Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Chi-square test_P	Chi-square test_Q
NRAS	9 (29%)	22	0.70425	1	0.020719	1	1	1	1	1	0.6849	1	0.86613	1	0.70425	1	0.59353	1
TPTE	15 (48%)	16	0.28897	1	0.72239	1	1	1	0.28063	1	0.90057	1	0.10894	1	0.28897	1	0.57781	1
TP53	10 (32%)	21	0.053802	1	0.44136	1	0.36601	1	1	1	0.024851	1	0.058109	1	1	1	0.70448	1
GRXCR1	10 (32%)	21	0.70425	1	1	1	0.62139	1	0.53924	1	0.31177	1	0.16987	1	0.45779	1	0.61691	1
BRAF	9 (29%)	22	0.43315	1	0.69275	1	0.62139	1	0.53924	1	0.88656	1	0.82938	1	1	1	0.35587	1
TRAT1	7 (23%)	24	0.68508	1	1	1	1	1	1	1	0.22452	1	0.93963	1	0.037251	1	0.28611	1
ZNF585B	9 (29%)	22	1	1	0.69275	1	0.051979	1	0.25692	1	0.37159	1	0.060194	1	0.053802	1	0.19662	1
TPTE2	12 (39%)	19	0.14888	1	1	1	0.40503	1	0.60361	1	0.24282	1	0.012599	1	0.47255	1	0.60785	1
OR51S1	11 (35%)	20	0.45779	1	0.15349	1	0.34522	1	0.25692	1	0.042507	1	0.12102	1	1	1	0.46545	1
RAC1	5 (16%)	26	0.33259	1	0.63581	1	1	1	1	1	0.032723	1	0.023336	1	1	1	0.27284	1
CDKN2A	6 (19%)	25	0.17192	1	0.36967	1	1	1	1	1	0.027723	1	0.1378	1	1	1	0.020053	1
C7	14 (45%)	17	0.47949	1	0.14933	1	0.37071	1	0.59006	1	0.48475	1	0.15707	1	0.47949	1	0.366	1
C15ORF23	6 (19%)	25	0.17192	1	1	1	1	1	1	1	0.027723	1	0.0452	1	0.39439	1	0.92766	1
GLRB	9 (29%)	22	1	1	0.69275	1	0.31849	1	0.27047	1	0.88656	1	1	1	1	1	0.17095	1
FAM58A	5 (16%)	26	1	1	0.14835	1	0.20949	1	0.45285	1	0.3223	1	0.91101	1	1	1	0.045974	1
EPHA6	15 (48%)	16	0.15561	1	0.15561	1	1	1	0.093168	1	0.01547	1	0.013544	1	1	1	0.091465	1
NAP1L2	9 (29%)	22	0.25241	1	0.4564	1	1	1	1	1	0.6849	1	0.10712	1	0.70425	1	0.83782	1
OR4K5	10 (32%)	21	1	1	1	1	0.65702	1	0.58893	1	0.44313	1	0.95227	1	1	1	0.20861	1
SLC9A11	13 (42%)	18	1	1	0.066864	1	0.37071	1	0.59006	1	0.72916	1	0.6546	1	0.28516	1	0.95807	1
ADAMTS20	18 (58%)	13	1	1	0.48088	1	1	1	1	1	0.38573	1	0.88675	1	0.47255	1	0.60515	1
SLC38A4	13 (42%)	18	0.14888	1	0.0039794	1	0.40503	1	1	1	0.065531	1	0.45764	1	1	1	0.17188	1
OR2T2	8 (26%)	23	0.68508	1	1	1	1	1	0.27047	1	0.6058	1	0.94633	1	0.68508	1	0.89862	1
PRB2	11 (35%)	20	0.45779	1	0.47747	1	1	1	1	1	0.16087	1	0.29958	1	1	1	0.59353	1
COL21A1	12 (39%)	19	0.71599	1	0.28831	1	0.051979	1	0.25692	1	0.21761	1	0.64319	1	0.47255	1	0.33541	1
OR4N2	10 (32%)	21	0.70425	1	0.12061	1	1	1	0.58893	1	0.44313	1	0.91051	1	1	1	0.30412	1
PROX1	7 (23%)	24	1	1	0.19755	1	0.62139	1	1	1	0.48463	1	0.18533	1	0.21997	1	0.60974	1
ANGPT1	10 (32%)	21	1	1	1	1	1	1	1	1	0.31177	1	0.20922	1	0.25241	1	0.22251	1
C8A	11 (35%)	20	0.13505	1	1	1	0.34522	1	1	1	0.18247	1	0.84479	1	0.71599	1	0.67644	1
SERPINB11	7 (23%)	24	0.21997	1	0.67055	1	1	1	1	1	0.41837	1	0.83565	1	1	1	0.53978	1
C18ORF34	11 (35%)	20	0.45779	1	1	1	0.65702	1	1	1	0.18247	1	0.48694	1	0.71599	1	0.051795	1
FRG2B	7 (23%)	24	1	1	0.41169	1	1	1	1	1	0.87116	1	0.93963	1	1	1	0.75571	1
LPPR1	5 (16%)	26	1	1	0.14835	1	0.62139	1	1	1	0.59551	1	1	1	1	1	0.79818	1
THEMIS	10 (32%)	21	1	1	0.28022	1	1	1	1	1	0.55542	1	0.87074	1	1	1	0.45527	1
SNAP91	10 (32%)	21	0.70425	1	0.44136	1	0.34522	1	1	1	0.79375	1	0.83733	1	0.25241	1	0.48039	1
SLC27A6	8 (26%)	23	1	1	0.23991	1	0.36601	1	1	1	0.45119	1	0.2067	1	0.11339	1	0.48652	1
CXORF22	11 (35%)	20	0.065893	1	0.70738	1	1	1	1	1	0.033602	1	0.0073121	1	0.45779	1	0.11752	1
NOBOX	8 (26%)	23	0.43315	1	0.698	1	0.34522	1	1	1	0.6058	1	0.77272	1	0.015499	1	0.26841	1
MUC7	8 (26%)	23	0.68508	1	1	1	1	1	1	1	0.20069	1	0.77272	1	1	1	0.81001	1
GIMAP7	6 (19%)	25	1	1	1	1	1	1	1	1	0.28025	1	0.81176	1	1	1	0.43579	1
SYT17	6 (19%)	25	0.39439	1	0.020887	1	1	1	1	1	0.18792	1	0.60241	1	0.0067977	1	0.47024	1
ASB15	9 (29%)	22	0.70425	1	0.23295	1	0.36601	1	1	1	1	1	0.54436	1	1	1	0.47884	1
OR4A15	8 (26%)	23	0.68508	1	1	1	1	1	0.27047	1	0.26253	1	0.33247	1	1	1	0.5472	1
PROL1	9 (29%)	22	1	1	0.23295	1	1	1	1	1	0.88656	1	0.9055	1	0.43315	1	0.065344	1
DSG3	16 (52%)	15	1	1	0.72239	1	1	1	1	1	1	1	0.89181	1	1	1	0.85331	1
OPRK1	9 (29%)	22	1	1	1	1	0.36601	1	0.27273	1	0.14581	1	0.096618	1	0.70425	1	0.19662	1
PCSK5	13 (42%)	18	0.72239	1	0.71684	1	1	1	1	1	0.72916	1	0.88675	1	0.72239	1	0.90513	1
OR52A1	8 (26%)	23	0.68508	1	1	1	0.27273	1	1	1	0.45119	1	0.89602	1	0.68508	1	0.61129	1
ACSM2B	10 (32%)	21	1	1	0.44136	1	1	1	0.58893	1	1	1	0.83733	1	0.70425	1	0.30412	1
NOL4	11 (35%)	20	0.45779	1	0.47747	1	0.40503	1	0.60361	1	0.065932	1	0.29958	1	0.065893	1	0.35587	1
OXA1L	4 (13%)	27	1	1	0.30412	1	1	1	1	1	0.81541	1	0.81313	1	0.33259	1	0.36704	1
PPFIA2	12 (39%)	19	1	1	0.7241	1	1	1	1	1	0.89629	1	0.95625	1	0.71599	1	0.93286	1
IL1F8	6 (19%)	25	1	1	0.067112	1	1	1	0.45285	1	1	1	0.086462	1	0.017674	1	0.16903	1
UGT2A1	7 (23%)	24	1	1	0.41169	1	0.27273	1	1	1	1	1	0.60565	1	1	1	0.75571	1
SYT13	4 (13%)	27	1	1	1	1	0.52569	1	1	1	0.048022	1	0.18039	1	0.59956	1	0.079096	1
ASAH2	6 (19%)	25	0.082932	1	1	1	1	1	1	1	0.44483	1	0.86652	1	0.082932	1	0.54387	1
ZNF679	7 (23%)	24	0.21997	1	1	1	1	1	1	1	0.64476	1	0.60565	1	0.21997	1	0.75571	1
C10ORF54	6 (19%)	25	0.17192	1	0.66382	1	1	1	1	1	0.15095	1	0.16507	1	1	1	0.18546	1
C10ORF120	7 (23%)	24	0.39439	1	0.67055	1	0.62139	1	1	1	0.10245	1	0.018712	1	0.21997	1	0.60974	1
CHSY1	5 (16%)	26	0.17192	1	1	1	1	1	1	1	0.17845	1	0.59214	1	0.17192	1	0.40059	1
CSF2RA	6 (19%)	25	0.39439	1	0.66382	1	0.14208	1	0.19368	1	0.86195	1	0.63663	1	1	1	0.78596	1
KCND2	10 (32%)	21	1	1	1	1	0.36601	1	1	1	0.31177	1	0.61808	1	0.70425	1	0.64586	1
SPEF2	12 (39%)	19	0.27337	1	1	1	1	1	1	1	0.081648	1	0.73694	1	0.71599	1	0.04222	1
RPGRIP1	8 (26%)	23	1	1	0.41248	1	0.62139	1	1	1	0.6058	1	0.73694	1	0.43315	1	0.71119	1
OR2L3	4 (13%)	27	0.59956	1	0.30412	1	0.52569	1	1	1	0.53014	1	0.74448	1	1	1	0.72732	1
CCDC54	6 (19%)	25	0.17192	1	0.66382	1	0.62139	1	0.53924	1	0.23095	1	0.41131	1	1	1	0.28964	1
KLHL14	7 (23%)	24	0.39439	1	1	1	1	1	0.27047	1	0.48463	1	0.60565	1	1	1	0.68244	1
ZFX	7 (23%)	24	1	1	1	1	1	1	1	1	0.7552	1	0.93963	1	0.68508	1	0.85981	1
KLHL13	10 (32%)	21	1	1	0.067989	1	1	1	1	1	0.79375	1	1	1	0.70425	1	0.13073	1
NSUN7	5 (16%)	26	1	1	1	1	1	1	0.45285	1	1	1	1	1	1	1	0.47843	1
VEGFC	6 (19%)	25	1	1	0.18477	1	1	1	0.53924	1	0.52013	1	0.41131	1	0.082932	1	0.20326	1
TMEM202	5 (16%)	26	0.17192	1	0.63581	1	0.62139	1	0.19368	1	0.82909	1	0.68113	1	0.65394	1	0.65708	1
ERC2	15 (48%)	16	0.15561	1	0.15561	1	0.018625	1	0.28063	1	0.084534	1	0.21359	1	0.28897	1	0.26275	1
GRM3	12 (39%)	19	0.71599	1	0.28831	1	0.17596	1	0.12727	1	0.081648	1	0.11071	1	0.14888	1	0.11429	1
CDH12	9 (29%)	22	0.25241	1	0.13166	1	1	1	0.27273	1	0.88656	1	0.20135	1	0.25241	1	0.40207	1
SIRPB1	7 (23%)	24	1	1	0.67055	1	0.12433	1	0.53924	1	0.48463	1	0.32544	1	0.68508	1	0.57431	1