Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.059 0.19 -9999.0 0.0 -0.497 7.0 7.0 IHH -0.004 0.044 -9999.0 0.0 -0.175 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.005 0.068 -9999.0 0.0 -0.202 6.0 6.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.005 0.068 0.201 6.0 -9999.0 0.0 6.0 SMO/beta Arrestin2 -0.054 0.144 -9999.0 0.0 -0.475 3.0 3.0 SMO -0.063 0.15 -9999.0 0.0 -0.504 3.0 3.0 AKT1 -0.013 0.073 -9999.0 0.0 -0.253 1.0 1.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.052 0.142 -9999.0 0.0 -0.356 11.0 11.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.062 0.148 -9999.0 0.0 -0.496 3.0 3.0 STIL -0.021 0.099 -9999.0 0.0 -0.499 1.0 1.0 DHH N/PTCH2 -0.044 0.121 -9999.0 0.0 -0.261 14.0 14.0 DHH N/PTCH1 -0.045 0.139 -9999.0 0.0 -0.315 9.0 9.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.039 0.127 -9999.0 0.0 -0.347 9.0 9.0 PTHLH -0.069 0.234 -9999.0 0.0 -0.65 7.0 7.0 determination of left/right symmetry -0.062 0.148 -9999.0 0.0 -0.496 3.0 3.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.068 0.232 -9999.0 0.0 -0.643 7.0 7.0 IHH N/Hhip -0.013 0.075 -9999.0 0.0 -0.253 5.0 5.0 DHH N/Hhip -0.038 0.113 -9999.0 0.0 -0.26 12.0 12.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.062 0.148 -9999.0 0.0 -0.496 3.0 3.0 pancreas development -0.018 0.09 -9999.0 0.0 -0.322 5.0 5.0 HHAT 0.007 0.051 -9999.0 0.0 -0.395 1.0 1.0 PI3K 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.0 0.072 -9999.0 0.0 -0.395 2.0 2.0 somite specification -0.062 0.148 -9999.0 0.0 -0.496 3.0 3.0 SHH Np/Cholesterol/PTCH1 -0.027 0.104 -9999.0 0.0 -0.528 1.0 1.0 SHH Np/Cholesterol/PTCH2 -0.019 0.078 -9999.0 0.0 -0.181 11.0 11.0 SHH Np/Cholesterol/Megalin -0.105 0.108 -9999.0 0.0 -0.187 37.0 37.0 SHH -0.008 0.065 -9999.0 0.0 -0.226 5.0 5.0 catabolic process -0.028 0.128 -9999.0 0.0 -0.348 5.0 5.0 SMO/Vitamin D3 -0.043 0.117 -9999.0 0.0 -0.483 2.0 2.0 SHH Np/Cholesterol/Hhip -0.015 0.07 -9999.0 0.0 -0.177 9.0 9.0 LRP2 -0.193 0.183 -9999.0 0.0 -0.352 35.0 35.0 receptor-mediated endocytosis -0.104 0.13 -9999.0 0.0 -0.403 5.0 5.0 SHH Np/Cholesterol/BOC -0.032 0.088 -9999.0 0.0 -0.184 15.0 15.0 SHH Np/Cholesterol/CDO -0.005 0.07 -9999.0 0.0 -0.202 6.0 6.0 mesenchymal cell differentiation 0.015 0.069 0.176 9.0 -9999.0 0.0 9.0 mol:Vitamin D3 -0.025 0.106 -9999.0 0.0 -0.53 1.0 1.0 IHH N/PTCH2 -0.02 0.092 -9999.0 0.0 -0.269 7.0 7.0 CDON 0.0 0.072 -9999.0 0.0 -0.395 2.0 2.0 IHH N/PTCH1 -0.026 0.13 -9999.0 0.0 -0.35 5.0 5.0 Megalin/LRPAP1 -0.125 0.128 -9999.0 0.0 -0.235 35.0 35.0 PTCH2 -0.027 0.113 -9999.0 0.0 -0.343 7.0 7.0 SHH Np/Cholesterol -0.005 0.049 -9999.0 0.0 -0.167 5.0 5.0 PTCH1 -0.028 0.129 -9999.0 0.0 -0.349 5.0 5.0 HHIP -0.018 0.09 -9999.0 0.0 -0.323 5.0 5.0