E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.11 0.193 -9999.0 0.0 -0.382 33.0 33.0 KLHL20 -0.025 0.078 -9999.0 0.0 -0.193 3.0 3.0 CYFIP2 -0.008 0.092 -9999.0 0.0 -0.409 5.0 5.0 Rac1/GDP -0.046 0.119 -9999.0 0.0 -0.211 32.0 32.0 ENAH -0.114 0.196 -9999.0 0.0 -0.387 33.0 33.0 AP1M1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.01 0.029 -9999.0 0.0 -0.276 1.0 1.0 RAP1A 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.048 0.062 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.035 0.042 -9999.0 0.0 -0.137 5.0 5.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.057 0.12 -9999.0 0.0 -0.213 34.0 34.0 RAPGEF1 -0.087 0.171 -9999.0 0.0 -0.327 33.0 33.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.118 0.198 -9999.0 0.0 -0.397 33.0 33.0 CRK -0.099 0.183 -9999.0 0.0 -0.356 33.0 33.0 E-cadherin/gamma catenin/alpha catenin -0.07 0.126 -9999.0 0.0 -0.235 34.0 34.0 alphaE/beta7 Integrin 0.01 0.051 -9999.0 0.0 -0.281 3.0 3.0 IQGAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.019 0.036 -9999.0 0.0 -0.206 2.0 2.0 DLG1 -0.11 0.193 -9999.0 0.0 -0.382 33.0 33.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.036 0.046 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.005 0.059 -9999.0 0.0 -0.409 2.0 2.0 ARF6/GTP/NME1/Tiam1 0.009 0.059 -9999.0 0.0 -0.206 7.0 7.0 PI3K -0.045 0.057 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.094 0.147 -9999.0 0.0 -0.276 38.0 38.0 TIAM1 -0.017 0.108 -9999.0 0.0 -0.409 7.0 7.0 E-cadherin(dimer)/Ca2+ -0.047 0.103 -9999.0 0.0 -0.188 33.0 33.0 AKT1 -0.026 0.034 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.009 0.042 -9999.0 0.0 -0.409 1.0 1.0 CDH1 -0.139 0.199 -9999.0 0.0 -0.395 37.0 37.0 RhoA/GDP -0.046 0.119 -9999.0 0.0 -0.211 32.0 32.0 actin cytoskeleton organization -0.017 0.06 -9999.0 0.0 -0.142 3.0 3.0 CDC42/GDP -0.046 0.119 -9999.0 0.0 -0.211 32.0 32.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.061 0.109 -9999.0 0.0 -0.208 34.0 34.0 ITGB7 0.0 0.072 -9999.0 0.0 -0.409 3.0 3.0 RAC1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.05 0.11 -9999.0 0.0 -0.201 33.0 33.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.054 0.102 -9999.0 0.0 -0.193 33.0 33.0 mol:GDP -0.06 0.133 -9999.0 0.0 -0.244 33.0 33.0 CDC42/GTP/IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.005 0.059 -9999.0 0.0 -0.409 2.0 2.0 p120 catenin/RhoA/GDP -0.047 0.12 -9999.0 0.0 -0.214 32.0 32.0 RAC1/GTP/IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.009 0.044 -9999.0 0.0 -0.177 1.0 1.0 NME1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.112 0.192 -9999.0 0.0 -0.382 33.0 33.0 regulation of cell-cell adhesion -0.043 0.056 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.018 0.023 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.031 0.09 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.051 0.118 -9999.0 0.0 -0.2 35.0 35.0 CCND1 -0.012 0.052 -9999.0 0.0 -0.218 1.0 1.0 VAV2 -0.107 0.196 -9999.0 0.0 -0.366 35.0 35.0 RAP1/GDP -0.037 0.099 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.108 0.187 -9999.0 0.0 -0.371 33.0 33.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.045 0.113 -9999.0 0.0 -0.363 3.0 3.0 E-cadherin/beta catenin -0.096 0.146 -9999.0 0.0 -0.301 33.0 33.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.11 0.193 -9999.0 0.0 -0.381 33.0 33.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.072 0.091 -9999.0 0.0 -0.309 3.0 3.0 E-cadherin/beta catenin/alpha catenin -0.065 0.12 -9999.0 0.0 -0.229 33.0 33.0 ITGAE 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.121 0.202 -9999.0 0.0 -0.405 33.0 33.0