Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.045 0.098 -9999.0 0.0 -0.184 32.0 32.0 epithelial cell differentiation -0.014 0.105 -9999.0 0.0 -0.165 32.0 32.0 CYFIP2 0.016 0.061 -9999.0 0.0 -0.329 3.0 3.0 ENAH -0.056 0.061 -9999.0 0.0 -0.233 1.0 1.0 EGFR 0.022 0.039 -9999.0 0.0 -0.329 1.0 1.0 EPHA2 0.025 0.037 -9999.0 0.0 -0.329 1.0 1.0 MYO6 -0.066 0.071 -9999.0 0.0 -0.162 34.0 34.0 CTNNB1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.043 0.045 -9999.0 0.0 -0.187 3.0 3.0 AQP5 -0.032 0.067 -9999.0 0.0 -0.309 1.0 1.0 CTNND1 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.061 0.068 -9999.0 0.0 -0.16 31.0 31.0 regulation of calcium-dependent cell-cell adhesion -0.062 0.073 -9999.0 0.0 -0.164 31.0 31.0 EGF -0.026 0.134 -9999.0 0.0 -0.329 16.0 16.0 NCKAP1 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.053 0.093 -9999.0 0.0 -0.311 7.0 7.0 cortical microtubule organization -0.014 0.105 -9999.0 0.0 -0.165 32.0 32.0 GO:0000145 -0.059 0.065 -9999.0 0.0 -0.153 31.0 31.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.011 0.109 -9999.0 0.0 -0.166 32.0 32.0 MLLT4 0.018 0.051 -9999.0 0.0 -0.329 2.0 2.0 ARF6/GDP -0.065 0.062 -9999.0 0.0 -0.156 30.0 30.0 ARF6 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.063 0.034 -9999.0 0.0 -0.179 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.044 0.062 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.048 0.066 -9999.0 0.0 -0.162 24.0 24.0 ARF6/GTP 0.068 0.037 -9999.0 0.0 -0.169 1.0 1.0 CDH1 -0.086 0.168 -9999.0 0.0 -0.329 32.0 32.0 EGFR/EGFR/EGF/EGF -0.041 0.109 -9999.0 0.0 -0.172 38.0 38.0 RhoA/GDP -0.012 0.103 -9999.0 0.0 -0.16 32.0 32.0 actin cytoskeleton organization -0.068 0.071 -9999.0 0.0 -0.165 27.0 27.0 IGF-1R heterotetramer 0.024 0.036 -9999.0 0.0 -0.329 1.0 1.0 GIT1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.024 0.036 -9999.0 0.0 -0.329 1.0 1.0 IGF1 -0.004 0.103 -9999.0 0.0 -0.329 9.0 9.0 DIAPH1 -0.03 0.211 -9999.0 0.0 -0.559 10.0 10.0 Wnt receptor signaling pathway 0.014 0.105 0.165 32.0 -9999.0 0.0 32.0 RHOA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.066 0.062 -9999.0 0.0 -0.157 30.0 30.0 CTNNA1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.069 0.072 -9999.0 0.0 -0.168 27.0 27.0 EFNA1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.066 0.067 -9999.0 0.0 -0.159 2.0 2.0 Ephrin A1/EPHA2 -0.017 0.098 -9999.0 0.0 -0.159 31.0 31.0 SEC6/SEC8 -0.046 0.061 -9999.0 0.0 -0.157 22.0 22.0 MGAT3 -0.063 0.073 -9999.0 0.0 -0.166 31.0 31.0 HGF/MET -0.025 0.104 -9999.0 0.0 -0.186 26.0 26.0 HGF 0.013 0.062 -9999.0 0.0 -0.329 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.045 0.098 -9999.0 0.0 -0.185 32.0 32.0 actin cable formation -0.036 0.077 0.226 1.0 -0.259 3.0 4.0 KIAA1543 -0.065 0.069 -9999.0 0.0 -0.159 33.0 33.0 KIFC3 -0.063 0.068 -9999.0 0.0 -0.162 31.0 31.0 NCK1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.065 0.07 -9999.0 0.0 -0.162 33.0 33.0 NCK1/GIT1 0.04 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.014 0.105 -9999.0 0.0 -0.165 32.0 32.0 EXOC4 0.021 0.013 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.063 0.068 -9999.0 0.0 -0.162 31.0 31.0 PIP5K1C -0.062 0.069 -9999.0 0.0 -0.162 31.0 31.0 LIMA1 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.057 0.069 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.06 0.078 -9999.0 0.0 -0.279 3.0 3.0 IGF-1R heterotetramer/IGF1 -0.035 0.113 -9999.0 0.0 -0.174 37.0 37.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.032 0.04 -9999.0 0.0 -0.23 2.0 2.0 MET -0.002 0.091 -9999.0 0.0 -0.329 7.0 7.0 PLEKHA7 -0.066 0.074 -9999.0 0.0 -0.166 33.0 33.0 mol:GTP 0.061 0.033 -9999.0 0.0 -0.178 1.0 1.0 establishment of epithelial cell apical/basal polarity -0.004 0.116 0.235 7.0 -9999.0 0.0 7.0 cortical actin cytoskeleton stabilization -0.045 0.098 -9999.0 0.0 -0.184 32.0 32.0 regulation of cell-cell adhesion -0.068 0.071 -9999.0 0.0 -0.165 27.0 27.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.045 0.098 -9999.0 0.0 -0.185 32.0 32.0