Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.051 0.103 -9999.0 0.0 -0.194 33.0 33.0 epithelial cell differentiation -0.049 0.101 -9999.0 0.0 -0.186 33.0 33.0 CYFIP2 -0.008 0.092 -9999.0 0.0 -0.409 5.0 5.0 ENAH -0.018 0.078 -9999.0 0.0 -0.21 3.0 3.0 EGFR -0.009 0.08 -9999.0 0.0 -0.295 7.0 7.0 EPHA2 0.003 0.058 -9999.0 0.0 -0.321 3.0 3.0 MYO6 -0.052 0.099 -9999.0 0.0 -0.177 37.0 37.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.014 0.056 -9999.0 0.0 -0.229 5.0 5.0 AQP5 -0.048 0.092 -9999.0 0.0 -0.226 8.0 8.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.044 0.093 -9999.0 0.0 -0.171 33.0 33.0 regulation of calcium-dependent cell-cell adhesion -0.058 0.109 -9999.0 0.0 -0.194 35.0 35.0 EGF -0.085 0.167 -9999.0 0.0 -0.358 26.0 26.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.048 0.132 -9999.0 0.0 -0.528 4.0 4.0 cortical microtubule organization -0.049 0.101 -9999.0 0.0 -0.186 33.0 33.0 GO:0000145 -0.043 0.088 -9999.0 0.0 -0.163 33.0 33.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.047 0.103 -9999.0 0.0 -0.188 33.0 33.0 MLLT4 0.005 0.059 -9999.0 0.0 -0.409 2.0 2.0 ARF6/GDP -0.052 0.069 -9999.0 0.0 -0.245 2.0 2.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.028 0.032 -9999.0 0.0 -0.201 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.037 0.091 -9999.0 0.0 -0.212 2.0 2.0 PVRL2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.047 0.099 -9999.0 0.0 -0.181 33.0 33.0 ARF6/GTP 0.032 0.029 -9999.0 0.0 -0.181 1.0 1.0 CDH1 -0.139 0.199 -9999.0 0.0 -0.395 37.0 37.0 EGFR/EGFR/EGF/EGF -0.105 0.112 -9999.0 0.0 -0.328 13.0 13.0 RhoA/GDP -0.043 0.094 -9999.0 0.0 -0.172 33.0 33.0 actin cytoskeleton organization -0.048 0.097 -9999.0 0.0 -0.267 1.0 1.0 IGF-1R heterotetramer 0.009 0.042 -9999.0 0.0 -0.409 1.0 1.0 GIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.009 0.042 -9999.0 0.0 -0.409 1.0 1.0 IGF1 -0.028 0.124 -9999.0 0.0 -0.396 10.0 10.0 DIAPH1 -0.022 0.125 -9999.0 0.0 -0.561 5.0 5.0 Wnt receptor signaling pathway 0.049 0.101 0.186 33.0 -9999.0 0.0 33.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.052 0.069 -9999.0 0.0 -0.245 2.0 2.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.049 0.099 -9999.0 0.0 -0.273 1.0 1.0 EFNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.042 0.091 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.062 0.082 -9999.0 0.0 -0.282 2.0 2.0 SEC6/SEC8 -0.055 0.069 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.059 0.11 -9999.0 0.0 -0.196 35.0 35.0 HGF/MET -0.097 0.115 -9999.0 0.0 -0.314 15.0 15.0 HGF -0.024 0.108 -9999.0 0.0 -0.325 11.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.052 0.103 -9999.0 0.0 -0.196 33.0 33.0 actin cable formation -0.009 0.079 -9999.0 0.0 -0.316 1.0 1.0 KIAA1543 -0.074 0.112 -9999.0 0.0 -0.293 10.0 10.0 KIFC3 -0.044 0.095 -9999.0 0.0 -0.173 33.0 33.0 NCK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.048 0.096 -9999.0 0.0 -0.173 35.0 35.0 NCK1/GIT1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.049 0.101 -9999.0 0.0 -0.186 33.0 33.0 EXOC4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.044 0.095 -9999.0 0.0 -0.173 33.0 33.0 PIP5K1C -0.044 0.095 -9999.0 0.0 -0.173 33.0 33.0 LIMA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.023 0.082 -9999.0 0.0 -0.216 2.0 2.0 adherens junction assembly -0.058 0.11 -9999.0 0.0 -0.335 4.0 4.0 IGF-1R heterotetramer/IGF1 -0.077 0.097 -9999.0 0.0 -0.337 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.013 0.042 -9999.0 0.0 -0.281 2.0 2.0 MET -0.047 0.14 -9999.0 0.0 -0.359 16.0 16.0 PLEKHA7 -0.055 0.103 -9999.0 0.0 -0.183 36.0 36.0 mol:GTP 0.027 0.031 -9999.0 0.0 -0.2 1.0 1.0 establishment of epithelial cell apical/basal polarity -0.025 0.086 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.051 0.103 -9999.0 0.0 -0.194 33.0 33.0 regulation of cell-cell adhesion -0.048 0.097 -9999.0 0.0 -0.267 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.052 0.103 -9999.0 0.0 -0.196 33.0 33.0