rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(2), GRIA2(11), PPP1R1B(1) 332784 14 13 14 3 6 1 0 4 3 0 0.191 0.00301 1.000 2 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(4), FMOD(2), KERA(4), LUM(2) 319453 13 12 13 1 11 0 2 0 0 0 0.00801 0.00908 1.000 3 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 6 ADH1A(2), ADH1C(8), ADH4(2), ADH7(5), ADHFE1(3) 443633 20 17 18 5 14 1 1 3 1 0 0.101 0.0879 1.000 4 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(1), CASP3(1), CASP8(2), CFLAR(3), PDE6D(1) 357732 8 8 8 1 3 1 1 2 1 0 0.209 0.109 1.000 5 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT2(3), TAT(5) 240405 8 7 8 3 4 1 1 0 2 0 0.367 0.112 1.000 6 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(2) 46983 2 2 2 0 2 0 0 0 0 0 0.459 0.142 1.000 7 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(2), ALDH1A2(2), BCMO1(5), RDH5(1) 356527 10 10 9 3 8 0 0 2 0 0 0.210 0.288 1.000 8 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 CDK4(1), CDKN1A(3), E2F1(1), E2F2(2), MDM2(1), NXT1(1), PRB1(4) 639643 13 11 13 2 7 2 1 1 2 0 0.0479 0.305 1.000 9 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 65308 1 1 1 0 0 0 0 1 0 0 0.826 0.311 1.000 10 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(3), CDC25B(3), CDKN1A(3), NEK1(1) 636369 10 10 10 2 4 4 0 1 1 0 0.258 0.374 1.000 11 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(2), BAX(2), BCL2(1), BIRC2(2), BIRC3(1), CASP3(1), CASP7(3), CASP8(2), CASP9(1), CYCS(1), DFFB(1), DIABLO(1) 1232677 18 15 18 0 10 2 2 1 3 0 0.00124 0.375 1.000 12 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(2), ATM(4), BAX(2), BCL2(1), CDK4(1), CDKN1A(3), E2F1(1), MDM2(1), RB1(3), TIMP3(1) 1568183 19 15 19 3 6 4 1 2 6 0 0.0613 0.377 1.000 13 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(2), BAX(2), BCL10(1), BCL2(1), BCL2L11(4), CASP8AP2(3), CASP9(1), CES1(5) 987403 19 13 18 2 12 3 0 1 3 0 0.0151 0.377 1.000 14 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(1), CASP7(3), DFFB(1), GZMB(1), HMGB2(1), TOP2A(3), TOP2B(2) 820989 12 10 12 1 6 0 3 2 1 0 0.0821 0.379 1.000 15 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(3), CDC34(2), CUL1(1), E2F1(1), RB1(3), SKP2(1), TFDP1(1) 778812 12 11 12 2 7 1 2 0 2 0 0.0682 0.388 1.000 16 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(3), LPL(1), NR3C1(2), PPARG(3), RETN(1), RXRA(1) 531852 11 10 11 2 7 0 0 2 2 0 0.115 0.455 1.000 17 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(2), ACTR2(2), ACTR3(2), ARPC3(1), RAC1(3), WASF1(1), WASL(2) 743877 13 13 13 2 9 1 0 2 1 0 0.121 0.485 1.000 18 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(2), EGR1(2), HRAS(1), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), NGFR(3), RAF1(2) 738376 19 15 19 5 11 1 1 3 3 0 0.0833 0.561 1.000 19 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL1(2), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(1), ST6GALNAC4(1) 519299 7 7 7 2 3 1 1 2 0 0 0.395 0.605 1.000 20 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CDC34(2), CUL1(1), E2F1(1), FBXW7(1), RB1(3), TFDP1(1) 744549 9 9 9 2 3 1 2 0 3 0 0.195 0.614 1.000 21 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(2), GOT2(3), TAT(5) 428208 10 8 10 4 5 1 2 0 2 0 0.393 0.617 1.000 22 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT2(4), AKT3(2), CDKN1A(3), HRAS(1), MAP2K1(4), MAP2K2(1), NGFR(3), NTRK1(2), PIK3CA(1), PIK3CD(1), SOS1(1) 1456738 23 16 23 2 9 5 1 4 4 0 0.00528 0.619 1.000 23 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(2), ARHGDIB(3), BIRC2(2), BIRC3(1), CASP3(1), CASP7(3), CASP8(2), CASP9(1), CYCS(1), DFFB(1), GZMB(1), LMNB1(1), LMNB2(1), PRF1(3) 1783381 23 18 23 3 13 2 2 2 4 0 0.0197 0.637 1.000 24 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYB(1), RB1(3) 610339 5 5 5 0 1 0 1 1 2 0 0.158 0.640 1.000 25 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ICAM1(1), ITGAL(3), ITGAM(3), ITGB2(4), SELE(9), SELL(1) 938592 21 19 21 6 15 0 1 2 3 0 0.0891 0.643 1.000 26 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1), FUT2(2), FUT9(6) 548120 9 9 8 3 6 1 0 2 0 0 0.271 0.659 1.000 27 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA1(3), CCNE2(3), CDK4(1), E2F1(1), E2F2(2), PRB1(4) 766857 14 12 14 2 11 0 1 2 0 0 0.0515 0.666 1.000 28 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(2), ACOX3(2), ELOVL2(1), ELOVL6(1), FASN(5), HADHA(1), HSD17B12(1), SCD(2) 1310042 15 15 15 3 8 2 1 1 3 0 0.0413 0.691 1.000 29 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(3), CD34(2), CD3D(1), CD3G(1), CD58(1), CD8A(1), CSF3(2), IL6(1), KITLG(4) 559604 16 13 16 7 9 1 1 3 2 0 0.387 0.695 1.000 30 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(1), SNAP25(3), STX1A(1) 298217 5 4 5 0 3 0 0 1 1 0 0.130 0.702 1.000 31 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(1), CBS(4), MUT(1) 466792 6 6 6 0 5 1 0 0 0 0 0.0645 0.703 1.000 32 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOB(2) 360558 3 3 3 1 1 0 0 1 1 0 0.638 0.726 1.000 33 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 14 ABL1(3), E2F1(1), MDM2(1), MYC(2), PIK3CA(1), POLR1A(3), POLR1B(1), RAC1(3), RB1(3), TBX2(3) 1719499 21 16 21 3 11 3 1 3 3 0 0.0278 0.748 1.000 34 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1) 151284 1 1 1 0 0 0 0 1 0 0 0.819 0.750 1.000 35 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 ATM(4), CDC25A(3), CDC25B(3), CDC25C(2), CDK4(1), MYT1(7), RB1(3) 1528130 23 19 23 5 13 2 1 2 5 0 0.0899 0.759 1.000 36 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP14(1), MMP2(1), MMP9(2), RECK(1), TIMP3(1), TIMP4(1) 676964 8 8 8 1 4 0 0 3 1 0 0.227 0.772 1.000 37 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(2), IFNGR1(3), IFNGR2(1), JAK2(1), LIN7A(3), NFKB1(3), RB1(3), RELA(2), TNFRSF1A(1), TNFRSF1B(2), USH1C(3) 1570120 24 20 24 6 9 3 1 5 6 0 0.189 0.774 1.000 38 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(4), HLA-DRA(3), IL1B(2), IL5(1), IL5RA(2), IL6(1) 487091 13 11 13 6 10 0 0 1 2 0 0.255 0.775 1.000 39 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(2), ACADS(2), HADHA(1) 502346 7 7 7 3 5 0 1 1 0 0 0.574 0.775 1.000 40 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 CAMP(1), DAG1(4), GNAQ(1), ITPKB(2) 549272 8 8 8 1 6 0 0 0 2 0 0.0711 0.778 1.000 41 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 12 GALNT1(2), GALNT2(4), GALNT3(1), GALNT4(2), GALNT6(2), GALNT9(2), GCNT1(1), ST3GAL1(2), ST3GAL4(1) 1088454 17 15 17 3 11 1 0 4 1 0 0.0925 0.778 1.000 42 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ICAM1(1), ITGA4(5), ITGAL(3), ITGAM(3), ITGB1(1), ITGB2(4), SELE(9), SELL(1), SELP(8) 1440142 35 25 35 9 26 0 1 4 4 0 0.0366 0.783 1.000 43 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(8), CSF1(1), FCGR3A(2), IL1B(2), IL6R(2), SELL(1), SPN(1), TGFB1(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF8(4) 1181990 25 19 24 6 19 1 2 0 3 0 0.0224 0.791 1.000 44 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(4), GAD1(3), HDC(5), TH(1), TPH1(2) 548537 15 13 15 5 11 1 1 0 2 0 0.0923 0.793 1.000 45 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(4), HLA-DRA(3), IL5(1) 277269 8 7 8 6 6 0 0 0 2 0 0.567 0.799 1.000 46 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(2), NRF1(1), UBE2D3(1), UBE2E3(1), UBE2H(1), UBE2J2(2), UBE2L6(1), UBE2M(1), UBE2S(1), UBE3A(1) 966440 12 12 12 2 7 3 0 1 1 0 0.122 0.803 1.000 47 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2) 194865 2 2 2 1 1 0 0 1 0 0 0.786 0.809 1.000 48 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(4), EGFR(6), ERBB3(1), NRG1(5) 941215 16 13 16 3 11 0 2 3 0 0 0.132 0.819 1.000 49 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 14 ADH1A(2), ADH1C(8), ADH4(2), ADH5(1), ADH7(5), ADHFE1(3), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2) 1133721 29 23 27 9 19 2 4 3 1 0 0.0674 0.827 1.000 50 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), CD3D(1), CD3G(1), GZMB(1), HLA-A(2), ICAM1(1), ITGAL(3), ITGB2(4), PRF1(3) 793909 17 16 17 7 10 1 0 2 4 0 0.359 0.827 1.000 51 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 TGDS(1), UXS1(1) 354207 2 2 2 4 0 0 0 0 2 0 0.997 0.851 1.000 52 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD80(1), HLA-DRA(3), IL10(1), IL2(1) 360550 6 6 6 5 4 0 0 0 2 0 0.698 0.853 1.000 53 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1), SLPI(1) 157084 2 2 2 2 1 0 0 1 0 0 0.899 0.854 1.000 54 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(2), CDC25A(3), CDC25B(3), CDC25C(2), SHH(1) 797481 11 10 11 2 7 2 0 2 0 0 0.166 0.854 1.000 55 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(1), ENO2(2), ENO3(2), FARS2(2), GOT2(3), PAH(3), TAT(5) 761273 18 14 18 8 12 2 1 0 3 0 0.246 0.864 1.000 56 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 9 PARK2(2), SNCA(1), UBE2E2(2), UBE2F(1), UBE2L6(1) 415925 7 7 7 3 6 0 0 0 1 0 0.457 0.868 1.000 57 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(2), APAF1(2), BCL2(1), CASP3(1), CASP9(1), CYCS(1), DAXX(3), FAS(2), FASLG(5), IL1A(1), MAPKAPK2(2), MAPKAPK3(1) 1038936 22 17 22 5 15 3 1 2 1 0 0.0380 0.869 1.000 58 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(1) 167018 1 1 1 1 1 0 0 0 0 0 0.846 0.869 1.000 59 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(6), DFFB(1), GZMA(1), GZMB(1), HMGB2(1), PRF1(3) 970356 13 12 13 4 6 1 2 3 1 0 0.406 0.871 1.000 60 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD8A(1), CSF1(1), CSF3(2), EPO(1), IL2(1), IL5(1), IL6(1), IL7(2) 552100 10 9 10 4 7 1 0 1 1 0 0.290 0.873 1.000 61 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 HLA-DRA(3) 215913 3 3 3 3 2 0 0 0 1 0 0.809 0.878 1.000 62 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(3), CDC25B(3), CDC25C(2), PRKCA(1), PTPRA(2) 849283 11 11 11 3 7 3 0 1 0 0 0.165 0.892 1.000 63 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1G(3), HDAC9(6), MEF2A(2), MEF2B(1), MEF2C(1), MEF2D(2), MYOD1(1) 670741 16 10 16 5 11 1 0 2 2 0 0.253 0.892 1.000 64 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(3), PLCB1(13), PRKCA(1), RELA(2) 747672 20 16 19 7 15 1 0 3 1 0 0.254 0.893 1.000 65 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(4), CDC25A(3), CDC25B(3), CDC25C(2), MYT1(7) 1254755 19 17 19 5 12 2 0 2 3 0 0.207 0.894 1.000 66 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(2), ARHGAP5(3), ARHGDIB(3), CASP3(1), CASP8(2), CASP9(1), CYCS(1), GZMB(1), PRF1(3) 1180418 17 15 17 4 11 3 0 1 2 0 0.151 0.896 1.000 67 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(1), HLCS(2) 283461 3 3 3 2 3 0 0 0 0 0 0.702 0.898 1.000 68 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNAQ(1), HTR2C(4), PLCB1(13), TUB(3) 651875 21 15 20 8 19 0 0 1 1 0 0.153 0.908 1.000 69 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT2(2), FUT9(6), HEXA(1), HEXB(1), ST3GAL1(2), ST3GAL4(1) 923341 14 11 13 4 10 1 0 3 0 0 0.124 0.921 1.000 70 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ICAM1(1), ITGA4(5), ITGAL(3), ITGB1(1), ITGB2(4), SELE(9), SELL(1) 1093942 24 21 24 7 18 0 1 2 3 0 0.142 0.923 1.000 71 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SRP19(1), SRP68(3), SRPR(1) 699840 5 5 5 0 2 0 0 2 1 0 0.281 0.925 1.000 72 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CUL1(1), E2F1(1), RB1(3), SKP2(1), TFDP1(1), UBE2M(1) 785913 8 8 8 3 3 1 2 0 2 0 0.394 0.929 1.000 73 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 TGDS(1), UXS1(1) 451353 2 2 2 4 0 0 0 0 2 0 0.997 0.933 1.000 74 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO2(3), FH(1), IDH1(5), IDH2(1), MDH2(1) 819750 11 8 8 2 10 0 1 0 0 0 0.0688 0.933 1.000 75 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(6), F2(4), F2R(2), FGA(8), FGG(2), PLAT(3), PLG(8), SERPINB2(6) 1215849 40 28 40 13 31 2 5 2 0 0 0.0988 0.933 1.000 76 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(1), SQLE(1) 290616 2 2 2 0 2 0 0 0 0 0 0.371 0.937 1.000 77 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(3), ATM(4), ATR(4), CCNA1(3), CDC25A(3), CDK4(1), CDKN1A(3), E2F1(1), RB1(3), SKP2(1), TFDP1(1), TGFB1(1), TGFB3(1) 2619850 29 19 29 7 15 3 2 2 7 0 0.0643 0.940 1.000 78 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPL(1), ALPP(1), ALPPL2(4), FPGS(1) 584250 9 8 9 2 8 1 0 0 0 0 0.0726 0.941 1.000 79 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(1), POLR2A(4), POLR2B(3), POLR2E(1), POLR2F(1), POLR2J(1), POLR2L(1), POLRMT(1) 1217277 13 11 13 2 7 2 1 2 1 0 0.0618 0.941 1.000 80 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(3), G6PD(1), GCLC(2), GGT1(1), GPX5(3), GSS(1), GSTA1(1), GSTA2(1), GSTM1(1), GSTM4(1), GSTM5(3), GSTP1(1), GSTT1(1), IDH1(5), IDH2(1), PGD(2) 1645834 28 22 25 9 19 1 3 2 3 0 0.0387 0.944 1.000 81 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 APAF1(2), ATM(4), BAX(2), BCL2(1), CASP3(1), CASP7(3), CASP9(1), CYCS(1), PRKCA(1), PTK2(3), STAT1(2), TLN1(4) 2412879 25 19 25 4 13 4 2 2 4 0 0.0132 0.944 1.000 82 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(1), GBA3(6), GGT1(1), SHMT2(1) 487838 10 9 9 5 7 0 0 1 2 0 0.387 0.951 1.000 83 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(4), CDKN1A(3), EPO(1), EPOR(1), GRIN1(2), HIF1A(2), JAK2(1), NFKB1(3), RELA(2) 1142600 19 17 19 6 7 4 2 2 4 0 0.291 0.953 1.000 84 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(4), EGFR(6), MAP2K1(4), MAP3K1(1), NCOR2(8), RXRA(1), THRA(1), THRB(4) 1562980 29 22 29 7 16 4 3 4 2 0 0.0702 0.964 1.000 85 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF3(2), EPO(1), FLT3(6), IGF1(2), IL1A(1), IL6(1), KITLG(4), TGFB1(1), TGFB3(1) 751440 19 14 19 9 11 2 2 2 2 0 0.391 0.965 1.000 86 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BIRC3(1), CASP8(2), RIPK1(1), TNFRSF1A(1), TNFRSF1B(2) 748189 7 7 7 0 6 0 0 0 1 0 0.0520 0.966 1.000 87 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(5), GNAS(6), PRKACA(1) 591809 12 11 12 5 8 1 0 1 2 0 0.342 0.966 1.000 88 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR1(3), IFNGR2(1), JAK1(1), JAK2(1), STAT1(2) 744305 8 5 8 3 2 0 0 2 4 0 0.883 0.967 1.000 89 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2) 723594 10 10 10 4 7 0 2 1 0 0 0.315 0.967 1.000 90 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2) 723594 10 10 10 4 7 0 2 1 0 0 0.315 0.967 1.000 91 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(3), CCND2(1), CCNH(2), CDC25A(3), CDK4(1), CDKN1A(3), E2F1(1), RB1(3), RBL1(3), TFDP1(1) 1418872 21 16 21 6 11 2 2 3 3 0 0.122 0.967 1.000 92 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT1(5), B3GALT5(1), FUT2(2), FUT3(1), ST3GAL4(1) 653819 11 11 11 5 6 1 0 3 1 0 0.482 0.970 1.000 93 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(2) 386140 2 2 2 1 2 0 0 0 0 0 0.700 0.972 1.000 94 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(12), NRG3(6), PRKCA(1) 813864 19 17 18 8 13 1 1 0 4 0 0.342 0.972 1.000 95 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(5), FDPS(1), PMVK(1), SQLE(1) 1009689 8 8 8 2 5 1 0 1 1 0 0.278 0.976 1.000 96 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 IL12A(1), IL2(1) 267849 2 1 2 1 2 0 0 0 0 0 0.658 0.980 1.000 97 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(1), SQLE(1) 388533 2 2 2 0 2 0 0 0 0 0 0.380 0.981 1.000 98 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(2), BIRC2(2), BIRC3(1), CASP3(1), CASP7(3), CASP8(2), CASP9(1), DFFB(1), GZMB(1), PRF1(3), SCAP(1), SREBF1(1), SREBF2(4) 1661646 23 21 23 8 11 1 2 4 5 0 0.337 0.982 1.000 99 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), FARSA(1), FARSB(1), GOT2(3), PAH(3), TAT(5) 795508 15 14 15 9 10 1 1 0 3 0 0.583 0.985 1.000 100 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 27 CCR1(5), CCR3(4), CCR4(3), CCR7(1), CXCR3(1), CXCR4(1), IFNGR1(3), IFNGR2(1), IL12A(1), IL12RB1(3), IL12RB2(1), IL18R1(8), IL2(1), IL4R(6), IL5(1), TGFB1(1), TGFB3(1) 1740008 42 22 42 9 34 2 0 3 3 0 0.000403 0.986 1.000 101 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(1), APOBEC2(1), APOBEC3B(1), APOBEC3C(2), APOBEC3F(1), APOBEC3G(1) 673115 7 6 7 3 5 0 2 0 0 0 0.483 0.988 1.000 102 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(1), FECH(3) 690440 4 4 4 1 3 0 0 0 1 0 0.351 0.989 1.000 103 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(2), EPHA4(6), EPHB1(7), FYN(2), ITGA1(4), ITGB1(1), LYN(1), RAP1B(1), SELP(8) 1435816 32 22 31 10 21 1 0 6 4 0 0.0945 0.991 1.000 104 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACP6(1), ALPI(2), ALPL(1), ALPP(1), ALPPL2(4), CMBL(2), CYP3A4(4), CYP3A43(4), CYP3A5(3), CYP3A7(3), DHRS2(2), DHRS3(1), DHRSX(1), PON1(4) 1637007 34 23 34 11 22 2 1 4 5 0 0.0570 0.992 1.000 105 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(6), GGT1(1), SHMT2(1) 368819 8 8 7 5 6 0 0 1 1 0 0.503 0.992 1.000 106 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), HADHA(1), HSD17B4(1), SIRT5(2), VNN2(5) 1082882 10 9 10 4 5 1 1 1 2 0 0.487 0.992 1.000 107 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(3), EPHX2(1), HSD3B7(2), RDH13(1) 441033 7 6 7 7 5 0 1 0 1 0 0.906 0.992 1.000 108 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(3), FH(1), IDH2(1), OGDH(2) 865998 7 6 7 2 6 0 0 0 1 0 0.390 0.992 1.000 109 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(1), CPO(1), FECH(3), GATA1(1) 702304 6 6 6 3 5 0 0 0 1 0 0.488 0.992 1.000 110 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(5), FDPS(1), PMVK(1), SQLE(1) 1202919 8 8 8 2 5 1 0 1 1 0 0.310 0.993 1.000 111 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(2), HADHA(1), HADHB(3) 763632 6 6 6 3 1 1 1 1 2 0 0.760 0.994 1.000 112 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(1), CD36(1), FOS(1), FYN(2), THBS1(3) 676814 8 8 8 5 5 0 0 1 2 0 0.786 0.994 1.000 113 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST1(2), HS3ST2(3), XYLT1(3), XYLT2(1) 576714 10 10 10 5 7 0 0 3 0 0 0.473 0.994 1.000 114 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST1(2), HS3ST2(3), XYLT1(3), XYLT2(1) 576714 10 10 10 5 7 0 0 3 0 0 0.473 0.994 1.000 115 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(3), DHRS2(2), DHRS3(1), DHRSX(1), HSD3B7(2), PON1(4), RDH13(1) 826595 14 10 14 7 8 1 1 2 2 0 0.510 0.994 1.000 116 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(5), AOC2(2), AOC3(2), CES1(5) 548751 14 12 13 9 11 0 0 1 2 0 0.616 0.994 1.000 117 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS2(1), SULT1A2(1), SULT1E1(3), SULT2A1(2), SUOX(1) 556824 8 5 8 3 7 0 0 1 0 0 0.440 0.994 1.000 118 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(6), JAK1(1), JAK2(1), TYK2(3) 952137 11 10 11 4 9 0 0 0 2 0 0.477 0.995 1.000 119 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(6), JAK1(1), JAK2(1), TYK2(3) 952137 11 10 11 4 9 0 0 0 2 0 0.477 0.995 1.000 120 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(4), GGT1(1), PAPSS2(1), SCLY(1), SEPHS1(2) 1140675 9 9 9 2 5 1 0 3 0 0 0.203 0.995 1.000 121 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 16 HLA-DRA(3), IFNGR1(3), IFNGR2(1), IL12A(1), IL12RB1(3), IL12RB2(1), IL18R1(8), IL2(1), IL2RA(1), IL4R(6) 1093455 28 15 28 8 22 2 0 1 3 0 0.0610 0.995 1.000 122 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(4), FOS(1), HRAS(1), MAP2K1(4), MAPK1(3), MAPK3(1), MYC(2), NFKB1(3), PLCB1(13), PRKCA(1), RAF1(2), RELA(2) 1420277 37 26 36 13 25 1 1 5 5 0 0.130 0.995 1.000 123 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(1), CARS2(1), CDO1(1), GOT2(3), LDHA(2), LDHAL6B(2), SULT1B1(2), SULT1C2(3), SULT1C4(1), SULT4A1(3) 1147350 19 17 19 8 13 1 2 2 1 0 0.373 0.995 1.000 124 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(5), PGAP1(2), PIGB(2), PIGF(1), PIGG(3), PIGH(1), PIGK(3), PIGO(3), PIGQ(1), PIGT(1), PIGU(2), PIGV(2), PIGZ(1) 2187391 27 22 27 7 18 2 0 3 4 0 0.0373 0.995 1.000 125 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ASL(3), CPS1(4) 696291 7 7 7 4 5 0 0 1 1 0 0.655 0.995 1.000 126 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 EIF4A1(1), EIF4A2(1), EIF4B(1), EIF4G1(3), EIF4G2(1), EIF4G3(2), FKBP1A(1), PIK3CA(1), PPP2CA(1), PTEN(4), RPS6(1), RPS6KB1(1), TSC1(1), TSC2(6) 2528227 25 18 25 8 7 4 4 3 6 1 0.374 0.995 1.000 127 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 HADHA(1), HADHB(3), HSD17B4(1), MECR(1), PPT1(1), PPT2(1) 774973 8 8 8 4 1 0 2 2 3 0 0.741 0.996 1.000 128 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(2), ADORA2A(1), ADORA2B(1), ADORA3(2), LTB4R(1), P2RY2(2) 543586 9 9 9 6 5 0 0 3 1 0 0.524 0.996 1.000 129 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), CYP2E1(1), NR1I3(1), PTGS1(3), PTGS2(3) 491917 10 7 10 7 7 1 0 1 1 0 0.626 0.996 1.000 130 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1) 424912 1 1 1 1 1 0 0 0 0 0 0.893 0.996 1.000 131 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(1), IL1B(2), MST1(1), MST1R(3) 598617 7 6 7 4 4 2 0 0 1 0 0.689 0.997 1.000 132 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PRKCA(1), TGM2(1) 454737 2 2 2 2 1 0 0 0 1 0 0.745 0.997 1.000 133 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALT5(1), FUT2(2), FUT9(6), HEXA(1), HEXB(1), ST3GAL1(2) 980789 14 11 13 6 10 1 0 3 0 0 0.310 0.997 1.000 134 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 CYCS(1), GPD2(1), SDHC(1) 608704 3 3 3 1 3 0 0 0 0 0 0.564 0.997 1.000 135 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT5(2), FUT8(1), ST3GAL1(2), ST3GAL4(1) 716297 6 6 6 3 3 1 0 2 0 0 0.717 0.997 1.000 136 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(2), B3GAT3(1), CHPF(1), CHST11(1), CHST12(1), CHST3(1), CHSY1(1), DSE(7), XYLT1(3), XYLT2(1) 1215035 19 14 19 8 11 3 1 2 2 0 0.215 0.997 1.000 137 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(2), ACTR2(2), ACTR3(2), ARPC3(1), NCK1(1), NCKAP1(2), NTRK1(2), RAC1(3), WASF1(1), WASL(2) 1401108 18 18 18 5 12 1 0 3 2 0 0.295 0.998 1.000 138 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1), FURIN(3), NOTCH1(1) 843223 5 4 5 1 1 1 0 3 0 0 0.438 0.998 1.000 139 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 MYC(2) 572664 2 2 2 0 2 0 0 0 0 0 0.406 0.998 1.000 140 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(3), ATM(4), BRCA1(3), CDKN1A(3), MDM2(1), MRE11A(1), NFKB1(3), RELA(2), TP73(2) 2629281 22 20 22 5 8 4 1 4 5 0 0.199 0.998 1.000 141 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(1), NDUFB2(1), NDUFB5(1) 639968 3 3 3 1 3 0 0 0 0 0 0.576 0.998 1.000 142 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CSF1(1), CSF3(2), HLA-DRA(3), IFNB1(2), IL10(1), IL12A(1), IL15(1), IL1A(1), IL2(1), IL5(1), IL6(1), IL7(2), TGFB1(1), TGFB3(1) 1199617 19 14 19 9 13 1 1 2 2 0 0.266 0.998 1.000 143 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACO2(3), ACSS2(1), FH(1), IDH1(5), IDH2(1), MDH2(1) 1221803 12 9 9 3 10 0 1 0 1 0 0.0922 0.998 1.000 144 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO2(3), GRHPR(1), HAO1(2), HAO2(4), MDH2(1), MTHFD1(2) 1167312 13 12 13 5 9 1 1 1 1 0 0.277 0.998 1.000 145 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(3), EIF2AK4(3), EIF2B5(1), EIF5(1) 1064334 8 8 8 3 3 1 0 4 0 0 0.644 0.999 1.000 146 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(2), ATP6V0A4(8), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(3), ATP6V1G3(1), ATP6V1H(1), FDXR(2) 1462391 20 15 20 8 6 3 3 3 5 0 0.311 0.999 1.000 147 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(1), IL1A(1), IL1R1(5), NR4A3(2), WDR1(1) 972824 10 9 10 4 7 0 1 0 2 0 0.472 0.999 1.000 148 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 FOS(1), MAFG(1), MAPK1(3), NFE2L2(1), PRKCA(1) 809863 7 6 7 5 5 0 0 0 2 0 0.777 0.999 1.000 149 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(1), GOT2(3), LDHA(2) 626901 6 5 6 5 3 1 1 0 1 0 0.861 0.999 1.000 150 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO2(3), GRHPR(1), HAO1(2), HAO2(4), MDH2(1), MTHFD1(2) 1223009 13 12 13 5 9 1 1 1 1 0 0.271 0.999 1.000 151 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 EIF2B5(1), IGF1(2), IGF1R(1), INPPL1(4), PIK3CA(1), PPP2CA(1), PTEN(4), RPS6(1), RPS6KB1(1) 1792198 16 15 16 5 2 4 2 3 5 0 0.492 0.999 1.000 152 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 BCL2(1), EGFR(6), IGF1R(1), MYC(2), POLR2A(4), PPP2CA(1), PRKCA(1), RB1(3), TEP1(6), TERT(1), XRCC5(1) 2481590 27 21 27 7 15 2 4 3 3 0 0.0744 0.999 1.000 153 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 APC(4), AXIN1(2), CD14(2), CTNNB1(1), FZD1(1), GJA1(2), IRAK1(1), LBP(2), LEF1(1), MYD88(1), NFKB1(3), PIK3CA(1), PPP2CA(1), RELA(2) 2615082 24 18 24 6 10 4 4 2 4 0 0.122 0.999 1.000 154 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), LARS(2), LARS2(2), PDHA1(1), PDHA2(2), PDHB(1) 917661 9 7 8 5 3 3 0 1 2 0 0.777 0.999 1.000 155 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 GTF2A1(1), GTF2B(3), GTF2E1(1), GTF2F1(1), HDAC3(3), NCOA1(2), NCOA3(2), NCOR2(8), POLR2A(4), RXRA(1), TBP(1) 2261262 27 19 27 8 15 2 2 4 4 0 0.178 0.999 1.000 156 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 BDH1(1), HMGCL(1), HMGCS2(3), OXCT1(1) 650980 6 4 6 8 2 2 0 1 1 0 0.989 0.999 1.000 157 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EGF(4), EGFR(6), TF(3), TFRC(1) 1171089 14 9 14 4 10 0 2 2 0 0 0.268 1.000 1.000 158 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(2), ATP6V0A4(8), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(3), ATP6V1G3(1), ATP6V1H(1) 1373936 18 15 18 8 6 2 3 2 5 0 0.388 1.000 1.000 159 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(2), ATP6V0A4(8), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(3), ATP6V1G3(1), ATP6V1H(1) 1373936 18 15 18 8 6 2 3 2 5 0 0.388 1.000 1.000 160 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(2), ATP6V0A4(8), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(3), ATP6V1G3(1), ATP6V1H(1) 1373936 18 15 18 8 6 2 3 2 5 0 0.388 1.000 1.000 161 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(3), POLR1B(1), POLR2A(4), POLR2B(3), POLR2E(1), POLR2F(1), POLR2J(1), POLR2L(1), POLR3A(1), POLR3B(2) 2140300 18 16 18 4 11 1 1 3 2 0 0.0910 1.000 1.000 162 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(2), ENO1(1), HK1(1), PKLR(2) 841089 6 5 6 4 4 1 0 0 1 0 0.613 1.000 1.000 163 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(1), JAK2(1), JAK3(2), MAPK1(3), MAPK3(1), TYK2(3) 1059518 11 7 11 6 7 0 0 1 3 0 0.644 1.000 1.000 164 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(5), ATM(4), BAX(2), CDKN1A(3), CPB2(1), CSNK1A1(1), HIF1A(2), IGFBP3(2), MDM2(1) 1819007 21 16 20 7 12 3 1 2 3 0 0.295 1.000 1.000 165 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 CBS(4), DNMT1(5), DNMT3A(3), DNMT3B(3), MTR(1) 1613540 16 11 16 3 12 2 1 0 1 0 0.0476 1.000 1.000 166 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(2), MBTPS1(3), SCAP(1), SREBF1(1), SREBF2(4) 1081212 11 10 11 9 4 0 0 4 3 0 0.942 1.000 1.000 167 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(6), DAXX(3), HRAS(1), PAX3(1), PML(2), RB1(3), SP100(1), TNFRSF1A(1), TNFRSF1B(2) 1640742 20 14 20 7 8 2 3 2 5 0 0.455 1.000 1.000 168 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 BCAR1(1), ITGB1(1), MAPK1(3), MAPK3(1), PIK3CA(1), PTEN(4), PTK2(3), SOS1(1) 1751944 15 12 15 9 5 2 0 3 5 0 0.907 1.000 1.000 169 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(3), EGF(4), EGFR(6), HRAS(1), MAP2K1(4), MAPK1(3), MAPK3(1), PTPRB(25), RAF1(2), RASA1(3), SOS1(1), SPRY1(3), SPRY3(1), SPRY4(1) 2273958 58 32 55 15 41 5 2 4 6 0 0.0179 1.000 1.000 170 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR1B(2) 572987 2 2 2 2 1 0 0 1 0 0 0.919 1.000 1.000 171 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(4), ATR(4), CDC25C(2) 1382901 10 10 10 4 7 0 0 0 3 0 0.627 1.000 1.000 172 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(3), CHPT1(1), HEMK1(1), LCMT1(1), METTL2B(2), PCYT1B(2), PRMT3(2), PRMT8(1) 1282463 13 11 13 5 7 0 1 4 1 0 0.415 1.000 1.000 173 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(2), ACTR3(2), ARPC3(1), PAK1(1), PDGFRA(7), PIK3CA(1), RAC1(3), WASL(2) 1225772 19 17 19 8 11 2 0 3 3 0 0.586 1.000 1.000 174 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(2), PRKCA(1) 615441 3 3 3 7 2 0 0 0 1 0 0.993 1.000 1.000 175 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNB1(2), JAK1(1), STAT1(2), TYK2(3) 982953 8 7 8 3 6 0 0 1 1 0 0.442 1.000 1.000 176 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), MIOX(2) 771069 10 10 10 5 5 2 3 0 0 0 0.523 1.000 1.000 177 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(3), CASP3(1), CASP8(2), CRADD(1), DFFB(1), LMNB1(1), LMNB2(1), MADD(7), MAP2K4(1), MAP3K1(1), MAP3K7(1), PAK1(1), PRKDC(3), RB1(3), RIPK1(1), SPTAN1(1), TNFRSF1A(1) 3556404 30 20 30 7 13 3 2 3 9 0 0.0580 1.000 1.000 178 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(3), HK1(1), HK2(1), HK3(2), TGDS(1) 935732 8 8 8 9 3 3 0 0 2 0 0.958 1.000 1.000 179 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(9) 777392 9 8 9 5 6 1 0 1 1 0 0.794 1.000 1.000 180 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT2(4), AKT3(2), MAPK1(3), MAPK3(1), PDK1(1), PIK3CA(1), PIK3CD(1), PTEN(4), RBL2(1), SOS1(1) 1873851 19 16 19 9 7 3 0 4 5 0 0.645 1.000 1.000 181 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), IL10(1), IL10RB(4), IL1A(1), IL6(1), JAK1(1), STAT1(2) 1116786 11 10 10 8 5 0 1 2 3 0 0.867 1.000 1.000 182 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNGR1(3), JAK1(1), JAK2(1), PTPRU(2), REG1A(1), STAT1(2) 1041573 10 6 10 7 4 1 0 2 3 0 0.920 1.000 1.000 183 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 ACTR2(2), ACTR3(2), DAG1(4), DGKA(1), GCA(2), ITGA9(2), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(2), MAP2K1(4), MAPK1(3), MAPK3(1), NR1I3(1), PAK1(1), PDE3A(8), PDE3B(1), PI3(1), PIK3CA(1), PIK3CD(1), RIPK3(2), VASP(1) 4199606 54 30 53 10 33 6 2 4 9 0 0.000156 1.000 1.000 184 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT3(1), B3GNT4(1), B4GALT4(2), FUT2(2), FUT3(1), FUT4(2), FUT7(2), FUT9(6), ST3GAL6(1) 1453611 19 17 18 9 10 4 0 3 2 0 0.315 1.000 1.000 185 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ME1(3), PC(3), PDHA1(1), SLC25A11(1) 851090 8 7 8 5 5 2 1 0 0 0 0.620 1.000 1.000 186 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(4), AXIN1(2), CTNNB1(1), DLL1(1), FZD1(1), NOTCH1(1) 1925810 10 9 10 3 3 2 1 0 4 0 0.376 1.000 1.000 187 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 HRAS(1), SOS1(1) 805026 2 2 2 7 1 0 0 0 1 0 1.000 1.000 1.000 188 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(2), BCL2(1), CASP8(2), CYCS(1), MAP2K1(4), MAP2K4(1), MAP3K1(1), MAPK1(3), MAPK3(1), NFKB1(3), NSMAF(2), RAF1(2), RELA(2), RIPK1(1), SMPD1(1), TNFRSF1A(1) 1859550 28 18 28 8 16 3 0 5 4 0 0.162 1.000 1.000 189 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA3(3), ANXA5(1), ANXA6(1), CYP11A1(4), EDNRA(2), EDNRB(1), HPGD(1), HSD11B1(3), HSD11B2(1), PLA2G4A(2), PRL(1), PTGDR(2), PTGER2(1), PTGER4(1), PTGFR(6), PTGIS(5), PTGS1(3), PTGS2(3), TBXAS1(2) 1863478 43 26 43 19 27 5 0 7 4 0 0.177 1.000 1.000 190 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(4), CREBBP(6), EP300(4), MAP2K1(4), MAP3K7(1), MAPK3(1), TGFB1(1), TGFB3(1), TGFBR2(3) 2346256 25 21 25 8 14 2 1 3 5 0 0.427 1.000 1.000 191 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO2(3), DLD(1), FH(1), IDH1(5), IDH2(1), IDH3A(1), MDH2(1), PC(3), PCK1(4), SUCLG1(1) 1890667 21 18 18 8 16 0 3 1 1 0 0.181 1.000 1.000 192 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 5 C3(11), C5(3), C6(14), C7(11), C8A(9) 1022874 48 26 45 19 34 2 2 2 8 0 0.112 1.000 1.000 193 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(3), HK1(1), HK2(1), HK3(2), TGDS(1) 1064934 8 8 8 9 3 3 0 0 2 0 0.954 1.000 1.000 194 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA5(1), PSMB5(1), PSMB8(2) 806242 4 4 4 3 1 0 0 2 1 0 0.938 1.000 1.000 195 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(3), CYP2A6(5), CYP2A7(2), NAT2(1), XDH(14) 733017 27 19 25 15 23 1 1 2 0 0 0.179 1.000 1.000 196 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(6), EP300(4), ESR1(1), MAPK1(3), MAPK3(1), PELP1(2) 1337367 17 14 17 7 10 2 1 2 2 0 0.488 1.000 1.000 197 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 IL2RG(1), IL4R(6), IRS1(3), JAK1(1), JAK3(2), RPS6KB1(1), STAT6(1) 1344153 15 11 15 5 7 1 2 2 3 0 0.331 1.000 1.000 198 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CAPN1(1), CDK5(2), CSNK1A1(1), MAPT(3), PPP2CA(1) 821024 8 7 8 6 3 0 1 3 1 0 0.881 1.000 1.000 199 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ENPP3(4), FLAD1(2) 882618 7 7 7 9 3 1 1 1 1 0 0.980 1.000 1.000 200 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(3), CKM(1), FBL(1), LDHA(2), NCL(2) 820709 9 8 9 5 5 1 1 1 1 0 0.723 1.000 1.000 201 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(2), DAB1(12), FYN(2), LRP8(2), RELN(17), VLDLR(1) 1269003 36 26 36 14 24 2 1 4 5 0 0.374 1.000 1.000 202 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(2), GNA12(1), PRKACG(2), PRKAG1(1), PRKAR2B(1) 920860 7 7 7 8 6 0 0 0 1 0 0.937 1.000 1.000 203 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX3(2), PLA2G1B(1), PLA2G2D(1), PLA2G2F(2), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3) 924438 16 12 16 9 13 0 0 3 0 0 0.518 1.000 1.000 204 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSS(1), NFKB1(3), NOX1(4), RELA(2), XDH(14) 899972 24 21 22 11 18 1 0 5 0 0 0.277 1.000 1.000 205 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(2), IL10(1), IL12A(1), IL15(1), IL16(3), IL1A(1), IL2(1), IL5(1), IL6(1) 898165 12 10 12 8 8 0 1 2 1 0 0.608 1.000 1.000 206 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(4), F2R(2), F2RL3(1), HRAS(1), ITGA1(4), ITGB1(1), MAP2K1(4), MAPK1(3), MAPK3(1), PLA2G4A(2), PLCB1(13), PRKCA(1), PTGS1(3), PTK2(3), RAF1(2), SYK(3), TBXAS1(2) 2220900 50 32 49 18 30 5 1 6 8 0 0.111 1.000 1.000 207 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(3), DLAT(1), DLD(1), FH(1), IDH2(1), IDH3A(1), MDH2(1), OGDH(2), PC(3), PDHA1(1), PDHA2(2), PDHB(1), PDHX(1), PDK1(1), PDK3(1), PDK4(1), PDP2(1), SDHC(1), SUCLG1(1) 2596194 25 19 24 9 17 2 3 1 2 0 0.222 1.000 1.000 208 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(1), IFNB1(2), NFKB1(3), RELA(2) 1010476 9 9 9 9 5 1 0 2 1 0 0.972 1.000 1.000 209 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 MAP2K1(4), MAP2K2(1), MAP2K3(2), MAP3K1(1), MAPK1(3), MAPK3(1), NFKB1(3), PIK3CA(1), RB1(3), RELA(2) 1763310 21 17 21 9 8 3 2 3 5 0 0.573 1.000 1.000 210 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(2), BAX(2), BCL2(1), BIRC2(2), BIRC3(1), CASP3(1), CASP7(3), CASP8(2), CASP9(1), CYCS(1), FAS(2), FASLG(5), GZMB(1), MAP2K4(1), MAP3K1(1), MAP3K14(2), MAPK10(2), MCL1(1), MDM2(1), MYC(2), NFKB1(3), PRF1(3), RELA(2), RIPK1(1), TNFRSF1A(1), TNFRSF1B(2), TNFSF10(2), TRAF1(1) 3321880 49 29 49 11 30 6 2 7 4 0 0.00828 1.000 1.000 211 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(4), CAMP(1), CASP3(1), CERK(1), CREB5(2), DAG1(4), EPHB2(4), FOS(1), GNAQ(1), ITPKB(2), MAP2K4(1), MAP2K7(1), MAPK1(3), MAPK10(2), MAPK8IP2(2), MAPK8IP3(3) 2589233 33 26 33 11 21 0 1 2 9 0 0.152 1.000 1.000 212 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(1), JAK2(1), JAK3(2), PIAS1(1), PIAS3(1), PTPRU(2), REG1A(1) 1242685 9 9 9 7 5 1 0 1 2 0 0.892 1.000 1.000 213 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACO2(3), CLYBL(2), DLD(1), FH(1), IDH1(5), IDH2(1), IDH3A(1), MDH2(1), OGDH(2), OGDHL(9), PC(3), PCK1(4), PCK2(3), SDHC(1), SUCLG1(1) 2736336 38 26 35 10 28 2 3 2 3 0 0.0118 1.000 1.000 214 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(3), DHRS2(2), DHRS3(1), DHRSX(1), HEMK1(1), LCMT1(1), METTL2B(2), PRMT3(2), PRMT8(1) 1377768 14 12 14 8 6 1 0 5 2 0 0.747 1.000 1.000 215 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNB1(2), JAK1(1), PTPRU(2), REG1A(1), STAT1(2), TYK2(3) 1144969 11 10 11 6 8 1 0 1 1 0 0.525 1.000 1.000 216 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(2), BIRC3(1), CASP3(1), CASP8(2), CFLAR(3), MAP2K4(1), MAP3K7(1), NFKB1(3), NFKB2(2), NFKBIL2(2), RALBP1(2), RIPK1(1), TNFAIP3(1), TNFRSF1A(1), TNFRSF1B(2) 2468767 25 19 25 6 15 0 3 5 2 0 0.0961 1.000 1.000 217 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(4), COPS5(1), EP300(4), EPO(1), HIF1A(2), LDHA(2), NOS3(2), VHL(1) 1555454 17 17 17 9 8 2 2 2 3 0 0.662 1.000 1.000 218 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BRAF(3), CAMP(1), CREB5(2), MAPK1(3), RAF1(2), TERF2IP(1) 1023204 12 12 12 6 7 1 0 3 1 0 0.669 1.000 1.000 219 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 DHCR7(5), FDPS(1), GGCX(1), HSD17B7(1), PMVK(1), SQLE(1), TM7SF2(2) 1761167 12 11 12 5 5 4 1 1 1 0 0.422 1.000 1.000 220 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPS7(1), RPL11(1), RPL18(2), RPL27(1), RPL3(1), RPL39(1), RPL7(1), RPS13(1), RPS2(1), RPS20(1), RPS6(1) 2057062 12 12 12 5 4 2 0 4 2 0 0.499 1.000 1.000 221 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), HADHA(1) 1104332 11 11 11 6 7 0 2 2 0 0 0.560 1.000 1.000 222 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(2), DHRS3(1), DHRSX(1), MYST3(4), MYST4(1) 1519450 9 7 9 8 4 1 0 2 2 0 0.969 1.000 1.000 223 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 20 CCR3(4), GNAQ(1), GNAS(6), HRAS(1), LIMK1(1), MAP2K1(4), MAPK1(3), MAPK3(1), MYL2(3), NOX1(4), PLCB1(13), PRKCA(1), PTK2(3), RAF1(2), ROCK2(2) 2057432 49 30 47 18 33 2 0 7 7 0 0.181 1.000 1.000 224 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(11), C5(3), C6(14), C7(11), ICAM1(1), IL1A(1), IL6(1), ITGA4(5), ITGAL(3), ITGB1(1), ITGB2(4), SELP(8), SELPLG(2), VCAM1(5) 2238061 70 34 68 27 48 1 5 6 10 0 0.0539 1.000 1.000 225 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(5), ABCB11(12), ABCB4(2), ABCC1(3), ABCC3(6), GSTP1(1) 1296650 29 23 28 14 20 3 1 2 3 0 0.159 1.000 1.000 226 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), CAT(2), EPX(2), LPO(2), MPO(1), PRDX2(2), PRDX6(2), SHMT2(1), TPO(8) 1081529 21 18 21 10 16 3 1 0 1 0 0.200 1.000 1.000 227 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 CDK4(1), CDKN1A(3), E2F1(1), HRAS(1), MAPK1(3), MAPK3(1), NFKB1(3), PAK1(1), PIK3CA(1), RAC1(3), RAF1(2), RB1(3), RELA(2), TFDP1(1) 1835079 26 20 26 10 11 4 2 3 6 0 0.319 1.000 1.000 228 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 CBS(4), DNMT1(5), DNMT3A(3), DNMT3B(3), MTR(1), TAT(5) 1916032 21 14 21 8 15 2 2 0 2 0 0.230 1.000 1.000 229 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(4), AXIN1(2), BMP10(6), BMP2(1), BMP4(1), BMP5(8), BMP7(1), CHRD(3), CTNNB1(1), FZD1(1), GATA4(1), MAP3K7(1), MEF2C(1), MYL2(3), NKX2-5(1), NPPA(1), NPPB(1), TGFB1(1), TGFB3(1), TGFBR2(3), TGFBR3(3) 3297987 45 28 44 14 33 5 2 1 4 0 0.0724 1.000 1.000 230 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(1), ASL(3), CKM(1), CKMT2(1), CPS1(4), GAMT(1), GATM(1), NAGS(1), OAT(1), OTC(1), PYCR1(1) 1576353 16 15 16 8 10 3 0 1 2 0 0.478 1.000 1.000 231 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(1), CR1(16), CR2(7), FCGR2B(1), HLA-DRA(3), ICAM1(1), ITGAL(3), ITGB2(4), PTPRC(3) 1372646 39 29 39 16 26 4 0 3 6 0 0.283 1.000 1.000 232 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(1), DDX20(2), E2F1(1), ETS1(1), ETS2(3), ETV3(1), FOS(1), HDAC5(2), HRAS(1), NCOR2(8), RBL1(3), RBL2(1), SIN3A(2), SIN3B(5) 2371371 32 25 32 12 17 4 1 5 5 0 0.219 1.000 1.000 233 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), ESR2(3), PDE1A(7), PDE1B(2), PLCB1(13), PLCB2(4), PRL(1), VIP(1) 1005265 32 24 31 15 25 1 0 1 5 0 0.214 1.000 1.000 234 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(6), GNAS(6), HRAS(1), IGF1R(1), ITGB1(1), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), MYC(2), NGFR(3), PDGFRA(7), PPP2CA(1), PTPRR(6), RAF1(2), RPS6KA1(3), SOS1(1) 2994956 49 30 49 18 29 3 4 8 5 0 0.167 1.000 1.000 235 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(2), CAPN1(1), CAPN2(1), CXCR3(1), EGF(4), EGFR(6), HRAS(1), ITGA1(4), ITGB1(1), MAPK1(3), MAPK3(1), MYL2(3), MYLK(11), PRKACG(2), PRKAR2B(1), PTK2(3), TLN1(4) 2954655 49 28 47 18 30 4 4 6 5 0 0.0675 1.000 1.000 236 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(1), CA1(2), CA2(2), CA3(1), CA4(1), CA6(1), CA8(2), CA9(1), CPS1(4), HAL(3) 1717519 18 15 18 9 12 2 0 1 3 0 0.469 1.000 1.000 237 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(3), DNMT1(5), MTNR1A(4), MTNR1B(2), PTGDR(2), PTGER2(1), PTGER4(1), PTGFR(6) 1017956 24 19 24 14 16 2 1 3 2 0 0.279 1.000 1.000 238 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(2), ACADS(2), ACSL1(1), ACSL3(2), CPT1A(2), CPT2(1), DCI(1), HADHA(1), SCP2(1) 1550768 15 15 15 7 10 0 2 1 2 0 0.617 1.000 1.000 239 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(6), EP300(4), LPL(1), NCOA1(2), PPARG(3), RXRA(1) 1697783 17 17 17 7 8 1 1 4 3 0 0.696 1.000 1.000 240 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 MAP3K14(2), NFKB1(3), RELA(2), TNFRSF13B(2), TNFRSF17(1), TNFSF13B(1), TRAF5(2) 1312134 13 12 13 8 6 2 0 4 1 0 0.790 1.000 1.000 241 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CARM1(3), CBS(4), GGT1(1), HEMK1(1), LCMT1(1), METTL2B(2), PAPSS2(1), PRMT3(2), PRMT8(1), SCLY(1), SEPHS1(2), SEPHS2(2) 2290480 21 18 21 8 11 2 0 7 1 0 0.278 1.000 1.000 242 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), GTF2B(3), GTF2E1(1), GTF2F2(1), POLR1A(3), POLR1B(1), POLR2A(4), POLR2B(3), POLR2E(1), POLR2F(1), POLR2J(1), POLR3B(2), POLR3E(1), TAF13(1), TAF6(1), TBP(1) 3203783 27 22 27 8 16 1 1 5 4 0 0.164 1.000 1.000 243 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CDKN1A(3), GNAQ(1), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), PRKCA(1), SYT1(4) 1907504 21 15 20 9 13 3 3 0 2 0 0.336 1.000 1.000 244 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA5(1), PSMB5(1), PSMC3(1), RPN2(1), UBE3A(1) 1187263 5 5 5 6 2 0 0 2 1 0 0.983 1.000 1.000 245 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT7(2), B4GALT4(2), CHST1(1), CHST4(1), CHST6(1), FUT8(1), ST3GAL1(2), ST3GAL4(1) 1136424 11 11 11 7 5 4 0 1 1 0 0.553 1.000 1.000 246 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 HRAS(1), IGF1R(1), IRS1(3), MAP2K1(4), MAPK1(3), MAPK3(1), PIK3CA(1), RAF1(2), SOS1(1) 1735815 17 13 17 7 8 2 1 2 4 0 0.606 1.000 1.000 247 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(6), EP300(4), HDAC3(3), NFKB1(3), RELA(2), RIPK1(1), TNFRSF1A(1), TNFRSF1B(2) 2033808 22 15 22 8 13 2 1 5 1 0 0.395 1.000 1.000 248 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 26 ACAA1(2), ADH1A(2), ADH1C(8), ADH4(2), ADH7(5), ADHFE1(3), AKR1C4(3), AKR1D1(3), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), BAAT(4), CEL(2), CYP7A1(1), HADHB(3), SOAT2(2), SRD5A1(1), SRD5A2(1) 2051515 52 34 50 23 33 4 6 5 4 0 0.199 1.000 1.000 249 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 AKT2(4), AKT3(2), DAG1(4), GNAQ(1), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(2), NFKB1(3), NFKB2(2), NFKBIL2(2), PDK1(1), PHKA2(4), PIK3CB(7), PITX2(2), PLD1(2), PLD2(3) 4087233 53 30 52 16 27 3 4 11 8 0 0.0175 1.000 1.000 250 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(3), ACTG1(1), ARHGEF2(4), CD14(2), CLDN1(1), CTNNB1(1), CTTN(1), FYN(2), HCLS1(2), ITGB1(1), NCK1(1), NCK2(1), NCL(2), OCLN(1), PRKCA(1), ROCK2(2), TLR5(4), TUBA3C(9), TUBA3D(5), TUBA4A(1), TUBA8(2), TUBAL3(6), TUBB2A(1), TUBB4Q(4), TUBB6(2), TUBB8(5), WAS(1), WASL(2) 4624350 68 41 65 23 43 6 3 7 9 0 0.0259 1.000 1.000 251 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(3), ACTG1(1), ARHGEF2(4), CD14(2), CLDN1(1), CTNNB1(1), CTTN(1), FYN(2), HCLS1(2), ITGB1(1), NCK1(1), NCK2(1), NCL(2), OCLN(1), PRKCA(1), ROCK2(2), TLR5(4), TUBA3C(9), TUBA3D(5), TUBA4A(1), TUBA8(2), TUBAL3(6), TUBB2A(1), TUBB4Q(4), TUBB6(2), TUBB8(5), WAS(1), WASL(2) 4624350 68 41 65 23 43 6 3 7 9 0 0.0259 1.000 1.000 252 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 28 B4GALT5(2), C1GALT1(2), C1GALT1C1(1), GALNT1(2), GALNT11(1), GALNT12(3), GALNT13(11), GALNT14(5), GALNT2(4), GALNT3(1), GALNT4(2), GALNT5(2), GALNT6(2), GALNT9(2), GALNTL1(2), GALNTL2(2), GALNTL4(1), GALNTL5(3), GCNT1(1), OGT(6), ST3GAL1(2) 2707247 57 34 55 20 33 2 1 13 8 0 0.170 1.000 1.000 253 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 10 C1R(3), C1S(1), C2(3), C3(11), C5(3), C6(14), C7(11), C8A(9) 1465324 55 29 52 24 40 2 2 3 8 0 0.142 1.000 1.000 254 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 HRAS(1), NTRK1(2), PIK3CA(1), PRKCA(1), SOS1(1) 1420129 6 5 6 6 4 1 0 0 1 0 0.966 1.000 1.000 255 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT2(4), AKT3(2), BRAF(3), EIF4B(1), FIGF(1), HIF1A(2), IGF1(2), MAPK1(3), MAPK3(1), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PRKAA2(5), RICTOR(5), RPS6(1), RPS6KA1(3), RPS6KA3(1), RPS6KA6(4), RPS6KB1(1), RPS6KB2(2), STK11(1), TSC1(1), TSC2(6), ULK1(2), ULK2(1), VEGFA(3), VEGFC(3) 4790884 78 40 77 24 43 8 3 16 7 1 0.0271 1.000 1.000 256 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(2), POLE(1), POLG(1), POLL(1), POLQ(5) 1524148 10 10 10 7 5 1 0 3 1 0 0.808 1.000 1.000 257 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(5), ITGAV(3), ITGB3(3), MAPK1(3), MAPK3(1), PDGFRA(7), PIK3CA(1), PLCB1(13), PRKCA(1), PTK2(3), RAC1(3), SMPD1(1) 2511644 44 28 43 18 31 2 0 5 6 0 0.158 1.000 1.000 258 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA5(1), PSMB5(1), PSMC3(1), PSMD1(3), PSMD13(1), PSMD2(2) 1475306 9 8 9 6 3 1 0 4 1 0 0.910 1.000 1.000 259 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ACTR3(2), ARHGAP1(1), ARHGAP5(3), ARHGAP6(1), ARHGEF11(3), ARHGEF5(4), ARPC3(1), DIAPH1(2), GSN(3), LIMK1(1), MYL2(3), MYLK(11), OPHN1(1), PIP5K1A(2), PIP5K1B(6), TLN1(4), VCL(3) 4090726 53 31 51 17 38 5 3 5 2 0 0.0170 1.000 1.000 260 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA1(1), GLB1(1), HEXA(1), HEXB(1), LCT(6), NEU2(2), NEU3(1), NEU4(4) 1503807 17 15 17 9 14 1 0 1 1 0 0.519 1.000 1.000 261 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT2(4), AKT3(2), ANKRD6(1), APC(4), AXIN1(2), CER1(2), CSNK1A1(1), CTNNB1(1), DACT1(2), DKK2(4), DKK3(1), DKK4(1), FSTL1(1), LRP1(10), NKD1(2), NKD2(1), PTPRA(2), SENP2(3), SFRP1(1), TSHB(1), WIF1(2) 3643497 48 28 48 17 28 6 1 6 7 0 0.112 1.000 1.000 262 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 GCK(3), GNE(2), HEXA(1), HEXB(1), HK1(1), HK2(1), HK3(2), UAP1(1) 1549366 12 12 12 8 7 3 0 1 1 0 0.726 1.000 1.000 263 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 CASP9(1), HRAS(1), MAP2K1(4), MAPK3(1), NFKB1(3), PIK3CA(1), RAC1(3), RAF1(2), RALBP1(2), RALGDS(3), RELA(2) 1719466 23 18 23 10 14 2 0 5 2 0 0.531 1.000 1.000 264 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3D(1), CD3G(1), CXCR3(1), ETV5(3), IL12A(1), IL12RB1(3), IL12RB2(1), IL18R1(8), JAK2(1), STAT4(1), TYK2(3) 1686174 24 17 24 10 19 3 0 1 1 0 0.312 1.000 1.000 265 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(4), ATR(4), BRCA1(3), BRCA2(3), FANCA(2), FANCC(2), FANCD2(4), FANCF(1), FANCG(2), MRE11A(1), RAD1(1), RAD17(2), RAD9A(2) 3948367 31 22 31 9 22 0 0 5 4 0 0.239 1.000 1.000 266 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(7), ACACB(7), FASN(5), MCAT(1), OLAH(4) 1447011 24 18 23 12 11 3 2 3 5 0 0.478 1.000 1.000 267 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(3), CASP3(1), CASP7(3), CASP8(2), CFLAR(3), DAXX(3), DFFB(1), FAF1(2), LMNB1(1), LMNB2(1), MAP2K4(1), MAP3K1(1), MAP3K7(1), PAK1(1), PRKDC(3), PTPN13(6), RB1(3), RIPK2(1), SPTAN1(1) 3749809 38 26 38 12 15 5 3 7 8 0 0.237 1.000 1.000 268 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(3), GNA12(1), GNAQ(1), MYL2(3), MYLK(11), PLCB1(13), PRKCA(1) 1896266 33 23 30 13 26 2 1 2 2 0 0.196 1.000 1.000 269 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(2), CALM1(1), CAPN2(1), EP300(4), MEF2D(2), NFATC1(2), NFATC2(1), PRKCA(1), SYT1(4) 2236042 18 14 17 7 12 2 3 1 0 0 0.302 1.000 1.000 270 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(3), G6PD(1), GCLC(2), GGT1(1), GPX5(3), GPX6(6), GSS(1), GSTA1(1), GSTA2(1), GSTA5(1), GSTK1(1), GSTM1(1), GSTM4(1), GSTM5(3), GSTP1(1), GSTT1(1), IDH1(5), IDH2(1) 1994055 34 23 31 17 24 1 3 3 3 0 0.201 1.000 1.000 271 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 IL2(1), MAP3K1(1), MAP3K5(3), NFKB1(3), RELA(2), TNFRSF9(1) 1746739 11 9 11 9 6 1 0 3 1 0 0.947 1.000 1.000 272 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(4), ATR(4), BRCA1(3), CDC25A(3), CDC25B(3), CDC25C(2), CDC34(2), CDKN1A(3), EP300(4), MDM2(1), MYT1(7), PRKDC(3), RPS6KA1(3) 3763240 42 31 42 13 23 7 0 6 6 0 0.162 1.000 1.000 273 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 80 ABL1(3), ATM(4), BUB1(2), CCNA1(3), CCNB3(7), CCND2(1), CCNE2(3), CCNH(2), CDC14A(2), CDC25A(3), CDC25B(3), CDC25C(2), CDC6(1), CDK4(1), CDKN1A(3), DTX4(1), E2F1(1), E2F2(2), E2F5(1), EP300(4), ESPL1(2), HDAC3(3), HDAC4(2), HDAC5(2), HDAC8(2), MAD1L1(1), MAD2L1(1), MCM2(2), MCM3(3), MCM4(1), MCM5(1), MDM2(1), MPEG1(1), MPL(2), ORC1L(1), ORC2L(1), ORC3L(1), ORC4L(2), ORC6L(1), PLK1(2), PRKDC(3), PTPRA(2), PTTG2(2), RB1(3), RBL1(3), SKP2(1), TBC1D8(2), TFDP1(1), TGFB1(1) 9872194 99 50 99 25 58 12 4 15 10 0 0.000556 1.000 1.000 274 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT2(4), AKT3(2), BCL2(1), IL4R(6), IRS1(3), IRS2(1), JAK1(1), JAK3(2), MAP4K1(2), MAPK1(3), MAPK3(1), PDK1(1), PIK3CA(1), PIK3CD(1), PPP1R13B(2), RAF1(2), SOS1(1), SOS2(2), STAT6(1) 3339432 37 20 37 13 19 6 2 5 5 0 0.189 1.000 1.000 275 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 43 ACTR2(2), ACTR3(2), AKT2(4), AKT3(2), ARHGAP1(1), ARHGEF11(3), BTK(4), GDI1(1), GDI2(1), INPPL1(4), ITPR1(4), ITPR2(8), ITPR3(2), LIMK1(1), MYLK(11), MYLK2(2), PAK1(1), PAK6(2), PDK1(1), PIK3CA(1), PIK3CD(1), PIK3CG(7), PITX2(2), PPP1R13B(2), PTEN(4), RACGAP1(2), ROCK2(2), SAG(2), WASF1(1), WASL(2) 6233354 82 38 81 24 41 8 3 16 14 0 0.00981 1.000 1.000 276 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(2), BAX(2), BCL2(1), BCL2L11(4), BIRC2(2), BIRC3(1), BNIP3L(1), CASP3(1), CASP7(3), CASP8(2), CASP9(1), CYCS(1), DFFB(1), FAS(2), FASLG(5), GZMB(1), IRF2(1), IRF3(1), IRF5(1), IRF6(3), IRF7(3), MAP2K4(1), MAP3K1(1), MAPK10(2), MDM2(1), MYC(2), NFKB1(3), PLEKHG5(4), PRF1(3), RELA(2), RIPK1(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(4), TNFRSF25(1), TNFSF10(2), TP73(2), TRAF1(1) 5134315 72 37 72 23 48 6 4 8 6 0 0.0234 1.000 1.000 277 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(2), BAX(2), BCL2(1), BCL2A1(1), CASP3(1), CASP7(3), CASP8(2), CASP9(1), CD40(2), CRADD(1), CYCS(1), DAXX(3), DFFB(1), FAS(2), FASLG(5), IKBKE(4), MCL1(1), NFKB1(3), NGFR(3), NR3C1(2), NTRK1(2), PTPN13(6), RIPK1(1), SFRS2IP(1), TNFRSF1A(1), TNFRSF1B(2), TRAF1(1) 3953653 55 31 55 16 33 7 1 8 6 0 0.0408 1.000 1.000 278 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(2), ACTN1(1), ACTN2(3), ACTN3(2), CAPN1(1), ITGA1(4), ITGB1(1), ITGB3(3), PTK2(3), RAC1(3), SPTAN1(1), TLN1(4) 2566859 28 23 28 13 14 2 3 4 5 0 0.244 1.000 1.000 279 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(1), APAF1(2), ARHGDIB(3), BCL2(1), BIRC2(2), BIRC3(1), CASP3(1), CASP7(3), CASP8(2), CASP9(1), CFLAR(3), CRADD(1), CYCS(1), DAXX(3), DFFB(1), GSN(3), LMNB1(1), LMNB2(1), MAP2K7(1), MAP3K1(1), MAP3K14(2), MAP3K5(3), MDM2(1), NFKB1(3), NUMA1(4), PRKCD(1), PRKDC(3), PTK2(3), RASA1(3), RB1(3), RELA(2), RIPK1(1), SPTAN1(1), TNFRSF1A(1), TNFRSF1B(2), TRAF1(1) 6313149 67 34 67 20 26 11 5 14 11 0 0.0510 1.000 1.000 280 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(1), GTF2A1L(3), GTF2B(3), GTF2E1(1), GTF2F1(1), GTF2F2(1), GTF2IRD1(2), TAF1(4), TAF13(1), TAF1L(14), TAF2(2), TAF4B(1), TAF5L(1), TAF6(1), TAF7L(2) 3297460 38 25 37 14 25 3 1 5 4 0 0.232 1.000 1.000 281 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(17), COL4A2(5), COL4A3(6), COL4A4(20), COL4A5(13), COL4A6(10), SLC23A1(1), SLC2A1(1), SLC2A3(1) 2272180 74 39 74 19 55 5 3 8 3 0 0.229 1.000 1.000 282 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 APC(4), BRAF(3), CAMP(1), DAG1(4), EGFR(6), GNA11(2), GNAQ(1), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(2), KCNJ3(4), KCNJ5(2), KCNJ9(2), MAPK1(3), MAPK10(2), PHKA2(4), PIK3CA(1), PIK3CD(1), PITX2(2), RAF1(2) 4834509 60 29 60 20 36 2 4 8 10 0 0.0481 1.000 1.000 283 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2B(2), CAMK2D(1), CAMK2G(1), DAG1(4), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(2), NFAT5(2), PDE6A(3), PDE6B(4), PDE6C(4), PDE6D(1), PDE6G(1), SLC6A13(7), TF(3) 3252132 49 28 49 21 34 0 1 6 8 0 0.0805 1.000 1.000 284 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(3), DIAPH1(2), FYN(2), GSN(3), HRAS(1), ITGA1(4), ITGB1(1), MAP2K1(4), MAPK1(3), MAPK3(1), MYL2(3), MYLK(11), PIK3CA(1), PTK2(3), RAF1(2), TLN1(4) 3399904 48 30 46 18 28 5 2 7 6 0 0.201 1.000 1.000 285 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(3), CARM1(3), CREBBP(6), EP300(4), ESR1(1), GRIP1(1), GTF2A1(1), GTF2E1(1), GTF2F1(1), HDAC3(3), HDAC4(2), HDAC5(2), MEF2C(1), NCOR2(8), NRIP1(1), PELP1(2), POLR2A(4), TBP(1) 4129791 45 30 45 16 26 4 3 8 4 0 0.193 1.000 1.000 286 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 41 ATF1(1), BRAF(3), CAMP(1), CREB5(2), CREBBP(6), DAG1(4), EGR1(2), EGR2(1), EGR4(3), FRS2(1), GNAQ(1), MAP1B(5), MAP2K4(1), MAP2K7(1), MAPK1(3), MAPK10(2), MAPK3(1), MAPK8IP2(2), MAPK8IP3(3), NTRK1(2), PIK3CA(1), PIK3CD(1), PTPN11(1), RPS6KA3(1), TERF2IP(1), TH(1) 4433818 51 30 51 18 38 3 2 4 4 0 0.0687 1.000 1.000 287 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 61 AKT2(4), AKT3(2), CREB5(2), ERBB4(12), F2RL2(1), IGF1(2), INPPL1(4), IRS1(3), IRS2(1), IRS4(2), MET(6), MYC(2), PAK1(1), PAK6(2), PARD3(3), PDK1(1), PIK3CA(1), PIK3CD(1), PPP1R13B(2), PREX1(1), PTEN(4), PTK2(3), PTPN1(3), RPS6KA1(3), RPS6KA3(1), RPS6KB1(1), SLC2A4(1), SOS1(1), SOS2(2), TSC1(1), TSC2(6) 6856683 79 38 79 26 38 10 5 9 16 1 0.0294 1.000 1.000 288 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 DAXX(3), DDIT3(1), HMGN1(1), HRAS(1), MAP2K4(1), MAP3K1(1), MAP3K5(3), MAP3K7(1), MAP3K9(6), MAPKAPK2(2), MEF2A(2), MEF2B(1), MEF2C(1), MEF2D(2), MYC(2), PLA2G4A(2), RAC1(3), RIPK1(1), STAT1(2), TGFB1(1), TGFB3(1) 3310143 38 24 38 12 28 2 0 5 3 0 0.177 1.000 1.000 289 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), ABO(1), B3GALT1(5), B3GALT5(1), B3GNT3(1), B3GNT4(1), B4GALT4(2), FUT2(2), FUT3(1), FUT4(2), FUT7(2), FUT9(6), PIGB(2), PIGF(1), PIGG(3), PIGH(1), PIGK(3), PIGO(3), PIGQ(1), PIGT(1), PIGU(2), PIGV(2), PIGZ(1), ST3GAL1(2), ST3GAL4(1), ST3GAL5(2), ST3GAL6(1), ST6GALNAC3(2), ST6GALNAC4(1), ST8SIA5(3) 4411433 57 36 56 23 33 7 0 10 7 0 0.0868 1.000 1.000 290 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(2), ABAT(4), AGXT(1), AGXT2(7), ASL(3), ASNS(1), ASPA(3), CAD(3), CRAT(2), DARS(4), GAD1(3), GAD2(1), GOT2(3), PC(3) 2385723 40 25 39 19 29 3 4 2 2 0 0.195 1.000 1.000 291 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CALM1(1), CAMK1G(3), FPR1(5), HRAS(1), MAP2K1(4), MAP2K2(1), MAP2K3(2), MAP3K1(1), MAPK1(3), MAPK3(1), NCF2(2), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), NFKB1(3), PAK1(1), PLCB1(13), RAC1(3), RAF1(2), RELA(2), SYT1(4) 3241509 63 33 61 25 39 4 4 7 9 0 0.178 1.000 1.000 292 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 DLD(1), DUSP10(2), DUSP8(1), GCK(3), IL1R1(5), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K11(3), MAP3K13(1), MAP3K4(3), MAP3K5(3), MAP3K7(1), MAP3K9(6), MAPK10(2), MAPK7(2), NFATC3(1), PAPPA(20), ZAK(3) 4510850 60 34 59 19 44 5 2 5 4 0 0.0638 1.000 1.000 293 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), APC(4), CAMP(1), DAG1(4), EPHB2(4), GNAQ(1), ITPR1(4), ITPR2(8), ITPR3(2), KCNJ3(4), KCNJ5(2), KCNJ9(2), MAPK1(3), PITX2(2), RAC1(3), RYR1(15) 4149794 60 34 60 28 40 1 4 6 9 0 0.142 1.000 1.000 294 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 134 ACTG1(1), CHAD(2), COL11A1(16), COL11A2(8), COL17A1(6), COL1A1(9), COL1A2(7), COL2A1(9), COL3A1(18), COL4A1(17), COL4A2(5), COL4A4(20), COL4A6(10), COL5A1(15), COL5A2(10), COL5A3(15), COL6A1(2), COL6A2(3), COL6A3(15), COL6A6(13), DES(2), DSC1(10), DSG1(16), DSG2(6), DSG3(11), DSG4(13), FN1(5), GJA1(2), GJA10(4), GJA4(2), GJA5(1), GJA8(3), GJB1(1), GJB3(1), GJB5(1), GJB6(3), GJD2(1), IBSP(1), ITGA6(2), ITGB4(5), KRT1(4), KRT10(4), KRT12(1), KRT13(4), KRT14(1), KRT15(3), KRT16(5), KRT17(2), KRT2(3), KRT20(2), KRT23(2), KRT24(3), KRT25(4), KRT27(1), KRT28(1), KRT3(3), KRT31(2), KRT32(2), KRT33A(2), KRT33B(1), KRT34(1), KRT35(3), KRT36(4), KRT37(2), KRT38(2), KRT39(2), KRT4(4), KRT40(1), KRT5(4), KRT6A(4), KRT6B(3), KRT6C(2), KRT7(2), KRT71(2), KRT72(1), KRT73(4), KRT74(2), KRT75(1), KRT76(2), KRT77(3), KRT78(8), KRT8(1), KRT81(1), KRT82(1), KRT83(4), KRT84(5), KRT85(2), KRT9(6), LAMA1(8), LAMA2(18), LAMA3(13), LAMA4(4), LAMA5(4), LAMB1(1), LAMB2(5), LAMB3(10), LAMB4(4), LAMC1(2), LAMC2(7), LAMC3(2), LMNB1(1), LMNB2(1), NES(4), RELN(17), SPP1(3), THBS1(3), THBS2(2), THBS3(2), THBS4(2), TNC(2), TNN(12), TNR(21), TNXB(29), VIM(1), VTN(1), VWF(9) 22438556 606 60 601 249 437 40 15 57 57 0 0.000607 1.000 1.000 295 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(5), ADCY2(5), ADCY4(1), ADCY7(2), ADCY8(8), ADCY9(1), ADORA2A(1), ADORA2B(1), ADRA1A(1), ADRB1(1), ADRB2(1), AGTR1(4), ATP2A1(1), ATP2A2(2), ATP2A3(3), ATP2B1(1), ATP2B2(5), ATP2B3(1), ATP2B4(1), AVPR1B(3), BDKRB2(3), CACNA1A(7), CACNA1B(4), CACNA1C(13), CACNA1D(10), CACNA1E(24), CACNA1F(10), CACNA1G(6), CACNA1H(9), CACNA1I(10), CACNA1S(10), CALM1(1), CALML3(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CAMK4(1), CCKAR(4), CCKBR(5), CHP(2), CHRM2(6), CHRM3(3), CHRNA7(1), CYSLTR1(2), DRD1(3), EDNRA(2), EDNRB(1), EGFR(6), ERBB2(3), ERBB3(1), ERBB4(12), F2R(2), GNA11(2), GNA14(3), GNAQ(1), GNAS(6), GRIN1(2), GRIN2A(15), GRIN2C(1), GRIN2D(3), GRM1(3), GRM5(3), GRPR(1), HRH1(3), HRH2(2), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(1), HTR5A(7), HTR7(2), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(2), LHCGR(7), MYLK(11), MYLK2(2), NOS1(11), NOS3(2), OXTR(2), P2RX1(1), P2RX3(2), P2RX5(1), P2RX7(2), PDE1A(7), PDE1B(2), PDE1C(11), PDGFRA(7), PDGFRB(3), PHKA1(3), PHKA2(4), PHKB(1), PLCB1(13), PLCB2(4), PLCB4(13), PLCD3(3), PLCE1(11), PLCG2(6), PLCZ1(6), PPP3R2(2), PRKACA(1), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(1), PTGER3(2), PTGFR(6), RYR1(15), RYR2(20), RYR3(16), SLC25A6(1), SLC8A1(8), SLC8A2(3), SLC8A3(12), SPHK2(2), TACR1(1), TACR2(2), TACR3(4), TNNC1(2), TRHR(5), TRPC1(1), VDAC2(1) 24235662 540 60 530 334 378 38 22 51 51 0 0.0778 1.000 1.000 296 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 231 ADORA1(2), ADORA2A(1), ADORA2B(1), ADORA3(2), ADRA1A(1), ADRA2B(3), ADRB1(1), ADRB2(1), AGTR1(4), AGTR2(2), AVPR1B(3), BDKRB2(3), C3AR1(3), C5AR1(2), CALCR(4), CALCRL(4), CCKAR(4), CCKBR(5), CGA(1), CHRM2(6), CHRM3(3), CHRM4(2), CNR1(3), CRHR1(2), CYSLTR1(2), DRD1(3), DRD2(2), DRD3(3), DRD5(3), EDNRA(2), EDNRB(1), F2(4), F2R(2), F2RL2(1), F2RL3(1), FPR1(5), FSHB(2), FSHR(3), GABBR1(1), GABBR2(3), GABRA1(2), GABRA2(1), GABRA3(8), GABRA4(1), GABRA6(3), GABRB1(3), GABRB2(1), GABRB3(5), GABRD(1), GABRE(3), GABRG1(9), GABRG2(3), GABRG3(2), GABRP(3), GABRQ(3), GABRR1(1), GALR1(2), GH2(1), GHR(4), GHRHR(1), GLP1R(3), GLP2R(4), GLRA1(2), GLRA3(3), GPR156(3), GPR35(1), GPR50(5), GPR63(3), GPR83(1), GRIA1(7), GRIA2(11), GRIA3(3), GRIA4(4), GRID1(3), GRID2(11), GRIK1(4), GRIK3(3), GRIK4(2), GRIK5(2), GRIN1(2), GRIN2A(15), GRIN2B(11), GRIN2C(1), GRIN2D(3), GRIN3A(8), GRIN3B(1), GRM1(3), GRM2(2), GRM3(13), GRM4(3), GRM5(3), GRM6(5), GRM7(10), GRM8(4), GRPR(1), GZMA(1), HRH1(3), HRH2(2), HRH4(1), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(1), HTR1F(2), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(1), HTR5A(7), HTR7(2), LEPR(7), LHCGR(7), LTB4R(1), MC2R(1), MC3R(1), MC4R(1), MC5R(1), MCHR1(1), MCHR2(8), MTNR1A(4), MTNR1B(2), NMBR(2), NMUR2(1), NPBWR2(5), NPFFR2(2), NPY1R(5), NPY2R(3), NPY5R(6), NR3C1(2), NTSR2(1), OPRK1(3), OPRM1(1), OXTR(2), P2RX1(1), P2RX3(2), P2RX5(1), P2RX7(2), P2RY10(1), P2RY13(2), P2RY14(3), P2RY2(2), P2RY8(3), PARD3(3), PPYR1(1), PRL(1), PRLR(5), PRSS1(9), PRSS3(2), PTGDR(2), PTGER2(1), PTGER3(2), PTGER4(1), PTGFR(6), PTH2R(3), RXFP1(6), RXFP2(6), SCTR(1), SSTR2(2), SSTR4(3), SSTR5(1), TAAR1(2), TAAR2(1), TAAR5(3), TAAR6(3), TAAR8(2), TAAR9(1), TACR1(1), TACR2(2), TACR3(4), THRA(1), THRB(4), TRHR(5), TSHB(1), TSHR(1), UTS2R(1), VIPR1(1), VIPR2(2) 19596038 524 60 515 367 366 35 20 51 52 0 0.292 1.000 1.000 297 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 191 ACTG1(1), ACTN1(1), ACTN2(3), ACTN3(2), ACTN4(3), AKT2(4), AKT3(2), ARHGAP5(3), BCAR1(1), BCL2(1), BIRC2(2), BIRC3(1), BRAF(3), CAPN2(1), CCND2(1), CHAD(2), COL11A1(16), COL11A2(8), COL1A1(9), COL1A2(7), COL2A1(9), COL3A1(18), COL4A1(17), COL4A2(5), COL4A4(20), COL4A6(10), COL5A1(15), COL5A2(10), COL5A3(15), COL6A1(2), COL6A2(3), COL6A3(15), COL6A6(13), CTNNB1(1), DIAPH1(2), DOCK1(5), EGF(4), EGFR(6), ERBB2(3), FIGF(1), FLNA(2), FLNB(7), FLNC(10), FLT1(9), FN1(5), FYN(2), GRLF1(1), HGF(7), HRAS(1), IBSP(1), IGF1(2), IGF1R(1), ITGA1(4), ITGA10(3), ITGA11(4), ITGA2(4), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(5), ITGA6(2), ITGA7(6), ITGA8(9), ITGA9(2), ITGAV(3), ITGB1(1), ITGB3(3), ITGB4(5), ITGB5(2), ITGB6(3), ITGB7(2), ITGB8(3), KDR(10), LAMA1(8), LAMA2(18), LAMA3(13), LAMA4(4), LAMA5(4), LAMB1(1), LAMB2(5), LAMB3(10), LAMB4(4), LAMC1(2), LAMC2(7), LAMC3(2), MAP2K1(4), MAPK1(3), MAPK10(2), MAPK3(1), MET(6), MYL2(3), MYL7(1), MYLK(11), MYLK2(2), MYLPF(1), PAK1(1), PAK6(2), PARVB(2), PARVG(1), PDGFB(2), PDGFC(2), PDGFD(1), PDGFRA(7), PDGFRB(3), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PIP5K1C(2), PPP1CB(1), PRKCA(1), PRKCG(4), PTEN(4), PTK2(3), RAC1(3), RAF1(2), RAP1A(1), RAP1B(1), RAPGEF1(4), RELN(17), ROCK2(2), SHC2(2), SHC3(4), SHC4(1), SOS1(1), SOS2(2), SPP1(3), THBS1(3), THBS2(2), THBS3(2), THBS4(2), TLN1(4), TLN2(6), TNC(2), TNN(12), TNR(21), TNXB(29), VASP(1), VAV1(3), VAV2(2), VAV3(4), VCL(3), VEGFA(3), VEGFC(3), VTN(1), VWF(9), ZYX(1) 33669177 698 59 689 267 484 45 20 77 72 0 3.20e-05 1.000 1.000 298 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(5), CD36(1), CHAD(2), COL11A1(16), COL11A2(8), COL1A1(9), COL1A2(7), COL2A1(9), COL3A1(18), COL4A1(17), COL4A2(5), COL4A4(20), COL4A6(10), COL5A1(15), COL5A2(10), COL5A3(15), COL6A1(2), COL6A2(3), COL6A3(15), COL6A6(13), DAG1(4), FN1(5), FNDC1(9), FNDC3A(4), FNDC4(1), FNDC5(1), GP5(3), GP6(1), HMMR(1), HSPG2(4), IBSP(1), ITGA1(4), ITGA10(3), ITGA11(4), ITGA2(4), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(5), ITGA6(2), ITGA7(6), ITGA8(9), ITGA9(2), ITGAV(3), ITGB1(1), ITGB3(3), ITGB4(5), ITGB5(2), ITGB6(3), ITGB7(2), ITGB8(3), LAMA1(8), LAMA2(18), LAMA3(13), LAMA4(4), LAMA5(4), LAMB1(1), LAMB2(5), LAMB3(10), LAMB4(4), LAMC1(2), LAMC2(7), LAMC3(2), RELN(17), SDC1(2), SDC2(1), SPP1(3), SV2A(5), SV2B(6), SV2C(2), THBS1(3), THBS2(2), THBS3(2), THBS4(2), TNC(2), TNN(12), TNR(21), TNXB(29), VTN(1), VWF(9) 20446731 502 59 499 187 362 27 14 49 50 0 0.00149 1.000 1.000 299 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 65 A2M(5), BDKRB2(3), C1R(3), C1S(1), C2(3), C3(11), C3AR1(3), C4BPA(8), C4BPB(3), C5(3), C5AR1(2), C6(14), C7(11), C8A(9), C8B(9), CD59(1), CFB(12), CFH(13), CPB2(1), CR1(16), CR2(7), F10(2), F11(3), F13A1(6), F13B(6), F2(4), F2R(2), F5(7), F7(3), F8(6), F9(4), FGA(8), FGG(2), KLKB1(6), KNG1(3), MASP1(4), MASP2(3), MBL2(2), PLAT(3), PLAUR(1), PLG(8), PROS1(2), SERPINA1(2), SERPINA5(2), SERPINC1(1), SERPIND1(1), SERPINF2(3), SERPING1(3), TFPI(4), THBD(1), VWF(9) 8000288 249 59 246 107 170 20 13 21 25 0 0.0424 1.000 1.000 300 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 201 ACTN1(1), ACTN2(3), ACTN3(2), ACTN4(3), APC(4), APC2(2), ARAF(2), ARHGEF12(4), ARHGEF4(2), ARHGEF6(3), ARHGEF7(2), ARPC3(1), BCAR1(1), BDKRB2(3), BRAF(3), CD14(2), CHRM2(6), CHRM3(3), CHRM4(2), CYFIP1(3), CYFIP2(7), DIAPH1(2), DIAPH2(1), DIAPH3(4), DOCK1(5), EGF(4), EGFR(6), F2(4), F2R(2), FGD1(1), FGD3(2), FGF10(1), FGF12(1), FGF13(2), FGF14(1), FGF16(3), FGF19(1), FGF2(2), FGF23(2), FGF5(1), FGF6(1), FGF7(1), FGF9(1), FGFR1(4), FGFR2(10), FGFR3(2), FGFR4(5), FN1(5), GIT1(2), GNA12(1), GRLF1(1), GSN(3), HRAS(1), IQGAP1(1), IQGAP2(6), IQGAP3(3), ITGA1(4), ITGA10(3), ITGA11(4), ITGA2(4), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(5), ITGA6(2), ITGA7(6), ITGA8(9), ITGA9(2), ITGAD(4), ITGAE(2), ITGAL(3), ITGAM(3), ITGAV(3), ITGAX(1), ITGB1(1), ITGB2(4), ITGB3(3), ITGB4(5), ITGB5(2), ITGB6(3), ITGB7(2), ITGB8(3), LIMK1(1), LIMK2(4), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), MYH10(4), MYH14(3), MYH9(7), MYL2(3), MYL7(1), MYLK(11), MYLK2(2), MYLPF(1), NCKAP1(2), NCKAP1L(6), PAK1(1), PAK6(2), PDGFB(2), PDGFRA(7), PDGFRB(3), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PIP4K2B(1), PIP5K1A(2), PIP5K1B(6), PIP5K1C(2), PPP1CB(1), PTK2(3), RAC1(3), RAF1(2), ROCK2(2), RRAS(1), SCIN(2), SLC9A1(2), SOS1(1), SOS2(2), SSH1(3), SSH2(2), SSH3(1), TIAM1(5), TIAM2(7), TMSL3(1), VAV1(3), VAV2(2), VAV3(4), VCL(3), WAS(1), WASF1(1), WASL(2) 24852220 393 59 387 201 259 26 13 56 39 0 0.161 1.000 1.000 301 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 245 ACVR1B(1), ACVR1C(3), AKT2(4), AKT3(2), ARRB1(2), ARRB2(2), ATF4(2), BRAF(3), CACNA1A(7), CACNA1B(4), CACNA1C(13), CACNA1D(10), CACNA1E(24), CACNA1F(10), CACNA1G(6), CACNA1H(9), CACNA1I(10), CACNA1S(10), CACNA2D1(2), CACNA2D2(4), CACNA2D3(9), CACNA2D4(4), CACNB2(2), CACNB4(3), CACNG1(1), CACNG2(2), CACNG3(7), CACNG4(2), CACNG5(1), CACNG7(1), CACNG8(1), CASP3(1), CD14(2), CDC25B(3), CHP(2), DAXX(3), DDIT3(1), DUSP10(2), DUSP2(1), DUSP5(1), DUSP8(1), DUSP9(1), ECSIT(1), EGF(4), EGFR(6), ELK4(2), FAS(2), FASLG(5), FGF10(1), FGF12(1), FGF13(2), FGF14(1), FGF16(3), FGF19(1), FGF2(2), FGF23(2), FGF5(1), FGF6(1), FGF7(1), FGF9(1), FGFR1(4), FGFR2(10), FGFR3(2), FGFR4(5), FLNA(2), FLNB(7), FLNC(10), FOS(1), GADD45B(2), GNA12(1), HRAS(1), IL1A(1), IL1B(2), IL1R1(5), IL1R2(2), MAP2K1(4), MAP2K2(1), MAP2K3(2), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K13(1), MAP3K14(2), MAP3K4(3), MAP3K5(3), MAP3K6(1), MAP3K7(1), MAP4K1(2), MAP4K2(1), MAP4K3(3), MAP4K4(3), MAPK1(3), MAPK10(2), MAPK3(1), MAPK7(2), MAPK8IP2(2), MAPK8IP3(3), MAPKAPK2(2), MAPKAPK3(1), MAPT(3), MEF2C(1), MYC(2), NF1(7), NFATC2(1), NFATC4(7), NFKB1(3), NFKB2(2), NLK(3), NTRK1(2), NTRK2(2), PAK1(1), PDGFB(2), PDGFRA(7), PDGFRB(3), PLA2G1B(1), PLA2G2D(1), PLA2G2F(2), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), PPM1A(2), PPP3R2(2), PPP5C(1), PRKACA(1), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(1), PTPN5(3), PTPRR(6), RAC1(3), RAF1(2), RAP1A(1), RAP1B(1), RAPGEF2(1), RASA1(3), RASGRF1(6), RASGRF2(3), RASGRP1(2), RASGRP2(1), RASGRP3(4), RASGRP4(1), RPS6KA1(3), RPS6KA3(1), RPS6KA6(4), RRAS(1), SOS1(1), SOS2(2), SRF(1), STMN1(1), TAOK2(5), TGFB1(1), TGFB3(1), TGFBR2(3), TNFRSF1A(1), ZAK(3) 25606815 456 58 451 235 300 47 17 50 42 0 0.0596 1.000 1.000 302 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 124 ABL1(3), ABLIM1(4), ABLIM2(1), ABLIM3(1), ARHGEF12(4), CDK5(2), CHP(2), CXCL12(1), CXCR4(1), DCC(20), DPYSL5(2), EPHA1(2), EPHA2(3), EPHA3(6), EPHA4(6), EPHA5(2), EPHA6(15), EPHA7(14), EPHA8(4), EPHB1(7), EPHB2(4), EPHB3(4), EPHB4(4), EPHB6(5), FES(1), FYN(2), GNAI3(1), HRAS(1), ITGB1(1), LIMK1(1), LIMK2(4), MAPK1(3), MAPK3(1), MET(6), NCK1(1), NCK2(1), NFAT5(2), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), NGEF(4), NRP1(5), NTN4(1), NTNG1(2), PAK1(1), PAK6(2), PLXNA1(3), PLXNA2(1), PLXNA3(3), PLXNB1(6), PLXNB2(2), PLXNB3(2), PLXNC1(3), PPP3R2(2), PTK2(3), RAC1(3), RASA1(3), RGS3(3), RHOD(1), RND1(1), ROBO1(7), ROBO2(11), ROBO3(3), ROCK2(2), SEMA3A(2), SEMA3D(2), SEMA3E(7), SEMA3F(3), SEMA3G(1), SEMA4A(4), SEMA4B(1), SEMA4C(2), SEMA4D(2), SEMA4G(2), SEMA5A(6), SEMA5B(4), SEMA6A(2), SEMA6B(1), SEMA6C(2), SEMA6D(1), SLIT1(5), SLIT2(17), SLIT3(6), SRGAP1(3), SRGAP2(1), SRGAP3(8), UNC5A(3), UNC5B(1), UNC5C(3), UNC5D(5) 17430660 321 58 319 141 213 27 10 39 32 0 0.00495 1.000 1.000 303 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(5), ADCY2(5), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(2), ADCY8(8), ADCY9(1), ADRA1A(1), ADRB1(1), ADRB2(1), ANXA6(1), ARRB1(2), ARRB2(2), ATP1A4(3), ATP2A2(2), ATP2A3(3), ATP2B1(1), ATP2B2(5), ATP2B3(1), CACNA1A(7), CACNA1B(4), CACNA1C(13), CACNA1D(10), CACNA1E(24), CACNA1S(10), CALM1(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CAMK4(1), CASQ1(2), CHRM2(6), CHRM3(3), CHRM4(2), GJA1(2), GJA4(2), GJA5(1), GJB1(1), GJB3(1), GJB5(1), GJB6(3), GNA11(2), GNAI3(1), GNAO1(1), GNAQ(1), GNAZ(1), GNB3(2), GNB4(1), GNG2(1), GNG4(1), GRK4(3), GRK5(1), GRK6(1), ITPR1(4), ITPR2(8), ITPR3(2), KCNB1(6), KCNJ3(4), KCNJ5(2), NME7(2), PKIA(1), PRKACA(1), PRKAR2B(1), PRKCA(1), PRKCD(1), PRKCG(4), PRKCH(1), PRKCQ(4), PRKCZ(2), RGS14(1), RGS16(2), RGS18(3), RGS3(3), RGS5(1), RGS6(1), RGS7(9), RGS9(2), RYR1(15), RYR2(20), RYR3(16), SLC8A1(8), SLC8A3(12), USP5(2) 16945211 302 57 297 209 210 21 15 27 29 0 0.624 1.000 1.000 304 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 248 ACVR1B(1), ACVR2A(1), AMHR2(4), BMP2(1), BMP7(1), BMPR1B(2), CCL14(1), CCL20(1), CCL22(1), CCL26(1), CCL27(1), CCL7(1), CCR1(5), CCR3(4), CCR4(3), CCR7(1), CCR8(2), CCR9(2), CD27(1), CD40(2), CSF1(1), CSF2RA(3), CSF2RB(3), CSF3(2), CSF3R(1), CX3CL1(3), CX3CR1(3), CXCL12(1), CXCL14(1), CXCL3(1), CXCL6(1), CXCR3(1), CXCR4(1), CXCR6(1), EDAR(3), EGF(4), EGFR(6), EPO(1), EPOR(1), FAS(2), FASLG(5), FLT1(9), FLT3(6), FLT4(5), GDF5(1), GH2(1), GHR(4), HGF(7), IFNA16(1), IFNA2(1), IFNA21(1), IFNA4(1), IFNA8(1), IFNB1(2), IFNGR1(3), IFNGR2(1), IFNK(1), IFNW1(3), IL10(1), IL10RB(4), IL12A(1), IL12RB1(3), IL12RB2(1), IL15(1), IL17A(1), IL17RA(2), IL18R1(8), IL18RAP(3), IL19(1), IL1A(1), IL1B(2), IL1R1(5), IL1R2(2), IL2(1), IL20(1), IL20RA(4), IL21(2), IL21R(4), IL22(1), IL22RA1(2), IL23R(1), IL28B(1), IL2RA(1), IL2RG(1), IL3RA(1), IL4R(6), IL5(1), IL5RA(2), IL6(1), IL6R(2), IL6ST(2), IL7(2), IL7R(6), INHBA(3), INHBB(1), INHBC(1), INHBE(2), KDR(10), KIT(2), KITLG(4), LEPR(7), LIF(2), LIFR(10), LTB(1), MET(6), MPL(2), NGFR(3), OSM(1), PDGFB(2), PDGFC(2), PDGFRA(7), PDGFRB(3), PLEKHO2(3), PPBP(1), PRL(1), PRLR(5), RELT(1), TGFB1(1), TGFB3(1), TGFBR2(3), TNFRSF10D(3), TNFRSF11B(3), TNFRSF12A(1), TNFRSF13B(2), TNFRSF14(1), TNFRSF17(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(4), TNFRSF25(1), TNFRSF8(4), TNFRSF9(1), TNFSF10(2), TNFSF13B(1), TNFSF14(3), TNFSF18(2), TNFSF4(2), TPO(8), TSLP(1), VEGFA(3), VEGFC(3), XCL2(1), XCR1(1) 15795965 343 57 339 164 248 19 9 33 34 0 0.0184 1.000 1.000 305 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTG1(1), ACTN1(1), ACTN2(3), ACTN3(2), ACTN4(3), AKT2(4), AKT3(2), ASH1L(4), CDK4(1), CGN(2), CLDN1(1), CLDN11(1), CLDN16(1), CLDN17(1), CLDN4(3), CLDN6(2), CLDN7(1), CLDN8(1), CSNK2A2(1), CTNNA2(4), CTNNA3(6), CTNNB1(1), CTTN(1), EPB41(3), EPB41L1(2), EPB41L2(3), EPB41L3(2), GNAI3(1), HCLS1(2), HRAS(1), IGSF5(3), INADL(3), JAM2(2), LLGL2(3), MAGI1(3), MAGI2(5), MAGI3(2), MLLT4(3), MPDZ(4), MYH1(19), MYH10(4), MYH11(7), MYH13(5), MYH14(3), MYH15(13), MYH2(26), MYH3(6), MYH4(23), MYH6(4), MYH7(11), MYH7B(3), MYH8(13), MYH9(7), MYL2(3), MYL7(1), MYLPF(1), OCLN(1), PARD3(3), PARD6G(2), PPP2CA(1), PPP2CB(1), PPP2R2B(2), PPP2R2C(4), PPP2R3A(2), PPP2R3B(1), PRKCA(1), PRKCD(1), PRKCG(4), PRKCH(1), PRKCI(1), PRKCQ(4), PRKCZ(2), PTEN(4), RRAS(1), SPTAN1(1), SYMPK(1), TJAP1(1), TJP1(3), TJP2(3), TJP3(3), VAPA(1), ZAK(3) 17533172 290 57 285 181 191 21 11 32 35 0 0.652 1.000 1.000 306 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(2), ACTA2(2), ADCY1(5), ADCY2(5), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(2), ADCY8(8), ADCY9(1), ARRB1(2), ARRB2(2), ATF1(1), ATF4(2), ATF5(3), ATP2A2(2), ATP2A3(3), CALM1(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CORIN(9), CRH(1), CRHR1(2), DGKZ(1), ETS2(3), FOS(1), GABPB2(2), GBA2(1), GJA1(2), GNAQ(1), GNB3(2), GNB4(1), GNG2(1), GNG4(1), GRK4(3), GRK5(1), GRK6(1), GSTO1(1), GUCA2B(1), GUCY1A3(7), IGFBP3(2), IL1B(2), IL6(1), ITPR1(4), ITPR2(8), ITPR3(2), MYL2(3), MYL4(2), MYLK2(2), NFKB1(3), NOS1(11), NOS3(2), OXTR(2), PDE4B(3), PDE4D(1), PKIA(1), PLCG2(6), PRKACA(1), PRKAR2B(1), PRKCA(1), PRKCD(1), PRKCH(1), PRKCQ(4), PRKCZ(2), RAMP3(1), RGS14(1), RGS16(2), RGS18(3), RGS3(3), RGS5(1), RGS6(1), RGS7(9), RGS9(2), RYR1(15), RYR2(20), RYR3(16), SLC8A1(8), TNXB(29), USP5(2) 15827885 271 57 265 159 183 20 13 31 24 0 0.314 1.000 1.000 307 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(2), ACTA2(2), ACTN2(3), ACTN3(2), ACTN4(3), DES(2), DMD(4), MYBPC1(4), MYBPC2(4), MYBPC3(4), MYH3(6), MYH6(4), MYH7(11), MYH8(13), MYL1(1), MYL2(3), MYL4(2), MYOM1(10), NEB(20), TNNI2(1), TNNT2(1), TNNT3(1), TTN(251), VIM(1) 12025657 355 56 344 149 256 25 15 32 25 2 0.00695 1.000 1.000 308 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 158 ADORA1(2), ADORA2A(1), ADORA2B(1), ADORA3(2), ADRA1A(1), ADRB1(1), ADRB2(1), AGTR1(4), AGTR2(2), AVPR1B(3), BDKRB2(3), C3AR1(3), CCKAR(4), CCKBR(5), CCR1(5), CCR3(4), CCR4(3), CCR7(1), CCR8(2), CCR9(2), CCRL2(2), CHRM2(6), CHRM3(3), CHRM4(2), CMKLR1(2), CNR1(3), CX3CR1(3), CXCR3(1), CXCR4(1), DRD1(3), DRD2(2), DRD3(3), DRD5(3), EDNRA(2), EDNRB(1), F2R(2), F2RL2(1), F2RL3(1), FPR1(5), FSHR(3), GALR1(2), GNB2L1(2), GPR174(3), GPR27(1), GPR3(1), GPR35(1), GPR37L1(3), GPR4(1), GPR50(5), GPR63(3), GPR77(1), GPR83(1), GPR87(2), GRPR(1), HRH1(3), HRH2(2), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(1), HTR1F(2), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(1), HTR5A(7), HTR7(2), LHCGR(7), LTB4R(1), MC3R(1), MC4R(1), MC5R(1), MTNR1A(4), MTNR1B(2), NMBR(2), NMUR2(1), NPY1R(5), NPY2R(3), NPY5R(6), NTSR2(1), OPN1SW(1), OPRK1(3), OPRM1(1), OR10A5(1), OR11A1(1), OR12D3(2), OR1C1(1), OR1F1(2), OR1Q1(2), OR2H1(2), OR5V1(6), OR7A5(2), OR8B8(3), OXTR(2), P2RY10(1), P2RY13(2), P2RY14(3), P2RY2(2), PPYR1(1), PTGDR(2), PTGER2(1), PTGER4(1), PTGFR(6), RGR(1), SSTR2(2), SSTR4(3), SUCNR1(1), TRHR(5) 10710679 251 55 249 199 167 17 13 30 24 0 0.316 1.000 1.000 309 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 129 CADM3(1), CD2(3), CD22(4), CD226(3), CD276(1), CD34(2), CD40(2), CD58(1), CD6(1), CD80(1), CD8A(1), CD8B(2), CDH15(3), CDH2(2), CDH4(4), CLDN1(1), CLDN11(1), CLDN16(1), CLDN17(1), CLDN4(3), CLDN6(2), CLDN7(1), CLDN8(1), CNTN1(4), CNTN2(3), CNTNAP1(4), CNTNAP2(19), CTLA4(2), GLG1(1), HLA-A(2), HLA-B(1), HLA-C(1), HLA-DMA(2), HLA-DOA(1), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(2), HLA-DRA(3), HLA-DRB5(1), HLA-E(1), HLA-F(4), ICAM1(1), ICAM2(2), ITGA4(5), ITGA6(2), ITGA8(9), ITGA9(2), ITGAL(3), ITGAM(3), ITGAV(3), ITGB1(1), ITGB2(4), ITGB7(2), ITGB8(3), JAM2(2), MAG(3), MPZ(1), NCAM1(3), NCAM2(1), NEGR1(1), NEO1(1), NFASC(5), NLGN1(2), NLGN2(1), NLGN3(3), NRXN1(6), NRXN2(3), NRXN3(4), OCLN(1), PDCD1(1), PTPRC(3), PTPRF(5), PTPRM(2), PVRL2(3), PVRL3(2), SDC1(2), SDC2(1), SELE(9), SELL(1), SELP(8), SELPLG(2), SIGLEC1(4), SPN(1), VCAM1(5), VCAN(6) 13261577 228 55 226 138 148 17 11 25 27 0 0.642 1.000 1.000 310 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 130 ACACA(7), ACACB(7), AKT2(4), AKT3(2), ARAF(2), BRAF(3), CALM1(1), CALML3(1), CBL(3), CBLB(4), CBLC(2), EXOC7(1), FASN(5), FBP2(1), FOXO1(1), G6PC(2), G6PC2(1), GCK(3), GYS2(5), HRAS(1), INPP5D(7), INSR(2), IRS1(3), IRS2(1), IRS4(2), LIPE(1), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK10(2), MAPK3(1), PCK1(4), PCK2(3), PDE3A(8), PDE3B(1), PHKA1(3), PHKA2(4), PHKB(1), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PKLR(2), PKM2(1), PPARGC1A(5), PPP1CB(1), PPP1R3A(14), PPP1R3B(1), PRKAA2(5), PRKAB2(1), PRKACA(1), PRKACG(2), PRKAG1(1), PRKAG2(1), PRKAG3(5), PRKAR2B(1), PRKCI(1), PRKCZ(2), PRKX(1), PTPN1(3), PTPRF(5), PYGB(1), PYGL(3), PYGM(3), RAF1(2), RAPGEF1(4), RHOQ(1), RPS6(1), RPS6KB1(1), RPS6KB2(2), SH2B2(2), SHC2(2), SHC3(4), SHC4(1), SLC2A4(1), SOCS3(1), SORBS1(5), SOS1(1), SOS2(2), SREBF1(1), TRIP10(1), TSC1(1), TSC2(6) 14515602 226 55 224 97 144 18 13 34 16 1 0.0351 1.000 1.000 311 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT2(4), AKT3(2), CBL(3), CBLB(4), CBLC(2), CCND2(1), CREBBP(6), CSF2RA(3), CSF2RB(3), CSF3(2), CSF3R(1), EP300(4), EPO(1), EPOR(1), GH2(1), GHR(4), IFNA16(1), IFNA2(1), IFNA21(1), IFNA4(1), IFNA8(1), IFNB1(2), IFNGR1(3), IFNGR2(1), IFNK(1), IFNW1(3), IL10(1), IL10RB(4), IL12A(1), IL12RB1(3), IL12RB2(1), IL15(1), IL19(1), IL2(1), IL20(1), IL20RA(4), IL21(2), IL21R(4), IL22(1), IL22RA1(2), IL23R(1), IL28B(1), IL2RA(1), IL2RG(1), IL3RA(1), IL4R(6), IL5(1), IL5RA(2), IL6(1), IL6R(2), IL6ST(2), IL7(2), IL7R(6), JAK1(1), JAK2(1), JAK3(2), LEPR(7), LIF(2), LIFR(10), MPL(2), MYC(2), OSM(1), PIAS1(1), PIAS3(1), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PRL(1), PRLR(5), PTPN11(1), SOCS3(1), SOCS5(1), SOCS7(1), SOS1(1), SOS2(2), SPRED1(2), SPRY1(3), SPRY3(1), SPRY4(1), STAT1(2), STAT4(1), STAT5B(1), STAT6(1), TPO(8), TSLP(1), TYK2(3) 13040999 198 54 194 103 133 16 6 25 18 0 0.512 1.000 1.000 312 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(2), ADCY1(5), ADCY2(5), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(2), ADCY8(8), ADCY9(1), ADK(1), ADSSL1(1), AK2(1), AK5(2), AK7(5), ALLC(2), AMPD1(5), AMPD2(1), AMPD3(7), ATIC(1), CANT1(3), DGUOK(1), ENPP3(4), ENTPD1(1), ENTPD3(2), ENTPD4(1), ENTPD6(1), ENTPD8(1), GART(4), GDA(3), GMPR2(1), GMPS(1), GUCY1A2(3), GUCY1A3(7), GUCY1B3(2), GUCY2C(8), GUCY2D(2), GUCY2F(3), NME6(1), NME7(2), NPR1(5), NPR2(2), NT5C1A(1), NT5C1B(4), NT5C2(1), PAPSS2(1), PDE10A(3), PDE11A(2), PDE1A(7), PDE1C(11), PDE2A(4), PDE3B(1), PDE4A(3), PDE4B(3), PDE4C(4), PDE4D(1), PDE5A(2), PDE6D(1), PDE6G(1), PDE7B(6), PDE8A(1), PDE8B(2), PFAS(2), PKLR(2), PKM2(1), POLA1(1), POLA2(3), POLD1(2), POLD3(1), POLE(1), POLE2(1), POLR1A(3), POLR1B(1), POLR2A(4), POLR2B(3), POLR2E(1), POLR2F(1), POLR2J(1), POLR2L(1), POLR3A(1), POLR3B(2), PRIM2(3), PRPS1L1(4), RRM1(1), XDH(14) 14882484 225 53 223 113 150 15 10 33 17 0 0.135 1.000 1.000 313 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 65 ADH1A(2), ADH1C(8), ADH4(2), ADH5(1), ADH7(5), ADHFE1(3), AKR1C2(1), AKR1C3(3), AKR1C4(3), ALDH3A1(1), ALDH3B2(1), CYP1A1(3), CYP1A2(2), CYP2B6(5), CYP2C18(5), CYP2C19(17), CYP2C8(8), CYP2C9(9), CYP2E1(1), CYP2F1(1), CYP2S1(1), CYP3A4(4), CYP3A43(4), CYP3A5(3), CYP3A7(3), EPHX1(2), GSTA1(1), GSTA2(1), GSTA5(1), GSTK1(1), GSTM1(1), GSTM4(1), GSTM5(3), GSTP1(1), GSTT1(1), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A7(4), UGT1A8(1), UGT2A1(5), UGT2B10(5), UGT2B11(6), UGT2B15(5), UGT2B7(6) 4853569 146 52 142 78 100 9 16 9 12 0 0.155 1.000 1.000 314 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 108 ABL1(3), ANAPC1(3), ANAPC10(1), ANAPC2(2), ANAPC4(2), ANAPC7(1), ATM(4), ATR(4), BUB1(2), CCNA1(3), CCNB3(7), CCND2(1), CCNE2(3), CCNH(2), CDC14A(2), CDC16(1), CDC25A(3), CDC25B(3), CDC25C(2), CDC27(5), CDC6(1), CDK4(1), CDKN1A(3), CREBBP(6), CUL1(1), DBF4(1), E2F1(1), E2F2(2), EP300(4), ESPL1(2), FZR1(2), GADD45B(2), MAD1L1(1), MAD2L1(1), MCM2(2), MCM3(3), MCM4(1), MCM5(1), MDM2(1), ORC1L(1), ORC2L(1), ORC3L(1), ORC4L(2), ORC6L(1), PKMYT1(1), PLK1(2), PRKDC(3), PTTG2(2), RB1(3), RBL1(3), RBL2(1), SKP2(1), SMAD2(1), SMAD3(1), SMC1A(2), SMC1B(5), TFDP1(1), TGFB1(1), TGFB3(1) 12311368 124 52 124 40 67 12 10 17 18 0 0.0218 1.000 1.000 315 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 143 APC(4), APC2(2), AXIN1(2), CACYBP(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CCND2(1), CER1(2), CHD8(2), CHP(2), CREBBP(6), CSNK1A1(1), CSNK1A1L(1), CSNK2A2(1), CTNNB1(1), CUL1(1), CXXC4(1), DAAM1(2), DAAM2(1), DKK2(4), DKK4(1), DVL2(3), EP300(4), FZD1(1), FZD2(1), FZD5(1), FZD7(1), FZD8(1), FZD9(1), LEF1(1), LRP5(3), LRP6(5), MAP3K7(1), MAPK10(2), MYC(2), NFAT5(2), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), NKD1(2), NKD2(1), NLK(3), PLCB1(13), PLCB2(4), PLCB4(13), PORCN(1), PPARD(1), PPP2CA(1), PPP2CB(1), PPP2R2B(2), PPP2R2C(4), PPP3R2(2), PRICKLE1(1), PRICKLE2(2), PRKACA(1), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(1), RAC1(3), ROCK2(2), SENP2(3), SFRP1(1), SFRP2(3), SMAD2(1), SMAD3(1), TBL1X(1), TBL1Y(1), TCF7L1(1), VANGL2(1), WIF1(2), WNT10A(2), WNT11(1), WNT3(1), WNT3A(4), WNT4(1), WNT5A(1), WNT5B(1), WNT7A(2), WNT8B(3), WNT9B(1) 14552828 178 52 174 97 117 13 10 22 16 0 0.581 1.000 1.000 316 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 91 ADCY1(5), ADCY2(5), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(2), ADCY8(8), ADCY9(1), ADRB1(1), DRD1(3), DRD2(2), EGF(4), EGFR(6), GJA1(2), GJD2(1), GNA11(2), GNAI3(1), GNAQ(1), GNAS(6), GRM1(3), GRM5(3), GUCY1A2(3), GUCY1A3(7), GUCY1B3(2), GUCY2C(8), GUCY2D(2), GUCY2F(3), HRAS(1), HTR2A(2), HTR2B(2), HTR2C(4), ITPR1(4), ITPR2(8), ITPR3(2), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), MAPK7(2), NPR1(5), NPR2(2), PDGFB(2), PDGFC(2), PDGFD(1), PDGFRA(7), PDGFRB(3), PLCB1(13), PLCB2(4), PLCB4(13), PRKACA(1), PRKACG(2), PRKCA(1), PRKCG(4), PRKG1(1), PRKG2(3), PRKX(1), RAF1(2), SOS1(1), SOS2(2), TJP1(3), TUBA3C(9), TUBA3D(5), TUBA4A(1), TUBA8(2), TUBAL3(6), TUBB2A(1), TUBB4Q(4), TUBB6(2), TUBB8(5) 11929116 228 52 221 112 155 13 12 23 25 0 0.0230 1.000 1.000 317 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CALM1(1), CALML3(1), CDS2(1), DGKA(1), DGKB(5), DGKD(2), DGKE(4), DGKG(4), DGKH(2), DGKI(4), DGKQ(2), DGKZ(1), INPP5A(1), INPP5B(1), INPP5D(7), INPPL1(4), ITPK1(2), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(2), OCRL(1), PI4KA(6), PI4KB(1), PIK3C2A(3), PIK3C2B(5), PIK3C3(2), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PIP4K2B(1), PIP5K1A(2), PIP5K1B(6), PIP5K1C(2), PLCB1(13), PLCB2(4), PLCB4(13), PLCD3(3), PLCE1(11), PLCG2(6), PLCZ1(6), PRKCA(1), PRKCG(4), PTEN(4), SYNJ1(3), SYNJ2(2) 11060940 178 51 173 68 113 10 5 28 22 0 0.00433 1.000 1.000 318 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 124 ARAF(2), BRAF(3), CASP3(1), CD244(2), CD247(1), CHP(2), FAS(2), FASLG(5), FCGR3A(2), FCGR3B(1), FYN(2), GZMB(1), HLA-A(2), HLA-B(1), HLA-C(1), HLA-E(1), HRAS(1), ICAM1(1), ICAM2(2), IFNA16(1), IFNA2(1), IFNA21(1), IFNA4(1), IFNA8(1), IFNB1(2), IFNGR1(3), IFNGR2(1), ITGAL(3), ITGB2(4), KIR2DL1(2), KIR3DL1(1), KIR3DL2(2), KLRC1(1), KLRK1(1), LCK(4), LCP2(4), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), MICA(1), MICB(1), NCR1(3), NCR2(5), NCR3(1), NFAT5(2), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), PAK1(1), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PLCG2(6), PPP3R2(2), PRF1(3), PRKCA(1), PRKCG(4), PTPN11(1), RAC1(3), RAF1(2), SH3BP2(1), SHC2(2), SHC3(4), SHC4(1), SOS1(1), SOS2(2), SYK(3), TNFRSF10D(3), TNFSF10(2), TYROBP(2), VAV1(3), VAV2(2), VAV3(4), ZAP70(3) 10187393 175 51 171 83 122 7 7 25 14 0 0.214 1.000 1.000 319 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT3(2), BCAR1(1), CAPN1(1), CAPN10(1), CAPN11(2), CAPN2(1), CAPN3(4), CAPN5(2), CAPN6(2), CAPN9(3), DOCK1(5), FYN(2), GIT2(2), ITGA10(3), ITGA11(4), ITGA2(4), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(5), ITGA6(2), ITGA7(6), ITGA8(9), ITGA9(2), ITGAD(4), ITGAE(2), ITGAL(3), ITGAM(3), ITGAV(3), ITGAX(1), ITGB1(1), ITGB2(4), ITGB3(3), ITGB4(5), ITGB5(2), ITGB6(3), ITGB7(2), ITGB8(3), MAP2K1(4), MAP2K2(1), MAP2K3(2), MAPK10(2), MAPK4(4), MAPK6(2), MAPK7(2), MYLK2(2), PAK1(1), PAK6(2), PTK2(3), RAC1(3), RAP1B(1), RAPGEF1(4), ROCK2(2), SHC3(4), SORBS1(5), SOS1(1), TLN1(4), TNS1(2), VASP(1), VAV2(2), VAV3(4), VCL(3), ZYX(1) 12111128 174 51 172 76 118 14 4 22 16 0 0.0368 1.000 1.000 320 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 66 ADCY1(5), ADCY8(8), ARAF(2), ATF4(2), BRAF(3), CACNA1C(13), CALM1(1), CALML3(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CAMK4(1), CHP(2), CREBBP(6), EP300(4), GNAQ(1), GRIA1(7), GRIA2(11), GRIN1(2), GRIN2A(15), GRIN2B(11), GRIN2C(1), GRIN2D(3), GRM1(3), GRM5(3), HRAS(1), ITPR1(4), ITPR2(8), ITPR3(2), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), PLCB1(13), PLCB2(4), PLCB4(13), PPP1CB(1), PPP1R1A(1), PPP3R2(2), PRKACA(1), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(1), RAF1(2), RAP1A(1), RAP1B(1), RAPGEF3(3), RPS6KA1(3), RPS6KA3(1), RPS6KA6(4) 8921792 191 50 187 103 128 14 5 26 18 0 0.225 1.000 1.000 321 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 73 ARAF(2), BRAF(3), CACNA1A(7), CRH(1), CRHR1(2), GNA11(2), GNA12(1), GNAI3(1), GNAO1(1), GNAQ(1), GNAS(6), GNAZ(1), GRIA1(7), GRIA2(11), GRIA3(3), GRID2(11), GRM1(3), GRM5(3), GUCY1A2(3), GUCY1A3(7), GUCY1B3(2), GUCY2C(8), GUCY2D(2), GUCY2F(3), HRAS(1), IGF1(2), IGF1R(1), ITPR1(4), ITPR2(8), ITPR3(2), LYN(1), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), NOS1(11), NOS3(2), NPR1(5), NPR2(2), PLA2G1B(1), PLA2G2D(1), PLA2G2F(2), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), PLCB1(13), PLCB2(4), PLCB4(13), PPP2CA(1), PPP2CB(1), PPP2R2B(2), PPP2R2C(4), PRKCA(1), PRKCG(4), PRKG1(1), PRKG2(3), RAF1(2), RYR1(15) 9904287 217 50 209 133 149 11 6 28 23 0 0.583 1.000 1.000 322 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(3), CD14(2), CD19(1), CD1A(2), CD1B(4), CD1C(6), CD1D(2), CD1E(2), CD2(3), CD22(4), CD33(4), CD34(2), CD36(1), CD3D(1), CD3G(1), CD5(3), CD59(1), CD8A(1), CD8B(2), CR1(16), CR2(7), CSF1(1), CSF2RA(3), CSF3(2), CSF3R(1), DNTT(2), EPO(1), EPOR(1), FCER2(1), FCGR1A(3), FLT3(6), GP5(3), HLA-DRA(3), HLA-DRB5(1), IL1A(1), IL1B(2), IL1R1(5), IL1R2(2), IL2RA(1), IL3RA(1), IL4R(6), IL5(1), IL5RA(2), IL6(1), IL6R(2), IL7(2), IL7R(6), ITGA1(4), ITGA2(4), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(5), ITGA6(2), ITGAM(3), ITGB3(3), KIT(2), KITLG(4), MME(5), MS4A1(2), TFRC(1), THPO(1), TPO(8) 7401774 182 49 179 89 138 8 7 8 21 0 0.122 1.000 1.000 323 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(1), ACTN2(3), ACTN3(2), ACTN4(3), ARHGAP5(3), BCAR1(1), CLDN1(1), CLDN11(1), CLDN16(1), CLDN17(1), CLDN4(3), CLDN6(2), CLDN7(1), CLDN8(1), CTNNA2(4), CTNNA3(6), CTNNB1(1), CXCL12(1), CXCR4(1), CYBA(1), GNAI3(1), GRLF1(1), ICAM1(1), ITGA4(5), ITGAL(3), ITGAM(3), ITGB1(1), ITGB2(4), ITK(3), JAM2(2), MLLT4(3), MMP2(1), MMP9(2), MYL2(3), MYL7(1), MYLPF(1), NCF2(2), NOX1(4), OCLN(1), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PLCG2(6), PRKCA(1), PRKCG(4), PTK2(3), PTPN11(1), RAC1(3), RAP1A(1), RAP1B(1), RAPGEF3(3), RAPGEF4(7), RASSF5(1), ROCK2(2), TXK(3), VASP(1), VAV1(3), VAV2(2), VAV3(4), VCAM1(5), VCL(3) 11242629 154 49 149 97 101 10 5 23 15 0 0.768 1.000 1.000 324 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 76 ABL1(3), ACTN1(1), ACTR2(2), ACTR3(2), AKT2(4), AKT3(2), ARHGEF6(3), ARHGEF7(2), BCAR1(1), BRAF(3), DOCK1(5), EPHB2(4), FYN(2), GRLF1(1), ITGA1(4), ITGA10(3), ITGA11(4), ITGA2(4), ITGA3(3), ITGA4(5), ITGA5(5), ITGA6(2), ITGA7(6), ITGA8(9), ITGA9(2), MAP2K4(1), MAP2K7(1), MAP3K11(3), MAPK1(3), MAPK10(2), MAPK8IP2(2), MAPK8IP3(3), MYLK(11), MYLK2(2), PAK1(1), PAK6(2), PIK3CA(1), PIK3CB(7), PKLR(2), PLCG2(6), PTEN(4), PTK2(3), RAF1(2), ROCK2(2), SOS1(1), SOS2(2), TERF2IP(1), TLN1(4), TLN2(6), VASP(1), WAS(1), ZYX(1) 10892211 157 49 153 61 98 13 6 21 19 0 0.0240 1.000 1.000 325 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 BCL2(1), CABIN1(2), CALM1(1), CAMK2B(2), CAMK4(1), CD3G(1), CDKN1A(3), CNR1(3), CREBBP(6), CTLA4(2), EGR2(1), EP300(4), FCER1A(4), FCGR3A(2), FOS(1), GATA3(3), GATA4(1), GRLF1(1), HRAS(1), IFNB1(2), IL10(1), IL1B(2), IL2(1), IL2RA(1), IL6(1), ITK(3), MAP2K7(1), MEF2A(2), MEF2B(1), MEF2D(2), MYF5(2), NCK2(1), NFAT5(2), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), NFKB2(2), NPPB(1), NUP214(1), P2RX7(2), PAK1(1), PPIA(1), PTPRC(3), RELA(2), TGFB1(1), TRPV6(6), VAV1(3), VAV2(2), VAV3(4), XPO5(5) 8300230 107 48 106 48 70 7 6 11 13 0 0.184 1.000 1.000 326 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 76 AGL(3), AMY2B(2), ASCC3(1), DDX18(1), DDX19A(1), DDX23(1), DDX4(2), DDX41(1), DDX50(2), DDX51(2), DDX52(1), DHX58(1), ENPP3(4), EP400(6), G6PC(2), G6PC2(1), GAA(4), GBA(1), GBA3(6), GBE1(2), GCK(3), GYS2(5), HK1(1), HK2(1), HK3(2), IFIH1(2), MOV10L1(5), PYGB(1), PYGL(3), PYGM(3), RUVBL2(1), SETX(3), SI(19), SKIV2L2(1), SMARCA2(4), SMARCA5(1), TREH(1), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A7(4), UGT1A8(1), UGT2A1(5), UGT2B10(5), UGT2B11(6), UGT2B15(5), UGT2B7(6), UXS1(1) 10585925 138 48 136 85 85 15 10 13 15 0 0.830 1.000 1.000 327 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(4), ABCA10(6), ABCA12(14), ABCA13(17), ABCA3(3), ABCA4(11), ABCA5(1), ABCA6(4), ABCA7(2), ABCA8(4), ABCA9(4), ABCB1(5), ABCB10(1), ABCB11(12), ABCB4(2), ABCB5(1), ABCB7(1), ABCB8(1), ABCB9(2), ABCC1(3), ABCC10(1), ABCC11(4), ABCC12(2), ABCC2(2), ABCC3(6), ABCC4(5), ABCC5(1), ABCC6(4), ABCC8(10), ABCC9(7), ABCD2(4), ABCD3(2), ABCG1(3), ABCG2(1), ABCG4(1), ABCG5(1), ABCG8(3), CFTR(11), TAP1(1), TAP2(1) 10736055 168 48 166 112 109 13 11 19 16 0 0.605 1.000 1.000 328 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 83 ABL1(3), ABL2(2), AKT2(4), AKT3(2), ARAF(2), AREG(1), BRAF(3), CAMK2B(2), CAMK2D(1), CAMK2G(1), CBL(3), CBLB(4), CBLC(2), CDKN1A(3), EGF(4), EGFR(6), ERBB2(3), ERBB3(1), ERBB4(12), EREG(1), HRAS(1), MAP2K1(4), MAP2K2(1), MAP2K4(1), MAP2K7(1), MAPK1(3), MAPK10(2), MAPK3(1), MYC(2), NCK1(1), NCK2(1), NRG1(5), NRG3(6), PAK1(1), PAK6(2), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PLCG2(6), PRKCA(1), PRKCG(4), PTK2(3), RAF1(2), RPS6KB1(1), RPS6KB2(2), SHC2(2), SHC3(4), SHC4(1), SOS1(1), SOS2(2), STAT5B(1) 9163763 142 48 138 49 83 10 8 26 15 0 0.0192 1.000 1.000 329 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(3), CPEB1(2), EGFR(6), ERBB2(3), ERBB4(12), ETS1(1), ETS2(3), ETV6(4), FMN2(16), MAP2K1(4), MAPK1(3), MAPK3(1), NOTCH1(1), NOTCH2(9), NOTCH3(6), NOTCH4(13), PIWIL1(6), PIWIL2(2), PIWIL4(1), RAF1(2), SOS1(1), SOS2(2), SPIRE1(1), SPIRE2(2) 4793779 104 48 104 32 68 5 5 16 10 0 0.0204 1.000 1.000 330 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1B(1), ACVR1C(3), ACVR2A(1), ACVRL1(2), AMHR2(4), BMP2(1), BMP4(1), BMP5(8), BMP6(2), BMP7(1), BMP8A(1), BMPR1B(2), CHRD(3), CREBBP(6), CUL1(1), DCN(4), E2F5(1), EP300(4), GDF5(1), INHBA(3), INHBB(1), INHBC(1), INHBE(2), LEFTY1(1), LTBP1(8), MAPK1(3), MAPK3(1), MYC(2), PITX2(2), PPP2CA(1), PPP2CB(1), PPP2R2B(2), PPP2R2C(4), RBL1(3), RBL2(1), ROCK2(2), RPS6KB1(1), RPS6KB2(2), SMAD1(1), SMAD2(1), SMAD3(1), SMAD6(3), SMURF1(1), SMURF2(3), TFDP1(1), TGFB1(1), TGFB3(1), TGFBR2(3), THBS1(3), THBS2(2), THBS3(2), THBS4(2), ZFYVE16(2), ZFYVE9(1) 9051523 116 48 116 49 76 9 8 13 10 0 0.203 1.000 1.000 331 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(1), ACTG1(1), ACTN1(1), ACTN2(3), ACTN3(2), ACTN4(3), ACVR1B(1), ACVR1C(3), CREBBP(6), CSNK2A2(1), CTNNA2(4), CTNNA3(6), CTNNB1(1), EGFR(6), EP300(4), ERBB2(3), FGFR1(4), FYN(2), IGF1R(1), INSR(2), IQGAP1(1), LEF1(1), LMO7(8), MAP3K7(1), MAPK1(3), MAPK3(1), MET(6), MLLT4(3), NLK(3), PARD3(3), PTPN1(3), PTPRB(25), PTPRF(5), PTPRJ(1), PTPRM(2), PVRL2(3), PVRL3(2), RAC1(3), SMAD2(1), SMAD3(1), SORBS1(5), SSX2IP(1), TCF7L1(1), TGFBR2(3), TJP1(3), VCL(3), WAS(1), WASF1(1), WASL(2) 10949269 151 48 147 68 96 9 9 16 21 0 0.225 1.000 1.000 332 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(1), CLK2(2), COL2A1(9), CPSF1(3), CPSF3(2), CSTF2(2), DDIT3(1), DDX20(2), DHX15(1), DHX16(3), DHX38(1), DHX8(3), DHX9(1), DICER1(7), DNAJC8(1), GIPC1(2), LOC440563(5), LSM2(1), METTL3(1), NONO(1), NUDT21(1), PABPN1(1), PAPOLA(2), PHF5A(1), POLR2A(4), PPM1G(1), PRPF18(1), PRPF4B(2), PRPF8(2), RBM5(3), RNMT(3), RNPS1(1), SF3A1(2), SF3B1(3), SF3B2(1), SF3B4(2), SF4(3), SFRS12(1), SFRS14(3), SFRS4(2), SFRS5(1), SFRS6(1), SFRS8(2), SFRS9(1), SNRPA(1), SNRPA1(1), SNRPB(1), SNRPD1(1), SNURF(1), SPOP(1), SRPK1(1), SRRM1(2), SUPT5H(3), U2AF2(2), XRN2(3) 9692495 110 48 110 47 69 5 3 16 17 0 0.496 1.000 1.000 333 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(2), ADCY1(5), ADCY2(5), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(2), ADCY8(8), ADK(1), AK2(1), AK5(2), ALLC(2), AMPD1(5), AMPD2(1), AMPD3(7), ATIC(1), ATP5F1(1), CANT1(3), DGUOK(1), ENPP3(4), ENTPD1(1), GART(4), GDA(3), GMPS(1), GUCY1A2(3), GUCY1A3(7), GUCY1B3(2), GUCY2C(8), GUCY2D(2), GUCY2F(3), NPR1(5), NPR2(2), PAPSS2(1), PDE1A(7), PDE4A(3), PDE4B(3), PDE4C(4), PDE4D(1), PDE5A(2), PDE6B(4), PDE6C(4), PDE6G(1), PDE7B(6), PDE8A(1), PFAS(2), PKLR(2), PKM2(1), POLD1(2), POLE(1), POLG(1), POLL(1), POLQ(5), POLR1B(1), POLR2A(4), POLR2B(3), POLR2E(1), POLR2F(1), POLR2J(1), POLR2L(1), POLRMT(1), PRPS1L1(4), RRM1(1) 11643402 167 48 167 91 110 15 7 20 15 0 0.280 1.000 1.000 334 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 90 AKT2(4), AKT3(2), BCL10(1), CARD11(8), CBL(3), CBLB(4), CBLC(2), CD247(1), CD3D(1), CD3G(1), CD8A(1), CD8B(2), CDK4(1), CHP(2), CTLA4(2), FOS(1), FYN(2), GRAP2(2), HRAS(1), IL10(1), IL2(1), IL5(1), ITK(3), LCK(4), LCP2(4), MALT1(1), MAP3K14(2), NCK1(1), NCK2(1), NFAT5(2), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), NFKB1(3), NFKB2(2), PAK1(1), PAK6(2), PDCD1(1), PDK1(1), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PPP3R2(2), PRKCQ(4), PTPRC(3), RASGRP1(2), SOS1(1), SOS2(2), TEC(2), VAV1(3), VAV2(2), VAV3(4), ZAP70(3) 9061076 131 47 129 65 81 12 6 21 11 0 0.479 1.000 1.000 335 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 73 AKT2(4), AKT3(2), BTK(4), FCER1A(4), FYN(2), GAB2(1), HRAS(1), IL5(1), INPP5D(7), LCP2(4), LYN(1), MAP2K1(4), MAP2K2(1), MAP2K3(2), MAP2K4(1), MAP2K7(1), MAPK1(3), MAPK10(2), MAPK3(1), MS4A2(4), PDK1(1), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PLA2G1B(1), PLA2G2D(1), PLA2G2F(2), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), PLCG2(6), PRKCA(1), PRKCD(1), RAC1(3), RAF1(2), SOS1(1), SOS2(2), SYK(3), VAV1(3), VAV2(2), VAV3(4) 6536060 113 47 110 53 73 6 5 18 11 0 0.244 1.000 1.000 336 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 94 ADCY1(5), ADCY2(5), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(2), ADCY8(8), ADCY9(1), ATF4(2), CACNA1C(13), CACNA1D(10), CACNA1F(10), CACNA1S(10), CALM1(1), CALML3(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CGA(1), EGFR(6), FSHB(2), GNA11(2), GNAQ(1), GNAS(6), GNRH2(1), HRAS(1), ITPR1(4), ITPR2(8), ITPR3(2), MAP2K1(4), MAP2K2(1), MAP2K3(2), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K4(3), MAPK1(3), MAPK10(2), MAPK3(1), MAPK7(2), MMP14(1), MMP2(1), PLA2G1B(1), PLA2G2D(1), PLA2G2F(2), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), PLCB1(13), PLCB2(4), PLCB4(13), PLD1(2), PLD2(3), PRKACA(1), PRKACG(2), PRKCA(1), PRKCD(1), PRKX(1), RAF1(2), SOS1(1), SOS2(2) 11430804 194 47 189 104 129 14 11 20 20 0 0.135 1.000 1.000 337 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(4), ASH2L(3), CARM1(3), CTCFL(6), DOT1L(1), EHMT1(1), EHMT2(1), EZH2(1), FBXO11(2), HCFC1(7), JMJD4(1), JMJD6(1), KDM6A(1), MLL(9), MLL2(9), MLL3(17), MLL4(7), MLL5(4), NSD1(3), OGT(6), PAXIP1(1), PPP1CB(1), PRDM2(2), PRDM9(11), PRMT1(1), PRMT8(1), SATB1(5), SETD1A(5), SETD2(4), SETD8(1), SETDB1(4), SETMAR(1), STK38(2), SUV420H1(1), SUZ12(1), WHSC1(1), WHSC1L1(1) 10735184 130 46 128 47 86 9 5 17 13 0 0.176 1.000 1.000 338 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 63 ATM(4), CCNA1(3), CCND2(1), CCNE2(3), CCNH(2), CDC25A(3), CDK4(1), CDKN1A(3), CREB3L1(1), CREB3L3(1), E2F1(1), E2F2(2), E2F5(1), GBA2(1), MCM2(2), MCM3(3), MCM4(1), MCM5(1), MDM2(1), MYC(2), MYT1(7), ORC1L(1), ORC2L(1), ORC3L(1), ORC4L(2), ORC6L(1), POLA2(3), POLE(1), POLE2(1), RB1(3), RBL1(3), RPA1(1), TFDP1(1), TFDP2(2), TNXB(29) 7071915 94 46 94 36 57 6 4 17 10 0 0.0864 1.000 1.000 339 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 INPP5A(1), INPP5B(1), INPPL1(4), IPMK(1), ITPK1(2), ITPKB(2), MIOX(2), OCRL(1), PI4KA(6), PI4KB(1), PIK3C3(2), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIP4K2B(1), PIP5K1A(2), PIP5K1B(6), PIP5K1C(2), PLCB1(13), PLCB2(4), PLCB4(13), PLCD3(3), PLCE1(11), PLCG2(6), PLCZ1(6), PTEN(4), SYNJ1(3), SYNJ2(2) 6730061 115 46 110 40 72 9 3 20 11 0 0.00876 1.000 1.000 340 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ABP1(5), ACMSD(5), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), AOC2(2), AOC3(2), AOX1(6), ASMT(2), CAT(2), CYP19A1(2), CYP1A1(3), CYP1A2(2), CYP2A13(3), CYP2A6(5), CYP2A7(2), CYP2B6(5), CYP2C18(5), CYP2C19(17), CYP2C8(8), CYP2C9(9), CYP2E1(1), CYP2F1(1), CYP2J2(1), CYP3A4(4), CYP3A5(3), CYP3A7(3), CYP4B1(7), CYP4F8(4), DDC(2), GCDH(2), HADHA(1), KYNU(2), MAOB(2), TDO2(3), TPH1(2), WARS(1), WARS2(2) 4987511 136 46 135 77 98 8 8 13 9 0 0.267 1.000 1.000 341 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 51 ADORA3(2), CCKBR(5), CCR3(4), CELSR1(6), CELSR2(3), CELSR3(8), CHRM2(6), CHRM3(3), CXCR3(1), EDNRA(2), EMR2(2), EMR3(6), F2R(2), FSHR(3), GHRHR(1), GPR116(9), GPR133(2), GPR143(1), GPR55(1), GPR56(2), GPR61(3), GPR77(1), GPR84(2), GRM1(3), GRPR(1), HRH4(1), LGR6(2), LPHN2(5), LPHN3(7), OR2M4(1), OR8G2(6), P2RY13(2), PTGFR(6), SMO(1), SSTR2(2), TAAR5(3), TSHR(1) 5980532 116 45 115 77 71 14 3 21 7 0 0.550 1.000 1.000 342 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 105 A4GNT(1), ALG10(2), ALG10B(1), ALG13(2), ALG2(2), ALG3(2), ALG8(1), B3GNT7(2), B4GALT4(2), B4GALT5(2), C1GALT1(2), C1GALT1C1(1), CHPF(1), CHST1(1), CHST11(1), CHST12(1), CHST3(1), CHST4(1), CHST6(1), CHSY1(1), DDOST(1), EXT2(1), EXTL1(1), EXTL3(1), FUT11(1), FUT8(1), GALNT1(2), GALNT11(1), GALNT12(3), GALNT13(11), GALNT14(5), GALNT2(4), GALNT3(1), GALNT4(2), GALNT5(2), GALNT6(2), GALNT9(2), GALNTL1(2), GALNTL2(2), GALNTL4(1), GALNTL5(3), GANAB(1), GCNT1(1), HS3ST1(2), HS3ST2(3), HS3ST5(1), HS6ST3(2), MAN1A1(4), MAN1A2(2), MAN1B1(1), MAN1C1(1), MAN2A1(2), MGAT2(2), MGAT3(3), MGAT4A(1), MGAT5(2), NDST2(1), NDST3(5), NDST4(8), OGT(6), RPN2(1), ST3GAL1(2), ST3GAL4(1), STT3B(2), XYLT1(3), XYLT2(1) 9714346 135 45 133 77 72 10 9 27 17 0 0.722 1.000 1.000 343 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(2), ACADL(2), ACADM(2), ACOX3(2), ACSL1(1), ACSL3(2), ACSL5(2), ACSL6(4), ADIPOQ(1), ANGPTL4(3), APOA5(1), AQP7(1), CD36(1), CPT1A(2), CPT1B(3), CPT2(1), CYP4A11(7), CYP4A22(5), CYP7A1(1), CYP8B1(3), FABP1(3), FABP2(2), GK(1), GK2(2), HMGCS2(3), LPL(1), ME1(3), MMP1(4), PCK1(4), PCK2(3), PPARA(2), PPARD(1), PPARG(3), RXRA(1), RXRB(2), SCD(2), SCP2(1), SLC27A1(1), SLC27A2(5), SLC27A5(4), SLC27A6(8), SORBS1(5), UBC(1) 5980718 108 45 107 60 77 8 3 7 13 0 0.459 1.000 1.000 344 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 96 AKT2(4), AKT3(2), CASP8(2), CD14(2), CD40(2), CD80(1), FOS(1), IFNA16(1), IFNA2(1), IFNA21(1), IFNA4(1), IFNA8(1), IFNB1(2), IKBKE(4), IL12A(1), IL1B(2), IL6(1), IRAK1(1), IRAK4(2), IRF3(1), IRF5(1), IRF7(3), LBP(2), MAP2K1(4), MAP2K2(1), MAP2K3(2), MAP2K4(1), MAP2K7(1), MAP3K7(1), MAPK1(3), MAPK10(2), MAPK3(1), MYD88(1), NFKB1(3), NFKB2(2), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), RAC1(3), RELA(2), RIPK1(1), SPP1(3), STAT1(2), TICAM1(3), TLR2(3), TLR3(2), TLR5(4), TLR6(1), TLR7(3), TLR8(5), TLR9(5) 7925160 118 45 117 47 73 6 6 19 14 0 0.0391 1.000 1.000 345 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(17), COL4A2(5), COL4A3(6), COL4A4(20), COL4A5(13), COL4A6(10), F10(2), F11(3), F2(4), F2R(2), F5(7), F8(6), F9(4), FGA(8), FGG(2), KLKB1(6), PROS1(2), SERPINC1(1), SERPING1(3) 4041810 121 45 121 42 84 8 8 12 9 0 0.476 1.000 1.000 346 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 91 ADCY1(5), ADCY2(5), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(2), ADCY8(8), ADCY9(1), AKAP1(1), AKAP11(1), AKAP12(2), AKAP3(2), AKAP6(10), AKAP7(1), AKAP8(2), AKAP9(8), CALM1(1), GNA11(2), GNA12(1), GNA14(3), GNAI3(1), GNAO1(1), GNAQ(1), GNAZ(1), GNB3(2), GNG4(1), HRAS(1), ITPR1(4), KCNJ3(4), PDE1A(7), PDE1B(2), PDE1C(11), PDE4A(3), PDE4B(3), PDE4C(4), PDE4D(1), PDE7B(6), PDE8A(1), PDE8B(2), PRKACA(1), PRKACG(2), PRKAR2B(1), PRKCA(1), PRKCD(1), PRKCG(4), PRKCH(1), PRKCI(1), PRKCQ(4), PRKCZ(2), PRKD3(2), RRAS(1), SLC9A1(2), USP5(2) 10599384 141 44 141 85 96 8 11 12 14 0 0.612 1.000 1.000 347 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 79 AKT2(4), AKT3(2), APAF1(2), ATM(4), BAX(2), BCL2(1), BIRC2(2), BIRC3(1), CAPN1(1), CAPN2(1), CASP3(1), CASP7(3), CASP8(2), CASP9(1), CFLAR(3), CHP(2), CSF2RB(3), CYCS(1), DFFB(1), FAS(2), FASLG(5), IL1A(1), IL1B(2), IL1R1(5), IL3RA(1), IRAK1(1), IRAK2(3), IRAK3(2), IRAK4(2), MAP3K14(2), MYD88(1), NFKB1(3), NFKB2(2), NTRK1(2), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PPP3R2(2), PRKACA(1), PRKACG(2), PRKAR2B(1), RELA(2), RIPK1(1), TNFRSF10D(3), TNFRSF1A(1), TNFSF10(2) 7491548 106 44 105 45 62 9 6 18 11 0 0.193 1.000 1.000 348 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 APH1A(1), CREBBP(6), DLL1(1), DLL3(1), DLL4(3), DTX1(3), DTX2(1), DTX3(1), DTX3L(1), DTX4(1), DVL2(3), EP300(4), JAG1(2), JAG2(1), LFNG(3), MAML2(4), MAML3(2), MFNG(2), NCOR2(8), NCSTN(1), NOTCH1(1), NOTCH2(9), NOTCH3(6), NOTCH4(13), NUMB(2), NUMBL(1), RBPJ(1), RBPJL(1) 6270109 83 44 83 36 39 10 5 21 8 0 0.452 1.000 1.000 349 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 64 AGTR1(4), AGTR2(2), ATP8A1(4), AVPR1B(3), BDKRB2(3), C3AR1(3), CCKAR(4), CCKBR(5), CCR1(5), CCR3(4), CCR4(3), CCR7(1), CCR8(2), CX3CR1(3), CXCR3(1), CXCR4(1), CXCR6(1), EDNRA(2), EDNRB(1), FPR1(5), FSHR(3), GALR1(2), GNB2L1(2), GPR77(1), GRPR(1), LHCGR(7), MC2R(1), MC3R(1), MC4R(1), MC5R(1), NMBR(2), NPY1R(5), NPY2R(3), NPY5R(6), NTSR2(1), OPRK1(3), OPRM1(1), OXTR(2), PPYR1(1), SSTR2(2), SSTR4(3), TACR1(1), TACR2(2), TACR3(4), TRHR(5), TSHR(1) 4618255 119 44 119 85 80 7 11 10 11 0 0.221 1.000 1.000 350 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 39 AGL(3), AMY2B(2), ENPP3(4), G6PC(2), GAA(4), GANAB(1), GBA3(6), GBE1(2), GCK(3), GYS2(5), HK1(1), HK2(1), HK3(2), PYGB(1), PYGL(3), PYGM(3), SI(19), UCHL3(1), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A7(4), UGT1A8(1), UGT2B15(5), UXS1(1) 4758592 79 44 78 57 53 13 4 4 5 0 0.917 1.000 1.000 351 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(2), ADH1C(8), ADH4(2), ADH5(1), ADH7(5), ADHFE1(3), AGK(3), AGPAT2(3), AGPAT4(3), AGPAT6(1), AKR1A1(1), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), CEL(2), DAK(2), DGAT1(1), DGKA(1), DGKB(5), DGKD(2), DGKE(4), DGKG(4), DGKH(2), DGKI(4), DGKQ(2), DGKZ(1), GK(1), GK2(2), GLB1(1), GPAM(1), LCT(6), LIPC(1), LIPF(3), LPL(1), MGLL(3), PNLIP(1), PNLIPRP1(2), PPAP2C(1) 5294322 93 43 91 42 58 6 5 14 10 0 0.169 1.000 1.000 352 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 61 AKT2(4), AKT3(2), BCL10(1), BLNK(2), BTK(4), CARD11(8), CD19(1), CD22(4), CD72(2), CD79B(1), CHP(2), CR2(7), FCGR2B(1), FOS(1), HRAS(1), INPP5D(7), LYN(1), MALT1(1), NFAT5(2), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), NFKB1(3), NFKB2(2), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PLCG2(6), PPP3R2(2), RAC1(3), RASGRP3(4), SYK(3), VAV1(3), VAV2(2), VAV3(4) 6753758 115 43 112 51 66 8 9 16 16 0 0.178 1.000 1.000 353 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(7), ACSL1(1), ACSL3(2), ACSL5(2), ACSL6(4), ADIPOQ(1), ADIPOR1(3), AKT2(4), AKT3(2), CAMKK1(1), CAMKK2(3), CD36(1), CPT1A(2), CPT1B(3), CPT2(1), G6PC(2), G6PC2(1), IRS1(3), IRS2(1), IRS4(2), JAK1(1), JAK2(1), JAK3(2), LEPR(7), MAPK10(2), NFKB1(3), NFKB2(2), PCK1(4), PCK2(3), PPARA(2), PPARGC1A(5), PRKAA2(5), PRKAB2(1), PRKAG1(1), PRKAG2(1), PRKAG3(5), PRKCQ(4), PTPN11(1), RELA(2), RXRA(1), RXRB(2), SLC2A1(1), SLC2A4(1), SOCS3(1), STK11(1), TNFRSF1A(1), TNFRSF1B(2), TYK2(3) 7569072 111 43 110 52 72 10 5 13 11 0 0.180 1.000 1.000 354 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1B(1), ACVRL1(2), BUB1(2), CDKL1(1), CDKL2(1), CDS2(1), CLK1(2), CLK2(2), CSNK2A2(1), DGKA(1), DGKB(5), DGKD(2), DGKE(4), DGKG(4), DGKH(2), DGKQ(2), DGKZ(1), INPP5A(1), INPPL1(4), ITPKB(2), NEK1(1), NEK3(1), OCRL(1), PIK3C2A(3), PIK3C2B(5), PIK3CA(1), PIK3CB(7), PIK3CG(7), PIM2(2), PLCB1(13), PLCB2(4), PLCB4(13), PLCG2(6), PRKACA(1), PRKACG(2), PRKAR2B(1), PRKCA(1), PRKCD(1), PRKCG(4), PRKCH(1), PRKCQ(4), PRKCZ(2), PRKG1(1), RAF1(2), RPS6KA1(3), RPS6KA3(1), RPS6KB1(1), STK11(1) 10019085 131 43 126 74 84 7 2 19 19 0 0.694 1.000 1.000 355 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 AGTR1(4), AGTR2(2), CMA1(1), COL4A1(17), COL4A2(5), COL4A3(6), COL4A4(20), COL4A5(13), COL4A6(10), REN(1) 2297298 79 42 79 27 58 6 3 7 5 0 0.755 1.000 1.000 356 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 68 AKT2(4), AKT3(2), CASP9(1), CHP(2), HRAS(1), KDR(10), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), MAPKAPK2(2), MAPKAPK3(1), NFAT5(2), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), NOS3(2), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PLA2G1B(1), PLA2G2D(1), PLA2G2F(2), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), PLCG2(6), PPP3R2(2), PRKCA(1), PRKCG(4), PTGS2(3), PTK2(3), RAC1(3), RAF1(2), SHC2(2), SPHK2(2), VEGFA(3) 6522889 112 42 109 46 72 6 5 18 11 0 0.0607 1.000 1.000 357 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(5), ADCY2(5), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(2), ADCY8(8), ADCY9(1), CALM1(1), CALML3(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CREB3L1(1), CREB3L2(2), CREB3L3(1), CREBBP(6), CTNNB1(1), DVL2(3), EDNRB(1), EP300(4), FZD1(1), FZD2(1), FZD5(1), FZD7(1), FZD8(1), FZD9(1), GNAI3(1), GNAO1(1), GNAQ(1), GNAS(6), HRAS(1), KIT(2), KITLG(4), LEF1(1), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), MITF(2), PLCB1(13), PLCB2(4), PLCB4(13), PRKACA(1), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(1), RAF1(2), TCF7L1(1), TYRP1(2), WNT10A(2), WNT11(1), WNT3(1), WNT3A(4), WNT4(1), WNT5A(1), WNT5B(1), WNT7A(2), WNT8B(3), WNT9B(1) 9792906 146 42 143 88 93 8 7 19 19 0 0.595 1.000 1.000 358 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(2), CALM1(1), CAMK1G(3), CAMK4(1), CREBBP(6), CSNK1A1(1), ELSPBP1(1), F2(4), FGF2(2), FKBP1A(1), GATA4(1), HAND2(2), HRAS(1), IGF1(2), LIF(2), MAP2K1(4), MAPK1(3), MAPK3(1), MEF2C(1), MYH2(26), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), NKX2-5(1), NPPA(1), PIK3CA(1), PRKACG(2), PRKAR2B(1), RAF1(2), RPS6KB1(1), SYT1(4) 4630879 89 42 87 44 59 10 6 7 7 0 0.357 1.000 1.000 359 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ALPI(2), ALPL(1), ALPP(1), ALPPL2(4), CYP19A1(2), CYP1A1(3), CYP1A2(2), CYP2A13(3), CYP2A6(5), CYP2A7(2), CYP2B6(5), CYP2C18(5), CYP2C19(17), CYP2C8(8), CYP2C9(9), CYP2E1(1), CYP2F1(1), CYP2J2(1), CYP3A4(4), CYP3A5(3), CYP3A7(3), CYP4B1(7), CYP4F8(4), PON1(4) 2647495 98 41 97 59 74 5 5 6 8 0 0.193 1.000 1.000 360 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 63 ACSS2(1), ADH1A(2), ADH1C(8), ADH4(2), ADH5(1), ADH7(5), ADHFE1(3), AKR1A1(1), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B2(1), ALDH7A1(2), ALDOB(2), BPGM(1), DLAT(1), DLD(1), ENO1(1), ENO2(2), ENO3(2), FBP2(1), G6PC(2), G6PC2(1), GALM(1), GAPDH(1), GAPDHS(1), GCK(3), HK1(1), HK2(1), HK3(2), LDHA(2), LDHAL6B(2), PDHA1(1), PDHA2(2), PDHB(1), PGAM2(1), PGK2(5), PKLR(2), PKM2(1) 5232293 73 41 70 41 46 7 7 6 7 0 0.371 1.000 1.000 361 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 46 ACAA1(2), ACADL(2), ACADM(2), ACADS(2), ACADSB(1), ACOX3(2), ACSL1(1), ACSL3(2), ACSL5(2), ACSL6(4), ADH1A(2), ADH1C(8), ADH4(2), ADH5(1), ADH7(5), ADHFE1(3), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), CPT1A(2), CPT1B(3), CPT2(1), CYP4A11(7), CYP4A22(5), DCI(1), GCDH(2), HADHA(1), HADHB(3), HSD17B4(1) 4408867 75 41 72 33 51 5 7 5 7 0 0.141 1.000 1.000 362 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT2(4), AKT3(2), BRAF(3), DAG1(4), DRD2(2), EGFR(6), EPHB2(4), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(2), KCNJ3(4), KCNJ5(2), KCNJ9(2), MAPK1(3), PI3(1), PIK3CB(7), PITX2(2), PLCB1(13), PLCB2(4), PLCB4(13), RAF1(2), SOS1(1), SOS2(2), TERF2IP(1) 5337198 98 41 94 37 62 4 7 13 12 0 0.0232 1.000 1.000 363 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 52 ADH1A(2), ADH1C(8), ADH4(2), ADH7(5), ADHFE1(3), AKR1A1(1), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B2(1), ALDOB(2), BPGM(1), DLAT(1), DLD(1), ENO1(1), ENO2(2), ENO3(2), FBP2(1), G6PC(2), GAPDH(1), GCK(3), HK1(1), HK2(1), HK3(2), LDHA(2), PDHA1(1), PDHA2(2), PDHB(1), PKLR(2), PKM2(1) 4377548 62 40 59 31 41 6 5 5 5 0 0.214 1.000 1.000 364 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 52 ADH1A(2), ADH1C(8), ADH4(2), ADH7(5), ADHFE1(3), AKR1A1(1), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B2(1), ALDOB(2), BPGM(1), DLAT(1), DLD(1), ENO1(1), ENO2(2), ENO3(2), FBP2(1), G6PC(2), GAPDH(1), GCK(3), HK1(1), HK2(1), HK3(2), LDHA(2), PDHA1(1), PDHA2(2), PDHB(1), PKLR(2), PKM2(1) 4377548 62 40 59 31 41 6 5 5 5 0 0.214 1.000 1.000 365 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 CAD(3), CANT1(3), CTPS(1), DCTD(1), DHODH(1), DPYD(15), DPYS(2), ENTPD1(1), ENTPD3(2), ENTPD4(1), ENTPD6(1), ENTPD8(1), NME6(1), NME7(2), NT5C1A(1), NT5C1B(4), NT5C2(1), POLA1(1), POLA2(3), POLD1(2), POLD3(1), POLE(1), POLE2(1), POLR1A(3), POLR1B(1), POLR2A(4), POLR2B(3), POLR2E(1), POLR2F(1), POLR2J(1), POLR2L(1), POLR3A(1), POLR3B(2), PRIM2(3), RRM1(1), TXNRD1(1), UCK1(1), UMPS(1), UPB1(2) 7382847 77 40 76 35 48 4 3 16 6 0 0.275 1.000 1.000 366 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 55 ABP1(5), ADH1A(2), ADH1C(8), ADH4(2), ADH5(1), ADH7(5), ADHFE1(3), ALDH3A1(1), ALDH3B2(1), AOC2(2), AOC3(2), AOX1(6), CARM1(3), COMT(1), DBH(4), DDC(2), FAH(1), GOT2(3), HEMK1(1), HGD(2), HPD(1), LCMT1(1), MAOB(2), METTL2B(2), MYST3(4), MYST4(1), PRMT3(2), PRMT8(1), TAT(5), TH(1), TPO(8), TYRP1(2) 5335032 85 40 83 46 58 6 3 10 8 0 0.450 1.000 1.000 367 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 62 APAF1(2), ATM(4), ATR(4), BAI1(4), BAX(2), CASP3(1), CASP8(2), CASP9(1), CCNB3(7), CCND2(1), CCNE2(3), CCNG1(1), CDK4(1), CDKN1A(3), CYCS(1), EI24(2), FAS(2), GADD45B(2), GTSE1(1), IGF1(2), IGFBP3(2), LRDD(1), MDM2(1), MDM4(1), PTEN(4), RFWD2(1), SERPINB5(2), SESN2(1), SESN3(1), STEAP3(3), THBS1(3), TP73(2), TSC2(6), ZMAT3(1) 5774218 75 40 75 27 39 10 2 9 14 1 0.0950 1.000 1.000 368 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG1(1), ACTG2(3), ACTR2(2), ACTR3(2), FLNA(2), FLNC(10), FSCN1(1), FSCN2(1), FSCN3(2), GDI1(1), GDI2(1), LIMK1(1), MYH2(26), MYLK(11), MYLK2(2), PAK1(1), PAK6(2), ROCK2(2), VASP(1), WASF1(1), WASL(2) 4199906 75 40 72 30 49 12 2 7 5 0 0.0261 1.000 1.000 369 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(2), F11(3), F13B(6), F2(4), F5(7), F7(3), F8(6), F9(4), FGA(8), FGG(2), LPA(14), PLAT(3), PLG(8), SERPINB2(6), SERPINF2(3), VWF(9) 3191410 88 39 88 40 65 4 9 1 9 0 0.273 1.000 1.000 370 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 44 ADH1A(2), ADH1C(8), ADH4(2), ADH7(5), ADHFE1(3), AGPAT2(3), AGPAT4(3), AKR1A1(1), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), CEL(2), DGAT1(1), DGKA(1), DGKB(5), DGKD(2), DGKE(4), DGKG(4), DGKH(2), DGKQ(2), DGKZ(1), GK(1), GLB1(1), LCT(6), LIPC(1), LIPF(3), LPL(1), PNLIP(1), PNLIPRP1(2), PPAP2C(1) 4332390 78 39 76 34 51 3 4 12 8 0 0.143 1.000 1.000 371 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 51 AKR1C4(3), AKR1D1(3), ARSD(1), ARSE(1), CARM1(3), CYP11B1(3), CYP11B2(6), CYP19A1(2), HEMK1(1), HSD11B1(3), HSD11B2(1), HSD17B12(1), HSD17B2(2), HSD17B3(2), HSD17B7(1), HSD3B2(3), LCMT1(1), METTL2B(2), PRMT3(2), PRMT8(1), SRD5A1(1), SRD5A2(1), STS(3), SULT1E1(3), SULT2A1(2), SULT2B1(1), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A7(4), UGT1A8(1), UGT2A1(5), UGT2B10(5), UGT2B11(6), UGT2B15(5), UGT2B7(6) 4257268 90 39 88 48 56 9 9 7 9 0 0.286 1.000 1.000 372 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(3), ALOX12(1), ALOX12B(1), ALOX15(1), ALOX15B(1), ALOX5(2), CYP2B6(5), CYP2C18(5), CYP2C19(17), CYP2C8(8), CYP2C9(9), CYP2E1(1), CYP2J2(1), CYP2U1(1), CYP4A11(7), CYP4A22(5), CYP4F2(2), CYP4F3(6), EPHX2(1), GGT1(1), GPX5(3), GPX6(6), LTA4H(1), PLA2G1B(1), PLA2G2D(1), PLA2G2F(2), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), PTGIS(5), PTGS1(3), PTGS2(3), TBXAS1(2) 3516660 115 39 113 86 87 7 3 9 9 0 0.797 1.000 1.000 373 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(3), ADCY4(1), ADCY6(2), ADCY8(8), CACNA1A(7), CACNA1B(4), GNAS(6), GNAT3(1), GNB3(2), GRM4(3), ITPR3(2), KCNB1(6), PDE1A(7), PLCB2(4), PRKACA(1), PRKACG(2), PRKX(1), SCNN1A(2), SCNN1G(2), TAS1R1(3), TAS1R2(6), TAS2R1(3), TAS2R10(2), TAS2R16(1), TAS2R38(3), TAS2R39(1), TAS2R41(2), TAS2R42(1), TAS2R46(1), TAS2R50(1), TAS2R60(3), TAS2R9(1), TRPM5(4) 5158744 96 39 96 87 60 8 6 9 13 0 0.941 1.000 1.000 374 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(2), BDKRB2(3), CALM1(1), CHRNA1(1), FLT1(9), FLT4(5), KDR(10), NOS3(2), PDE2A(4), PDE3A(8), PDE3B(1), PRKACG(2), PRKAR2B(1), PRKG1(1), PRKG2(3), RYR2(20), SLC7A1(1), SYT1(4) 3713975 78 39 75 52 55 8 2 9 4 0 0.757 1.000 1.000 375 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP4(1), BMP5(8), BMP6(2), BMP7(1), BMP8A(1), CSNK1A1(1), CSNK1A1L(1), CSNK1G3(1), GLI2(9), GLI3(3), HHIP(5), LRP2(25), PRKACA(1), PRKACG(2), PRKX(1), PTCH1(1), PTCH2(4), SHH(1), SMO(1), STK36(4), WNT10A(2), WNT11(1), WNT3(1), WNT3A(4), WNT4(1), WNT5A(1), WNT5B(1), WNT7A(2), WNT8B(3), WNT9B(1) 5494167 91 38 91 44 63 5 5 12 6 0 0.261 1.000 1.000 376 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 BRAF(3), DAXX(3), FOS(1), HRAS(1), MAP2K1(4), MAP2K2(1), MAP2K3(2), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K11(3), MAP3K13(1), MAP3K14(2), MAP3K4(3), MAP3K5(3), MAP3K6(1), MAP3K7(1), MAP3K9(6), MAP4K1(2), MAP4K2(1), MAP4K3(3), MAP4K4(3), MAPK1(3), MAPK10(2), MAPK3(1), MAPK4(4), MAPK6(2), MAPK7(2), MAPKAPK2(2), MAPKAPK3(1), MEF2A(2), MEF2B(1), MEF2C(1), MEF2D(2), MYC(2), NFKB1(3), PAK1(1), RAC1(3), RAF1(2), RELA(2), RIPK1(1), RPS6KA1(3), RPS6KA3(1), RPS6KB1(1), RPS6KB2(2), STAT1(2), TGFB1(1), TGFB3(1) 8617391 95 38 94 44 59 8 3 15 10 0 0.452 1.000 1.000 377 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT2(4), AKT3(2), BCL2(1), BCR(2), BLNK(2), BTK(4), CD19(1), CD22(4), CR2(7), DAG1(4), INPP5D(7), ITPR1(4), ITPR2(8), ITPR3(2), LYN(1), MAP4K1(2), MAPK1(3), MAPK3(1), NFATC1(2), NFATC2(1), NR0B2(1), PDK1(1), PIK3CA(1), PIK3CD(1), PLCG2(6), PPP1R13B(2), PTPRC(3), RAF1(2), SOS1(1), SOS2(2), SYK(3), VAV1(3) 6736858 88 38 87 44 53 8 7 8 12 0 0.255 1.000 1.000 378 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 32 AKT2(4), AKT3(2), BCR(2), BTK(4), CD19(1), ITPR1(4), ITPR2(8), ITPR3(2), LYN(1), NR0B2(1), PDK1(1), PIK3CA(1), PITX2(2), PLCG2(6), PPP1R13B(2), PREX1(1), PTEN(4), PTPRC(3), RPS6KA1(3), RPS6KA3(1), RPS6KB1(1), SAG(2), SYK(3), TEC(2), VAV1(3) 4963778 64 38 63 32 36 5 3 8 12 0 0.259 1.000 1.000 379 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(5), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH4A1(2), AOC2(2), AOC3(2), ASL(3), CKM(1), CKMT2(1), CPS1(4), DAO(1), GAMT(1), GATM(1), GOT2(3), MAOB(2), NOS1(11), NOS3(2), OAT(1), OTC(1), P4HA1(2), P4HA3(2), PYCR1(1) 3996437 58 37 57 42 35 9 2 8 4 0 0.893 1.000 1.000 380 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(2), BLNK(2), FOS(1), HRAS(1), LYN(1), MAP2K1(4), MAP3K1(1), MAPK1(3), MAPK3(1), MAPK8IP3(3), PAPPA(20), RAC1(3), RPS6KA1(3), RPS6KA3(1), SOS1(1), SYK(3), VAV1(3), VAV2(2), VAV3(4) 2903546 59 37 58 31 44 1 1 5 8 0 0.515 1.000 1.000 381 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(4), ABP1(5), ACADL(2), ACADM(2), ACADSB(1), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), AOC2(2), AOC3(2), CNDP1(1), DPYD(15), DPYS(2), GAD1(3), GAD2(1), HADHA(1), UPB1(2) 2649814 53 36 52 29 38 1 5 7 2 0 0.527 1.000 1.000 382 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(3), ALOX15(1), ALOX5(2), CYP1A2(2), CYP2C18(5), CYP2C19(17), CYP2C8(8), CYP2C9(9), CYP2E1(1), CYP2J2(1), CYP3A4(4), CYP3A43(4), CYP3A5(3), CYP3A7(3), HSD3B7(2), PLA2G1B(1), PLA2G2D(1), PLA2G2F(2), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), RDH13(1) 2173287 80 36 79 53 62 2 4 7 5 0 0.584 1.000 1.000 383 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(7), ACACB(7), ACOT12(4), ACSS2(1), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), DLAT(1), DLD(1), GRHPR(1), LDHA(2), LDHAL6B(2), MDH2(1), ME1(3), ME3(1), PC(3), PCK1(4), PCK2(3), PDHA1(1), PDHA2(2), PDHB(1), PKLR(2), PKM2(1) 4269599 56 36 55 32 29 6 8 9 4 0 0.694 1.000 1.000 384 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(8), ATP6V0D2(3), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(3), ATP6V1G3(1), ATP6V1H(1), CASP3(1), EGFR(6), GIT1(2), IGSF5(3), JAM2(2), LYN(1), MAP2K4(1), MAP3K14(2), MAPK10(2), MET(6), NFKB1(3), NFKB2(2), NOD1(2), PAK1(1), PLCG2(6), PTPN11(1), PTPRZ1(5), RAC1(3), RELA(2), TJP1(3) 6414258 77 36 76 39 46 6 7 10 8 0 0.386 1.000 1.000 385 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 ALG2(2), BAX(2), BTK(4), CAD(3), CASP3(1), CASP8(2), CASP8AP2(3), CDK2AP1(1), CSNK1A1(1), DAXX(3), DIABLO(1), EGFR(6), EPHB2(4), FAF1(2), IL1A(1), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K5(3), MAPK1(3), MAPK10(2), MAPK8IP2(2), MAPK8IP3(3), MET(6), NFAT5(2), NFKB1(3), NFKB2(2), NFKBIL2(2), NR0B2(1), PTPN13(6), RALBP1(2), RIPK1(1), SMPD1(1), TPX2(2), TUFM(2) 6544256 82 36 81 32 45 5 7 13 12 0 0.146 1.000 1.000 386 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 72 B2M(1), CD74(2), CD8A(1), CD8B(2), CIITA(5), CTSS(2), HLA-A(2), HLA-B(1), HLA-C(1), HLA-DMA(2), HLA-DOA(1), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(2), HLA-DRA(3), HLA-DRB5(1), HLA-E(1), HLA-F(4), HSPA5(2), IFNA16(1), IFNA2(1), IFNA21(1), IFNA4(1), IFNA8(1), KIR2DL1(2), KIR2DS4(3), KIR3DL1(1), KIR3DL2(2), KIR3DL3(1), KLRC1(1), LGMN(2), NFYA(1), NFYB(1), PSME2(1), RFX5(1), TAP1(1), TAP2(1) 4149079 59 35 59 38 38 5 1 8 7 0 0.750 1.000 1.000 387 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGTR2(2), CALM1(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CDK5(2), F2(4), FYN(2), GNA11(2), HRAS(1), JAK2(1), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), MAPT(3), MYLK(11), PRKCA(1), RAF1(2), SOS1(1), STAT1(2), SYT1(4) 3777088 52 34 50 35 32 4 2 8 6 0 0.879 1.000 1.000 388 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(1), AGPAT2(3), AGPAT4(3), AGPS(1), CDS2(1), CHAT(3), CPT1B(3), DGKA(1), DGKB(5), DGKD(2), DGKE(4), DGKG(4), DGKH(2), DGKQ(2), DGKZ(1), ETNK1(1), GPD1(1), GPD2(1), PAFAH1B1(1), PAFAH2(1), PCYT1B(2), PEMT(1), PLA2G1B(1), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), PLCB2(4), PLCG2(6), PPAP2C(1) 4555382 66 34 65 40 44 3 0 10 9 0 0.577 1.000 1.000 389 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 INPP5A(1), INPPL1(4), ITPKB(2), MIOX(2), OCRL(1), PIK3C2A(3), PIK3C2B(5), PIK3CA(1), PIK3CB(7), PIK3CG(7), PLCB1(13), PLCB2(4), PLCB4(13), PLCG2(6) 3843360 69 34 64 30 43 6 1 10 9 0 0.163 1.000 1.000 390 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 CD36(1), CPT1B(3), CREBBP(6), EP300(4), FABP1(3), HSD17B4(1), LPL(1), MAPK1(3), MAPK3(1), ME1(3), MYC(2), NCOA1(2), NCOR1(1), NCOR2(8), NR0B2(1), NR2F1(2), NRIP1(1), PIK3CA(1), PPARA(2), PRKACG(2), PRKAR2B(1), PRKCA(1), PTGS2(3), RB1(3), RELA(2), RXRA(1), STAT5B(1) 5779170 60 34 60 26 37 6 3 8 6 0 0.349 1.000 1.000 391 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT2(4), AKT3(2), BCR(2), BLNK(2), BTK(4), CD19(1), DAG1(4), EPHB2(4), ITPKB(2), LYN(1), MAP2K1(4), MAP2K2(1), MAPK1(3), NFAT5(2), NFKB1(3), NFKB2(2), NFKBIL2(2), PI3(1), PIK3CA(1), PIK3CD(1), PLCG2(6), PPP1R13B(2), RAF1(2), SOS1(1), SOS2(2), SYK(3), VAV1(3) 4817077 65 34 64 34 35 3 4 12 11 0 0.566 1.000 1.000 392 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(4), AXIN1(2), CCND2(1), CTNNB1(1), DVL2(3), FZD1(1), FZD2(1), FZD5(1), FZD7(1), FZD8(1), FZD9(1), LDLR(2), MAPK10(2), MYC(2), PAFAH1B1(1), PPP2R5C(3), PPP2R5E(1), PRKCA(1), PRKCD(1), PRKCG(4), PRKCH(1), PRKCI(1), PRKCQ(4), PRKCZ(2), RAC1(3), WNT10A(2), WNT11(1), WNT3(1), WNT4(1), WNT5A(1), WNT5B(1), WNT7A(2) 5431840 54 34 54 33 32 5 1 9 7 0 0.718 1.000 1.000 393 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 37 ACAA1(2), ADH1A(2), ADH1C(8), ADH4(2), ADH5(1), ADH7(5), ADHFE1(3), AKR1B10(3), AKR1C4(3), AKR1D1(3), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), BAAT(4), CEL(2), CYP7A1(1), HADHB(3), HSD3B7(2), RDH13(1), SLC27A5(4), SOAT2(2), SRD5A1(1), SRD5A2(1) 2821900 61 33 59 30 39 5 9 4 4 0 0.253 1.000 1.000 394 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(4), ABP1(5), ACADM(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), AOC2(2), AOC3(2), CNDP1(1), DPYD(15), DPYS(2), GAD1(3), GAD2(1), HADHA(1), UPB1(2) 2466121 48 33 47 30 33 2 5 6 2 0 0.745 1.000 1.000 395 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(1), ADRB1(1), ADRB2(1), CHRM2(6), CHRM3(3), CHRM4(2), DRD1(3), DRD2(2), DRD3(3), DRD5(3), HRH1(3), HRH2(2), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(1), HTR1F(2), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(1), HTR5A(7), HTR7(2) 2294191 55 33 54 52 36 2 2 6 9 0 0.700 1.000 1.000 396 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(7), ADH5(1), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), DLAT(1), DLD(1), GRHPR(1), LDHA(2), MDH2(1), ME1(3), ME3(1), PC(3), PCK1(4), PDHA1(1), PDHA2(2), PDHB(1), PKLR(2), PKM2(1) 3375888 42 33 41 28 26 2 6 5 3 0 0.862 1.000 1.000 397 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(10), CDR1(2), DGKI(4), IL6ST(2), PIGK(3), RPL10(2), RPL11(1), RPL18(2), RPL27(1), RPL3(1), RPL39(1), RPL4(2), RPL7(1), RPS13(1), RPS15(1), RPS2(1), RPS20(1), RPS6(1), RPS6KA1(3), RPS6KA3(1), RPS6KA6(4), RPS6KB1(1), RPS6KB2(2), SLC36A2(1), TBC1D10C(1), TSPAN9(1), UBC(1) 4717605 52 33 51 27 32 4 2 9 5 0 0.488 1.000 1.000 398 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 43 CBL(3), CD3D(1), CTLA4(2), DAG1(4), EPHB2(4), FBXW7(1), GRAP2(2), ITK(3), ITPKB(2), LCK(4), LCP2(4), MAPK1(3), NCK1(1), NFAT5(2), NFKB1(3), NFKB2(2), NFKBIL2(2), PAK1(1), PAK6(2), PTPRC(3), RAF1(2), RASGRP1(2), RASGRP2(1), RASGRP3(4), RASGRP4(1), SOS1(1), SOS2(2), VAV1(3), ZAP70(3) 4918318 68 33 68 35 37 6 4 10 11 0 0.507 1.000 1.000 399 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 31 ABP1(5), ADH1A(2), ADH1C(8), ADH4(2), ADH7(5), ADHFE1(3), ALDH3A1(1), ALDH3B2(1), AOC2(2), AOC3(2), AOX1(6), COMT(1), DBH(4), DDC(2), FAH(1), GOT2(3), HGD(2), HPD(1), MAOB(2), TAT(5), TH(1), TPO(8) 2803860 67 33 65 36 48 6 3 4 6 0 0.253 1.000 1.000 400 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 12 C1R(3), C1S(1), C2(3), C3(11), C5(3), C6(14), C7(11), C8A(9), C8B(9), MASP1(4) 1766082 68 32 65 32 48 5 3 4 8 0 0.190 1.000 1.000 401 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(4), CALM1(1), FCER1A(4), FOS(1), HRAS(1), LYN(1), MAP2K1(4), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAPK1(3), MAPK3(1), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), PIK3CA(1), PLA2G4A(2), RAF1(2), SOS1(1), SYK(3), SYT1(4), VAV1(3) 3908366 50 32 49 30 31 2 4 5 8 0 0.885 1.000 1.000 402 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(5), AGXT(1), AGXT2(7), AOC2(2), AOC3(2), CBS(4), CHDH(1), CPT1B(3), DAO(1), DLD(1), DMGDH(2), GAMT(1), GATM(1), GCAT(1), GLDC(1), MAOB(2), PEMT(1), PLCB2(4), PLCG2(6), PSPH(1), SARDH(4), SARS(1), SHMT2(1) 3827023 53 32 52 42 37 2 2 4 8 0 0.901 1.000 1.000 403 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), ABP1(5), ACMSD(5), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), AOC2(2), AOC3(2), AOX1(6), ASMT(2), CARM1(3), CAT(2), CYP1A1(3), CYP1A2(2), DDC(2), GCDH(2), HADHA(1), HEMK1(1), HSD17B4(1), INMT(1), KYNU(2), LCMT1(1), LNX1(4), MAOB(2), METTL2B(2), NFX1(2), OGDH(2), OGDHL(9), PRMT3(2), PRMT8(1), TDO2(3), TPH1(2), TPH2(1), WARS(1), WARS2(2) 5508920 85 32 85 36 53 7 4 14 7 0 0.121 1.000 1.000 404 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(1), AGPAT2(3), AGPAT4(3), AGPAT6(1), CDS2(1), CHAT(3), CHPT1(1), DGKA(1), DGKB(5), DGKD(2), DGKE(4), DGKG(4), DGKH(2), DGKI(4), DGKQ(2), DGKZ(1), ETNK1(1), GPAM(1), GPD1(1), GPD2(1), MYST3(4), MYST4(1), PCYT1B(2), PEMT(1), PLA2G1B(1), PLA2G2D(1), PLA2G2F(2), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), PLD1(2), PLD2(3), PPAP2C(1) 5950831 70 32 70 46 42 4 2 12 10 0 0.883 1.000 1.000 405 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(3), CANT1(3), CTPS(1), DCTD(1), DHODH(1), DPYD(15), DPYS(2), ENTPD1(1), POLD1(2), POLE(1), POLG(1), POLL(1), POLQ(5), POLR1B(1), POLR2A(4), POLR2B(3), POLR2E(1), POLR2F(1), POLR2J(1), POLR2L(1), POLRMT(1), RRM1(1), TXNRD1(1), UCK1(1), UMPS(1), UPB1(2) 5227756 56 32 55 26 34 6 3 9 4 0 0.286 1.000 1.000 406 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CDK5(2), CHN1(2), LIMK1(1), MAP3K1(1), MYL2(3), MYLK(11), NCF2(2), PAK1(1), PDGFRA(7), PIK3CA(1), PLD1(2), RAC1(3), RALBP1(2), RPS6KB1(1), TRIO(4), VAV1(3), WASF1(1) 3187615 47 32 45 29 29 3 2 8 5 0 0.832 1.000 1.000 407 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT2(4), AKT3(2), ARHGEF11(3), BCL2(1), LPA(14), MAP2K4(1), MAP3K1(1), MAP3K5(3), NFKB1(3), NFKB2(2), NFKBIL2(2), PDK1(1), PHKA2(4), PI3(1), PIK3CB(7), PLD1(2), PLD2(3), PTK2(3), ROCK2(2), SRF(1) 4466232 60 32 59 26 31 5 3 12 9 0 0.402 1.000 1.000 408 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(1), CD3D(1), CD3G(1), FOS(1), FYN(2), HRAS(1), LCK(4), MAP2K1(4), MAP2K4(1), MAP3K1(1), MAPK3(1), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), NFKB1(3), PIK3CA(1), PRKCA(1), RAC1(3), RAF1(2), RASA1(3), RELA(2), SOS1(1), SYT1(4), VAV1(3), ZAP70(3) 4343990 55 32 54 29 33 6 3 8 5 0 0.758 1.000 1.000 409 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 13 C1R(3), C1S(1), C2(3), C3(11), C5(3), C6(14), C7(11), C8A(9), MASP1(4), MASP2(3), MBL2(2) 1812945 64 31 61 29 47 4 2 3 8 0 0.140 1.000 1.000 410 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(2), DLAT(1), DLD(1), ENO1(1), ENO2(2), ENO3(2), FBP2(1), G6PC(2), GAPDH(1), GAPDHS(1), GCK(3), GOT2(3), HK1(1), HK2(1), HK3(2), LDHA(2), LDHAL6B(2), MDH2(1), PC(3), PCK1(4), PDHA1(1), PDHA2(2), PDHB(1), PDHX(1), PGAM2(1), PGK2(5), PKLR(2), PKM2(1) 3877936 50 31 49 32 29 6 5 3 7 0 0.566 1.000 1.000 411 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(2), AARS2(2), ABAT(4), ACY3(1), ADSSL1(1), AGXT(1), AGXT2(7), ASL(3), ASNS(1), ASPA(3), ASRGL1(1), ASS1(2), CAD(3), CRAT(2), DARS(4), DARS2(1), DLAT(1), DLD(1), GAD1(3), GAD2(1), GOT2(3), NARS2(1), PC(3), PDHA1(1), PDHA2(2), PDHB(1) 3458646 55 31 53 23 39 5 5 3 3 0 0.0985 1.000 1.000 412 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(5), AGXT(1), AGXT2(7), AKR1B10(3), AOC2(2), AOC3(2), CBS(4), CHDH(1), DAO(1), DLD(1), DMGDH(2), GAMT(1), GATM(1), GCAT(1), GLDC(1), HSD3B7(2), MAOB(2), PEMT(1), PHGDH(3), PSPH(1), RDH13(1), SARDH(4), SARS(1), SHMT2(1), TARS2(2) 3890357 51 31 51 42 34 2 3 5 7 0 0.956 1.000 1.000 413 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(4), ACAA1(2), ACADM(2), ACADS(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), ALDH7A1(2), AOX1(6), AUH(1), BCAT1(1), BCKDHA(1), DLD(1), HADHA(1), HADHB(3), HIBADH(2), HMGCL(1), HMGCS2(3), HSD17B4(1), MCCC1(2), MCCC2(1), MUT(1), OXCT1(1), PCCB(1) 3937087 46 31 46 21 25 6 6 6 3 0 0.423 1.000 1.000 414 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 38 ALAD(1), BLVRA(1), COX10(3), CP(2), EPRS(2), FECH(3), FTH1(2), FTMT(1), HMOX2(1), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A7(4), UGT1A8(1), UGT2A1(5), UGT2B10(5), UGT2B11(6), UGT2B15(5), UGT2B7(6) 3556061 53 31 52 31 29 6 7 3 8 0 0.640 1.000 1.000 415 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), GRIN1(2), GRIN2A(15), GRIN2B(11), GRIN2C(1), GRIN2D(3), NOS1(11), PRKACG(2), PRKAR2B(1), PRKCA(1), SYT1(4) 2318534 52 31 50 47 37 7 0 5 3 0 0.959 1.000 1.000 416 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(4), BMPR1B(2), CCND2(1), CDK4(1), DMC1(3), EGR1(2), ESR2(3), FSHR(3), GJA4(2), INHA(1), LHCGR(7), MSH5(2), NCOR1(1), NR5A1(1), NRIP1(1), PGR(3), PRLR(5), PTGER2(1), SMPD1(1) 3173163 44 31 43 33 33 2 0 5 4 0 0.961 1.000 1.000 417 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(2), ACADL(2), ACADM(2), ACADS(2), ACADSB(1), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), AOX1(6), BCAT1(1), BCKDHA(1), HADHA(1), HADHB(3), HIBADH(2), HMGCL(1), MCCC1(2), MCCC2(1), MUT(1), OXCT1(1), PCCB(1) 3296518 41 31 41 18 24 4 6 5 2 0 0.379 1.000 1.000 418 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(15), GABBR1(1), GPRC5A(3), GRM1(3), GRM2(2), GRM3(13), GRM4(3), GRM5(3), GRM7(10), GRM8(4) 1904706 57 30 56 38 39 3 6 6 3 0 0.369 1.000 1.000 419 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(5), ALDH3A1(1), ALDH3B2(1), AOC2(2), AOC3(2), DDC(2), EPX(2), GOT2(3), HPD(1), LPO(2), MAOB(2), MPO(1), MYST3(4), MYST4(1), PRDX6(2), TAT(5), TPO(8) 3117884 44 30 44 31 29 5 3 2 5 0 0.802 1.000 1.000 420 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(2), ACTN1(1), ACTN2(3), ACTN3(2), BCAR1(1), BCR(2), CAPN1(1), FYN(2), HRAS(1), ITGA1(4), ITGB1(1), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), PTK2(3), RAF1(2), RAP1A(1), SOS1(1), TLN1(4), VCL(3), ZYX(1) 4254700 44 30 44 24 23 2 4 7 8 0 0.590 1.000 1.000 421 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(2), DOCK1(5), FOS(1), HGF(7), HRAS(1), ITGA1(4), ITGB1(1), MAP2K1(4), MAP2K2(1), MAP4K1(2), MAPK1(3), MAPK3(1), MET(6), PAK1(1), PIK3CA(1), PTEN(4), PTK2(3), PTPN11(1), RAF1(2), RAP1A(1), RAP1B(1), RASA1(3), SOS1(1) 3985619 56 30 56 25 31 4 2 7 12 0 0.534 1.000 1.000 422 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT2(4), AKT3(2), BRD4(3), CBL(3), F2RL2(1), INPPL1(4), IRS1(3), IRS2(1), IRS4(2), LNPEP(3), MAPK1(3), MAPK3(1), PARD3(3), PDK1(1), PIK3CA(1), PIK3CD(1), PPYR1(1), PTEN(4), PTPN1(3), RAF1(2), RPS6KA1(3), RPS6KA3(1), RPS6KB1(1), SERPINB6(2), SLC2A4(1), SORBS1(5), SOS1(1), SOS2(2) 5384579 62 30 62 27 30 7 3 11 11 0 0.392 1.000 1.000 423 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGTR1(4), CALM1(1), EGFR(6), GNAQ(1), HRAS(1), MAP2K1(4), MAP2K2(1), MAP2K4(1), MAP3K1(1), MAPK1(3), MAPK3(1), MEF2A(2), MEF2B(1), MEF2C(1), MEF2D(2), PAK1(1), PRKCA(1), PTK2(3), RAC1(3), RAF1(2), SOS1(1), SYT1(4) 3043906 45 29 44 21 30 1 3 3 8 0 0.525 1.000 1.000 424 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 112 ATP12A(3), ATP4A(6), ATP4B(1), ATP5F1(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(8), ATP6V0D2(3), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(3), ATP6V1G3(1), ATP6V1H(1), COX10(3), COX4I2(4), COX5B(1), COX6A1(1), LHPP(1), NDUFA10(1), NDUFA6(1), NDUFB2(1), NDUFB5(1), NDUFS3(1), NDUFS4(1), NDUFS6(1), SDHC(1), UQCRC2(1) 5089622 52 29 52 22 25 8 5 7 7 0 0.190 1.000 1.000 425 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(1), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), CYP2C19(17), CYP2C9(9), DHRS2(2), DHRS3(1), DHRSX(1), HADHA(1), MYST3(4), MYST4(1) 2827270 45 29 44 31 27 3 5 4 6 0 0.880 1.000 1.000 426 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(6), ESR1(1), ESR2(3), HNF4A(1), NR1D2(3), NR1H2(1), NR1I3(1), NR2E1(2), NR2F1(2), NR2F2(1), NR3C1(2), NR4A2(1), NR5A1(1), NR5A2(3), PGR(3), PPARA(2), PPARD(1), PPARG(3), RARB(1), RORA(1), RORC(1), RXRA(1), RXRB(2), THRA(1), THRB(4) 3792976 48 29 48 33 35 6 0 3 4 0 0.832 1.000 1.000 427 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(5), ACY3(1), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B2(1), ALDH7A1(2), AOC2(2), AOC3(2), ASPA(3), CARM1(3), CNDP1(1), DDC(2), HAL(3), HARS(3), HDC(5), HEMK1(1), LCMT1(1), MAOB(2), METTL2B(2), PRMT3(2), PRMT8(1), UROC1(2) 3595638 50 28 50 34 30 4 5 5 6 0 0.779 1.000 1.000 428 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(1), ARSE(1), CERK(1), GAL3ST1(1), GBA(1), GLB1(1), LCT(6), NEU2(2), NEU3(1), NEU4(4), PPAP2C(1), SGMS1(4), SGPP2(3), SMPD1(1), SMPD3(2), SPHK2(2), SPTLC2(2), UGT8(1) 3228152 35 28 35 30 24 1 2 5 3 0 0.947 1.000 1.000 429 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AADAC(4), ABAT(4), ACADS(2), ACSM1(6), AKR1B10(3), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH5A1(2), ALDH7A1(2), BDH1(1), DDHD1(2), GAD1(3), GAD2(1), HADHA(1), HMGCL(1), HMGCS2(3), HSD17B4(1), HSD3B7(2), ILVBL(2), OXCT1(1), PDHA1(1), PDHA2(2), PDHB(1), PLA1A(2), PRDX6(2), RDH13(1) 3705372 56 28 55 32 36 5 6 4 5 0 0.591 1.000 1.000 430 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(2), AARS2(2), CARS(1), CARS2(1), DARS(4), DARS2(1), EPRS(2), FARS2(2), FARSA(1), FARSB(1), HARS(3), IARS2(5), LARS(2), LARS2(2), NARS2(1), QARS(2), SARS(1), TARS2(2), VARS(7), VARS2(1), WARS(1), WARS2(2) 4990522 46 28 44 23 26 4 3 6 7 0 0.535 1.000 1.000 431 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(1), DAXX(3), EGF(4), EGFR(6), ETS1(1), ETS2(3), FOS(1), HRAS(1), MAP2K1(4), MAP2K3(2), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K14(2), MAP3K5(3), MAPK1(3), MAPK3(1), NFKB1(3), PPP2CA(1), PRKCA(1), PRKCD(1), PRKCG(4), PRKCH(1), PRKCQ(4), RAF1(2), RELA(2), RIPK1(1), TNFRSF1A(1), TNFRSF1B(2) 4457402 61 28 61 31 36 6 3 9 7 0 0.581 1.000 1.000 432 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(5), ALDH3A1(1), ALDH3B2(1), AOC2(2), AOC3(2), DDC(2), EPX(2), GOT2(3), HPD(1), LPO(2), MAOB(2), MPO(1), PRDX2(2), PRDX6(2), TAT(5), TPO(8) 1992954 41 28 41 26 28 5 3 1 4 0 0.427 1.000 1.000 433 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 21 BTK(4), EPHB2(4), F2(4), F2RL2(1), F2RL3(1), MAPK1(3), MAPK7(2), PLD1(2), PLD2(3), PTK2(3), RAF1(2), RASAL1(6), TEC(2), VAV1(3) 2416920 40 28 40 27 20 6 1 7 6 0 0.823 1.000 1.000 434 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 29 AKR1C4(3), AKR1D1(3), ARSD(1), ARSE(1), CYP11B1(3), CYP11B2(6), HSD11B1(3), HSD11B2(1), HSD17B2(2), HSD17B3(2), HSD3B2(3), SRD5A1(1), SRD5A2(1), STS(3), SULT1E1(3), SULT2A1(2), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A7(4), UGT1A8(1), UGT2B15(5) 2378002 53 27 52 34 37 6 5 1 4 0 0.558 1.000 1.000 435 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(2), BTK(4), CALM1(1), CD79B(1), FOS(1), HRAS(1), LYN(1), MAP2K1(4), MAP3K1(1), MAPK3(1), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), PRKCA(1), RAC1(3), RAF1(2), SOS1(1), SYK(3), SYT1(4), VAV1(3) 3481500 45 27 44 28 28 1 5 4 7 0 0.888 1.000 1.000 436 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10(2), ALG10B(1), ALG13(2), ALG2(2), ALG3(2), ALG5(1), ALG8(1), DDOST(1), DOLPP1(1), FUT8(1), GANAB(1), MAN1A1(4), MAN1A2(2), MAN1B1(1), MAN1C1(1), MAN2A1(2), MGAT2(2), MGAT3(3), MGAT4A(1), MGAT5(2), RFT1(1), RPN2(1), STT3B(2) 3859166 37 27 37 27 17 3 6 6 5 0 0.893 1.000 1.000 437 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(8), AGTR1(4), AGTR2(2), ANPEP(3), CMA1(1), CPA3(5), CTSA(1), ENPEP(8), LNPEP(3), MME(5), REN(1), THOP1(1) 1918333 42 27 41 29 30 2 3 0 7 0 0.657 1.000 1.000 438 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADRBK2(1), ARRB2(2), CALM1(1), CALML3(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CLCA1(1), CLCA4(4), CNGA3(4), CNGA4(4), CNGB1(4), GUCA1A(1), GUCA1B(1), GUCA1C(1), PDE1C(11), PRKACA(1), PRKACG(2), PRKG1(1), PRKG2(3), PRKX(1) 2749888 48 27 46 32 33 1 2 9 3 0 0.765 1.000 1.000 439 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ACTG2(3), ADCY9(1), ARL4D(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(8), ATP6V0D2(3), ATP6V1A(1), ATP6V1C2(3), ATP6V1G3(1), ATP6V1H(1), ERO1L(2), GNAS(6), PLCG2(6), PRKCA(1), SEC61A1(2) 3380926 43 27 42 20 27 3 3 5 5 0 0.192 1.000 1.000 440 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(4), ACACA(7), ACADL(2), ACADM(2), ACADSB(1), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), HADHA(1), LDHA(2), MUT(1), PCCB(1), SUCLG1(1) 3031698 33 27 33 18 19 0 7 6 1 0 0.712 1.000 1.000 441 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(3), ALOX12(1), ALOX15(1), ALOX5(2), CYP4F2(2), CYP4F3(6), EPX(2), GGT1(1), LPO(2), LTA4H(1), MPO(1), PLA2G1B(1), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), PRDX2(2), PRDX6(2), PTGIS(5), PTGS1(3), PTGS2(3), TBXAS1(2), TPO(8) 2540980 58 27 58 34 40 7 1 7 3 0 0.338 1.000 1.000 442 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(4), EIF2B1(1), EIF2B2(1), EIF2B5(1), FLT1(9), FLT4(5), HIF1A(2), HRAS(1), KDR(10), NOS3(2), PIK3CA(1), PRKCA(1), PTK2(3), VHL(1) 3106456 42 27 41 24 22 5 1 5 9 0 0.728 1.000 1.000 443 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(5), CALM1(1), FOS(1), GNAQ(1), GNAS(6), HRAS(1), MAP2K1(4), MAPK3(1), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), PRKACG(2), PRKAR2B(1), PRKCA(1), RAF1(2), RPS6KA3(1), SYT1(4) 3160214 42 26 41 26 29 2 3 2 6 0 0.765 1.000 1.000 444 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 22 UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A7(4), UGT1A8(1), UGT2A1(5), UGT2B10(5), UGT2B11(6), UGT2B15(5), UGT2B7(6) 2197532 37 26 36 27 20 5 5 2 5 0 0.877 1.000 1.000 445 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AKR1B10(3), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), BBOX1(1), DOT1L(1), EHMT1(1), EHMT2(1), GCDH(2), HADHA(1), HSD17B4(1), HSD3B7(2), NSD1(3), OGDH(2), OGDHL(9), PLOD1(1), PLOD2(1), RDH13(1), SETD1A(5), SETDB1(4), SHMT2(1) 5262983 49 26 49 23 30 5 5 5 4 0 0.377 1.000 1.000 446 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(4), ACACA(7), ACACB(7), ACADM(2), ACSS2(1), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), ALDH7A1(2), HADHA(1), LDHA(2), LDHAL6B(2), MUT(1), PCCB(1), SUCLG1(1) 3632300 38 26 38 20 17 4 8 7 2 0 0.652 1.000 1.000 447 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(2), BTG1(2), CRY1(1), EIF4G2(1), ETV6(4), GSTP1(1), HSPA8(2), MYF6(3), NCKAP1(2), NCOA4(3), NR1D2(3), PER1(3), PER2(1), PIGF(1), PPP2CB(1), TOB1(1), VAPA(1), ZFR(1) 3326605 33 25 33 17 16 3 3 7 4 0 0.828 1.000 1.000 448 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(2), F2(4), F2R(2), F5(7), F7(3), FGA(8), FGG(2), PROS1(2), SERPINC1(1), TFPI(4) 1499136 35 25 35 15 19 5 4 2 5 0 0.396 1.000 1.000 449 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 19 CALCR(4), CALCRL(4), CD97(1), CRHR1(2), ELTD1(8), EMR1(2), EMR2(2), GHRHR(1), GLP1R(3), GLP2R(4), GPR64(2), LPHN1(1), LPHN2(5), LPHN3(7), SCTR(1), VIPR1(1), VIPR2(2) 2312502 50 25 48 32 34 3 4 3 6 0 0.491 1.000 1.000 450 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(5), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B2(1), AOC2(2), AOC3(2), ASPA(3), CNDP1(1), DDC(2), HAL(3), HARS(3), HDC(5), MAOB(2) 2207941 39 25 39 23 28 1 4 2 4 0 0.485 1.000 1.000 451 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(5), ACY1(1), ADC(1), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), AOC2(2), AOC3(2), ASL(3), ASS1(2), CPS1(4), GATM(1), MAOB(2), NAGS(1), OTC(1) 2655672 33 25 33 24 22 3 3 2 3 0 0.824 1.000 1.000 452 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(2), ASL(3), ASS1(2), CKM(1), CKMT2(1), CPS1(4), DAO(1), EPRS(2), GAMT(1), GATM(1), GOT2(3), LAP3(1), NOS1(11), NOS3(2), OAT(1), OTC(1), P4HA1(2), P4HA3(2), PYCR1(1) 3255679 42 25 41 29 23 8 0 7 4 0 0.864 1.000 1.000 453 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), DPYD(15), DPYS(2), ENPP3(4), ILVBL(2), PANK1(1), PANK4(1), UPB1(2), VNN1(1) 1579004 29 25 28 14 18 3 1 5 2 0 0.473 1.000 1.000 454 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 FUCA1(1), GALNS(1), GBA(1), GLB1(1), HEXA(1), HEXB(1), HGSNAT(1), HPSE(3), HPSE2(1), HYAL1(2), IDS(1), IDUA(1), LCT(6), MAN2B1(2), MAN2B2(3), NEU2(2), NEU3(1), NEU4(4), SPAM1(5) 3111131 38 25 38 25 27 3 0 4 4 0 0.739 1.000 1.000 455 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(6), EP300(4), IL1B(2), MAP2K3(2), MAP3K14(2), MAP3K7(1), MYD88(1), NFKB1(3), NR3C1(2), RELA(2), TGFBR2(3), TLR2(3) 2710429 31 25 31 13 17 5 2 5 2 0 0.500 1.000 1.000 456 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 32 AKT2(4), AKT3(2), BTK(4), INPP5D(7), PDK1(1), PIK3CA(1), PPP1R13B(2), PTEN(4), RPS6KA1(3), RPS6KA3(1), RPS6KB1(1), SOS1(1), SOS2(2), TEC(2) 3229971 35 25 35 16 16 4 3 6 6 0 0.564 1.000 1.000 457 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 31 APAF1(2), BCL2(1), BIRC2(2), BIRC3(1), CASP3(1), CASP7(3), CASP8(2), CASP9(1), CFLAR(3), CYCS(1), DFFB(1), MAP3K14(2), NFKB1(3), RELA(2), RIPK1(1), SPTAN1(1), TNFRSF25(1), TNFSF10(2) 2992514 30 24 30 14 12 4 3 7 4 0 0.598 1.000 1.000 458 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), DIAPH2(1), MCM10(2), MCM2(2), MCM3(3), MCM4(1), MCM5(1), ORC1L(1), ORC2L(1), ORC3L(1), ORC4L(2), ORC6L(1), POLA2(3), POLD1(2), POLD3(1), POLE(1), POLE2(1), RPA1(1), RPA4(1), UBC(1) 4610390 28 24 28 18 17 1 1 6 3 0 0.856 1.000 1.000 459 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B10(3), ALDOB(2), FBP2(1), FPGT(1), FUK(2), HK1(1), HK2(1), HK3(2), HSD3B7(2), LHPP(1), MPI(1), MTMR1(2), PFKFB1(1), PFKFB2(2), PFKFB4(1), PGM2(2), PMM1(2), PMM2(1), RDH13(1), SORD(2) 3371685 31 24 31 26 18 5 4 2 2 0 0.858 1.000 1.000 460 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(2), ALPL(1), ALPP(1), ALPPL2(4), ASCC3(1), DDX18(1), DDX19A(1), DDX23(1), DDX4(2), DDX41(1), DDX50(2), DDX51(2), DDX52(1), DHX58(1), EP400(6), FPGS(1), IFIH1(2), MOV10L1(5), QDPR(1), RUVBL2(1), SETX(3), SKIV2L2(1), SMARCA2(4), SMARCA5(1) 5682795 46 24 46 23 29 1 3 8 5 0 0.484 1.000 1.000 461 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(4), ABP1(5), AOC2(2), AOC3(2), CES1(5), CES7(6), DDHD1(2), MYST3(4), MYST4(1), PLA1A(2), PRDX6(2) 2313120 35 24 34 16 24 1 2 2 6 0 0.421 1.000 1.000 462 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(3), ANAPC10(1), ANAPC2(2), ANAPC4(2), ANAPC7(1), CDC16(1), CDC27(5), CUL1(1), CUL3(2), FBXW7(1), FZR1(2), ITCH(1), SKP2(1), SMURF1(1), SMURF2(3), UBA1(1), UBE2D3(1), UBE2E2(2), UBE2E3(1), VHL(1), WWP1(1), WWP2(1) 3633636 35 24 35 13 18 2 4 3 7 1 0.402 1.000 1.000 463 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 BCL2(1), CBL(3), CFLAR(3), E2F1(1), FOS(1), HRAS(1), IL2RA(1), IL2RG(1), IRS1(3), JAK1(1), JAK3(2), MAPK1(3), MAPK3(1), MYC(2), PIK3CA(1), PPIA(1), RAF1(2), RPS6KB1(1), SOCS3(1), SOS1(1), STAT5B(1), SYK(3) 3282894 35 24 35 18 15 4 5 6 5 0 0.734 1.000 1.000 464 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(2), ADCY1(5), CDC25C(2), GNAS(6), HRAS(1), MAPK1(3), MAPK3(1), MYT1(7), PRKACG(2), PRKAR2B(1), RPS6KA1(3) 1868491 33 24 33 19 25 1 0 2 5 0 0.454 1.000 1.000 465 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), DPYD(15), DPYS(2), ENPP3(4), PANK1(1), PANK4(1), UPB1(2) 1272385 26 24 25 13 17 3 1 4 1 0 0.572 1.000 1.000 466 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(5), F2(4), F2R(2), F2RL3(1), GNA12(1), GNAQ(1), MAP3K7(1), PIK3CA(1), PLCB1(13), PRKCA(1) 2356180 30 24 29 21 21 3 0 2 4 0 0.806 1.000 1.000 467 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 30 CD14(2), FOS(1), IRAK1(1), MAP2K3(2), MAP2K4(1), MAP3K1(1), MAP3K14(2), MAP3K7(1), MYD88(1), NFKB1(3), PPARA(2), RELA(2), TLR10(3), TLR2(3), TLR3(2), TLR6(1), TLR7(3), TLR9(5) 3149340 36 24 36 21 21 3 2 5 5 0 0.759 1.000 1.000 468 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(5), CD3D(1), CD3G(1), CREBBP(6), GNAS(6), HLA-DRA(3), LCK(4), PRKACG(2), PRKAR2B(1), PTPRC(3), ZAP70(3) 2065365 35 23 35 26 23 3 1 3 5 0 0.889 1.000 1.000 469 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(5), CD3D(1), CD3G(1), CREBBP(6), GNAS(6), HLA-DRA(3), LCK(4), PRKACG(2), PRKAR2B(1), PTPRC(3), ZAP70(3) 2065365 35 23 35 26 23 3 1 3 5 0 0.889 1.000 1.000 470 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GHR(4), HRAS(1), INSR(2), IRS1(3), JAK2(1), MAP2K1(4), MAPK1(3), MAPK3(1), PIK3CA(1), PRKCA(1), RAF1(2), RPS6KA1(3), SLC2A4(1), SOS1(1), SRF(1), STAT5B(1) 3022929 30 23 30 27 14 3 1 6 6 0 0.997 1.000 1.000 471 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(4), ADC(1), ALDH4A1(2), ALDH5A1(2), CAD(3), CPS1(4), EPRS(2), GAD1(3), GAD2(1), GCLC(2), GFPT2(1), GMPS(1), GOT2(3), GSS(1), NADSYN1(1), QARS(2) 3606109 33 23 33 20 18 4 3 5 3 0 0.720 1.000 1.000 472 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IFNB1(2), IL1A(1), IL1B(2), IL1R1(5), IL1RN(2), IL6(1), IRAK1(1), IRAK2(3), IRAK3(2), MAP2K3(2), MAP3K1(1), MAP3K14(2), MAP3K7(1), MYD88(1), NFKB1(3), RELA(2), TGFB1(1), TGFB3(1) 2682743 33 23 33 15 21 4 2 4 2 0 0.373 1.000 1.000 473 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(3), ATP4B(1), ATP6V0A1(2), ATP6V0A4(8), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(3), ATP6V1G3(1), ATP6V1H(1), ATP7A(1), ATP7B(5), COX10(3), COX5B(1), COX6A1(1), NDUFA10(1), NDUFB2(1), NDUFB5(1) 3497533 36 23 36 28 16 5 6 3 6 0 0.947 1.000 1.000 474 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(4), AXIN1(2), CREBBP(6), CTNNB1(1), EP300(4), FZD1(1), LDB1(1), LEF1(1), PITX2(2), TRRAP(9) 3028446 31 23 29 15 16 2 4 4 5 0 0.654 1.000 1.000 475 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(1), BRAF(3), CREB5(2), DUSP9(1), EEF2K(3), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), NFKB1(3), RAP1A(1), RPS6KA1(3), RPS6KA3(1), SOS1(1), SOS2(2) 2682994 30 23 30 12 19 0 2 5 4 0 0.345 1.000 1.000 476 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(5), ADRB2(1), CFTR(11), GNAS(6), PRKACG(2), PRKAR2B(1), SLC9A3R1(1) 1179243 27 22 26 19 18 2 1 3 3 0 0.776 1.000 1.000 477 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 20 ANPEP(3), CD2(3), CD33(4), CD5(3), IFNB1(2), IL10(1), IL12A(1), IL5(1), ITGAX(1), TLR2(3), TLR7(3), TLR9(5) 1541902 30 22 29 24 18 1 2 4 5 0 0.754 1.000 1.000 478 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(1), CALM1(1), GNAQ(1), HRAS(1), MAP2K1(4), MAP2K2(1), MAP2K3(2), MAP2K4(1), MAP3K1(1), MAPK1(3), MAPK3(1), PAK1(1), PRKCA(1), RAC1(3), RAF1(2), SOS1(1), SYT1(4) 2593084 29 22 28 24 20 1 1 2 5 0 0.970 1.000 1.000 479 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(4), EEF1B2(1), EEF1D(1), EEF2K(3), EIF1AX(1), EIF2AK1(1), EIF2AK2(1), EIF2AK3(3), EIF2B1(1), EIF2B2(1), EIF2B5(1), EIF4A1(1), EIF4A2(1), EIF4G1(3), EIF4G3(2), EIF5(1), EIF5B(1), GSPT2(1), KIAA0664(1), PABPC3(1) 3968528 30 22 30 17 9 3 2 7 9 0 0.866 1.000 1.000 480 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ABAT(4), ACADS(2), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH5A1(2), GAD1(3), GAD2(1), HADHA(1), HMGCL(1), OXCT1(1), PDHA1(1), PDHA2(2), PDHB(1) 2362677 29 21 28 17 19 2 3 4 1 0 0.676 1.000 1.000 481 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(3), EGF(4), EGFR(6), MET(6), PDGFRA(7), PRKCA(1) 1776448 27 21 27 13 18 1 3 3 2 0 0.473 1.000 1.000 482 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(5), CAMK2B(2), CAMK2D(1), CAMK2G(1), GNAS(6), HRAS(1), MAPK1(3), MAPK3(1), PIK3CA(1), PRKACG(2), PRKAR2B(1), PRKCA(1), RAC1(3), RPS6KA1(3), SOS1(1) 2635171 32 21 32 22 24 2 0 2 4 0 0.835 1.000 1.000 483 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 22 BCAR1(1), CXCL12(1), CXCR4(1), GNAQ(1), HRAS(1), MAP2K1(4), MAPK1(3), MAPK3(1), NFKB1(3), PIK3CA(1), PRKCA(1), PTK2(3), RAF1(2), RELA(2) 2278974 25 21 25 21 12 3 0 5 5 0 0.980 1.000 1.000 484 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(4), ALDH4A1(2), ALDH5A1(2), CAD(3), CPS1(4), EPRS(2), GAD1(3), GAD2(1), GCLC(2), GMPS(1), GOT2(3), GSS(1), NADSYN1(1), QARS(2) 3033256 31 21 31 15 16 4 3 5 3 0 0.499 1.000 1.000 485 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT2(1), EXTL1(1), EXTL3(1), GLCE(2), HS3ST1(2), HS3ST2(3), HS3ST5(1), HS6ST3(2), NDST2(1), NDST3(5), NDST4(8) 1851389 27 21 27 24 18 1 1 5 2 0 0.961 1.000 1.000 486 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 21 ADH1A(2), ADH1C(8), ADH4(2), ADH5(1), ADH7(5), ADHFE1(3), DHRS2(2), DHRS3(1), DHRSX(1), MYST3(4), MYST4(1) 2213963 30 21 28 13 19 2 1 5 3 0 0.485 1.000 1.000 487 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(1), CREBBP(6), EP300(4), FYN(2), IL2RG(1), IL7(2), IL7R(6), JAK1(1), JAK3(2), LCK(4), PIK3CA(1), STAT5B(1) 2540963 31 21 30 18 15 5 1 7 3 0 0.837 1.000 1.000 488 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT2(4), AKT3(2), IL2RG(1), IL4R(6), INPP5D(7), JAK1(1), JAK2(1), JAK3(2), NR0B2(1), PI3(1), PIK3CA(1), PPP1R13B(2), RPS6KB1(1), SOS1(1), SOS2(2), STAT6(1), TYK2(3) 3353409 37 21 37 17 22 3 3 5 4 0 0.477 1.000 1.000 489 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(2), GBA3(6), LPO(2), MPO(1), PRDX2(2), PRDX6(2), TPO(8) 882830 23 21 22 12 17 3 1 0 2 0 0.293 1.000 1.000 490 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(4), AXIN1(2), CREBBP(6), CSNK1A1(1), CTNNB1(1), FZD1(1), MAP3K7(1), MYC(2), NLK(3), PPARD(1), PPP2CA(1), TLE1(1), WIF1(2) 2661277 26 21 25 13 15 1 3 2 5 0 0.673 1.000 1.000 491 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(8), AGTR1(4), AGTR2(2), BDKRB2(3), KNG1(3), NOS3(2), REN(1) 897635 23 20 22 19 14 2 1 3 3 0 0.814 1.000 1.000 492 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(5), BAX(2), BCL2(1), CSF2RB(3), IGF1(2), IGF1R(1), IL3RA(1), KIT(2), KITLG(4), PIK3CA(1), PRKACG(2), PRKAR2B(1) 1993320 25 20 25 20 15 5 1 0 4 0 0.858 1.000 1.000 493 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(2), DRD1(3), DRD2(2), GRM1(3), PLCB1(13), PPP1R1B(1), PPP2CA(1), PRKACG(2), PRKAR2B(1) 1452189 28 20 27 20 20 0 2 4 2 0 0.758 1.000 1.000 494 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 31 AKR1B10(3), G6PC(2), G6PC2(1), GAA(4), GALK1(1), GALK2(1), GCK(3), GLB1(1), HK1(1), HK2(1), HK3(2), HSD3B7(2), LALBA(1), LCT(6), RDH13(1) 3203572 30 20 30 30 22 3 1 2 2 0 0.954 1.000 1.000 495 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(2), GBA(1), GBA3(6), LPO(2), MPO(1), PRDX6(2), TPO(8) 768114 22 20 21 12 15 3 1 0 3 0 0.308 1.000 1.000 496 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(1), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), BBOX1(1), DOT1L(1), EHMT1(1), EHMT2(1), GCDH(2), HADHA(1), PLOD1(1), PLOD2(1), SHMT2(1) 3347897 22 20 22 17 15 2 2 3 0 0 0.865 1.000 1.000 497 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 19 B2M(1), HLA-A(2), ITGB1(1), KLRC1(1), MAP2K1(4), MAPK3(1), PAK1(1), PIK3CA(1), RAC1(3), SYK(3), VAV1(3) 1649994 21 20 21 18 13 1 1 2 4 0 0.970 1.000 1.000 498 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 ATF1(1), CREB5(2), DUSP10(2), EEF2K(3), IL1R1(5), MAP2K3(2), MAP2K4(1), MAP3K4(3), MAP3K5(3), MAP3K7(1), MAPK1(3), MAPKAPK2(2), NFKB1(3), SRF(1) 3035313 32 20 31 15 22 1 1 3 5 0 0.364 1.000 1.000 499 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(1), CHAT(3), COMT(1), DBH(4), DDC(2), GAD1(3), GAD2(1), HDC(5), PAH(3), SLC18A3(1), TH(1), TPH1(2) 1291618 27 19 27 15 20 2 2 0 3 0 0.319 1.000 1.000 500 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(3), CYP11A1(4), CYP11B1(3), CYP11B2(6), CYP21A2(4), HSD11B1(3), HSD11B2(1), HSD3B2(3) 894911 30 19 28 17 20 2 3 3 2 0 0.279 1.000 1.000 501 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 EIF4A1(1), EIF4A2(1), EIF4G1(3), EIF4G2(1), EIF4G3(2), GHR(4), IRS1(3), MAPK1(3), MAPK3(1), PIK3CA(1), PRKCA(1), PTEN(4), RPS6KB1(1) 2582590 26 19 26 14 8 5 4 2 7 0 0.807 1.000 1.000 502 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 23 FBP2(1), G6PC(2), GAA(4), GALK1(1), GALK2(1), GANAB(1), GCK(3), GLB1(1), HK1(1), HK2(1), HK3(2), LALBA(1), LCT(6) 2648421 25 19 25 24 17 3 1 2 2 0 0.928 1.000 1.000 503 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSD(1), ARSE(1), GAL3ST1(1), GBA(1), GLB1(1), LCT(6), NEU2(2), NEU3(1), NEU4(4), PPAP2C(1), SMPD1(1), SPTLC2(2) 2179189 22 19 22 17 16 1 0 3 2 0 0.853 1.000 1.000 504 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(2), FBP2(1), G6PD(1), H6PD(3), PGD(2), PRPS1L1(4), RBKS(1), TALDO1(2), TKT(1), TKTL2(5) 2211954 22 19 22 21 13 2 1 3 3 0 0.923 1.000 1.000 505 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(3), CYP11A1(4), CYP11B1(3), CYP11B2(6), CYP21A2(4), HSD11B1(3), HSD11B2(1), HSD3B2(3) 894911 30 19 28 17 20 2 3 3 2 0 0.279 1.000 1.000 506 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), IARS2(5), ILVBL(2), LARS(2), LARS2(2), PDHA1(1), PDHA2(2), PDHB(1), VARS(7), VARS2(1) 1722323 24 19 22 11 10 5 1 4 4 0 0.560 1.000 1.000 507 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(3), ABCC2(2), ABCG2(1), CES1(5), CES2(1), CYP3A4(4), CYP3A5(3), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A7(4), UGT1A8(1) 2089952 29 19 28 20 17 4 2 2 4 0 0.687 1.000 1.000 508 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 FOS(1), HRAS(1), JAK1(1), MAP2K1(4), MAP2K4(1), MAP3K1(1), MAPK3(1), PDGFRA(7), PIK3CA(1), PRKCA(1), RAF1(2), RASA1(3), SOS1(1), SRF(1), STAT1(2) 3175759 28 19 28 21 12 3 0 6 7 0 0.991 1.000 1.000 509 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(5), ADRB2(1), GNAS(6), PLCE1(11), PRKACG(2), PRKAR2B(1) 1328016 26 19 26 14 16 3 2 3 2 0 0.522 1.000 1.000 510 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 25 ALAD(1), BLVRA(1), CP(2), EPRS(2), FECH(3), HMOX2(1), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A7(4), UGT1A8(1), UGT2B15(5) 2423947 25 19 25 21 15 3 3 1 3 0 0.926 1.000 1.000 511 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), EGR2(1), GNAQ(1), MAP3K1(1), MYC(2), NFATC1(2), NFATC2(1), NFKB1(3), PRKACG(2), PRKAR2B(1), RELA(2), SYT1(4), VIP(1), VIPR2(2) 2539456 24 19 23 19 17 2 2 2 1 0 0.913 1.000 1.000 512 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(5), GNAS(6), PPP2CA(1), PRKAA2(5), PRKAB2(1), PRKACG(2), PRKAG1(1), PRKAG2(1), PRKAR2B(1) 1389164 23 18 23 16 17 2 2 0 2 0 0.784 1.000 1.000 513 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGF(4), EGFR(6), FOS(1), HRAS(1), JAK1(1), MAP2K1(4), MAP2K4(1), MAP3K1(1), MAPK3(1), PIK3CA(1), PRKCA(1), RAF1(2), RASA1(3), SOS1(1), SRF(1), STAT1(2) 3410636 31 18 31 18 15 3 2 5 6 0 0.940 1.000 1.000 514 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOB(2), FBP2(1), FPGT(1), GCK(3), HK1(1), HK2(1), HK3(2), MPI(1), PFKFB1(1), PFKFB4(1), PMM1(2), PMM2(1), SORD(2) 2172235 19 18 19 19 8 6 3 0 2 0 0.907 1.000 1.000 515 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 BCL2(1), BCR(2), FOS(1), HRAS(1), JAK2(1), MAP2K1(4), MAP2K4(1), MAP3K1(1), MAPK3(1), MYC(2), PIK3CA(1), RAF1(2), SOS1(1), STAT1(2), STAT5B(1) 2549541 22 18 22 15 10 2 0 4 6 0 0.962 1.000 1.000 516 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 CABIN1(2), CALM1(1), CAMK1G(3), HDAC5(2), IGF1(2), IGF1R(1), INSR(2), MAPK7(2), MEF2A(2), MEF2B(1), MEF2C(1), MEF2D(2), MYOD1(1), NFATC1(2), NFATC2(1), PIK3CA(1), SYT1(4) 3175365 30 18 29 19 18 5 3 2 2 0 0.749 1.000 1.000 517 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIA(1), CHIT1(4), CTBS(3), CYB5R1(1), GFPT2(1), GNE(2), HEXA(1), HEXB(1), HK1(1), HK2(1), HK3(2), LHPP(1), MTMR1(2), UAP1(1) 2616103 22 18 22 15 15 2 0 3 2 0 0.781 1.000 1.000 518 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 GALNS(1), GLB1(1), HEXA(1), HEXB(1), HGSNAT(1), HPSE(3), HPSE2(1), HYAL1(2), IDS(1), IDUA(1), LCT(6), SPAM1(5) 1848200 24 18 24 20 18 1 0 3 2 0 0.921 1.000 1.000 519 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT2(3), AGPAT4(3), AGPAT6(1), AGPS(1), CHPT1(1), ENPP6(1), PAFAH1B1(1), PAFAH2(1), PLA2G1B(1), PLA2G2D(1), PLA2G2F(2), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), PLD1(2), PLD2(3), PPAP2C(1) 2126785 32 18 32 19 19 1 2 7 3 0 0.744 1.000 1.000 520 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(2), FBP2(1), GOT2(3), MDH2(1), ME1(3), ME3(1), PGK2(5), PKLR(2), PKM2(1), TKT(1), TKTL2(5) 1850268 25 18 25 20 16 3 2 2 2 0 0.807 1.000 1.000 521 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(17), CYP2C9(9) 183881 26 18 25 16 19 1 2 1 3 0 0.575 1.000 1.000 522 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 FOS(1), HRAS(1), IL2(1), IL2RA(1), IL2RG(1), JAK1(1), JAK3(2), LCK(4), MAP2K1(4), MAPK3(1), RAF1(2), SOS1(1), STAT5B(1), SYK(3) 2097971 24 18 24 13 13 0 1 6 4 0 0.803 1.000 1.000 523 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), ALG5(1), B4GALT5(2), DDOST(1), FUT8(1), MAN1A1(4), MAN1B1(1), MGAT2(2), MGAT3(3), MGAT4A(1), MGAT5(2), RPN2(1) 1825212 21 18 21 16 11 2 1 6 1 0 0.891 1.000 1.000 524 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(3), CREBBP(6), EP300(4), NCOA3(2), PRKACG(2), PRKAR2B(1), RXRA(1) 1889869 19 17 19 10 12 1 1 4 1 0 0.750 1.000 1.000 525 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(3), ACTN3(2), BCAR1(1), CTNNA2(4), CTNNB1(1), PTK2(3), VCL(3) 1721109 18 17 18 16 7 1 2 4 4 0 0.921 1.000 1.000 526 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(1), CALM1(1), GNAS(6), NFKB1(3), NOS3(2), NPPA(1), NR3C1(2), PIK3CA(1), RELA(2), SYT1(4) 1614263 23 17 22 15 15 3 0 4 1 0 0.875 1.000 1.000 527 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA1(1), GLB1(1), HEXA(1), HEXB(1), LCT(6), MAN2B1(2), MAN2B2(3), NEU2(2), NEU3(1), NEU4(4) 1853191 22 17 22 11 17 2 0 2 1 0 0.405 1.000 1.000 528 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLA2(3), POLD1(2), POLD3(1), POLE(1), POLE2(1), POLG(1), POLG2(1), POLK(2), POLL(1), POLQ(5), PRIM2(3), REV3L(3) 3689119 25 17 25 13 10 1 2 10 2 0 0.802 1.000 1.000 529 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG5(1), ATG7(1), BECN1(2), IFNA16(1), IFNA2(1), IFNA21(1), IFNA4(1), IFNA8(1), PIK3C3(2), PIK3R4(3), PRKAA2(5), ULK1(2), ULK2(1) 1896740 23 17 23 13 19 1 1 1 1 0 0.553 1.000 1.000 530 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(2), CASP3(1), CASP7(3), CASP8(2), GAPDH(1), INSR(2), ITCH(1), MAGI1(3), MAGI2(5), RERE(6), WWP1(1), WWP2(1) 2195354 28 17 27 15 15 2 1 5 4 1 0.764 1.000 1.000 531 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 FOS(1), HRAS(1), IL6(1), IL6R(2), IL6ST(2), JAK1(1), JAK2(1), JAK3(2), MAP2K1(4), MAPK3(1), PTPN11(1), RAF1(2), SOS1(1), SRF(1) 2164669 21 17 21 16 10 0 0 5 6 0 0.990 1.000 1.000 532 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 GLI2(9), GLI3(3), PRKACG(2), PRKAR2B(1), SHH(1), SMO(1) 1510601 17 17 17 14 12 1 2 1 1 0 0.867 1.000 1.000 533 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K4(1), MAP2K7(1), MAPK1(3), MAPK10(2), MAPK3(1), MAPK8IP2(2), MAPK8IP3(3), NFKB1(3), NFKB2(2), NFKBIL2(2), PIK3CA(1), PIK3CD(1), SYT1(4), TRAF5(2) 3050574 28 17 27 18 21 1 1 3 2 0 0.644 1.000 1.000 534 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(1), ARFGAP3(2), ARFGEF2(9), CLTB(1), COPA(1), GBF1(1), GPLD1(5) 1494678 20 16 20 11 12 1 1 4 2 0 0.695 1.000 1.000 535 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 AGTR2(2), EDNRA(2), EDNRB(1), EGF(4), EGFR(6), FOS(1), HRAS(1), MYC(2), NFKB1(3), PRKCA(1), RELA(2) 1872104 25 16 25 12 15 2 2 3 3 0 0.546 1.000 1.000 536 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(2), EPX(2), LPO(2), MPO(1), PRDX6(2), SHMT2(1), TPO(8) 1068663 19 16 19 11 14 3 1 0 1 0 0.377 1.000 1.000 537 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(6), ENPP3(4), NADK(1), NADSYN1(1), NNMT(1), NNT(3), NT5C1A(1), NT5C1B(4), NT5C2(1), QPRT(2) 1969464 24 16 24 17 16 2 1 3 2 0 0.829 1.000 1.000 538 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 FOS(1), HRAS(1), IGF1(2), IGF1R(1), IRS1(3), MAP2K1(4), MAPK3(1), PIK3CA(1), PTPN11(1), RAF1(2), RASA1(3), SOS1(1), SRF(1) 2254539 22 16 22 12 7 6 1 3 5 0 0.879 1.000 1.000 539 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 FOS(1), HRAS(1), INSR(2), IRS1(3), MAP2K1(4), MAPK3(1), PIK3CA(1), PTPN11(1), RAF1(2), RASA1(3), SLC2A4(1), SOS1(1), SRF(1) 2331283 22 16 22 17 7 4 1 5 5 0 0.991 1.000 1.000 540 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(7), CPT1A(2), LEPR(7), PRKAA2(5), PRKAB2(1), PRKAG1(1), PRKAG2(1) 1332085 24 16 23 16 16 1 2 2 3 0 0.868 1.000 1.000 541 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CAMK1G(3), CAMK2B(2), CAMK2D(1), CAMK2G(1), CAMK4(1), HDAC5(2), MEF2A(2), MEF2B(1), MEF2C(1), MEF2D(2), PPARA(2), SLC2A4(1), SYT1(4) 1828919 24 16 23 14 19 0 0 3 2 0 0.608 1.000 1.000 542 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(4), APOA4(1), APOC1(1), APOE(1), CYP7A1(1), DGAT1(1), LDLR(2), LIPC(1), LPL(1), LRP1(10), SCARB1(2) 2519691 25 16 25 17 13 2 2 5 3 0 0.774 1.000 1.000 543 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 FOS(1), HRAS(1), JAK2(1), MAP2K1(4), MAPK3(1), MPL(2), PIK3CA(1), PRKCA(1), RAF1(2), RASA1(3), SOS1(1), STAT1(2), STAT5B(1), THPO(1) 2722971 22 16 22 17 9 3 0 6 4 0 0.990 1.000 1.000 544 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(2), CARS(1), DARS(4), EPRS(2), FARS2(2), HARS(3), LARS(2), LARS2(2), QARS(2), SARS(1), WARS(1), WARS2(2) 2936980 24 15 23 13 14 2 1 3 4 0 0.685 1.000 1.000 545 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(5), FHL5(3), FSHB(2), FSHR(3), GNAS(6) 863028 19 15 19 15 15 1 0 0 3 0 0.865 1.000 1.000 546 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(1), ASRGL1(1), CA1(2), CA13(1), CA2(2), CA3(1), CA4(1), CA6(1), CA8(2), CA9(1), CPS1(4), HAL(3) 1920487 20 15 20 10 14 2 0 1 3 0 0.454 1.000 1.000 547 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 20 IL1A(1), IL1R1(5), IRAK1(1), MAP3K1(1), MAP3K14(2), MAP3K7(1), MYD88(1), NFKB1(3), RELA(2), RIPK1(1), TNFAIP3(1), TNFRSF1A(1), TNFRSF1B(2) 2035479 22 15 22 11 13 2 2 3 2 0 0.595 1.000 1.000 548 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD2(3), CD3D(1), CD3G(1), CXCR3(1), IL12A(1), IL12RB1(3), IL12RB2(1), JAK2(1), STAT4(1), TYK2(3) 1320077 16 15 16 10 8 4 0 2 2 0 0.720 1.000 1.000 549 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(2), FBP2(1), G6PD(1), H6PD(3), PGD(2), PRPS1L1(4), RBKS(1), TALDO1(2), TKT(1) 1860980 17 15 17 15 9 1 1 3 3 0 0.883 1.000 1.000 550 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 PIK3CA(1), PLCB1(13), PRKCA(1), VAV1(3) 1172746 18 15 17 13 15 1 0 1 1 0 0.830 1.000 1.000 551 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CRADD(1), MAP2K3(2), MAP2K4(1), MAP3K1(1), MAP3K14(2), MAP4K2(1), NFKB1(3), RELA(2), RIPK1(1), TNFRSF1A(1) 2168429 16 15 16 11 8 3 0 3 2 0 0.846 1.000 1.000 552 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD3G(1), FYN(2), HLA-DRA(3), LCK(4), PTPRC(3), ZAP70(3) 806388 17 15 17 11 10 2 0 3 2 0 0.720 1.000 1.000 553 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(3), CD3D(1), CD3G(1), CD8A(1), ICAM1(1), ITGAL(3), ITGB2(4), PTPRC(3) 966925 17 15 17 14 9 2 0 2 4 0 0.871 1.000 1.000 554 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(3), CD3D(1), CD3G(1), ICAM1(1), ITGAL(3), ITGB2(4), PTPRC(3) 1013444 16 15 16 14 8 2 0 2 4 0 0.900 1.000 1.000 555 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD3D(1), CD3G(1), CD80(1), CTLA4(2), HLA-DRA(3), IL2(1), ITK(3), LCK(4), PIK3CA(1), PTPN11(1) 1103163 18 14 18 12 14 1 0 1 2 0 0.829 1.000 1.000 556 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(1), ALOX15(1), ALOX15B(1), ALOX5(2), GGT1(1), LTA4H(1), PLA2G6(3), PTGIS(5), PTGS1(3), PTGS2(3), TBXAS1(2) 1358531 23 14 23 15 12 4 0 6 1 0 0.597 1.000 1.000 557 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(1), CYP11A1(4), CYP11B2(6), HSD11B1(3), HSD11B2(1), HSD3B2(3) 628487 18 14 17 14 14 1 0 1 2 0 0.476 1.000 1.000 558 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), GPR109B(1), GPR161(1), GPR171(1), GPR39(5), GPR45(2), GPR65(1), GPR68(2), GPR75(1) 889040 16 14 16 13 13 1 1 1 0 0 0.592 1.000 1.000 559 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(3), FOS(1), HRAS(1), IL3RA(1), JAK2(1), MAP2K1(4), MAPK3(1), RAF1(2), SOS1(1), STAT5B(1) 1601865 16 14 16 15 8 0 0 3 5 0 0.991 1.000 1.000 560 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(8), MAP2(1), PPP2CA(1), PRKACG(2), PRKAG1(1), PRKAR2B(1) 1650272 14 13 14 13 9 1 2 0 2 0 0.975 1.000 1.000 561 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CAMK1G(3), CAMK2B(2), CAMK2D(1), CAMK2G(1), CAMK4(1), CAMKK1(1), CAMKK2(3), SYT1(4) 1059881 17 13 16 10 12 1 0 3 1 0 0.569 1.000 1.000 562 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 HRAS(1), MAPK1(3), MAPK3(1), MAPK7(2), MEF2A(2), MEF2B(1), MEF2C(1), MEF2D(2), NTRK1(2), PIK3CA(1), RPS6KA1(3) 1724673 19 13 19 13 12 3 0 1 3 0 0.833 1.000 1.000 563 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(1), LCT(6), MPI(1), PYGL(3), PYGM(3), TREH(1) 1203045 15 13 15 15 11 2 0 2 0 0 0.882 1.000 1.000 564 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 GABRA1(2), GABRA2(1), GABRA3(8), GABRA4(1), GABRA6(3), GPHN(1), UBQLN1(1) 1068362 17 13 17 19 12 2 1 0 2 0 0.981 1.000 1.000 565 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 GLB1(1), HEXA(1), HEXB(1), LCT(6), SLC33A1(1), ST3GAL1(2), ST3GAL5(2), ST6GALNAC3(2), ST6GALNAC4(1), ST8SIA5(3) 1503273 20 13 20 11 15 1 0 4 0 0 0.526 1.000 1.000 566 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(6), ENPP3(4), NADSYN1(1), NNMT(1), NNT(3), QPRT(2) 1332269 17 13 17 13 10 2 1 2 2 0 0.862 1.000 1.000 567 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 17 UCHL3(1), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A7(4), UGT1A8(1), UGT2B15(5) 1519681 16 13 16 21 10 3 2 0 1 0 0.993 1.000 1.000 568 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 IKBKAP(2), MAP3K1(1), MAP3K14(2), NFKB1(3), RELA(2), RIPK1(1), TNFAIP3(1), TNFRSF1B(2), TRAF1(1) 2034395 15 13 15 14 7 3 0 4 1 0 0.978 1.000 1.000 569 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(2), FBP2(1), GOT2(3), MDH2(1), ME1(3), ME3(1), PKLR(2), PKM2(1), TKT(1) 1653919 15 12 15 10 8 2 2 1 2 0 0.736 1.000 1.000 570 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 EPO(1), EPOR(1), FOS(1), HRAS(1), JAK2(1), MAP2K1(4), MAPK3(1), RAF1(2), SOS1(1), STAT5B(1) 1942027 14 12 14 13 6 0 1 3 4 0 0.993 1.000 1.000 571 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(2), CRY1(1), NPAS2(1), PER1(3), PER2(1), PER3(4) 1549784 12 12 12 13 10 0 0 1 1 0 0.966 1.000 1.000 572 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL22(1), IL22RA1(2), JAK1(1), JAK2(1), JAK3(2), SOCS3(1), STAT1(2), STAT5B(1), TYK2(3) 1660280 14 12 14 13 8 0 1 3 2 0 0.958 1.000 1.000 573 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(3), BIN1(1), CALM1(1), EPN1(3), PICALM(1), SYNJ1(3), SYNJ2(2), SYT1(4) 1958050 18 12 17 16 14 1 0 3 0 0 0.953 1.000 1.000 574 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 BTK(4), LYN(1), PRKCZ(2), RAC1(3), RPS6KB1(1), VAV2(2) 2263093 13 12 13 11 7 0 1 2 3 0 0.855 1.000 1.000 575 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 CHRNB1(1), MUSK(6), PIK3CA(1), PTK2(3), TERT(1) 1478848 12 11 12 18 7 2 0 2 1 0 0.996 1.000 1.000 576 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 CASP9(1), GHR(4), NFKB1(3), PIK3CA(1), PPP2CA(1), RELA(2) 1274349 12 11 12 11 6 3 1 2 0 0 0.963 1.000 1.000 577 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(1), MAPK3(1), OPRK1(3), POLR2A(4), PRKACG(2), PRKAR2B(1) 1168011 12 11 12 15 10 0 1 0 1 0 0.978 1.000 1.000 578 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(2), GABRA2(1), GABRA3(8), GABRA4(1), GABRA6(3) 702169 15 11 15 16 11 2 0 0 2 0 0.961 1.000 1.000 579 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 FOS(1), HRAS(1), MAP2K1(4), MAPK3(1), NGFR(3), PIK3CA(1), RAF1(2), SOS1(1) 1734702 14 11 14 11 7 2 0 2 3 0 0.973 1.000 1.000 580 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(1), IL6R(2), JAK1(1), JAK2(1), JAK3(2), PIAS3(1), PTPRU(2), REG1A(1) 1382782 11 11 11 10 6 1 0 2 2 0 0.936 1.000 1.000 581 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(6), HSD17B2(2), HSD17B3(2), HSD17B4(1), HSD17B7(1), HSD3B2(3) 730707 15 11 15 11 9 2 1 0 3 0 0.718 1.000 1.000 582 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(6), PRKACG(2), PRKAR2B(1), PRKCA(1) 862126 12 10 12 7 10 2 0 0 0 0 0.622 1.000 1.000 583 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 IKBKAP(2), MAP3K1(1), MAP3K14(2), NFKB1(3), RELA(2), TNFAIP3(1) 1645850 11 10 11 12 3 3 0 4 1 0 0.993 1.000 1.000 584 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(3), IL5(1), MAF(1), MAP2K3(2), NFATC1(2), NFATC2(1), PRKACG(2), PRKAR2B(1) 1100580 13 10 13 11 9 2 2 0 0 0 0.802 1.000 1.000 585 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(4), CDO1(1), GAD1(3), GAD2(1), GGT1(1) 515640 10 10 10 8 6 1 1 2 0 0 0.848 1.000 1.000 586 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3D(1), CD3G(1), IL2(1), IL2RA(1), TGFB1(1), TGFB3(1), TGFBR2(3), TGFBR3(3), TOB1(1) 961270 13 10 13 10 11 1 0 0 1 0 0.825 1.000 1.000 587 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), CHAT(3), PDHA1(1), PDHA2(2), PEMT(1), SLC18A3(1) 625039 9 9 8 9 7 2 0 0 0 0 0.859 1.000 1.000 588 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACOT11(1), DHRS2(2), DHRS3(1), DHRSX(1), GCDH(2), HADHA(1), MYST3(4), MYST4(1) 2382863 13 9 13 13 5 2 0 3 3 0 0.988 1.000 1.000 589 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(1), ATIC(1), GART(4), MTHFD1(2), MTR(1), SHMT2(1) 1730604 10 9 10 10 8 2 0 0 0 0 0.921 1.000 1.000 590 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP6(1), ENPP3(4), FLAD1(2), LHPP(1), MTMR1(2) 1371041 11 9 11 11 6 1 1 2 1 0 0.969 1.000 1.000 591 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 SEC22B(1), SNAP25(3), STX19(1), STX2(2), TSNARE1(2), VAMP4(1), VAMP7(1), VAMP8(1) 1512695 12 9 12 11 6 1 0 4 1 0 0.951 1.000 1.000 592 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 CAT(2), GHR(4), HRAS(1), IGF1(2), IGF1R(1), PIK3CA(1) 1209750 11 9 11 10 6 4 0 0 1 0 0.949 1.000 1.000 593 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(1), ATIC(1), GART(4), MTHFD1(2), MTR(1), SHMT2(1) 1632467 10 9 10 8 8 2 0 0 0 0 0.818 1.000 1.000 594 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CXCL12(1), CXCR4(1), FOS(1), GNAQ(1), PRKCA(1), SYT1(4) 1260945 10 8 9 16 8 0 0 0 2 0 0.994 1.000 1.000 595 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 GALNS(1), GLB1(1), HEXA(1), HEXB(1), IDS(1), IDUA(1), LCT(6) 1302089 12 8 12 13 11 0 0 1 0 0 0.948 1.000 1.000 596 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 DNAJC3(1), MAP3K14(2), NFKB1(3), RELA(2) 810639 8 8 8 5 3 2 0 3 0 0 0.836 1.000 1.000 597 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(1), CHST12(1), PAPSS2(1), SULT1A1(1), SULT1A2(1), SULT1E1(3), SULT2A1(2), SULT2B1(1), SUOX(1) 832164 12 7 12 8 10 1 0 1 0 0 0.630 1.000 1.000 598 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(1), ESR1(1), GREB1(2), MTA3(1), PDZK1(1), TUBA8(2) 977301 8 7 8 7 8 0 0 0 0 0 0.695 1.000 1.000 599 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(2), CRY1(1), PER1(3) 766907 6 6 6 6 5 0 0 1 0 0 0.933 1.000 1.000 600 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(6), PNPO(1) 445320 7 6 7 6 6 1 0 0 0 0 0.822 1.000 1.000 601 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(2), NR0B2(1), NR1H4(2), RXRA(1) 495536 6 5 6 7 4 1 0 1 0 0 0.898 1.000 1.000 602 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(2), TPK1(2) 585665 5 5 5 4 5 0 0 0 0 0 0.886 1.000 1.000 603 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT2(2), FUT3(1) 455370 4 4 4 4 2 1 0 1 0 0 0.815 1.000 1.000 604 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CSF1(1), IL6(1), LDLR(2), LPL(1) 488132 5 4 5 4 2 1 0 2 0 0 0.842 1.000 1.000 605 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 POLD1(2), POLG(1), RRM1(1) 1134528 4 4 4 8 4 0 0 0 0 0 0.990 1.000 1.000 606 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(2), OAT(1) 498813 3 3 3 3 0 2 0 1 0 0 0.951 1.000 1.000 607 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 GCDH(2), HADHA(1) 713013 3 3 3 3 1 1 0 1 0 0 0.917 1.000 1.000 608 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), HGD(2) 205513 3 3 3 6 3 0 0 0 0 0 0.978 1.000 1.000 609 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), HADHA(1) 442566 2 2 2 3 1 0 0 1 0 0 0.956 1.000 1.000 610 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 7 COQ2(1), COQ5(1) 340621 2 2 2 2 2 0 0 0 0 0 0.878 1.000 1.000 611 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(1) 630206 2 2 2 3 2 0 0 0 0 0 0.963 1.000 1.000 612 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 HMGCL(1), OXCT1(1) 307069 2 2 2 3 0 1 0 1 0 0 0.977 1.000 1.000 613 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD3D(1), CD3G(1) 291749 2 2 2 5 2 0 0 0 0 0 0.971 1.000 1.000 614 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1), CD3G(1) 102220 2 2 2 3 2 0 0 0 0 0 0.943 1.000 1.000 615 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 415501 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 616 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 141505 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000