Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.011 0.136 -9999.0 0.0 -0.48 5.0 5.0 IHH 0.004 0.047 -9999.0 0.0 -0.311 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.004 0.061 -9999.0 0.0 -0.21 6.0 6.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.005 0.06 0.209 6.0 -9999.0 0.0 6.0 SMO/beta Arrestin2 -0.012 0.136 -9999.0 0.0 -0.493 5.0 5.0 SMO -0.02 0.142 -9999.0 0.0 -0.523 5.0 5.0 AKT1 0.007 0.07 -9999.0 0.0 -0.266 1.0 1.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.016 0.099 -9999.0 0.0 -0.343 8.0 8.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.019 0.14 -9999.0 0.0 -0.514 5.0 5.0 STIL -0.008 0.099 -9999.0 0.0 -0.334 5.0 5.0 DHH N/PTCH2 -0.016 0.082 -9999.0 0.0 -0.198 16.0 16.0 DHH N/PTCH1 -0.017 0.116 -9999.0 0.0 -0.315 8.0 8.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.032 0.113 -9999.0 0.0 -0.305 14.0 14.0 PTHLH -0.016 0.16 -9999.0 0.0 -0.592 5.0 5.0 determination of left/right symmetry -0.019 0.14 -9999.0 0.0 -0.514 5.0 5.0 PIK3R1 0.009 0.042 -9999.0 0.0 -0.409 1.0 1.0 skeletal system development -0.016 0.159 -9999.0 0.0 -0.587 5.0 5.0 IHH N/Hhip 0.002 0.05 -9999.0 0.0 -0.2 5.0 5.0 DHH N/Hhip -0.022 0.092 -9999.0 0.0 -0.219 16.0 16.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.019 0.14 -9999.0 0.0 -0.514 5.0 5.0 pancreas development -0.003 0.056 -9999.0 0.0 -0.276 4.0 4.0 HHAT -0.008 0.092 -9999.0 0.0 -0.409 5.0 5.0 PI3K 0.017 0.03 -9999.0 0.0 -0.281 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.009 0.042 -9999.0 0.0 -0.409 1.0 1.0 somite specification -0.019 0.14 -9999.0 0.0 -0.514 5.0 5.0 SHH Np/Cholesterol/PTCH1 -0.01 0.103 -9999.0 0.0 -0.355 5.0 5.0 SHH Np/Cholesterol/PTCH2 -0.005 0.06 -9999.0 0.0 -0.211 5.0 5.0 SHH Np/Cholesterol/Megalin -0.106 0.117 -9999.0 0.0 -0.255 27.0 27.0 SHH -0.014 0.076 -9999.0 0.0 -0.233 10.0 10.0 catabolic process -0.002 0.103 -9999.0 0.0 -0.398 4.0 4.0 SMO/Vitamin D3 -0.015 0.124 -9999.0 0.0 -0.419 6.0 6.0 SHH Np/Cholesterol/Hhip -0.011 0.066 -9999.0 0.0 -0.238 5.0 5.0 LRP2 -0.189 0.18 -9999.0 0.0 -0.337 57.0 57.0 receptor-mediated endocytosis -0.084 0.159 -9999.0 0.0 -0.472 9.0 9.0 SHH Np/Cholesterol/BOC -0.017 0.088 -9999.0 0.0 -0.288 7.0 7.0 SHH Np/Cholesterol/CDO -0.007 0.071 -9999.0 0.0 -0.245 6.0 6.0 mesenchymal cell differentiation 0.011 0.066 0.237 5.0 -9999.0 0.0 5.0 mol:Vitamin D3 -0.008 0.104 -9999.0 0.0 -0.356 5.0 5.0 IHH N/PTCH2 0.01 0.042 -9999.0 0.0 -0.202 3.0 3.0 CDON 0.005 0.059 -9999.0 0.0 -0.409 2.0 2.0 IHH N/PTCH1 0.0 0.105 -9999.0 0.0 -0.4 4.0 4.0 Megalin/LRPAP1 -0.121 0.127 -9999.0 0.0 -0.225 57.0 57.0 PTCH2 0.007 0.041 -9999.0 0.0 -0.276 2.0 2.0 SHH Np/Cholesterol -0.009 0.057 -9999.0 0.0 -0.173 10.0 10.0 PTCH1 -0.002 0.104 -9999.0 0.0 -0.399 4.0 4.0 HHIP -0.003 0.056 -9999.0 0.0 -0.276 4.0 4.0