rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 MYC(2), SP1(2), TP53(11), WT1(3) 324396 18 14 17 1 8 1 1 3 5 0 0.00997 0.0120 1.000 2 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CCND1(1), CDK4(2), CDKN1A(1), CDKN1B(1), CDKN2A(6), E2F1(2), E2F2(1), PRB1(8), TP53(11) 386767 33 19 30 5 17 1 1 5 9 0 0.00514 0.0186 1.000 3 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(2), MMP14(2), MMP2(3), MMP9(4), RECK(2), TIMP1(1), TIMP3(1), TIMP4(2) 340497 17 15 17 2 10 2 1 4 0 0 0.0189 0.0378 1.000 4 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(4) 32727 4 4 4 0 3 1 0 0 0 0 0.131 0.0389 1.000 5 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(2), DCN(6), FMOD(2), KERA(8), LUM(4) 161484 22 15 22 5 16 2 3 1 0 0 0.0163 0.0446 1.000 6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(2), CCND1(1), CCNE1(1), CCNE2(3), CDK4(2), CDKN1B(1), CDKN2A(6), E2F1(2), E2F2(1), E2F4(1), PRB1(8) 412938 28 19 26 5 16 0 2 5 5 0 0.0244 0.0670 1.000 7 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(3), SNAP25(2), STX1A(1) 149636 8 7 8 1 3 1 0 1 3 0 0.0893 0.154 1.000 8 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(2), GRIA2(5), PPP1R1B(1) 168715 8 8 7 1 6 0 0 0 2 0 0.114 0.221 1.000 9 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(1), CDC34(1), CUL1(2), E2F1(2), FBXW7(4), RB1(2), TFDP1(1) 373766 13 10 13 2 5 1 2 1 3 1 0.0712 0.269 1.000 10 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(1), CDKN2A(6), E2F1(2), MYC(2), PIK3CA(3), POLR1A(5), POLR1B(4), RAC1(5), RB1(2), TBX2(2), TP53(11) 926877 43 19 37 4 27 2 0 3 10 1 5.00e-05 0.311 1.000 11 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP5(1), ACPP(2), ENPP1(4), ENPP3(7), FLAD1(2), TYR(3) 440888 19 13 19 2 12 1 1 1 4 0 0.0131 0.374 1.000 12 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 23498 1 1 1 0 1 0 0 0 0 0 0.677 0.375 1.000 13 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(6), GABRA2(4), GABRA3(6), GABRA4(3), GABRA5(1), GABRA6(8), PRKCE(2) 352674 30 17 28 8 21 2 1 4 2 0 0.0353 0.395 1.000 14 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(1), ATM(2), BAX(2), CCND1(1), CCNE1(1), CDK4(2), CDKN1A(1), E2F1(2), RB1(2), TIMP3(1), TP53(11) 824210 26 16 25 5 10 3 1 4 7 1 0.0640 0.421 1.000 15 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(3), HLA-DRA(3), HLA-DRB1(2) 138490 8 7 8 3 7 0 0 0 1 0 0.177 0.436 1.000 16 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(1), NR3C1(3), PPARG(2), RETN(1), RXRA(2) 266387 10 9 10 3 5 1 0 2 2 0 0.235 0.492 1.000 17 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(2), IFNGR1(2), IFNGR2(1), JAK2(1), LIN7A(3), NFKB1(4), NFKBIA(1), RB1(2), RELA(1), TNFRSF1A(1), TNFRSF1B(2), TP53(11), USH1C(1), WT1(3) 823447 35 17 34 8 15 0 1 8 10 1 0.0567 0.497 1.000 18 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(2) 51141 2 2 2 1 2 0 0 0 0 0 0.710 0.509 1.000 19 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(4), DAXX(5), HRAS(2), PAX3(1), PML(1), RARA(1), RB1(2), SP100(1), TNFRSF1A(1), TNFRSF1B(2), TP53(11) 859109 31 19 30 7 14 3 2 4 7 1 0.0529 0.510 1.000 20 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(2), CDC25A(3), CDC25B(1), CDC25C(1), CDK4(2), MYT1(4), RB1(2), TP53(11), WEE1(2) 802706 28 17 27 6 11 1 1 6 8 1 0.108 0.556 1.000 21 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), MIOX(1) 387400 11 8 11 3 3 4 0 2 2 0 0.218 0.597 1.000 22 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYB(1), RB1(2), SP1(2) 305594 5 5 5 1 2 1 0 0 1 1 0.404 0.609 1.000 23 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 HMGCL(3), OXCT1(1) 154223 4 4 4 1 2 1 0 1 0 0 0.562 0.609 1.000 24 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA2(1), PSMA4(1), PSMA5(2), PSMA6(1), PSMB10(1), PSMB2(1), PSMB7(1), PSMB8(3) 403101 12 9 12 2 5 1 2 3 1 0 0.179 0.625 1.000 25 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(3), PARK2(2), SNCA(1), SNCAIP(12), UBE2E2(1), UBE2F(1), UBE2G2(1) 294913 21 17 21 5 15 4 0 1 1 0 0.0767 0.636 1.000 26 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(3), CD4(1), HLA-DRA(3), HLA-DRB1(2), IL1B(1), IL4(1), IL5RA(7) 243218 18 15 17 9 14 0 0 0 4 0 0.195 0.643 1.000 27 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(2), CCND1(1), CCND2(1), CCNE1(1), CDC25A(3), CDK4(2), CDK6(1), CDKN1A(1), CDKN1B(1), CDKN2A(6), CDKN2C(1), E2F1(2), RB1(2), RBL1(2), TFDP1(1) 737922 27 17 25 5 13 1 3 4 5 1 0.0177 0.669 1.000 28 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(4), SRP19(1), SRP54(1), SRP68(1), SRP72(1), SRP9(1) 348713 9 9 7 2 5 0 0 3 1 0 0.363 0.682 1.000 29 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2) 363466 12 9 12 4 5 3 0 2 2 0 0.244 0.684 1.000 30 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2) 363466 12 9 12 4 5 3 0 2 2 0 0.244 0.684 1.000 31 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(2), FYN(1), MAPK14(3), THBS1(10) 339453 16 12 16 4 12 0 0 1 3 0 0.110 0.689 1.000 32 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(1), CDKN1B(1), CUL1(2), E2F1(2), RB1(2), TFDP1(1) 393491 9 8 9 2 3 1 1 1 2 1 0.204 0.703 1.000 33 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(1), MAP3K14(2), NFKB1(4), NFKBIA(1), RELA(1), TP53(11) 445365 20 17 19 5 11 0 0 3 6 0 0.168 0.709 1.000 34 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH6(2), ADH7(1), ADHFE1(2) 257435 33 19 32 11 23 3 2 3 2 0 0.138 0.733 1.000 35 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), CHAT(7), CHKA(1), PCYT1A(2), PDHA2(6), SLC18A3(1) 316243 18 13 18 4 16 2 0 0 0 0 0.0195 0.767 1.000 36 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP5(1), ACP6(3), ACPP(2), ENPP1(4), ENPP3(7), FLAD1(2), MTMR1(1), MTMR6(1), TYR(3) 686084 24 16 24 3 17 1 1 1 4 0 0.00870 0.768 1.000 37 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 SLPI(2) 78608 2 2 2 1 2 0 0 0 0 0 0.680 0.780 1.000 38 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2) 97538 2 2 2 0 1 0 0 1 0 0 0.479 0.804 1.000 39 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(13), CR2(10), FCGR2B(1), HLA-DRA(3), HLA-DRB1(2), ITGAL(8), ITGB2(6), PTPRC(4) 687849 47 22 47 12 31 4 2 2 8 0 0.0166 0.835 1.000 40 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(4), NFKBIA(1), PLCB1(18), PRKCA(5), RELA(1) 374805 30 18 29 9 27 1 0 0 2 0 0.0536 0.836 1.000 41 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IL12B(1), IL18(2), IL2(1) 135129 5 4 5 3 4 1 0 0 0 0 0.636 0.849 1.000 42 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(3), BMPR1B(2), BMPR2(1) 285764 6 6 6 2 2 2 0 1 1 0 0.476 0.852 1.000 43 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(2), CYR61(1), DUSP14(1), IL18(2), IL1A(3), IL1R1(3), MYOG(2), NR4A3(3), WDR1(1) 486032 18 12 18 5 9 3 1 2 3 0 0.180 0.856 1.000 44 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 CCND1(1), CCNE1(1), CDK4(2), CDK6(1), CDKN1A(1), CDKN1B(1), E2F1(2), HRAS(2), MAPK1(2), MAPK3(1), NFKB1(4), NFKBIA(1), PIK3CA(3), RAC1(5), RAF1(3), RB1(2), RELA(1), TFDP1(1) 920521 34 22 31 8 20 4 1 4 4 1 0.0203 0.860 1.000 45 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), FARSA(2), FARSB(3), GOT2(1), PAH(2), TAT(2), YARS(1), YARS2(2) 398378 15 12 15 4 10 2 0 1 2 0 0.0835 0.875 1.000 46 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(2), BCMO1(4), RDH5(1) 178438 8 7 8 5 5 0 1 0 2 0 0.583 0.910 1.000 47 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 CDC42(1), RAC1(5), WASL(4) 372289 10 9 7 2 8 0 0 1 1 0 0.228 0.916 1.000 48 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), CAT(1), EPX(4), LPO(4), MPO(2), PRDX2(1), PRDX6(1), TPO(11) 541448 25 17 25 8 19 2 0 3 1 0 0.0477 0.926 1.000 49 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(5), IARS(5), LARS(1), PDHA2(6) 460023 17 11 17 3 13 0 1 1 2 0 0.0758 0.926 1.000 50 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(3), CARS2(1), CDO1(2), GOT2(1), LDHAL6B(1), LDHC(3), MPST(1), SDS(1), SULT1B1(3), SULT1C2(1), SULT1C4(3), SULT4A1(3) 572197 23 17 23 7 17 0 3 0 3 0 0.0776 0.932 1.000 51 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 APAF1(1), CASP9(2), DAXX(5), FAS(1), FASLG(2), HSPB1(2), IL1A(3), MAPKAPK2(2), MAPKAPK3(1) 520183 19 15 19 6 10 3 2 2 2 0 0.160 0.935 1.000 52 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(1), ALDOB(4) 180250 5 4 4 1 5 0 0 0 0 0 0.183 0.939 1.000 53 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(3), GAD1(4), HDC(5), PNMT(2), TH(3), TPH1(1) 273937 18 13 17 9 15 1 1 0 1 0 0.237 0.940 1.000 54 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(2), AASS(1), KARS(2) 213100 5 5 5 1 5 0 0 0 0 0 0.366 0.941 1.000 55 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(4), POLR2A(1), POLR2B(6), POLR2E(1), POLRMT(1) 611775 13 10 13 1 6 2 0 2 3 0 0.0240 0.941 1.000 56 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), FARS2(2), GOT2(1), PAH(2), TAT(2), YARS(1) 381516 10 9 10 2 9 1 0 0 0 0 0.0603 0.942 1.000 57 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(3), CDC25B(1), CDKN1A(1), NEK1(1), WEE1(2) 318318 8 6 8 2 3 2 1 1 1 0 0.386 0.942 1.000 58 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(2), PLCD1(1), PRKCA(5), TGM2(2) 227613 10 8 10 4 8 1 0 0 1 0 0.158 0.943 1.000 59 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT2(1), TAT(2) 120422 3 3 3 2 3 0 0 0 0 0 0.661 0.945 1.000 60 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(2), CCNE1(1), CDC34(1), CUL1(2), E2F1(2), RB1(2), TFDP1(1) 390586 11 8 11 4 5 1 1 1 2 1 0.339 0.948 1.000 61 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH5(1), ADH6(2), ADH7(1), ADHFE1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1) 603202 44 22 43 14 27 6 2 5 4 0 0.0453 0.953 1.000 62 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(1), CSF1(3), CSF3(2), EPO(2), IL2(1), IL4(1), IL7(2), IL9(1) 276624 13 10 13 8 8 1 0 1 3 0 0.486 0.955 1.000 63 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(4), GGT1(1) 186246 5 5 5 3 3 0 0 1 1 0 0.566 0.957 1.000 64 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(1), ITGA4(13), ITGAL(8), ITGB1(2), ITGB2(6), SELE(8), SELL(3) 549229 41 22 41 12 30 2 1 2 6 0 0.0430 0.958 1.000 65 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), EHHADH(1), HADHA(1), SDS(1) 554833 15 10 15 6 7 3 0 3 2 0 0.315 0.965 1.000 66 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(1), ADORA3(4), P2RY1(1), P2RY2(5) 271700 11 8 11 7 6 2 0 0 3 0 0.280 0.972 1.000 67 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 HRAS(2), MAPK1(2), MAPK3(1), NGFR(5), RAF1(3) 372233 13 10 13 5 8 2 0 2 1 0 0.192 0.972 1.000 68 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS2(2), SULT1A2(1), SULT1E1(6), SULT2A1(4), SUOX(1) 279100 14 9 13 5 10 0 0 2 2 0 0.330 0.973 1.000 69 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(2), NDUFB5(2), NDUFS2(1) 320708 5 5 5 1 4 0 0 1 0 0 0.450 0.975 1.000 70 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 MAPK1(2), MAPK14(3), NFE2L2(2), PRKCA(5) 406195 12 9 12 4 8 2 0 1 1 0 0.231 0.976 1.000 71 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(1), GPR109B(1), GPR161(3), GPR171(3), GPR18(1), GPR34(2), GPR39(3), GPR45(2), GPR65(2), GPR75(3), GPR81(2) 447058 23 18 23 11 18 1 0 0 4 0 0.0520 0.977 1.000 72 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPL(6), ALPP(2), ALPPL2(6), GGH(1) 291793 17 12 16 7 16 0 0 0 1 0 0.0996 0.978 1.000 73 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(1), POLD2(1), POLE(6), POLL(4), POLQ(9) 764678 21 16 21 5 12 0 1 5 3 0 0.0584 0.978 1.000 74 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(1), EPX(4), LPO(4), MPO(2), PRDX6(1), TPO(11) 534598 24 16 24 8 18 2 0 3 1 0 0.0648 0.980 1.000 75 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 SDHA(1), SDHC(1), SDHD(1), UQCRC1(1) 305187 4 4 4 1 3 0 0 0 1 0 0.469 0.981 1.000 76 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD4(1), HLA-DRA(3), HLA-DRB1(2), IL10(2), IL2(1), IL4(1) 179976 11 10 11 7 10 0 0 0 1 0 0.432 0.983 1.000 77 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(14), C5(2), C6(18), C7(19), C8A(13), C9(5) 565844 71 27 66 20 58 2 0 5 6 0 0.00500 0.984 1.000 78 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 CDKN1A(1), EPO(2), EPOR(1), GRIN1(3), JAK2(1), NFKB1(4), NFKBIA(1), RELA(1) 571670 14 12 14 4 8 1 1 1 3 0 0.244 0.985 1.000 79 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(1) 144548 1 1 1 1 1 0 0 0 0 0 0.869 0.985 1.000 80 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(3), GOT2(1), LDHC(3), MPST(1) 312918 8 7 8 3 7 0 1 0 0 0 0.358 0.985 1.000 81 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(3), CDC25B(1), CDC25C(1), PRKCA(5), PTPRA(2), SRC(1) 424371 13 9 13 4 8 3 1 1 0 0 0.181 0.985 1.000 82 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(1), UXS1(1) 177160 2 2 2 5 0 0 1 0 1 0 0.995 0.986 1.000 83 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(2), AASDH(3), AASS(1), KARS(2) 315378 8 7 8 2 8 0 0 0 0 0 0.342 0.987 1.000 84 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF3(2), EPO(2), FLT3(7), IL1A(3), IL9(1), KITLG(1) 377058 16 12 16 8 10 0 1 2 3 0 0.442 0.988 1.000 85 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(1), IL10(2), IL12B(1), IL15(1), IL16(5), IL18(2), IL1A(3), IL2(1), IL4(1), IL9(1), LTA(1) 450320 20 14 20 7 14 1 1 1 3 0 0.0905 0.989 1.000 86 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(4), GBA3(4), LPO(4), MPO(2), PRDX2(1), PRDX6(1), TPO(11), TYR(3) 441933 30 20 30 10 23 2 0 3 2 0 0.0473 0.990 1.000 87 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(11), CD28(1), CD3D(2), ITGAL(8), ITGB2(6), PTPRC(4), THY1(1) 484241 33 17 32 11 25 2 1 2 3 0 0.0566 0.990 1.000 88 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(11), CD34(1), CD3D(2), CD4(1), CSF3(2), KITLG(1) 279767 18 10 17 7 14 1 0 2 1 0 0.216 0.991 1.000 89 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), HADHA(1), HADHB(2), HSD17B4(1), MECR(3) 389784 8 8 8 4 4 0 0 1 3 0 0.603 0.991 1.000 90 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSS(2), NFKB1(4), NOX1(3), RELA(1), XDH(13) 449339 23 19 23 9 18 1 2 1 1 0 0.146 0.992 1.000 91 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(1), CS(1), FH(2), IDH2(1), OGDH(3), SDHA(1) 433193 9 8 9 4 7 0 0 0 2 0 0.373 0.992 1.000 92 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLUD2(2) 208575 2 2 2 2 0 0 1 0 1 0 0.917 0.994 1.000 93 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(1), ACO2(1), FH(2), IDH1(1), IDH2(1), MDH2(2) 409679 8 6 8 3 5 0 1 0 2 0 0.363 0.994 1.000 94 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 CDC42(1), PDGFRA(9), PIK3CA(3), RAC1(5), WASL(4) 614009 22 15 19 7 14 1 0 4 3 0 0.334 0.995 1.000 95 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA3(4), GGT1(1) 245631 5 5 5 3 3 0 0 1 1 0 0.615 0.996 1.000 96 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), EHHADH(1), HADHA(1), SDS(1) 222237 4 4 4 3 3 0 0 1 0 0 0.765 0.996 1.000 97 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 EHHADH(1), GCDH(1), HADHA(1), SDS(1) 357910 4 4 4 2 2 1 0 1 0 0 0.678 0.996 1.000 98 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(2), RDH11(1), RDH12(1), RDH13(1) 220533 5 5 5 9 4 0 0 0 1 0 0.987 0.996 1.000 99 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(1), CFLAR(1) 178716 2 2 2 2 1 0 0 1 0 0 0.926 0.996 1.000 100 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(1), UGP2(1), UXS1(1) 225714 3 3 3 5 1 0 1 0 1 0 0.984 0.996 1.000 101 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(5), PLCG1(1), PRKCA(5), PTK2B(2) 307882 13 8 13 7 9 2 0 0 2 0 0.369 0.997 1.000 102 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), CSF1(3), IL1B(1), MST1(1), MST1R(2) 299975 8 7 8 4 5 1 1 0 1 0 0.564 0.997 1.000 103 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(4), DFFB(1), GZMA(5), HMGB2(1), PRF1(2), SET(1) 484304 14 10 14 5 9 0 1 2 2 0 0.475 0.997 1.000 104 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 DAG1(2), GNAQ(1), ITPKB(2) 275692 5 5 5 2 5 0 0 0 0 0 0.371 0.997 1.000 105 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(5), DPYD(18), DPYS(6), ENPP1(4), ENPP3(7), PANK2(2), PANK3(2), PANK4(1), PPCS(1), UPB1(1) 634552 47 18 46 11 37 2 1 3 4 0 0.00523 0.997 1.000 106 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT2(1), FUT3(2), FUT5(1), FUT6(1) 227287 5 5 5 5 2 0 1 1 1 0 0.854 0.997 1.000 107 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(1), ESR1(2), GREB1(5), HSPB1(2), MTA3(1), PDZK1(1), TUBA8(1) 490581 14 10 14 5 10 0 1 2 1 0 0.209 0.997 1.000 108 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 CBS(2), MUT(1) 233417 3 3 3 2 3 0 0 0 0 0 0.720 0.998 1.000 109 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(4), CLOCK(1), CRY1(1), CRY2(2), CSNK1E(1), PER1(3) 385974 12 10 12 5 7 1 1 1 2 0 0.501 0.998 1.000 110 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(4), GBA3(4), LPO(4), MPO(2), PRDX6(1), TPO(11) 384628 26 18 26 10 19 2 0 3 2 0 0.102 0.998 1.000 111 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR1(2), IFNGR2(1), JAK1(1), JAK2(1), STAT1(3) 372106 8 4 8 7 1 0 0 4 3 0 0.997 0.998 1.000 112 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(1), ALAS2(1), CPOX(2), PPOX(1) 345125 5 5 5 2 4 0 1 0 0 0 0.493 0.998 1.000 113 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 AKT2(1), AKT3(2), BTK(4), CDKN2A(6), DAPP1(3), GSK3B(1), IARS(5), IGFBP1(1), INPP5D(13), PDK1(1), PIK3CA(3), PPP1R13B(2), PTEN(1), RPS6KA1(3), RPS6KB1(1), SFN(1), SHC1(1), SOS1(3), SOS2(5), TEC(2), YWHAE(1), YWHAG(1), YWHAQ(2) 1647734 63 26 61 15 38 5 5 5 10 0 0.00538 0.998 1.000 114 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(6), G6PD(1), GCLC(1), GCLM(2), GGT1(1), GPX3(1), GPX5(1), GSS(2), GSTA1(2), GSTA2(2), GSTM2(2), GSTM3(2), GSTM4(2), GSTM5(1), IDH1(1), IDH2(1), MGST1(1), MGST2(1), PGD(2) 822222 32 19 31 10 22 0 2 4 4 0 0.0287 0.998 1.000 115 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(2), ATR(8), CDC25C(1), TP53(11) 730708 22 15 21 6 12 0 1 3 6 0 0.284 0.998 1.000 116 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(2), ACAA2(1), EHHADH(1), HADHA(1), HADHB(2), SDS(1) 383253 8 8 8 4 5 0 0 1 2 0 0.598 0.998 1.000 117 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(2), NR0B2(1), NR1H4(2), RXRA(2) 247883 7 6 7 5 5 1 0 0 1 0 0.601 0.998 1.000 118 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), ACO2(1), CS(1), HAO1(4), HAO2(5), MDH2(2) 584357 14 12 14 6 9 1 1 0 3 0 0.270 0.999 1.000 119 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(5), POLR1B(4), POLR2A(1), POLR2B(6), POLR2E(1), POLR3A(2), POLR3B(4), POLR3G(1), POLR3GL(1) 1071884 25 18 25 5 15 1 1 3 5 0 0.0344 0.999 1.000 120 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(4), HRAS(2), MAPK1(2), MAPK3(1), MYC(2), NFKB1(4), NFKBIA(1), PLCB1(18), PRKCA(5), RAF1(3), RELA(1) 710758 43 22 42 14 32 5 1 2 3 0 0.0201 0.999 1.000 121 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP7(2), DFFB(1), HMGB2(1), TOP2A(2), TOP2B(1) 411875 7 7 7 3 6 1 0 0 0 0 0.622 0.999 1.000 122 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1), OAT(2) 250175 3 3 3 2 2 1 0 0 0 0 0.743 0.999 1.000 123 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(5), PSAT1(1) 222631 6 5 6 4 6 0 0 0 0 0 0.739 0.999 1.000 124 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(4), ENO1(2), PFKL(2), PGK1(1), PKLR(4) 420891 13 10 12 5 10 1 0 1 1 0 0.128 0.999 1.000 125 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(1), ITGAL(8), ITGAM(9), ITGB2(6), SELE(8), SELL(3) 470384 35 19 35 15 22 2 1 3 7 0 0.187 0.999 1.000 126 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), BAX(2), BCL10(1), BCL2L11(3), CASP8AP2(1), CASP9(2), CES1(1) 491053 11 8 11 7 6 2 1 0 2 0 0.801 0.999 1.000 127 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), IL10(2), IL10RA(3), IL1A(3), JAK1(1), STAT1(3), STAT3(1), STAT5A(1) 558340 15 13 15 7 8 1 1 3 2 0 0.460 0.999 1.000 128 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(1), ITGA4(13), ITGAL(8), ITGAM(9), ITGB1(2), ITGB2(6), SELE(8), SELL(3), SELP(10) 722789 60 23 60 20 43 2 2 5 8 0 0.0404 0.999 1.000 129 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(2), F2(3), F2R(2), F5(9), F7(2), FGA(11), FGG(2), PROC(1), PROS1(4), SERPINC1(1), TFPI(4) 749885 41 24 40 12 28 5 0 4 4 0 0.0633 0.999 1.000 130 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), ACO2(1), AFMID(2), CS(1), HAO1(4), HAO2(5), MDH2(2) 612327 16 14 16 9 10 1 2 0 3 0 0.452 1.000 1.000 131 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(2), FDPS(1), HMGCR(3), MVK(2) 502576 8 7 8 4 5 0 0 2 1 0 0.645 1.000 1.000 132 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), BHMT(1), CBS(2), DNMT1(6), DNMT3A(2), DNMT3B(3), MARS2(2), MAT1A(1), MTR(2) 807056 20 14 20 9 11 2 4 1 2 0 0.370 1.000 1.000 133 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(4), EP300(7), ESR1(2), MAPK1(2), MAPK3(1), PELP1(5), SRC(1) 669543 22 15 22 8 17 0 1 2 2 0 0.313 1.000 1.000 134 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(2), CD4(1), FYN(1), HLA-DRA(3), HLA-DRB1(2), LCK(3), PTPRC(4), ZAP70(2) 403063 18 13 18 8 15 1 0 1 1 0 0.308 1.000 1.000 135 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(5), DPYD(18), DPYS(6), ENPP1(4), ENPP3(7), ILVBL(2), PANK2(2), PANK3(2), PANK4(1), PPCS(1), UPB1(1), VNN1(1) 788259 50 18 49 13 39 2 1 4 4 0 0.00535 1.000 1.000 136 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(2), ALOX15(4), ALOX15B(2), ALOX5(4), DPEP1(2), GGT1(1), LTA4H(2), PLA2G2A(1), PLA2G6(2), PTGDS(1), PTGIS(4), PTGS1(5), PTGS2(3), TBXAS1(6) 685266 39 22 39 15 30 2 1 3 3 0 0.0226 1.000 1.000 137 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(1), MTMR6(1), NFS1(1), TPK1(2) 294608 5 5 5 3 5 0 0 0 0 0 0.743 1.000 1.000 138 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(3), GABRA1(6), GABRA2(4), GABRA3(6), GABRA4(3), GABRA5(1), GABRA6(8), GPHN(1), SRC(1), UBQLN1(2) 535378 35 18 33 13 26 3 1 3 2 0 0.112 1.000 1.000 139 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(11), CD28(1), CD3D(2), CD4(1), ITGAL(8), ITGB2(6), PTPRC(4), THY1(1) 507511 34 17 33 13 26 2 1 2 3 0 0.0949 1.000 1.000 140 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 CD3D(2), HLA-A(2), ITGAL(8), ITGB2(6), PRF1(2) 398334 20 15 20 10 13 2 1 1 3 0 0.367 1.000 1.000 141 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(2), FDPS(1), HMGCR(3), MVK(2), NSDHL(1) 600353 9 8 9 4 6 0 0 2 1 0 0.584 1.000 1.000 142 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 BCAR1(2), CDKN1B(1), ITGB1(2), MAPK1(2), MAPK3(1), PDPK1(2), PIK3CA(3), PTEN(1), PTK2(2), SHC1(1), SOS1(3) 879354 20 14 19 6 14 3 0 1 2 0 0.220 1.000 1.000 143 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BIRC3(1), CASP8(1), TNFRSF1A(1), TNFRSF1B(2) 373858 5 5 5 3 5 0 0 0 0 0 0.649 1.000 1.000 144 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL13RA2(1), IL4R(3), JAK1(1), JAK2(1), TYK2(3) 477408 11 10 11 7 5 0 0 4 2 0 0.843 1.000 1.000 145 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL13RA2(1), IL4R(3), JAK1(1), JAK2(1), TYK2(3) 477408 11 10 11 7 5 0 0 4 2 0 0.843 1.000 1.000 146 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 MAP2K3(2), MAPK1(2), MAPK14(3), MAPK3(1), NFKB1(4), PIK3CA(3), RB1(2), RELA(1), SP1(2) 886198 20 16 20 9 13 3 0 1 2 1 0.487 1.000 1.000 147 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(3), GNAQ(1), GNAS(4), HRAS(2), LIMK1(1), MAPK1(2), MAPK3(1), MYL2(2), NOX1(3), PIK3C2G(13), PLCB1(18), PPP1R12B(3), PRKCA(5), PTK2(2), RAF1(3), ROCK2(4) 1142916 67 24 65 23 50 5 1 6 5 0 0.0395 1.000 1.000 148 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), MAP3K14(2), MAPK14(3), NFKB1(4), RELA(1), TNFRSF13B(1), TNFRSF17(1), TRAF3(3), TRAF5(2), TRAF6(2) 659684 20 14 20 6 16 1 0 3 0 0 0.159 1.000 1.000 149 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(2), HK2(5), HK3(3), PGM1(1), PGM3(1) 468673 12 8 12 5 8 2 0 1 1 0 0.288 1.000 1.000 150 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(11), CD44(1), CSF1(3), FCGR3A(2), IL1B(1), SELL(3), SPN(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF8(1), TNFSF8(2) 593002 28 15 28 10 24 1 1 0 2 0 0.0685 1.000 1.000 151 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CD3D(2), CD86(8), CTLA4(1), HLA-DRA(3), HLA-DRB1(2), ICOS(1), IL2(1), ITK(8), LCK(3), PIK3CA(3), PTPN11(5) 583198 38 17 37 10 29 5 1 1 2 0 0.0451 1.000 1.000 152 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(1), JAK2(1), MAPK1(2), MAPK3(1), STAT3(1), TYK2(3) 532469 9 7 9 6 3 1 0 3 2 0 0.819 1.000 1.000 153 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(1), ACOX3(2), FADS2(1), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2) 463120 21 13 21 10 14 1 1 2 3 0 0.335 1.000 1.000 154 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(6), CD2(11), CD33(6), CD5(2), IFNA1(1), IFNB1(1), IL10(2), IL12B(1), IL4(1), ITGAX(5), TLR2(4), TLR4(8), TLR7(4), TLR9(3) 844900 55 20 54 22 40 3 2 4 6 0 0.0171 1.000 1.000 155 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(1), ATM(2), ATR(8), CCNA1(2), CCND1(1), CCNE1(1), CDC25A(3), CDK4(2), CDK6(1), CDKN1A(1), CDKN1B(1), CDKN2A(6), E2F1(2), GSK3B(1), RB1(2), TFDP1(1), TP53(11) 1377778 46 21 43 11 22 2 3 7 11 1 0.0244 1.000 1.000 156 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(5), ENPP1(4), ENPP3(7), NADSYN1(2), NMNAT2(1), NNMT(3), NNT(1), NT5E(1), NT5M(1), QPRT(2) 666990 27 16 27 10 18 2 1 1 5 0 0.168 1.000 1.000 157 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(3), CS(1), ME1(4), PC(1), SLC25A11(1) 426039 10 8 10 6 8 0 0 1 1 0 0.547 1.000 1.000 158 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(1), ATM(2), BRCA1(4), CDKN1A(1), MRE11A(1), NFKB1(4), NFKBIA(1), RAD50(1), RBBP8(2), RELA(1), TP53(11), TP73(2) 1353751 31 20 30 8 16 3 1 4 7 0 0.136 1.000 1.000 159 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA2(1), PSMA4(1), PSMA5(2), PSMA6(1), PSMB2(1), PSMB7(1), RPN2(1), UBE3A(4) 593531 13 11 13 5 7 2 1 2 1 0 0.457 1.000 1.000 160 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(2), CAPN1(1), GSK3B(1), MAPT(3) 414725 7 6 7 7 4 1 1 0 1 0 0.876 1.000 1.000 161 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(2), CDC25A(3), CDC25B(1), CDC25C(1), MYT1(4), WEE1(2) 628119 13 9 13 6 6 1 1 3 2 0 0.690 1.000 1.000 162 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 BDH1(1), HMGCL(3), HMGCS2(7), OXCT1(1) 326748 12 8 11 6 7 3 0 2 0 0 0.619 1.000 1.000 163 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(6), GPT(1), LDHC(3), MAPK14(3) 410014 13 8 13 6 11 0 1 1 0 0 0.416 1.000 1.000 164 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(2), HK2(5), HK3(3), IMPA2(1), PGM1(1), PGM3(1) 533035 13 9 13 7 9 2 0 1 1 0 0.413 1.000 1.000 165 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), FUCA1(2), GLB1(2), HEXA(2), HEXB(2), LCT(13), MAN2C1(1), MANBA(3), NEU1(2), NEU2(2), NEU3(1) 751469 31 18 31 11 24 2 0 4 1 0 0.137 1.000 1.000 166 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(3), ACO1(1), ACO2(1), FH(2), IDH1(1), IDH2(1), MDH2(2) 611276 11 7 11 7 8 0 1 0 2 0 0.601 1.000 1.000 167 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(4), CD2(11), CD3D(2), CD4(1), CXCR3(1), IL12B(1), IL12RB1(6), JAK2(1), STAT4(7), TYK2(3) 662380 37 18 36 14 25 3 1 7 1 0 0.148 1.000 1.000 168 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CBS(2), GGT1(1), MARS2(2), MAT1A(1), PAPSS2(2), SEPHS1(2) 571596 11 10 11 6 6 0 2 2 1 0 0.543 1.000 1.000 169 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(2), EIF2AK4(2), GSK3B(1) 532252 5 4 5 5 4 0 0 0 1 0 0.930 1.000 1.000 170 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), FUCA1(2), GLB1(2), HEXA(2), HEXB(2), LCT(13), MAN2B1(2), MAN2B2(4), MAN2C1(1), MANBA(3), NEU1(2), NEU2(2), NEU3(1) 926306 37 20 37 13 29 2 1 4 1 0 0.0757 1.000 1.000 171 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(4), AKR1D1(6), CYP11B1(5), CYP11B2(3), CYP17A1(1), CYP21A2(4), HSD11B1(1), HSD11B2(1), HSD3B1(4) 445945 29 16 28 15 18 2 2 3 4 0 0.186 1.000 1.000 172 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(4), AKR1D1(6), CYP11B1(5), CYP11B2(3), CYP17A1(1), CYP21A2(4), HSD11B1(1), HSD11B2(1), HSD3B1(4) 445945 29 16 28 15 18 2 2 3 4 0 0.186 1.000 1.000 173 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1G(2), HDAC9(16), MEF2A(2), MEF2C(1), MEF2D(1) 340171 22 15 20 10 18 1 0 1 2 0 0.339 1.000 1.000 174 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(1), CREBBP(4), EP300(7), HDAC3(3), NFKB1(4), NFKBIA(1), RELA(1), TNFRSF1A(1), TNFRSF1B(2), TRAF6(2) 1016261 26 14 26 8 20 0 2 2 2 0 0.160 1.000 1.000 175 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(1), ATP6AP1(1), ATP6V0A1(4), ATP6V0A4(7), ATP6V1B2(2), ATP6V1C2(4), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(2), FDXR(4) 733352 30 16 30 11 19 1 0 4 6 0 0.126 1.000 1.000 176 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(1), ATP6V0A1(4), ATP6V0A4(7), ATP6V1B2(2), ATP6V1C2(4), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(2) 689055 26 15 26 10 16 1 0 3 6 0 0.187 1.000 1.000 177 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(1), ATP6V0A1(4), ATP6V0A4(7), ATP6V1B2(2), ATP6V1C2(4), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(2) 689055 26 15 26 10 16 1 0 3 6 0 0.187 1.000 1.000 178 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(1), ATP6V0A1(4), ATP6V0A4(7), ATP6V1B2(2), ATP6V1C2(4), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(2) 689055 26 15 26 10 16 1 0 3 6 0 0.187 1.000 1.000 179 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(2), CHST11(2), CHST12(2), CHST13(1), CHSY1(6), DSE(6), XYLT1(5) 608427 24 16 24 12 16 3 3 1 1 0 0.251 1.000 1.000 180 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), EHHADH(1), HADHA(1), HSD17B4(1), SIRT5(2), SIRT7(1), VNN2(4) 543871 11 10 11 7 7 1 0 2 1 0 0.767 1.000 1.000 181 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(3), F2R(2), F2RL3(1), HRAS(2), ITGA1(11), ITGB1(2), MAPK1(2), MAPK3(1), PLA2G4A(1), PLCB1(18), PRKCA(5), PTGS1(5), PTK2(2), RAF1(3), SRC(1), SYK(4), TBXAS1(6) 1111808 69 24 67 25 54 6 0 4 5 0 0.0272 1.000 1.000 182 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(2), METTL2B(2), PCYT1A(2), PCYT1B(3), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(3) 643103 18 12 18 9 11 3 1 2 1 0 0.508 1.000 1.000 183 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(1), IFNB1(1), JAK1(1), STAT1(3), TYK2(3) 491562 10 9 10 7 5 0 0 4 1 0 0.899 1.000 1.000 184 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1R(2), C1S(3), C2(2), C3(14), C5(2), C6(18), C7(19), C8A(13), C9(5) 788150 78 27 73 29 62 3 0 6 7 0 0.0365 1.000 1.000 185 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), DPM1(1), FUT8(2), MAN1A1(3), MAN1B1(1), MGAT1(1), MGAT3(4), MGAT4A(2), MGAT5(1), RPN2(1), ST6GAL1(1) 912692 21 16 21 9 14 3 2 1 1 0 0.223 1.000 1.000 186 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CDC25A(3), CDC25B(1), CDC25C(1), SHH(1) 399880 6 6 6 4 3 1 1 1 0 0 0.808 1.000 1.000 187 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT2(1), AGPAT3(2), AGPAT4(3), AGPS(1), ENPP6(3), PAFAH1B1(1), PAFAH1B2(1), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), PLD1(3), PLD2(2), PPAP2B(4), PPAP2C(2) 1066225 40 18 39 13 25 3 1 5 6 0 0.0793 1.000 1.000 188 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(6), ACTN3(3), BCAR1(2), CTNNA1(2), CTNNA2(8), CTNNB1(3), PTK2(2), SRC(1), VCL(2) 862284 30 17 30 11 21 2 1 1 4 1 0.0610 1.000 1.000 189 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(2), CASP8(1), MAPK1(2), MAPK3(1), NFKB1(4), NSMAF(1), RAF1(3), RELA(1), TNFRSF1A(1) 930596 16 11 16 5 12 2 0 1 1 0 0.184 1.000 1.000 190 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 EDN1(2), EP300(7), EPO(2), NOS3(2), VHL(2) 782000 15 12 15 7 9 0 1 2 3 0 0.597 1.000 1.000 191 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), CDC42(1), DAXX(5), DDIT3(1), ELK1(1), HRAS(2), HSPB1(2), MAP3K5(7), MAP3K7(1), MAP3K9(8), MAPK14(3), MAPKAPK2(2), MEF2A(2), MEF2C(1), MEF2D(1), MKNK1(1), MYC(2), PLA2G4A(1), RAC1(5), RPS6KA5(1), SHC1(1), STAT1(3) 1660160 52 27 48 12 34 6 0 11 1 0 0.0115 1.000 1.000 192 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(2), MBTPS1(2), SCAP(1), SREBF1(3), SREBF2(1) 542730 9 9 9 8 7 1 0 0 1 0 0.842 1.000 1.000 193 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 GCK(2), GFPT1(1), GNE(1), HEXA(2), HEXB(2), HK2(5), HK3(3), PGM3(1) 777172 17 12 17 8 11 2 0 4 0 0 0.452 1.000 1.000 194 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(1), SEC22B(1), SNAP25(2), TSNARE1(1), VAMP4(1), VAMP7(1) 757376 7 5 7 4 5 0 0 2 0 0 0.620 1.000 1.000 195 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(6), G6PD(1), GCLC(1), GCLM(2), GGT1(1), GPX3(1), GPX5(1), GPX6(6), GSS(2), GSTA1(2), GSTA2(2), GSTA5(1), GSTK1(1), GSTM2(2), GSTM3(2), GSTM4(2), GSTM5(1), IDH1(1), IDH2(1), MGST1(1), MGST2(1), OPLAH(2) 995275 40 20 39 16 28 1 2 4 5 0 0.0528 1.000 1.000 196 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP5(1), ACP6(3), ACPP(2), ALPI(2), ALPL(6), ALPP(2), ALPPL2(6), CMBL(1), CYP3A4(3), CYP3A43(4), CYP3A5(2), CYP3A7(7), DHRS1(2), DHRS2(1), DHRSX(2), PON1(4) 820325 48 23 46 21 35 1 2 3 7 0 0.128 1.000 1.000 197 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(9), CREB3(1), CREB5(2), DUSP9(2), EEF2K(4), MAPK1(2), MAPK3(1), MKNK1(1), NFKB1(4), RAP1A(1), RPS6KA1(3), SHC1(1), SOS1(3), SOS2(5), TRAF3(3) 1346509 42 23 39 14 29 4 2 3 4 0 0.0700 1.000 1.000 198 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(3), ARHGEF1(1), GNA12(1), GNAQ(1), MYL2(2), MYLK(11), PLCB1(18), PPP1R12B(3), PRKCA(5), ROCK1(2) 950256 47 23 44 19 41 2 2 1 1 0 0.124 1.000 1.000 199 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(6), CPT1A(1), LEP(1), LEPR(6), PRKAA1(1), PRKAA2(4), PRKAB1(1), PRKAG1(1), PRKAG2(4) 667196 25 17 24 10 18 0 0 0 7 0 0.341 1.000 1.000 200 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(9), ABCB11(10), ABCB4(6), ABCC1(4), ABCC3(4) 649809 33 17 33 16 21 4 1 3 4 0 0.129 1.000 1.000 201 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(1), ACO2(1), CS(1), DLD(1), FH(2), IDH1(1), IDH2(1), IDH3A(3), IDH3B(1), IDH3G(1), MDH2(2), PC(1), PCK1(8), SDHA(1) 946711 25 17 25 10 18 0 2 2 3 0 0.171 1.000 1.000 202 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA2(1), PSMA4(1), PSMA5(2), PSMA6(1), PSMB2(1), PSMB7(1), PSMD1(1), PSMD12(1), PSMD13(2), PSMD2(1) 737820 13 10 13 6 7 1 2 2 1 0 0.588 1.000 1.000 203 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 GTF2E1(1), GTF2E2(2), GTF2F2(1), GTF2H1(1), POLR1A(5), POLR1B(4), POLR2A(1), POLR2B(6), POLR2E(1), POLR3B(4), POLR3E(1), TAF9(1), TBP(2) 1603109 30 21 30 7 22 1 0 3 4 0 0.0342 1.000 1.000 204 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(1), ELK1(1), HRAS(2), MAPK3(1), NGFR(5), PIK3CA(3), PLCG1(1), RAF1(3), SHC1(1), SOS1(3) 870000 21 13 21 8 14 5 0 2 0 0 0.281 1.000 1.000 205 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(5), BST1(1), ENPP1(4), ENPP3(7), NADSYN1(2), NMNAT2(1), NMNAT3(2), NNMT(3), NNT(1), NT5C1A(2), NT5C1B(6), NT5C3(2), NT5E(1), NT5M(1), NUDT12(1), QPRT(2) 985731 41 18 41 16 28 3 2 2 6 0 0.137 1.000 1.000 206 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(3), ALOX12(2), ALOX15(4), ALOX5(4), CYP4F2(2), CYP4F3(4), EPX(4), GGT1(1), LPO(4), LTA4H(2), MPO(2), PLA2G1B(1), PLA2G2A(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), PRDX2(1), PRDX6(1), PTGDS(1), PTGIS(4), PTGS1(5), PTGS2(3), TBXAS1(6), TPO(11) 1276713 79 24 79 27 63 6 0 6 4 0 0.000874 1.000 1.000 207 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 GALNS(2), GLB1(2), GNS(1), HEXA(2), HEXB(2), IDS(5), IDUA(1), LCT(13), NAGLU(1) 654358 29 15 29 13 21 3 0 5 0 0 0.312 1.000 1.000 208 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(2), CNR1(1), CNR2(3), DNMT1(6), MTNR1A(2), PTAFR(1), PTGDR(2), PTGER2(1), PTGFR(6), PTGIR(1), TBXA2R(2) 509801 27 17 27 16 20 4 1 1 1 0 0.220 1.000 1.000 209 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), ELK1(1), EPO(2), EPOR(1), HRAS(2), JAK2(1), MAPK3(1), PLCG1(1), RAF1(3), SHC1(1), SOS1(3), STAT5A(1), STAT5B(1) 974049 19 12 19 8 9 4 2 3 1 0 0.343 1.000 1.000 210 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(2), CRK(1), CXCL12(1), CXCR4(1), GNAQ(1), HRAS(2), MAPK1(2), MAPK3(1), NFKB1(4), PIK3C2G(13), PIK3CA(3), PLCG1(1), PRKCA(5), PTK2(2), PTK2B(2), RAF1(3), RELA(1) 1253388 45 20 44 16 34 5 1 3 2 0 0.0608 1.000 1.000 211 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(3), HRAS(2), JAK2(1), MAPK3(1), RAF1(3), SHC1(1), SOS1(3), STAT5A(1), STAT5B(1) 803664 16 12 16 8 9 3 1 3 0 0 0.514 1.000 1.000 212 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(12), COL4A2(8), COL4A3(11), COL4A4(23), COL4A5(13), COL4A6(14), SLC23A1(1), SLC2A1(1), SLC2A3(2) 1134143 85 25 82 18 69 4 3 9 0 0 0.0762 1.000 1.000 213 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(3), F2(3), F2R(2), FGA(11), FGG(2), PLAT(1), PLG(11), SERPINB2(3), SERPINE1(2) 607801 38 21 37 15 31 1 2 2 2 0 0.281 1.000 1.000 214 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(1), CSF1(3), CSF3(2), HLA-DRA(3), HLA-DRB1(2), IFNA1(1), IFNB1(1), IL10(2), IL12B(1), IL15(1), IL1A(3), IL2(1), IL4(1), IL7(2), LTA(1) 600676 25 16 25 13 17 2 1 2 3 0 0.252 1.000 1.000 215 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(2), ATR(8), BRCA1(4), CDC25A(3), CDC25B(1), CDC25C(1), CDC34(1), CDKN1A(1), EP300(7), MYT1(4), PRKDC(6), RPS6KA1(3), TP53(11), WEE1(2), YWHAQ(2) 1914293 56 23 55 12 33 2 4 7 10 0 0.0106 1.000 1.000 216 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 EIF4A2(2), EIF4G1(7), EIF4G3(6), GHR(7), MAPK1(2), MAPK14(3), MAPK3(1), MKNK1(1), PABPC1(1), PDPK1(2), PIK3CA(3), PRKCA(5), PTEN(1), RPS6KB1(1) 1295086 42 20 41 15 27 6 2 2 5 0 0.197 1.000 1.000 217 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 DHCR7(2), FDPS(1), GGCX(1), HMGCR(3), HSD17B7(1), MVK(2), NSDHL(1) 879935 11 9 11 7 6 1 1 2 1 0 0.752 1.000 1.000 218 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(3), ACO1(1), ACO2(1), CLYBL(2), CS(1), DLD(1), FH(2), IDH1(1), IDH2(1), IDH3A(3), IDH3B(1), IDH3G(1), MDH2(2), OGDH(3), OGDHL(9), PC(1), PCK1(8), SDHA(1), SDHC(1), SDHD(1) 1371702 44 21 44 17 32 0 3 3 6 0 0.0568 1.000 1.000 219 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(4), CD3D(2), CXCR3(1), ETV5(1), IL12B(1), IL12RB1(6), IL18(2), IL18R1(6), JAK2(1), MAPK14(3), STAT4(7), TYK2(3) 846011 37 19 37 16 26 2 1 7 1 0 0.351 1.000 1.000 220 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(3), CA1(2), CA12(1), CA2(1), CA3(1), CA4(1), CA5B(1), CA8(1), CA9(2), CPS1(8), HAL(3) 859080 24 14 24 10 18 1 0 3 2 0 0.294 1.000 1.000 221 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(2), CALM1(1), GNAQ(1), HRAS(2), MAP2K3(2), MAPK1(2), MAPK14(3), MAPK3(1), PLCG1(1), PRKCA(5), PTK2B(2), RAC1(5), RAF1(3), SHC1(1), SOS1(3), SRC(1), SYT1(4) 1300187 39 21 36 13 29 6 0 3 1 0 0.0496 1.000 1.000 222 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(8), BIN1(3), CALM1(1), DNM1(3), EPN1(5), PICALM(1), SYNJ1(9), SYNJ2(6), SYT1(4) 978405 40 18 40 15 33 3 0 3 1 0 0.127 1.000 1.000 223 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(11), ACE2(1), AGT(2), AGTR1(2), AGTR2(1), ANPEP(6), CMA1(1), CPA3(4), CTSA(3), CTSG(1), ENPEP(7), LNPEP(1), MAS1(2), MME(6), NLN(1), REN(1), THOP1(5) 964326 55 22 55 26 40 5 3 2 5 0 0.172 1.000 1.000 224 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(14), C5(2), C6(18), C7(19), IL1A(3), ITGA4(13), ITGAL(8), ITGB1(2), ITGB2(6), SELP(10), SELPLG(2), VCAM1(4) 1123118 101 27 97 34 79 2 5 6 9 0 0.00343 1.000 1.000 225 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(1), ANXA2(1), ANXA4(1), ANXA6(2), EDN1(2), EDNRA(3), HSD11B1(1), HSD11B2(1), PLA2G4A(1), PTGDR(2), PTGDS(1), PTGER2(1), PTGFR(6), PTGIR(1), PTGIS(4), PTGS1(5), PTGS2(3), TBXAS1(6) 933985 42 21 42 21 34 4 0 1 3 0 0.146 1.000 1.000 226 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(1), CS(1), DLAT(1), DLD(1), FH(2), IDH2(1), IDH3A(3), IDH3B(1), IDH3G(1), MDH2(2), OGDH(3), PC(1), PDHA2(6), PDHX(1), PDK1(1), PDK4(3), PDP2(2), SDHA(1), SDHC(1), SDHD(1) 1301090 34 18 34 12 26 0 1 3 4 0 0.0909 1.000 1.000 227 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(5), ATIC(2), GART(2), MTR(2) 818304 11 9 10 6 10 0 1 0 0 0 0.523 1.000 1.000 228 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(3), CA1(2), CA12(1), CA2(1), CA3(1), CA4(1), CA5B(1), CA8(1), CA9(2), CPS1(8), GLUD2(2), HAL(3) 960774 26 16 26 11 18 1 1 3 3 0 0.323 1.000 1.000 229 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(9), ATM(2), BAX(2), CDKN1A(1), IGFBP3(1), NFKBIB(1), TP53(11) 951618 27 17 26 11 14 3 0 4 6 0 0.435 1.000 1.000 230 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(3), DIAPH1(5), FYN(1), GSN(2), HRAS(2), ITGA1(11), ITGB1(2), MAPK1(2), MAPK3(1), MYL2(2), MYLK(11), PIK3CA(3), PTK2(2), RAF1(3), ROCK1(2), SHC1(1), SRC(1), TLN1(5) 1701973 59 20 56 21 45 6 1 5 2 0 0.0491 1.000 1.000 231 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN1(1), ACTN2(6), ACTN3(3), CAPN1(1), ITGA1(11), ITGB1(2), ITGB3(2), PTK2(2), RAC1(5), SPTAN1(2), SRC(1), TLN1(5) 1284486 41 22 37 18 31 3 1 3 2 1 0.0797 1.000 1.000 232 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CASP2(1), CHUK(1), LTA(1), MAP2K3(2), MAP3K14(2), MAPK14(3), NFKB1(4), NFKBIA(1), RELA(1), TNFRSF1A(1) 1089418 17 14 17 9 13 1 0 2 1 0 0.556 1.000 1.000 233 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH5(1), ADH6(2), ADH7(1), ADHFE1(2), AKR1A1(1), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH3B1(1), ALDH3B2(2), ALDH7A1(1), ALDOA(1), ALDOB(4), BPGM(1), DLAT(1), DLD(1), ENO1(2), FBP1(1), G6PC(4), GALM(2), GAPDH(1), GAPDHS(1), GCK(2), HK2(5), HK3(3), LDHAL6B(1), LDHC(3), PDHA2(6), PFKL(2), PGAM2(1), PGK1(1), PGK2(4), PGM1(1), PGM3(1), PKLR(4), PKM2(1) 2653947 102 31 100 41 69 11 4 11 7 0 0.00859 1.000 1.000 234 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(7), AMY2A(2), AMY2B(2), ASCC3(6), ATP13A2(4), DDX18(1), DDX4(5), DDX41(2), DDX50(4), DDX51(2), DDX52(2), DDX54(1), DDX55(1), DDX56(1), ENPP1(4), ENPP3(7), ENTPD7(1), EP400(5), G6PC(4), GANC(1), GBA3(4), GBE1(2), GCK(2), GYS1(1), GYS2(5), HK2(5), HK3(3), IFIH1(2), MGAM(47), MOV10L1(4), NUDT5(1), PGM1(1), PGM3(1), PYGL(3), PYGM(5), RAD54B(1), RUVBL2(2), SETX(1), SI(23), SKIV2L2(1), SMARCA2(4), UGP2(1), UGT1A1(1), UGT1A10(7), UGT1A3(3), UGT1A4(3), UGT1A5(4), UGT1A6(2), UGT1A7(5), UGT1A8(2), UGT1A9(5), UGT2A1(9), UGT2A3(5), UGT2B10(9), UGT2B11(7), UGT2B15(3), UGT2B28(8), UGT2B4(9), UGT2B7(5), UXS1(1) 5601066 269 31 266 100 192 27 9 19 21 1 0.000326 1.000 1.000 235 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(2), ACTG1(1), COL11A1(10), COL11A2(5), COL17A1(12), COL1A1(9), COL1A2(9), COL2A1(5), COL3A1(18), COL4A1(12), COL4A2(8), COL4A4(23), COL4A6(14), COL5A1(25), COL5A2(10), COL5A3(16), COL6A2(9), COL6A3(11), COL6A6(12), COMP(1), DES(1), DSC1(12), DSC2(9), DSC3(12), DSG1(19), DSG2(5), DSG3(26), DSG4(17), FN1(5), GJA1(4), GJA10(5), GJA4(2), GJA5(2), GJA8(10), GJB1(1), GJB2(1), GJB3(1), GJB4(1), GJB5(5), GJC1(4), GJD2(2), IBSP(3), INA(1), ITGB4(4), KRT1(4), KRT10(1), KRT12(2), KRT13(1), KRT14(1), KRT15(4), KRT16(2), KRT17(3), KRT18(1), KRT2(8), KRT23(2), KRT24(2), KRT25(2), KRT27(2), KRT28(4), KRT3(7), KRT31(2), KRT32(4), KRT33A(2), KRT33B(1), KRT35(4), KRT36(3), KRT37(4), KRT38(2), KRT39(3), KRT4(5), KRT40(3), KRT5(2), KRT6A(5), KRT6B(2), KRT7(1), KRT71(6), KRT72(4), KRT73(5), KRT74(3), KRT75(2), KRT76(4), KRT77(2), KRT78(7), KRT8(1), KRT81(1), KRT82(3), KRT83(7), KRT84(3), KRT86(1), KRT9(6), LAMA1(15), LAMA2(22), LAMA3(23), LAMA4(2), LAMA5(10), LAMB1(5), LAMB2(5), LAMB3(7), LAMB4(12), LAMC1(3), LAMC2(6), LAMC3(2), LMNA(1), NES(7), PRPH(1), RELN(15), SPP1(2), THBS1(10), THBS2(2), THBS3(3), THBS4(4), TNC(12), TNN(11), TNR(20), TNXB(31), VIM(2), VTN(4), VWF(16) 11395989 761 31 749 324 580 54 20 58 49 0 0.000405 1.000 1.000 236 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(3), ABCA10(4), ABCA12(19), ABCA13(12), ABCA2(2), ABCA3(6), ABCA4(18), ABCA5(2), ABCA6(7), ABCA7(4), ABCA8(9), ABCA9(5), ABCB1(9), ABCB10(1), ABCB11(10), ABCB4(6), ABCB5(11), ABCB6(1), ABCB7(1), ABCB9(2), ABCC1(4), ABCC10(4), ABCC11(3), ABCC12(6), ABCC2(3), ABCC3(4), ABCC4(6), ABCC5(2), ABCC6(8), ABCC8(5), ABCC9(13), ABCD2(6), ABCD3(3), ABCG1(4), ABCG2(4), ABCG4(1), ABCG8(2), CFTR(14), TAP2(4) 5385770 228 31 226 129 144 23 14 21 26 0 0.105 1.000 1.000 237 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(1), AKT2(1), AKT3(2), ARRB2(3), ATF2(1), ATF4(2), BDNF(1), BRAF(9), CACNA1A(7), CACNA1B(6), CACNA1C(8), CACNA1D(8), CACNA1E(31), CACNA1F(7), CACNA1G(10), CACNA1H(5), CACNA1I(7), CACNA1S(13), CACNA2D1(3), CACNA2D2(5), CACNA2D3(14), CACNA2D4(6), CACNB1(3), CACNB2(4), CACNB3(1), CACNB4(4), CACNG1(2), CACNG2(3), CACNG3(4), CACNG4(1), CACNG5(1), CACNG6(2), CACNG7(1), CDC25B(1), CDC42(1), CHP(1), CHUK(1), CRK(1), DAXX(5), DDIT3(1), DUSP10(3), DUSP14(1), DUSP16(2), DUSP5(2), DUSP7(1), DUSP9(2), EGF(4), EGFR(6), ELK1(1), ELK4(2), FAS(1), FASLG(2), FGF12(3), FGF13(2), FGF14(2), FGF16(2), FGF21(2), FGF23(2), FGF3(3), FGF4(1), FGF5(2), FGF6(2), FGF8(1), FGF9(2), FGFR1(4), FGFR2(7), FGFR3(2), FLNA(5), FLNB(8), FLNC(20), GNA12(1), HRAS(2), IL1A(3), IL1B(1), IL1R1(3), IL1R2(1), KRAS(1), MAP2K3(2), MAP2K5(1), MAP2K7(2), MAP3K10(2), MAP3K12(1), MAP3K13(2), MAP3K14(2), MAP3K2(1), MAP3K3(1), MAP3K4(4), MAP3K5(7), MAP3K6(1), MAP3K7(1), MAP4K1(4), MAP4K3(1), MAP4K4(4), MAPK1(2), MAPK10(5), MAPK13(1), MAPK14(3), MAPK3(1), MAPK7(2), MAPK8IP2(3), MAPK8IP3(3), MAPK9(1), MAPKAPK2(2), MAPKAPK3(1), MAPT(3), MEF2C(1), MKNK1(1), MYC(2), NF1(38), NFATC2(1), NFATC4(6), NFKB1(4), NLK(2), NRAS(9), NTF3(1), NTRK1(2), NTRK2(5), PAK2(2), PDGFRA(9), PDGFRB(5), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), PPM1A(2), PPM1B(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKCA(5), PRKCG(4), PTPN5(4), PTPRR(5), RAC1(5), RAC2(1), RAF1(3), RAP1A(1), RAP1B(1), RAPGEF2(3), RASA2(6), RASGRF1(4), RASGRF2(9), RASGRP1(2), RASGRP2(2), RASGRP3(3), RASGRP4(4), RPS6KA1(3), RPS6KA5(1), RPS6KA6(3), SOS1(3), SOS2(5), STMN1(2), TAOK1(4), TAOK2(6), TGFBR2(2), TNFRSF1A(1), TP53(11), TRAF6(2), ZAK(3) 12910161 578 31 561 311 368 56 24 57 69 4 0.0781 1.000 1.000 238 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1B(1), ACVR2A(1), ACVR2B(1), BMP2(1), BMPR1B(2), BMPR2(1), CCL1(1), CCL2(1), CCL21(2), CCL24(1), CCL27(1), CCL7(3), CCL8(2), CCR1(3), CCR2(6), CCR3(3), CCR4(2), CCR5(4), CCR6(1), CCR8(1), CCR9(3), CD27(1), CD40(1), CD40LG(1), CSF1(3), CSF1R(3), CSF2RA(6), CSF2RB(3), CSF3(2), CSF3R(1), CX3CR1(3), CXCL12(1), CXCL5(1), CXCR3(1), CXCR4(1), CXCR6(1), EDA(1), EDA2R(1), EDAR(2), EGF(4), EGFR(6), EPO(2), EPOR(1), FAS(1), FASLG(2), FLT1(6), FLT3(7), FLT4(8), GDF5(3), GH1(1), GH2(3), GHR(7), HGF(4), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(1), IFNA21(2), IFNA4(1), IFNA5(1), IFNA8(1), IFNAR1(1), IFNB1(1), IFNGR1(2), IFNGR2(1), IL10(2), IL10RA(3), IL11RA(1), IL12B(1), IL12RB1(6), IL13RA1(2), IL15(1), IL15RA(2), IL17A(2), IL17B(2), IL17RA(3), IL17RB(1), IL18(2), IL18R1(6), IL18RAP(7), IL19(1), IL1A(3), IL1B(1), IL1R1(3), IL1R2(1), IL1RAP(2), IL2(1), IL20(3), IL20RA(3), IL21(1), IL21R(5), IL22RA1(2), IL25(1), IL26(1), IL28B(1), IL28RA(1), IL2RB(3), IL4(1), IL4R(3), IL5RA(7), IL6ST(1), IL7(2), IL7R(6), IL9(1), IL9R(1), INHBA(2), INHBB(2), INHBC(2), KDR(8), KIT(3), KITLG(1), LEP(1), LEPR(6), LIF(1), LIFR(5), LTA(1), MET(7), MPL(3), NGFR(5), OSM(3), OSMR(7), PDGFC(7), PDGFRA(9), PDGFRB(5), PLEKHO2(1), PPBP(1), PRLR(9), RELT(1), TGFBR2(2), TNFRSF10A(2), TNFRSF10C(1), TNFRSF10D(4), TNFRSF11A(1), TNFRSF11B(3), TNFRSF13B(1), TNFRSF14(2), TNFRSF17(1), TNFRSF19(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(3), TNFRSF4(2), TNFRSF8(1), TNFRSF9(2), TNFSF10(1), TNFSF11(1), TNFSF12(1), TNFSF14(4), TNFSF15(1), TNFSF18(3), TNFSF4(1), TNFSF8(2), TPO(11), VEGFA(2), VEGFC(7), XCR1(1) 8046304 393 31 389 224 272 24 12 42 43 0 0.375 1.000 1.000 239 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(1), CALML3(3), CDS1(2), CDS2(1), DGKB(6), DGKD(2), DGKE(1), DGKG(2), DGKH(6), DGKI(6), DGKZ(1), IMPA2(1), INPP1(1), INPP4B(1), INPP5A(2), INPP5B(2), INPP5D(13), INPPL1(7), ITPK1(2), ITPKB(2), ITPR1(8), ITPR2(4), ITPR3(1), OCRL(2), PI4KA(4), PI4KB(2), PIK3C2A(1), PIK3C2B(2), PIK3C2G(13), PIK3C3(1), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PIP4K2A(1), PIP4K2B(1), PIP5K1A(2), PIP5K1B(4), PIP5K1C(1), PLCB1(18), PLCB2(2), PLCB4(21), PLCD1(1), PLCE1(15), PLCG1(1), PLCG2(11), PLCZ1(7), PRKCA(5), PRKCG(4), PTEN(1), SYNJ1(9), SYNJ2(6) 5652725 227 31 223 112 172 15 7 14 18 1 0.0459 1.000 1.000 240 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(9), CPEB1(2), EGFR(6), ERBB2(4), ERBB4(13), ETS1(2), ETS2(2), ETV6(1), FMN2(20), KRAS(1), MAPK1(2), MAPK3(1), NOTCH1(1), NOTCH2(4), NOTCH3(5), NOTCH4(14), PIWIL1(3), PIWIL2(5), PIWIL3(4), PIWIL4(3), RAF1(3), SOS1(3), SOS2(5), SPIRE1(1), SPIRE2(2) 2396634 116 31 112 49 81 9 6 15 5 0 0.179 1.000 1.000 241 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(2), ACTG1(1), ACTN1(1), ACTN2(6), ACTN3(3), AKT2(1), AKT3(2), ARHGAP5(3), BCAR1(2), BIRC3(1), BRAF(9), CAPN2(1), CAV1(1), CCND1(1), CCND2(1), CDC42(1), COL11A1(10), COL11A2(5), COL1A1(9), COL1A2(9), COL2A1(5), COL3A1(18), COL4A1(12), COL4A2(8), COL4A4(23), COL4A6(14), COL5A1(25), COL5A2(10), COL5A3(16), COL6A2(9), COL6A3(11), COL6A6(12), COMP(1), CRK(1), CTNNB1(3), DIAPH1(5), DOCK1(5), EGF(4), EGFR(6), ELK1(1), ERBB2(4), FARP2(1), FLNA(5), FLNB(8), FLNC(20), FLT1(6), FN1(5), FYN(1), GRLF1(5), GSK3B(1), HGF(4), HRAS(2), IBSP(3), IGF1R(1), ITGA1(11), ITGA10(2), ITGA11(3), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(13), ITGA5(8), ITGA7(3), ITGA8(7), ITGA9(3), ITGAV(3), ITGB1(2), ITGB3(2), ITGB4(4), ITGB5(2), ITGB6(2), ITGB7(2), ITGB8(8), KDR(8), LAMA1(15), LAMA2(22), LAMA3(23), LAMA4(2), LAMA5(10), LAMB1(5), LAMB2(5), LAMB3(7), LAMB4(12), LAMC1(3), LAMC2(6), LAMC3(2), MAPK1(2), MAPK10(5), MAPK3(1), MAPK9(1), MET(7), MYL2(2), MYL5(1), MYL7(1), MYLK(11), MYLK2(2), MYLPF(1), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PAK7(15), PARVB(1), PARVG(1), PDGFC(7), PDGFD(2), PDGFRA(9), PDGFRB(5), PDPK1(2), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PIP5K1C(1), PPP1CB(3), PPP1CC(1), PPP1R12A(2), PRKCA(5), PRKCG(4), PTEN(1), PTK2(2), RAC1(5), RAC2(1), RAF1(3), RAP1A(1), RAP1B(1), RAPGEF1(3), RELN(15), ROCK1(2), ROCK2(4), SHC1(1), SHC2(3), SHC3(1), SHC4(2), SOS1(3), SOS2(5), SPP1(2), SRC(1), THBS1(10), THBS2(2), THBS3(3), THBS4(4), TLN1(5), TLN2(6), TNC(12), TNN(11), TNR(20), TNXB(31), VASP(2), VAV1(2), VAV3(4), VCL(2), VEGFA(2), VEGFC(7), VTN(4), VWF(16), ZYX(2) 16939801 842 31 824 365 629 59 23 69 61 1 0.000631 1.000 1.000 242 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(2), CD36(2), CD44(1), COL11A1(10), COL11A2(5), COL1A1(9), COL1A2(9), COL2A1(5), COL3A1(18), COL4A1(12), COL4A2(8), COL4A4(23), COL4A6(14), COL5A1(25), COL5A2(10), COL5A3(16), COL6A2(9), COL6A3(11), COL6A6(12), DAG1(2), FN1(5), FNDC1(11), FNDC3A(1), FNDC4(1), FNDC5(1), GP5(1), GP6(2), GP9(1), HMMR(3), HSPG2(8), IBSP(3), ITGA1(11), ITGA10(2), ITGA11(3), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(13), ITGA5(8), ITGA7(3), ITGA8(7), ITGA9(3), ITGAV(3), ITGB1(2), ITGB3(2), ITGB4(4), ITGB5(2), ITGB6(2), ITGB7(2), ITGB8(8), LAMA1(15), LAMA2(22), LAMA3(23), LAMA4(2), LAMA5(10), LAMB1(5), LAMB2(5), LAMB3(7), LAMB4(12), LAMC1(3), LAMC2(6), LAMC3(2), RELN(15), SPP1(2), SV2A(7), SV2B(5), SV2C(6), THBS1(10), THBS2(2), THBS3(3), THBS4(4), TNC(12), TNN(11), TNR(20), TNXB(31), VTN(4), VWF(16) 10236254 579 31 572 234 450 29 17 47 36 0 0.00622 1.000 1.000 243 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 CADM1(2), CADM3(7), CD2(11), CD22(7), CD226(1), CD276(1), CD28(1), CD34(1), CD4(1), CD40(1), CD40LG(1), CD6(1), CD86(8), CD8B(1), CDH15(2), CDH2(2), CDH4(13), CDH5(4), CLDN1(1), CLDN10(1), CLDN11(3), CLDN14(1), CLDN16(1), CLDN17(1), CLDN18(3), CLDN2(2), CLDN20(1), CLDN4(3), CLDN6(1), CLDN7(1), CNTN1(5), CNTN2(3), CNTNAP1(3), CNTNAP2(29), CTLA4(1), HLA-A(2), HLA-B(2), HLA-DMA(1), HLA-DMB(3), HLA-DOA(1), HLA-DQA1(3), HLA-DQA2(4), HLA-DQB1(3), HLA-DRA(3), HLA-DRB1(2), HLA-DRB5(1), HLA-F(1), HLA-G(1), ICOS(1), ITGA4(13), ITGA8(7), ITGA9(3), ITGAL(8), ITGAM(9), ITGAV(3), ITGB1(2), ITGB2(6), ITGB7(2), ITGB8(8), JAM2(3), L1CAM(3), MAG(2), MPZ(1), MPZL1(1), NCAM1(3), NCAM2(2), NEO1(4), NFASC(10), NLGN1(2), NLGN2(1), NLGN3(1), NRCAM(4), NRXN1(11), NRXN2(2), NRXN3(8), OCLN(1), PTPRC(4), PTPRF(11), PTPRM(1), PVR(1), PVRL1(3), PVRL2(2), PVRL3(4), SELE(8), SELL(3), SELP(10), SELPLG(2), SIGLEC1(5), SPN(1), VCAM1(4), VCAN(15) 6677694 347 31 341 152 243 27 15 35 27 0 0.00276 1.000 1.000 244 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(2), ACTG1(1), ACTN1(1), ACTN2(6), ACTN3(3), AKT2(1), AKT3(2), AMOTL1(1), ASH1L(6), CDC42(1), CDK4(2), CGN(2), CLDN1(1), CLDN10(1), CLDN11(3), CLDN14(1), CLDN16(1), CLDN17(1), CLDN18(3), CLDN2(2), CLDN20(1), CLDN4(3), CLDN6(1), CLDN7(1), CSNK2A1(1), CTNNA1(2), CTNNA2(8), CTNNA3(13), CTNNB1(3), EPB41(3), EPB41L1(2), EPB41L2(4), EXOC4(3), GNAI2(4), HCLS1(3), HRAS(2), IGSF5(2), INADL(8), JAM2(3), KRAS(1), LLGL1(1), LLGL2(6), MAGI1(7), MAGI2(5), MLLT4(2), MPDZ(4), MYH1(29), MYH10(6), MYH11(11), MYH13(9), MYH14(5), MYH15(15), MYH2(22), MYH3(7), MYH4(27), MYH6(13), MYH7(10), MYH7B(3), MYH8(18), MYH9(1), MYL2(2), MYL5(1), MYL7(1), MYLPF(1), NRAS(9), OCLN(1), PARD3(6), PARD6A(1), PARD6B(1), PARD6G(2), PPP2CB(1), PPP2R1B(2), PPP2R2A(2), PPP2R2B(1), PPP2R2C(2), PPP2R3A(3), PPP2R3B(2), PRKCA(5), PRKCD(2), PRKCE(2), PRKCG(4), PRKCH(2), PRKCI(2), PRKCQ(5), PRKCZ(1), PTEN(1), SPTAN1(2), SRC(1), SYMPK(1), TJP1(2), TJP2(4), TJP3(5), VAPA(1), ZAK(3) 8807514 391 31 379 246 270 37 13 38 32 1 0.516 1.000 1.000 245 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT2(1), AKT3(2), CBL(2), CBLB(5), CBLC(1), CCND1(1), CCND2(1), CREBBP(4), CSF2RA(6), CSF2RB(3), CSF3(2), CSF3R(1), EP300(7), EPO(2), EPOR(1), GH1(1), GH2(3), GHR(7), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(1), IFNA21(2), IFNA4(1), IFNA5(1), IFNA8(1), IFNAR1(1), IFNB1(1), IFNGR1(2), IFNGR2(1), IL10(2), IL10RA(3), IL11RA(1), IL12B(1), IL12RB1(6), IL13RA1(2), IL13RA2(1), IL15(1), IL15RA(2), IL19(1), IL2(1), IL20(3), IL20RA(3), IL21(1), IL21R(5), IL22RA1(2), IL26(1), IL28B(1), IL28RA(1), IL2RB(3), IL4(1), IL4R(3), IL5RA(7), IL6ST(1), IL7(2), IL7R(6), IL9(1), IL9R(1), JAK1(1), JAK2(1), LEP(1), LEPR(6), LIF(1), LIFR(5), MPL(3), MYC(2), OSM(3), OSMR(7), PIAS2(1), PIAS3(3), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PRLR(9), PTPN11(5), SOCS4(2), SOCS5(1), SOCS7(3), SOS1(3), SOS2(5), SPRED1(2), SPRY1(1), SPRY3(3), STAT1(3), STAT3(1), STAT4(7), STAT5A(1), STAT5B(1), STAT6(4), TPO(11), TYK2(3) 6634934 243 31 239 122 158 21 9 27 28 0 0.328 1.000 1.000 246 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(1), ACTN1(1), AKT2(1), AKT3(2), BCAR1(2), BRAF(9), CAV1(1), CDC42(1), CDKN2A(6), CRK(1), CSE1L(1), DOCK1(5), EPHB2(8), FYN(1), GRB7(1), GRLF1(5), ITGA1(11), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(13), ITGA5(8), ITGA7(3), ITGA8(7), ITGA9(3), ITGB3BP(1), MAP2K7(2), MAP3K11(3), MAPK1(2), MAPK10(5), MAPK8IP2(3), MAPK8IP3(3), MAPK9(1), MYLK(11), MYLK2(2), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PAK7(15), PIK3CA(3), PIK3CB(2), PKLR(4), PLCG1(1), PLCG2(11), PTEN(1), PTK2(2), RAF1(3), ROCK1(2), ROCK2(4), SHC1(1), SOS1(3), SOS2(5), SRC(1), TLN1(5), TLN2(6), VASP(2), WAS(2), ZYX(2) 5564012 216 31 205 90 154 18 7 19 18 0 0.00498 1.000 1.000 247 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(7), AMY2A(2), AMY2B(2), ENPP1(4), ENPP3(7), G6PC(4), GBA3(4), GBE1(2), GCK(2), GYS1(1), GYS2(5), HK2(5), HK3(3), MGAM(47), PGM1(1), PGM3(1), PYGL(3), PYGM(5), SI(23), UCHL1(2), UCHL3(1), UGT1A1(1), UGT1A10(7), UGT1A3(3), UGT1A4(3), UGT1A5(4), UGT1A6(2), UGT1A7(5), UGT1A8(2), UGT1A9(5), UGT2B15(3), UGT2B4(9), UXS1(1) 2587485 176 31 172 67 127 20 5 12 11 1 0.00278 1.000 1.000 248 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(6), ADCY2(1), ADCY3(1), ADCY4(1), ADCY5(5), ADCY6(1), ADCY7(2), ADCY8(17), ADCY9(1), ADRA1A(2), ADRA1B(2), ADRA1D(1), ADRB1(3), ANXA6(2), ARRB2(3), ATP1A4(1), ATP2A2(4), ATP2A3(4), ATP2B1(4), ATP2B2(6), ATP2B3(2), CACNA1A(7), CACNA1B(6), CACNA1C(8), CACNA1D(8), CACNA1E(31), CACNA1S(13), CACNB1(3), CACNB3(1), CALM1(1), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CAMK4(3), CASQ2(2), CHRM1(2), CHRM2(8), CHRM3(4), CHRM4(2), CHRM5(2), GJA1(4), GJA4(2), GJA5(2), GJB1(1), GJB2(1), GJB3(1), GJB4(1), GJB5(5), GNA11(1), GNAI2(4), GNAQ(1), GNAZ(3), GNB3(2), GNB4(3), GNB5(1), GNG2(1), GRK4(2), GRK5(2), ITPR1(8), ITPR2(4), ITPR3(1), KCNB1(10), KCNJ3(8), KCNJ5(3), MIB1(3), NME7(2), PKIG(1), PRKACA(1), PRKACB(1), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(2), PRKCG(4), PRKCH(2), PRKCQ(5), PRKCZ(1), PRKD1(1), RGS11(1), RGS18(3), RGS3(3), RGS4(1), RGS6(7), RGS7(8), RGS9(3), RYR1(18), RYR2(22), RYR3(22), SFN(1), SLC8A1(12), SLC8A3(7), USP5(2), YWHAQ(2) 8507182 392 30 386 291 268 44 20 31 29 0 0.837 1.000 1.000 249 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(6), ADCY2(1), ADCY3(1), ADCY4(1), ADCY5(5), ADCY6(1), ADCY7(2), ADCY8(17), ADCY9(1), AKAP1(2), AKAP10(1), AKAP11(3), AKAP12(1), AKAP3(5), AKAP4(5), AKAP6(10), AKAP7(1), AKAP8(1), AKAP9(9), ARHGEF1(1), CALM1(1), GNA11(1), GNA12(1), GNA14(1), GNA15(2), GNAI2(4), GNAQ(1), GNAZ(3), GNB3(2), GNB5(1), GNGT2(2), HRAS(2), ITPR1(8), KCNJ3(8), KRAS(1), NRAS(9), PDE1A(10), PDE1B(1), PDE1C(13), PDE4A(2), PDE4B(2), PDE4C(2), PDE4D(1), PDE7B(4), PDE8B(10), PRKACA(1), PRKACB(1), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(2), PRKCG(4), PRKCH(2), PRKCI(2), PRKCQ(5), PRKCZ(1), PRKD1(1), SLC9A1(1), USP5(2) 5335823 198 30 191 130 136 19 10 22 11 0 0.815 1.000 1.000 250 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(1), ADORA3(4), ADRA1A(2), ADRA1B(2), ADRA1D(1), ADRA2A(1), ADRB1(3), AGTR1(2), AGTR2(1), AVPR1A(3), AVPR1B(3), BDKRB1(1), BDKRB2(3), BRS3(1), CCBP2(3), CCKAR(4), CCKBR(2), CCR1(3), CCR10(1), CCR2(6), CCR3(3), CCR4(2), CCR5(4), CCR6(1), CCR8(1), CCR9(3), CCRL2(1), CHML(1), CHRM1(2), CHRM2(8), CHRM3(4), CHRM4(2), CHRM5(2), CMKLR1(5), CNR1(1), CNR2(3), CX3CR1(3), CXCR3(1), CXCR4(1), DRD1(1), DRD2(2), DRD3(3), DRD4(1), DRD5(6), EDNRA(3), F2R(2), F2RL1(2), F2RL2(3), F2RL3(1), FPR1(4), FSHR(3), GALR3(1), GALT(1), GHSR(1), GNB2L1(1), GPR17(1), GPR174(4), GPR3(1), GPR35(1), GPR37(3), GPR37L1(1), GPR4(3), GPR50(5), GPR6(3), GPR63(2), GPR77(3), GPR83(5), GPR85(1), GPR87(1), GRPR(1), HCRTR1(1), HCRTR2(10), HRH1(4), HRH3(3), HTR1A(2), HTR1D(3), HTR1E(1), HTR1F(5), HTR2A(2), HTR2B(2), HTR2C(3), HTR4(5), HTR5A(5), HTR6(1), HTR7(3), LHCGR(9), MAS1(2), MC3R(2), MC5R(1), MTNR1A(2), NMBR(1), NMUR2(6), NPY1R(6), NPY2R(3), NPY5R(2), NTSR1(2), OPN3(1), OPRK1(10), OPRL1(2), OR10A5(1), OR11A1(1), OR1C1(2), OR1Q1(2), OR2H1(2), OR5V1(4), OR7C1(1), OR8B8(4), OXTR(2), P2RY1(1), P2RY10(3), P2RY12(2), P2RY14(1), P2RY2(5), PPYR1(5), PTAFR(1), PTGDR(2), PTGER2(1), PTGFR(6), PTGIR(1), RGR(1), RRH(1), SSTR1(2), SSTR2(2), SSTR3(2), SSTR4(1), SUCNR1(2), TBXA2R(2), TRHR(3) 5514166 327 30 325 240 230 29 8 36 24 0 0.0389 1.000 1.000 251 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(6), ADCY2(1), ADCY3(1), ADCY4(1), ADCY5(5), ADCY6(1), ADCY7(2), ADCY8(17), ADCY9(1), ADK(1), ADSSL1(1), AK2(2), AK5(1), AK7(7), ALLC(2), AMPD1(7), AMPD3(2), ATIC(2), CANT1(4), DGUOK(2), ENPP1(4), ENPP3(7), ENTPD1(2), ENTPD2(1), ENTPD4(1), ENTPD6(1), GART(2), GDA(4), GMPS(1), GUCY1A2(6), GUCY1A3(10), GUCY1B3(1), GUCY2C(10), GUCY2D(4), GUCY2F(7), NME6(2), NME7(2), NPR1(1), NPR2(2), NT5C1A(2), NT5C1B(6), NT5C3(2), NT5E(1), NT5M(1), NUDT5(1), NUDT9(1), PAICS(1), PAPSS2(2), PDE10A(2), PDE11A(4), PDE1A(10), PDE1C(13), PDE2A(1), PDE3B(1), PDE4A(2), PDE4B(2), PDE4C(2), PDE4D(1), PDE5A(3), PDE7B(4), PDE8B(10), PDE9A(3), PFAS(2), PKLR(4), PKM2(1), POLA2(2), POLD1(1), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLR1A(5), POLR1B(4), POLR2A(1), POLR2B(6), POLR2E(1), POLR3A(2), POLR3B(4), POLR3G(1), POLR3GL(1), PRIM2(3), PRPS1L1(4), PRPS2(1), PRUNE(1), RRM1(1), XDH(13) 7452669 277 30 272 139 188 19 17 31 22 0 0.0735 1.000 1.000 252 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH5(1), ADH6(2), ADH7(1), ADHFE1(2), AKR1C2(1), AKR1C3(3), AKR1C4(4), ALDH1A3(1), ALDH3A1(2), ALDH3B1(1), ALDH3B2(2), CYP1A1(2), CYP1A2(2), CYP1B1(1), CYP2B6(5), CYP2C18(10), CYP2C19(7), CYP2C8(11), CYP2C9(12), CYP2E1(5), CYP2F1(3), CYP2S1(2), CYP3A4(3), CYP3A43(4), CYP3A5(2), CYP3A7(7), DHDH(2), EPHX1(1), GSTA1(2), GSTA2(2), GSTA5(1), GSTK1(1), GSTM2(2), GSTM3(2), GSTM4(2), GSTM5(1), MGST1(1), MGST2(1), UGT1A1(1), UGT1A10(7), UGT1A3(3), UGT1A4(3), UGT1A5(4), UGT1A6(2), UGT1A7(5), UGT1A8(2), UGT1A9(5), UGT2A1(9), UGT2A3(5), UGT2B10(9), UGT2B11(7), UGT2B15(3), UGT2B28(8), UGT2B4(9), UGT2B7(5) 2596722 229 30 224 90 162 20 10 15 21 1 0.000197 1.000 1.000 253 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 ALG10(1), ALG10B(1), ALG13(2), ALG2(2), ALG3(1), ALG6(1), B3GNT7(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), C1GALT1(1), C1GALT1C1(1), CHST1(2), CHST11(2), CHST12(2), CHST13(1), CHST2(3), CHST4(3), CHST6(2), CHSY1(6), DAD1(1), EXT1(1), EXT2(1), EXTL3(3), FUT8(2), GALNT1(1), GALNT11(1), GALNT12(1), GALNT13(8), GALNT14(8), GALNT2(1), GALNT3(1), GALNT4(2), GALNT5(3), GALNT6(4), GALNT7(2), GALNT8(5), GALNT9(1), GALNTL1(2), GALNTL2(10), GALNTL4(3), GALNTL5(2), GCNT1(2), GCNT4(3), HS2ST1(1), HS3ST1(4), HS3ST2(1), HS3ST3A1(2), HS3ST5(3), HS6ST1(1), HS6ST2(1), HS6ST3(2), MAN1A1(3), MAN1B1(1), MAN1C1(3), MGAT1(1), MGAT3(4), MGAT4A(2), MGAT5(1), MGAT5B(3), NDST1(1), NDST2(1), NDST3(7), NDST4(12), OGT(2), RPN2(1), ST3GAL1(2), ST6GAL1(1), ST6GALNAC1(1), STT3B(1), WBSCR17(11), XYLT1(5) 4978490 181 30 179 110 125 18 11 17 10 0 0.620 1.000 1.000 254 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(6), ADCY2(1), ADCY3(1), ADCY4(1), ADCY7(2), ADCY8(17), ADCY9(1), ADRA1A(2), ADRA1B(2), ADRA1D(1), ADRB1(3), AGTR1(2), ATP2A1(3), ATP2A2(4), ATP2A3(4), ATP2B1(4), ATP2B2(6), ATP2B3(2), ATP2B4(6), AVPR1A(3), AVPR1B(3), BDKRB1(1), BDKRB2(3), BST1(1), CACNA1A(7), CACNA1B(6), CACNA1C(8), CACNA1D(8), CACNA1E(31), CACNA1F(7), CACNA1G(10), CACNA1H(5), CACNA1I(7), CACNA1S(13), CALM1(1), CALML3(3), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CAMK4(3), CCKAR(4), CCKBR(2), CHP(1), CHRM1(2), CHRM2(8), CHRM3(4), CHRM5(2), CYSLTR2(1), DRD1(1), EDNRA(3), EGFR(6), ERBB2(4), ERBB3(1), ERBB4(13), F2R(2), GNA11(1), GNA14(1), GNA15(2), GNAQ(1), GNAS(4), GRIN1(3), GRIN2A(30), GRIN2C(2), GRIN2D(2), GRM1(7), GRM5(4), GRPR(1), HRH1(4), HTR2A(2), HTR2B(2), HTR2C(3), HTR4(5), HTR5A(5), HTR6(1), HTR7(3), ITPKB(2), ITPR1(8), ITPR2(4), ITPR3(1), LHCGR(9), MYLK(11), MYLK2(2), NOS1(20), NOS3(2), NTSR1(2), OXTR(2), P2RX1(2), P2RX3(2), P2RX4(1), P2RX5(2), PDE1A(10), PDE1B(1), PDE1C(13), PDGFRA(9), PDGFRB(5), PHKA1(8), PHKA2(2), PHKB(1), PHKG2(1), PLCB1(18), PLCB2(2), PLCB4(21), PLCD1(1), PLCE1(15), PLCG1(1), PLCG2(11), PLCZ1(7), PPP3R2(1), PRKACA(1), PRKACB(1), PRKCA(5), PRKCG(4), PTAFR(1), PTGER3(1), PTGFR(6), PTK2B(2), RYR1(18), RYR2(22), RYR3(22), SLC8A1(12), SLC8A2(3), SLC8A3(7), SPHK2(3), TACR1(1), TACR2(2), TACR3(6), TBXA2R(2), TNNC1(1), TNNC2(1), TRHR(3), TRPC1(1), VDAC1(1), VDAC3(1) 12173612 655 30 644 462 480 48 22 52 52 1 0.507 1.000 1.000 255 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(3), ADORA1(1), ADORA3(4), ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2B(1), ADRB1(3), AGTR1(2), AGTR2(1), AVPR1A(3), AVPR1B(3), BDKRB1(1), BDKRB2(3), BRS3(1), C5AR1(2), CALCR(6), CALCRL(6), CCKAR(4), CCKBR(2), CHRM1(2), CHRM2(8), CHRM3(4), CHRM4(2), CHRM5(2), CNR1(1), CNR2(3), CRHR1(2), CRHR2(1), CTSG(1), CYSLTR2(1), DRD1(1), DRD2(2), DRD3(3), DRD4(1), DRD5(6), EDNRA(3), F2(3), F2R(2), F2RL1(2), F2RL2(3), F2RL3(1), FPR1(4), FSHR(3), GABBR1(3), GABBR2(1), GABRA1(6), GABRA2(4), GABRA3(6), GABRA4(3), GABRA5(1), GABRA6(8), GABRB1(5), GABRB2(5), GABRB3(6), GABRD(2), GABRE(5), GABRG1(8), GABRG2(2), GABRG3(2), GABRP(5), GABRQ(3), GABRR2(1), GALR3(1), GH1(1), GH2(3), GHR(7), GHSR(1), GIPR(1), GLP1R(3), GLP2R(7), GLRA1(1), GLRA3(8), GLRB(10), GPR156(4), GPR35(1), GPR50(5), GPR63(2), GPR83(5), GRIA1(13), GRIA2(5), GRIA3(10), GRIA4(6), GRID1(8), GRID2(16), GRIK1(4), GRIK2(6), GRIK3(6), GRIK4(2), GRIK5(3), GRIN1(3), GRIN2A(30), GRIN2B(11), GRIN2C(2), GRIN2D(2), GRIN3A(13), GRIN3B(1), GRM1(7), GRM2(3), GRM3(18), GRM4(8), GRM5(4), GRM6(11), GRM7(9), GRM8(12), GRPR(1), GZMA(5), HCRTR1(1), HCRTR2(10), HRH1(4), HRH3(3), HRH4(1), HTR1A(2), HTR1D(3), HTR1E(1), HTR1F(5), HTR2A(2), HTR2B(2), HTR2C(3), HTR4(5), HTR5A(5), HTR6(1), HTR7(3), LEP(1), LEPR(6), LHCGR(9), MAS1(2), MC2R(4), MC3R(2), MC5R(1), MCHR2(3), MTNR1A(2), NMBR(1), NMUR2(6), NPBWR2(3), NPFFR2(3), NPY1R(6), NPY2R(3), NPY5R(2), NR3C1(3), NTSR1(2), OPRK1(10), OPRL1(2), OXTR(2), P2RX1(2), P2RX3(2), P2RX4(1), P2RX5(2), P2RY1(1), P2RY10(3), P2RY14(1), P2RY2(5), P2RY8(1), PARD3(6), PPYR1(5), PRLR(9), PRSS1(6), PRSS3(1), PTAFR(1), PTGDR(2), PTGER2(1), PTGER3(1), PTGFR(6), PTGIR(1), PTH2R(4), RXFP1(5), RXFP2(3), SCTR(3), SSTR1(2), SSTR2(2), SSTR3(2), SSTR4(1), TAAR1(2), TAAR2(3), TAAR6(6), TAAR8(2), TAAR9(1), TACR1(1), TACR2(2), TACR3(6), TBXA2R(2), THRB(4), TRHR(3), TRPV1(2), TSHB(3), TSHR(1), VIPR1(1), VIPR2(3) 10024699 712 30 690 426 513 56 27 57 58 1 0.000119 1.000 1.000 256 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(5), APC2(3), AXIN1(4), AXIN2(2), BTRC(3), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CCND1(1), CCND2(1), CER1(6), CHD8(4), CHP(1), CREBBP(4), CSNK1A1L(1), CSNK1E(1), CSNK2A1(1), CTNNB1(3), CUL1(2), CXXC4(1), DAAM1(1), DAAM2(1), DKK2(4), DKK4(1), DVL3(1), EP300(7), FBXW11(2), FZD1(1), FZD10(1), FZD2(2), FZD4(1), FZD6(1), FZD7(3), GSK3B(1), LEF1(1), LRP5(7), LRP6(2), MAP3K7(1), MAPK10(5), MAPK9(1), MMP7(1), MYC(2), NFAT5(2), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), NKD1(1), NKD2(1), NLK(2), PLCB1(18), PLCB2(2), PLCB4(21), PPARD(1), PPP2CB(1), PPP2R1B(2), PPP2R2A(2), PPP2R2B(1), PPP2R2C(2), PPP3R2(1), PRICKLE1(2), PRICKLE2(1), PRKACA(1), PRKACB(1), PRKCA(5), PRKCG(4), RAC1(5), RAC2(1), ROCK1(2), ROCK2(4), RUVBL1(1), SENP2(3), SFRP1(1), SFRP2(3), SFRP4(1), SMAD2(1), SMAD3(1), SOX17(4), TBL1X(1), TBL1XR1(1), TBL1Y(2), TCF7L1(1), TP53(11), VANGL1(2), VANGL2(1), WIF1(4), WNT10A(3), WNT10B(1), WNT11(1), WNT2(2), WNT3(1), WNT3A(2), WNT4(2), WNT5A(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(3), WNT9B(2) 7342435 256 30 250 112 175 19 13 25 23 1 0.0237 1.000 1.000 257 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(1), ABLIM1(4), ABLIM2(2), ABLIM3(2), ARHGEF12(4), CDC42(1), CHP(1), CXCL12(1), CXCR4(1), DCC(28), DPYSL5(2), EFNA2(1), EFNA5(1), EFNB3(1), EPHA1(3), EPHA2(5), EPHA3(8), EPHA4(5), EPHA5(2), EPHA6(24), EPHA7(17), EPHA8(4), EPHB1(8), EPHB2(8), EPHB3(5), EPHB4(5), EPHB6(4), FES(1), FYN(1), GNAI2(4), GSK3B(1), HRAS(2), ITGB1(2), KRAS(1), L1CAM(3), LIMK1(1), LIMK2(1), LRRC4C(10), MAPK1(2), MAPK3(1), MET(7), NCK2(1), NFAT5(2), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), NGEF(4), NRAS(9), NRP1(4), NTN4(4), NTNG1(4), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PAK7(15), PLXNA1(6), PLXNA2(2), PLXNB1(4), PLXNB2(6), PLXNB3(1), PLXNC1(3), PPP3R2(1), PTK2(2), RAC1(5), RAC2(1), RGS3(3), RHOD(1), RND1(1), ROBO1(3), ROBO2(7), ROBO3(5), ROCK1(2), ROCK2(4), SEMA3A(3), SEMA3B(2), SEMA3D(6), SEMA3E(5), SEMA3F(1), SEMA3G(4), SEMA4A(1), SEMA4B(1), SEMA4C(3), SEMA4D(3), SEMA4F(2), SEMA4G(1), SEMA5A(6), SEMA5B(2), SEMA6A(2), SEMA6B(2), SEMA6C(2), SEMA6D(1), SEMA7A(2), SLIT1(5), SLIT2(11), SLIT3(15), SRGAP1(4), SRGAP2(2), SRGAP3(10), UNC5A(4), UNC5B(7), UNC5C(3), UNC5D(7) 8909012 425 30 406 216 296 28 12 49 40 0 0.0498 1.000 1.000 258 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(6), ADCY2(1), ADCY3(1), ADCY4(1), ADCY5(5), ADCY6(1), ADCY7(2), ADCY8(17), ADCY9(1), ADRB1(3), DRD1(1), DRD2(2), EGF(4), EGFR(6), GJA1(4), GJD2(2), GNA11(1), GNAI2(4), GNAQ(1), GNAS(4), GRM1(7), GRM5(4), GUCY1A2(6), GUCY1A3(10), GUCY1B3(1), GUCY2C(10), GUCY2D(4), GUCY2F(7), HRAS(2), HTR2A(2), HTR2B(2), HTR2C(3), ITPR1(8), ITPR2(4), ITPR3(1), KRAS(1), MAP2K5(1), MAP3K2(1), MAPK1(2), MAPK3(1), MAPK7(2), NPR1(1), NPR2(2), NRAS(9), PDGFC(7), PDGFD(2), PDGFRA(9), PDGFRB(5), PLCB1(18), PLCB2(2), PLCB4(21), PRKACA(1), PRKACB(1), PRKCA(5), PRKCG(4), PRKG1(7), PRKG2(4), RAF1(3), SOS1(3), SOS2(5), SRC(1), TJP1(2), TUBA1A(1), TUBA3C(7), TUBA3D(3), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB1(2), TUBB2A(1), TUBB4(2), TUBB6(4), TUBB8(5) 6001527 288 30 282 167 189 29 12 39 18 1 0.240 1.000 1.000 259 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(5), BDKRB1(1), BDKRB2(3), C1QC(3), C1R(2), C1S(3), C2(2), C3(14), C4BPA(4), C4BPB(1), C5(2), C5AR1(2), C6(18), C7(19), C8A(13), C8B(11), C9(5), CD55(1), CFB(7), CFH(22), CFI(2), CR1(13), CR2(10), F10(2), F11(2), F13A1(3), F13B(6), F2(3), F2R(2), F5(9), F7(2), F8(12), F9(3), FGA(11), FGG(2), KLKB1(7), KNG1(4), MASP1(2), MASP2(3), MBL2(1), PLAT(1), PLG(11), PROC(1), PROS1(4), SERPINA1(1), SERPINA5(4), SERPINC1(1), SERPINE1(2), SERPINF2(1), TFPI(4), VWF(16) 4114872 283 30 277 110 205 24 7 23 24 0 0.00315 1.000 1.000 260 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT2(1), AKT3(2), CASP8(1), CD40(1), CD86(8), CHUK(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(1), IFNA21(2), IFNA4(1), IFNA5(1), IFNA8(1), IFNAR1(1), IFNB1(1), IKBKE(1), IL12B(1), IL1B(1), IRAK4(1), IRF3(1), IRF5(2), IRF7(2), LBP(1), MAP2K3(2), MAP2K7(2), MAP3K7(1), MAPK1(2), MAPK10(5), MAPK13(1), MAPK14(3), MAPK3(1), MAPK9(1), MYD88(2), NFKB1(4), NFKBIA(1), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), RAC1(5), RELA(1), SPP1(2), STAT1(3), TBK1(2), TICAM1(4), TLR1(4), TLR2(4), TLR3(3), TLR4(8), TLR5(5), TLR7(4), TLR8(3), TLR9(3), TRAF3(3), TRAF6(2) 4082080 133 30 130 70 97 11 6 11 8 0 0.230 1.000 1.000 261 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 BRAF(9), CD244(2), CD48(1), CHP(1), FAS(1), FASLG(2), FCGR3A(2), FYN(1), HLA-A(2), HLA-B(2), HLA-G(1), HRAS(2), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(1), IFNA21(2), IFNA4(1), IFNA5(1), IFNA8(1), IFNAR1(1), IFNB1(1), IFNGR1(2), IFNGR2(1), ITGAL(8), ITGB2(6), KIR2DL1(6), KIR2DL3(2), KIR2DL4(1), KIR3DL1(3), KIR3DL2(1), KLRC3(3), KLRD1(1), KLRK1(2), KRAS(1), LCK(3), LCP2(3), MAPK1(2), MAPK3(1), MICA(2), NCR1(1), NCR2(3), NCR3(1), NFAT5(2), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), NRAS(9), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PLCG1(1), PLCG2(11), PPP3R2(1), PRF1(2), PRKCA(5), PRKCG(4), PTK2B(2), PTPN11(5), RAC1(5), RAC2(1), RAF1(3), SH2D1A(1), SH2D1B(1), SH3BP2(1), SHC1(1), SHC2(3), SHC3(1), SHC4(2), SOS1(3), SOS2(5), SYK(4), TNFRSF10A(2), TNFRSF10C(1), TNFRSF10D(4), TNFSF10(1), ULBP3(2), VAV1(2), VAV3(4), ZAP70(2) 5151182 212 30 202 101 140 20 11 24 17 0 0.121 1.000 1.000 262 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT2(1), AKT3(2), BCL10(1), CARD11(9), CBL(2), CBLB(5), CBLC(1), CD28(1), CD3D(2), CD4(1), CD40LG(1), CD8B(1), CDC42(1), CDK4(2), CHP(1), CHUK(1), CTLA4(1), FYN(1), GRAP2(1), HRAS(2), ICOS(1), IL10(2), IL2(1), IL4(1), ITK(8), KRAS(1), LCK(3), LCP2(3), MALT1(3), MAP3K14(2), NCK2(1), NFAT5(2), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), NFKB1(4), NFKBIA(1), NFKBIB(1), NRAS(9), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PAK7(15), PDK1(1), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PLCG1(1), PPP3R2(1), PRKCQ(5), PTPRC(4), RASGRP1(2), SOS1(3), SOS2(5), TEC(2), VAV1(2), VAV3(4), ZAP70(2) 4631894 167 30 162 84 114 13 7 20 13 0 0.345 1.000 1.000 263 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(1), ACTN2(6), ACTN3(3), ARHGAP5(3), BCAR1(2), CDC42(1), CDH5(4), CLDN1(1), CLDN10(1), CLDN11(3), CLDN14(1), CLDN16(1), CLDN17(1), CLDN18(3), CLDN2(2), CLDN20(1), CLDN4(3), CLDN6(1), CLDN7(1), CTNNA1(2), CTNNA2(8), CTNNA3(13), CTNNB1(3), CTNND1(4), CXCL12(1), CXCR4(1), CYBB(5), GNAI2(4), GRLF1(5), ITGA4(13), ITGAL(8), ITGAM(9), ITGB1(2), ITGB2(6), ITK(8), JAM2(3), MAPK13(1), MAPK14(3), MLLT4(2), MMP2(3), MMP9(4), MSN(1), MYL2(2), MYL5(1), MYL7(1), MYLPF(1), NCF2(2), NCF4(2), NOX1(3), NOX3(1), OCLN(1), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PLCG1(1), PLCG2(11), PRKCA(5), PRKCG(4), PTK2(2), PTK2B(2), PTPN11(5), RAC1(5), RAC2(1), RAP1A(1), RAP1B(1), RAPGEF3(1), RAPGEF4(3), RASSF5(2), ROCK1(2), ROCK2(4), SIPA1(3), THY1(1), TXK(5), VASP(2), VAV1(2), VAV3(4), VCAM1(4), VCL(2) 5633866 252 30 243 102 179 22 9 19 22 1 0.000133 1.000 1.000 264 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(6), ADCY8(17), ATF4(2), BRAF(9), CACNA1C(8), CALM1(1), CALML3(3), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CAMK4(3), CHP(1), CREBBP(4), EP300(7), GNAQ(1), GRIA1(13), GRIA2(5), GRIN1(3), GRIN2A(30), GRIN2B(11), GRIN2C(2), GRIN2D(2), GRM1(7), GRM5(4), HRAS(2), ITPR1(8), ITPR2(4), ITPR3(1), KRAS(1), MAPK1(2), MAPK3(1), NRAS(9), PLCB1(18), PLCB2(2), PLCB4(21), PPP1CB(3), PPP1CC(1), PPP1R12A(2), PPP1R1A(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKCA(5), PRKCG(4), RAF1(3), RAP1A(1), RAP1B(1), RAPGEF3(1), RPS6KA1(3), RPS6KA6(3) 4489874 245 30 234 142 178 17 8 27 14 1 0.300 1.000 1.000 265 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(9), C7orf16(1), CACNA1A(7), CRH(1), CRHR1(2), GNA11(1), GNA12(1), GNAI2(4), GNAQ(1), GNAS(4), GNAZ(3), GRIA1(13), GRIA2(5), GRIA3(10), GRID2(16), GRM1(7), GRM5(4), GUCY1A2(6), GUCY1A3(10), GUCY1B3(1), GUCY2C(10), GUCY2D(4), GUCY2F(7), HRAS(2), IGF1R(1), ITPR1(8), ITPR2(4), ITPR3(1), KRAS(1), LYN(2), MAPK1(2), MAPK3(1), NOS1(20), NOS3(2), NPR1(1), NPR2(2), NRAS(9), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), PLCB1(18), PLCB2(2), PLCB4(21), PPP2CB(1), PPP2R1B(2), PPP2R2A(2), PPP2R2B(1), PPP2R2C(2), PRKCA(5), PRKCG(4), PRKG1(7), PRKG2(4), RAF1(3), RYR1(18) 4994613 290 30 280 151 201 24 11 35 18 1 0.0433 1.000 1.000 266 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ACTN1(1), ACTN2(6), ACTN3(3), APC(5), APC2(3), ARHGEF1(1), ARHGEF12(4), ARPC5(1), BAIAP2(2), BCAR1(2), BDKRB1(1), BDKRB2(3), BRAF(9), CDC42(1), CHRM1(2), CHRM2(8), CHRM3(4), CHRM4(2), CHRM5(2), CRK(1), CYFIP2(8), DIAPH1(5), DIAPH2(1), DIAPH3(4), DOCK1(5), EGF(4), EGFR(6), F2(3), F2R(2), FGD1(2), FGD3(3), FGF12(3), FGF13(2), FGF14(2), FGF16(2), FGF21(2), FGF23(2), FGF3(3), FGF4(1), FGF5(2), FGF6(2), FGF8(1), FGF9(2), FGFR1(4), FGFR2(7), FGFR3(2), FN1(5), GNA12(1), GRLF1(5), GSN(2), HRAS(2), IQGAP1(4), IQGAP2(3), IQGAP3(2), ITGA1(11), ITGA10(2), ITGA11(3), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(13), ITGA5(8), ITGA7(3), ITGA8(7), ITGA9(3), ITGAD(6), ITGAE(6), ITGAL(8), ITGAM(9), ITGAV(3), ITGAX(5), ITGB1(2), ITGB2(6), ITGB3(2), ITGB4(4), ITGB5(2), ITGB6(2), ITGB7(2), ITGB8(8), KRAS(1), LIMK1(1), LIMK2(1), MAPK1(2), MAPK3(1), MSN(1), MYH10(6), MYH14(5), MYH9(1), MYL2(2), MYL5(1), MYL7(1), MYLK(11), MYLK2(2), MYLPF(1), NCKAP1(1), NCKAP1L(5), NRAS(9), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PAK7(15), PDGFRA(9), PDGFRB(5), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PIP4K2A(1), PIP4K2B(1), PIP5K1A(2), PIP5K1B(4), PIP5K1C(1), PPP1CB(3), PPP1CC(1), PPP1R12A(2), PPP1R12B(3), PTK2(2), RAC1(5), RAC2(1), RAF1(3), ROCK1(2), ROCK2(4), SCIN(4), SLC9A1(1), SOS1(3), SOS2(5), SSH1(3), SSH2(4), TIAM1(3), TIAM2(6), VAV1(2), VAV3(4), VCL(2), WAS(2), WASL(4) 12561082 469 30 455 238 322 32 15 57 42 1 0.0419 1.000 1.000 267 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(6), ACACB(5), AKT2(1), AKT3(2), BRAF(9), CALM1(1), CALML3(3), CBL(2), CBLB(5), CBLC(1), CRK(1), ELK1(1), EXOC7(2), FASN(5), FBP1(1), FLOT1(1), FOXO1(3), G6PC(4), GCK(2), GSK3B(1), GYS1(1), GYS2(5), HRAS(2), INPP5D(13), INSR(3), IRS2(1), IRS4(3), KRAS(1), LIPE(1), MAPK1(2), MAPK10(5), MAPK3(1), MAPK9(1), MKNK1(1), NRAS(9), PCK1(8), PDE3A(7), PDE3B(1), PDPK1(2), PFKL(2), PHKA1(8), PHKA2(2), PHKB(1), PHKG2(1), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PKLR(4), PKM2(1), PPARGC1A(3), PPP1CB(3), PPP1CC(1), PPP1R3A(23), PPP1R3B(1), PPP1R3C(1), PPP1R3D(1), PRKAA1(1), PRKAA2(4), PRKAB1(1), PRKACA(1), PRKACB(1), PRKAG1(1), PRKAG2(4), PRKAG3(5), PRKAR2B(3), PRKCI(2), PRKCZ(1), PTPN1(1), PTPRF(11), PYGL(3), PYGM(5), RAF1(3), RAPGEF1(3), RPS6KB1(1), RPS6KB2(1), SHC1(1), SHC2(3), SHC3(1), SHC4(2), SLC2A4(4), SOCS4(2), SORBS1(2), SOS1(3), SOS2(5), SREBF1(3), TRIP10(2), TSC1(1), TSC2(3) 7295154 276 30 268 130 189 21 13 30 23 0 0.0536 1.000 1.000 268 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(6), ADCY2(1), ADCY3(1), ADCY4(1), ADCY5(5), ADCY6(1), ADCY7(2), ADCY8(17), ADCY9(1), ATF4(2), CACNA1C(8), CACNA1D(8), CACNA1F(7), CACNA1S(13), CALM1(1), CALML3(3), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CDC42(1), EGFR(6), ELK1(1), GNA11(1), GNAQ(1), GNAS(4), HRAS(2), ITPR1(8), ITPR2(4), ITPR3(1), KRAS(1), MAP2K3(2), MAP2K7(2), MAP3K2(1), MAP3K3(1), MAP3K4(4), MAPK1(2), MAPK10(5), MAPK13(1), MAPK14(3), MAPK3(1), MAPK7(2), MAPK9(1), MMP14(2), MMP2(3), NRAS(9), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), PLCB1(18), PLCB2(2), PLCB4(21), PLD1(3), PLD2(2), PRKACA(1), PRKACB(1), PRKCA(5), PRKCD(2), PTK2B(2), RAF1(3), SOS1(3), SOS2(5), SRC(1) 5757164 238 30 233 155 162 23 12 25 15 1 0.621 1.000 1.000 269 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(6), ADCY2(1), ADCY3(1), ADCY4(1), ADCY5(5), ADCY6(1), ADCY7(2), ADCY8(17), ADCY9(1), ASIP(1), CALM1(1), CALML3(3), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CREB3(1), CREB3L1(3), CREB3L2(2), CREB3L3(6), CREB3L4(2), CREBBP(4), CTNNB1(3), DCT(1), DVL3(1), EDN1(2), EP300(7), FZD1(1), FZD10(1), FZD2(2), FZD4(1), FZD6(1), FZD7(3), GNAI2(4), GNAQ(1), GNAS(4), GSK3B(1), HRAS(2), KIT(3), KITLG(1), KRAS(1), LEF1(1), MAPK1(2), MAPK3(1), MITF(2), NRAS(9), PLCB1(18), PLCB2(2), PLCB4(21), POMC(1), PRKACA(1), PRKACB(1), PRKCA(5), PRKCG(4), RAF1(3), TCF7L1(1), TYR(3), TYRP1(4), WNT10A(3), WNT10B(1), WNT11(1), WNT2(2), WNT3(1), WNT3A(2), WNT4(2), WNT5A(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(3), WNT9B(2) 4929488 208 30 203 110 140 20 7 25 15 1 0.0840 1.000 1.000 270 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(2), AGTR2(1), ATP8A1(7), AVPR1A(3), AVPR1B(3), BDKRB1(1), BDKRB2(3), BRS3(1), CCKAR(4), CCKBR(2), CCR1(3), CCR10(1), CCR2(6), CCR3(3), CCR4(2), CCR5(4), CCR6(1), CCR8(1), CX3CR1(3), CXCR3(1), CXCR4(1), CXCR6(1), EDNRA(3), FPR1(4), FSHR(3), GALR3(1), GALT(1), GHSR(1), GNB2L1(1), GPR77(3), GRPR(1), LHCGR(9), MC2R(4), MC3R(2), MC5R(1), NMBR(1), NPY1R(6), NPY2R(3), NPY5R(2), NTSR1(2), OPRK1(10), OPRL1(2), OXTR(2), PPYR1(5), SSTR1(2), SSTR2(2), SSTR3(2), SSTR4(1), TACR1(1), TACR2(2), TACR3(6), TRHR(3), TSHR(1) 2386121 141 30 139 111 104 10 4 13 10 0 0.293 1.000 1.000 271 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 AKT2(1), AKT3(2), ARHGAP1(1), ARHGAP4(1), ARHGEF11(7), BTK(4), CDC42(1), INPPL1(7), ITPR1(8), ITPR2(4), ITPR3(1), LIMK1(1), MYLK(11), MYLK2(2), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PAK7(15), PDK1(1), PIK3CA(3), PIK3CD(2), PIK3CG(7), PPP1R13B(2), PTEN(1), RACGAP1(1), ROCK1(2), ROCK2(4), SAG(3), WASL(4) 3194553 105 30 102 52 76 7 5 8 9 0 0.166 1.000 1.000 272 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(6), ADCY2(1), ADCY3(1), ADCY4(1), ADCY5(5), ADCY6(1), ADCY7(2), ADCY8(17), ADCY9(1), ARRB2(3), ATF2(1), ATF4(2), ATF5(2), ATP2A2(4), ATP2A3(4), CACNB3(1), CALM1(1), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CNN1(4), CNN2(1), CORIN(8), CREB3(1), CRH(1), CRHR1(2), DGKZ(1), ETS2(2), GABPB2(3), GJA1(4), GNAQ(1), GNB3(2), GNB4(3), GNB5(1), GNG2(1), GRK4(2), GRK5(2), GUCY1A3(10), IGFBP1(1), IGFBP2(1), IGFBP3(1), IL1B(1), ITPR1(8), ITPR2(4), ITPR3(1), MIB1(3), MYL2(2), MYL4(1), MYLK2(2), NFKB1(4), NOS1(20), NOS3(2), OXTR(2), PDE4B(2), PDE4D(1), PKIG(1), PLCD1(1), PLCG1(1), PLCG2(11), PRKACA(1), PRKACB(1), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(2), PRKCH(2), PRKCQ(5), PRKCZ(1), PRKD1(1), RGS11(1), RGS18(3), RGS3(3), RGS4(1), RGS6(7), RGS7(8), RGS9(3), RLN1(1), RYR1(18), RYR2(22), RYR3(22), SFN(1), SLC8A1(12), SP1(2), TNXB(31), USP5(2), YWHAQ(2) 7942468 340 30 336 216 246 33 10 27 24 0 0.388 1.000 1.000 273 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTN2(6), ACTN3(3), DES(1), DMD(11), MYBPC1(6), MYBPC2(6), MYBPC3(3), MYH3(7), MYH6(13), MYH7(10), MYH8(18), MYL1(4), MYL2(2), MYL3(1), MYL4(1), MYOM1(12), NEB(32), TNNC2(1), TNNI2(1), TNNT1(1), TNNT3(1), TPM1(1), TTN(324), VIM(2) 6039418 467 30 458 191 349 32 17 44 22 3 0.000504 1.000 1.000 274 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(1), ATM(2), BUB1(1), BUB1B(4), CCNA1(2), CCNB3(9), CCND2(1), CCNE1(1), CCNE2(3), CDAN1(1), CDC20(1), CDC25A(3), CDC25B(1), CDC25C(1), CDK4(2), CDKN1A(1), CDKN2A(6), DTX4(1), E2F1(2), E2F2(1), E2F4(1), EP300(7), ESPL1(2), GSK3B(1), HDAC3(3), HDAC4(2), HDAC5(4), HDAC6(1), MAD1L1(2), MCM2(4), MCM3(6), MCM5(1), MCM6(2), MPL(3), ORC1L(4), ORC5L(1), PRKDC(6), PTPRA(2), PTTG2(2), RB1(2), RBL1(2), TBC1D8(3), TFDP1(1), TP53(11), WEE1(2) 5000894 119 29 116 48 70 8 8 18 14 1 0.0813 1.000 1.000 275 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1R(2), C1S(3), C2(2), C3(14), C5(2), C6(18), C7(19), C8A(13), C8B(11), C9(5), MASP1(2) 937967 91 29 86 34 73 4 0 7 7 0 0.0233 1.000 1.000 276 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP5(1), ACPP(2), ALPI(2), ALPL(6), ALPP(2), ALPPL2(6), CYP19A1(1), CYP1A1(2), CYP1A2(2), CYP2A13(5), CYP2A6(3), CYP2A7(2), CYP2B6(5), CYP2C18(10), CYP2C19(7), CYP2C8(11), CYP2C9(12), CYP2E1(5), CYP2F1(3), CYP2J2(2), CYP3A4(3), CYP3A5(2), CYP3A7(7), CYP4B1(7), CYP4F8(5), PON1(4) 1327558 117 29 112 65 90 7 5 4 11 0 0.0671 1.000 1.000 277 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(4), ALG6(1), CCKBR(2), CCR2(6), CCR3(3), CCR5(4), CELSR1(6), CELSR2(5), CELSR3(11), CHRM2(8), CHRM3(4), CXCR3(1), DRD4(1), EDNRA(3), EMR2(2), EMR3(2), F2R(2), FSHR(3), GPR116(9), GPR132(3), GPR133(7), GPR17(1), GPR18(1), GPR55(1), GPR56(1), GPR61(3), GPR77(3), GPR84(2), GRM1(7), GRPR(1), HRH4(1), LGR6(3), LPHN2(13), LPHN3(8), NTSR1(2), OR2M4(3), OR8G2(4), PTGFR(6), SMO(3), SSTR2(2), TSHR(1) 3037621 153 29 151 107 106 11 4 20 11 1 0.531 1.000 1.000 278 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(4), AKR1D1(6), ARSD(1), ARSE(3), CARM1(2), CYP11B1(5), CYP11B2(3), CYP19A1(1), HSD11B1(1), HSD11B2(1), HSD17B2(2), HSD17B7(1), HSD3B1(4), METTL2B(2), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(3), SRD5A1(1), SRD5A2(2), STS(1), SULT1E1(6), SULT2A1(4), UGT1A1(1), UGT1A10(7), UGT1A3(3), UGT1A4(3), UGT1A5(4), UGT1A6(2), UGT1A7(5), UGT1A8(2), UGT1A9(5), UGT2A1(9), UGT2A3(5), UGT2B10(9), UGT2B11(7), UGT2B15(3), UGT2B28(8), UGT2B4(9), UGT2B7(5) 2266792 146 29 143 60 101 18 2 11 13 1 0.00977 1.000 1.000 279 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH5(1), ADH6(2), ADH7(1), ADHFE1(2), AGK(1), AGPAT2(1), AGPAT3(2), AGPAT4(3), AKR1A1(1), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), CEL(2), DAK(1), DGKB(6), DGKD(2), DGKE(1), DGKG(2), DGKH(6), DGKI(6), DGKZ(1), GK(3), GK2(14), GLB1(2), LCT(13), LIPA(1), LIPC(4), LIPF(3), LIPG(2), LPL(1), MGLL(1), PNLIP(2), PNLIPRP1(1), PNLIPRP2(1), PPAP2B(4), PPAP2C(2) 2682525 133 29 129 62 86 15 4 15 13 0 0.106 1.000 1.000 280 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(3), ALOX12(2), ALOX12B(5), ALOX15(4), ALOX15B(2), ALOX5(4), CYP2B6(5), CYP2C18(10), CYP2C19(7), CYP2C8(11), CYP2C9(12), CYP2E1(5), CYP2J2(2), CYP4A11(5), CYP4A22(5), CYP4F2(2), CYP4F3(4), GGT1(1), GPX3(1), GPX5(1), GPX6(6), LTA4H(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), PTGDS(1), PTGIS(4), PTGS1(5), PTGS2(3), TBXAS1(6) 1766914 135 29 133 65 114 7 1 5 8 0 0.00594 1.000 1.000 281 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(1), ABL2(5), AKT2(1), AKT3(2), AREG(1), BRAF(9), BTC(1), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CBL(2), CBLB(5), CBLC(1), CDKN1A(1), CDKN1B(1), CRK(1), EGF(4), EGFR(6), ELK1(1), ERBB2(4), ERBB3(1), ERBB4(13), EREG(3), GAB1(1), GSK3B(1), HRAS(2), KRAS(1), MAP2K7(2), MAPK1(2), MAPK10(5), MAPK3(1), MAPK9(1), MYC(2), NCK2(1), NRAS(9), NRG1(2), NRG2(1), NRG3(6), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PAK7(15), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PLCG1(1), PLCG2(11), PRKCA(5), PRKCG(4), PTK2(2), RAF1(3), RPS6KB1(1), RPS6KB2(1), SHC1(1), SHC2(3), SHC3(1), SHC4(2), SOS1(3), SOS2(5), SRC(1), STAT5A(1), STAT5B(1) 4686152 193 29 183 87 135 17 9 21 11 0 0.0709 1.000 1.000 282 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 110 ABL1(1), ANAPC1(2), ANAPC2(3), ANAPC4(2), ANAPC5(2), ATM(2), ATR(8), BUB1(1), BUB1B(4), CCNA1(2), CCNB3(9), CCND1(1), CCND2(1), CCNE1(1), CCNE2(3), CDC20(1), CDC23(1), CDC25A(3), CDC25B(1), CDC25C(1), CDC27(5), CDK4(2), CDK6(1), CDKN1A(1), CDKN1B(1), CDKN2A(6), CDKN2C(1), CREBBP(4), CUL1(2), E2F1(2), E2F2(1), EP300(7), ESPL1(2), FZR1(2), GSK3B(1), MAD1L1(2), MCM2(4), MCM3(6), MCM5(1), MCM6(2), ORC1L(4), ORC5L(1), PRKDC(6), PTTG2(2), RB1(2), RBL1(2), RBL2(1), SFN(1), SMAD2(1), SMAD3(1), SMC1B(1), TFDP1(1), TP53(11), WEE1(2), YWHAE(1), YWHAG(1), YWHAQ(2) 6219711 142 29 139 50 83 8 12 18 20 1 0.0208 1.000 1.000 283 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP4(1), BMP5(9), BMP6(1), BMP8A(1), BTRC(3), CSNK1A1L(1), CSNK1E(1), CSNK1G1(2), CSNK1G2(1), CSNK1G3(1), DHH(1), FBXW11(2), GLI1(1), GLI2(9), GLI3(3), GSK3B(1), HHIP(5), IHH(2), LRP2(30), PRKACA(1), PRKACB(1), PTCH1(2), PTCH2(6), SHH(1), SMO(3), STK36(3), SUFU(1), WNT10A(3), WNT10B(1), WNT11(1), WNT2(2), WNT3(1), WNT3A(2), WNT4(2), WNT5A(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(3), WNT9B(2) 2756120 119 29 119 60 76 16 7 10 10 0 0.212 1.000 1.000 284 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1B(1), ACVR2A(1), ACVR2B(1), ACVRL1(3), BMP2(1), BMP4(1), BMP5(9), BMP6(1), BMP8A(1), BMPR1B(2), BMPR2(1), CHRD(7), COMP(1), CREBBP(4), CUL1(2), DCN(6), E2F4(1), EP300(7), FST(3), GDF5(3), INHBA(2), INHBB(2), INHBC(2), LEFTY1(1), LEFTY2(1), LTBP1(10), MAPK1(2), MAPK3(1), MYC(2), NODAL(1), NOG(1), PPP2CB(1), PPP2R1B(2), PPP2R2A(2), PPP2R2B(1), PPP2R2C(2), RBL1(2), RBL2(1), ROCK1(2), ROCK2(4), RPS6KB1(1), RPS6KB2(1), SMAD1(2), SMAD2(1), SMAD3(1), SMAD6(3), SMAD7(1), SMAD9(4), SMURF2(5), SP1(2), TFDP1(1), TGFBR2(2), THBS1(10), THBS2(2), THBS3(3), THBS4(4), ZFYVE9(3) 4527278 144 29 143 61 100 15 8 10 11 0 0.0931 1.000 1.000 285 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTB(2), ACTG1(1), ACTN1(1), ACTN2(6), ACTN3(3), ACVR1B(1), BAIAP2(2), CDC42(1), CREBBP(4), CSNK2A1(1), CTNNA1(2), CTNNA2(8), CTNNA3(13), CTNNB1(3), CTNND1(4), EGFR(6), EP300(7), ERBB2(4), FARP2(1), FGFR1(4), FYN(1), IGF1R(1), INSR(3), IQGAP1(4), LEF1(1), LMO7(10), MAP3K7(1), MAPK1(2), MAPK3(1), MET(7), MLLT4(2), NLK(2), PARD3(6), PTPN1(1), PTPRB(16), PTPRF(11), PTPRJ(4), PTPRM(1), PVRL1(3), PVRL2(2), PVRL3(4), PVRL4(3), RAC1(5), RAC2(1), SMAD2(1), SMAD3(1), SNAI1(1), SNAI2(1), SORBS1(2), SRC(1), SSX2IP(2), TCF7L1(1), TGFBR2(2), TJP1(2), VCL(2), WAS(2), WASF3(7), WASL(4) 5479113 195 29 191 105 130 15 6 20 23 1 0.625 1.000 1.000 286 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 CANX(1), CD4(1), CD74(3), CD8B(1), CIITA(4), CTSS(3), HLA-A(2), HLA-B(2), HLA-DMA(1), HLA-DMB(3), HLA-DOA(1), HLA-DQA1(3), HLA-DQA2(4), HLA-DQB1(3), HLA-DRA(3), HLA-DRB1(2), HLA-DRB5(1), HLA-F(1), HLA-G(1), HSPA5(1), IFI30(2), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(1), IFNA21(2), IFNA4(1), IFNA5(1), IFNA8(1), KIR2DL1(6), KIR2DL3(2), KIR2DL4(1), KIR2DS4(3), KIR3DL1(3), KIR3DL2(1), KIR3DL3(3), KLRC3(3), KLRC4(2), KLRD1(1), LGMN(2), LTA(1), NFYB(1), PSME2(1), RFX5(3), TAP2(4), TAPBP(1) 2103804 90 29 88 44 66 13 3 4 4 0 0.101 1.000 1.000 287 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT3(2), BCAR1(2), CAPN1(1), CAPN10(2), CAPN11(2), CAPN2(1), CAPN3(2), CAPN5(2), CAPN6(3), CAPN9(3), CAV1(1), CDC42(1), CRK(1), DOCK1(5), FYN(1), GIT2(1), ITGA10(2), ITGA11(3), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(13), ITGA5(8), ITGA7(3), ITGA8(7), ITGA9(3), ITGAD(6), ITGAE(6), ITGAL(8), ITGAM(9), ITGAV(3), ITGAX(5), ITGB1(2), ITGB2(6), ITGB3(2), ITGB4(4), ITGB5(2), ITGB6(2), ITGB7(2), ITGB8(8), MAP2K3(2), MAPK10(5), MAPK4(5), MAPK6(1), MAPK7(2), MYLK2(2), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PDPK1(2), PTK2(2), RAC1(5), RAC2(1), RAP1B(1), RAPGEF1(3), ROCK1(2), ROCK2(4), SDCCAG8(1), SHC1(1), SHC3(1), SORBS1(2), SOS1(3), SRC(1), TLN1(5), TNS1(2), VASP(2), VAV3(4), VCL(2), ZYX(2) 6076928 210 29 206 97 151 18 6 21 14 0 0.0392 1.000 1.000 288 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(1), BRAF(9), CHUK(1), DAXX(5), ELK1(1), HRAS(2), MAP2K3(2), MAP2K5(1), MAP2K7(2), MAP3K10(2), MAP3K11(3), MAP3K12(1), MAP3K13(2), MAP3K14(2), MAP3K2(1), MAP3K3(1), MAP3K4(4), MAP3K5(7), MAP3K6(1), MAP3K7(1), MAP3K9(8), MAP4K1(4), MAP4K3(1), MAP4K4(4), MAPK1(2), MAPK10(5), MAPK13(1), MAPK14(3), MAPK3(1), MAPK4(5), MAPK6(1), MAPK7(2), MAPK9(1), MAPKAPK2(2), MAPKAPK3(1), MEF2A(2), MEF2C(1), MEF2D(1), MKNK1(1), MYC(2), NFKB1(4), NFKBIA(1), PAK2(2), RAC1(5), RAF1(3), RELA(1), RPS6KA1(3), RPS6KA5(1), RPS6KB1(1), RPS6KB2(1), SHC1(1), SP1(2), STAT1(3) 4322592 125 29 118 48 82 16 5 16 6 0 0.0351 1.000 1.000 289 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(2), BMPR1B(2), CCND2(1), CDK4(2), CDKN1B(1), DMC1(1), ESR2(2), FSHR(3), GJA4(2), INHA(2), LHCGR(9), MLH1(1), MSH5(4), NCOR1(4), NR5A1(2), NRIP1(2), PGR(6), PRLR(9), PTGER2(1), ZP2(2) 1587524 58 29 56 42 43 4 2 6 3 0 0.955 1.000 1.000 290 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1B(1), ACVRL1(3), BMPR2(1), BUB1(1), CDKL1(3), CDKL2(1), CDS1(2), CDS2(1), CLK1(1), CLK2(1), COL4A3BP(1), CSNK2A1(1), DGKB(6), DGKD(2), DGKE(1), DGKG(2), DGKH(6), DGKZ(1), INPP1(1), INPP4B(1), INPP5A(2), INPPL1(7), ITPKB(2), MAP3K10(2), NEK1(1), OCRL(2), PAK4(2), PIK3C2A(1), PIK3C2B(2), PIK3C2G(13), PIK3CA(3), PIK3CB(2), PIK3CG(7), PIM2(2), PLCB1(18), PLCB2(2), PLCB4(21), PLCD1(1), PLCG1(1), PLCG2(11), PRKACA(1), PRKACB(1), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(2), PRKCG(4), PRKCH(2), PRKCQ(5), PRKCZ(1), PRKD1(1), PRKG1(7), RAF1(3), RPS6KA1(3), RPS6KB1(1), STK11(1) 5132850 181 29 178 108 132 15 6 12 15 1 0.696 1.000 1.000 291 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(6), ADCY2(1), ADCY3(1), ADCY4(1), ADCY5(5), ADCY6(1), ADCY7(2), ADCY8(17), ADK(1), AK2(2), AK5(1), ALLC(2), AMPD1(7), AMPD3(2), ATIC(2), ATP5B(1), ATP5C1(1), ATP5F1(2), ATP5G2(1), ATP5H(1), CANT1(4), DGUOK(2), ENPP1(4), ENPP3(7), ENTPD1(2), ENTPD2(1), GART(2), GDA(4), GMPS(1), GUCY1A2(6), GUCY1A3(10), GUCY1B3(1), GUCY2C(10), GUCY2D(4), GUCY2F(7), NPR1(1), NPR2(2), NT5E(1), NT5M(1), PAICS(1), PAPSS2(2), PDE1A(10), PDE4A(2), PDE4B(2), PDE4C(2), PDE4D(1), PDE5A(3), PDE6B(2), PDE6C(10), PDE7B(4), PDE9A(3), PFAS(2), PKLR(4), PKM2(1), POLD1(1), POLD2(1), POLE(6), POLL(4), POLQ(9), POLR1B(4), POLR2A(1), POLR2B(6), POLR2E(1), POLRMT(1), PRPS1L1(4), PRPS2(1), PRUNE(1), RRM1(1) 5833899 218 29 213 109 147 16 8 30 17 0 0.0749 1.000 1.000 292 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT2(1), AKT3(2), CDC42(1), CDKN1B(1), CDKN2A(6), CREB3(1), CREB5(2), ERBB4(13), F2RL2(3), GAB1(1), GSK3B(1), IGFBP1(1), INPPL1(7), IRS2(1), IRS4(3), MET(7), MYC(2), NOLC1(1), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PAK7(15), PARD3(6), PARD6A(1), PDK1(1), PIK3CA(3), PIK3CD(2), PPP1R13B(2), PREX1(2), PTEN(1), PTK2(2), PTPN1(1), RPS6KA1(3), RPS6KB1(1), SFN(1), SHC1(1), SLC2A4(4), SOS1(3), SOS2(5), TSC1(1), TSC2(3), YWHAE(1), YWHAG(1), YWHAQ(2) 3528587 125 29 121 55 88 11 4 8 14 0 0.0630 1.000 1.000 293 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(2), BAX(2), BTK(4), CAD(5), CASP10(1), CASP8(1), CASP8AP2(1), DAXX(5), EGFR(6), EPHB2(8), HSPB1(2), IL1A(3), MAP2K7(2), MAP3K5(7), MAPK1(2), MAPK10(5), MAPK8IP2(3), MAPK8IP3(3), MAPK9(1), MET(7), NFAT5(2), NFKB1(4), NFKBIA(1), NFKBIB(1), NFKBIL2(1), NR0B2(1), PTPN13(3), ROCK1(2), TP53(11), TPX2(1), TUFM(2) 3309702 99 29 96 53 58 9 6 10 16 0 0.503 1.000 1.000 294 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ABP1(5), ACMSD(5), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), AOC3(4), AOX1(5), ASMT(3), CAT(1), CYP19A1(1), CYP1A1(2), CYP1A2(2), CYP2A13(5), CYP2A6(3), CYP2A7(2), CYP2B6(5), CYP2C18(10), CYP2C19(7), CYP2C8(11), CYP2C9(12), CYP2E1(5), CYP2F1(3), CYP2J2(2), CYP3A4(3), CYP3A5(2), CYP3A7(7), CYP4B1(7), CYP4F8(5), DDC(5), EHHADH(1), GCDH(1), HAAO(2), HADHA(1), KMO(5), KYNU(2), MAOB(6), SDS(1), TDO2(1), TPH1(1), WARS(3), WARS2(1) 2505016 160 29 157 87 110 15 9 13 13 0 0.147 1.000 1.000 295 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(5), AXIN1(4), CCND1(1), CCND2(1), CSNK1E(1), CTNNB1(3), DVL3(1), FBXW2(1), FZD1(1), FZD10(1), FZD2(2), FZD6(1), FZD7(3), GSK3B(1), LDLR(2), MAPK10(5), MAPK9(1), MYC(2), PAFAH1B1(1), PPP2R5C(1), PRKCA(5), PRKCD(2), PRKCE(2), PRKCG(4), PRKCH(2), PRKCI(2), PRKCQ(5), PRKCZ(1), PRKD1(1), RAC1(5), SFRP4(1), WNT10A(3), WNT10B(1), WNT11(1), WNT2(2), WNT3(1), WNT4(2), WNT5A(2), WNT7A(3), WNT7B(1) 2728569 84 29 81 44 55 9 4 7 9 0 0.306 1.000 1.000 296 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(1), BAX(2), BCL2L11(3), BIRC3(1), BIRC5(1), CASP1(1), CASP10(1), CASP2(1), CASP7(2), CASP8(1), CASP9(2), CHUK(1), DFFB(1), FAS(1), FASLG(2), HELLS(1), IRF2(1), IRF3(1), IRF5(2), IRF6(3), IRF7(2), LTA(1), MAPK10(5), MYC(2), NFKB1(4), NFKBIA(1), NFKBIB(1), PLEKHG5(4), PRF1(2), RELA(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(3), TNFSF10(1), TP53(11), TP73(2), TRAF1(2), TRAF3(3) 2608871 77 28 76 35 55 7 2 3 10 0 0.225 1.000 1.000 297 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(2), CABIN1(4), CALM1(1), CAMK2B(1), CAMK4(3), CD69(1), CDKN1A(1), CNR1(1), CREBBP(4), CSNK2A1(1), CTLA4(1), EGR3(1), EP300(7), FCER1A(2), FCGR3A(2), GATA4(1), GRLF1(5), GSK3B(1), HRAS(2), ICOS(1), IFNA1(1), IFNB1(1), IL10(2), IL1B(1), IL2(1), IL4(1), ITK(8), MAP2K7(2), MAPK14(3), MAPK9(1), MEF2A(2), MEF2D(1), MYF5(3), NCK2(1), NFAT5(2), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), NFKBIB(1), NPPB(1), NUP214(4), PIN1(1), PPIA(1), PTPRC(4), RELA(1), SFN(1), SLA(1), SP1(2), TRPV6(10), VAV1(2), VAV3(4), XPO5(3) 4156982 122 28 121 70 84 9 5 10 14 0 0.605 1.000 1.000 298 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1R(2), C1S(3), C2(2), C3(14), C5(2), C6(18), C7(19), C8A(13), C9(5), MASP1(2), MASP2(3), MBL2(1) 962581 84 28 79 33 67 4 0 6 7 0 0.0437 1.000 1.000 299 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH6(2), ADH7(1), ADHFE1(2), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH3B1(1), ALDH3B2(2), ALDOA(1), ALDOB(4), BPGM(1), DLAT(1), DLD(1), ENO1(2), FBP1(1), G6PC(4), GAPDH(1), GCK(2), HK2(5), HK3(3), LDHC(3), PDHA2(6), PGK1(1), PGM1(1), PGM3(1), PKLR(4), PKM2(1) 2228301 92 28 90 32 63 10 3 10 6 0 0.00224 1.000 1.000 300 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH6(2), ADH7(1), ADHFE1(2), AGPAT2(1), AGPAT3(2), AGPAT4(3), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), CEL(2), DGKB(6), DGKD(2), DGKE(1), DGKG(2), DGKH(6), DGKZ(1), GK(3), GLB1(2), LCT(13), LIPC(4), LIPF(3), LIPG(2), LPL(1), PNLIP(2), PNLIPRP1(1), PNLIPRP2(1), PPAP2B(4), PPAP2C(2) 2201410 110 28 106 57 74 13 3 11 9 0 0.278 1.000 1.000 301 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH6(2), ADH7(1), ADHFE1(2), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH3B1(1), ALDH3B2(2), ALDOA(1), ALDOB(4), BPGM(1), DLAT(1), DLD(1), ENO1(2), FBP1(1), G6PC(4), GAPDH(1), GCK(2), HK2(5), HK3(3), LDHC(3), PDHA2(6), PGK1(1), PGM1(1), PGM3(1), PKLR(4), PKM2(1) 2228301 92 28 90 32 63 10 3 10 6 0 0.00224 1.000 1.000 302 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(4), DLAT(1), DLD(1), ENO1(2), FBP1(1), G6PC(4), GAPDH(1), GAPDHS(1), GCK(2), GOT2(1), HK2(5), HK3(3), LDHAL6B(1), LDHC(3), MDH2(2), PC(1), PCK1(8), PDHA2(6), PDHX(1), PFKL(2), PGAM2(1), PGK1(1), PGK2(4), PKLR(4), PKM2(1) 1941219 62 28 61 26 49 5 4 3 1 0 0.0161 1.000 1.000 303 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(2), ACAA2(1), ACADL(3), ACADM(1), ACADS(2), ACADSB(1), ACADVL(1), ACOX1(1), ACOX3(2), ACSL1(1), ACSL3(2), ACSL4(2), ACSL5(9), ACSL6(4), ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH5(1), ADH6(2), ADH7(1), ADHFE1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), CPT1A(1), CPT1B(3), CPT1C(1), CYP4A11(5), CYP4A22(5), DCI(1), EHHADH(1), GCDH(1), HADHA(1), HADHB(2), HSD17B4(1) 2244859 98 28 97 46 67 8 4 9 10 0 0.203 1.000 1.000 304 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 IMPA2(1), INPP1(1), INPP4B(1), INPP5A(2), INPP5B(2), INPPL1(7), ITPK1(2), ITPKB(2), MIOX(1), OCRL(2), PI4KA(4), PI4KB(2), PIK3C3(1), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIP4K2A(1), PIP4K2B(1), PIP5K1A(2), PIP5K1B(4), PIP5K1C(1), PLCB1(18), PLCB2(2), PLCB4(21), PLCD1(1), PLCE1(15), PLCG1(1), PLCG2(11), PLCZ1(7), PTEN(1), SYNJ1(9), SYNJ2(6) 3374324 143 28 141 64 111 9 5 6 11 1 0.0185 1.000 1.000 305 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(1), AKT2(1), AKT3(2), APAF1(1), ATM(2), BAX(2), BIRC3(1), CAPN1(1), CAPN2(1), CASP10(1), CASP7(2), CASP8(1), CASP9(2), CFLAR(1), CHP(1), CHUK(1), CSF2RB(3), DFFB(1), FAS(1), FASLG(2), IL1A(3), IL1B(1), IL1R1(3), IL1RAP(2), IRAK2(4), IRAK3(1), IRAK4(1), MAP3K14(2), MYD88(2), NFKB1(4), NFKBIA(1), NTRK1(2), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PPP3R2(1), PRKACA(1), PRKACB(1), PRKAR2B(3), RELA(1), TNFRSF10A(2), TNFRSF10C(1), TNFRSF10D(4), TNFRSF1A(1), TNFSF10(1), TP53(11) 3796144 98 28 97 72 62 9 5 11 11 0 0.975 1.000 1.000 306 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(6), CD19(1), CD1A(4), CD1B(2), CD1C(7), CD1D(1), CD1E(7), CD2(11), CD22(7), CD33(6), CD34(1), CD36(2), CD37(1), CD3D(2), CD4(1), CD44(1), CD5(2), CD55(1), CD8B(1), CR1(13), CR2(10), CSF1(3), CSF1R(3), CSF2RA(6), CSF3(2), CSF3R(1), DNTT(4), EPO(2), EPOR(1), FCER2(1), FCGR1A(1), FLT3(7), GP5(1), GP9(1), GYPA(3), HLA-DRA(3), HLA-DRB1(2), HLA-DRB5(1), IL11RA(1), IL1A(3), IL1B(1), IL1R1(3), IL1R2(1), IL4(1), IL4R(3), IL5RA(7), IL7(2), IL7R(6), IL9R(1), ITGA1(11), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(13), ITGA5(8), ITGAM(9), ITGB3(2), KIT(3), KITLG(1), MME(6), MS4A1(3), TFRC(1), THPO(2), TPO(11) 3707943 232 28 228 96 165 13 8 17 29 0 0.00650 1.000 1.000 307 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT2(1), AKT3(2), BCL10(1), BLNK(4), BTK(4), CARD11(9), CD19(1), CD22(7), CD72(1), CHP(1), CHUK(1), CR2(10), FCGR2B(1), GSK3B(1), HRAS(2), INPP5D(13), KRAS(1), LILRB3(2), LYN(2), MALT1(3), NFAT5(2), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), NFKB1(4), NFKBIA(1), NFKBIB(1), NRAS(9), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PLCG2(11), PPP3R2(1), RAC1(5), RAC2(1), RASGRP3(3), SYK(4), VAV1(2), VAV3(4) 3402149 146 28 140 59 93 11 9 16 17 0 0.0214 1.000 1.000 308 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(1), ARRB2(3), CALM1(1), CALML3(3), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CLCA2(3), CLCA4(8), CNGA3(9), CNGA4(5), CNGB1(6), GUCA1A(1), GUCA1C(2), PDC(1), PDE1C(13), PRKACA(1), PRKACB(1), PRKG1(7), PRKG2(4) 1379332 75 28 74 41 50 6 2 11 6 0 0.359 1.000 1.000 309 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(3), ADCY4(1), ADCY6(1), ADCY8(17), CACNA1A(7), CACNA1B(6), GNAS(4), GNAT3(1), GNB3(2), GRM4(8), ITPR3(1), KCNB1(10), PDE1A(10), PLCB2(2), PRKACA(1), PRKACB(1), SCNN1A(3), SCNN1B(3), SCNN1G(9), TAS1R1(1), TAS1R2(7), TAS2R1(2), TAS2R10(2), TAS2R16(2), TAS2R38(3), TAS2R39(1), TAS2R4(1), TAS2R40(1), TAS2R41(6), TAS2R5(1), TAS2R60(6), TAS2R8(1), TAS2R9(2), TRPM5(2) 2587015 128 28 123 118 89 12 4 14 9 0 0.935 1.000 1.000 310 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(5), ACSL1(1), ACSL3(2), ACSL4(2), ACSL5(9), ACSL6(4), ADIPOQ(1), ADIPOR1(2), ADIPOR2(1), AKT2(1), AKT3(2), CAMKK2(3), CD36(2), CHUK(1), CPT1A(1), CPT1B(3), CPT1C(1), G6PC(4), IRS2(1), IRS4(3), JAK1(1), JAK2(1), LEP(1), LEPR(6), MAPK10(5), MAPK9(1), NFKB1(4), NFKBIA(1), NFKBIB(1), NPY(1), PCK1(8), POMC(1), PPARA(1), PPARGC1A(3), PRKAA1(1), PRKAA2(4), PRKAB1(1), PRKAG1(1), PRKAG2(4), PRKAG3(5), PRKCQ(5), PTPN11(5), RELA(1), RXRA(2), RXRB(2), RXRG(2), SLC2A1(1), SLC2A4(4), STAT3(1), STK11(1), TNFRSF1A(1), TNFRSF1B(2), TYK2(3) 3790974 130 28 128 70 88 11 5 10 16 0 0.367 1.000 1.000 311 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(1), ACTB(2), ACTG1(1), ARHGEF2(5), ARPC5(1), CDC42(1), CLDN1(1), CTNNB1(3), FYN(1), HCLS1(3), ITGB1(2), KRT18(1), NCK2(1), OCLN(1), PRKCA(5), ROCK1(2), ROCK2(4), TLR4(8), TLR5(5), TUBA1A(1), TUBA3C(7), TUBA3D(3), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB1(2), TUBB2A(1), TUBB4(2), TUBB6(4), TUBB8(5), WAS(2), WASL(4), YWHAQ(2) 2392462 86 28 86 32 57 10 2 9 8 0 0.0120 1.000 1.000 312 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(1), ACTB(2), ACTG1(1), ARHGEF2(5), ARPC5(1), CDC42(1), CLDN1(1), CTNNB1(3), FYN(1), HCLS1(3), ITGB1(2), KRT18(1), NCK2(1), OCLN(1), PRKCA(5), ROCK1(2), ROCK2(4), TLR4(8), TLR5(5), TUBA1A(1), TUBA3C(7), TUBA3D(3), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB1(2), TUBB2A(1), TUBB4(2), TUBB6(4), TUBB8(5), WAS(2), WASL(4), YWHAQ(2) 2392462 86 28 86 32 57 10 2 9 8 0 0.0120 1.000 1.000 313 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(12), COL4A2(8), COL4A3(11), COL4A4(23), COL4A5(13), COL4A6(14), F10(2), F11(2), F2(3), F2R(2), F5(9), F8(12), F9(3), FGA(11), FGG(2), KLKB1(7), PROC(1), PROS1(4), SERPINC1(1) 2021574 140 28 136 36 109 9 6 14 2 0 0.0424 1.000 1.000 314 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(2), ADRA1B(2), ADRA1D(1), ADRA2A(1), ADRB1(3), CHRM1(2), CHRM2(8), CHRM3(4), CHRM4(2), CHRM5(2), DRD1(1), DRD2(2), DRD3(3), DRD4(1), DRD5(6), HRH1(4), HTR1A(2), HTR1D(3), HTR1E(1), HTR1F(5), HTR2A(2), HTR2B(2), HTR2C(3), HTR4(5), HTR5A(5), HTR6(1), HTR7(3) 1148026 76 28 76 47 48 9 3 9 7 0 0.0691 1.000 1.000 315 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 BDKRB2(3), CALM1(1), CAV1(1), CHRM1(2), CHRNA1(3), FLT1(6), FLT4(8), KDR(8), NOS3(2), PDE2A(1), PDE3A(7), PDE3B(1), PRKACB(1), PRKAR2B(3), PRKG1(7), PRKG2(4), RYR2(22), SYT1(4) 1866785 84 28 84 72 54 8 1 8 13 0 0.986 1.000 1.000 316 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT2(1), AKT3(2), BCR(5), BLNK(4), BTK(4), CD19(1), CD22(7), CR2(10), DAG1(2), FLOT1(1), GSK3B(1), INPP5D(13), ITPR1(8), ITPR2(4), ITPR3(1), LYN(2), MAP4K1(4), MAPK1(2), MAPK3(1), NFATC1(5), NFATC2(1), NR0B2(1), PDK1(1), PIK3CA(3), PIK3CD(2), PLCG2(11), PPP1R13B(2), PTPRC(4), RAF1(3), SHC1(1), SOS1(3), SOS2(5), SYK(4), VAV1(2) 3377098 121 28 121 59 80 12 9 9 11 0 0.146 1.000 1.000 317 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT2(1), AKT3(2), BRD4(5), CAP1(1), CBL(2), CDC42(1), CDKN2A(6), F2RL2(3), FLOT1(1), GSK3B(1), IGFBP1(1), INPPL1(7), IRS2(1), IRS4(3), LNPEP(1), MAPK1(2), MAPK3(1), PARD3(6), PARD6A(1), PDK1(1), PIK3CA(3), PIK3CD(2), PPYR1(5), PTEN(1), PTPN1(1), RAF1(3), RPS6KA1(3), RPS6KB1(1), SERPINB6(2), SFN(1), SHC1(1), SLC2A4(4), SORBS1(2), SOS1(3), SOS2(5), YWHAE(1), YWHAG(1), YWHAQ(2) 2723238 88 28 86 40 56 10 4 7 11 0 0.242 1.000 1.000 318 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(1), ACTG2(1), CDC42(1), FLNA(5), FLNC(20), FSCN1(1), FSCN2(2), FSCN3(3), LIMK1(1), MYH2(22), MYLK(11), MYLK2(2), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PAK7(15), ROCK1(2), ROCK2(4), VASP(2), WASL(4) 2182820 106 28 102 59 77 12 2 5 10 0 0.181 1.000 1.000 319 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT2(1), AKT3(2), BRAF(9), DAG1(2), DRD2(2), EGFR(6), EPHB2(8), ITPKB(2), ITPR1(8), ITPR2(4), ITPR3(1), KCNJ3(8), KCNJ5(3), MAPK1(2), PI3(1), PIK3CB(2), PLCB1(18), PLCB2(2), PLCB4(21), RAF1(3), SHC1(1), SOS1(3), SOS2(5), SRC(1), STAT3(1) 2671588 116 28 111 66 84 12 8 5 6 1 0.314 1.000 1.000 320 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(6), CARM1(2), CTCFL(5), DOT1L(4), EED(1), EHMT1(2), EZH2(2), FBXO11(2), HCFC1(4), JMJD4(2), KDM6A(1), MEN1(1), MLL(10), MLL2(12), MLL3(18), MLL4(3), NSD1(5), OGT(2), PPP1CB(3), PPP1CC(1), PRDM2(3), PRDM7(2), PRDM9(17), PRMT1(1), PRMT5(2), PRMT7(2), PRMT8(3), RBBP5(1), SATB1(4), SETD1A(8), SETD2(3), SETD7(2), SETDB1(4), SETDB2(2), SUV39H1(1), SUV420H1(1), WHSC1L1(2) 5385168 144 27 143 55 98 15 7 18 6 0 0.120 1.000 1.000 321 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(4), AKR1D1(6), ARSD(1), ARSE(3), CYP11B1(5), CYP11B2(3), HSD11B1(1), HSD11B2(1), HSD17B2(2), HSD3B1(4), SRD5A1(1), SRD5A2(2), STS(1), SULT1E1(6), SULT2A1(4), UGT1A1(1), UGT1A10(7), UGT1A3(3), UGT1A4(3), UGT1A5(4), UGT1A6(2), UGT1A7(5), UGT1A8(2), UGT1A9(5), UGT2B15(3), UGT2B4(9) 1236990 88 27 85 38 58 11 2 7 9 1 0.0426 1.000 1.000 322 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(5), AGMAT(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH4A1(1), AOC3(4), ARG2(1), ASL(1), CKMT2(1), CPS1(8), DAO(4), GAMT(2), GATM(1), GOT2(1), MAOB(6), NOS1(20), NOS3(2), OAT(2), P4HA1(4), P4HA2(1), P4HA3(4), PYCR1(1), RARS(4), SMS(1) 2010765 87 27 87 46 56 12 3 7 9 0 0.250 1.000 1.000 323 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(2), F11(2), F13B(6), F2(3), F5(9), F7(2), F8(12), F9(3), FGA(11), FGG(2), LPA(18), PLAT(1), PLG(11), SERPINB2(3), SERPINE1(2), SERPINF2(1), VWF(16) 1598811 104 27 103 42 77 9 5 5 8 0 0.117 1.000 1.000 324 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 65 ATM(2), CCNA1(2), CCND1(1), CCND2(1), CCNE1(1), CCNE2(3), CDC25A(3), CDK4(2), CDKN1A(1), CDKN1B(1), CDKN2A(6), CDKN2C(1), CREB3(1), CREB3L1(3), CREB3L3(6), CREB3L4(2), E2F1(2), E2F2(1), E2F4(1), MCM2(4), MCM3(6), MCM5(1), MCM6(2), MYC(2), MYT1(4), ORC1L(4), ORC5L(1), POLA2(2), POLE(6), POLE2(1), RB1(2), RBL1(2), TFDP1(1), TNXB(31), TP53(11), WEE1(2) 3603928 122 27 118 38 74 9 4 17 17 1 0.00223 1.000 1.000 325 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(3), AGPS(1), CDS1(2), CDS2(1), CHAT(7), CHKA(1), CHKB(1), CLC(2), CPT1B(3), DGKB(6), DGKD(2), DGKE(1), DGKG(2), DGKH(6), DGKZ(1), ETNK1(1), GPD1(3), LGALS13(2), PAFAH1B1(1), PCYT1A(2), PCYT1B(3), PISD(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), PLCB2(2), PLCG1(1), PLCG2(11), PPAP2B(4), PPAP2C(2) 2280980 91 27 89 38 66 9 2 6 8 0 0.0251 1.000 1.000 326 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(5), ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH5(1), ADH6(2), ADH7(1), ADHFE1(2), ALDH1A3(1), ALDH3A1(2), ALDH3B1(1), ALDH3B2(2), AOC3(4), AOX1(5), CARM1(2), COMT(2), DBH(3), DCT(1), DDC(5), ECH1(1), ESCO2(2), FAH(1), GOT2(1), HGD(1), MAOB(6), METTL2B(2), MYST3(1), MYST4(1), NAT6(1), PNMT(2), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(3), SH3GLB1(1), TAT(2), TH(3), TPO(11), TYR(3), TYRP1(4) 2706256 119 27 118 60 83 14 7 9 6 0 0.232 1.000 1.000 327 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(2), ALPL(6), ALPP(2), ALPPL2(6), ASCC3(6), ATP13A2(4), DDX18(1), DDX4(5), DDX41(2), DDX50(4), DDX51(2), DDX52(2), DDX54(1), DDX55(1), DDX56(1), ENTPD7(1), EP400(5), GGH(1), IFIH1(2), MOV10L1(4), NUDT5(1), QDPR(2), RAD54B(1), RUVBL2(2), SETX(1), SKIV2L2(1), SMARCA2(4) 2850362 70 27 69 27 51 3 4 5 7 0 0.0559 1.000 1.000 328 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(2), ACADL(3), ACADM(1), ACOX1(1), ACOX2(3), ACOX3(2), ACSL1(1), ACSL3(2), ACSL4(2), ACSL5(9), ACSL6(4), ADIPOQ(1), ANGPTL4(3), APOA1(1), APOA5(2), CD36(2), CPT1A(1), CPT1B(3), CPT1C(1), CYP27A1(1), CYP4A11(5), CYP4A22(5), CYP7A1(3), CYP8B1(5), EHHADH(1), FABP1(2), FABP4(1), FADS2(1), GK(3), GK2(14), HMGCS2(7), LPL(1), ME1(4), MMP1(4), OLR1(1), PCK1(8), PDPK1(2), PLTP(1), PPARA(1), PPARD(1), PPARG(2), RXRA(2), RXRB(2), RXRG(2), SCP2(1), SLC27A1(2), SLC27A2(2), SLC27A5(1), SLC27A6(10), SORBS1(2), UBC(2), UCP1(1) 2994300 144 27 141 77 100 9 7 13 15 0 0.270 1.000 1.000 329 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(1), ATM(2), ATR(8), BAI1(6), BAX(2), CASP8(1), CASP9(2), CCNB3(9), CCND1(1), CCND2(1), CCNE1(1), CCNE2(3), CDK4(2), CDK6(1), CDKN1A(1), CDKN2A(6), FAS(1), GTSE1(4), IGFBP3(1), PTEN(1), RFWD2(3), SERPINB5(3), SERPINE1(2), SESN2(2), SESN3(1), SFN(1), STEAP3(2), THBS1(10), TP53(11), TP73(2), TSC2(3) 2957749 94 27 91 30 58 7 7 8 14 0 0.0104 1.000 1.000 330 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT2(1), AKT3(2), CASP9(2), CDC42(1), CHP(1), HRAS(2), KDR(8), KRAS(1), MAPK1(2), MAPK13(1), MAPK14(3), MAPK3(1), MAPKAPK2(2), MAPKAPK3(1), NFAT5(2), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), NOS3(2), NRAS(9), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), PLCG1(1), PLCG2(11), PPP3R2(1), PRKCA(5), PRKCG(4), PTGS2(3), PTK2(2), RAC1(5), RAC2(1), RAF1(3), SH2D2A(1), SHC2(3), SPHK2(3), SRC(1), VEGFA(2) 3297488 135 27 129 59 89 10 6 19 11 0 0.0525 1.000 1.000 331 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(2), ATP6AP1(1), ATP6V0A1(4), ATP6V0A2(1), ATP6V0A4(7), ATP6V0D2(1), ATP6V1B2(2), ATP6V1C2(4), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(2), CDC42(1), CHUK(1), EGFR(6), IGSF5(2), JAM2(3), LYN(2), MAP3K14(2), MAPK10(5), MAPK13(1), MAPK14(3), MAPK9(1), MET(7), NFKB1(4), NFKBIA(1), NOD1(5), PLCG1(1), PLCG2(11), PTPN11(5), PTPRZ1(7), RAC1(5), RELA(1), SRC(1), TJP1(2) 3213650 109 27 105 59 76 8 3 10 12 0 0.410 1.000 1.000 332 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(7), AR(2), ESR1(2), ESR2(2), ESRRA(1), HNF4A(7), NPM1(1), NR1D2(1), NR1H2(1), NR1I2(1), NR1I3(2), NR2C2(2), NR2F1(2), NR2F2(1), NR3C1(3), NR5A1(2), NR5A2(7), PGR(6), PPARA(1), PPARD(1), PPARG(2), RARA(1), RARB(2), RARG(1), ROR1(6), RORA(1), RORC(1), RXRA(2), RXRB(2), RXRG(2), THRB(4) 1899976 76 27 75 41 59 2 1 7 7 0 0.345 1.000 1.000 333 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT2(1), AKT3(2), BCR(5), BTK(4), CD19(1), CDKN2A(6), DAPP1(3), FLOT1(1), GAB1(1), ITPR1(8), ITPR2(4), ITPR3(1), LYN(2), NR0B2(1), PDK1(1), PIK3CA(3), PLCG2(11), PPP1R13B(2), PREX1(2), PTEN(1), PTPRC(4), RPS6KA1(3), RPS6KB1(1), SAG(3), SYK(4), TEC(2), VAV1(2) 2515322 79 27 77 50 55 6 5 4 9 0 0.595 1.000 1.000 334 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT2(1), AKT3(2), BCR(5), BLNK(4), BTK(4), CD19(1), DAG1(2), EPHB2(8), ITPKB(2), LYN(2), MAPK1(2), NFAT5(2), NFKB1(4), NFKBIA(1), NFKBIB(1), NFKBIL2(1), PI3(1), PIK3CA(3), PIK3CD(2), PLCG2(11), PPP1R13B(2), RAF1(3), SERPINA4(5), SHC1(1), SOS1(3), SOS2(5), SYK(4), VAV1(2) 2415720 84 27 83 50 59 13 4 2 6 0 0.510 1.000 1.000 335 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(2), CD28(1), CD3D(2), CTLA4(1), DAG1(2), EPHB2(8), FBXW7(4), GRAP2(1), ITK(8), ITPKB(2), LCK(3), LCP2(3), MAPK1(2), NFAT5(2), NFKB1(4), NFKBIA(1), NFKBIB(1), NFKBIL2(1), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PAK7(15), PLCG1(1), PTPRC(4), RAF1(3), RASGRP1(2), RASGRP2(2), RASGRP3(3), RASGRP4(4), SOS1(3), SOS2(5), VAV1(2), ZAP70(2) 2534594 103 27 100 43 74 8 5 4 12 0 0.0503 1.000 1.000 336 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(5), ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH6(2), ADH7(1), ADHFE1(2), ALDH1A3(1), ALDH3A1(2), ALDH3B1(1), ALDH3B2(2), AOC3(4), AOX1(5), COMT(2), DBH(3), DCT(1), DDC(5), FAH(1), GOT2(1), HGD(1), MAOB(6), PNMT(2), TAT(2), TH(3), TPO(11), TYR(3) 1442252 94 27 93 45 64 11 6 7 6 0 0.0843 1.000 1.000 337 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(1), AGT(2), AGTR1(2), AGTR2(1), CMA1(1), COL4A1(12), COL4A2(8), COL4A3(11), COL4A4(23), COL4A5(13), COL4A6(14), REN(1) 1146701 89 26 86 23 71 5 3 9 1 0 0.337 1.000 1.000 338 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(2), ACAA2(1), ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH6(2), ADH7(1), ADHFE1(2), AKR1C4(4), AKR1D1(6), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), BAAT(4), CEL(2), CYP27A1(1), CYP7A1(3), HADHB(2), SOAT2(1), SRD5A1(1), SRD5A2(2) 1064634 74 26 73 30 43 10 4 8 9 0 0.0627 1.000 1.000 339 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(1), CAMK1G(2), ELK1(1), FPR1(4), GNA15(2), HRAS(2), MAP2K3(2), MAPK1(2), MAPK14(3), MAPK3(1), NCF2(2), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), NFKB1(4), NFKBIA(1), PIK3C2G(13), PLCB1(18), RAC1(5), RAF1(3), RELA(1), SYT1(4) 1736528 85 26 80 32 66 5 2 5 7 0 0.0340 1.000 1.000 340 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 B4GALT1(1), B4GALT2(1), G6PC(4), GALT(1), GCK(2), GLB1(2), HK2(5), HK3(3), LALBA(4), LCT(13), MGAM(47), PGM1(1), PGM3(1) 1486817 85 26 84 40 58 14 2 8 3 0 0.0696 1.000 1.000 341 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(24), GABBR1(3), GPRC5A(1), GPRC5B(3), GPRC5C(2), GRM1(7), GRM2(3), GRM3(18), GRM4(8), GRM5(4), GRM7(9), GRM8(12) 951858 94 26 89 47 66 6 6 8 8 0 0.0126 1.000 1.000 342 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 UGP2(1), UGT1A1(1), UGT1A10(7), UGT1A3(3), UGT1A4(3), UGT1A5(4), UGT1A6(2), UGT1A7(5), UGT1A8(2), UGT1A9(5), UGT2A1(9), UGT2A3(5), UGT2B10(9), UGT2B11(7), UGT2B15(3), UGT2B28(8), UGT2B4(9), UGT2B7(5) 1233289 88 26 87 36 64 10 1 5 7 1 0.0734 1.000 1.000 343 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B10(2), B4GALT1(1), B4GALT2(1), G6PC(4), GALT(1), GANC(1), GCK(2), GLB1(2), HK2(5), HK3(3), LALBA(4), LCT(13), MGAM(47), PFKL(2), PGM1(1), PGM3(1), RDH11(1), RDH12(1), RDH13(1), UGP2(1) 1763593 94 26 93 48 65 14 2 8 5 0 0.120 1.000 1.000 344 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(2), ACAA2(1), ACAD9(1), ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH5(1), ADH6(2), ADH7(1), ADHFE1(2), AKR1B10(2), AKR1C4(4), AKR1D1(6), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), BAAT(4), CEL(2), CYP27A1(1), CYP7A1(3), HADHB(2), LIPA(1), RDH11(1), RDH12(1), RDH13(1), SLC27A5(1), SOAT2(1), SRD5A1(1), SRD5A2(2) 1449444 81 26 80 42 49 10 4 8 10 0 0.265 1.000 1.000 345 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(2), AASS(1), AKR1B10(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), BBOX1(1), DOT1L(4), EHHADH(1), EHMT1(2), GCDH(1), HADHA(1), HSD17B4(1), NSD1(5), OGDH(3), OGDHL(9), PIPOX(2), PLOD1(1), PLOD2(4), PLOD3(2), RDH11(1), RDH12(1), RDH13(1), SETD1A(8), SETD7(2), SETDB1(4), SUV39H1(1) 2644141 70 26 70 32 42 7 3 11 7 0 0.254 1.000 1.000 346 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(2), AANAT(1), ABP1(5), ACMSD(5), AFMID(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), AOC3(4), AOX1(5), ASMT(3), CARM1(2), CAT(1), CYP1A1(2), CYP1A2(2), CYP1B1(1), DDC(5), EHHADH(1), GCDH(1), HAAO(2), HADHA(1), HSD17B4(1), INMT(4), KMO(5), KYNU(2), LNX1(6), MAOB(6), METTL2B(2), NFX1(1), OGDH(3), OGDHL(9), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(3), TDO2(1), TPH1(1), TPH2(8), WARS(3), WARS2(1) 2763736 117 26 116 55 77 11 7 13 9 0 0.104 1.000 1.000 347 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(3), CDS1(2), CDS2(1), CHAT(7), CHKA(1), CHKB(1), DGKB(6), DGKD(2), DGKE(1), DGKG(2), DGKH(6), DGKI(6), DGKZ(1), ESCO2(2), ETNK1(1), GPD1(3), GPD1L(1), MYST3(1), MYST4(1), NAT6(1), PCYT1A(2), PCYT1B(3), PISD(1), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), PLD1(3), PLD2(2), PPAP2B(4), PPAP2C(2), PTDSS2(1), SH3GLB1(1) 2979095 89 26 87 44 58 12 2 7 10 0 0.320 1.000 1.000 348 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(6), ACACB(5), ACOT12(3), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), DLAT(1), DLD(1), HAGH(1), LDHAL6B(1), LDHC(3), LDHD(1), MDH2(2), ME1(4), ME3(2), PC(1), PCK1(8), PDHA2(6), PKLR(4), PKM2(1) 2137938 60 26 60 27 37 6 6 9 2 0 0.187 1.000 1.000 349 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(1), ALAS2(1), BLVRA(1), COX10(1), COX15(2), CP(4), CPOX(2), EPRS(3), FTH1(1), FTMT(2), MMAB(1), PPOX(1), UGT1A1(1), UGT1A10(7), UGT1A3(3), UGT1A4(3), UGT1A5(4), UGT1A6(2), UGT1A7(5), UGT1A8(2), UGT1A9(5), UGT2A1(9), UGT2A3(5), UGT2B10(9), UGT2B11(7), UGT2B15(3), UGT2B28(8), UGT2B4(9), UGT2B7(5) 1913851 107 26 106 39 79 10 3 6 8 1 0.0133 1.000 1.000 350 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), FUCA1(2), GALNS(2), GLB1(2), GNS(1), HEXA(2), HEXB(2), HGSNAT(1), HPSE(2), HPSE2(2), HYAL1(1), IDS(5), IDUA(1), LCT(13), MAN2B1(2), MAN2B2(4), MAN2C1(1), MANBA(3), NAGLU(1), NEU1(2), NEU2(2), NEU3(1), SPAM1(8) 1559857 61 26 61 31 44 5 3 7 2 0 0.339 1.000 1.000 351 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT2(1), AKT3(2), BTK(4), FCER1A(2), FYN(1), GAB2(1), HRAS(2), IL4(1), INPP5D(13), KRAS(1), LCP2(3), LYN(2), MAP2K3(2), MAP2K7(2), MAPK1(2), MAPK10(5), MAPK13(1), MAPK14(3), MAPK3(1), MAPK9(1), MS4A2(5), NRAS(9), PDK1(1), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), PLCG1(1), PLCG2(11), PRKCA(5), PRKCD(2), PRKCE(2), RAC1(5), RAC2(1), RAF1(3), SOS1(3), SOS2(5), SYK(4), VAV1(2), VAV3(4) 3299621 147 26 141 57 98 13 6 18 12 0 0.00868 1.000 1.000 352 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP1(1), INPP4B(1), INPP5A(2), INPPL1(7), ITPKB(2), MIOX(1), OCRL(2), PIK3C2A(1), PIK3C2B(2), PIK3C2G(13), PIK3CA(3), PIK3CB(2), PIK3CG(7), PLCB1(18), PLCB2(2), PLCB4(21), PLCD1(1), PLCG1(1), PLCG2(11) 2036995 98 26 96 41 77 7 3 3 7 1 0.0264 1.000 1.000 353 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 CHUK(1), DAXX(5), EGF(4), EGFR(6), ETS1(2), ETS2(2), HRAS(2), MAP2K3(2), MAP2K7(2), MAP3K14(2), MAP3K5(7), MAPK1(2), MAPK13(1), MAPK14(3), MAPK3(1), NFKB1(4), NFKBIA(1), PRKCA(5), PRKCD(2), PRKCE(2), PRKCG(4), PRKCH(2), PRKCQ(5), RAF1(3), RELA(1), SP1(2), TNFRSF1A(1), TNFRSF1B(2) 2234921 76 26 75 43 51 7 1 12 5 0 0.595 1.000 1.000 354 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CDC40(4), CLK2(1), COL2A1(5), CPSF1(1), CPSF3(1), CSTF1(3), CSTF2(1), CSTF2T(1), CSTF3(3), DDIT3(1), DDX20(1), DHX15(2), DHX16(1), DHX38(3), DHX8(1), DHX9(2), DICER1(5), GIPC1(1), LOC440563(5), METTL3(1), NONO(1), NXF1(1), PAPOLA(3), POLR2A(1), PPM1G(1), PRPF18(2), PRPF3(1), PRPF4B(2), PRPF8(4), PTBP1(1), PTBP2(1), RBM5(3), RNMT(5), SF3A1(1), SF3A2(3), SF3A3(2), SF3B1(6), SF3B2(2), SF3B4(2), SFRS12(2), SFRS14(1), SFRS16(1), SFRS7(1), SFRS8(2), SNRPA(1), SNRPB(2), SNRPB2(1), SNRPE(1), SNRPN(2), SNURF(2), SRPK1(1), SRRM1(1), SUPT5H(2), U2AF2(2) 4855386 107 26 106 50 68 6 7 15 11 0 0.555 1.000 1.000 355 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 AGT(2), CALM1(1), CAMK1G(2), CAMK4(3), CREBBP(4), EDN1(2), ELSPBP1(1), F2(3), FKBP1A(1), GATA4(1), GSK3B(1), HAND1(1), HAND2(1), HRAS(2), LIF(1), MAPK1(2), MAPK14(3), MAPK3(1), MEF2C(1), MYH2(22), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), PIK3CA(3), PRKACB(1), PRKAR2B(3), RAF1(3), RPS6KB1(1), SYT1(4) 2321243 84 26 83 63 58 6 6 6 8 0 0.967 1.000 1.000 356 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), DLG4(3), GRIN1(3), GRIN2A(30), GRIN2B(11), GRIN2C(2), GRIN2D(2), NOS1(20), PRKACB(1), PRKAR2B(3), PRKCA(5), SYT1(4) 1162525 85 26 84 56 60 10 3 5 7 0 0.529 1.000 1.000 357 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(6), ADH5(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), DLAT(1), DLD(1), HAGH(1), LDHC(3), LDHD(1), MDH2(2), ME1(4), ME3(2), PC(1), PCK1(8), PDHA2(6), PKLR(4), PKM2(1) 1689107 54 26 54 22 37 4 4 7 2 0 0.116 1.000 1.000 358 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 APC(5), AR(2), BRAF(9), DAG1(2), EGFR(6), GNA11(1), GNA15(2), GNAQ(1), ITPKB(2), ITPR1(8), ITPR2(4), ITPR3(1), KCNJ3(8), KCNJ5(3), MAPK1(2), MAPK10(5), MAPK14(3), PHKA2(2), PIK3CA(3), PIK3CD(2), RAF1(3), SRC(1) 2429582 75 26 72 46 49 6 8 9 3 0 0.703 1.000 1.000 359 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 BRAF(9), CREB3(1), CREB5(2), CREBBP(4), DAG1(2), EGR3(1), EGR4(1), ELK1(1), FRS2(2), GNAQ(1), MAP1B(7), MAP2K7(2), MAPK1(2), MAPK10(5), MAPK3(1), MAPK8IP2(3), MAPK8IP3(3), MAPK9(1), NTRK1(2), OPN1LW(1), PIK3C2G(13), PIK3CA(3), PIK3CD(2), PTPN11(5), SHC1(1), SRC(1), TH(3) 2333699 79 26 74 36 55 8 2 7 7 0 0.241 1.000 1.000 360 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT2(1), AKT3(2), IARS(5), IL13RA1(2), IL4(1), IL4R(3), INPP5D(13), JAK1(1), JAK2(1), NR0B2(1), PI3(1), PIK3CA(3), PPP1R13B(2), RPS6KB1(1), SERPINA4(5), SHC1(1), SOS1(3), SOS2(5), SRC(1), STAT6(4), TYK2(3) 1683378 59 26 59 26 35 7 3 7 7 0 0.296 1.000 1.000 361 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 ATF2(1), CDC42(1), DLD(1), DUSP10(3), GAB1(1), GCK(2), IL1R1(3), MAP2K5(1), MAP2K7(2), MAP3K10(2), MAP3K11(3), MAP3K12(1), MAP3K13(2), MAP3K2(1), MAP3K3(1), MAP3K4(4), MAP3K5(7), MAP3K7(1), MAP3K9(8), MAPK10(5), MAPK7(2), MAPK9(1), MYEF2(1), NFATC3(2), NR2C2(2), PAPPA(14), SHC1(1), TP53(11), TRAF6(2), ZAK(3) 2298661 89 26 86 28 59 9 2 11 8 0 0.0267 1.000 1.000 362 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT2(1), AKT3(2), APC(5), AXIN1(4), AXIN2(2), CER1(6), CTNNB1(3), DACT1(3), DKK2(4), DKK3(2), DKK4(1), GSK3B(1), LRP1(13), MVP(3), NKD1(1), NKD2(1), PIN1(1), PTPRA(2), SENP2(3), SFRP1(1), TSHB(3), WIF1(4) 1826180 66 26 65 31 38 10 4 8 6 0 0.354 1.000 1.000 363 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(5), ATF2(1), AXIN1(4), BMP10(2), BMP2(1), BMP4(1), BMP5(9), BMPR2(1), CHRD(7), CTNNB1(3), FZD1(1), GATA4(1), GSK3B(1), MAP3K7(1), MEF2C(1), MYL2(2), NOG(1), NPPB(1), TGFBR2(2), TGFBR3(2) 1655691 47 25 47 21 30 5 3 5 4 0 0.407 1.000 1.000 364 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(1), BAX(2), BIRC3(1), CASP2(1), CASP7(2), CASP8(1), CASP9(2), FAS(1), FASLG(2), MAP3K14(2), MAPK10(5), MYC(2), NFKB1(4), NFKBIA(1), PARP1(1), PRF1(2), RELA(1), TNFRSF1A(1), TNFRSF1B(2), TNFSF10(1), TP53(11), TRAF1(2) 1702576 48 25 47 17 31 3 2 5 7 0 0.127 1.000 1.000 365 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(6), ELK1(1), GNAS(4), HRAS(2), IGF1R(1), ITGB1(2), MAPK1(2), MAPK3(1), MKNK1(1), MYC(2), NGFR(5), PDGFRA(9), PTPRR(5), RAF1(3), RPS6KA1(3), RPS6KA5(1), SHC1(1), SOS1(3), SRC(1), STAT3(1) 1501148 54 25 54 31 32 10 1 8 3 0 0.595 1.000 1.000 366 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), CAD(5), CANT1(4), CDA(1), CTPS2(1), DCTD(1), DHODH(1), DPYD(18), DPYS(6), ENTPD1(2), ENTPD4(1), ENTPD6(1), NME6(2), NME7(2), NT5C1A(2), NT5C1B(6), NT5C3(2), NT5E(1), NT5M(1), POLA2(2), POLD1(1), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLR1A(5), POLR1B(4), POLR2A(1), POLR2B(6), POLR2E(1), POLR3A(2), POLR3B(4), POLR3G(1), POLR3GL(1), PRIM2(3), RRM1(1), TXNRD1(3), TXNRD2(2), UPB1(1) 3695932 106 25 105 48 71 7 4 14 10 0 0.139 1.000 1.000 367 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(5), AGXT(1), AGXT2(3), AKR1B10(2), ALAS2(1), AOC3(4), BHMT(1), CBS(2), CHDH(3), CHKA(1), CHKB(1), DAO(4), DLD(1), DMGDH(1), GAMT(2), GARS(2), GATM(1), GCAT(2), GLDC(1), MAOB(6), PHGDH(2), PIPOX(2), PISD(1), PSAT1(1), RDH11(1), RDH12(1), RDH13(1), SARDH(9), SARS(1), SARS2(1), SDS(1), TARS2(2) 1951856 67 25 67 42 47 6 5 4 5 0 0.579 1.000 1.000 368 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ARG2(1), ASL(1), ASS1(1), CKMT2(1), CPS1(8), DAO(4), EPRS(3), GAMT(2), GATM(1), GLUD2(2), GOT2(1), LAP3(1), NOS1(20), NOS3(2), OAT(2), P4HA1(4), P4HA2(1), P4HA3(4), PYCR1(1), RARS(4) 1636347 65 25 65 37 44 7 1 5 8 0 0.462 1.000 1.000 369 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 C1GALT1(1), C1GALT1C1(1), GALNT1(1), GALNT11(1), GALNT12(1), GALNT13(8), GALNT14(8), GALNT2(1), GALNT3(1), GALNT4(2), GALNT5(3), GALNT6(4), GALNT7(2), GALNT8(5), GALNT9(1), GALNTL1(2), GALNTL2(10), GALNTL4(3), GALNTL5(2), GCNT1(2), GCNT4(3), OGT(2), ST3GAL1(2), ST6GALNAC1(1), WBSCR17(11) 1472587 78 25 76 45 59 5 2 6 6 0 0.616 1.000 1.000 370 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(1), ARSE(3), B4GALT6(1), DEGS2(3), ENPP7(1), GAL3ST1(2), GALC(2), GLB1(2), LCT(13), NEU1(2), NEU2(2), NEU3(1), PPAP2B(4), PPAP2C(2), SGMS1(3), SGPP2(1), SMPD2(1), SMPD3(1), SMPD4(2), SPHK2(3), SPTLC1(1), SPTLC2(1), UGCG(1), UGT8(1) 1618726 54 25 53 31 38 4 1 6 5 0 0.512 1.000 1.000 371 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AADAC(1), ABAT(3), ACADS(2), ACSM1(6), AKR1B10(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH5A1(3), ALDH7A1(1), BDH1(1), EHHADH(1), GAD1(4), GAD2(1), HADHA(1), HMGCL(3), HMGCS2(7), HSD17B4(1), ILVBL(2), L2HGDH(2), OXCT1(1), PDHA2(6), PLA1A(3), PRDX6(1), RDH11(1), RDH12(1), RDH13(1) 1859635 64 25 63 43 43 8 1 8 4 0 0.845 1.000 1.000 372 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT2(1), AKT3(2), BRAF(9), CAB39(1), EIF4B(2), MAPK1(2), MAPK3(1), PDPK1(2), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PRKAA1(1), PRKAA2(4), RICTOR(1), RPS6KA1(3), RPS6KA6(3), RPS6KB1(1), RPS6KB2(1), STK11(1), TSC1(1), TSC2(3), ULK1(2), ULK2(2), VEGFA(2), VEGFC(7) 2411513 69 25 63 33 48 6 3 5 7 0 0.291 1.000 1.000 373 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(1), ACTN2(6), ACTN3(3), BCAR1(2), BCR(5), CAPN1(1), CAV1(1), FYN(1), HRAS(2), ITGA1(11), ITGB1(2), MAPK1(2), MAPK3(1), PPP1R12B(3), PTK2(2), RAF1(3), RAP1A(1), ROCK1(2), SHC1(1), SOS1(3), SRC(1), TLN1(5), VCL(2), ZYX(2) 2134252 63 25 62 28 41 9 2 6 4 1 0.114 1.000 1.000 374 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(5), CANT1(4), CDA(1), CTPS2(1), DCTD(1), DHODH(1), DPYD(18), DPYS(6), ENTPD1(2), NT5E(1), NT5M(1), POLD1(1), POLD2(1), POLE(6), POLL(4), POLQ(9), POLR1B(4), POLR2A(1), POLR2B(6), POLR2E(1), POLRMT(1), RRM1(1), TXNRD1(3), UNG(1), UPB1(1) 2620655 81 25 80 27 51 6 2 13 9 0 0.0101 1.000 1.000 375 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(8), CDR1(3), DGKI(6), IL6ST(1), PIGK(1), RPL10(2), RPL15(1), RPL18(1), RPL18A(1), RPL19(1), RPL26(1), RPL35(1), RPL3L(2), RPL4(1), RPL5(1), RPS10(1), RPS15(1), RPS18(1), RPS27(1), RPS6KA1(3), RPS6KA6(3), RPS6KB1(1), RPS6KB2(1), RPS7(1), SLC36A2(2), TBC1D10C(2), UBC(2) 2367132 50 25 48 40 34 5 2 6 3 0 0.970 1.000 1.000 376 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(5), BLNK(4), ELK1(1), HRAS(2), LYN(2), MAPK1(2), MAPK3(1), MAPK8IP3(3), PAPPA(14), RAC1(5), RPS6KA1(3), SHC1(1), SOS1(3), SYK(4), VAV1(2), VAV3(4) 1455783 57 25 53 33 44 7 0 3 3 0 0.522 1.000 1.000 377 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT2(1), AKT3(2), ARHGEF11(7), CDC42(1), DLG4(3), LPA(18), MAP3K5(7), NFKB1(4), NFKBIA(1), NFKBIB(1), NFKBIL2(1), PDK1(1), PHKA2(2), PI3(1), PIK3CB(2), PLD1(3), PLD2(2), PTK2(2), ROCK1(2), ROCK2(4), SERPINA4(5), TBXA2R(2) 2238447 72 25 71 34 46 8 2 9 7 0 0.316 1.000 1.000 378 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(3), APC(5), DAG1(2), DLG4(3), EPHB2(8), GNAQ(1), ITPR1(8), ITPR2(4), ITPR3(1), KCNJ3(8), KCNJ5(3), MAPK1(2), RAC1(5), RYR1(18) 2087022 71 25 67 52 45 11 5 5 5 0 0.815 1.000 1.000 379 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(3), ABP1(5), ACADL(3), ACADM(1), ACADSB(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), AOC3(4), CNDP1(2), DPYD(18), DPYS(6), EHHADH(1), GAD1(4), GAD2(1), HADHA(1), SDS(1), SMS(1), UPB1(1) 1328470 65 24 64 36 47 5 2 7 4 0 0.425 1.000 1.000 380 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(2), AGTR2(1), CALM1(1), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), F2(3), FYN(1), GNA11(1), HRAS(2), JAK2(1), MAPK1(2), MAPK14(3), MAPK3(1), MAPT(3), MYLK(11), PLCG1(1), PRKCA(5), PTK2B(2), RAF1(3), SHC1(1), SOS1(3), STAT1(3), STAT3(1), STAT5A(1), SYT1(4) 1896893 62 24 61 37 44 8 1 6 3 0 0.518 1.000 1.000 381 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(2), CSF1R(3), EGF(4), EGFR(6), MET(7), PDGFRA(9), PRKCA(5), SH3GLB1(1), SH3GLB2(1), SH3KBP1(2), SRC(1) 888298 41 24 41 29 24 4 1 7 5 0 0.916 1.000 1.000 382 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(3), CALCR(6), CALCRL(6), CRHR1(2), CRHR2(1), ELTD1(7), EMR1(8), EMR2(2), GIPR(1), GLP1R(3), GLP2R(7), GPR64(1), LPHN1(1), LPHN2(13), LPHN3(8), SCTR(3), VIPR1(1), VIPR2(3) 1205045 76 24 71 35 61 6 2 4 3 0 0.0266 1.000 1.000 383 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(1), APAF1(1), ARHGDIB(1), BIRC3(1), CASP2(1), CASP7(2), CASP8(1), CASP9(2), CFLAR(1), CHUK(1), DAXX(5), DFFB(1), GSN(2), LMNA(1), MAP2K7(2), MAP3K14(2), MAP3K5(7), NFKB1(4), NFKBIA(1), NUMA1(2), PAK2(2), PRKCD(2), PRKDC(6), PTK2(2), RB1(2), RELA(1), SPTAN1(2), TNFRSF1A(1), TNFRSF1B(2), TRAF1(2) 3154582 61 24 60 30 40 6 1 7 6 1 0.409 1.000 1.000 384 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(8), ATP4A(2), ATP5B(1), ATP5C1(1), ATP5F1(2), ATP5G2(1), ATP5H(1), ATP5O(1), ATP6AP1(1), ATP6V0A1(4), ATP6V0A2(1), ATP6V0A4(7), ATP6V0D2(1), ATP6V1B2(2), ATP6V1C2(4), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(2), COX10(1), COX15(2), COX4I2(1), CYC1(1), NDUFA10(2), NDUFA13(3), NDUFAB1(1), NDUFB3(1), NDUFB5(2), NDUFS2(1), NDUFS4(1), NDUFS5(1), NDUFS6(1), NDUFS7(1), NDUFS8(3), SDHA(1), SDHC(1), SDHD(1), UQCRC1(1), UQCRC2(1), UQCRFS1(1) 2560283 75 24 75 26 49 4 0 11 11 0 0.0271 1.000 1.000 385 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(5), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH3B1(1), ALDH3B2(2), ALDH7A1(1), AOC3(4), ASPA(1), CARM1(2), CNDP1(2), DDC(5), FTCD(1), HAL(3), HDC(5), MAOB(6), METTL2B(2), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(3), PRPS2(1), UROC1(4) 1800600 63 24 62 42 39 8 4 6 6 0 0.704 1.000 1.000 386 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(3), ABP1(5), ACADM(1), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), AOC3(4), CNDP1(2), DPYD(18), DPYS(6), EHHADH(1), GAD1(4), GAD2(1), HADHA(1), HIBCH(1), SMS(1), UPB1(1) 1235792 59 24 58 33 40 5 2 8 4 0 0.454 1.000 1.000 387 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(2), ALOX15(4), ALOX5(4), CYP1A2(2), CYP2C18(10), CYP2C19(7), CYP2C8(11), CYP2C9(12), CYP2E1(5), CYP2J2(2), CYP3A4(3), CYP3A43(4), CYP3A5(2), CYP3A7(7), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), RDH11(1), RDH12(1), RDH13(1) 1091299 95 24 93 49 74 3 3 4 11 0 0.0976 1.000 1.000 388 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), AARS2(1), CARS(3), CARS2(1), DARS(2), EPRS(3), FARS2(2), FARSA(2), FARSB(3), GARS(2), IARS(5), IARS2(4), KARS(2), LARS(1), MARS2(2), NARS(1), RARS(4), SARS(1), SARS2(1), TARS2(2), VARS(5), WARS(3), WARS2(1), YARS(1), YARS2(2) 2495950 55 24 53 33 41 3 2 3 6 0 0.689 1.000 1.000 389 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(3), B3GALNT1(1), B3GALT1(1), B3GNT3(1), B3GNT4(1), B4GALNT1(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), B4GALT6(1), FUT2(1), FUT3(2), FUT5(1), FUT6(1), FUT9(7), PIGC(2), PIGF(1), PIGG(2), PIGK(1), PIGL(1), PIGN(1), PIGO(3), PIGQ(2), PIGS(1), PIGU(1), PIGV(2), PIGX(1), PIGZ(1), ST3GAL1(2), ST3GAL6(1), ST6GALNAC3(2), ST6GALNAC5(2), ST6GALNAC6(1), ST8SIA1(1), ST8SIA5(5), UGCG(1) 2203500 58 24 58 43 35 6 6 6 5 0 0.848 1.000 1.000 390 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 APH1A(1), CREBBP(4), DLL1(1), DLL3(1), DLL4(3), DTX1(5), DTX2(1), DTX3(2), DTX4(1), DVL3(1), EP300(7), JAG1(2), JAG2(1), MAML1(1), MAML2(3), MAML3(3), MFNG(4), NCOR2(9), NCSTN(2), NOTCH1(1), NOTCH2(4), NOTCH3(5), NOTCH4(14), NUMBL(3), RBPJ(2), RBPJL(1) 3146825 82 24 82 45 57 7 1 11 6 0 0.697 1.000 1.000 391 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 CRK(1), DOCK1(5), ELK1(1), GAB1(1), HGF(4), HRAS(2), ITGA1(11), ITGB1(2), MAP4K1(4), MAPK1(2), MAPK3(1), MET(7), PIK3CA(3), PTEN(1), PTK2(2), PTK2B(2), PTPN11(5), RAF1(3), RAP1A(1), RAP1B(1), SOS1(3), SRC(1), STAT3(1) 2003965 64 24 62 30 42 10 0 6 6 0 0.443 1.000 1.000 392 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(1), APOA1(1), CD36(2), CPT1B(3), CREBBP(4), EHHADH(1), EP300(7), FABP1(2), HSD17B4(1), LPL(1), MAPK1(2), MAPK3(1), ME1(4), MYC(2), NCOA1(1), NCOR1(4), NCOR2(9), NFKBIA(1), NR0B2(1), NR2F1(2), NRIP1(2), PIK3CA(3), PPARA(1), PRKACB(1), PRKAR2B(3), PRKCA(5), PTGS2(3), RB1(2), RELA(1), RXRA(2), SP1(2), STAT5A(1), STAT5B(1) 2897794 77 24 77 38 55 5 4 6 6 1 0.416 1.000 1.000 393 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 CDC42(1), CREB3(1), CREB5(2), DUSP10(3), EEF2K(4), ELK1(1), HSPB1(2), IL1R1(3), MAP2K3(2), MAP3K10(2), MAP3K4(4), MAP3K5(7), MAP3K7(1), MAPK1(2), MAPK13(1), MAPK14(3), MAPKAPK2(2), MKNK1(1), MYEF2(1), NFKB1(4), NR2C2(2), TRAF6(2) 1523119 51 24 50 23 29 5 1 10 6 0 0.324 1.000 1.000 394 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(1), EEF2K(4), EIF2AK1(1), EIF2AK2(2), EIF2AK3(2), EIF2B1(2), EIF2B3(1), EIF2B4(1), EIF4A2(2), EIF4G1(7), EIF4G3(6), EIF5B(1), ETF1(1), GSPT2(2), PABPC1(1), PABPC3(2), PAIP1(2), SLC35A4(2) 1992923 40 24 40 17 23 6 3 2 6 0 0.345 1.000 1.000 395 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BAX(2), BCL2A1(1), BCL2L2(2), CASP1(1), CASP10(1), CASP2(1), CASP7(2), CASP8(1), CASP9(2), CD40(1), CD40LG(1), DAXX(5), DFFB(1), FAS(1), FASLG(2), IKBKE(1), LTA(1), NFKB1(4), NFKBIA(1), NGFR(5), NR3C1(3), NTRK1(2), PTPN13(3), SFRS2IP(3), TNFRSF1A(1), TNFRSF1B(2), TRAF1(2), TRAF3(3), TRAF6(2) 1976246 58 23 58 29 39 7 1 7 4 0 0.494 1.000 1.000 396 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(4), BTK(4), CALM1(1), ELK1(1), HRAS(2), LYN(2), MAPK14(3), MAPK3(1), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), PLCG1(1), PRKCA(5), RAC1(5), RAF1(3), SHC1(1), SOS1(3), SYK(4), SYT1(4), VAV1(2) 1745298 60 23 57 26 43 6 3 4 4 0 0.211 1.000 1.000 397 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(4), CARM1(2), CCND1(1), CREBBP(4), EP300(7), ESR1(2), GRIP1(3), GTF2A1(1), GTF2E1(1), GTF2F1(1), HDAC3(3), HDAC4(2), HDAC5(4), HDAC6(1), MEF2C(1), NCOR2(9), NRIP1(2), PELP1(5), POLR2A(1), TBP(2) 2076223 56 23 56 23 44 0 4 4 4 0 0.185 1.000 1.000 398 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(6), ITGAV(3), ITGB3(2), MAPK1(2), MAPK3(1), PDGFRA(9), PIK3CA(3), PLCB1(18), PRKCA(5), PTK2(2), RAC1(5), SMPD2(1), SRC(1) 1257271 58 23 54 29 44 5 0 5 4 0 0.323 1.000 1.000 399 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(5), AGXT(1), AGXT2(3), ALAS2(1), AOC3(4), BHMT(1), CBS(2), CHDH(3), CHKA(1), CHKB(1), CPT1B(3), DAO(4), DLD(1), DMGDH(1), GAMT(2), GARS(2), GATM(1), GCAT(2), GLDC(1), MAOB(6), PISD(1), PLCB2(2), PLCG1(1), PLCG2(11), SARDH(9), SARS(1) 1920397 70 23 70 40 51 6 6 4 3 0 0.343 1.000 1.000 400 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSD(1), ARSE(3), GAL3ST1(2), GALC(2), GLB1(2), LCT(13), NEU1(2), NEU2(2), NEU3(1), PPAP2B(4), PPAP2C(2), SMPD2(1), SPTLC1(1), SPTLC2(1), UGCG(1) 1093725 38 23 37 20 26 4 1 6 1 0 0.492 1.000 1.000 401 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(5), ALDH1A3(1), ALDH3A1(2), ALDH3B1(1), ALDH3B2(2), AOC3(4), DDC(5), EPX(4), ESCO2(2), GOT2(1), LPO(4), MAOB(6), MPO(2), MYST3(1), MYST4(1), NAT6(1), PRDX6(1), SH3GLB1(1), TAT(2), TPO(11) 1563008 57 23 57 36 37 8 4 5 3 0 0.670 1.000 1.000 402 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10(1), ALG10B(1), ALG13(2), ALG2(2), ALG3(1), ALG6(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), DAD1(1), DHDDS(1), DPM1(1), FUT8(2), MAN1A1(3), MAN1B1(1), MAN1C1(3), MGAT1(1), MGAT3(4), MGAT4A(2), MGAT5(1), MGAT5B(3), RFT1(2), RPN2(1), ST6GAL1(1), STT3B(1) 1932400 39 23 39 19 25 4 4 3 3 0 0.315 1.000 1.000 403 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 GALNS(2), GLB1(2), GNS(1), HEXA(2), HEXB(2), HGSNAT(1), HPSE(2), HPSE2(2), HYAL1(1), IDS(5), IDUA(1), LCT(13), NAGLU(1), SPAM1(8) 928936 43 23 43 25 29 4 2 7 1 0 0.634 1.000 1.000 404 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(2), ANAPC2(3), ANAPC4(2), ANAPC5(2), BTRC(3), CDC20(1), CDC23(1), CDC27(5), CUL1(2), CUL2(3), CUL3(1), FBXW11(2), FBXW7(4), FZR1(2), ITCH(2), SMURF2(5), TCEB1(1), TCEB2(1), UBE2D3(1), UBE2E1(1), UBE2E2(1), VHL(2), WWP1(1), WWP2(3) 1820225 51 23 50 19 33 2 2 5 9 0 0.284 1.000 1.000 405 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 CAPN1(1), CAPN2(1), CXCR3(1), EGF(4), EGFR(6), HRAS(2), ITGA1(11), ITGB1(2), MAPK1(2), MAPK3(1), MYL2(2), MYLK(11), PRKACB(1), PRKAR2B(3), PTK2(2), TLN1(5) 1480360 55 23 53 34 42 4 4 4 1 0 0.531 1.000 1.000 406 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(6), ARHGEF1(1), F2(3), F2R(2), F2RL3(1), GNA12(1), GNAQ(1), MAP3K7(1), PIK3CA(3), PLCB1(18), PPP1R12B(3), PRKCA(5), PTK2B(2), ROCK1(2) 1181634 49 23 48 26 38 5 2 3 1 0 0.429 1.000 1.000 407 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 UCHL1(2), UCHL3(1), UGT1A1(1), UGT1A10(7), UGT1A3(3), UGT1A4(3), UGT1A5(4), UGT1A6(2), UGT1A7(5), UGT1A8(2), UGT1A9(5), UGT2B15(3), UGT2B4(9) 805257 47 23 45 25 34 6 1 2 3 1 0.344 1.000 1.000 408 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(1), BLVRA(1), CP(4), CPOX(2), EPRS(3), PPOX(1), UGT1A1(1), UGT1A10(7), UGT1A3(3), UGT1A4(3), UGT1A5(4), UGT1A6(2), UGT1A7(5), UGT1A8(2), UGT1A9(5), UGT2B15(3), UGT2B4(9) 1257319 56 23 55 27 41 6 2 3 3 1 0.264 1.000 1.000 409 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP1(1), ARHGAP4(1), ARHGAP5(3), ARHGAP6(4), ARHGEF1(1), ARHGEF11(7), ARHGEF5(4), BAIAP2(2), DIAPH1(5), GSN(2), LIMK1(1), MYL2(2), MYLK(11), OPHN1(1), PIP5K1A(2), PIP5K1B(4), PPP1R12B(3), ROCK1(2), SRC(1), TLN1(5), VCL(2) 2052564 64 23 62 31 51 3 3 5 2 0 0.168 1.000 1.000 410 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K7(2), MAPK1(2), MAPK10(5), MAPK13(1), MAPK14(3), MAPK3(1), MAPK8IP2(3), MAPK8IP3(3), MAPK9(1), NFKB1(4), NFKBIA(1), NFKBIB(1), NFKBIL2(1), PIK3CA(3), PIK3CD(2), SYT1(4), TRAF3(3), TRAF5(2), TRAF6(2) 1532256 44 23 44 19 32 3 2 4 3 0 0.144 1.000 1.000 411 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 DAG1(2), ETFA(2), GCA(1), ITGA9(3), ITPKB(2), ITPR1(8), ITPR2(4), ITPR3(1), MAPK1(2), MAPK3(1), NR1I3(2), PDE3A(7), PDE3B(1), PI3(1), PIK3C2G(13), PIK3CA(3), PIK3CD(2), RIPK3(2), VASP(2) 2216989 59 23 58 28 41 4 3 5 6 0 0.226 1.000 1.000 412 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(4), DLG4(3), EPHB2(8), F2(3), F2RL1(2), F2RL2(3), F2RL3(1), MAP2K5(1), MAPK1(2), MAPK7(2), MYEF2(1), PLD1(3), PLD2(2), PTK2(2), RAF1(3), RASAL1(4), SRC(1), TEC(2), VAV1(2) 1250730 49 23 48 34 32 6 2 4 5 0 0.774 1.000 1.000 413 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(3), CSF1R(3), DDX20(1), E2F1(2), E2F4(1), ETS1(2), ETS2(2), ETV3(4), HDAC5(4), HRAS(2), NCOR2(9), RBL1(2), RBL2(1), SIN3A(2), SIN3B(3) 1188773 41 22 41 20 30 3 1 5 2 0 0.277 1.000 1.000 414 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(4), CALM1(1), ELK1(1), FCER1A(2), HRAS(2), LYN(2), MAP2K7(2), MAPK1(2), MAPK3(1), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), PAK2(2), PIK3CA(3), PLA2G4A(1), PLCG1(1), RAF1(3), SHC1(1), SOS1(3), SYK(4), SYT1(4), VAV1(2) 1961835 55 22 55 32 37 6 3 4 5 0 0.732 1.000 1.000 415 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 APC(5), AXIN1(4), CCND1(1), CTNNB1(3), FZD1(1), GJA1(4), GSK3B(1), LBP(1), LEF1(1), MYD88(2), NFKB1(4), PDPK1(2), PIK3CA(3), RELA(1), TLR4(8) 1388726 41 22 39 27 25 5 4 4 3 0 0.875 1.000 1.000 416 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(5), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH3B1(1), ALDH3B2(2), AOC3(4), ASPA(1), CNDP1(2), DDC(5), HAL(3), HDC(5), MAOB(6), PRPS2(1) 1108359 47 22 46 31 27 6 4 5 5 0 0.640 1.000 1.000 417 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), EXT2(1), EXTL3(3), HS2ST1(1), HS3ST1(4), HS3ST2(1), HS3ST3A1(2), HS3ST5(3), HS6ST1(1), HS6ST2(1), HS6ST3(2), NDST1(1), NDST2(1), NDST3(7), NDST4(12) 925340 41 22 41 29 27 4 1 6 3 0 0.839 1.000 1.000 418 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD9(1), ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH5(1), ADH6(2), ADH7(1), ADHFE1(2), DHRS1(2), DHRS2(1), DHRSX(2), ESCO2(2), MYST3(1), MYST4(1), NAT6(1), SH3GLB1(1) 1140400 46 22 45 25 33 4 2 5 2 0 0.702 1.000 1.000 419 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(4), ABCC2(3), ABCG2(4), BCHE(1), CES1(1), CES2(1), CYP3A4(3), CYP3A5(2), UGT1A1(1), UGT1A10(7), UGT1A3(3), UGT1A4(3), UGT1A5(4), UGT1A6(2), UGT1A7(5), UGT1A8(2), UGT1A9(5) 1044595 51 22 50 28 31 7 2 6 5 0 0.374 1.000 1.000 420 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(5), ALDH1A3(1), ALDH3A1(2), ALDH3B1(1), ALDH3B2(2), AOC3(4), DDC(5), EPX(4), GOT2(1), LPO(4), MAOB(6), MPO(2), PRDX2(1), PRDX6(1), TAT(2), TPO(11) 1001028 52 22 52 29 33 7 4 5 3 0 0.256 1.000 1.000 421 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(2), ESR2(2), PDE1A(10), PDE1B(1), PLCB1(18), PLCB2(2), VIP(1) 502907 36 22 32 20 34 0 0 1 1 0 0.336 1.000 1.000 422 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), DAG1(2), ITPKB(2), ITPR1(8), ITPR2(4), ITPR3(1), NFAT5(2), PDE6A(4), PDE6B(2), PDE6C(10), SLC6A13(4), TF(2) 1630647 47 22 47 28 35 1 2 5 4 0 0.447 1.000 1.000 423 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 EGFR(6), IGF1R(1), MYC(2), POLR2A(1), PRKCA(5), RB1(2), TEP1(15), TERF1(1), TERT(1), TNKS(2), TP53(11) 1284148 47 22 46 24 28 4 3 4 7 1 0.424 1.000 1.000 424 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CHUK(1), ELK1(1), MAP2K3(2), MAP3K14(2), MAP3K7(1), MAPK14(3), MYD88(2), NFKB1(4), NFKBIA(1), PPARA(1), RELA(1), TLR10(3), TLR2(4), TLR3(3), TLR4(8), TLR7(4), TLR9(3), TRAF6(2) 1653641 46 22 46 24 31 3 3 4 5 0 0.489 1.000 1.000 425 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(2), AGTR1(2), ATF2(1), CALM1(1), EGFR(6), ELK1(1), GNAQ(1), HRAS(2), MAPK1(2), MAPK3(1), MEF2A(2), MEF2C(1), MEF2D(1), PRKCA(5), PTK2(2), PTK2B(2), RAC1(5), RAF1(3), SHC1(1), SOS1(3), SRC(1), SYT1(4) 1525636 49 21 46 23 35 8 1 3 2 0 0.312 1.000 1.000 426 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(1), CHAT(7), COMT(2), DBH(3), DDC(5), GAD1(4), GAD2(1), HDC(5), PAH(2), PNMT(2), SLC18A3(1), TH(3), TPH1(1) 649721 38 21 37 25 30 4 2 0 2 0 0.446 1.000 1.000 427 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(4), BTG1(1), CLOCK(1), CRY1(1), CRY2(2), ETV6(1), GFRA1(4), GSTM3(2), HERPUD1(1), HSPA8(1), KLF9(1), MYF6(5), NCKAP1(1), NCOA4(1), NR1D2(1), PER1(3), PIGF(1), PPP1R3C(1), PPP2CB(1), PSMA4(1), PURA(1), SF3A3(2), TOB1(2), UCP3(1), UGP2(1), VAPA(1), ZFR(4) 1665283 46 21 46 15 22 5 5 8 6 0 0.219 1.000 1.000 428 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(2), AKT2(1), AKT3(2), DAG1(2), GNAQ(1), ITPKB(2), ITPR1(8), ITPR2(4), ITPR3(1), NFKB1(4), NFKBIA(1), NFKBIB(1), NFKBIL2(1), PDK1(1), PHKA2(2), PIK3CB(2), PLD1(3), PLD2(2) 2046775 40 21 40 29 25 4 4 3 4 0 0.787 1.000 1.000 429 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(5), CREB3(1), CREB5(2), DAG1(2), EPHB2(8), GNAQ(1), ITPKB(2), MAP2K7(2), MAPK1(2), MAPK10(5), MAPK8IP2(3), MAPK8IP3(3), MAPK9(1) 1303484 37 21 36 23 25 3 1 3 5 0 0.737 1.000 1.000 430 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(1), CD3D(2), ELK1(1), FYN(1), HRAS(2), LCK(3), MAPK3(1), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), NFKB1(4), NFKBIA(1), PIK3CA(3), PLCG1(1), PRKCA(5), RAC1(5), RAF1(3), RELA(1), SHC1(1), SOS1(3), SYT1(4), VAV1(2), ZAP70(2) 2179278 60 21 57 29 43 8 2 3 4 0 0.378 1.000 1.000 431 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF2B1(2), EIF2B3(1), EIF2B4(1), FLT1(6), FLT4(8), HRAS(2), KDR(8), NOS3(2), PIK3CA(3), PLCG1(1), PRKCA(5), PTK2(2), SHC1(1), VHL(2) 1559029 44 21 44 28 28 6 0 5 5 0 0.809 1.000 1.000 432 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(2), ATR(8), BRCA1(4), BRCA2(3), FANCA(3), FANCE(1), FANCF(1), FANCG(2), MRE11A(1), RAD17(2), RAD50(1), TP53(11) 2014798 39 20 38 18 22 0 2 5 10 0 0.699 1.000 1.000 433 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(3), AGT(2), AGTR2(1), EDN1(2), EDNRA(3), EGF(4), EGFR(6), HRAS(2), MYC(2), NFKB1(4), PLCG1(1), PRKCA(5), RELA(1) 936261 36 20 36 23 28 3 2 2 1 0 0.631 1.000 1.000 434 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 APAF1(1), ATM(2), BAX(2), CASP7(2), CASP9(2), PRKCA(5), PTK2(2), STAT1(3), TLN1(5), TP53(11) 1245076 35 20 34 15 16 6 2 6 5 0 0.463 1.000 1.000 435 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(6), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), GNAS(4), HRAS(2), MAPK1(2), MAPK14(3), MAPK3(1), PIK3CA(3), PRKACB(1), PRKAR2B(3), PRKCA(5), RAC1(5), RPS6KA1(3), RPS6KA5(1), SOS1(3) 1324680 48 20 45 26 35 7 1 4 1 0 0.513 1.000 1.000 436 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDT1(1), DIAPH2(1), MCM2(4), MCM3(6), MCM5(1), MCM6(2), ORC1L(4), ORC5L(1), POLA2(2), POLD1(1), POLD2(1), POLD3(1), POLE(6), POLE2(1), RFC2(1), RPA4(1), UBC(2) 2309024 36 20 36 25 22 2 2 6 4 0 0.881 1.000 1.000 437 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 CABIN1(4), CALM1(1), CAMK1G(2), HDAC5(4), IGF1R(1), INSR(3), MAPK14(3), MAPK7(2), MEF2A(2), MEF2C(1), MEF2D(1), NFATC1(5), NFATC2(1), PIK3CA(3), SYT1(4) 1594067 37 20 37 33 25 6 1 3 2 0 0.970 1.000 1.000 438 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(5), ADC(2), AGMAT(1), ALDH18A1(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), AOC3(4), ARG2(1), ASL(1), ASS1(1), CPS1(8), GATM(1), MAOB(6), SMS(1) 1332430 45 20 45 24 23 6 3 6 7 0 0.385 1.000 1.000 439 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(3), ACAA1(2), ACAA2(1), ACADM(1), ACADS(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), AOX1(5), AUH(1), BCAT1(5), DLD(1), EHHADH(1), HADHA(1), HADHB(2), HIBCH(1), HMGCL(3), HMGCS2(7), HSD17B4(1), IVD(2), MCCC1(1), MCCC2(1), MUT(1), OXCT1(1) 1975191 53 20 52 27 32 6 0 8 7 0 0.582 1.000 1.000 440 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(4), FBP1(1), GOT2(1), GPT(1), GPT2(1), MDH2(2), ME1(4), ME3(2), PGK1(1), PGK2(4), PKLR(4), PKM2(1), TKT(1), TKTL2(4) 925358 32 20 31 26 24 2 2 4 0 0 0.809 1.000 1.000 441 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(1), GTF2A1L(1), GTF2E1(1), GTF2E2(2), GTF2F1(1), GTF2F2(1), GTF2H1(1), GTF2I(1), GTF2IRD1(3), TAF1(3), TAF1L(14), TAF2(1), TAF4(5), TAF5L(2), TAF6L(1), TAF7L(3), TAF9(1), TBPL1(1), TBPL2(1) 1652831 44 20 44 25 34 2 1 5 2 0 0.769 1.000 1.000 442 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(1), IFNA1(1), IFNB1(1), IL1A(3), IL1B(1), IL1R1(3), IL1RAP(2), IL1RN(1), IRAK2(4), IRAK3(1), MAP2K3(2), MAP3K14(2), MAP3K7(1), MAPK14(3), MYD88(2), NFKB1(4), NFKBIA(1), RELA(1), TRAF6(2) 1346889 36 20 36 21 24 1 2 5 4 0 0.654 1.000 1.000 443 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 CBL(2), CFLAR(1), E2F1(2), HRAS(2), IL2RB(3), JAK1(1), MAPK1(2), MAPK3(1), MYC(2), PIK3CA(3), PPIA(1), RAF1(3), RPS6KB1(1), SHC1(1), SOS1(3), STAT5A(1), STAT5B(1), SYK(4) 1648215 34 20 34 23 20 4 2 3 5 0 0.848 1.000 1.000 444 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(6), CAP1(1), CDC25C(1), GNAS(4), HRAS(2), MAPK1(2), MAPK3(1), MYT1(4), PIN1(1), PRKACB(1), PRKAR2B(3), RPS6KA1(3), SRC(1) 936592 30 20 30 24 17 5 1 4 3 0 0.898 1.000 1.000 445 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(1), CREBBP(4), EP300(7), IL1B(1), MAP2K3(2), MAP3K14(2), MAP3K7(1), MAPK14(3), MYD88(2), NFKB1(4), NFKBIA(1), NR3C1(3), RELA(1), TGFBR2(2), TLR2(4) 1358372 38 20 38 18 26 2 2 6 2 0 0.543 1.000 1.000 446 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(8), ATP5O(1), ATP6AP1(1), ATP6V0A1(4), ATP6V0A4(7), ATP6V1B2(2), ATP6V1C2(4), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(2), ATP7A(1), ATP7B(3), COX10(1), NDUFA10(2), NDUFB5(2), NDUFS2(1), SDHA(1), UQCRC1(1), UQCRFS1(1) 1752291 47 20 47 20 33 1 1 5 7 0 0.219 1.000 1.000 447 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(5), AXIN1(4), CREBBP(4), CTNNB1(3), EP300(7), FZD1(1), GSK3B(1), LEF1(1), TRRAP(9) 1519255 35 20 35 17 22 2 3 4 4 0 0.604 1.000 1.000 448 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(1), CHN1(2), LIMK1(1), MYL2(2), MYLK(11), NCF2(2), PDGFRA(9), PIK3CA(3), PLD1(3), PPP1R12B(3), RAC1(5), RPS6KB1(1), TRIO(4), VAV1(2) 1598964 49 20 45 36 37 2 3 4 3 0 0.933 1.000 1.000 449 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CHUK(1), EGR3(1), GNAQ(1), MYC(2), NFATC1(5), NFATC2(1), NFKB1(4), NFKBIA(1), PLCG1(1), PRKACB(1), PRKAR2B(3), RELA(1), SYT1(4), VIP(1), VIPR2(3) 1274274 31 20 31 23 23 3 2 2 1 0 0.868 1.000 1.000 450 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ABAT(3), ACADS(2), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH5A1(3), EHHADH(1), GAD1(4), GAD2(1), HADHA(1), HMGCL(3), L2HGDH(2), OXCT1(1), PDHA2(6), SDS(1) 1185870 40 19 40 19 27 4 1 6 2 0 0.317 1.000 1.000 451 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD1(1), DRD2(2), GRM1(7), PLCB1(18), PPP1R1B(1), PRKACB(1), PRKAR2B(3) 728005 33 19 32 26 28 1 2 1 1 0 0.799 1.000 1.000 452 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(1), BIRC3(1), CASP10(1), CASP7(2), CASP8(1), CASP9(2), CFLAR(1), CHUK(1), DFFB(1), GAS2(1), LMNA(1), MAP3K14(2), NFKB1(4), NFKBIA(1), RELA(1), SPTAN1(2), TNFRSF10A(2), TNFSF10(1), TNFSF12(1) 1526010 27 19 27 24 19 2 1 2 3 0 0.964 1.000 1.000 453 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), EGF(4), EGFR(6), ELK1(1), HRAS(2), JAK1(1), MAPK3(1), PIK3CA(3), PLCG1(1), PRKCA(5), RAF1(3), SHC1(1), SOS1(3), STAT1(3), STAT3(1), STAT5A(1) 1711091 37 19 37 27 23 7 1 5 1 0 0.951 1.000 1.000 454 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(5), EPHB1(8), FYN(1), ITGA1(11), ITGB1(2), L1CAM(3), LYN(2), RAP1B(1), SELP(10) 720453 43 19 42 20 36 0 1 4 2 0 0.274 1.000 1.000 455 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ANXA1(1), CALM1(1), GNAS(4), NFKB1(4), NOS3(2), NR3C1(3), PIK3CA(3), RELA(1), SYT1(4) 814508 23 19 23 18 17 3 0 3 0 0 0.943 1.000 1.000 456 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(1), GHR(7), HRAS(2), INSR(3), JAK2(1), MAPK1(2), MAPK3(1), PIK3CA(3), PLCG1(1), PRKCA(5), RAF1(3), RPS6KA1(3), SHC1(1), SLC2A4(4), SOS1(3), STAT5A(1), STAT5B(1) 1515037 42 19 42 24 29 6 1 4 2 0 0.545 1.000 1.000 457 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(3), ALDH4A1(1), ALDH5A1(3), CAD(5), CPS1(8), EPRS(3), GAD1(4), GAD2(1), GCLC(1), GCLM(2), GFPT1(1), GMPS(1), GOT2(1), GPT(1), GPT2(1), GSS(2), NADSYN1(2) 1515931 40 19 40 24 26 2 1 8 3 0 0.668 1.000 1.000 458 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(6), CALM1(1), ELK1(1), GNAQ(1), GNAS(4), HRAS(2), MAPK3(1), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), PLCG1(1), PRKACB(1), PRKAR2B(3), PRKCA(5), RAF1(3), SYT1(4) 1585661 47 19 47 33 28 9 3 5 2 0 0.884 1.000 1.000 459 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B10(2), ALDOA(1), ALDOB(4), FBP1(1), GMDS(1), GMPPB(1), HK2(5), HK3(3), MTMR1(1), MTMR6(1), PFKFB1(2), PFKFB2(1), PFKL(2), PGM2(2), PMM2(1), RDH11(1), RDH12(1), RDH13(1) 1689049 31 19 30 21 25 1 2 1 2 0 0.539 1.000 1.000 460 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(3), ADC(2), ALDH4A1(1), ALDH5A1(3), CAD(5), CPS1(8), EPRS(3), GAD1(4), GAD2(1), GCLC(1), GCLM(2), GFPT1(1), GLUD2(2), GMPS(1), GOT2(1), GPT(1), GPT2(1), GSS(2), NADSYN1(2) 1803415 44 19 44 27 26 3 2 8 5 0 0.675 1.000 1.000 461 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), AARS2(1), ABAT(3), ADSSL1(1), AGXT(1), AGXT2(3), ASL(1), ASNS(3), ASPA(1), ASS1(1), CAD(5), CRAT(2), DARS(2), DDO(4), DLAT(1), DLD(1), GAD1(4), GAD2(1), GOT2(1), GPT(1), GPT2(1), NARS(1), PC(1), PDHA2(6) 1729044 47 19 46 32 36 5 1 3 2 0 0.693 1.000 1.000 462 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(1), GLB1(2), HEXA(2), HEXB(2), LCT(13), SLC33A1(1), ST3GAL1(2), ST6GALNAC3(2), ST6GALNAC5(2), ST6GALNAC6(1), ST8SIA1(1), ST8SIA5(5) 752489 34 19 34 20 23 3 1 6 1 0 0.560 1.000 1.000 463 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ACTG2(1), ADCY3(1), ADCY9(1), ARF4(1), ATP6V0A1(4), ATP6V0A2(1), ATP6V0A4(7), ATP6V0D2(1), ATP6V1C2(4), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(2), ERO1L(1), GNAS(4), PDIA4(2), PLCG1(1), PLCG2(11), PRKCA(5) 1694159 56 19 56 36 40 4 1 4 7 0 0.524 1.000 1.000 464 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), ELK1(1), HRAS(2), JAK1(1), MAPK3(1), PDGFRA(9), PIK3CA(3), PLCG1(1), PRKCA(5), RAF1(3), SHC1(1), SOS1(3), STAT1(3), STAT3(1), STAT5A(1) 1593836 36 19 36 20 19 7 0 7 3 0 0.744 1.000 1.000 465 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 CASP9(2), CDC42(1), CHUK(1), ELK1(1), HRAS(2), MAPK3(1), NFKB1(4), PIK3CA(3), RAC1(5), RAF1(3), RALGDS(4), RELA(1) 861224 28 19 25 13 21 4 1 2 0 0 0.346 1.000 1.000 466 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT2(1), AKT3(2), GSK3B(1), IL4R(3), IRS2(1), JAK1(1), MAP4K1(4), MAPK1(2), MAPK3(1), PDK1(1), PIK3CA(3), PIK3CD(2), PPP1R13B(2), RAF1(3), SHC1(1), SOS1(3), SOS2(5), STAT6(4) 1670515 40 19 40 20 27 7 1 2 3 0 0.392 1.000 1.000 467 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(2), EGF(4), EGFR(6), HRAS(2), MAPK1(2), MAPK3(1), PTPRB(16), RAF1(3), SHC1(1), SOS1(3), SPRY1(1), SPRY3(3), SRC(1) 1139866 45 19 45 28 30 6 2 4 3 0 0.842 1.000 1.000 468 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(5), AXIN1(4), BTRC(3), CCND1(1), CREBBP(4), CSNK2A1(1), CTNNB1(3), FZD1(1), GSK3B(1), MAP3K7(1), MYC(2), NLK(2), PPARD(1), WIF1(4) 1334569 33 19 33 19 19 2 3 3 6 0 0.814 1.000 1.000 469 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), CARS(3), DARS(2), EPRS(3), FARS2(2), GARS(2), IARS(5), KARS(2), LARS(1), MARS2(2), NARS(1), RARS(4), SARS(1), WARS(3), WARS2(1), YARS(1) 1469564 34 18 33 14 25 2 2 2 3 0 0.261 1.000 1.000 470 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(6), CD3D(2), CD4(1), CREBBP(4), GNAS(4), HLA-DRA(3), HLA-DRB1(2), LCK(3), PRKACB(1), PRKAR2B(3), PTPRC(4), ZAP70(2) 1034141 35 18 35 28 25 5 1 3 1 0 0.936 1.000 1.000 471 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(6), GNAS(4), PRKAA1(1), PRKAA2(4), PRKAB1(1), PRKACB(1), PRKAG1(1), PRKAG2(4), PRKAR2B(3) 698101 25 18 24 19 15 4 1 2 3 0 0.919 1.000 1.000 472 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(6), CD3D(2), CD4(1), CREBBP(4), GNAS(4), HLA-DRA(3), HLA-DRB1(2), LCK(3), PRKACB(1), PRKAR2B(3), PTPRC(4), ZAP70(2) 1034141 35 18 35 28 25 5 1 3 1 0 0.936 1.000 1.000 473 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(1), CASP7(2), CASP8(1), CFLAR(1), DAXX(5), DFFB(1), LMNA(1), MAP3K7(1), PAK2(2), PRKDC(6), PTPN13(3), RB1(2), RIPK2(1), SPTAN1(2) 1865330 30 18 30 19 20 3 0 4 2 1 0.823 1.000 1.000 474 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 BCR(5), HRAS(2), JAK2(1), MAPK3(1), MYC(2), PIK3CA(3), RAF1(3), SOS1(3), STAT1(3), STAT5A(1), STAT5B(1) 1282401 25 18 25 16 14 5 1 5 0 0 0.836 1.000 1.000 475 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CARM1(2), CBS(2), GGT1(1), MARS2(2), MAT1A(1), METTL2B(2), PAPSS2(2), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(3), SEPHS1(2), SEPHS2(1) 1146816 25 18 25 14 16 3 2 3 1 0 0.528 1.000 1.000 476 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), CYP2C19(7), CYP2C9(12), DHRS1(2), DHRS2(1), DHRSX(2), EHHADH(1), ESCO2(2), HADHA(1), MYST3(1), MYST4(1), NAT6(1), SH3GLB1(1) 1414666 44 18 42 31 29 4 2 5 4 0 0.895 1.000 1.000 477 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA2(2), POLD1(1), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLG2(2), POLH(1), POLK(4), POLL(4), POLM(1), POLQ(9), PRIM2(3), REV1(1), REV3L(2) 1849007 39 18 39 16 18 0 5 11 5 0 0.437 1.000 1.000 478 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(2), AASDH(3), AASS(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), BBOX1(1), DOT1L(4), EHHADH(1), EHMT1(2), GCDH(1), HADHA(1), PLOD1(1), PLOD2(4), PLOD3(2), SDS(1) 1682527 36 18 36 16 21 5 0 6 4 0 0.270 1.000 1.000 479 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 HLA-A(2), IL18(2), ITGB1(2), KLRC3(3), KLRC4(2), KLRD1(1), MAPK3(1), PIK3CA(3), PTK2B(2), RAC1(5), SYK(4), VAV1(2) 846323 29 18 26 17 24 2 0 1 2 0 0.646 1.000 1.000 480 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(3), CCR2(6), CCR3(3), CCR4(2), CCR5(4), CD28(1), CD4(1), CXCR3(1), CXCR4(1), IFNGR1(2), IFNGR2(1), IL12B(1), IL12RB1(6), IL18R1(6), IL2(1), IL4(1), IL4R(3) 911023 43 18 42 29 32 2 1 4 4 0 0.554 1.000 1.000 481 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT2(1), GALNT3(1), GALNT4(2), GALNT6(4), GALNT7(2), GALNT8(5), GALNT9(1), GCNT1(2), ST3GAL1(2), WBSCR17(11) 661263 32 18 32 20 24 3 1 3 1 0 0.682 1.000 1.000 482 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CAMK1G(2), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CAMK4(3), ESRRA(1), HDAC5(4), MEF2A(2), MEF2C(1), MEF2D(1), PPARA(1), SLC2A4(4), SYT1(4) 919768 30 18 30 19 25 1 0 2 2 0 0.551 1.000 1.000 483 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(6), GNAS(4), PLCE1(15), PRKACB(1), PRKAR2B(3) 667959 29 18 28 25 19 5 2 2 1 0 0.954 1.000 1.000 484 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 GTF2A1(1), GTF2E1(1), GTF2F1(1), HDAC3(3), NCOA1(1), NCOA2(5), NCOA3(5), NCOR2(9), POLR2A(1), RARA(1), RXRA(2), TBP(2) 1134885 32 18 32 13 25 0 1 1 5 0 0.211 1.000 1.000 485 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), GNAQ(1), HTR2C(3), PLCB1(18), TUB(2) 326262 26 18 25 15 21 1 0 1 3 0 0.448 1.000 1.000 486 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(2), ACAA2(1), ACADL(3), ACADM(1), ACADS(2), ACADSB(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), AOX1(5), BCAT1(5), EHHADH(1), HADHA(1), HADHB(2), HMGCL(3), IVD(2), MCCC1(1), MCCC2(1), MUT(1), OXCT1(1), SDS(1) 1652460 46 18 46 25 31 4 0 5 6 0 0.643 1.000 1.000 487 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(11), AGT(2), AGTR1(2), AGTR2(1), BDKRB2(3), KNG1(4), NOS3(2), REN(1) 454627 26 17 26 19 15 3 1 4 3 0 0.705 1.000 1.000 488 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(3), ARFGAP3(1), ARFGEF2(9), CLTA(1), CLTB(1), COPA(2), GBF1(4), GPLD1(4) 747784 25 17 25 13 13 1 2 6 3 0 0.704 1.000 1.000 489 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(6), BAX(2), CSF2RB(3), IGF1R(1), KIT(3), KITLG(1), PIK3CA(3), PRKACB(1), PRKAR2B(3) 1001654 23 17 23 28 13 6 2 1 1 0 0.997 1.000 1.000 490 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(4), FBP1(1), GOT2(1), GPT(1), GPT2(1), MDH2(2), ME1(4), ME3(2), PGK1(1), PKLR(4), PKM2(1), TKT(1) 827182 24 17 23 14 17 1 2 4 0 0 0.492 1.000 1.000 491 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(13), NRG2(1), NRG3(6), PRKCA(5) 408170 25 17 24 12 21 3 0 0 1 0 0.379 1.000 1.000 492 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(5), CYP2A6(3), CYP2A7(2), NAT1(1), NAT2(1), XDH(13) 365991 27 17 27 19 19 2 4 0 2 0 0.485 1.000 1.000 493 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(5), IARS(5), IARS2(4), ILVBL(2), LARS(1), PDHA2(6), VARS(5) 862897 28 17 27 14 23 0 1 2 2 0 0.487 1.000 1.000 494 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(3), ACACA(6), ACACB(5), ACADM(1), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), EHHADH(1), HADHA(1), HIBCH(1), LDHAL6B(1), LDHC(3), MUT(1) 1818954 33 17 33 18 18 5 3 5 2 0 0.586 1.000 1.000 495 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), ABP1(5), AOC3(4), CES1(1), CES7(4), ESCO2(2), LIPA(1), MYST3(1), MYST4(1), NAT6(1), PLA1A(3), PRDX6(1), SH3GLB1(1) 1158210 26 17 26 25 19 2 1 2 2 0 0.992 1.000 1.000 496 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(4), CALM1(1), CAPN2(1), EP300(7), MEF2D(1), NFATC1(5), NFATC2(1), PRKCA(5), SYT1(4) 1120865 29 17 29 12 20 3 2 3 1 0 0.297 1.000 1.000 497 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 EIF4A2(2), EIF4B(2), EIF4G1(7), EIF4G3(6), FKBP1A(1), MKNK1(1), PDPK1(2), PIK3CA(3), PTEN(1), RPS6KB1(1), TSC1(1), TSC2(3) 1267790 30 17 29 15 16 5 2 2 5 0 0.629 1.000 1.000 498 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(1), IL1A(3), IL1R1(3), MAP3K14(2), MAP3K7(1), MYD88(2), NFKB1(4), NFKBIA(1), RELA(1), TLR4(8), TNFRSF1A(1), TNFRSF1B(2), TRAF6(2) 1096044 31 17 31 17 20 0 3 4 4 0 0.598 1.000 1.000 499 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 PIK3CA(3), PLCB1(18), PLCG1(1), PRKCA(5), VAV1(2) 588685 29 17 28 20 26 2 0 0 1 0 0.779 1.000 1.000 500 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT2(1), AKT3(2), MAPK1(2), MAPK3(1), PDK1(1), PIK3CA(3), PIK3CD(2), PTEN(1), PTK2B(2), RBL2(1), SHC1(1), SOS1(3) 939678 20 17 20 11 13 4 0 1 2 0 0.594 1.000 1.000 501 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(8), HLA-DRA(3), HLA-DRB1(2), IFNGR1(2), IFNGR2(1), IL12B(1), IL12RB1(6), IL18(2), IL18R1(6), IL2(1), IL4(1), IL4R(3) 577742 37 17 37 18 31 2 0 1 3 0 0.374 1.000 1.000 502 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 CASP9(2), CHUK(1), GH1(1), GHR(7), NFKB1(4), NFKBIA(1), PDPK1(2), PIK3CA(3), RELA(1) 640303 22 16 21 14 18 2 1 0 1 0 0.775 1.000 1.000 503 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ABAT(3), AGXT(1), AGXT2(3), ASL(1), ASNS(3), ASPA(1), CAD(5), CRAT(2), DARS(2), DDO(4), GAD1(4), GAD2(1), GOT2(1), GPT(1), GPT2(1), NARS(1), PC(1) 1193670 36 16 35 28 26 5 1 3 1 0 0.802 1.000 1.000 504 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(2), CREBBP(4), EP300(7), NCOA3(5), PRKACB(1), PRKAR2B(3), RARA(1), RXRA(2) 945934 25 16 25 11 16 1 2 2 4 0 0.482 1.000 1.000 505 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(4), EGFR(6), MAPK14(3), NCOR2(9), RARA(1), RXRA(2), THRB(4) 783964 29 16 29 18 24 0 1 3 1 0 0.693 1.000 1.000 506 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(2), CHIA(3), CHIT1(1), CTBS(1), GFPT1(1), GNE(1), HEXA(2), HEXB(2), HK2(5), HK3(3), MTMR1(1), MTMR6(1), NANS(1), PGM3(1) 1311080 25 16 25 11 19 1 0 5 0 0 0.338 1.000 1.000 507 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(1), BAIAP2(2), CASP1(1), CASP7(2), CASP8(1), GAPDH(1), INSR(3), ITCH(2), MAGI1(7), MAGI2(5), RERE(2), WWP1(1), WWP2(3) 1099037 31 16 31 26 25 2 0 2 2 0 0.968 1.000 1.000 508 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), ELK1(1), HRAS(2), IL2(1), IL2RB(3), JAK1(1), LCK(3), MAPK3(1), RAF1(3), SHC1(1), SOS1(3), STAT5A(1), STAT5B(1), SYK(4) 1054767 26 16 26 15 16 5 1 2 2 0 0.569 1.000 1.000 509 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(3), ACACA(6), ACADL(3), ACADM(1), ACADSB(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), EHHADH(1), HADHA(1), LDHC(3), MUT(1), SDS(1) 1518446 33 16 33 16 23 3 1 4 2 0 0.470 1.000 1.000 510 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 GLI2(9), GLI3(3), GSK3B(1), PRKACB(1), PRKAR2B(3), SHH(1), SMO(3), SUFU(1) 758888 22 16 22 17 14 5 2 1 0 0 0.811 1.000 1.000 511 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(1), IFNB1(1), JAK1(1), PTPRU(7), REG1A(2), STAT1(3), TYK2(3) 572063 18 16 18 10 11 0 0 5 2 0 0.632 1.000 1.000 512 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(1), HRAS(2), JAK2(1), MAPK3(1), MPL(3), PIK3CA(3), PLCG1(1), PRKCA(5), RAF1(3), SHC1(1), SOS1(3), STAT1(3), STAT3(1), STAT5A(1), STAT5B(1), THPO(2) 1367604 32 16 32 16 20 6 1 5 0 0 0.585 1.000 1.000 513 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(1), IL2(1), IL4(1), MAP3K5(7), MAPK14(3), NFKB1(4), NFKBIA(1), RELA(1), TNFRSF9(2) 877868 22 15 21 10 16 0 0 4 2 0 0.491 1.000 1.000 514 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CDKN1A(1), GNAQ(1), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), PLCG1(1), PRKCA(5), SP1(2), SYT1(4) 956308 29 15 29 13 20 4 2 1 2 0 0.349 1.000 1.000 515 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(6), CFTR(14), GNAS(4), PRKACB(1), PRKAR2B(3) 593364 28 15 27 27 17 4 2 3 2 0 0.976 1.000 1.000 516 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(4), FBP1(1), G6PD(1), PFKL(2), PGD(2), PGM1(1), PGM3(1), PRPS1L1(4), PRPS2(1), RBKS(1), TALDO1(1), TKT(1), TKTL2(4) 1107620 25 15 24 22 20 0 0 3 2 0 0.800 1.000 1.000 517 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), BHMT(1), CBS(2), DNMT1(6), DNMT3A(2), DNMT3B(3), MARS2(2), MAT1A(1), MTAP(1), MTR(2), TAT(2) 956517 23 15 23 12 13 2 4 2 2 0 0.541 1.000 1.000 518 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(4), PGAP1(1), PIGC(2), PIGF(1), PIGG(2), PIGK(1), PIGL(1), PIGN(1), PIGO(3), PIGQ(2), PIGS(1), PIGU(1), PIGV(2), PIGX(1), PIGZ(1) 1093158 24 15 24 16 16 1 2 4 1 0 0.683 1.000 1.000 519 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT3(1), B3GNT4(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), FUT2(1), FUT3(2), FUT5(1), FUT6(1), FUT9(7), ST3GAL6(1), ST8SIA1(1) 725080 19 15 19 11 12 3 2 1 1 0 0.468 1.000 1.000 520 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(4), EP300(7), FYN(1), IL7(2), IL7R(6), JAK1(1), LCK(3), PIK3CA(3), PTK2B(2), STAT5A(1), STAT5B(1) 1275208 31 15 31 17 20 2 2 3 4 0 0.706 1.000 1.000 521 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(1), ELK1(1), HRAS(2), INSR(3), MAPK3(1), PIK3CA(3), PTPN11(5), RAF1(3), SHC1(1), SLC2A4(4), SOS1(3) 1170120 27 15 26 17 14 7 0 4 2 0 0.833 1.000 1.000 522 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 BTK(4), GRASP(1), GSK3B(1), LYN(2), PDPK1(2), PFKL(2), PLCG1(1), PRKCE(2), PRKCZ(1), RAC1(5), RPS6KB1(1) 1134498 22 15 18 17 16 1 2 1 2 0 0.744 1.000 1.000 523 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BRAF(9), CREB3(1), CREB5(2), MAPK1(2), RAF1(3), SRC(1) 512369 18 15 15 10 11 1 1 3 2 0 0.674 1.000 1.000 524 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 JAK1(1), JAK2(1), PIAS3(3), PTPRU(7), REG1A(2), SRC(1), STAT3(1) 693082 16 15 16 14 10 1 0 2 3 0 0.884 1.000 1.000 525 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(3), APOA1(1), APOA4(2), APOC1(1), APOC2(1), APOE(1), CETP(1), CYP7A1(3), HMGCR(3), LDLR(2), LIPC(4), LPL(1), LRP1(13), SCARB1(1) 1260976 37 15 37 19 22 7 1 5 2 0 0.265 1.000 1.000 526 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(4), ARG2(1), ASL(1), CKMT2(1), CPS1(8), GAMT(2), GATM(1), OAT(2), PYCR1(1), SMS(1) 791856 22 15 22 11 15 2 0 3 2 0 0.423 1.000 1.000 527 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 NCKAP1(1), NTRK1(2), RAC1(5), WASF3(7), WASL(4) 701321 19 14 16 10 14 1 0 2 2 0 0.764 1.000 1.000 528 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 LCT(13), PGM1(1), PYGL(3), PYGM(5) 602317 22 14 22 14 15 2 0 4 1 0 0.543 1.000 1.000 529 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(6), ACACB(5), FASN(5), MCAT(1), OLAH(3) 726412 20 14 20 12 12 3 2 1 2 0 0.553 1.000 1.000 530 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(3), B3GALNT1(1), FUT2(1), FUT9(7), HEXA(2), HEXB(2), NAGA(1), ST3GAL1(2), ST8SIA1(1) 490032 20 14 20 12 13 3 0 2 2 0 0.499 1.000 1.000 531 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG7(2), BECN1(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(1), IFNA21(2), IFNA4(1), IFNA5(1), IFNA8(1), PIK3C3(1), PIK3R4(1), PRKAA1(1), PRKAA2(4), ULK1(2), ULK2(2) 953527 23 14 22 16 14 3 1 3 2 0 0.812 1.000 1.000 532 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(1), ELK1(1), HRAS(2), IGF1R(1), MAPK3(1), PIK3CA(3), PTPN11(5), RAF1(3), SHC1(1), SOS1(3) 1132012 21 14 20 12 9 8 0 3 1 0 0.754 1.000 1.000 533 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(4), EP300(7), LPL(1), NCOA1(1), NCOA2(5), PPARG(2), RXRA(2) 847505 22 14 22 10 15 1 1 2 3 0 0.618 1.000 1.000 534 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(5), AXIN1(4), BTRC(3), CTNNB1(3), DLL1(1), FZD1(1), GSK3B(1), NOTCH1(1) 966675 19 14 19 10 8 3 2 2 4 0 0.655 1.000 1.000 535 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), BIRC3(1), CASP10(1), CASP7(2), CASP8(1), CASP9(2), DFFB(1), PRF1(2), SCAP(1), SREBF1(3), SREBF2(1) 832423 16 14 16 17 12 2 1 1 0 0 0.968 1.000 1.000 536 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT2(1), AKT3(2), CDKN1A(1), ELK1(1), HRAS(2), NGFR(5), NTRK1(2), PIK3CA(3), PIK3CD(2), SHC1(1), SOS1(3) 732975 23 14 23 11 13 8 0 2 0 0 0.339 1.000 1.000 537 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(1), JAK2(1), PIAS3(3), PTPRU(7), REG1A(2) 624071 14 14 14 10 9 0 0 2 3 0 0.791 1.000 1.000 538 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(5), CREBBP(4), EP300(7), MAP3K7(1), MAPK3(1), TGFBR2(2) 1175736 20 14 20 13 11 2 1 4 2 0 0.945 1.000 1.000 539 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 MUSK(9), PIK3CA(3), PTK2(2), PTK2B(2), SRC(1), TERT(1) 740296 18 13 18 17 13 2 1 1 1 0 0.906 1.000 1.000 540 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(9), MAP2(6), PRKACB(1), PRKAG1(1), PRKAR2B(3), PRKCE(2) 829590 22 13 22 13 14 3 1 2 2 0 0.812 1.000 1.000 541 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CAMK1G(2), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CAMK4(3), CAMKK2(3), SYT1(4) 532987 19 13 19 14 17 1 0 0 1 0 0.619 1.000 1.000 542 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), ARHGDIB(1), BIRC3(1), CASP1(1), CASP10(1), CASP2(1), CASP7(2), CASP8(1), CASP9(2), DFFB(1), LMNA(1), PRF1(2) 893777 15 13 15 16 10 2 1 1 1 0 0.983 1.000 1.000 543 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CCL2(1), CCR5(4), CXCL12(1), CXCR4(1), GNAQ(1), MAPK14(3), PLCG1(1), PRKCA(5), PTK2B(2), SYT1(4) 631943 24 13 24 14 16 3 2 3 0 0 0.465 1.000 1.000 544 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), MAP3K14(2), NFKB1(4), NFKBIA(1), RELA(1), TRAF3(3), TRAF6(2) 826776 14 13 14 10 12 0 0 1 1 0 0.819 1.000 1.000 545 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 HRAS(2), MAPK1(2), MAPK3(1), MAPK7(2), MEF2A(2), MEF2C(1), MEF2D(1), NTRK1(2), PIK3CA(3), PLCG1(1), RPS6KA1(3), SHC1(1) 865160 21 13 21 15 13 6 0 1 1 0 0.753 1.000 1.000 546 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOA(1), ALDOB(4), FBP1(1), GCK(2), GMDS(1), GMPPB(1), HK2(5), HK3(3), PFKFB1(2), PMM2(1) 1089611 21 13 20 16 17 2 1 1 0 0 0.600 1.000 1.000 547 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(3), FUT2(1), FUT9(7), HEXA(2), HEXB(2), NAGA(1), ST3GAL1(2), ST8SIA1(1) 461348 19 13 19 11 12 3 0 2 2 0 0.461 1.000 1.000 548 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT7(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), CHST1(2), CHST2(3), CHST4(3), CHST6(2), FUT8(2), ST3GAL1(2) 567087 18 13 18 17 7 7 3 1 0 0 0.914 1.000 1.000 549 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(2), CHST12(2), CHST13(1), PAPSS2(2), SULT1A1(5), SULT1A2(1), SULT1E1(6), SULT2A1(4), SUOX(1) 417914 24 13 23 12 18 1 0 3 2 0 0.338 1.000 1.000 550 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 GSK3B(1), IGF1R(1), INPPL1(7), PDPK1(2), PIK3CA(3), PTEN(1), RPS6KB1(1) 899193 16 13 15 13 9 3 2 0 2 0 0.920 1.000 1.000 551 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(7), FYN(1), LRP8(2), RELN(15), VLDLR(3) 638237 28 13 28 22 21 0 1 3 3 0 0.958 1.000 1.000 552 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNGR1(2), JAK1(1), JAK2(1), PLA2G2A(1), PTPRU(7), REG1A(2), STAT1(3) 520758 17 13 17 10 9 0 0 5 3 0 0.823 1.000 1.000 553 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC3(1), CASP8(1), CFLAR(1), MAP3K3(1), MAP3K7(1), NFKB1(4), NFKBIA(1), NFKBIB(1), NFKBIL2(1), NR2C2(2), TNFRSF1A(1), TNFRSF1B(2) 1232522 17 13 17 13 11 2 1 2 1 0 0.872 1.000 1.000 554 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), CASP2(1), CASP8(1), DFFB(1), LMNA(1), MADD(3), MAP3K7(1), PAK2(2), PRKDC(6), RB1(2), SPTAN1(2), TNFRSF1A(1) 1771060 22 13 22 13 15 1 1 2 2 1 0.649 1.000 1.000 555 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(1), LTA(1), MAP3K14(2), NFKB1(4), NFKBIA(1), RELA(1), TNFRSF1B(2), TRAF1(2), TRAF3(3) 1021034 17 13 17 13 14 0 0 1 2 0 0.873 1.000 1.000 556 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(6), FHL5(4), FSHR(3), GNAS(4) 433275 17 12 17 17 11 3 0 3 0 0 0.983 1.000 1.000 557 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 MAPK3(1), OPRK1(10), POLR2A(1), PRKACB(1), PRKAR2B(3) 587321 16 12 16 11 12 2 2 0 0 0 0.623 1.000 1.000 558 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 IL4(1), MAP2K3(2), MAPK14(3), NFATC1(5), NFATC2(1), PRKACB(1), PRKAR2B(3) 552271 16 12 16 13 9 2 2 2 1 0 0.844 1.000 1.000 559 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(4), CLOCK(1), CRY1(1), CRY2(2), CSNK1E(1), NPAS2(3), PER1(3), PER3(1) 775856 16 12 16 13 9 2 1 1 3 0 0.899 1.000 1.000 560 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 HRAS(2), IGF1R(1), MAPK1(2), MAPK3(1), PIK3CA(3), RAF1(3), SHC1(1), SOS1(3) 870761 16 12 16 10 8 5 0 2 1 0 0.738 1.000 1.000 561 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(3), IL22RA1(2), JAK1(1), JAK2(1), STAT1(3), STAT3(1), STAT5A(1), STAT5B(1), TYK2(3) 833632 16 12 16 10 7 1 1 6 1 0 0.830 1.000 1.000 562 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(1), ELK1(1), HRAS(2), IL6ST(1), JAK1(1), JAK2(1), MAPK3(1), PTPN11(5), RAF1(3), SHC1(1), SOS1(3), STAT3(1) 1084381 21 12 20 11 8 7 0 4 2 0 0.694 1.000 1.000 563 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 CAT(1), GH1(1), GHR(7), HRAS(2), IGF1R(1), PIK3CA(3), SHC1(1) 607970 16 12 16 13 9 5 0 2 0 0 0.906 1.000 1.000 564 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(4), FBP1(1), G6PD(1), PGD(2), PGM1(1), PGM3(1), PRPS1L1(4), PRPS2(1), RBKS(1), TAL1(2), TALDO1(1), TKT(1) 933531 21 12 20 15 17 0 0 3 1 0 0.584 1.000 1.000 565 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(6), HSD17B2(2), HSD17B4(1), HSD17B7(1), HSD3B1(4) 367039 15 12 15 12 8 2 1 1 3 0 0.866 1.000 1.000 566 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), CYP2E1(5), NR1I3(2), PTGS1(5), PTGS2(3) 246037 17 11 17 10 13 0 0 0 4 0 0.441 1.000 1.000 567 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(4), HS3ST2(1), HS3ST3A1(2), XYLT1(5) 290205 12 11 12 13 6 3 0 2 1 0 0.920 1.000 1.000 568 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGAP5(3), ARHGDIB(1), CASP1(1), CASP10(1), CASP8(1), CASP9(2), PRF1(2) 592207 12 11 11 10 9 1 1 1 0 0 0.904 1.000 1.000 569 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EGF(4), EGFR(6), HGS(2), TF(2), TFRC(1) 587547 15 11 15 15 13 0 1 1 0 0 0.970 1.000 1.000 570 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(4), EGFR(6), ERBB3(1), NRG1(2) 470025 13 11 13 16 10 0 1 1 1 0 0.996 1.000 1.000 571 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(4), HS3ST2(1), HS3ST3A1(2), XYLT1(5) 290205 12 11 12 13 6 3 0 2 1 0 0.920 1.000 1.000 572 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(2), DHRS1(2), DHRS2(1), DHRSX(2), METTL2B(2), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(3) 688789 18 11 18 14 13 2 0 3 0 0 0.877 1.000 1.000 573 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(3), ACADM(1), ACADS(2), ACADVL(1), ACSL1(1), ACSL3(2), ACSL4(2), CPT1A(1), DCI(1), EHHADH(1), HADHA(1), SCP2(1) 776177 17 11 17 10 12 0 1 3 1 0 0.831 1.000 1.000 574 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 HRAS(2), NTRK1(2), PIK3CA(3), PLCG1(1), PRKCA(5), SHC1(1), SOS1(3) 713157 17 11 17 12 11 5 0 1 0 0 0.812 1.000 1.000 575 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(7), GNA12(1), PRKACB(1), PRKAG1(1), PRKAR2B(3) 461403 13 10 13 9 9 2 1 1 0 0 0.772 1.000 1.000 576 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(4), CDO1(2), GAD1(4), GAD2(1), GGT1(1) 260196 12 10 12 12 8 1 3 0 0 0 0.904 1.000 1.000 577 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(5), ATIC(2), FTCD(1), GART(2), MTR(2) 865658 12 10 11 7 11 0 1 0 0 0 0.608 1.000 1.000 578 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(7), CYP2C9(12) 91978 19 10 17 13 16 0 1 0 2 0 0.647 1.000 1.000 579 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(2), ACOX1(1), ACOX3(2), ELOVL5(1), FADS2(1), FASN(5), HADHA(1) 656478 13 10 13 12 7 0 1 2 3 0 0.897 1.000 1.000 580 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(1), MRPS7(1), RPL10L(3), RPL18(1), RPL18A(1), RPL19(1), RPL26(1), RPL35(1), RPL3L(2), RPS10(1), RPS18(1), RPS27(1), RPS7(1) 1032152 16 10 16 16 10 1 2 2 1 0 0.959 1.000 1.000 581 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 IFNAR1(1), IFNB1(1), NFKB1(4), RELA(1), TNFRSF11A(1), TNFSF11(1), TRAF6(2) 505644 11 10 11 9 11 0 0 0 0 0 0.856 1.000 1.000 582 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNAS(4), PRKACB(1), PRKAR2B(3), PRKCA(5) 433169 13 9 13 13 8 3 1 1 0 0 0.963 1.000 1.000 583 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(5), AOC3(4), CES1(1) 275772 10 9 10 12 6 1 1 1 1 0 0.952 1.000 1.000 584 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT2(1), FUT9(7), ST8SIA1(1) 272198 9 9 9 6 7 1 0 1 0 0 0.606 1.000 1.000 585 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(6), GNAS(4), PRKACA(1) 297324 11 9 11 10 5 3 0 3 0 0 0.924 1.000 1.000 586 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(2), DHRS1(2), DHRS2(1), DHRSX(2), PON1(4), RDH11(1), RDH12(1), RDH13(1) 413480 14 9 13 13 9 0 0 3 2 0 0.937 1.000 1.000 587 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACOT11(2), DHRS1(2), DHRS2(1), DHRSX(2), EHHADH(1), ESCO2(2), GCDH(1), HADHA(1), MYST3(1), MYST4(1), NAT6(1), SH3GLB1(1) 1191511 16 9 16 15 10 2 1 3 0 0 0.982 1.000 1.000 588 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(3), APOBEC1(1), APOBEC3A(1), APOBEC3B(1), APOBEC3F(2), APOBEC3G(2) 337913 10 9 10 9 7 1 1 1 0 0 0.889 1.000 1.000 589 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(1), BAX(2), BIK(1), BIRC3(1), CASP7(2), CASP8(1), CASP9(2), DFFB(1) 615482 11 9 11 6 7 3 1 0 0 0 0.678 1.000 1.000 590 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(2), DHRS2(1), DHRSX(2), ESCO2(2), MYST3(1), MYST4(1), NAT6(1), SH3GLB1(1) 758980 11 8 11 13 8 1 0 2 0 0 0.996 1.000 1.000 591 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(5), GOT2(1), TAT(2), TYR(3) 214561 11 8 11 8 9 1 1 0 0 0 0.729 1.000 1.000 592 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3D(2), IL2(1), IL4(1), TGFBR2(2), TGFBR3(2), TOB1(2) 481344 11 8 11 11 8 1 0 0 2 0 0.940 1.000 1.000 593 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(1), UBE2D3(1), UBE2E1(1), UBE2G2(1), UBE3A(4) 484788 9 8 9 5 6 1 0 2 0 0 0.721 1.000 1.000 594 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ASL(1), CPS1(8) 349176 9 8 9 6 7 0 0 2 0 0 0.766 1.000 1.000 595 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(3), CYP11B2(3), CYP17A1(1), HSD11B1(1), HSD11B2(1), HSD3B1(4) 314280 13 7 13 12 10 0 0 1 2 0 0.651 1.000 1.000 596 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 HRAS(2), PTK2B(2), SHC1(1), SOS1(3), SRC(1) 402255 9 7 9 6 6 2 0 1 0 0 0.740 1.000 1.000 597 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 IL4(1), IL4R(3), JAK1(1), RPS6KB1(1), SHC1(1), STAT6(4) 675845 11 7 11 11 6 1 1 0 3 0 0.931 1.000 1.000 598 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(4), CD28(1), CD3D(2), CD4(1) 145848 8 7 8 8 5 1 0 2 0 0 0.870 1.000 1.000 599 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), CD4(1), HLA-DRA(3), HLA-DRB1(2) 107163 7 6 7 5 7 0 0 0 0 0 0.548 1.000 1.000 600 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT1(1), B4GALT2(1), B4GALT3(1), FUT8(2), ST3GAL1(2) 358106 7 6 7 8 1 4 2 0 0 0 0.948 1.000 1.000 601 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(5), RANGAP1(1) 389239 6 6 6 4 4 1 0 1 0 0 0.876 1.000 1.000 602 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(3), ACADM(1), ACADS(2), HADHA(1) 251702 7 5 7 5 5 0 0 2 0 0 0.898 1.000 1.000 603 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(1), CSF1(3), LDLR(2), LPL(1) 243913 7 5 7 5 3 3 1 0 0 0 0.714 1.000 1.000 604 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(1), ALAS2(1), GATA1(1), HBB(1) 352170 4 4 4 4 4 0 0 0 0 0 0.832 1.000 1.000 605 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ7(1), NDUFA13(3) 181857 4 4 4 4 4 0 0 0 0 0 0.897 1.000 1.000 606 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(1), FUT2(1), FUT3(2) 326214 4 4 4 7 3 0 0 1 0 0 0.977 1.000 1.000 607 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1), FURIN(2), NOTCH1(1) 421503 4 4 4 6 2 2 0 0 0 0 0.935 1.000 1.000 608 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL1(2), ST8SIA1(1) 259482 3 3 3 7 2 1 0 0 0 0 0.987 1.000 1.000 609 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 POLD1(1), PRPS2(1), RRM1(1) 569599 3 3 3 7 2 0 0 1 0 0 0.992 1.000 1.000 610 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(3) 83733 3 2 3 3 3 0 0 0 0 0 0.862 1.000 1.000 611 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), HGD(1) 102952 2 2 2 3 2 0 0 0 0 0 0.917 1.000 1.000 612 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(1) 193914 1 1 1 3 1 0 0 0 0 0 0.981 1.000 1.000 613 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 75566 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 614 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 141850 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 615 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 70711 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 193352 0 0 0 3 0 0 0 0 0 0 1.000 1.000 1.000