Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Chi-square test_P	Chi-square test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
CDKN2A	12 (19%)	50	0.010129	1	0.84885	1	0.69476	1	0.32342	1	0.26603	1	0.50705	1	0.88776	1	0.8873	1
TP53	13 (21%)	49	0.36786	1	0.027648	1	1	1	0.075248	1	0.92748	1	0.48082	1	0.5334	1	0.061918	1
MUM1L1	13 (21%)	49	0.73665	1	0.62877	1	0.23512	1	0.32182	1	0.11346	1	0.051684	1	0.26567	1	0.80465	1
CD163L1	21 (34%)	41	0.83702	1	0.021264	1	1	1	0.20857	1	0.79158	1	0.6552	1	0.28914	1	0.84712	1
PSG4	12 (19%)	50	0.11028	1	1	1	1	1	0.37	1	0.77774	1	0.77168	1	0.24299	1	0.3894	1
PPP6C	10 (16%)	52	0.82233	1	0.68772	1	0.60499	1	0.22039	1	0.62397	1	0.61319	1	0.46864	1	0.43626	1
ZNF99	16 (26%)	46	0.20091	1	0.81705	1	0.32027	1	0.19571	1	0.057665	1	0.70184	1	0.67455	1	0.67081	1
KHDRBS2	10 (16%)	52	0.28706	1	0.23354	1	0.12739	1	0.69922	1	0.15045	1	0.059618	1	0.45621	1	0.59229	1
POTEG	10 (16%)	52	0.17941	1	0.62404	1	0.69476	1	0.096913	1	0.62397	1	0.49557	1	0.17265	1	0.67316	1
MARCO	13 (21%)	49	0.10701	1	0.42504	1	0.45058	1	0.99742	1	0.10354	1	0.060602	1	0.33223	1	0.29446	1
SGCZ	9 (15%)	53	0.80381	1	0.35391	1	0.020196	1	0.57815	1	1	1	0.65562	1	0.74064	1	1	1
GLRB	10 (16%)	52	0.77494	1	0.1111	1	0.40748	1	0.14119	1	0.42841	1	0.90444	1	0.61918	1	0.51237	1
OR2W1	8 (13%)	54	0.049477	1	0.079042	1	1	1	0.65466	1	0.8903	1	0.88974	1	0.12612	1	1	1
C4ORF22	7 (11%)	55	0.71156	1	1	1	0.10603	1	0.2607	1	0.18511	1	0.88338	1	0.94589	1	0.58083	1
UGT2B28	11 (18%)	51	0.79242	1	0.17744	1	0.69476	1	0.45601	1	0.77815	1	0.48689	1	0.20892	1	0.76755	1
ZNF676	11 (18%)	51	0.10152	1	0.64773	1	0.69476	1	0.55909	1	0.77815	1	1	1	0.90922	1	0.29944	1
LIPI	9 (15%)	53	0.83288	1	1	1	1	1	0.58948	1	0.18474	1	1	1	0.56519	1	0.85881	1
CADM2	8 (13%)	54	0.21378	1	0.35769	1	1	1	0.73075	1	0.72574	1	1	1	0.32969	1	0.01729	1
CDH9	11 (18%)	51	0.93776	1	0.11139	1	0.69476	1	0.37	1	0.4155	1	0.48689	1	0.69967	1	0.68302	1
OR52E2	7 (11%)	55	0.037438	1	0.77961	1	0.66142	1	0.81532	1	1	1	0.67665	1	1	1	0.712	1
CLEC5A	5 (8%)	57	0.23331	1	0.50894	1	0.10603	1	0.14389	1	0.24581	1	0.15483	1	0.17434	1	1	1
HIST1H2AA	5 (8%)	57	1	1	0.61239	1	1	1	0.7687	1	0.72948	1	0.4387	1	0.27737	1	0.11735	1
KIAA1257	8 (13%)	54	0.74999	1	0.45065	1	0.020196	1	0.57815	1	0.72574	1	1	1	0.61491	1	0.72849	1
PCDH18	16 (26%)	46	0.47707	1	0.93561	1	0.48012	1	0.37223	1	0.15408	1	0.61804	1	0.95463	1	0.30027	1
SPOCK3	9 (15%)	53	0.10123	1	0.14579	1	0.40748	1	0.28142	1	0.73031	1	0.53689	1	0.18641	1	0.33803	1
OR2G6	10 (16%)	52	0.79856	1	0.01629	1	1	1	0.25616	1	0.74989	1	0.61319	1	0.96424	1	0.32151	1
STXBP5L	14 (23%)	48	0.47218	1	0.30277	1	0.48012	1	0.91267	1	0.51284	1	0.29595	1	0.32298	1	0.90177	1
CNGB3	15 (24%)	47	0.65882	1	0.75373	1	0.0083617	1	0.19837	1	0.45444	1	0.18805	1	0.92952	1	0.23078	1
HHIPL2	4 (6%)	58	0.35351	1	0.13936	1	1	1	NA	NA	0.54511	1	0.66752	1	0.9094	1	1	1
OR10G8	6 (10%)	56	0.01371	1	0.14502	1	1	1	0.83921	1	0.014869	1	0.13233	1	0.62121	1	0.66789	1
UGT2B4	11 (18%)	51	0.91028	1	0.49309	1	1	1	0.67739	1	0.58951	1	0.22397	1	0.071693	1	1	1
ZBBX	11 (18%)	51	0.50712	1	1	1	1	1	0.52435	1	0.52885	1	0.18538	1	0.23243	1	1	1
C1QTNF9	6 (10%)	56	0.21312	1	0.75887	1	0.48718	1	NA	NA	0.87071	1	1	1	0.93341	1	0.24905	1
HCRTR2	9 (15%)	53	0.53048	1	0.039483	1	1	1	0.642	1	0.73031	1	0.53689	1	0.060585	1	0.33803	1
KRT78	7 (11%)	55	0.90264	1	0.10233	1	1	1	0.7687	1	0.46936	1	0.88338	1	0.64555	1	0.078974	1
BCLAF1	14 (23%)	48	0.76588	1	0.32901	1	0.71643	1	0.91365	1	0.86531	1	0.3931	1	0.31756	1	0.51329	1
LPAR1	6 (10%)	56	0.45752	1	0.19369	1	1	1	0.65466	1	0.15679	1	0.099146	1	0.14765	1	0.40753	1
STK31	10 (16%)	52	0.13918	1	0.23354	1	0.60499	1	0.17497	1	0.16684	1	0.49557	1	0.86326	1	1	1
HBG2	4 (6%)	58	0.42278	1	1	1	1	1	0.01527	1	0.83038	1	1	1	0.9094	1	1	1
BAGE2	4 (6%)	58	0.54066	1	0.82857	1	0.48718	1	NA	NA	0.088107	1	0.033115	1	0.38372	1	0.40688	1
ADH1B	6 (10%)	56	0.93769	1	0.42113	1	0.60499	1	0.6359	1	0.87071	1	1	1	0.32522	1	0.66789	1
CNTN4	12 (19%)	50	0.43814	1	0.78078	1	0.71643	1	0.56464	1	0.92252	1	1	1	1	1	0.14363	1
DEFA4	5 (8%)	57	1	1	0.36294	1	1	1	0.60707	1	0.20859	1	0.15483	1	0.74206	1	1	1
FAM117B	6 (10%)	56	0.74552	1	0.86777	1	0.60499	1	0.16176	1	0.48528	1	0.6328	1	0.93341	1	1	1
GFRAL	10 (16%)	52	0.42373	1	0.62404	1	0.34165	1	0.10482	1	0.031224	1	0.032527	1	0.60235	1	0.8668	1
ST8SIA3	8 (13%)	54	0.041561	1	0.40257	1	1	1	0.16943	1	1	1	0.71164	1	0.24903	1	1	1
DSPP	9 (15%)	53	0.28816	1	0.1646	1	1	1	0.36636	1	0.73031	1	0.53689	1	0.17035	1	0.85881	1
OR10K2	8 (13%)	54	0.3335	1	0.89341	1	0.66142	1	0.72948	1	0.35892	1	0.19312	1	0.37727	1	0.60747	1
CLEC17A	5 (8%)	57	0.32803	1	0.2116	1	1	1	0.43511	1	0.17622	1	0.4387	1	1	1	0.46955	1
POU6F2	9 (15%)	53	0.12744	1	0.2831	1	1	1	0.49703	1	1	1	1	1	0.92196	1	0.12978	1
LRRIQ3	10 (16%)	52	0.49783	1	0.83018	1	1	1	0.53371	1	0.067187	1	0.02303	1	0.96424	1	1	1
ARID2	11 (18%)	51	0.8144	1	1	1	1	1	0.30401	1	0.52885	1	0.22397	1	0.66549	1	0.35471	1
GAS2	7 (11%)	55	0.8193	1	0.77961	1	1	1	0.81436	1	0.60404	1	1	1	0.74257	1	0.11097	1
SIRPB1	6 (10%)	56	0.12129	1	0.75887	1	1	1	0.73075	1	0.64983	1	1	1	0.32522	1	0.24905	1
ACTC1	6 (10%)	56	0.78815	1	0.22394	1	0.60499	1	0.19095	1	0.36494	1	0.6328	1	0.53087	1	0.40753	1
PRB2	9 (15%)	53	0.31995	1	1	1	1	1	0.061194	1	0.54543	1	0.53689	1	0.859	1	0.85881	1
C15ORF23	4 (6%)	58	0.2585	1	0.1942	1	1	1	0.7687	1	1	1	1	1	0.10176	1	0.40688	1
FASLG	5 (8%)	57	0.050748	1	0.61239	1	1	1	0.65466	1	1	1	1	1	0.093996	1	0.16348	1
PAK7	12 (19%)	50	0.57671	1	0.52041	1	0.40748	1	0.36054	1	0.56454	1	0.29415	1	0.010058	1	0.25414	1
SIGLEC14	6 (10%)	56	0.19185	1	0.35701	1	1	1	NA	NA	0.56363	1	0.74556	1	0.27441	1	0.40753	1
TPTE2	8 (13%)	54	0.60064	1	0.80366	1	0.66142	1	0.58459	1	0.43924	1	0.55377	1	0.41824	1	0.72849	1
APBB1IP	6 (10%)	56	0.25011	1	1	1	0.48718	1	NA	NA	1	1	1	1	0.55956	1	0.24905	1
ANGPT1	8 (13%)	54	0.95582	1	0.56978	1	0.60499	1	0.73075	1	0.2525	1	0.06417	1	0.2071	1	1	1
ARL16	3 (5%)	59	0.11148	1	1	1	1	1	0.83921	1	1	1	0.78678	1	0.18041	1	0.26282	1
ARMC4	15 (24%)	47	0.80779	1	0.8694	1	1	1	0.47109	1	0.25876	1	0.1589	1	0.37689	1	0.65783	1
CD2	3 (5%)	59	0.88154	1	0.28157	1	1	1	NA	NA	0.62538	1	0.78678	1	0.27134	1	1	1
FRG2B	5 (8%)	57	0.15795	1	0.30547	1	1	1	0.50818	1	0.17622	1	0.26605	1	0.85942	1	0.16348	1
KRTAP12-1	3 (5%)	59	0.78001	1	0.62964	1	0.48718	1	NA	NA	0.4849	1	0.11666	1	0.51269	1	1	1
CYP4X1	7 (11%)	55	0.35268	1	0.41763	1	1	1	0.01527	1	0.77912	1	0.67665	1	0.74257	1	0.712	1
DSG1	14 (23%)	48	0.95181	1	0.80503	1	0.69476	1	0.074878	1	1	1	1	1	0.54135	1	0.90177	1
ADAM7	13 (21%)	49	0.29152	1	0.1604	1	0.18176	1	0.82106	1	0.033311	1	0.17241	1	0.46515	1	0.55753	1
KCNQ5	10 (16%)	52	0.96434	1	0.028652	1	1	1	0.2567	1	0.31165	1	0.14616	1	0.5083	1	0.031651	1
POF1B	10 (16%)	52	0.9013	1	0.83018	1	1	1	0.55125	1	1	1	0.378	1	0.67769	1	0.43626	1
TCEB3C	7 (11%)	55	0.78218	1	0.20552	1	1	1	0.16943	1	1	1	0.88338	1	0.012171	1	0.01502	1
F2RL1	6 (10%)	56	0.55567	1	1	1	1	1	0.60177	1	0.75757	1	1	1	0.028892	1	0.66789	1
SNCAIP	12 (19%)	50	0.065898	1	0.71739	1	1	1	0.78613	1	0.28696	1	0.07346	1	0.0034339	1	0.78398	1
LOC649330	8 (13%)	54	0.073779	1	0.6383	1	1	1	0.041685	1	0.2525	1	0.71164	1	0.71439	1	1	1
UGT2A3	8 (13%)	54	0.21378	1	0.50708	1	1	1	0.70057	1	0.3981	1	0.090922	1	0.023799	1	0.10227	1
C3ORF71	3 (5%)	59	0.40592	1	0.38152	1	1	1	0.34224	1	0.77255	1	0.78678	1	0.76388	1	0.15658	1
NDUFA13	4 (6%)	58	0.088482	1	0.25135	1	1	1	NA	NA	1	1	1	1	0.15539	1	0.40688	1
ZIM3	8 (13%)	54	0.071171	1	0.01995	1	1	1	0.056724	1	0.35892	1	0.30295	1	0.71439	1	1	1
DDX3X	7 (11%)	55	0.90264	1	0.77961	1	0.10603	1	0.13146	1	0.21145	1	0.67665	1	0.43752	1	0.712	1
LILRB4	8 (13%)	54	0.87793	1	1	1	1	1	0.78341	1	0.076374	1	0.55377	1	0.089696	1	0.85881	1
TLR4	11 (18%)	51	0.53145	1	0.28766	1	1	1	0.64227	1	0.91334	1	0.40217	1	0.6044	1	0.4167	1
ZNF479	5 (8%)	57	0.48561	1	0.0044687	1	0.23077	1	0.087438	1	0.61782	1	0.4387	1	0.043673	1	0.045501	1
GABRG1	8 (13%)	54	0.41489	1	0.56978	1	0.66142	1	0.35728	1	0.3981	1	0.30295	1	0.49287	1	0.72849	1
KLRC3	4 (6%)	58	0.70171	1	0.37561	1	0.60499	1	0.14389	1	1	1	1	1	0.13699	1	0.13935	1
OR1N2	7 (11%)	55	0.85981	1	0.17965	1	1	1	0.20125	1	0.1594	1	0.14147	1	0.0045546	1	0.057276	1
HHLA2	6 (10%)	56	0.55567	1	0.08182	1	0.047124	1	0.00013526	0.114	0.48528	1	0.21078	1	0.0018197	1	0.040879	1
SYCE1	6 (10%)	56	0.3427	1	0.56778	1	1	1	0.8087	1	0.064807	1	0.48899	1	0.47429	1	0.51799	1
RGPD3	12 (19%)	50	0.37077	1	0.61562	1	0.18176	1	0.17862	1	0.43486	1	1	1	0.48072	1	0.064676	1
CDH10	13 (21%)	49	0.31842	1	0.85858	1	0.69476	1	0.25289	1	0.92748	1	1	1	0.56702	1	0.80465	1
C6ORF105	5 (8%)	57	0.23331	1	1	1	1	1	0.35862	1	0.17622	1	0.26605	1	0.59901	1	0.35374	1
FPR2	5 (8%)	57	0.80477	1	0.72659	1	0.60499	1	0.58034	1	0.84646	1	0.62501	1	1	1	0.16348	1
UGT1A7	4 (6%)	58	1	1	1	1	1	1	0.65808	1	0.83038	1	0.66752	1	0.060676	1	1	1
JAKMIP1	9 (15%)	53	0.14628	1	0.4914	1	1	1	0.37736	1	0.66175	1	1	1	0.64371	1	0.64936	1
CYLC2	6 (10%)	56	0.3427	1	0.75887	1	1	1	0.47532	1	0.36494	1	0.13233	1	0.0095836	1	0.13495	1
DRGX	6 (10%)	56	0.52896	1	0.30257	1	1	1	0.66174	1	0.64983	1	0.6328	1	1	1	0.82933	1
IDH1	5 (8%)	57	0.30726	1	0.093027	1	1	1	0.65808	1	0.093531	1	1	1	0.050015	1	0.080095	1
ASB5	6 (10%)	56	0.61328	1	0.86777	1	1	1	0.60832	1	0.42371	1	0.21078	1	0.157	1	0.40753	1
COL21A1	11 (18%)	51	0.14882	1	0.84307	1	1	1	0.92066	1	0.91334	1	0.40217	1	0.47124	1	0.61459	1
OR4M2	7 (11%)	55	0.60346	1	0.47548	1	1	1	0.41263	1	0.77912	1	1	1	0.94589	1	0.37788	1
ANKRD45	7 (11%)	55	0.042341	1	0.53719	1	1	1	0.60077	1	1	1	0.45329	1	0.677	1	0.19811	1
LCE1B	5 (8%)	57	0.25045	1	0.85221	1	0.60499	1	0.69185	1	0.29898	1	1	1	0.27737	1	0.35374	1
MGAM	21 (34%)	41	0.83702	1	0.53105	1	1	1	0.42788	1	0.28979	1	0.73823	1	0.80506	1	0.43239	1
ACSM2B	9 (15%)	53	0.53048	1	0.54469	1	1	1	0.91292	1	0.20448	1	0.3264	1	0.11215	1	0.75021	1