E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.124 0.196 -9999.0 0.0 -0.374 37.0 37.0 KLHL20 -0.033 0.104 0.191 4.0 -0.222 11.0 15.0 CYFIP2 0.016 0.061 -9999.0 0.0 -0.329 3.0 3.0 Rac1/GDP -0.054 0.116 -9999.0 0.0 -0.231 23.0 23.0 ENAH -0.122 0.193 -9999.0 0.0 -0.365 37.0 37.0 AP1M1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.027 0.089 -9999.0 0.0 -0.157 26.0 26.0 ABI1/Sra1/Nap1 -0.045 0.055 -9999.0 0.0 -0.145 13.0 13.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.017 0.122 -9999.0 0.0 -0.188 32.0 32.0 RAPGEF1 -0.096 0.175 -9999.0 0.0 -0.334 32.0 32.0 CTNND1 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.12 0.204 -9999.0 0.0 -0.381 37.0 37.0 CRK -0.102 0.187 0.194 1.0 -0.355 33.0 34.0 E-cadherin/gamma catenin/alpha catenin -0.028 0.12 -9999.0 0.0 -0.199 32.0 32.0 alphaE/beta7 Integrin 0.032 0.047 -9999.0 0.0 -0.23 3.0 3.0 IQGAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.041 0.036 -9999.0 0.0 -0.163 2.0 2.0 DLG1 -0.119 0.194 -9999.0 0.0 -0.372 36.0 36.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.046 0.049 -9999.0 0.0 -0.122 25.0 25.0 MLLT4 0.018 0.051 -9999.0 0.0 -0.329 2.0 2.0 ARF6/GTP/NME1/Tiam1 0.035 0.059 -9999.0 0.0 -0.175 7.0 7.0 PI3K -0.057 0.062 -9999.0 0.0 -0.154 25.0 25.0 ARF6 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.049 0.131 -9999.0 0.0 -0.236 32.0 32.0 TIAM1 0.002 0.091 -9999.0 0.0 -0.329 7.0 7.0 E-cadherin(dimer)/Ca2+ -0.011 0.109 -9999.0 0.0 -0.166 32.0 32.0 AKT1 -0.027 0.05 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.024 0.036 -9999.0 0.0 -0.329 1.0 1.0 CDH1 -0.086 0.168 -9999.0 0.0 -0.329 32.0 32.0 RhoA/GDP -0.055 0.131 -9999.0 0.0 -0.231 29.0 29.0 actin cytoskeleton organization -0.021 0.082 0.162 5.0 -0.162 11.0 16.0 CDC42/GDP -0.056 0.13 -9999.0 0.0 -0.231 29.0 29.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.05 0.101 -9999.0 0.0 -0.193 32.0 32.0 ITGB7 0.018 0.061 -9999.0 0.0 -0.329 3.0 3.0 RAC1 0.023 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.011 0.117 -9999.0 0.0 -0.178 32.0 32.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.02 0.099 -9999.0 0.0 -0.162 32.0 32.0 mol:GDP -0.074 0.139 -9999.0 0.0 -0.261 29.0 29.0 CDC42/GTP/IQGAP1 0.036 0.01 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.024 0.036 -9999.0 0.0 -0.329 1.0 1.0 p120 catenin/RhoA/GDP -0.05 0.137 -9999.0 0.0 -0.236 28.0 28.0 RAC1/GTP/IQGAP1 0.03 0.016 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.042 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.014 0.058 0.122 5.0 -0.105 12.0 17.0 NME1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.122 0.196 -9999.0 0.0 -0.378 36.0 36.0 regulation of cell-cell adhesion -0.033 0.07 -9999.0 0.0 -0.141 26.0 26.0 WASF2 -0.015 0.043 0.093 3.0 -0.085 8.0 11.0 Rap1/GTP -0.029 0.098 0.162 6.0 -0.171 26.0 32.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.008 0.126 -9999.0 0.0 -0.184 32.0 32.0 CCND1 -0.018 0.068 0.14 5.0 -0.127 12.0 17.0 VAV2 -0.145 0.257 -9999.0 0.0 -0.441 37.0 37.0 RAP1/GDP -0.036 0.11 0.179 2.0 -0.189 27.0 29.0 adherens junction assembly -0.119 0.19 -9999.0 0.0 -0.367 36.0 36.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.021 0.113 -9999.0 0.0 -0.179 32.0 32.0 E-cadherin/beta catenin -0.084 0.136 -9999.0 0.0 -0.281 32.0 32.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.118 0.188 -9999.0 0.0 -0.357 37.0 37.0 PIK3CA 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.086 0.128 -9999.0 0.0 -0.346 12.0 12.0 E-cadherin/beta catenin/alpha catenin -0.026 0.117 -9999.0 0.0 -0.194 32.0 32.0 ITGAE 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.123 0.208 -9999.0 0.0 -0.389 37.0 37.0