Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.053 0.091 -9999.0 0.0 -0.189 17.0 17.0 epithelial cell differentiation -0.065 0.095 -9999.0 0.0 -0.177 17.0 17.0 CYFIP2 -0.011 0.092 -9999.0 0.0 -0.359 4.0 4.0 ENAH -0.026 0.075 -9999.0 0.0 -0.193 3.0 3.0 EGFR -0.043 0.129 -9999.0 0.0 -0.337 10.0 10.0 EPHA2 -0.005 0.083 -9999.0 0.0 -0.371 3.0 3.0 MYO6 -0.067 0.101 -9999.0 0.0 -0.35 2.0 2.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.013 0.055 -9999.0 0.0 -0.194 4.0 4.0 AQP5 -0.049 0.081 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.057 0.088 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.071 0.102 -9999.0 0.0 -0.319 3.0 3.0 EGF -0.088 0.172 -9999.0 0.0 -0.377 16.0 16.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.07 0.134 -9999.0 0.0 -0.486 4.0 4.0 cortical microtubule organization -0.065 0.095 -9999.0 0.0 -0.177 17.0 17.0 GO:0000145 -0.056 0.083 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.064 0.097 -9999.0 0.0 -0.178 17.0 17.0 MLLT4 0.0 0.072 -9999.0 0.0 -0.395 2.0 2.0 ARF6/GDP -0.063 0.071 -9999.0 0.0 -0.257 3.0 3.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.024 0.045 -9999.0 0.0 -0.191 2.0 2.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.047 0.083 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.058 0.089 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.028 0.042 -9999.0 0.0 -0.171 2.0 2.0 CDH1 -0.175 0.19 -9999.0 0.0 -0.363 31.0 31.0 EGFR/EGFR/EGF/EGF -0.132 0.132 -9999.0 0.0 -0.339 14.0 14.0 RhoA/GDP -0.058 0.088 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.06 0.098 -9999.0 0.0 -0.333 2.0 2.0 IGF-1R heterotetramer 0.007 0.051 -9999.0 0.0 -0.395 1.0 1.0 GIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.007 0.051 -9999.0 0.0 -0.395 1.0 1.0 IGF1 -0.019 0.108 -9999.0 0.0 -0.381 5.0 5.0 DIAPH1 -0.011 0.101 -9999.0 0.0 -0.56 2.0 2.0 Wnt receptor signaling pathway 0.065 0.095 0.177 17.0 -9999.0 0.0 17.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.063 0.071 -9999.0 0.0 -0.257 3.0 3.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.062 0.1 -9999.0 0.0 -0.34 2.0 2.0 EFNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.054 0.085 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.076 0.084 -9999.0 0.0 -0.296 3.0 3.0 SEC6/SEC8 -0.064 0.062 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.071 0.103 -9999.0 0.0 -0.324 3.0 3.0 HGF/MET -0.098 0.105 -9999.0 0.0 -0.31 8.0 8.0 HGF -0.019 0.108 -9999.0 0.0 -0.381 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.053 0.091 -9999.0 0.0 -0.19 17.0 17.0 actin cable formation -0.013 0.073 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 -0.105 0.121 -9999.0 0.0 -0.325 9.0 9.0 KIFC3 -0.058 0.089 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.061 0.089 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.065 0.095 -9999.0 0.0 -0.177 17.0 17.0 EXOC4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.058 0.089 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.058 0.089 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.032 0.083 -9999.0 0.0 -0.226 3.0 3.0 adherens junction assembly -0.083 0.115 -9999.0 0.0 -0.323 6.0 6.0 IGF-1R heterotetramer/IGF1 -0.084 0.096 -9999.0 0.0 -0.319 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.01 0.051 -9999.0 0.0 -0.269 2.0 2.0 MET -0.025 0.118 -9999.0 0.0 -0.383 6.0 6.0 PLEKHA7 -0.069 0.098 -9999.0 0.0 -0.31 2.0 2.0 mol:GTP 0.023 0.045 -9999.0 0.0 -0.19 2.0 2.0 establishment of epithelial cell apical/basal polarity -0.038 0.08 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.053 0.091 -9999.0 0.0 -0.189 17.0 17.0 regulation of cell-cell adhesion -0.06 0.098 -9999.0 0.0 -0.333 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.053 0.091 -9999.0 0.0 -0.19 17.0 17.0