SULT2A1(1), SULT2B1(3), UGT1A1(2), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(1), UGT1A8(2), UGT1A9(4), UGT2A1(5), UGT2A3(8), UGT2B10(15), UGT2B11(3), UGT2B28(5), UGT2B4(7), UGT2B7(5), WBSCR22(1) 6832339 119 56 117 53 80 11 6 11 11 0 0.0639 1.000 1.000 366 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 66 ACADM(1), ACOX1(5), ACOX2(1), ACOX3(3), ACSL1(1), ACSL5(5), ACSL6(3), ADIPOQ(1), APOA5(1), AQP7(1), CPT1A(3), CPT1B(4), CPT1C(7), CYP27A1(2), CYP4A11(5), CYP4A22(4), CYP7A1(1), DBI(1), EHHADH(2), FABP1(1), FABP2(3), FADS2(2), GK(1), HMGCS2(5), LPL(1), ME1(8), MMP1(4), NR1H3(2), OLR1(1), PCK1(3), PCK2(1), PDPK1(1), PPARA(3), PPARG(4), RXRG(2), SCD(1), SLC27A2(2), SLC27A4(2), SLC27A5(2), SLC27A6(6), SORBS1(3), UBC(1), UCP1(2) 9180486 112 56 109 55 72 11 5 20 4 0 0.329 1.000 1.000 367 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(1), CLK2(2), CLK3(2), COL2A1(9), CPSF1(2), CPSF2(2), CPSF3(1), CSTF1(1), CSTF2(1), CSTF2T(1), CSTF3(1), DDIT3(1), DDX1(2), DDX20(4), DHX16(2), DHX38(2), DHX8(4), DHX9(4), DICER1(1), DNAJC8(1), LOC440563(4), LSM2(1), NCBP1(1), NONO(5), NXF1(3), POLR2A(4), PRPF18(2), PRPF3(2), PRPF4(1), PRPF4B(2), PRPF8(3), PSKH1(1), PTBP2(3), RBM5(2), RNGTT(1), SF3A1(3), SF3A2(2), SF3A3(1), SF3B1(4), SF3B2(4), SF4(3), SFRS14(5), SFRS5(1), SFRS8(2), SFRS9(1), SNRPB(1), SNRPE(1), SNRPN(2), SPOP(1), SRPK1(3), SRRM1(2), TXNL4A(1), XRN2(2) 15146013 118 56 116 47 61 11 9 19 18 0 0.431 1.000 1.000 368 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(2), ACP2(2), ACP5(2), ACPP(3), ALPI(4), ALPL(1), ALPP(2), ALPPL2(1), CYP19A1(3), CYP1A1(2), CYP1A2(5), CYP2A13(1), CYP2A6(3), CYP2A7(3), CYP2B6(5), CYP2C18(7), CYP2C19(6), CYP2C8(7), CYP2C9(10), CYP2E1(5), CYP2F1(4), CYP2J2(2), CYP3A4(8), CYP3A5(5), CYP3A7(1), CYP4B1(3), CYP4F8(3), PON1(3) 4146393 103 55 101 50 78 9 3 8 5 0 0.0242 1.000 1.000 369 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 46 IMPA1(1), IMPA2(1), INPP1(1), INPP4A(3), INPP4B(1), INPP5A(1), INPP5B(1), INPPL1(5), ITPK1(1), ITPKB(1), MINPP1(1), OCRL(1), PI4KA(2), PI4KB(1), PIK3C3(1), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIP4K2A(3), PIP4K2B(1), PIP4K2C(3), PIP5K1A(1), PIP5K1B(4), PIP5K1C(2), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PLCD4(2), PLCE1(10), PLCG1(6), PLCG2(6), PLCZ1(5), SYNJ1(7), SYNJ2(2) 10381442 135 54 134 53 79 6 7 31 12 0 0.0392 1.000 1.000 370 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 CPEB1(2), EGFR(4), ERBB2(1), ERBB4(15), ETS1(1), ETS2(2), ETV6(3), ETV7(2), FMN2(16), GRB2(1), MAP2K1(3), MAPK1(1), NOTCH1(1), NOTCH2(10), NOTCH3(6), NOTCH4(14), PIWIL1(3), PIWIL2(3), PIWIL3(2), PIWIL4(1), RAF1(3), SOS1(3), SOS2(4), SPIRE1(1), SPIRE2(1) 7236391 103 54 100 46 61 5 4 24 9 0 0.506 1.000 1.000 371 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(4), CALR(1), CD4(5), CD8A(1), CIITA(5), CTSL1(1), CTSS(1), HLA-B(1), HLA-DMB(4), HLA-DOB(1), HLA-DPA1(1), HLA-DQA1(2), HLA-DQA2(2), HLA-DRA(3), HLA-DRB1(1), HLA-F(1), HLA-G(1), HSP90AA1(1), HSP90AB1(3), HSPA5(2), IFI30(1), IFNA1(1), IFNA16(3), IFNA21(3), IFNA5(2), IFNA6(1), IFNA7(2), KIR2DL1(5), KIR2DL3(2), KIR2DL4(1), KIR2DS4(2), KIR3DL1(4), KIR3DL3(2), KLRC1(2), KLRC3(4), KLRC4(2), KLRD1(1), LGMN(2), NFYB(2), NFYC(1), PDIA3(2), RFX5(1), RFXANK(1), RFXAP(1), TAP2(5) 6519683 94 54 94 46 50 8 5 19 12 0 0.358 1.000 1.000 372 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 82 ATF2(2), CHUK(1), DAXX(1), ELK1(1), FOS(1), GRB2(1), IKBKB(3), JUN(1), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(1), MAP2K6(1), MAP2K7(1), MAP3K1(1), MAP3K10(5), MAP3K11(1), MAP3K12(1), MAP3K13(4), MAP3K2(3), MAP3K3(2), MAP3K4(5), MAP3K5(5), MAP3K9(5), MAP4K1(3), MAP4K2(2), MAP4K3(2), MAP4K4(1), MAP4K5(2), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK4(5), MAPK6(2), MAPK7(1), MAPK9(1), MAPKAPK2(2), MAPKAPK5(1), MEF2A(1), MEF2D(1), MKNK1(2), NFKB1(1), NFKBIA(1), PAK1(2), PAK2(5), RAF1(3), RELA(2), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), RPS6KA4(2), RPS6KA5(1), TGFB3(2) 13167371 115 54 113 70 55 12 7 27 14 0 0.952 1.000 1.000 373 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 AGT(3), AKT1(3), CALM2(1), CALR(1), CAMK1(2), CAMK1G(1), CAMK4(2), CREBBP(4), CSNK1A1(1), EDN1(3), ELSPBP1(2), F2(2), GSK3B(1), HAND1(1), HAND2(1), IGF1(5), MAP2K1(3), MAPK1(1), MAPK14(2), MYH2(17), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), NPPA(1), PIK3CA(3), PIK3R1(3), PPP3CA(4), PPP3CB(3), PPP3CC(1), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RAF1(3), SYT1(8) 7224845 104 53 100 40 66 6 4 18 9 1 0.0684 1.000 1.000 374 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(3), AKT2(2), AKT3(1), BCR(2), BLNK(2), BTK(5), CD19(4), CD22(5), CR2(8), CSK(1), DAG1(1), FLOT1(1), GRB2(1), GSK3B(1), INPP5D(6), ITPR1(10), ITPR2(3), ITPR3(3), LYN(2), MAP4K1(3), MAPK1(1), NFATC1(5), NFATC2(2), NR0B2(1), PIK3CA(3), PIK3CD(3), PIK3R1(3), PLCG2(6), PPP1R13B(3), PPP3CA(4), PPP3CB(3), PPP3CC(1), PTPRC(16), RAF1(3), SOS1(3), SOS2(4), SYK(5), VAV1(5) 10503895 135 53 134 41 84 5 11 21 13 1 0.000659 1.000 1.000 375 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(3), AKT2(2), AKT3(1), BCR(2), BTK(5), CD19(4), DAPP1(1), FLOT1(1), ITPR1(10), ITPR2(3), ITPR3(3), LYN(2), NR0B2(1), PIK3CA(3), PITX2(1), PLCG2(6), PPP1R13B(3), PREX1(4), PTPRC(16), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), SAG(3), SYK(5), TEC(4), VAV1(5) 7632318 95 53 92 39 60 4 8 15 8 0 0.0399 1.000 1.000 376 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 61 AKT1(3), AKT2(2), AKT3(1), CDC42(2), CREB5(2), ERBB4(15), F2RL2(2), GRB2(1), GSK3B(1), IGF1(5), IGFBP1(1), INPPL1(5), IRS1(1), IRS4(3), MET(8), NOLC1(1), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PAK7(10), PARD3(4), PIK3CA(3), PIK3CD(3), PPP1R13B(3), PREX1(4), PTK2(2), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), SLC2A4(3), SOS1(3), SOS2(4), TSC1(1), TSC2(3), YWHAB(1), YWHAQ(1) 10797560 118 53 117 59 62 9 8 31 8 0 0.604 1.000 1.000 377 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(3), CABIN1(3), CALM2(1), CAMK2B(2), CAMK4(2), CD69(2), CDKN1A(1), CNR1(1), CREBBP(4), CSNK2B(1), EGR2(2), EP300(1), FCER1A(4), FCGR3A(1), FOS(1), GRLF1(2), GSK3B(1), ICOS(1), IFNA1(1), IFNB1(2), IFNG(1), IL10(1), IL1B(2), IL2RA(1), IL3(2), ITK(2), KPNA5(1), MAP2K7(1), MAPK14(2), MAPK9(1), MEF2A(1), MEF2D(1), MYF5(4), NCK2(2), NFAT5(2), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), NFKB2(2), NUP214(4), OPRD1(2), P2RX7(1), PAK1(2), PIN1(1), PPP3CB(3), PPP3CC(1), PPP3R1(1), PTPRC(16), RELA(2), TRPV6(7), VAV1(5), VAV3(1) 12951056 120 52 116 53 73 4 8 24 11 0 0.231 1.000 1.000 378 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACSS2(1), ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH5(1), ADH6(3), ADH7(5), AKR1A1(1), ALDH1B1(2), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), ALDH7A1(3), ALDH9A1(1), ALDOB(2), ALDOC(2), DLAT(1), ENO1(1), ENO2(1), ENO3(1), FBP1(1), FBP2(1), G6PC2(2), GCK(5), GPI(1), HK1(2), HK2(4), HK3(3), LDHA(1), LDHAL6A(4), LDHAL6B(1), LDHB(2), LDHC(2), PDHA1(1), PDHA2(6), PFKL(2), PFKM(1), PGAM2(1), PGK1(3), PGK2(10), PGM1(3), PKLR(2), PKM2(1) 8275988 108 52 105 42 72 10 5 15 6 0 0.0105 1.000 1.000 379 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(3), CAD(4), CANT1(1), DPYD(17), DPYS(12), ENTPD1(2), ENTPD3(2), ENTPD4(1), ENTPD6(1), ENTPD8(1), NME7(1), NT5C1A(1), NT5C1B(6), NT5C2(2), NT5E(1), POLA1(1), POLA2(2), POLD1(2), POLD3(1), POLE(4), POLE2(1), POLR1A(2), POLR1B(1), POLR2A(4), POLR2B(4), POLR2C(1), POLR2D(1), POLR2H(2), POLR3B(7), POLR3H(1), PRIM1(2), PRIM2(5), RRM1(1), RRM2(2), RRM2B(2), TK2(1), TXNRD1(1), TYMS(1), UPB1(2), UPP2(1), UPRT(1) 11538138 108 52 105 62 62 12 9 16 9 0 0.748 1.000 1.000 380 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), ABP1(2), ACAT2(1), ACMSD(1), AFMID(1), ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1), AOC2(4), AOC3(2), AOX1(5), ASMT(1), CARM1(1), CAT(1), CYP1A1(2), CYP1A2(5), CYP1B1(1), DDC(4), ECHS1(1), EHHADH(2), GCDH(3), HAAO(1), HADHA(4), HEMK1(2), HSD17B10(2), HSD17B4(4), INMT(2), KMO(1), KYNU(5), LCMT1(2), LNX1(3), MAOA(2), MAOB(4), METTL2B(2), METTL6(1), NFX1(3), OGDH(4), OGDHL(10), PRMT2(2), PRMT5(1), PRMT6(1), PRMT8(1), TPH1(2), TPH2(1), WARS(1), WARS2(2), WBSCR22(1) 8610665 109 52 108 60 67 8 8 19 7 0 0.560 1.000 1.000 381 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP5(4), BMP6(3), BMP8A(1), BMP8B(1), CSNK1A1(1), CSNK1A1L(1), CSNK1E(1), CSNK1G1(2), CSNK1G2(1), CSNK1G3(2), FBXW11(1), GLI1(6), GLI2(8), GLI3(7), GSK3B(1), HHIP(6), LRP2(14), PRKACA(2), PRKACB(3), PRKACG(3), PRKX(1), PTCH1(3), PTCH2(5), SHH(2), SMO(3), STK36(5), SUFU(1), WNT1(1), WNT10A(1), WNT10B(2), WNT11(1), WNT2(1), WNT2B(3), WNT3(2), WNT5B(2), WNT7A(5), WNT7B(1), WNT8A(3), WNT8B(1), WNT9A(2), WNT9B(1), ZIC2(1) 8563703 116 52 112 51 76 8 4 14 14 0 0.0897 1.000 1.000 382 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT1(3), AKT2(2), AKT3(1), DAG1(1), DRD2(7), EGFR(4), EPHB2(8), GRB2(1), ITPKB(1), ITPR1(10), ITPR2(3), ITPR3(3), KCNJ3(5), KCNJ5(3), KCNJ9(1), MAPK1(1), PI3(1), PIK3CB(9), PITX2(1), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), RAF1(3), SOS1(3), SOS2(4), STAT3(6) 8101587 119 52 117 46 67 10 9 23 10 0 0.0256 1.000 1.000 383 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(3), AGT(3), AGTR1(2), AGTR2(4), CMA1(1), COL4A1(14), COL4A2(8), COL4A3(13), COL4A4(22), COL4A5(20), COL4A6(6), REN(3) 3602325 99 51 97 25 79 5 2 8 5 0 0.260 1.000 1.000 384 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACADM(1), ACADSB(2), ACAT2(1), ACOX1(5), ACOX3(3), ACSL1(1), ACSL5(5), ACSL6(3), ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH5(1), ADH6(3), ADH7(5), ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1), CPT1A(3), CPT1B(4), CPT1C(7), CYP4A11(5), CYP4A22(4), DCI(1), ECHS1(1), EHHADH(2), GCDH(3), HADHA(4), HSD17B10(2), HSD17B4(4), PECI(1) 7007664 97 51 95 41 61 12 7 11 6 0 0.121 1.000 1.000 385 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(2), ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH5(1), ADH6(3), ADH7(5), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), AOC2(4), AOC3(2), AOX1(5), CARM1(1), COMT(1), DBH(5), DCT(1), DDC(4), ESCO1(1), GOT1(3), GOT2(1), HEMK1(2), HGD(4), HPD(2), LCMT1(2), MAOA(2), MAOB(4), METTL2B(2), METTL6(1), MYST3(3), MYST4(2), PNPLA3(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT8(1), SH3GLB1(1), TAT(4), TH(4), TPO(12), TYR(4), TYRP1(3), WBSCR22(1) 8467716 121 51 119 72 81 12 7 16 5 0 0.709 1.000 1.000 386 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH5(1), ADH6(3), ADH7(5), AGK(1), AGPAT3(4), AGPAT4(1), AGPAT6(1), AKR1A1(1), AKR1B1(1), ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1), CEL(5), DGAT2(1), DGKA(1), DGKB(7), DGKD(2), DGKE(1), DGKG(6), DGKI(11), DGKQ(3), DGKZ(2), GK(1), GLB1(2), GPAM(1), LCT(6), LIPC(3), LIPF(5), LIPG(2), LPL(1), MGLL(1), PNLIP(1), PNLIPRP1(2), PNPLA3(1), PPAP2C(1) 8222732 110 51 106 51 69 13 5 16 7 0 0.129 1.000 1.000 387 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(1), CREBBP(4), CTBP2(1), DLL3(2), DLL4(2), DTX1(3), DTX3(1), DTX3L(3), DTX4(2), DVL3(4), EP300(1), HDAC1(1), HDAC2(1), HES1(2), JAG1(2), JAG2(5), MAML1(1), MAML3(1), MFNG(2), NCOR2(8), NOTCH1(1), NOTCH2(10), NOTCH3(6), NOTCH4(14), NUMB(2), PSEN1(1), PSEN2(2), PTCRA(3), RBPJ(1), RBPJL(1), SNW1(1) 9746299 89 51 89 44 50 7 4 21 7 0 0.618 1.000 1.000 388 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(3), ACSL1(1), ACSL5(5), ACSL6(3), ADIPOQ(1), AGRP(1), AKT1(3), AKT2(2), AKT3(1), CHUK(1), CPT1A(3), CPT1B(4), CPT1C(7), G6PC2(2), IKBKB(3), IRS1(1), IRS4(3), JAK1(2), JAK2(2), JAK3(1), LEP(1), LEPR(4), MAPK10(2), MAPK9(1), NFKB1(1), NFKB2(2), NFKBIA(1), NPY(3), PCK1(3), PCK2(1), PPARA(3), PPARGC1A(2), PRKAA2(6), PRKAB1(1), PRKAG1(1), PRKAG2(3), PRKAG3(2), PRKCQ(2), PTPN11(2), RELA(2), RXRG(2), SLC2A1(3), SLC2A4(3), SOCS3(1), STAT3(6), STK11(2), TYK2(1) 11804714 110 51 110 64 52 13 8 22 15 0 0.832 1.000 1.000 389 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 AKT1(3), BDKRB2(2), CALM2(1), CHRNA1(1), FLT1(8), FLT4(3), KDR(8), NOS3(6), PDE2A(3), PDE3A(3), PDE3B(3), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKG1(2), PRKG2(4), RYR2(30), SLC7A1(1), SYT1(8) 5809471 96 51 91 42 69 4 3 9 11 0 0.0652 1.000 1.000 390 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(6), AXIN1(3), CCND2(1), CCND3(1), CSNK1E(1), CTNNB1(6), DVL3(4), FZD1(2), FZD2(2), FZD8(3), FZD9(1), GSK3B(1), JUN(1), LDLR(3), MAPK10(2), MAPK9(1), PAFAH1B1(2), PLAU(1), PPP2R5E(1), PRKCA(2), PRKCD(2), PRKCE(2), PRKCG(5), PRKCH(4), PRKCI(3), PRKCQ(2), PRKD1(1), RHOA(1), SFRP4(3), WNT1(1), WNT10A(1), WNT10B(2), WNT11(1), WNT2(1), WNT2B(3), WNT3(2), WNT5B(2), WNT7A(5), WNT7B(1) 8408026 86 50 85 33 49 10 2 9 16 0 0.0355 1.000 1.000 391 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 60 APAF1(1), ATM(6), ATR(6), BAI1(4), CASP3(1), CASP8(4), CCNB2(3), CCNB3(8), CCND2(1), CCND3(1), CCNE1(1), CCNE2(5), CDK6(1), CDKN1A(1), CHEK1(1), CHEK2(1), DDB2(1), FAS(1), GTSE1(1), IGF1(5), LRDD(2), MDM2(2), MDM4(1), PERP(1), RFWD2(1), RPRM(1), RRM2(2), RRM2B(2), SERPINB5(1), SERPINE1(1), SESN2(1), STEAP3(1), THBS1(8), TP53I3(2), TP73(1), TSC2(3) 8839808 83 49 83 49 43 5 6 24 5 0 0.923 1.000 1.000 392 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM10(4), ADAM17(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(4), ATP6V0D2(1), ATP6V0E1(1), ATP6V1B1(3), ATP6V1C2(2), ATP6V1G3(1), CASP3(1), CDC42(2), CHUK(1), CSK(1), EGFR(4), F11R(3), HBEGF(1), IGSF5(3), IKBKB(3), JAM2(4), JAM3(2), JUN(1), LYN(2), MAP2K4(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK9(1), MET(8), NFKB1(1), NFKB2(2), NFKBIA(1), NOD1(1), PAK1(2), PLCG1(6), PLCG2(6), PTPN11(2), PTPRZ1(5), RELA(2), TCIRG1(2), TJP1(4) 9965506 101 49 101 52 51 13 6 25 6 0 0.603 1.000 1.000 393 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(1), DLG4(1), GRIN2A(27), GRIN2B(16), GRIN2C(2), GRIN2D(1), NOS1(17), PPP3CA(4), PPP3CB(3), PPP3CC(1), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCA(2), SYT1(8) 3622923 93 49 91 35 69 8 1 7 8 0 0.00337 1.000 1.000 394 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(16), B3GALT4(2), DGKI(11), IL6ST(5), MRPL19(1), PIGK(1), RPL10(1), RPL11(1), RPL15(1), RPL18(1), RPL21(1), RPL22(1), RPL27(2), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL38(1), RPL3L(1), RPL4(1), RPL5(3), RPS11(1), RPS16(1), RPS23(1), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), RPS6KA6(7), RPS7(3), RPS8(1), SLC36A2(3), TBC1D10C(1), TSPAN9(2), UBC(1) 7324041 83 49 80 43 45 5 8 16 9 0 0.535 1.000 1.000 395 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 ALG2(2), BTK(5), CAD(4), CASP10(1), CASP3(1), CASP8(4), CASP8AP2(3), CSNK1A1(1), DAXX(1), DEDD(1), DFFA(1), EGFR(4), EPHB2(8), FAF1(4), FAIM2(2), HSPB1(1), IL1A(1), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K5(5), MAPK1(1), MAPK10(2), MAPK8IP1(1), MAPK8IP2(1), MAPK9(1), MET(8), NFAT5(2), NFKB1(1), NFKB2(2), NFKBIA(1), NFKBIL1(2), NFKBIL2(2), NR0B2(1), PTPN13(4), ROCK1(2), SMPD1(2), TNFRSF6B(2), TPX2(2), TUFM(1) 10232668 90 49 89 44 44 11 8 16 11 0 0.528 1.000 1.000 396 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 22 AKT1(3), APC(6), DAG1(1), DLG4(1), EPHB2(8), GNAI1(1), GNAQ(1), ITPR1(10), ITPR2(3), ITPR3(3), KCNJ3(5), KCNJ5(3), KCNJ9(1), MAPK1(1), PITX2(1), PTX3(1), RYR1(27) 6410291 76 49 76 41 56 7 4 2 7 0 0.183 1.000 1.000 397 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(1), CSK(1), DAG1(1), EPHB2(8), FBXW7(4), GRAP2(1), GRB2(1), ITK(2), ITPKB(1), LAT(1), LCK(1), LCP2(4), MAPK1(1), NFAT5(2), NFKB1(1), NFKB2(2), NFKBIA(1), NFKBIL1(2), NFKBIL2(2), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PAK7(10), PLCG1(6), PTPRC(16), RAF1(3), RASGRP2(3), RASGRP3(3), RASGRP4(4), SOS1(3), SOS2(4), VAV1(5) 7894086 107 49 106 42 64 8 10 19 6 0 0.0888 1.000 1.000 398 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 62 ATM(6), CCNA1(8), CCND2(1), CCND3(1), CCNE1(1), CCNE2(5), CDC25A(1), CDKN1A(1), CREB3L3(3), CREB3L4(3), E2F2(1), E2F3(4), GBA2(1), MCM2(2), MCM3(1), MCM4(2), MCM5(1), MCM6(1), MDM2(2), MNAT1(2), MYT1(7), ORC1L(1), ORC4L(1), PCNA(2), POLA2(2), POLE(4), POLE2(1), PRIM1(2), RB1(2), RBL1(5), RPA1(2), RPA2(1), RPA3(1), TFDP2(2), TNXB(42) 10972956 122 48 121 51 65 9 3 34 10 1 0.235 1.000 1.000 399 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 40 ALAD(1), ALAS1(1), ALAS2(3), COX15(1), CP(3), EPRS(5), FTMT(2), GUSB(3), HCCS(2), HMOX1(1), UGT1A1(2), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(1), UGT1A8(2), UGT1A9(4), UGT2A1(5), UGT2A3(8), UGT2B10(15), UGT2B11(3), UGT2B28(5), UGT2B4(7), UGT2B7(5) 5724982 87 48 86 36 57 7 3 10 10 0 0.144 1.000 1.000 400 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 43 AKT1(3), AKT2(2), AKT3(1), FIGF(2), HIF1A(3), IGF1(5), MAPK1(1), PDPK1(1), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PRKAA2(6), RICTOR(2), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), RPS6KA6(7), STK11(2), TSC1(1), TSC2(3), ULK1(1), ULK2(3), ULK3(1), VEGFA(2), VEGFB(1), VEGFC(6) 7279293 96 48 95 33 49 3 4 28 11 1 0.0703 1.000 1.000 401 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP1(1), INPP4A(3), INPP4B(1), INPP5A(1), INPPL1(5), ITPKB(1), OCRL(1), PIK3C2A(2), PIK3C2B(4), PIK3C2G(10), PIK3CA(3), PIK3CB(9), PIK3CG(8), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PLCG1(6), PLCG2(6) 6357232 100 47 99 36 61 4 6 21 8 0 0.0306 1.000 1.000 402 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 43 AKT1(3), AKT2(2), AKT3(1), ANGPTL2(1), ARHGEF11(4), BTK(5), CDC42(2), CFL1(1), GDI2(1), INPPL1(5), ITPR1(10), ITPR2(3), ITPR3(3), MYLK(9), MYLK2(2), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PAK7(10), PIK3CA(3), PIK3CD(3), PIK3CG(8), PIK3R1(3), PITX2(1), PPP1R13B(3), ROCK1(2), ROCK2(6), SAG(3), WASF1(2), WASL(1) 9824477 110 47 109 42 67 10 4 21 7 1 0.0250 1.000 1.000 403 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(2), ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH6(3), ADH7(5), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), AOC2(4), AOC3(2), AOX1(5), COMT(1), DBH(5), DCT(1), DDC(4), GOT1(3), GOT2(1), HGD(4), HPD(2), MAOA(2), MAOB(4), TAT(4), TH(4), TPO(12), TYR(4) 4506438 95 47 93 52 71 8 4 9 3 0 0.270 1.000 1.000 404 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH6(3), ADH7(5), AKR1A1(1), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), ALDH9A1(1), ALDOB(2), ALDOC(2), DLAT(1), ENO1(1), ENO2(1), ENO3(1), FBP1(1), FBP2(1), GCK(5), GPI(1), HK1(2), HK2(4), HK3(3), LDHA(1), LDHB(2), LDHC(2), PDHA1(1), PDHA2(6), PFKM(1), PGK1(3), PGM1(3), PKLR(2), PKM2(1) 6949287 85 46 83 34 55 10 4 11 5 0 0.0267 1.000 1.000 405 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH6(3), ADH7(5), AKR1A1(1), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), ALDH9A1(1), ALDOB(2), ALDOC(2), DLAT(1), ENO1(1), ENO2(1), ENO3(1), FBP1(1), FBP2(1), GCK(5), GPI(1), HK1(2), HK2(4), HK3(3), LDHA(1), LDHB(2), LDHC(2), PDHA1(1), PDHA2(6), PFKM(1), PGK1(3), PGM1(3), PKLR(2), PKM2(1) 6949287 85 46 83 34 55 10 4 11 5 0 0.0267 1.000 1.000 406 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(1), AKT1(3), ANGPTL2(1), CDC42(2), CFL1(1), FLNA(6), FLNC(15), FSCN1(1), FSCN3(3), GDI2(1), MYH2(17), MYLK(9), MYLK2(2), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PAK7(10), ROCK1(2), ROCK2(6), VASP(1), WASF1(2), WASL(1) 6781914 97 46 97 53 59 9 3 19 7 0 0.414 1.000 1.000 407 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CALM2(1), CAMK1(2), CAMK1G(1), ELK1(1), FPR1(3), GNA15(3), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K6(1), MAP3K1(1), MAPK1(1), MAPK14(2), NCF2(2), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), NFKB1(1), NFKBIA(1), PAK1(2), PIK3C2G(10), PLCB1(16), PPP3CA(4), PPP3CB(3), PPP3CC(1), RAF1(3), RELA(2), SYT1(8) 5367798 90 45 87 30 59 5 5 13 8 0 0.0251 1.000 1.000 408 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 24 AKR1B1(1), GUSB(3), UGDH(1), UGT1A1(2), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(1), UGT1A8(2), UGT1A9(4), UGT2A1(5), UGT2A3(8), UGT2B10(15), UGT2B11(3), UGT2B28(5), UGT2B4(7), UGT2B7(5), XYLB(4) 3602005 74 45 73 31 54 4 3 7 6 0 0.133 1.000 1.000 409 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(2), ALOX12(2), ALOX12B(4), ALOX15B(2), CYP2B6(5), CYP2C18(7), CYP2C19(6), CYP2C8(7), CYP2C9(10), CYP2E1(5), CYP2J2(2), CYP4A11(5), CYP4A22(4), CYP4F2(6), CYP4F3(4), EPHX2(1), GGT1(2), GPX1(1), GPX5(2), GPX6(3), LTA4H(2), PLA2G2D(2), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), PTGIS(2), PTGS1(7), PTGS2(2), TBXAS1(3) 5497896 107 45 106 60 82 7 2 9 7 0 0.138 1.000 1.000 410 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(6), CCND2(1), DAZL(3), DMC1(2), ESR2(3), FSHR(5), INHA(1), LHCGR(7), MLH1(1), MSH5(4), NCOR1(7), NR5A1(1), NRIP1(2), PGR(4), PRLR(9), PTGER2(2), SMPD1(2), VDR(1), ZP2(4) 4886350 65 45 63 31 41 7 1 7 9 0 0.472 1.000 1.000 411 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(4), CANT1(1), DPYD(17), DPYS(12), ENTPD1(2), NT5E(1), POLD1(2), POLE(4), POLG(4), POLL(1), POLQ(7), POLR1B(1), POLR2A(4), POLR2B(4), POLR2C(1), POLR2D(1), POLR2H(2), POLRMT(1), RRM1(1), RRM2(2), TK2(1), TXNRD1(1), TYMS(1), UPB1(2) 8162541 77 45 74 34 47 4 6 13 7 0 0.259 1.000 1.000 412 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH6(3), ADH7(5), AGPAT3(4), AGPAT4(1), AKR1A1(1), AKR1B1(1), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH9A1(1), CEL(5), DGKA(1), DGKB(7), DGKD(2), DGKE(1), DGKG(6), DGKQ(3), DGKZ(2), GK(1), GLB1(2), LCT(6), LIPC(3), LIPF(5), LIPG(2), LPL(1), PNLIP(1), PNLIPRP1(2), PPAP2C(1) 6876910 92 44 90 43 61 13 4 12 2 0 0.139 1.000 1.000 413 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(1), AKR1B10(3), B4GALT1(1), B4GALT2(1), G6PC2(2), GAA(1), GALK2(1), GALT(1), GANC(4), GCK(5), GLB1(2), HK1(2), HK2(4), HK3(3), HSD3B7(2), LALBA(2), LCT(6), MGAM(39), PFKL(2), PFKM(1), PGM1(3), RDH11(1), RDH12(1), RDH13(1) 5487034 89 44 89 53 61 3 3 15 7 0 0.547 1.000 1.000 414 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ABP1(2), ACADM(1), ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1), AOC2(4), AOC3(2), CNDP1(3), DPYD(17), DPYS(12), ECHS1(1), EHHADH(2), GAD1(5), GAD2(4), HADHA(4), SMS(4), UPB1(2) 3852227 71 44 69 31 38 10 4 13 6 0 0.222 1.000 1.000 415 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(6), ACTB(3), ACTG1(1), ARHGEF2(6), CD14(1), CDC42(2), CDH1(3), CLDN1(3), CTNNB1(6), FYN(1), HCLS1(1), ITGB1(1), LY96(3), NCK2(2), NCL(3), PRKCA(2), RHOA(1), ROCK1(2), ROCK2(6), TLR4(6), TLR5(3), TUBA1C(1), TUBA3C(3), TUBA3D(2), TUBA4A(1), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(1), TUBB3(1), TUBB4(2), TUBB4Q(3), TUBB6(2), TUBB8(1), WAS(2), WASL(1), YWHAQ(1) 7457780 87 44 87 34 49 13 1 11 13 0 0.0715 1.000 1.000 416 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(6), ACTB(3), ACTG1(1), ARHGEF2(6), CD14(1), CDC42(2), CDH1(3), CLDN1(3), CTNNB1(6), FYN(1), HCLS1(1), ITGB1(1), LY96(3), NCK2(2), NCL(3), PRKCA(2), RHOA(1), ROCK1(2), ROCK2(6), TLR4(6), TLR5(3), TUBA1C(1), TUBA3C(3), TUBA3D(2), TUBA4A(1), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(1), TUBB3(1), TUBB4(2), TUBB4Q(3), TUBB6(2), TUBB8(1), WAS(2), WASL(1), YWHAQ(1) 7457780 87 44 87 34 49 13 1 11 13 0 0.0715 1.000 1.000 417 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(2), AGMAT(1), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH9A1(1), AOC2(4), AOC3(2), ARG1(1), ASL(2), CKM(1), CKMT2(2), CPS1(5), DAO(3), GAMT(1), GATM(2), GOT1(3), GOT2(1), MAOA(2), MAOB(4), NOS1(17), NOS3(6), ODC1(3), OTC(1), P4HA1(3), P4HA2(2), P4HA3(5), P4HB(1), RARS(1), SMS(4) 6281146 86 43 85 37 55 8 7 8 8 0 0.0524 1.000 1.000 418 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ABP1(2), ACADM(1), ACADSB(2), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH9A1(1), AOC2(4), AOC3(2), CNDP1(3), DPYD(17), DPYS(12), ECHS1(1), EHHADH(2), GAD1(5), GAD2(4), HADHA(4), SMS(4), UPB1(2) 4144329 73 43 71 32 39 11 3 14 6 0 0.239 1.000 1.000 419 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(1), B4GALT1(1), B4GALT2(1), FBP2(1), GAA(1), GALK2(1), GALT(1), GANAB(2), GCK(5), GLB1(2), HK1(2), HK2(4), HK3(3), LALBA(2), LCT(6), MGAM(39), PFKM(1), PGM1(3) 4629163 76 43 76 46 52 3 3 12 6 0 0.578 1.000 1.000 420 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(11), GABBR1(1), GPRC5A(1), GPRC5B(2), GPRC5C(4), GPRC5D(2), GRM1(4), GRM2(1), GRM3(11), GRM4(3), GRM5(3), GRM7(6), GRM8(17) 2978506 66 43 65 43 50 6 3 6 1 0 0.234 1.000 1.000 421 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AASDHPPT(3), AASS(2), ACAT2(1), AKR1B10(3), ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1), BBOX1(1), DOT1L(3), ECHS1(1), EHHADH(2), EHMT1(1), EHMT2(5), GCDH(3), HADHA(4), HSD17B10(2), HSD17B4(4), HSD3B7(2), NSD1(4), OGDH(4), OGDHL(10), PIPOX(2), PLOD1(2), PLOD2(1), PLOD3(2), RDH11(1), RDH12(1), RDH13(1), SETD1A(8), SETDB1(3), SHMT1(1), SUV39H2(1) 8228095 86 43 85 35 49 7 6 18 6 0 0.156 1.000 1.000 422 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(3), ATF2(2), CDC42(2), DUSP8(2), GCK(5), IL1R1(2), JUN(1), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K10(5), MAP3K11(1), MAP3K12(1), MAP3K13(4), MAP3K2(3), MAP3K3(2), MAP3K4(5), MAP3K5(5), MAP3K9(5), MAPK10(2), MAPK7(1), MAPK9(1), MYEF2(3), NFATC3(4), PAPPA(9), TRAF6(1) 7047232 72 43 72 41 44 5 3 10 10 0 0.890 1.000 1.000 423 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(3), CYP1A2(5), CYP2C18(7), CYP2C19(6), CYP2C8(7), CYP2C9(10), CYP2E1(5), CYP2J2(2), CYP3A4(8), CYP3A43(7), CYP3A5(5), CYP3A7(1), HSD3B7(2), PLA2G2D(2), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), RDH11(1), RDH12(1), RDH13(1) 3402576 82 42 80 36 63 6 2 5 6 0 0.0243 1.000 1.000 424 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 47 AKT1(3), AKT2(2), AKT3(1), BRD4(5), CBL(1), CDC42(2), F2RL2(2), FLOT1(1), GRB2(1), GSK3B(1), IGFBP1(1), INPPL1(5), IRS1(1), IRS4(3), LNPEP(5), MAPK1(1), PARD3(4), PIK3CA(3), PIK3CD(3), PIK3R1(3), PPYR1(2), RAF1(3), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), SLC2A4(3), SORBS1(3), SOS1(3), SOS2(4), YWHAB(1), YWHAQ(1) 8298482 75 42 75 31 33 10 6 20 5 1 0.362 1.000 1.000 425 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(3), F11(3), F13B(7), F2(2), F5(9), F7(1), F8(19), F9(2), FGA(8), FGB(5), FGG(3), LPA(10), PLAU(1), PLG(4), SERPINB2(4), SERPINE1(1), VWF(11) 5009419 93 41 93 37 64 6 4 11 7 1 0.151 1.000 1.000 426 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(2), ACY3(1), ALDH1B1(2), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), ALDH7A1(3), ALDH9A1(1), AMDHD1(3), AOC2(4), AOC3(2), CARM1(1), CNDP1(3), DDC(4), FTCD(1), HAL(6), HARS(2), HARS2(2), HDC(6), HEMK1(2), LCMT1(2), MAOA(2), MAOB(4), METTL2B(2), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT8(1), PRPS1(2), PRPS2(1), UROC1(2), WBSCR22(1) 5628574 71 41 71 45 43 8 4 9 7 0 0.673 1.000 1.000 427 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(4), ALPL(1), ALPP(2), ALPPL2(1), ASCC3(2), ATP13A2(3), DDX18(2), DDX23(3), DDX4(2), DDX41(3), DDX51(2), DDX52(1), DDX54(1), DDX55(1), DHX58(3), ENTPD7(1), EP400(7), ERCC2(1), ERCC3(1), IFIH1(7), MOV10L1(7), NUDT5(1), RAD54B(2), RUVBL2(2), SETX(7), SKIV2L2(2), SMARCA2(2), SMARCA5(4), SPR(1) 8895297 76 41 72 31 39 8 5 15 9 0 0.237 1.000 1.000 428 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(9), C5(4), C6(21), C7(11), IL1A(1), ITGA4(10), ITGAL(6), ITGB1(1), ITGB2(2), SELP(11), SELPLG(3), VCAM1(3) 3524836 82 41 79 30 58 4 3 11 6 0 0.0280 1.000 1.000 429 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(5), CPT1B(4), CREBBP(4), EHHADH(2), EP300(1), FABP1(1), HSD17B4(4), JUN(1), LPL(1), MAPK1(1), ME1(8), NCOA1(3), NCOR1(7), NCOR2(8), NFKBIA(1), NR0B2(1), NR1H3(2), NR2F1(1), NRIP1(2), PDGFA(1), PIK3CA(3), PIK3R1(3), PPARA(3), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCA(2), PTGS2(2), RB1(2), RELA(2), STAT5A(1), STAT5B(1) 9029133 87 41 86 35 50 4 7 17 7 2 0.256 1.000 1.000 430 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 AKT1(3), APC(6), DAG1(1), EGFR(4), GNA15(3), GNAI1(1), GNAQ(1), ITPKB(1), ITPR1(10), ITPR2(3), ITPR3(3), KCNJ3(5), KCNJ5(3), KCNJ9(1), MAPK1(1), MAPK10(2), MAPK14(2), PHKA2(3), PIK3CA(3), PIK3CD(3), PIK3R1(3), PITX2(1), PTX3(1), RAF1(3) 7340732 67 41 67 35 33 9 5 9 10 1 0.482 1.000 1.000 431 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(3), AKT2(2), AKT3(1), ANKRD6(1), APC(6), AXIN1(3), AXIN2(1), CER1(5), CSNK1A1(1), CTNNB1(6), DACT1(3), DKK1(1), DKK2(2), DKK4(1), GSK3B(1), LRP1(7), MVP(5), NKD1(3), NKD2(3), PIN1(1), PSEN1(1), PTPRA(2), SENP2(3), TSHB(1) 5685907 63 41 62 30 32 7 3 10 11 0 0.462 1.000 1.000 432 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 AGPAT3(4), AGPAT4(1), AGPAT6(1), CDS1(2), CDS2(2), CHAT(3), CHKA(1), CHKB(1), CRLS1(1), DGKA(1), DGKB(7), DGKD(2), DGKE(1), DGKG(6), DGKI(11), DGKQ(3), DGKZ(2), ESCO1(1), ETNK1(2), GNPAT(1), GPAM(1), GPD1(2), GPD1L(1), MYST3(3), MYST4(2), PCYT1A(1), PCYT1B(1), PEMT(1), PLA2G2D(2), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), PLD1(5), PLD2(1), PNPLA3(1), PPAP2C(1), SH3GLB1(1) 9297537 85 40 83 45 43 9 3 21 9 0 0.632 1.000 1.000 433 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 34 CRKL(1), DOCK1(2), ELK1(1), FOS(1), GRB2(1), HGF(7), ITGA1(3), ITGB1(1), JUN(1), MAP2K1(3), MAP2K2(2), MAP4K1(3), MAPK1(1), MET(8), PAK1(2), PIK3CA(3), PIK3R1(3), PTK2(2), PTK2B(4), PTPN11(2), PXN(1), RAF1(3), RASA1(1), SOS1(3), STAT3(6) 6106821 65 40 63 29 35 5 4 14 6 1 0.596 1.000 1.000 434 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(2), EIF2B1(3), EIF2S1(1), ELAVL1(1), FLT1(8), FLT4(3), HIF1A(3), KDR(8), NOS3(6), PIK3CA(3), PIK3R1(3), PLCG1(6), PRKCA(2), PTK2(2), PXN(1), VHL(1) 4867123 53 40 51 26 30 2 2 11 7 1 0.600 1.000 1.000 435 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(1), BIRC3(3), CASP10(1), CASP3(1), CASP8(4), CHUK(1), DFFA(1), FAS(1), FASLG(4), GZMB(1), HELLS(1), IKBKB(3), IRF1(1), IRF2(3), IRF3(1), IRF4(3), IRF6(2), IRF7(2), JUN(1), MAP2K4(1), MAP3K1(1), MAPK10(2), MDM2(2), NFKB1(1), NFKBIA(1), PLEKHG5(2), RELA(2), TNFRSF21(1), TNFRSF25(1), TNFSF10(3), TP73(1), TRAF1(1), TRAF3(2) 8018586 56 39 56 28 29 7 5 12 3 0 0.546 1.000 1.000 436 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(3), AGTR2(4), CALM2(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CDK5(1), F2(2), FYN(1), GNAI1(1), GRB2(1), JAK2(2), MAP2K1(3), MAP2K2(2), MAPK1(1), MAPK14(2), MAPT(1), MYLK(9), PLCG1(6), PRKCA(2), PTK2B(4), RAF1(3), SOS1(3), STAT3(6), STAT5A(1), SYT1(8) 5894853 74 39 71 30 40 8 5 11 10 0 0.167 1.000 1.000 437 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(2), AGXT(7), AGXT2(5), ALAS1(1), ALAS2(3), AMT(1), AOC2(4), AOC3(2), BHMT(1), CBS(1), CHDH(1), CHKA(1), CHKB(1), CPT1B(4), CTH(1), DAO(3), DMGDH(6), GAMT(1), GARS(2), GATM(2), GCAT(2), GLDC(2), MAOA(2), MAOB(4), PEMT(1), PLCB2(1), PLCG1(6), PLCG2(6), PSPH(1), SARDH(2), SARS(6), SHMT1(1), TARS(1) 5994671 84 39 84 30 52 9 3 13 7 0 0.0102 1.000 1.000 438 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), ALOX12(2), CYP4F2(6), CYP4F3(4), GGT1(2), LPO(5), LTA4H(2), MPO(4), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), PRDX6(1), PTGIS(2), PTGS1(7), PTGS2(2), TBXAS1(3), TPO(12) 3960131 63 39 63 39 46 5 2 5 5 0 0.400 1.000 1.000 439 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(3), AKT2(2), AKT3(1), ARHGEF11(4), CDC42(2), DLG4(1), LPA(10), MAP2K4(1), MAP3K1(1), MAP3K5(5), NFKB1(1), NFKB2(2), NFKBIA(1), NFKBIL1(2), NFKBIL2(2), PHKA2(3), PI3(1), PIK3CB(9), PLD1(5), PLD2(1), PTK2(2), RDX(1), ROCK1(2), ROCK2(6), SERPINA4(7) 6985417 75 38 75 34 34 6 7 19 9 0 0.457 1.000 1.000 440 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(2), AGXT(7), AGXT2(5), AKR1B10(3), ALAS1(1), ALAS2(3), AMT(1), AOC2(4), AOC3(2), BHMT(1), CBS(1), CHDH(1), CHKA(1), CHKB(1), CTH(1), DAO(3), DMGDH(6), GAMT(1), GARS(2), GATM(2), GCAT(2), GLDC(2), HSD3B7(2), MAOA(2), MAOB(4), PEMT(1), PHGDH(5), PIPOX(2), PSPH(1), RDH11(1), RDH12(1), RDH13(1), SARDH(2), SARS(6), SARS2(1), SHMT1(1), TARS(1), TARS2(1) 6089485 84 37 82 30 51 9 1 14 9 0 0.0164 1.000 1.000 441 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 29 ADCY3(1), ADRBK2(1), ARRB2(1), CALM2(1), CALML3(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CLCA1(2), CLCA2(2), CLCA4(4), CNGA3(5), CNGA4(5), CNGB1(5), GNAL(2), GUCA1A(2), GUCA1B(1), PDC(3), PDE1C(10), PRKACA(2), PRKACB(3), PRKACG(3), PRKG1(2), PRKG2(4), PRKX(1) 4242942 68 37 67 34 41 6 1 10 10 0 0.330 1.000 1.000 442 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 AGPAT3(4), AGPAT4(1), AGPS(1), CDS1(2), CDS2(2), CHAT(3), CHKA(1), CHKB(1), CPT1B(4), DGKA(1), DGKB(7), DGKD(2), DGKE(1), DGKG(6), DGKQ(3), DGKZ(2), ETNK1(2), GNPAT(1), GPD1(2), LGALS13(2), PAFAH1B1(2), PCYT1A(1), PCYT1B(1), PEMT(1), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), PLCB2(1), PLCG1(6), PLCG2(6), PPAP2C(1) 7109231 76 36 76 36 41 7 4 18 6 0 0.250 1.000 1.000 443 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(6), ATP4A(4), ATP5C1(1), ATP5F1(2), ATP5J(1), ATP5O(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(4), ATP6V0D2(1), ATP6V0E1(1), ATP6V1B1(3), ATP6V1C2(2), ATP6V1G3(1), COX15(1), COX6B1(1), COX6C(1), COX7B(1), COX7B2(2), COX8C(1), CYC1(3), NDUFA12(1), NDUFA13(1), NDUFA9(1), NDUFB2(1), NDUFB5(1), NDUFB6(1), NDUFS3(1), NDUFV1(2), PPA1(1), PPA2(2), SDHB(1), TCIRG1(2), UQCRC1(2) 7977878 59 36 59 27 35 3 5 12 4 0 0.280 1.000 1.000 444 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 29 C1GALT1(1), GALNT1(1), GALNT10(5), GALNT12(2), GALNT13(7), GALNT14(5), GALNT2(1), GALNT5(3), GALNT6(2), GALNT7(2), GALNT8(5), GALNT9(2), GALNTL1(1), GALNTL2(3), GALNTL4(2), GALNTL5(6), GCNT1(3), GCNT3(4), GCNT4(1), OGT(2), ST3GAL2(1), ST6GALNAC1(2) 4428297 61 36 60 26 47 0 2 5 7 0 0.185 1.000 1.000 445 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(6), ACACB(3), ACAT2(1), ACOT12(4), ACSS1(1), ACSS2(1), AKR1B1(1), ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1), DLAT(1), GRHPR(1), HAGH(1), LDHA(1), LDHAL6A(4), LDHAL6B(1), LDHB(2), LDHC(2), MDH2(1), ME1(8), ME2(1), ME3(4), PC(7), PCK1(3), PCK2(1), PDHA1(1), PDHA2(6), PKLR(2), PKM2(1) 6670033 72 36 71 31 44 4 3 16 5 0 0.159 1.000 1.000 446 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(3), CARS(4), CARS2(1), DARS2(2), EPRS(5), FARS2(1), FARSA(2), FARSB(1), GARS(2), HARS(2), HARS2(2), IARS(2), IARS2(1), LARS(3), MARS(2), MARS2(1), NARS(1), NARS2(1), QARS(1), RARS(1), SARS(6), SARS2(1), TARS(1), TARS2(1), VARS(4), VARS2(3), WARS(1), WARS2(2), YARS2(1) 7793965 58 36 57 21 32 7 4 11 4 0 0.154 1.000 1.000 447 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(3), CR1(14), CR2(8), FCGR2B(1), HLA-DRA(3), HLA-DRB1(1), ITGAL(6), ITGB2(2), PTPRC(16) 2146957 54 35 53 25 36 4 3 8 3 0 0.460 1.000 1.000 448 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(1), APAF1(1), BAG4(3), BIRC3(3), CASP3(1), CASP8(4), CHUK(1), DAXX(1), DFFA(1), LMNA(4), LMNB1(1), LMNB2(2), MAP2K7(1), MAP3K1(1), MAP3K5(5), MDM2(2), NFKB1(1), NFKBIA(1), NUMA1(2), PAK2(5), PRKCD(2), PRKDC(6), PSEN1(1), PSEN2(2), PTK2(2), RASA1(1), RB1(2), RELA(2), SPTAN1(2), TRAF1(1) 9862548 62 35 62 31 22 9 6 22 2 1 0.709 1.000 1.000 449 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACADM(1), ACAT2(1), ALDH1B1(2), ALDH3A1(1), ALDH6A1(2), ALDH7A1(3), ALDH9A1(1), AOX1(5), BCAT1(4), BCKDHB(1), ECHS1(1), EHHADH(2), HADHA(4), HIBADH(4), HMGCS1(1), HMGCS2(5), HSD17B10(2), HSD17B4(4), IVD(1), MCEE(2), MUT(2), OXCT1(2), OXCT2(1), PCCA(2) 6154587 55 35 54 29 28 6 5 12 4 0 0.716 1.000 1.000 450 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ADCY3(1), ADCY9(5), ARF4(2), ARF5(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(4), ATP6V0D2(1), ATP6V0E1(1), ATP6V1C2(2), ATP6V1G3(1), ERO1L(1), GNAS(5), PDIA4(1), PLCG1(6), PLCG2(6), PRKCA(2), SEC61A2(5), TRIM23(1) 5279898 51 35 51 30 29 1 3 12 6 0 0.735 1.000 1.000 451 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 AKT1(3), ANGPTL2(1), DAG1(1), DGKA(1), ITGA9(4), ITPKB(1), ITPR1(10), ITPR2(3), ITPR3(3), MAP2K1(3), MAPK1(1), NR1I3(2), PAK1(2), PDE3A(3), PDE3B(3), PI3(1), PIK3C2G(10), PIK3CA(3), PIK3CD(3), PIK3R1(3), RIPK3(3), VASP(1) 6897884 65 35 63 23 41 4 5 10 4 1 0.0365 1.000 1.000 452 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 41 AKT1(3), ATF1(3), CREB5(2), CREBBP(4), CRKL(1), DAG1(1), EGR2(2), EGR4(1), ELK1(1), FRS2(1), GNAQ(1), JUN(1), MAP1B(5), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK8IP1(1), MAPK8IP2(1), MAPK9(1), NTRK1(5), OPN1LW(1), PIK3C2G(10), PIK3CA(3), PIK3CD(3), PIK3R1(3), PTPN11(2), RPS6KA3(1), TH(4) 7052099 66 35 66 29 38 5 2 16 4 1 0.355 1.000 1.000 453 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 CHUK(1), DAXX(1), EGF(3), EGFR(4), ETS1(1), ETS2(2), FOS(1), IKBKB(3), JUN(1), MAP2K1(3), MAP2K3(4), MAP2K4(1), MAP2K6(1), MAP2K7(1), MAP3K1(1), MAP3K5(5), MAPK1(1), MAPK13(1), MAPK14(2), NFKB1(1), NFKBIA(1), PRKCA(2), PRKCD(2), PRKCE(2), PRKCG(5), PRKCH(4), PRKCQ(2), RAF1(3), RELA(2) 6965468 61 34 59 33 31 8 3 13 6 0 0.636 1.000 1.000 454 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(2), ADC(1), AGMAT(1), ALDH18A1(3), ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1), AOC2(4), AOC3(2), ARG1(1), ASL(2), ASS1(2), CPS1(5), GATM(2), MAOA(2), MAOB(4), ODC1(3), OTC(1), SMS(4) 4162305 46 33 46 25 26 4 3 7 6 0 0.455 1.000 1.000 455 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(6), AXIN1(3), CREBBP(4), CTNNB1(6), EP300(1), FZD1(2), GSK3B(1), HDAC1(1), LDB1(1), LEF1(1), PITX2(1), TRRAP(15), WNT1(1) 4739000 43 33 42 20 21 2 3 9 8 0 0.647 1.000 1.000 456 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1L(1), GTF2A2(1), GTF2E1(1), GTF2E2(2), GTF2F1(3), GTF2H1(1), GTF2IRD1(2), TAF1(3), TAF1L(10), TAF2(2), TAF4(1), TAF4B(1), TAF6(2), TAF6L(3), TAF7(1), TAF7L(5), TAF9(1), TAF9B(1), TBPL1(1), TBPL2(2) 5168799 44 32 44 16 22 4 3 12 3 0 0.487 1.000 1.000 457 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(1), ACTN2(4), BCAR1(1), BCR(2), CAPN1(2), CRKL(1), CSK(1), FYN(1), GRB2(1), ITGA1(3), ITGB1(1), JUN(1), MAP2K1(3), MAP2K2(2), MAPK1(1), PPP1R12B(4), PTK2(2), PXN(1), RAF1(3), ROCK1(2), SOS1(3), TLN1(2), VCL(2), ZYX(2) 6640278 46 32 44 20 21 6 3 11 5 0 0.378 1.000 1.000 458 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(3), ADRA1D(1), ADRA2C(1), CHRM2(3), CHRM3(8), CHRM4(1), CHRM5(1), DRD1(1), DRD2(7), DRD5(8), HRH1(3), HTR1A(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2C(3), HTR4(3), HTR5A(3), HTR7(3) 3587145 53 32 52 38 33 7 2 9 2 0 0.273 1.000 1.000 459 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(5), DLG4(1), EPHB2(8), F2(2), F2RL1(3), F2RL2(2), F2RL3(2), JUN(1), MAPK1(1), MAPK7(1), MYEF2(3), PLD1(5), PLD2(1), PTK2(2), RAF1(3), RASAL1(3), TEC(4), VAV1(5) 3898198 52 32 51 25 26 5 4 14 3 0 0.533 1.000 1.000 460 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(3), ATF1(3), CDC42(2), CREB5(2), ELK1(1), HSPB1(1), IL1R1(2), MAP2K3(4), MAP2K4(1), MAP2K6(1), MAP3K10(5), MAP3K4(5), MAP3K5(5), MAPK1(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPKAPK2(2), MAPKAPK5(1), MKNK1(2), MYEF2(3), NFKB1(1), TRAF6(1) 4736357 51 32 51 25 29 5 1 11 5 0 0.457 1.000 1.000 461 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACADM(1), ACADSB(2), ACAT2(1), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH6A1(2), ALDH9A1(1), AOX1(5), BCAT1(4), BCKDHB(1), ECHS1(1), EHHADH(2), HADHA(4), HIBADH(4), IVD(1), MCEE(2), MUT(2), OXCT1(2), PCCA(2) 5155419 43 32 42 25 23 5 2 9 4 0 0.819 1.000 1.000 462 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(2), APC(6), ATF2(2), AXIN1(3), BMP10(3), BMP2(1), BMP5(4), BMPR1A(1), BMPR2(2), CHRD(2), CTNNB1(6), FZD1(2), GSK3B(1), MYL2(1), NPPA(1), RFC1(2), TGFB3(2), TGFBR2(2), TGFBR3(1), WNT1(1) 5149781 45 31 44 19 26 3 2 7 7 0 0.413 1.000 1.000 463 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 32 AGT(3), AGTR1(2), ATF2(2), CALM2(1), EGFR(4), ELK1(1), GNAQ(1), GRB2(1), JUN(1), MAP2K1(3), MAP2K2(2), MAP2K4(1), MAP3K1(1), MAPK1(1), MEF2A(1), MEF2D(1), PAK1(2), PRKCA(2), PTK2(2), PTK2B(4), RAF1(3), SOS1(3), SYT1(8) 4703258 50 31 47 28 28 3 4 9 6 0 0.836 1.000 1.000 464 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 25 ADCY1(12), AKT1(3), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), GNAS(5), GRB2(1), MAPK1(1), MAPK14(2), PIK3CA(3), PIK3R1(3), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCA(2), RPS6KA1(1), RPS6KA5(1), SOS1(3) 4054589 54 31 54 24 30 3 3 6 11 1 0.392 1.000 1.000 465 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(1), GNAI1(1), GNAQ(1), MAP2K1(3), MAPK1(1), NFKB1(1), PIK3C2G(10), PIK3CA(3), PIK3R1(3), PLCG1(6), PRKCA(2), PTK2(2), PTK2B(4), PXN(1), RAF1(3), RELA(2) 3919898 44 31 42 19 24 2 2 11 4 1 0.438 1.000 1.000 466 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(1), EGFR(4), ELK1(1), GNAS(5), GRB2(1), IGF1R(4), ITGB1(1), KLK2(1), MAP2K1(3), MAP2K2(2), MAPK1(1), MKNK1(2), PDGFRA(5), PTPRR(4), RAF1(3), RPS6KA1(1), RPS6KA5(1), SOS1(3), STAT3(6) 4677040 49 31 47 31 27 6 3 9 4 0 0.891 1.000 1.000 467 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(5), CALCR(3), CALCRL(5), CD97(2), CRHR1(1), CRHR2(1), ELTD1(5), EMR1(8), EMR2(1), GHRHR(1), GLP1R(4), GLP2R(4), GPR64(2), LPHN1(3), LPHN2(9), LPHN3(5), SCTR(2), VIPR1(1) 3760718 62 31 61 34 45 2 5 6 4 0 0.213 1.000 1.000 468 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(2), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), AOC2(4), AOC3(2), DDC(4), ESCO1(1), GOT1(3), GOT2(1), HPD(2), LPO(5), MAOA(2), MAOB(4), MPO(4), MYST3(3), MYST4(2), PNPLA3(1), PRDX6(1), SH3GLB1(1), TAT(4), TPO(12) 4881900 62 31 62 43 46 5 1 8 2 0 0.846 1.000 1.000 469 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(6), ACACB(3), ACADM(1), ACAT2(1), ACSS1(1), ACSS2(1), ALDH1B1(2), ALDH3A1(1), ALDH6A1(2), ALDH7A1(3), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(4), LDHA(1), LDHAL6A(4), LDHAL6B(1), LDHB(2), LDHC(2), MCEE(2), MUT(2), PCCA(2), SUCLG2(1) 5676934 47 31 47 21 24 5 3 12 3 0 0.410 1.000 1.000 470 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(3), CBL(1), CRKL(1), FOS(1), GRB2(1), IL2RA(1), IL2RB(2), IRS1(1), JAK1(2), JAK3(1), MAPK1(1), NMI(1), PIK3CA(3), PIK3R1(3), PTPN6(2), RAF1(3), SOCS3(1), SOS1(3), STAT5A(1), STAT5B(1), SYK(5) 5112193 38 31 38 17 24 2 2 5 4 1 0.448 1.000 1.000 471 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(2), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), AOC2(4), AOC3(2), DDC(4), GOT1(3), GOT2(1), HPD(2), LPO(5), MAOA(2), MAOB(4), MPO(4), PRDX6(1), TAT(4), TPO(12) 3121707 54 31 54 34 43 4 1 4 2 0 0.420 1.000 1.000 472 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 25 ALAD(1), CP(3), EPRS(5), GUSB(3), HCCS(2), HMOX1(1), UGT1A1(2), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(1), UGT1A8(2), UGT1A9(4), UGT2B4(7) 3645406 39 31 39 21 23 5 2 4 5 0 0.670 1.000 1.000 473 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(6), ACAT2(1), ADH5(1), AKR1B1(1), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH9A1(1), DLAT(1), GRHPR(1), HAGH(1), LDHA(1), LDHB(2), LDHC(2), MDH2(1), ME1(8), ME2(1), ME3(4), PC(7), PCK1(3), PDHA1(1), PDHA2(6), PKLR(2), PKM2(1) 5275621 58 31 57 28 37 5 2 11 3 0 0.364 1.000 1.000 474 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP5(3), ARHGAP6(4), ARHGEF11(4), ARHGEF5(3), ARPC2(1), ARPC4(1), BAIAP2(3), CFL1(1), MYL2(1), MYLK(9), OPHN1(1), PIP5K1A(1), PIP5K1B(4), PPP1R12B(4), ROCK1(2), TLN1(2), VCL(2) 6402993 46 31 46 22 25 2 1 9 9 0 0.409 1.000 1.000 475 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(2), AKT1(3), AKT2(2), AKT3(1), DAG1(1), GNAQ(1), ITPKB(1), ITPR1(10), ITPR2(3), ITPR3(3), NFKB1(1), NFKB2(2), NFKBIA(1), NFKBIL1(2), NFKBIL2(2), PHKA2(3), PIK3CB(9), PITX2(1), PLD1(5), PLD2(1) 6364113 54 31 54 30 18 8 8 15 5 0 0.672 1.000 1.000 476 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGF(3), EGFR(4), ELK1(1), FOS(1), GRB2(1), JAK1(2), JUN(1), MAP2K1(3), MAP2K4(1), MAP3K1(1), PIK3CA(3), PIK3R1(3), PLCG1(6), PRKCA(2), RAF1(3), RASA1(1), SOS1(3), STAT3(6), STAT5A(1) 5337191 46 30 44 20 21 4 4 12 4 1 0.587 1.000 1.000 477 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(2), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), ALDH9A1(1), AOC2(4), AOC3(2), CNDP1(3), DDC(4), HAL(6), HARS(2), HDC(6), MAOA(2), MAOB(4), PRPS1(2), PRPS2(1) 3469170 48 30 48 30 32 5 1 5 5 0 0.623 1.000 1.000 478 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLA2(2), POLD1(2), POLD3(1), POLE(4), POLE2(1), POLG(4), POLG2(1), POLI(1), POLK(2), POLL(1), POLQ(7), PRIM1(2), PRIM2(5), REV3L(3) 5780075 37 30 37 16 24 1 1 6 5 0 0.614 1.000 1.000 479 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(6), ATP5O(1), ATP6V0A1(3), ATP6V0A4(4), ATP6V1B1(3), ATP6V1C2(2), ATP6V1G3(1), ATP7A(3), ATP7B(4), COX6B1(1), COX6C(1), COX7B(1), NDUFB2(1), NDUFB5(1), NDUFB6(1), NDUFV1(2), PPA2(2), SDHB(1), SHMT1(1), UQCRC1(2) 5464019 41 30 41 21 25 0 5 9 2 0 0.528 1.000 1.000 480 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK8IP1(1), MAPK8IP2(1), MAPK9(1), MAPKAPK5(1), NFKB1(1), NFKB2(2), NFKBIA(1), NFKBIL1(2), NFKBIL2(2), PIK3CA(3), PIK3CD(3), PIK3R1(3), SYT1(8), TRAF3(2), TRAF5(2), TRAF6(1) 4748516 44 30 43 22 20 6 4 11 2 1 0.472 1.000 1.000 481 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(2), CARM1(1), CREBBP(4), EP300(1), ERCC3(1), ESR1(2), GRIP1(2), GTF2E1(1), GTF2F1(3), HDAC1(1), HDAC2(1), HDAC4(3), HDAC6(1), NCOR2(8), NR0B1(1), NRIP1(2), PELP1(1), POLR2A(4), TBP(2) 6462377 41 29 41 23 24 1 4 8 4 0 0.847 1.000 1.000 482 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 22 ABL1(6), ATM(6), ATR(6), CCNA1(8), CCNE1(1), CDC25A(1), CDK6(1), CDKN1A(1), GSK3B(1), HDAC1(1), RB1(2), TGFB3(2) 4007200 36 29 36 19 19 3 3 7 3 1 0.725 1.000 1.000 483 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSE(1), ENPP7(1), GAL3ST1(3), GALC(1), GLB1(2), LCT(6), NEU1(3), NEU2(3), NEU3(1), NEU4(4), PPAP2C(1), SGMS1(3), SMPD1(2), SMPD3(2), SMPD4(1), SPHK1(1), SPHK2(1), SPTLC2(1), UGT8(3) 5036568 40 29 40 32 23 4 1 8 4 0 0.958 1.000 1.000 484 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(1), ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1), CYP2C19(6), CYP2C9(10), DHRS1(1), DHRS2(3), DHRS3(2), DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(1), HADHA(4), MYST3(3), MYST4(2), PNPLA3(1), SH3GLB1(1) 4418569 46 29 45 32 26 8 1 8 3 0 0.916 1.000 1.000 485 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(3), ARSB(1), GALNS(1), GLB1(2), GNS(1), GUSB(3), HEXB(1), HGSNAT(2), HPSE(4), IDS(4), LCT(6), MAN2B1(3), MAN2B2(2), MAN2C1(2), MANBA(2), NAGLU(2), NEU1(3), NEU2(3), NEU3(1), NEU4(4), SPAM1(4) 4856168 54 29 54 23 34 4 1 9 6 0 0.231 1.000 1.000 486 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(4), EP300(1), FYN(1), IL7(2), IL7R(10), JAK1(2), JAK3(1), LCK(1), NMI(1), PIK3CA(3), PIK3R1(3), PTK2B(4), STAT5A(1), STAT5B(1) 3965796 35 29 35 16 18 3 1 9 3 1 0.585 1.000 1.000 487 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(2), AASDHPPT(3), AASS(2), ACAT2(1), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH9A1(1), BBOX1(1), DOT1L(3), ECHS1(1), EHHADH(2), EHMT1(1), EHMT2(5), GCDH(3), HADHA(4), PLOD1(2), PLOD2(1), PLOD3(2), SHMT1(1) 5247738 42 29 41 22 23 5 2 9 3 0 0.527 1.000 1.000 488 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 38 ATF2(2), CDC42(2), DAXX(1), DDIT3(1), ELK1(1), GRB2(1), HSPB1(1), HSPB2(1), MAP2K4(1), MAP2K6(1), MAP3K1(1), MAP3K5(5), MAP3K9(5), MAPK14(2), MAPKAPK2(2), MAPKAPK5(1), MEF2A(1), MEF2D(1), MKNK1(2), PLA2G4A(4), RPS6KA5(1), TGFB3(2) 5117771 39 29 39 24 17 1 2 8 11 0 0.902 1.000 1.000 489 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 CHAT(3), COMT(1), DBH(5), DDC(4), GAD1(5), GAD2(4), HDC(6), MAOA(2), PAH(3), TH(4), TPH1(2) 2001721 39 28 39 20 33 2 0 2 2 0 0.167 1.000 1.000 490 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(3), FYN(1), ITGA1(3), ITGB1(1), MAP2K1(3), MAPK1(1), MYL2(1), MYLK(9), PIK3CA(3), PIK3R1(3), PTK2(2), PXN(1), RAF1(3), ROCK1(2), TLN1(2) 5310694 38 28 36 21 21 3 3 7 3 1 0.724 1.000 1.000 491 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(1), GABRA1(5), GABRA2(8), GABRA3(7), GABRA4(4), GABRA6(8), GPHN(4), UBQLN1(1) 1677796 38 28 34 17 27 0 1 6 3 1 0.301 1.000 1.000 492 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH5(1), ADH6(3), ADH7(5), DHRS1(1), DHRS2(3), DHRS3(2), DHRS7(1), ESCO1(1), MYST3(3), MYST4(2), PNPLA3(1), SH3GLB1(1) 3578082 43 28 41 21 30 6 1 6 0 0 0.561 1.000 1.000 493 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 CAPN1(2), CAPN2(2), CXCR3(1), EGF(3), EGFR(4), ITGA1(3), ITGB1(1), MAPK1(1), MYL2(1), MYLK(9), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PTK2(2), PXN(1), TLN1(2) 4618780 42 28 42 26 24 4 2 7 5 0 0.740 1.000 1.000 494 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 ERCC3(1), GTF2A2(1), GTF2E1(1), GTF2E2(2), GTF2H1(1), MNAT1(2), POLR1A(2), POLR1B(1), POLR2A(4), POLR2B(4), POLR2C(1), POLR2H(2), POLR3B(7), POLR3E(2), POLR3H(1), TAF6(2), TAF7(1), TAF9(1), TBP(2) 5009792 38 28 38 14 16 5 6 11 0 0 0.380 1.000 1.000 495 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 23 ATF2(2), BCR(2), BLNK(2), ELK1(1), FOS(1), GRB2(1), JUN(1), LYN(2), MAP2K1(3), MAP3K1(1), MAPK1(1), PAPPA(9), RPS6KA1(1), RPS6KA3(1), SOS1(3), SYK(5), VAV1(5), VAV3(1) 4472192 42 28 40 30 28 1 1 7 5 0 0.920 1.000 1.000 496 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(2), DYRK1B(1), GLI2(8), GLI3(7), GSK3B(1), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), SHH(2), SMO(3), SUFU(1) 2361273 35 28 35 17 20 2 2 5 6 0 0.457 1.000 1.000 497 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(1), EGF(3), EGFR(4), GRB2(1), MAP2K1(3), MAPK1(1), PTPRB(17), RAF1(3), RASA1(1), SOS1(3), SPRY1(1), SPRY2(3), SPRY3(5) 3565978 46 28 42 22 31 4 1 7 3 0 0.591 1.000 1.000 498 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(6), ATR(6), BRCA1(2), BRCA2(9), CHEK1(1), CHEK2(1), FANCA(2), FANCC(1), FANCD2(3), FANCE(1), FANCG(1), HUS1(1), MRE11A(1), RAD17(1), RAD50(2), RAD9A(2) 6181751 40 27 40 23 24 2 2 10 2 0 0.917 1.000 1.000 499 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(1), AZIN1(1), CBX3(1), CLOCK(1), CRY1(1), CRY2(1), DAZAP2(1), DNAJA1(1), EIF4G2(1), ETV6(3), GSTM3(1), GSTP1(1), HSPA8(2), IDI1(1), MYF6(4), NCKAP1(2), NCOA4(1), NR1D2(2), PER1(2), PER2(5), PPP1R3C(1), PURA(1), SF3A3(1), TUBB3(1), UCP3(3), ZFR(2) 5195887 42 27 42 21 18 4 2 9 9 0 0.776 1.000 1.000 500 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(9), F2(2), F2R(1), FGA(8), FGB(5), FGG(3), PLAU(1), PLG(4), SERPINB2(4), SERPINE1(1) 1906826 38 27 38 17 24 3 1 7 3 0 0.492 1.000 1.000 501 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH5(1), ADH6(3), ADH7(5), ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1) 1888368 35 27 33 16 25 4 2 3 1 0 0.287 1.000 1.000 502 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(8), ACE2(3), AGT(3), AGTR1(2), AGTR2(4), ANPEP(4), CMA1(1), CPA3(5), CTSA(1), CTSG(1), ENPEP(6), LNPEP(5), MAS1(1), MME(6), NLN(2), REN(3), THOP1(1) 3002697 56 27 55 31 39 6 4 6 1 0 0.398 1.000 1.000 503 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), CASP10(1), CASP3(1), CASP8(4), CD40(2), DAXX(1), DFFA(1), FAS(1), FASLG(4), IKBKE(4), MCL1(2), NFKB1(1), NFKBIA(1), NTRK1(5), PTPN13(4), SFRS2IP(2), TRAF1(1), TRAF3(2), TRAF6(1) 6179613 39 26 39 20 22 3 4 7 3 0 0.590 1.000 1.000 504 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(12), GNAI1(1), GNAS(5), MAPK1(1), MYT1(7), PIN1(1), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RPS6KA1(1) 2916351 38 26 38 24 22 3 3 3 7 0 0.692 1.000 1.000 505 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 17 AKR1B1(1), GUSB(3), UGDH(1), UGT1A1(2), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(1), UGT1A8(2), UGT1A9(4), UGT2B4(7) 2234011 29 26 29 16 21 2 2 1 3 0 0.469 1.000 1.000 506 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(6), ACADM(1), ACADSB(2), ACAT2(1), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH6A1(2), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(4), LDHA(1), LDHB(2), LDHC(2), MCEE(2), MUT(2), PCCA(2), SUCLG2(1) 4740648 39 26 39 18 19 6 2 10 2 0 0.544 1.000 1.000 507 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 ATF1(3), CREB5(2), DUSP6(1), GRB2(1), MAP2K1(3), MAP2K2(2), MAPK1(1), MKNK1(2), MOS(1), NFKB1(1), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), SOS1(3), SOS2(4), TRAF3(2) 3973284 33 26 31 20 20 1 2 7 3 0 0.883 1.000 1.000 508 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), DAG1(1), ITPKB(1), ITPR1(10), ITPR2(3), ITPR3(3), NFAT5(2), PDE6B(2), PDE6C(7), PDE6D(1), PDE6G(1), SLC6A13(9), TF(3) 5066845 50 26 48 28 33 4 3 3 7 0 0.339 1.000 1.000 509 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(12), CFTR(11), GNAS(5), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), SLC9A3R1(1) 1847008 39 25 39 19 23 3 4 3 6 0 0.400 1.000 1.000 510 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(1), BIRC3(3), CASP10(1), CASP3(1), CASP8(4), CHUK(1), DFFA(1), GAS2(3), LMNA(4), NFKB1(1), NFKBIA(1), RELA(2), SPTAN1(2), TNFRSF10A(3), TNFRSF25(1), TNFSF10(3) 4753130 32 25 32 17 16 4 3 9 0 0 0.723 1.000 1.000 511 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(6), ATR(6), BRCA1(2), CDC25A(1), CDC34(1), CDKN1A(1), CHEK1(1), CHEK2(1), EP300(1), MDM2(2), MYT1(7), PRKDC(6), RPS6KA1(1), YWHAQ(1) 5887422 37 25 37 26 17 3 3 10 4 0 0.987 1.000 1.000 512 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(2), ACO1(3), ACO2(1), CLYBL(2), CS(1), IDH1(3), IDH2(1), IDH3G(1), MDH2(1), OGDH(4), OGDHL(10), PC(7), PCK1(3), PCK2(1), SDHB(1), SUCLG2(1) 4270670 42 25 40 19 24 0 2 11 5 0 0.396 1.000 1.000 513 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(3), CA1(3), CA12(1), CA13(2), CA2(1), CA3(3), CA4(1), CA5A(1), CA6(1), CA7(1), CA8(2), CA9(2), CPS1(5), CTH(1), GLS(1), GLUL(2), HAL(6) 3006144 37 25 37 18 24 1 2 8 2 0 0.529 1.000 1.000 514 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(3), CA1(3), CA12(1), CA2(1), CA3(3), CA4(1), CA5A(1), CA6(1), CA7(1), CA8(2), CA9(2), CPS1(5), CTH(1), GLS(1), GLUL(2), HAL(6) 2687692 35 25 35 16 22 1 2 8 2 0 0.470 1.000 1.000 515 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(3), EGFR(4), IGF1R(4), POLR2A(4), PRKCA(2), RB1(2), TEP1(5), TERF1(1), TERT(1), TNKS(2), XRCC5(2) 3884923 30 25 30 20 18 3 1 5 2 1 0.770 1.000 1.000 516 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(1), EEF1G(1), EIF1AX(1), EIF2AK1(1), EIF2AK3(9), EIF2B1(3), EIF2S1(1), EIF4A1(1), EIF4A2(2), EIF4G1(2), EIF4G3(4), EIF5B(1), GSPT2(2), KIAA0664(1), PABPC1(2), PABPC3(1), SLC35A4(2) 6213482 35 25 32 30 16 2 2 7 8 0 0.998 1.000 1.000 517 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(12), GNAS(5), PRKAA2(6), PRKAB1(1), PRKACB(3), PRKACG(3), PRKAG1(1), PRKAG2(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1) 2173625 38 24 38 16 22 3 4 2 7 0 0.284 1.000 1.000 518 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP10(1), CASP3(1), CASP8(4), DAXX(1), DFFA(1), FAF1(4), JUN(1), LMNA(4), LMNB1(1), LMNB2(2), MAP2K4(1), MAP3K1(1), PAK1(2), PAK2(5), PRKDC(6), PTPN13(4), RB1(2), RIPK2(1), SPTAN1(2) 5871848 44 24 44 21 15 4 6 16 2 1 0.819 1.000 1.000 519 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(3), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K6(1), MAP3K1(1), MAPK1(1), MAPK14(2), NFKB1(1), PIK3CA(3), PIK3R1(3), RB1(2), RELA(2) 2759754 28 24 26 12 12 3 0 8 3 2 0.623 1.000 1.000 520 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(2), CARM1(1), CBS(1), CTH(1), GGT1(2), HEMK1(2), LCMT1(2), MARS(2), MARS2(1), MAT1A(2), MAT2B(2), METTL2B(2), METTL6(1), PAPSS1(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT8(1), SCLY(1), SEPHS1(1), WBSCR22(1) 3573864 30 24 30 16 14 3 3 5 5 0 0.558 1.000 1.000 521 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(8), ANAPC4(1), ANAPC5(2), ANAPC7(3), CDC23(2), CUL1(2), CUL2(1), FBXW11(1), FBXW7(4), FZR1(2), ITCH(1), SMURF2(1), UBA1(1), UBE2D1(1), VHL(1), WWP1(1), WWP2(1) 5685652 33 24 32 18 20 0 4 9 0 0 0.890 1.000 1.000 522 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(2), ALDOC(2), FBP1(1), FBP2(1), G6PD(1), GPI(1), H6PD(2), PFKM(1), PGD(2), PGLS(1), PGM1(3), PRPS1(2), PRPS1L1(2), PRPS2(1), RBKS(1), TAL1(3), TKT(4) 2901280 30 24 30 17 16 4 3 2 5 0 0.462 1.000 1.000 523 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), CSF1R(4), EGF(3), EGFR(4), GRB2(1), MET(8), PDGFRA(5), PRKCA(2), SH3GLB1(1), SH3KBP1(2) 2779235 31 23 31 19 18 5 2 3 3 0 0.786 1.000 1.000 524 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC7(1), DIAPH2(2), MCM10(3), MCM2(2), MCM3(1), MCM4(2), MCM5(1), MCM6(1), ORC1L(1), ORC4L(1), PCNA(2), POLA2(2), POLD1(2), POLD3(1), POLE(4), POLE2(1), PRIM1(2), RFC1(2), RPA1(2), RPA2(1), RPA3(1), RPA4(1), UBC(1) 7217372 37 23 37 24 18 2 1 11 5 0 0.917 1.000 1.000 525 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(3), EGFR(4), MAP2K1(3), MAP3K1(1), MAPK14(2), NCOR2(8), RARA(2), THRA(1), THRB(5) 2447385 29 23 27 15 20 2 1 5 1 0 0.548 1.000 1.000 526 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOB(2), ALDOC(2), FBP1(1), FBP2(1), FPGT(1), GCK(5), GMDS(2), GMPPA(1), HK1(2), HK2(4), HK3(3), PFKFB1(2), PFKM(1) 3382738 28 23 28 20 20 2 2 2 2 0 0.560 1.000 1.000 527 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(1), AKR1B10(3), ALDOB(2), ALDOC(2), FBP1(1), FBP2(1), FPGT(1), FUK(1), GMDS(2), GMPPA(1), HK1(2), HK2(4), HK3(3), HSD3B7(2), MTMR1(2), MTMR2(1), PFKFB1(2), PFKL(2), PFKM(1), RDH11(1), RDH12(1), RDH13(1), TSTA3(1) 5244589 38 23 38 27 23 4 3 6 2 0 0.682 1.000 1.000 528 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIA(3), CHIT1(3), CMAS(1), CTBS(1), GFPT1(2), GFPT2(3), GNE(1), HEXB(1), HK1(2), HK2(4), HK3(3), MTMR1(2), MTMR2(1), RENBP(2), UAP1(1) 4073534 30 23 30 17 15 2 2 5 6 0 0.677 1.000 1.000 529 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT3(4), AGPAT4(1), AGPAT6(1), AGPS(1), ENPP2(1), ENPP6(3), PAFAH1B1(2), PLA2G2D(2), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), PLD1(5), PLD2(1), PPAP2C(1) 3326533 31 23 31 16 16 5 2 6 2 0 0.536 1.000 1.000 530 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(5), ENPP1(4), ENPP3(4), NADK(1), NMNAT2(1), NMNAT3(5), NNMT(1), NT5C1A(1), NT5C1B(6), NT5C2(2), NT5E(1), QPRT(2) 3077396 33 23 33 25 19 2 1 6 5 0 0.948 1.000 1.000 531 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(7), ABP1(2), AOC2(4), AOC3(2), CES1(3), CES7(3), DDHD1(1), ESCO1(1), MYST3(3), MYST4(2), PLA1A(3), PNPLA3(1), PRDX6(1), SH3GLB1(1) 3616767 34 23 34 20 26 1 1 5 1 0 0.782 1.000 1.000 532 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 ELK1(1), FOS(1), GRB2(1), IGF1(5), IGF1R(4), IRS1(1), JUN(1), MAP2K1(3), PIK3CA(3), PIK3R1(3), PTPN11(2), RAF1(3), RASA1(1), SOS1(3) 3531501 32 23 30 13 18 2 1 8 2 1 0.508 1.000 1.000 533 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(9), ABCB11(5), ABCB4(4), ABCC1(4), ABCC3(6), GSTP1(1) 2034271 29 23 28 17 13 4 3 3 6 0 0.370 1.000 1.000 534 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GALNS(1), GLB1(2), GNS(1), GUSB(3), HEXB(1), HGSNAT(2), HPSE(4), IDS(4), LCT(6), NAGLU(2), SPAM1(4) 2898921 31 22 31 15 24 0 0 3 4 0 0.420 1.000 1.000 535 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(1), CREBBP(4), EP300(1), IKBKB(3), IL1B(2), MAP2K3(4), MAP2K6(1), MAPK11(1), MAPK14(2), NFKB1(1), NFKBIA(1), RELA(2), TGFBR2(2), TLR2(2) 4232733 27 22 26 19 9 6 1 9 2 0 0.962 1.000 1.000 536 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(12), GNAS(5), PLCE1(10), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1) 2081085 37 22 37 17 22 2 3 4 6 0 0.367 1.000 1.000 537 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(6), CASP3(1), CREB5(2), DAG1(1), EPHB2(8), FOS(1), GNAQ(1), ITPKB(1), JUN(1), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK8IP1(1), MAPK8IP2(1), MAPK9(1) 4049520 30 22 30 13 17 3 3 3 4 0 0.376 1.000 1.000 538 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 GBA3(4), LPO(5), MPO(4), PRDX6(1), TPO(12), TYR(4) 1377357 30 22 30 18 22 3 0 1 4 0 0.553 1.000 1.000 539 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 BAG4(3), CASP3(1), CASP8(4), DFFA(1), JUN(1), LMNA(4), LMNB1(1), LMNB2(2), MADD(4), MAP2K4(1), MAP3K1(1), PAK1(2), PAK2(5), PRKDC(6), RB1(2), SPTAN1(2) 5563329 40 22 40 20 13 4 6 16 0 1 0.774 1.000 1.000 540 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(12), FHL5(3), FSHB(2), FSHR(5), GNAS(5), XPO1(2) 1350286 29 21 28 13 18 2 4 2 3 0 0.393 1.000 1.000 541 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(1), ARSE(1), GAL3ST1(3), GALC(1), GLB1(2), LCT(6), NEU1(3), NEU2(3), NEU3(1), NEU4(4), PPAP2C(1), SMPD1(2), SPTLC2(1) 3409283 29 21 29 17 16 4 0 5 4 0 0.665 1.000 1.000 542 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(4), G6PD(1), GCLC(1), GGT1(2), GPX1(1), GPX5(2), GPX6(3), GSS(2), GSTA1(2), GSTM3(1), GSTM5(1), GSTP1(1), IDH1(3), IDH2(1), MGST1(1), MGST2(1), MGST3(1), OPLAH(2), TXNDC12(1) 3105743 31 21 30 16 19 3 2 6 1 0 0.332 1.000 1.000 543 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(3), GLB1(2), HEXB(1), LCT(6), MAN2B1(3), MAN2B2(2), MAN2C1(2), MANBA(2), NEU1(3), NEU2(3), NEU3(1), NEU4(4) 2881714 32 21 32 16 18 4 1 6 3 0 0.497 1.000 1.000 544 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(1), ATG5(1), ATG7(3), GABARAPL1(1), IFNA1(1), IFNA16(3), IFNA21(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNG(1), PIK3C3(1), PIK3R4(1), PRKAA2(6), ULK1(1), ULK2(3), ULK3(1) 2977990 32 21 32 17 18 0 3 8 3 0 0.660 1.000 1.000 545 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(1), DAB1(9), FYN(1), RELN(16), VLDLR(1) 2003659 28 21 28 17 18 3 1 4 2 0 0.832 1.000 1.000 546 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(6), AXIN1(3), CREBBP(4), CSNK1A1(1), CTNNB1(6), FZD1(2), GSK3B(1), HDAC1(1), NLK(1), TLE1(2), WNT1(1) 4159683 28 21 28 13 11 2 2 7 6 0 0.721 1.000 1.000 547 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(6), ATM(6), BRCA1(2), CDKN1A(1), CHEK1(1), CHEK2(1), JUN(1), MDM2(2), MRE11A(1), NFKB1(1), NFKBIA(1), RAD50(2), RBBP8(1), RELA(2), TP73(1) 4122227 29 20 29 15 9 5 1 11 3 0 0.893 1.000 1.000 548 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(1), ACOT11(1), DHRS1(1), DHRS2(3), DHRS3(2), DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(1), GCDH(3), HADHA(4), MYST3(3), MYST4(2), PNPLA3(1), SH3GLB1(1) 3719272 27 20 27 15 15 5 0 7 0 0 0.753 1.000 1.000 549 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 GBA3(4), LPO(5), MPO(4), PRDX6(1), TPO(12) 1193436 26 20 26 17 21 2 0 1 2 0 0.557 1.000 1.000 550 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(2), POLR1B(1), POLR2A(4), POLR2B(4), POLR2C(1), POLR2D(1), POLR2H(2), POLR3B(7), POLR3H(1) 3351636 23 20 23 13 9 4 4 5 1 0 0.760 1.000 1.000 551 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CXCR3(1), ETV5(1), IFNG(1), IL12RB1(3), IL18R1(4), JAK2(2), JUN(1), MAP2K6(1), MAPK14(2), STAT4(9), TYK2(1) 2643527 26 20 25 14 13 0 1 4 8 0 0.736 1.000 1.000 552 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(1), IKBKB(3), IL1A(1), IL1R1(2), IRAK1(3), MAP3K1(1), NFKB1(1), NFKBIA(1), RELA(2), TLR4(6), TRAF6(1) 3423556 22 20 22 14 15 3 1 3 0 0 0.782 1.000 1.000 553 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD2(6), CD4(5), CXCR3(1), IFNG(1), IL12RB1(3), JAK2(2), STAT4(9), TYK2(1) 2071805 28 20 26 13 18 1 1 2 6 0 0.377 1.000 1.000 554 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(3), CHUK(1), IKBKB(3), JUN(1), MAP2K3(4), MAP2K4(1), MAP2K6(1), MAP3K1(1), MAP4K2(2), MAPK14(2), NFKB1(1), NFKBIA(1), RELA(2) 3387475 23 20 23 13 8 6 2 6 1 0 0.726 1.000 1.000 555 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 IFNG(1), IFNGR1(1), IFNGR2(2), IKBKB(3), JAK2(2), LIN7A(4), NFKB1(1), NFKBIA(1), RB1(2), RELA(2), USH1C(6) 2464818 25 20 25 12 12 2 1 4 5 1 0.644 1.000 1.000 556 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(3), GRB2(1), MAPK1(1), MAPK7(1), MEF2A(1), MEF2D(1), NTRK1(5), PIK3CA(3), PIK3R1(3), PLCG1(6), RPS6KA1(1) 2686765 26 19 26 17 14 3 1 4 3 1 0.836 1.000 1.000 557 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(2), ASPH(1), COPS5(2), EDN1(3), EP300(1), EPO(2), HIF1A(3), JUN(1), LDHA(1), NOS3(6), P4HB(1), VHL(1) 2445862 24 19 23 10 14 0 2 5 3 0 0.599 1.000 1.000 558 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(6), CPT1A(3), LEP(1), LEPR(4), PRKAA2(6), PRKAB1(1), PRKAG1(1), PRKAG2(3) 2082070 25 19 25 16 15 2 2 3 3 0 0.866 1.000 1.000 559 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(3), GLB1(2), HEXB(1), LCT(6), MAN2C1(2), MANBA(2), NEU1(3), NEU2(3), NEU3(1), NEU4(4) 2339652 27 19 27 14 14 3 1 6 3 0 0.638 1.000 1.000 560 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(1), CNR2(1), DNMT1(6), MTNR1A(1), MTNR1B(2), PTAFR(1), PTGDR(3), PTGER2(2), PTGFR(1), PTGIR(1) 1585926 19 19 19 21 10 2 0 2 5 0 0.888 1.000 1.000 561 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(3), BIRC3(3), CASP3(1), CASP8(4), JUN(1), MAP2K4(1), MAP3K3(2), NFKB1(1), NFKB2(2), NFKBIA(1), NFKBIL1(2), NFKBIL2(2) 3842442 23 19 23 19 7 1 6 9 0 0 0.980 1.000 1.000 562 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), GCK(5), GFPT1(2), GNE(1), HEXB(1), HK1(2), HK2(4), HK3(3), RENBP(2), UAP1(1) 2414600 22 18 22 10 12 0 1 3 6 0 0.411 1.000 1.000 563 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(1), LPO(5), MPO(4), PRDX6(1), SHMT1(1), TPO(12) 1662810 25 18 25 21 20 2 0 2 1 0 0.843 1.000 1.000 564 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(2), IL22RA1(4), JAK1(2), JAK2(2), JAK3(1), SOCS3(1), STAT3(6), STAT5A(1), STAT5B(1), TYK2(1) 2589870 21 18 21 14 8 3 2 5 3 0 0.878 1.000 1.000 565 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), CAT(1), LPO(5), MPO(4), PRDX6(1), SHMT1(1), TPO(12) 1683278 25 18 25 20 20 2 0 2 1 0 0.817 1.000 1.000 566 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(5), ENPP1(4), ENPP3(4), NMNAT2(1), NNMT(1), NT5E(1), QPRT(2) 2083066 18 18 18 12 9 2 1 5 1 0 0.874 1.000 1.000 567 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(9), AKT1(3), ATM(6), CDKN1A(1), CSNK1A1(1), HIC1(1), HIF1A(3), MDM2(2), NQO1(1) 2854013 27 18 26 14 13 2 1 7 4 0 0.786 1.000 1.000 568 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(1), APC(6), AXIN1(3), CTNNB1(6), FZD1(2), GSK3B(1), NOTCH1(1), PSEN1(1), WNT1(1) 3000580 22 18 22 13 12 2 1 2 5 0 0.782 1.000 1.000 569 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 20 AKT1(3), CCNE1(1), CDK6(1), CDKN1A(1), MAPK1(1), NFKB1(1), NFKBIA(1), PAK1(2), PIK3CA(3), PIK3R1(3), RAF1(3), RB1(2), RELA(2) 2718190 24 18 24 12 9 1 3 7 2 2 0.713 1.000 1.000 570 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(1), CREBBP(4), EP300(1), NCOA3(4), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RARA(2) 2948181 22 17 22 12 11 0 0 7 4 0 0.839 1.000 1.000 571 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(3), ACO2(1), CS(1), IDH1(3), IDH2(1), IDH3G(1), MDH2(1), PC(7), PCK1(3), SDHB(1), SUCLG2(1) 2956519 23 17 21 11 14 0 2 5 2 0 0.518 1.000 1.000 572 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD80(3), CD86(3), GRB2(1), HLA-DRA(3), HLA-DRB1(1), ICOS(1), ITK(2), LCK(1), PIK3CA(3), PIK3R1(3), PTPN11(2) 1824512 23 17 23 10 9 1 0 11 1 1 0.805 1.000 1.000 573 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(2), EPHB1(3), FYN(1), ITGA1(3), ITGB1(1), L1CAM(2), LYN(2), SELP(11) 2251383 25 17 23 19 17 2 1 4 1 0 0.908 1.000 1.000 574 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(6), CDH1(3), CREBBP(4), EP300(1), MAP2K1(3), SKIL(2), TGFB3(2), TGFBR2(2) 3673213 23 17 21 13 10 3 0 5 5 0 0.882 1.000 1.000 575 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM2(1), CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), SYT1(8) 1655920 21 16 20 16 13 4 1 1 2 0 0.788 1.000 1.000 576 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GALNS(1), GLB1(2), GNS(1), GUSB(3), HEXB(1), IDS(4), LCT(6), NAGLU(2) 2034538 21 16 21 12 17 0 0 2 2 0 0.606 1.000 1.000 577 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 RPL11(1), RPL18(1), RPL21(1), RPL27(2), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL36AL(1), RPL38(1), RPL3L(1), RPS11(1), RPS16(1), RPS23(1), RPS7(3), RPS8(1) 3203960 20 16 20 15 7 1 4 5 3 0 0.932 1.000 1.000 578 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), DDOST(1), DPAGT1(1), FUT8(2), MAN1A1(5), MGAT1(1), MGAT3(2), MGAT4A(3), MGAT4B(1), ST6GAL1(1) 2845499 22 16 22 12 15 2 0 1 4 0 0.536 1.000 1.000 579 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 13 GALNT1(1), GALNT10(5), GALNT2(1), GALNT6(2), GALNT7(2), GALNT8(5), GALNT9(2), GCNT1(3), ST3GAL2(1) 1893998 22 16 21 11 15 0 1 2 4 0 0.514 1.000 1.000 580 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(6), CDC25A(1), CHEK1(1), MYT1(7), RB1(2) 2307496 17 16 17 10 9 2 0 3 2 1 0.814 1.000 1.000 581 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), IL6R(1), JAK1(2), JAK2(2), JAK3(1), PIAS3(2), PTPRU(2), REG1A(2), STAT3(6) 2161683 20 16 20 11 9 2 0 6 3 0 0.752 1.000 1.000 582 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 15 ACTN1(1), ACTN2(4), CAPN1(2), ITGA1(3), ITGB1(1), ITGB3(3), PTK2(2), PXN(1), SPTAN1(2), TLN1(2) 3947211 21 16 21 15 10 4 2 4 1 0 0.772 1.000 1.000 583 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 CASP8(4), MAP2K1(3), MAP2K4(1), MAP3K1(1), MAPK1(1), NFKB1(1), NSMAF(1), RAF1(3), RELA(2), SMPD1(2) 2906926 19 15 17 10 8 1 3 5 2 0 0.704 1.000 1.000 584 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(2), B3GNT2(1), B3GNT7(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), B4GALT4(1), CHST1(1), CHST4(3), CHST6(1), FUT8(2), ST3GAL2(1), ST3GAL3(1) 1770269 17 15 16 10 14 1 1 0 1 0 0.505 1.000 1.000 585 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(3), AMT(1), ATIC(2), FTCD(1), GART(2), MTHFD1(3), MTR(4), SHMT1(1), TYMS(1) 2699315 18 15 18 13 10 0 2 4 2 0 0.895 1.000 1.000 586 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(1), CLOCK(1), CRY1(1), CRY2(1), CSNK1E(1), NPAS2(1), PER1(2), PER2(5), PER3(4) 2425068 17 15 16 12 13 2 0 0 2 0 0.814 1.000 1.000 587 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(2), GLB1(2), HEXB(1), LCT(6), SLC33A1(2), ST3GAL2(1), ST6GALNAC5(3), ST8SIA1(1) 2345361 18 14 18 10 13 1 1 1 2 0 0.540 1.000 1.000 588 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(6), CYP2C9(10) 289574 16 14 15 12 12 2 0 0 2 0 0.762 1.000 1.000 589 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(3), AMT(1), ATIC(2), GART(2), MTHFD1(3), MTR(4), SHMT1(1), TYMS(1) 2548429 17 14 17 10 9 0 2 4 2 0 0.736 1.000 1.000 590 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGEF2(3), COPA(1), GBF1(3), GPLD1(7), KDELR3(1) 2335989 15 13 15 11 5 0 2 7 1 0 0.914 1.000 1.000 591 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), IKBKAP(2), IKBKB(3), MAP3K1(1), NFKB1(1), NFKBIA(1), RELA(2), TRAF3(2), TRAF6(1) 2576906 14 13 14 8 8 3 1 2 0 0 0.714 1.000 1.000 592 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(1), JUN(1), OPRK1(5), POLR2A(4), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1) 1829534 21 13 21 13 14 0 1 3 3 0 0.647 1.000 1.000 593 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(1), EGF(3), EGFR(4), HGS(1), RAB5A(1), TF(3), TFRC(3) 1832484 16 13 16 10 7 2 2 4 1 0 0.864 1.000 1.000 594 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADM(1), ACSL1(1), CPT1A(3), DCI(1), EHHADH(2), HADHA(4), SLC25A20(1) 2420805 13 13 13 10 5 2 1 3 2 0 0.926 1.000 1.000 595 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(1), IKBKAP(2), IKBKB(3), MAP3K1(1), NFKB1(1), NFKBIA(1), RELA(2), TRAF1(1), TRAF3(2) 3178319 14 13 14 11 8 3 1 2 0 0 0.890 1.000 1.000 596 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6V0A1(3), ATP6V0A4(4), ATP6V1B1(3), ATP6V1C2(2), ATP6V1G3(1), SHMT1(1) 2148973 15 12 15 11 8 0 2 5 0 0 0.864 1.000 1.000 597 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(2), LCT(6), PGM1(3), PYGL(1), PYGM(1), TREH(1) 1877938 14 12 14 10 12 0 1 0 1 0 0.555 1.000 1.000 598 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6V0A1(3), ATP6V0A4(4), ATP6V1B1(3), ATP6V1C2(2), ATP6V1G3(1), SHMT1(1) 2148973 15 12 15 11 8 0 2 5 0 0 0.864 1.000 1.000 599 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(1), ATP6V0A1(3), ATP6V0A4(4), ATP6V1B1(3), ATP6V1C2(2), ATP6V1G3(1), FDXR(1), SHMT1(1) 2285523 16 12 16 12 8 0 2 5 1 0 0.877 1.000 1.000 600 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(6), ATR(6), CHEK1(1), CHEK2(1) 2172171 14 12 14 10 7 1 1 4 1 0 0.943 1.000 1.000 601 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(4), DAXX(1), PAX3(1), PML(1), RARA(2), RB1(2), SP100(3) 2564192 14 12 14 10 4 2 0 7 0 1 0.920 1.000 1.000 602 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6V0A1(3), ATP6V0A4(4), ATP6V1B1(3), ATP6V1C2(2), ATP6V1G3(1), SHMT1(1) 2148973 15 12 15 11 8 0 2 5 0 0 0.864 1.000 1.000 603 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(2), AOC2(4), AOC3(2), CES1(3) 858422 11 11 11 9 10 0 0 1 0 0 0.816 1.000 1.000 604 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS2(3), DHRS3(2), DHRS7(1), ESCO1(1), MYST3(3), MYST4(2), PNPLA3(1), SH3GLB1(1) 2375914 15 11 15 10 8 3 0 4 0 0 0.869 1.000 1.000 605 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(1), HDAC9(7), MEF2A(1), MEF2D(1) 1067375 12 11 12 10 10 1 0 0 1 0 0.876 1.000 1.000 606 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(1), CREBBP(4), EP300(1), IKBKB(3), NFKB1(1), NFKBIA(1), RELA(2), TRAF6(1) 3177702 14 11 14 10 3 3 1 6 1 0 0.945 1.000 1.000 607 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGAP5(3), CASP10(1), CASP3(1), CASP8(4), GZMB(1), JUN(1) 1844690 12 10 12 7 6 0 1 5 0 0 0.856 1.000 1.000 608 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 11 ALAD(1), ALAS1(1), ALAS2(3), CPO(1), HBB(2) 1090247 8 8 8 10 6 0 0 1 1 0 0.971 1.000 1.000 609 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAT2(1), ECHS1(1), EHHADH(2), HADHA(4) 1192029 8 7 8 6 4 2 0 2 0 0 0.899 1.000 1.000 610 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(5) 696182 5 5 5 6 3 0 1 1 0 0 0.948 1.000 1.000 611 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 HGD(4) 320770 4 4 4 6 2 1 1 0 0 0 0.961 1.000 1.000 612 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ARG1(1), GLS(1), PRODH(1) 775098 3 3 3 5 0 1 1 1 0 0 0.979 1.000 1.000 613 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(1), APOBEC2(1), APOBEC3F(1) 1055352 3 3 3 8 2 1 0 0 0 0 0.997 1.000 1.000 614 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(1), NOTCH1(1), PSEN1(1) 1304185 3 3 3 5 3 0 0 0 0 0 0.943 1.000 1.000 615 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(1) 895698 1 1 1 3 0 0 1 0 0 0 0.997 1.000 1.000 616 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 161310 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000