Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	21.0	152.0	7.0	-0.055	0.0	1000.0	-1000.0	0.0	-1000.0
E-cadherin signaling events	19.0	97.0	5.0	-0.086	0.028	1000.0	-1000.0	0.012	-1000.0
Signaling events regulated by Ret tyrosine kinase	18.0	1478.0	82.0	-0.108	0.028	1000.0	-1000.0	-0.029	-1000.0
IL4-mediated signaling events	15.0	1428.0	91.0	-0.61	0.465	1000.0	-1000.0	-0.082	-1000.0
E-cadherin signaling in the nascent adherens junction	15.0	1211.0	76.0	-0.145	0.042	1000.0	-1000.0	-0.037	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	14.0	1108.0	74.0	-0.086	0.068	1000.0	-1000.0	-0.046	-1000.0
TCR signaling in naïve CD8+ T cells	13.0	1218.0	93.0	-0.243	0.278	1000.0	-1000.0	-0.032	-1000.0
Angiopoietin receptor Tie2-mediated signaling	13.0	1207.0	88.0	-0.223	0.041	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	13.0	1033.0	78.0	-0.182	0.061	1000.0	-1000.0	-0.043	-1000.0
IL23-mediated signaling events	12.0	758.0	60.0	-0.3	0.028	1000.0	-1000.0	-0.076	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	11.0	806.0	68.0	-0.276	0.073	1000.0	-1000.0	-0.056	-1000.0
BCR signaling pathway	11.0	1091.0	99.0	-0.128	0.039	1000.0	-1000.0	-0.044	-1000.0
E-cadherin signaling in keratinocytes	11.0	491.0	43.0	-0.086	0.031	1000.0	-1000.0	-0.017	-1000.0
Endothelins	10.0	969.0	96.0	-0.085	0.048	1000.0	-1000.0	-0.042	-1000.0
FAS signaling pathway (CD95)	10.0	506.0	47.0	-0.043	0.042	1000.0	-1000.0	-0.034	-1000.0
LPA receptor mediated events	10.0	1042.0	102.0	-0.077	0.03	1000.0	-1000.0	-0.058	-1000.0
Syndecan-1-mediated signaling events	9.0	306.0	34.0	-0.054	0.028	1000.0	-1000.0	-0.017	-1000.0
IL12-mediated signaling events	8.0	757.0	87.0	-0.183	0.052	1000.0	-1000.0	-0.044	-1000.0
Nectin adhesion pathway	8.0	524.0	63.0	-0.086	0.045	1000.0	-1000.0	-0.024	-1000.0
Integrins in angiogenesis	8.0	739.0	84.0	-0.108	0.058	1000.0	-1000.0	-0.027	-1000.0
Calcium signaling in the CD4+ TCR pathway	8.0	257.0	31.0	-0.098	0.028	1000.0	-1000.0	-0.035	-1000.0
Wnt signaling	8.0	56.0	7.0	-0.035	0.019	1000.0	-1000.0	-0.005	-1000.0
Osteopontin-mediated events	7.0	282.0	38.0	-0.066	0.028	1000.0	-1000.0	-0.025	-1000.0
Thromboxane A2 receptor signaling	7.0	802.0	105.0	-0.081	0.033	1000.0	-1000.0	-0.027	-1000.0
Arf6 signaling events	7.0	464.0	62.0	-0.031	0.063	1000.0	-1000.0	-0.027	-1000.0
Glypican 1 network	7.0	336.0	48.0	-0.042	0.044	1000.0	-1000.0	-0.023	-1000.0
IFN-gamma pathway	7.0	503.0	68.0	-0.044	0.036	1000.0	-1000.0	-0.036	-1000.0
Glucocorticoid receptor regulatory network	7.0	849.0	114.0	-0.246	0.131	1000.0	-1000.0	-0.04	-1000.0
Ceramide signaling pathway	7.0	574.0	76.0	-0.057	0.041	1000.0	-1000.0	-0.023	-1000.0
EPHB forward signaling	7.0	607.0	85.0	-0.062	0.066	1000.0	-1000.0	-0.041	-1000.0
IL27-mediated signaling events	7.0	362.0	51.0	-0.131	0.084	1000.0	-1000.0	-0.033	-1000.0
Class IB PI3K non-lipid kinase events	7.0	21.0	3.0	-0.003	0.003	1000.0	-1000.0	-0.015	-1000.0
Caspase cascade in apoptosis	6.0	488.0	74.0	-0.068	0.042	1000.0	-1000.0	-0.025	-1000.0
JNK signaling in the CD4+ TCR pathway	6.0	110.0	17.0	-0.097	0.041	1000.0	-1000.0	-0.029	-1000.0
Noncanonical Wnt signaling pathway	6.0	177.0	26.0	-0.048	0.027	1000.0	-1000.0	-0.021	-1000.0
BMP receptor signaling	6.0	525.0	81.0	-0.075	0.047	1000.0	-1000.0	-0.019	-1000.0
EPO signaling pathway	6.0	351.0	55.0	0.009	0.061	1000.0	-1000.0	-0.02	-1000.0
Fc-epsilon receptor I signaling in mast cells	6.0	618.0	97.0	-0.084	0.049	1000.0	-1000.0	-0.054	-1000.0
Ephrin B reverse signaling	6.0	302.0	48.0	-0.039	0.038	1000.0	-1000.0	-0.027	-1000.0
EGFR-dependent Endothelin signaling events	6.0	140.0	21.0	-0.036	0.041	1000.0	-1000.0	-0.029	-1000.0
Syndecan-2-mediated signaling events	5.0	364.0	69.0	-0.016	0.036	1000.0	-1000.0	-0.031	-1000.0
a4b1 and a4b7 Integrin signaling	5.0	27.0	5.0	0.004	0.02	1000.0	-1000.0	0.015	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	5.0	462.0	85.0	-0.019	0.068	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by PTP1B	5.0	425.0	76.0	-0.067	0.046	1000.0	-1000.0	-0.028	-1000.0
p75(NTR)-mediated signaling	5.0	717.0	125.0	-0.049	0.076	1000.0	-1000.0	-0.048	-1000.0
Reelin signaling pathway	5.0	318.0	56.0	-0.032	0.06	1000.0	-1000.0	-0.026	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	5.0	277.0	52.0	-0.036	0.057	1000.0	-1000.0	-0.019	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	76.0	15.0	-0.021	0.028	1000.0	-1000.0	-0.024	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	5.0	225.0	45.0	-0.049	0.06	1000.0	-1000.0	-0.03	-1000.0
Effects of Botulinum toxin	5.0	146.0	26.0	-0.038	0.043	1000.0	-1000.0	-0.009	-1000.0
Glypican 2 network	5.0	22.0	4.0	0.002	0.013	1000.0	-1000.0	0.013	-1000.0
Class I PI3K signaling events	5.0	371.0	73.0	-0.09	0.057	1000.0	-1000.0	-0.026	-1000.0
TCGA08_retinoblastoma	5.0	42.0	8.0	-0.006	0.039	1000.0	-1000.0	-0.003	-1000.0
Syndecan-4-mediated signaling events	5.0	382.0	67.0	-0.04	0.036	1000.0	-1000.0	-0.028	-1000.0
IGF1 pathway	5.0	288.0	57.0	-0.03	0.059	1000.0	-1000.0	-0.022	-1000.0
Plasma membrane estrogen receptor signaling	5.0	437.0	86.0	-0.078	0.074	1000.0	-1000.0	-0.039	-1000.0
S1P4 pathway	5.0	130.0	25.0	-0.014	0.034	1000.0	-1000.0	-0.015	-1000.0
LPA4-mediated signaling events	4.0	50.0	12.0	-0.044	0.0	1000.0	-1000.0	-0.016	-1000.0
ErbB2/ErbB3 signaling events	4.0	319.0	65.0	-0.075	0.041	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by the Hedgehog family	4.0	232.0	52.0	-0.051	0.044	1000.0	-1000.0	-0.027	-1000.0
HIF-1-alpha transcription factor network	4.0	354.0	76.0	-0.064	0.048	1000.0	-1000.0	-0.024	-1000.0
amb2 Integrin signaling	4.0	384.0	82.0	-0.043	0.047	1000.0	-1000.0	-0.022	-1000.0
IL2 signaling events mediated by PI3K	4.0	283.0	58.0	-0.122	0.039	1000.0	-1000.0	-0.032	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	4.0	550.0	120.0	-0.073	0.074	1000.0	-1000.0	-0.029	-1000.0
Visual signal transduction: Rods	4.0	220.0	52.0	-0.014	0.043	1000.0	-1000.0	-0.017	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	81.0	17.0	-0.027	0.052	1000.0	-1000.0	-0.017	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	478.0	136.0	-0.271	0.068	1000.0	-1000.0	-0.03	-1000.0
Coregulation of Androgen receptor activity	3.0	254.0	76.0	-0.081	0.049	1000.0	-1000.0	-0.019	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	3.0	203.0	54.0	-0.019	0.04	1000.0	-1000.0	-0.021	-1000.0
FOXA2 and FOXA3 transcription factor networks	3.0	149.0	46.0	-0.185	0.032	1000.0	-1000.0	-0.068	-1000.0
PDGFR-alpha signaling pathway	3.0	174.0	44.0	-0.02	0.054	1000.0	-1000.0	-0.024	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	3.0	120.0	37.0	-0.026	0.048	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by HDAC Class III	3.0	156.0	40.0	-0.06	0.047	1000.0	-1000.0	-0.033	-1000.0
TRAIL signaling pathway	3.0	189.0	48.0	-0.018	0.057	1000.0	-1000.0	-0.02	-1000.0
IL1-mediated signaling events	3.0	223.0	62.0	-0.031	0.075	1000.0	-1000.0	-0.023	-1000.0
S1P5 pathway	3.0	55.0	17.0	-0.007	0.032	1000.0	-1000.0	-0.005	-1000.0
ceramide signaling pathway	3.0	154.0	49.0	-0.016	0.041	1000.0	-1000.0	-0.028	-1000.0
Retinoic acid receptors-mediated signaling	3.0	202.0	58.0	-0.058	0.055	1000.0	-1000.0	-0.04	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	112.0	36.0	-0.038	0.048	1000.0	-1000.0	-0.029	-1000.0
Signaling mediated by p38-alpha and p38-beta	3.0	173.0	44.0	-0.036	0.053	1000.0	-1000.0	-0.012	-1000.0
Canonical Wnt signaling pathway	3.0	172.0	51.0	-0.025	0.078	1000.0	-1000.0	-0.03	-1000.0
Regulation of p38-alpha and p38-beta	3.0	202.0	54.0	-0.048	0.055	1000.0	-1000.0	-0.037	-1000.0
TCGA08_rtk_signaling	3.0	94.0	26.0	-0.031	0.08	1000.0	-1000.0	-0.007	-1000.0
IL2 signaling events mediated by STAT5	3.0	84.0	22.0	-0.023	0.029	1000.0	-1000.0	-0.023	-1000.0
S1P3 pathway	3.0	127.0	42.0	-0.02	0.044	1000.0	-1000.0	-0.02	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	3.0	114.0	33.0	-0.02	0.064	1000.0	-1000.0	-0.028	-1000.0
PDGFR-beta signaling pathway	3.0	345.0	97.0	-0.066	0.068	1000.0	-1000.0	-0.039	-1000.0
Regulation of Androgen receptor activity	3.0	269.0	70.0	-0.071	0.038	1000.0	-1000.0	-0.042	-1000.0
Aurora B signaling	3.0	206.0	67.0	-0.037	0.055	1000.0	-1000.0	-0.026	-1000.0
ErbB4 signaling events	2.0	159.0	69.0	-0.079	0.076	1000.0	-1000.0	-0.027	-1000.0
BARD1 signaling events	2.0	120.0	57.0	-0.048	0.065	1000.0	-1000.0	-0.035	-1000.0
PLK2 and PLK4 events	2.0	7.0	3.0	-0.02	-1000.0	1000.0	-1000.0	-0.02	-1000.0
Cellular roles of Anthrax toxin	2.0	111.0	39.0	-0.021	0.03	1000.0	-1000.0	-0.019	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	147.0	65.0	-0.023	0.062	1000.0	-1000.0	-0.028	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	164.0	61.0	-0.015	0.077	1000.0	-1000.0	-0.044	-1000.0
PLK1 signaling events	2.0	211.0	85.0	-0.012	0.045	1000.0	-1000.0	-0.022	-1000.0
mTOR signaling pathway	2.0	132.0	53.0	-0.02	0.039	1000.0	-1000.0	-0.017	-1000.0
Class I PI3K signaling events mediated by Akt	2.0	151.0	68.0	-0.047	0.051	1000.0	-1000.0	-0.019	-1000.0
HIF-2-alpha transcription factor network	2.0	107.0	43.0	-0.09	0.092	1000.0	-1000.0	-0.033	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	191.0	83.0	-0.034	0.052	1000.0	-1000.0	-0.015	-1000.0
TCGA08_p53	2.0	16.0	7.0	-0.005	0.027	1000.0	-1000.0	-0.011	-1000.0
FoxO family signaling	2.0	157.0	64.0	-0.148	0.053	1000.0	-1000.0	-0.048	-1000.0
Atypical NF-kappaB pathway	2.0	80.0	31.0	-0.012	0.036	1000.0	-1000.0	-0.018	-1000.0
Nongenotropic Androgen signaling	2.0	142.0	52.0	-0.035	0.044	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	266.0	125.0	-0.019	0.069	1000.0	-1000.0	-0.018	-1000.0
IL6-mediated signaling events	2.0	171.0	75.0	-0.068	0.089	1000.0	-1000.0	-0.04	-1000.0
Insulin Pathway	2.0	204.0	74.0	-0.078	0.076	1000.0	-1000.0	-0.032	-1000.0
FOXM1 transcription factor network	2.0	108.0	51.0	-0.006	0.061	1000.0	-1000.0	-0.091	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	1.0	57.0	34.0	-0.038	0.074	1000.0	-1000.0	-0.028	-1000.0
Canonical NF-kappaB pathway	1.0	49.0	39.0	-0.009	0.06	1000.0	-1000.0	-0.019	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	52.0	28.0	-0.01	0.051	1000.0	-1000.0	-0.018	-1000.0
Visual signal transduction: Cones	1.0	57.0	38.0	-0.016	0.046	1000.0	-1000.0	-0.019	-1000.0
Aurora A signaling	1.0	77.0	60.0	-0.034	0.059	1000.0	-1000.0	-0.02	-1000.0
Arf6 downstream pathway	1.0	62.0	43.0	-0.037	0.051	1000.0	-1000.0	-0.026	-1000.0
S1P1 pathway	1.0	69.0	36.0	-0.033	0.032	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by HDAC Class I	1.0	150.0	104.0	-0.055	0.062	1000.0	-1000.0	-0.036	-1000.0
Syndecan-3-mediated signaling events	1.0	43.0	35.0	-0.004	0.076	1000.0	-1000.0	-0.014	-1000.0
Regulation of Telomerase	1.0	195.0	102.0	-0.041	0.056	1000.0	-1000.0	-0.047	-1000.0
Rapid glucocorticoid signaling	1.0	31.0	20.0	-0.013	0.032	1000.0	-1000.0	-0.011	-1000.0
p38 MAPK signaling pathway	1.0	66.0	44.0	-0.034	0.049	1000.0	-1000.0	-0.015	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	6.0	23.0	0.006	0.055	1000.0	-1000.0	-0.012	-1000.0
Signaling events mediated by HDAC Class II	0.0	66.0	75.0	-0.03	0.074	1000.0	-1000.0	-0.021	-1000.0
Circadian rhythm pathway	0.0	21.0	22.0	-0.007	0.04	1000.0	-1000.0	-0.02	-1000.0
Aurora C signaling	0.0	6.0	7.0	-0.0	0.045	1000.0	-1000.0	-0.01	-1000.0
Insulin-mediated glucose transport	0.0	20.0	32.0	-0.017	0.052	1000.0	-1000.0	-0.023	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	7.0	27.0	-0.011	0.065	1000.0	-1000.0	-0.026	-1000.0
Arf6 trafficking events	0.0	62.0	71.0	-0.045	0.051	1000.0	-1000.0	-0.032	-1000.0
VEGFR1 specific signals	0.0	54.0	56.0	-0.027	0.061	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by PRL	0.0	32.0	34.0	-0.039	0.046	1000.0	-1000.0	-0.025	-1000.0
Arf1 pathway	0.0	42.0	54.0	-0.017	0.05	1000.0	-1000.0	-0.013	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.071	1000.0	-1000.0	0.0	-1000.0
Total	623	40050	7203	-8.08835822699	-992.883014924	131000	-131000	-3.52413144222	-131000