Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Chi-square test_P	Chi-square test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
BRAF	59 (56%)	46	0.038258	1	0.2425	1	0.079392	1	0.41689	1	0.27419	1	0.13861	1	0.11708	1	0.49353	1
CDKN2A	16 (15%)	89	0.31018	1	0.97931	1	0.87428	1	0.039964	1	0.33148	1	0.4603	1	0.15728	1	0.31011	1
NRAS	29 (28%)	76	0.022772	1	0.050226	1	0.072044	1	0.50451	1	0.57351	1	0.4951	1	0.44367	1	0.71033	1
STK19	7 (7%)	98	0.43724	1	0.53431	1	0.1288	1	0.35819	1	0.14462	1	0.057629	1	0.031861	1	0.71286	1
TTN	83 (79%)	22	0.97325	1	0.80267	1	0.34361	1	0.23647	1	0.71902	1	0.7385	1	0.27628	1	0.57068	1
TP53	18 (17%)	87	0.12755	1	0.081277	1	0.48871	1	0.69944	1	0.10326	1	0.042113	1	0.0043607	1	0.077007	1
PTEN	11 (10%)	94	0.45902	1	0.17479	1	0.3868	1	0.10528	1	0.55868	1	0.13645	1	0.24979	1	0.70115	1
TPTE	29 (28%)	76	0.48109	1	0.58706	1	0.82191	1	0.20592	1	0.49241	1	0.95165	1	0.48067	1	1	1
PRB4	15 (14%)	90	0.13946	1	0.92172	1	0.24949	1	0.1538	1	0.40946	1	0.68932	1	0.52176	1	0.46954	1
CDH9	22 (21%)	83	0.68764	1	0.24	1	0.9186	1	0.66678	1	0.36788	1	0.52531	1	0.081096	1	0.70527	1
SERPINB4	17 (16%)	88	0.72417	1	0.63365	1	0.088566	1	0.01626	1	0.79475	1	0.81031	1	0.49072	1	0.50391	1
PRB2	19 (18%)	86	0.78815	1	0.76349	1	0.35981	1	0.94334	1	0.8551	1	0.21024	1	0.031162	1	0.060868	1
TCEB3C	14 (13%)	91	0.18381	1	0.062089	1	0.89818	1	0.47236	1	0.25468	1	0.5956	1	0.57425	1	0.1395	1
ADH1C	17 (16%)	88	0.86059	1	0.76054	1	0.10275	1	0.60658	1	0.019065	1	0.024102	1	0.78793	1	0.18694	1
C15ORF23	7 (7%)	98	0.26072	1	0.58651	1	0.86903	1	0.76277	1	0.47756	1	0.2997	1	0.78585	1	0.5746	1
CCNE2	10 (10%)	95	1	1	0.3135	1	0.17096	1	0.085374	1	0.83975	1	0.64763	1	0.3994	1	0.77265	1
SDR16C5	16 (15%)	89	0.89501	1	0.042233	1	0.053443	1	0.40637	1	0.051522	1	0.0090071	1	0.50372	1	0.91922	1
PDE1A	19 (18%)	86	0.90063	1	0.53962	1	0.64076	1	0.85245	1	0.8551	1	0.41297	1	0.4435	1	0.4102	1
TLL1	24 (23%)	81	0.58424	1	0.73258	1	0.46184	1	0.046834	1	0.29805	1	0.33614	1	0.57644	1	0.10004	1
RAC1	7 (7%)	98	0.95037	1	0.85711	1	0.85684	1	0.85804	1	1	1	0.86915	1	1	1	0.4523	1
RERG	8 (8%)	97	1	1	1	1	0.024967	1	0.72072	1	0.3354	1	0.46708	1	0.35631	1	0.16056	1
OR52L1	12 (11%)	93	0.52806	1	0.34312	1	0.07802	1	0.16476	1	0.31601	1	0.12131	1	0.85689	1	0.34893	1
HBD	8 (8%)	97	0.056516	1	1	1	0.25991	1	0.31549	1	0.23843	1	0.14152	1	0.23017	1	0.16056	1
VEGFC	12 (11%)	93	0.39444	1	0.52744	1	0.086464	1	0.14098	1	0.15999	1	0.014384	1	0.081606	1	0.033402	1
BAGE2	7 (7%)	98	0.35438	1	0.26363	1	0.66139	1	0.92737	1	0.25299	1	0.22919	1	0.52356	1	0.5746	1
OR1N2	13 (12%)	92	0.54837	1	0.33679	1	0.25395	1	0.35305	1	0.65144	1	0.74084	1	1	1	0.20696	1
PPP6C	10 (10%)	95	0.52092	1	0.84954	1	0.32314	1	0.507	1	0.54032	1	0.96557	1	0.12137	1	0.23656	1
HNF4G	12 (11%)	93	0.85892	1	1	1	0.7437	1	0.50429	1	1	1	0.9262	1	1	1	0.45399	1
TRAT1	6 (6%)	99	0.42943	1	0.4918	1	0.69961	1	0.72719	1	0.10327	1	0.22185	1	0.37299	1	0.32586	1
AREG	5 (5%)	100	0.86377	1	0.64432	1	0.49554	1	1	1	0.36545	1	0.52913	1	0.84003	1	1	1
ST18	24 (23%)	81	1	1	0.81545	1	0.55931	1	0.32679	1	0.4083	1	0.86286	1	0.43732	1	0.55432	1
TAF1A	8 (8%)	97	0.2838	1	0.3751	1	0.31897	1	0.48745	1	0.40975	1	0.57918	1	0.64009	1	0.86821	1
GRXCR2	9 (9%)	96	0.084324	1	0.16778	1	0.44698	1	1	1	0.10307	1	0.26143	1	0.13649	1	0.3376	1
OR9K2	11 (10%)	94	0.66319	1	0.30483	1	0.41355	1	0.022122	1	0.72258	1	0.60556	1	0.20828	1	1	1
OXA1L	4 (4%)	101	0.32776	1	0.30606	1	NA	NA	NA	NA	0.83259	1	0.91274	1	0.83429	1	0.26055	1
A2BP1	14 (13%)	91	0.72927	1	0.84485	1	0.022833	1	0.72256	1	0.27259	1	0.28022	1	0.06747	1	0.4965	1
HIST1H2AA	5 (5%)	100	0.61183	1	0.64432	1	0.6376	1	0.45295	1	0.43738	1	0.9352	1	0.73066	1	0.61564	1
LILRA1	21 (20%)	84	0.26419	1	0.48977	1	0.75927	1	0.30969	1	0.41338	1	0.76851	1	0.73917	1	0.80822	1
LIN7A	8 (8%)	97	0.42393	1	0.01512	1	0.47645	1	0.66372	1	0.23843	1	0.33634	1	0.64009	1	0.73842	1
VGLL1	3 (3%)	102	1	1	0.66796	1	NA	NA	NA	NA	1	1	1	1	0.79388	1	1	1
GALNTL5	10 (10%)	95	0.12537	1	0.19533	1	0.28879	1	0.10403	1	0.13093	1	0.3722	1	0.21474	1	0.77265	1
HSD11B1	6 (6%)	99	0.71223	1	0.60196	1	0.23352	1	0.28049	1	0.76388	1	1	1	0.1199	1	0.66226	1
ANKRD20A4	4 (4%)	101	0.36102	1	0.90058	1	0.098212	1	0.29627	1	0.83259	1	0.41459	1	0.67667	1	0.72517	1
GPR141	8 (8%)	97	0.38448	1	0.47325	1	0.0029748	1	0.017325	1	0.30088	1	0.34773	1	0.51181	1	1	1
NAP1L2	10 (10%)	95	0.38569	1	1	1	0.40241	1	0.13921	1	0.83975	1	0.78268	1	0.63804	1	1	1
C18ORF26	13 (12%)	92	0.18119	1	0.64209	1	0.62212	1	0.058724	1	1	1	0.41885	1	0.27849	1	0.42783	1
DEFB110	5 (5%)	100	0.70196	1	0.74408	1	0.10337	1	0.131	1	0.36545	1	0.28775	1	0.63182	1	1	1
IDH1	6 (6%)	99	0.31291	1	0.60196	1	0.12141	1	0.40476	1	0.76388	1	0.55119	1	0.50221	1	0.097239	1
SNAP91	15 (14%)	90	0.58951	1	0.0017161	1	0.93328	1	1	1	0.16161	1	0.26837	1	1	1	0.46954	1
CA1	6 (6%)	99	0.0098705	1	0.14218	1	0.75074	1	0.73279	1	0.38587	1	0.27065	1	0.045971	1	0.17555	1
SERPINB11	12 (11%)	93	0.12943	1	0.47847	1	0.87235	1	0.94678	1	0.29174	1	0.060576	1	0.79006	1	0.51009	1
UGT2B15	13 (12%)	92	0.89003	1	0.2843	1	0.92353	1	0.4072	1	1	1	0.85245	1	0.59595	1	0.08923	1
ACSM2B	21 (20%)	84	0.76946	1	0.049684	1	0.23611	1	0.16555	1	0.55577	1	0.20731	1	0.0069654	1	0.15526	1
C16ORF78	8 (8%)	97	0.019928	1	0.49029	1	0.87025	1	0.27033	1	0.8142	1	0.7895	1	0.23017	1	0.61428	1
TFEC	10 (10%)	95	0.82755	1	0.5587	1	0.15386	1	0.20561	1	0.91792	1	0.27466	1	0.57606	1	0.18985	1
TRHDE	24 (23%)	81	0.78773	1	0.0062651	1	0.79762	1	0.057971	1	0.53636	1	0.59975	1	0.79689	1	0.14409	1
OR5AC2	13 (12%)	92	0.74156	1	0.86935	1	0.6471	1	0.62425	1	0.20456	1	0.024627	1	1	1	0.89629	1
CCDC102B	11 (10%)	94	0.056017	1	0.6287	1	0.72225	1	0.18029	1	0.26195	1	0.60556	1	0.22842	1	0.31593	1
GRXCR1	12 (11%)	93	0.31086	1	0.20199	1	0.94861	1	0.48505	1	1	1	0.9262	1	0.53809	1	0.79114	1
OR4M2	13 (12%)	92	0.72631	1	0.12474	1	0.77884	1	0.66604	1	0.52606	1	0.60086	1	0.18513	1	0.89629	1
PLAC8L1	3 (3%)	102	0.18655	1	0.86297	1	0.17066	1	1	1	0.25936	1	0.18326	1	0.79388	1	1	1
POM121	10 (10%)	95	0.75823	1	0.36586	1	0.51723	1	0.2722	1	0.76581	1	0.73792	1	0.3994	1	0.38799	1
RBM11	9 (9%)	96	0.89457	1	0.37843	1	0.71542	1	0.62948	1	1	1	0.83533	1	0.67343	1	0.56245	1
RUNX1T1	16 (15%)	89	0.16804	1	0.53309	1	0.010346	1	0.040302	1	1	1	0.4603	1	0.57542	1	0.84228	1
RGS7	17 (16%)	88	0.64981	1	0.5439	1	0.79472	1	0.70116	1	0.37617	1	0.3142	1	0.38533	1	0.92285	1
CLVS2	11 (10%)	94	0.38574	1	0.68516	1	0.31897	1	0.62948	1	0.21585	1	0.26258	1	1	1	0.70115	1
DEFB118	6 (6%)	99	0.023716	1	0.4918	1	0.43951	1	0.60402	1	0.38587	1	0.79117	1	0.64488	1	1	1
OR52A5	12 (11%)	93	0.64694	1	0.0030218	1	0.080531	1	0.57499	1	0.088556	1	0.010426	1	0.92744	1	0.45399	1
SPTLC3	13 (12%)	92	0.53898	1	0.57274	1	0.78663	1	0.93488	1	0.035897	1	0.60086	1	0.41361	1	0.89629	1
ACTL7B	7 (7%)	98	0.20271	1	1	1	0.71199	1	0.68216	1	0.69254	1	0.45437	1	0.88539	1	0.85324	1
PHGDH	7 (7%)	98	0.6982	1	0.61282	1	0.70771	1	0.68216	1	0.37576	1	1	1	0.4713	1	0.4523	1
RGPD3	18 (17%)	87	0.15636	1	0.32113	1	0.56546	1	0.56414	1	0.45821	1	0.16579	1	0.42811	1	0.56101	1
WDR12	7 (7%)	98	0.6982	1	0.95106	1	0.71199	1	0.41497	1	0.69254	1	0.10812	1	0.054996	1	0.056697	1
MPP7	13 (12%)	92	0.48652	1	0.35967	1	0.62212	1	0.50613	1	0.33446	1	0.1491	1	0.929	1	1	1