Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.02 0.09 -9999.0 0.0 -0.169 16.0 16.0 epithelial cell differentiation 0.022 0.101 -9999.0 0.0 -0.142 15.0 15.0 CYFIP2 0.021 0.063 0.184 2.0 -0.283 2.0 4.0 ENAH -0.042 0.05 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.042 0.067 0.184 8.0 -0.283 1.0 9.0 EPHA2 0.021 0.059 0.184 1.0 -0.283 2.0 3.0 MYO6 -0.039 0.068 -9999.0 0.0 -0.256 2.0 2.0 CTNNB1 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.049 0.045 -9999.0 0.0 -0.151 2.0 2.0 AQP5 -0.016 0.059 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.038 0.059 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.034 0.065 -9999.0 0.0 -0.253 1.0 1.0 EGF -0.017 0.129 0.184 4.0 -0.283 11.0 15.0 NCKAP1 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.05 0.115 -9999.0 0.0 -0.343 6.0 6.0 cortical microtubule organization 0.022 0.101 -9999.0 0.0 -0.142 15.0 15.0 GO:0000145 -0.042 0.052 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.027 0.105 -9999.0 0.0 -0.143 15.0 15.0 MLLT4 0.02 0.04 -9999.0 0.0 -0.283 1.0 1.0 ARF6/GDP -0.049 0.051 -9999.0 0.0 -0.138 11.0 11.0 ARF6 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.053 0.05 -9999.0 0.0 -0.153 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.03 0.053 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.037 0.06 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.056 0.052 -9999.0 0.0 -0.146 2.0 2.0 CDH1 -0.015 0.163 0.184 13.0 -0.283 15.0 28.0 EGFR/EGFR/EGF/EGF -0.014 0.121 0.169 3.0 -0.168 21.0 24.0 RhoA/GDP 0.021 0.097 -9999.0 0.0 -0.138 15.0 15.0 actin cytoskeleton organization -0.049 0.065 -9999.0 0.0 -0.254 2.0 2.0 IGF-1R heterotetramer 0.023 0.039 -9999.0 0.0 -0.282 1.0 1.0 GIT1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.023 0.039 -9999.0 0.0 -0.283 1.0 1.0 IGF1 0.021 0.059 0.184 1.0 -0.283 2.0 3.0 DIAPH1 -0.012 0.201 -9999.0 0.0 -0.55 7.0 7.0 Wnt receptor signaling pathway -0.022 0.101 0.142 15.0 -9999.0 0.0 15.0 RHOA 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.049 0.051 -9999.0 0.0 -0.138 12.0 12.0 CTNNA1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.05 0.066 -9999.0 0.0 -0.259 2.0 2.0 EFNA1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.048 0.054 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 0.003 0.085 -9999.0 0.0 -0.136 15.0 15.0 SEC6/SEC8 -0.042 0.059 -9999.0 0.0 -0.139 14.0 14.0 MGAT3 -0.034 0.066 -9999.0 0.0 -0.256 1.0 1.0 HGF/MET -0.01 0.111 0.169 1.0 -0.159 20.0 21.0 HGF 0.01 0.08 0.184 1.0 -0.283 4.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.02 0.09 -9999.0 0.0 -0.17 16.0 16.0 actin cable formation -0.009 0.089 0.189 5.0 -9999.0 0.0 5.0 KIAA1543 -0.041 0.053 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 -0.039 0.059 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.039 0.059 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.04 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.022 0.101 -9999.0 0.0 -0.142 15.0 15.0 EXOC4 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.037 0.06 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.038 0.06 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.026 0.079 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.042 0.07 -9999.0 0.0 -0.372 1.0 1.0 IGF-1R heterotetramer/IGF1 0.009 0.095 -9999.0 0.0 -0.142 16.0 16.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.033 0.033 -9999.0 0.0 -0.196 1.0 1.0 MET 0.005 0.088 0.184 1.0 -0.283 5.0 6.0 PLEKHA7 -0.035 0.064 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.051 0.049 -9999.0 0.0 -0.152 2.0 2.0 establishment of epithelial cell apical/basal polarity -0.037 0.074 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.02 0.09 -9999.0 0.0 -0.169 16.0 16.0 regulation of cell-cell adhesion -0.049 0.065 -9999.0 0.0 -0.254 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.02 0.09 -9999.0 0.0 -0.17 16.0 16.0