rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(7), CCNE1(1), CCNE2(10), CDK4(2), CDKN2A(16), E2F1(5), E2F2(1), PRB1(14) 1394347 56 41 49 8 29 0 1 12 14 0 0.000507 2.24e-05 0.0102 2 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BRAF(64), CREB5(7), MAPK1(2), RAF1(2), SNX13(1) 1725227 76 63 26 18 21 3 2 50 0 0 0.126 3.31e-05 0.0102 3 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CDK4(2), CDKN1A(1), CDKN2A(16), E2F1(5), E2F2(1), MDM2(2), NXT1(2), PRB1(14), TP53(20) 1308030 63 38 57 10 29 2 2 9 21 0 0.000269 0.000389 0.0799 4 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(4), IL8(1), SLPI(5) 265596 10 10 10 2 4 1 0 4 1 0 0.226 0.0439 1.000 5 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(3), FOSB(5), GRIA2(19) 561071 27 21 24 7 21 1 0 3 2 0 0.0444 0.152 1.000 6 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(6) 110886 6 6 6 2 6 0 0 0 0 0 0.326 0.332 1.000 7 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(1), MYC(2), SP1(3), SP3(1), TP53(20), WT1(4) 1095688 31 23 29 5 14 1 4 4 8 0 0.0238 0.333 1.000 8 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(3), ALDH1A2(8), BCMO1(9), RDH5(1) 601941 21 18 20 5 13 2 1 3 2 0 0.0369 0.382 1.000 9 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(5), DCN(11), FMOD(3), KERA(10), LUM(7) 538277 36 22 36 13 30 3 1 1 1 0 0.0212 0.496 1.000 10 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3) 869053 64 39 58 17 49 4 4 5 2 0 0.00397 0.614 1.000 11 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 EHHADH(5), HADHA(7) 747324 12 11 11 4 8 1 0 3 0 0 0.289 0.640 1.000 12 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(4), CHRNA1(1), SNAP25(5), STX1A(2) 505419 12 9 10 3 8 0 0 1 3 0 0.114 0.688 1.000 13 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(4), CD3E(2) 173837 6 4 6 2 5 0 0 0 1 0 0.415 0.700 1.000 14 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(3), HADHA(7) 847363 12 10 12 2 6 1 1 4 0 0 0.180 0.765 1.000 15 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 79550 1 1 1 1 1 0 0 0 0 0 0.896 0.820 1.000 16 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(2) 256036 2 2 2 1 1 0 0 1 0 0 0.741 0.846 1.000 17 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(3), CDKN2A(16), E2F1(5), MDM2(2), MYC(2), PIK3CA(2), PIK3R1(2), POLR1A(7), POLR1B(4), POLR1C(1), RAC1(7), RB1(3), TBX2(1), TP53(20), TWIST1(1) 3124280 76 43 67 15 41 3 2 8 20 2 0.000481 0.878 1.000 18 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(2), CASP8(1), CFLAR(3), PDE6D(2) 603846 8 7 8 3 3 1 2 2 0 0 0.473 0.884 1.000 19 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 EHHADH(5), HADHA(7), HSD17B10(1), HSD17B4(3), NTAN1(1), SIRT2(1), SIRT5(4), SIRT7(2), VNN2(7) 1824715 31 22 30 6 20 3 3 5 0 0 0.0189 0.887 1.000 20 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(2), MTMR2(1), MTMR6(2), NFS1(3), TPK1(3) 984451 12 11 12 1 9 1 1 0 1 0 0.0473 0.904 1.000 21 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(1), EHHADH(5), GCDH(3), HADHA(7) 1205056 16 13 15 3 11 2 0 3 0 0 0.0700 0.908 1.000 22 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(1), PSMB4(1), PSMB5(1), PSMB7(1), PSMB8(1) 1362190 14 11 14 1 7 2 2 1 2 0 0.0319 0.922 1.000 23 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(2) 239595 2 1 2 0 0 1 0 0 1 0 0.527 0.969 1.000 24 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(1), HMGCL(2), OXCT1(3) 518476 6 6 6 2 4 0 0 1 1 0 0.489 0.971 1.000 25 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(2), TGDS(1), UXS1(1) 596534 4 4 4 3 1 0 0 0 3 0 0.935 0.973 1.000 26 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYB(1), RB1(3), SP1(3), SP3(1) 1028377 9 8 9 3 1 1 1 2 2 2 0.586 0.973 1.000 27 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 HADHA(7), HADHB(2), HSD17B10(1), HSD17B4(3), MECR(1), PPT1(3), PPT2(3) 1307025 20 18 20 6 8 2 3 6 1 0 0.279 0.974 1.000 28 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(3), IFNG(2), IL12A(2), IL12B(3), IL18(2), IL2(4) 452751 16 7 16 5 11 2 0 1 2 0 0.152 0.976 1.000 29 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(1), CDC34(3), CUL1(2), E2F1(5), FBXW7(7), RB1(3) 1250998 21 17 21 8 10 2 1 2 4 2 0.355 0.982 1.000 30 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(4), GOT2(2), TAT(10) 406648 16 9 16 5 13 0 2 1 0 0 0.112 0.984 1.000 31 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(2), ALDOA(1), ALDOB(5), ALDOC(1) 609799 9 6 9 3 6 0 0 1 2 0 0.237 0.984 1.000 32 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNG(2), IFNGR1(3), JAK1(4), JAK2(6), PLA2G2A(1), PTPRU(11), REG1A(4), STAT1(2) 1757163 34 20 34 8 19 1 1 7 6 0 0.0303 0.985 1.000 33 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(4), SEC61A2(3), SRP19(1), SRP54(1), SRP68(5), SRP72(1), SRPR(2) 1182709 17 15 15 6 9 0 1 2 5 0 0.496 0.986 1.000 34 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(6), COASY(3), DPYD(33), DPYS(13), ENPP1(7), ENPP3(8), PANK2(1), PANK3(1), PANK4(2), PPCS(3), UPB1(3) 2137161 80 40 74 22 65 4 3 4 4 0 0.00229 0.990 1.000 35 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(5), GGT1(3), SHMT2(2) 623386 10 9 10 5 8 0 0 1 1 0 0.359 0.990 1.000 36 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(3), ACTR2(2), ARPC1B(1), ARPC2(1), ARPC3(1), RAC1(7), WASF1(1), WASL(1) 1251808 17 14 14 4 13 0 1 1 2 0 0.133 0.992 1.000 37 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(3), RAB11A(1), RAB27A(2), RAB3A(2) 650036 8 6 8 2 7 0 1 0 0 0 0.223 0.992 1.000 38 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(2), SQLE(1) 491645 3 3 3 1 2 0 0 1 0 0 0.591 0.993 1.000 39 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(2), TGDS(1), UGP2(1), UXS1(1) 760505 5 5 5 4 2 0 0 0 3 0 0.942 0.994 1.000 40 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(6), BCAT2(1), COASY(3), DPYD(33), DPYS(13), ENPP1(7), ENPP3(8), ILVBL(2), PANK2(1), PANK3(1), PANK4(2), PPCS(3), UPB1(3), VNN1(4) 2650685 87 41 81 22 70 4 3 5 5 0 0.000219 0.994 1.000 41 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 CBS(3), MUT(4) 786471 7 7 7 3 5 0 0 1 1 0 0.567 0.996 1.000 42 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(2), GBA3(5), GGT1(3), SHMT2(2) 823959 13 10 13 5 11 0 0 1 1 0 0.209 0.997 1.000 43 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(7), CCNE1(1), CDC34(3), CUL1(2), E2F1(5), RB1(3) 1311595 21 18 21 9 14 2 0 1 2 2 0.331 0.997 1.000 44 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(3) 478029 5 5 5 4 2 0 1 1 1 0 0.824 0.998 1.000 45 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PLCD1(2), PRKCA(5), TGM2(4) 765949 12 7 12 5 8 2 0 0 2 0 0.167 0.998 1.000 46 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(1), CUL1(2), E2F1(5), RB1(3), UBE2M(1) 1325895 12 11 12 8 5 2 0 1 2 2 0.772 0.998 1.000 47 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(4), CBS(3), GGT1(3), MARS(4), MARS2(3), MAT1A(4), MAT2B(1), PAPSS1(1), PAPSS2(2), SCLY(2), SEPHS1(3) 1925135 30 22 30 8 17 1 2 6 4 0 0.0447 0.998 1.000 48 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP7(3), DFFA(1), DFFB(2), GZMB(1), HMGB1(1), TOP2A(3), TOP2B(4) 1387495 15 10 15 3 9 1 3 1 1 0 0.147 0.999 1.000 49 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(1), NFKBIA(1), PLCB1(29), PRKCA(5), RELA(1) 1258865 38 26 37 13 32 1 1 2 2 0 0.0922 0.999 1.000 50 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), CYCS(1), GPD2(1), SDHA(1), SDHC(2), UQCRC1(1) 1025912 7 7 7 1 5 0 1 1 0 0 0.186 0.999 1.000 51 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(6), LPL(2), NR3C1(1), PPARG(6), RETN(3), RXRA(1), TNF(1) 898972 20 16 19 8 13 2 0 3 2 0 0.223 0.999 1.000 52 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF2(2), CSF3(1), EPO(4), FLT3(18), IGF1(6), IL11(2), IL1A(2), IL3(2), KITLG(6), TGFB2(1), TGFB3(1) 1265622 45 26 43 14 34 2 2 2 5 0 0.0117 0.999 1.000 53 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(7), CCND2(3), CCNE1(1), CCNH(1), CDC25A(5), CDK4(2), CDKN1A(1), CDKN2A(16), E2F1(5), RB1(3), RBL1(4) 2497998 48 35 44 15 25 1 1 5 14 2 0.0547 0.999 1.000 54 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(5), GOT1(4), GOT2(2), LDHA(2), LDHC(1), MPST(1) 1060191 15 12 15 5 12 0 3 0 0 0 0.181 0.999 1.000 55 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(6), IARS(1), LARS(8), LARS2(3), PDHA1(1), PDHA2(7), PDHB(1) 1553920 27 17 26 6 21 2 0 2 2 0 0.0547 0.999 1.000 56 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(5), EPHX2(4), RDH12(1), RDH13(3) 742692 13 10 13 9 10 0 1 0 2 0 0.571 1.000 1.000 57 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(7), CSF2(2), HLA-DRA(5), IL3(2), IL5(4) 466138 20 12 19 10 17 1 0 1 1 0 0.172 1.000 1.000 58 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(3), IFNGR2(2), JAK1(4), JAK2(6), STAT1(2) 1258167 19 11 19 6 8 0 1 6 4 0 0.499 1.000 1.000 59 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(3), BAX(1), BCL10(1), BCL2(2), BCL2L11(2), CASP8AP2(3), CASP9(2), CES1(11) 1674482 25 15 25 5 21 2 0 0 2 0 0.0324 1.000 1.000 60 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(3), AASDH(4), AASDHPPT(1), AASS(1), KARS(2) 1061593 11 9 11 4 9 0 0 1 1 0 0.496 1.000 1.000 61 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(5), CASP8(1), RIPK1(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(1) 1261204 13 11 13 4 9 1 1 1 1 0 0.189 1.000 1.000 62 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 IFNG(2), IFNGR1(3), IFNGR2(2), IKBKB(2), JAK2(6), LIN7A(10), NFKB1(1), NFKBIA(1), RB1(3), RELA(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TP53(20), USH1C(9), WT1(4) 2781809 68 37 65 19 32 3 4 12 15 2 0.0231 1.000 1.000 63 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(1), PAPSS2(2), SULT1E1(7), SULT2A1(4), SUOX(2) 942016 16 7 16 6 11 0 0 2 3 0 0.334 1.000 1.000 64 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(5), CDC25B(1), CDKN1A(1), CHEK1(1), NEK1(5) 1068460 13 10 13 4 8 1 1 1 2 0 0.410 1.000 1.000 65 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(2), ACAT2(1), EHHADH(5), HADHA(7), HADHB(2) 1289658 17 15 16 6 11 2 0 3 1 0 0.352 1.000 1.000 66 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(4), B3GNT1(1), FUT1(3), FUT2(1), FUT9(13) 918368 22 19 22 10 16 3 1 2 0 0 0.208 1.000 1.000 67 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(4), POLR2A(8), POLR2B(10), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2L(1), POLRMT(1) 2056161 29 23 29 9 18 3 1 4 3 0 0.0957 1.000 1.000 68 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 DAG1(3), GNAQ(1), ITPKB(4) 923493 8 8 8 4 6 0 1 0 1 0 0.467 1.000 1.000 69 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(2), SQLE(1) 657079 3 3 3 2 2 0 0 1 0 0 0.787 1.000 1.000 70 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(16), GNAS(12), PRKACA(2), PRKAR1A(1) 997641 31 20 31 10 21 2 2 3 3 0 0.0705 1.000 1.000 71 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(1), ERBB4(26), NRG2(4), NRG3(10), PRKCA(5) 1370159 46 33 44 15 34 3 2 4 3 0 0.0710 1.000 1.000 72 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLS2(3), GLUD1(1) 699968 5 3 5 5 3 1 0 0 1 0 0.884 1.000 1.000 73 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(3), ATM(8), BAX(1), BCL2(2), CCNE1(1), CDK4(2), CDKN1A(1), E2F1(5), MDM2(2), PCNA(1), RB1(3), TIMP3(3), TP53(20) 2771782 52 34 49 14 24 4 1 8 13 2 0.0755 1.000 1.000 74 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(4), BHMT(6), CBS(3), DNMT1(10), DNMT3A(5), DNMT3B(8), MARS(4), MARS2(3), MAT1A(4), MAT2B(1), MTR(5) 2720743 53 30 52 12 32 2 3 8 8 0 0.00304 1.000 1.000 75 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(3), BAX(1), BCL2(2), BIRC2(4), BIRC3(5), CASP7(3), CASP8(1), CASP9(2), CYCS(1), DFFA(1), DFFB(2), DIABLO(1) 2079623 26 19 26 7 15 3 4 3 1 0 0.0915 1.000 1.000 76 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(4), ICAM1(2), ITGAL(15), ITGAM(14), ITGB2(8), SELE(19), SELL(5) 1573432 67 31 67 23 56 2 1 2 6 0 0.00478 1.000 1.000 77 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(4), GNAQ(1), HTR2C(5), PLCB1(29), TUB(5) 1098691 44 28 43 18 38 0 0 3 3 0 0.0786 1.000 1.000 78 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(1), PSMB4(1), PSMB5(1), PSMB7(1), PSMC2(1), PSMC3(1), PSMD1(3), PSMD12(1), PSMD13(2), PSMD2(1) 2489995 22 19 21 7 13 2 2 3 2 0 0.252 1.000 1.000 79 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ASL(2), CPS1(12), GLS(1), GLUD1(1), GOT1(4) 1169207 20 11 20 8 14 2 2 2 0 0 0.307 1.000 1.000 80 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(4), CD3D(4), CD3E(2), GZMB(1), HLA-A(1), ICAM1(2), ITGAL(15), ITGB2(8), PRF1(5) 1337593 42 23 41 18 29 4 0 1 8 0 0.0781 1.000 1.000 81 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(1), BMPR1A(1), BMPR1B(2), BMPR2(3) 968453 7 7 7 6 6 0 0 0 1 0 0.872 1.000 1.000 82 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(1), PSMB4(1), PSMB5(1), PSMB7(1), PSMC3(1), PSMD14(1), RPN2(2), UBE3A(5) 2004824 22 18 22 9 13 3 1 3 2 0 0.434 1.000 1.000 83 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(2), ACP2(2), ACP5(2), ACP6(7), ACPP(4), ENPP1(7), ENPP3(8), FLAD1(6), LHPP(1), MTMR1(2), MTMR2(1), MTMR6(2), TYR(2) 2305297 46 29 45 14 28 2 5 4 7 0 0.0808 1.000 1.000 84 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(5), CHAT(10), CHKA(2), PCYT1A(2), PDHA1(1), PDHA2(7), PEMT(1), SLC18A3(2) 1059833 30 19 30 12 26 1 0 1 2 0 0.0748 1.000 1.000 85 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(3), APAF1(3), BCL2(2), CASP9(2), CYCS(1), DAXX(4), FAS(3), FASLG(10), HSPB1(1), HSPB2(1), IL1A(2), MAPKAPK2(2), MAPKAPK3(1), TNF(1) 1753277 36 24 36 12 26 2 0 1 7 0 0.0418 1.000 1.000 86 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(1), CS(1), FH(3), MDH1(1), OGDH(7), SDHA(1) 1461783 14 13 14 9 10 0 2 0 2 0 0.701 1.000 1.000 87 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(10), AOC2(5), AOC3(5), CES1(11), ESD(1) 926989 32 24 32 15 29 1 2 0 0 0 0.155 1.000 1.000 88 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(5), ST3GAL5(1), ST6GALNAC2(2) 875043 9 9 9 5 7 1 1 0 0 0 0.470 1.000 1.000 89 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(4), CLOCK(2), CRY1(3), CRY2(1), CSNK1E(3), PER1(2) 1297149 15 11 15 7 11 0 1 2 1 0 0.611 1.000 1.000 90 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(10), RANGAP1(2) 1314992 12 12 12 5 8 2 0 0 2 0 0.642 1.000 1.000 91 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(3), AASDHPPT(1), AASS(1), KARS(2) 714425 7 7 7 4 6 0 0 1 0 0 0.766 1.000 1.000 92 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP2(3), MMP9(5), RECK(3), TIMP2(1), TIMP3(3), TIMP4(2) 1144255 17 13 17 8 11 1 0 4 1 0 0.465 1.000 1.000 93 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(9), NR0B2(5), NR1H3(2), NR1H4(8), RXRA(1) 839763 25 15 25 10 17 4 2 0 2 0 0.107 1.000 1.000 94 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(5), FDPS(2), HMGCR(7), LSS(2), MVK(1), NQO1(1), PMVK(1), SQLE(1) 1694086 20 14 19 8 10 3 0 5 2 0 0.349 1.000 1.000 95 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2) 2035296 78 43 72 28 57 6 5 5 5 0 0.0103 1.000 1.000 96 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3D(4), CD3E(2), IFNG(2), IL2(4), IL2RA(4), IL4(1), TGFB2(1), TGFB3(1), TGFBR2(5), TGFBR3(4), TOB1(2), TOB2(2) 1618392 32 20 32 10 25 1 0 0 6 0 0.0441 1.000 1.000 97 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(3), CD8A(1), CSF1(7), CSF2(2), CSF3(1), EPO(4), IL11(2), IL2(4), IL3(2), IL4(1), IL5(4), IL7(3), IL8(1) 930400 35 19 34 19 26 3 0 2 4 0 0.178 1.000 1.000 98 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(3), ALAS2(2), CPOX(2), FECH(1), HMBS(1), PPOX(2), UROS(1) 1164342 12 10 12 5 10 1 0 0 1 0 0.337 1.000 1.000 99 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(1), CDC25A(5), CDC25B(1), CDC25C(3), MNAT1(2), SHH(2) 1345743 14 11 14 6 11 0 1 2 0 0 0.497 1.000 1.000 100 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(5), CS(1), MDH1(1), ME1(11), PC(5), PDHA1(1), SLC25A11(1) 1435147 25 15 25 12 16 3 1 3 2 0 0.299 1.000 1.000 101 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(4), PARK2(2), SNCAIP(28), UBE2E2(2), UBE2F(3), UBE2L6(1) 991685 40 25 35 14 31 5 0 3 1 0 0.128 1.000 1.000 102 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 11 ALAD(3), ALAS2(2), FECH(1), GATA1(1), HBB(5), HMBS(1), UROS(1) 1170845 14 11 13 9 12 1 0 0 1 0 0.562 1.000 1.000 103 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFB6(2), NDUFS2(1) 1079480 3 3 3 5 2 0 0 0 1 0 0.985 1.000 1.000 104 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(8), CYP2E1(8), NR1I3(5), PTGS1(12), PTGS2(6) 832500 39 23 39 20 30 1 0 3 5 0 0.204 1.000 1.000 105 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), FPGS(3), GGH(1), SPR(1) 977530 22 15 22 11 16 3 2 0 1 0 0.218 1.000 1.000 106 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(12), DAXX(4), PAX3(2), PML(1), RB1(3), SP100(5), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TP53(20) 2892451 51 31 49 17 24 5 4 5 11 2 0.131 1.000 1.000 107 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(3), CYSLTR2(2), GPR109B(7), GPR161(4), GPR171(4), GPR39(7), GPR45(4), GPR65(5), GPR68(2), GPR75(3), GPR81(3) 1504168 44 26 43 20 35 2 2 0 5 0 0.00520 1.000 1.000 108 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(3), ACSL1(2), ACSL3(3), CPT1A(6), CPT2(1), DCI(2), EHHADH(5), HADHA(7) 2614711 31 25 28 11 21 1 2 4 3 0 0.211 1.000 1.000 109 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(4), BHMT(6), CBS(3), DNMT1(10), DNMT3A(5), DNMT3B(8), MARS(4), MARS2(3), MAT1A(4), MAT2B(1), MTAP(3), MTFMT(1), MTR(5), TAT(10) 3231601 67 31 66 18 42 3 4 10 8 0 0.00398 1.000 1.000 110 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(3), ATM(8), ATR(13), CCNA1(7), CCNE1(1), CDC25A(5), CDK4(2), CDKN1A(1), CDKN2A(16), E2F1(5), GSK3B(1), HDAC1(1), RB1(3), TGFB2(1), TGFB3(1), TP53(20) 4645258 88 52 81 28 46 2 5 9 24 2 0.0424 1.000 1.000 111 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(13), CD3D(4), CD3E(2), CD8A(1), ICAM1(2), ITGAL(15), ITGB2(8), PTPRC(18) 1627399 63 30 58 28 51 2 0 3 7 0 0.0509 1.000 1.000 112 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(2), POLD2(1), POLE(9), POLG(4), POLL(6), POLQ(12) 2574099 34 28 34 14 17 3 2 6 6 0 0.253 1.000 1.000 113 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(2), ACP2(2), ACP5(2), ACPP(4), ENPP1(7), ENPP3(8), FLAD1(6), TYR(2) 1487033 33 23 32 12 21 1 2 3 6 0 0.232 1.000 1.000 114 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(1), ACO2(1), FH(3), IDH1(6), MDH1(1), MDH2(1) 1385559 13 11 10 9 9 0 2 1 1 0 0.740 1.000 1.000 115 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(4), ASPH(2), COPS5(2), EDN1(6), EP300(7), EPO(4), JUN(1), LDHA(2), NOS3(11), P4HB(2), VHL(1) 2633308 42 27 40 14 29 3 3 3 4 0 0.132 1.000 1.000 116 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(1), DNAJC3(1), EIF2S1(1), MAP3K14(1), NFKB1(1), NFKBIA(1), RELA(1), TP53(20) 1493907 27 22 25 10 15 0 2 3 7 0 0.395 1.000 1.000 117 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(1), APAF1(3), ATM(8), BAX(1), BCL2(2), CASP7(3), CASP9(2), CYCS(1), EIF2S1(1), PRKCA(5), PTK2(2), PXN(3), STAT1(2), TLN1(10), TP53(20) 4199433 64 37 61 21 34 7 3 9 11 0 0.0614 1.000 1.000 118 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT2(2), B4GALT3(1), B4GALT5(1), FUT8(4), ST3GAL1(5) 1211097 14 11 14 9 10 2 1 0 1 0 0.580 1.000 1.000 119 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(4), ICAM1(2), ITGA4(18), ITGAL(15), ITGB1(3), ITGB2(8), SELE(19), SELL(5) 1833668 74 36 72 24 60 2 2 4 6 0 0.0167 1.000 1.000 120 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(4), ICAM1(2), ITGA4(18), ITGAL(15), ITGAM(14), ITGB1(3), ITGB2(8), SELE(19), SELL(5), SELP(13) 2413126 101 43 97 35 84 2 2 6 7 0 0.00757 1.000 1.000 121 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(10), CKM(1), GPT(3), LDHA(2), LDHC(1), MAPK14(4), NCL(3) 1384104 24 15 24 11 16 2 2 3 1 0 0.378 1.000 1.000 122 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(5), CDO1(2), GOT1(4), GOT2(2), LDHA(2), LDHAL6B(5), LDHC(1), MPST(1), SULT1B1(8), SULT1C2(1), SULT1C4(9), SULT4A1(5) 1935061 45 27 44 17 34 1 5 0 5 0 0.0671 1.000 1.000 123 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(4), JAK2(6), JAK3(5), PIAS1(2), PIAS3(3), PTPRU(11), REG1A(4), SOAT1(1) 2096480 37 27 37 14 24 2 2 5 4 0 0.142 1.000 1.000 124 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(2), FUT1(3), FUT2(1), FUT9(13), GBGT1(1), HEXA(4), HEXB(2), ST3GAL1(5) 1552502 31 19 31 16 24 3 0 4 0 0 0.253 1.000 1.000 125 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(4), IFNG(2), IL10(1), IL12A(2), IL12B(3), IL13(2), IL15(1), IL16(7), IL18(2), IL1A(2), IL2(4), IL3(2), IL4(1), IL5(4), IL8(1), LTA(2), TNF(1) 1523010 41 21 40 18 31 3 0 1 6 0 0.0519 1.000 1.000 126 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(2), GSR(2), GSS(3), IL8(1), NFKB1(1), NOX1(6), RELA(1), TNF(1), XDH(33) 1516442 50 25 50 23 39 2 4 3 2 0 0.106 1.000 1.000 127 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(6), BCAT2(1), IARS(1), IARS2(9), ILVBL(2), LARS(8), LARS2(3), PDHA1(1), PDHA2(7), PDHB(1), VARS(10), VARS2(4) 2911298 53 31 49 19 38 6 1 4 4 0 0.103 1.000 1.000 128 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(4), B3GNT1(1), B3GNT2(2), B3GNT3(3), B3GNT4(2), B3GNT5(1), B4GALT2(2), B4GALT3(1), FUT1(3), FUT2(1), FUT3(3), FUT4(1), FUT5(6), FUT6(1), FUT7(1), FUT9(13), ST3GAL6(2) 2452451 47 31 47 22 31 8 2 2 4 0 0.118 1.000 1.000 129 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(14), FOS(1), JUN(1), MAP2K1(3), MAPK1(2), MAPK3(1), MYC(2), NFKB1(1), NFKBIA(1), PLCB1(29), PRKCA(5), RAF1(2), RELA(1), TNF(1) 2397083 64 38 61 28 50 3 4 3 4 0 0.0952 1.000 1.000 130 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(4), CARM1(2), CBS(3), GGT1(3), HEMK1(1), LCMT1(3), MARS(4), MARS2(3), MAT1A(4), MAT2B(1), METTL2B(5), PAPSS1(1), PAPSS2(2), PRMT2(1), PRMT3(3), PRMT5(3), PRMT6(1), PRMT7(1), PRMT8(7), SCLY(2), SEPHS1(3), SEPHS2(1) 3864336 58 33 57 22 36 5 3 8 6 0 0.0722 1.000 1.000 131 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(2), ACP2(2), ACP5(2), ACP6(7), ACPP(4), ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), CMBL(1), CYP3A4(12), CYP3A43(8), CYP3A5(4), CYP3A7(12), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(2), PON1(8), PON2(1), PON3(4) 2756209 94 41 93 36 69 5 6 6 8 0 0.00654 1.000 1.000 132 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNB1(4), JAK1(4), PTPRU(11), REG1A(4), STAT1(2), STAT2(5), TYK2(3) 1927731 33 22 33 14 20 2 1 5 5 0 0.181 1.000 1.000 133 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(3), CREBBP(12), DFFA(1), DFFB(2), GZMA(6), GZMB(1), PRF1(5), SET(2) 1636976 32 17 32 13 19 2 4 3 4 0 0.350 1.000 1.000 134 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(3), ACVR1C(7), AKT1(1), AKT2(6), AKT3(2), ARRB1(1), ARRB2(3), ATF2(5), ATF4(4), BDNF(2), BRAF(64), CACNA1A(19), CACNA1B(18), CACNA1C(27), CACNA1D(17), CACNA1E(62), CACNA1F(13), CACNA1G(19), CACNA1H(14), CACNA1I(20), CACNA1S(26), CACNA2D1(8), CACNA2D2(7), CACNA2D3(28), CACNA2D4(12), CACNB1(1), CACNB2(4), CACNB3(2), CACNB4(7), CACNG1(2), CACNG2(3), CACNG3(10), CACNG4(3), CACNG5(9), CACNG6(2), CACNG7(1), CD14(3), CDC25B(1), CHP(1), CHUK(1), CRK(2), DAXX(4), DDIT3(1), DUSP10(6), DUSP14(1), DUSP16(1), DUSP4(1), DUSP5(2), DUSP6(1), DUSP7(1), DUSP8(1), ECSIT(1), EGF(14), EGFR(13), ELK4(4), FAS(3), FASLG(10), FGF11(2), FGF12(8), FGF13(3), FGF14(4), FGF17(1), FGF18(2), FGF19(2), FGF21(1), FGF23(3), FGF3(4), FGF4(1), FGF5(2), FGF6(1), FGF7(6), FGF8(1), FGF9(1), FGFR1(6), FGFR2(20), FGFR3(7), FGFR4(5), FLNA(5), FLNB(23), FLNC(31), FOS(1), GADD45B(1), GNA12(2), GRB2(2), IKBKB(2), IL1A(2), IL1B(2), IL1R1(6), IL1R2(5), JUN(1), KRAS(1), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAP2K5(2), MAP2K6(2), MAP2K7(2), MAP3K10(5), MAP3K12(2), MAP3K13(5), MAP3K14(1), MAP3K2(2), MAP3K3(3), MAP3K4(9), MAP3K5(9), MAP3K6(5), MAP4K1(3), MAP4K2(4), MAP4K3(4), MAP4K4(5), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(2), MAPK14(4), MAPK3(1), MAPK7(2), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1), MAPKAPK2(2), MAPKAPK3(1), MAPT(4), MEF2C(2), MKNK1(5), MKNK2(2), MOS(5), MYC(2), NF1(20), NFATC2(4), NFATC4(3), NFKB1(1), NFKB2(3), NLK(2), NR4A1(1), NRAS(29), NTF3(3), NTRK1(9), NTRK2(6), PAK1(2), PAK2(2), PDGFA(1), PDGFB(1), PDGFRA(13), PDGFRB(7), PLA2G12B(3), PLA2G2A(1), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(12), PLA2G4A(7), PLA2G6(7), PPM1A(1), PPM1B(5), PPP3CA(4), PPP3CB(1), PPP3R2(5), PPP5C(2), PRKACA(2), PRKACB(2), PRKACG(5), PRKCA(5), PRKCG(9), PRKX(1), PTPN5(7), PTPN7(1), PTPRR(18), RAC1(7), RAF1(2), RAP1A(1), RAPGEF2(6), RASA1(1), RASA2(9), RASGRF1(14), RASGRF2(6), RASGRP1(6), RASGRP2(2), RASGRP3(7), RASGRP4(7), RPS6KA1(2), RPS6KA2(4), RPS6KA4(2), RPS6KA5(3), RPS6KA6(3), RRAS(1), SOS1(4), SOS2(3), SRF(1), STK4(3), STMN1(1), TAOK1(8), TAOK2(18), TGFB2(1), TGFB3(1), TGFBR2(5), TNF(1), TNFRSF1A(2), TP53(20), TRAF2(1), TRAF6(2), ZAK(4) 43212047 1167 103 1060 607 766 100 39 159 101 2 0.0121 1.000 1.000 135 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ACTN1(2), ACTN2(14), ACTN3(5), ACTN4(2), APC(11), APC2(4), ARHGEF1(1), ARHGEF12(6), ARHGEF4(3), ARHGEF6(5), ARHGEF7(2), ARPC1B(1), ARPC2(1), ARPC3(1), BAIAP2(2), BCAR1(3), BDKRB1(4), BDKRB2(2), BRAF(64), CD14(3), CHRM1(4), CHRM2(7), CHRM3(10), CHRM4(4), CHRM5(1), CRK(2), CSK(1), CYFIP1(2), CYFIP2(15), DIAPH1(4), DIAPH2(2), DIAPH3(4), DOCK1(11), EGF(14), EGFR(13), EZR(1), F2(6), F2R(3), FGD1(2), FGD3(3), FGF11(2), FGF12(8), FGF13(3), FGF14(4), FGF17(1), FGF18(2), FGF19(2), FGF21(1), FGF23(3), FGF3(4), FGF4(1), FGF5(2), FGF6(1), FGF7(6), FGF8(1), FGF9(1), FGFR1(6), FGFR2(20), FGFR3(7), FGFR4(5), FN1(8), GIT1(4), GNA12(2), GNA13(1), GRLF1(3), GSN(3), IQGAP1(7), IQGAP2(13), IQGAP3(7), ITGA1(14), ITGA10(2), ITGA11(12), ITGA2(7), ITGA2B(6), ITGA3(4), ITGA4(18), ITGA5(11), ITGA6(5), ITGA7(15), ITGA8(22), ITGA9(9), ITGAD(16), ITGAE(8), ITGAL(15), ITGAM(14), ITGAV(4), ITGAX(10), ITGB1(3), ITGB2(8), ITGB3(7), ITGB4(11), ITGB6(8), ITGB7(3), ITGB8(9), KRAS(1), LIMK1(4), LIMK2(5), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK3(1), MOS(5), MYH10(5), MYH14(10), MYH9(6), MYL2(4), MYL9(1), MYLK(17), MYLK2(4), MYLPF(1), NCKAP1(1), NCKAP1L(20), NRAS(29), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PAK7(27), PDGFA(1), PDGFB(1), PDGFRA(13), PDGFRB(7), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PIP4K2A(3), PIP4K2B(2), PIP4K2C(1), PIP5K1A(6), PIP5K1B(11), PIP5K1C(4), PPP1CA(1), PPP1CB(3), PPP1CC(1), PPP1R12A(2), PPP1R12B(5), PTK2(2), PXN(3), RAC1(7), RAF1(2), ROCK1(2), ROCK2(4), RRAS(1), SCIN(3), SLC9A1(1), SOS1(4), SOS2(3), SSH1(8), SSH2(4), SSH3(3), TIAM1(20), TIAM2(17), TMSL3(2), VAV1(12), VAV2(3), VAV3(5), VCL(4), WAS(4), WASF1(1), WASF2(4), WASL(1) 42118470 993 101 898 481 676 54 41 155 64 3 0.00116 1.000 1.000 136 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(3), ACTG1(3), ACTN1(2), ACTN2(14), ACTN3(5), ACTN4(2), AKT1(1), AKT2(6), AKT3(2), ARHGAP5(7), BCAR1(3), BCL2(2), BIRC2(4), BIRC3(5), BRAF(64), CAPN2(2), CAV1(1), CCND2(3), CHAD(3), COL11A1(34), COL11A2(25), COL1A1(25), COL1A2(24), COL2A1(17), COL3A1(34), COL4A1(29), COL4A2(20), COL4A4(50), COL4A6(21), COL5A1(34), COL5A2(22), COL5A3(40), COL6A1(7), COL6A2(6), COL6A3(32), COL6A6(29), COMP(4), CRK(2), CTNNB1(5), DIAPH1(4), DOCK1(11), EGF(14), EGFR(13), ERBB2(2), FARP2(2), FIGF(4), FLNA(5), FLNB(23), FLNC(31), FLT1(17), FN1(8), FYN(4), GRB2(2), GRLF1(3), GSK3B(1), HGF(8), IBSP(4), IGF1(6), IGF1R(5), ITGA1(14), ITGA10(2), ITGA11(12), ITGA2(7), ITGA2B(6), ITGA3(4), ITGA4(18), ITGA5(11), ITGA6(5), ITGA7(15), ITGA8(22), ITGA9(9), ITGAV(4), ITGB1(3), ITGB3(7), ITGB4(11), ITGB6(8), ITGB7(3), ITGB8(9), JUN(1), KDR(22), LAMA1(21), LAMA2(24), LAMA3(31), LAMA4(4), LAMA5(17), LAMB1(6), LAMB2(5), LAMB3(17), LAMB4(20), LAMC1(8), LAMC2(10), LAMC3(6), MAP2K1(3), MAPK1(2), MAPK10(5), MAPK3(1), MAPK9(1), MET(7), MYL2(4), MYL9(1), MYLK(17), MYLK2(4), MYLPF(1), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PAK7(27), PARVA(1), PARVB(1), PARVG(1), PDGFA(1), PDGFB(1), PDGFC(12), PDGFD(2), PDGFRA(13), PDGFRB(7), PDPK1(1), PGF(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PIP5K1C(4), PPP1CA(1), PPP1CB(3), PPP1CC(1), PPP1R12A(2), PRKCA(5), PRKCG(9), PTEN(11), PTK2(2), PXN(3), RAC1(7), RAF1(2), RAP1A(1), RAPGEF1(3), RELN(42), ROCK1(2), ROCK2(4), SHC2(4), SHC3(7), SOS1(4), SOS2(3), SPP1(3), THBS1(15), THBS2(5), THBS3(7), THBS4(7), TLN1(10), TLN2(10), TNC(16), TNN(27), TNR(44), TNXB(65), VAV1(12), VAV2(3), VAV3(5), VCL(4), VEGFA(1), VEGFB(1), VEGFC(13), VTN(5), VWF(28), ZYX(3) 56940012 1689 99 1599 756 1257 105 47 173 105 2 0.000239 1.000 1.000 137 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(64), C7orf16(1), CACNA1A(19), CRH(2), CRHR1(1), GNA11(2), GNA12(2), GNA13(1), GNAI2(2), GNAO1(1), GNAQ(1), GNAS(12), GNAZ(3), GRIA1(28), GRIA2(19), GRIA3(15), GRID2(31), GRM1(7), GRM5(5), GUCY1A2(8), GUCY1A3(18), GUCY1B3(4), GUCY2C(16), GUCY2D(3), GUCY2F(7), IGF1(6), IGF1R(5), ITPR1(16), ITPR2(10), ITPR3(4), KRAS(1), LYN(1), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK3(1), NOS1(32), NOS3(11), NPR1(12), NPR2(11), NRAS(29), PLA2G12B(3), PLA2G2A(1), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(12), PLA2G4A(7), PLA2G6(7), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(2), PPP2R2C(4), PRKCA(5), PRKCG(9), PRKG1(5), PRKG2(8), RAF1(2), RYR1(52) 16712661 619 99 518 314 419 34 22 107 37 0 0.00469 1.000 1.000 138 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 BRAF(64), CD244(6), CD247(1), CD48(4), CHP(1), CSF2(2), FAS(3), FASLG(10), FCER1G(1), FCGR3A(3), FYN(4), GRB2(2), GZMB(1), HLA-A(1), HLA-B(4), HLA-C(1), HLA-G(3), ICAM1(2), ICAM2(4), IFNA10(1), IFNA14(4), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(6), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR2(3), IFNB1(4), IFNG(2), IFNGR1(3), IFNGR2(2), ITGAL(15), ITGB2(8), KIR2DL1(12), KIR2DL3(4), KIR2DL4(3), KIR3DL1(14), KIR3DL2(2), KLRC1(2), KLRC2(1), KLRC3(5), KLRD1(4), KLRK1(3), KRAS(1), LCK(4), LCP2(5), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK3(1), MICA(3), MICB(2), NCR1(8), NCR2(4), NCR3(2), NFAT5(3), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), NRAS(29), PAK1(2), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PLCG1(4), PLCG2(9), PPP3CA(4), PPP3CB(1), PPP3R2(5), PRF1(5), PRKCA(5), PRKCG(9), PTK2B(7), PTPN11(3), PTPN6(1), RAC1(7), RAF1(2), SH2D1A(2), SH2D1B(3), SH3BP2(2), SHC2(4), SHC3(7), SOS1(4), SOS2(3), SYK(9), TNF(1), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10C(3), TNFRSF10D(4), TNFSF10(5), TYROBP(2), ULBP1(2), ULBP3(3), VAV1(12), VAV2(3), VAV3(5), ZAP70(4) 17312069 502 98 417 207 321 31 23 102 25 0 0.00121 1.000 1.000 139 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(16), ADCY8(26), ATF4(4), BRAF(64), CACNA1C(27), CALM2(1), CALML3(3), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CAMK4(8), CHP(1), CREBBP(12), EP300(7), GNAQ(1), GRIA1(28), GRIA2(19), GRIN1(6), GRIN2A(48), GRIN2B(28), GRIN2C(6), GRIN2D(3), GRM1(7), GRM5(5), ITPR1(16), ITPR2(10), ITPR3(4), KRAS(1), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK3(1), NRAS(29), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), PPP1CA(1), PPP1CB(3), PPP1CC(1), PPP1R12A(2), PPP1R1A(2), PPP3CA(4), PPP3CB(1), PPP3R2(5), PRKACA(2), PRKACB(2), PRKACG(5), PRKCA(5), PRKCG(9), PRKX(1), RAF1(2), RAP1A(1), RAPGEF3(4), RPS6KA1(2), RPS6KA2(4), RPS6KA6(3) 15060467 525 98 436 267 334 37 22 103 29 0 0.0499 1.000 1.000 140 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(3), ABL2(6), AKT1(1), AKT2(6), AKT3(2), AREG(6), BRAF(64), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CBL(4), CBLB(7), CBLC(12), CDKN1A(1), CRK(2), EGF(14), EGFR(13), ERBB2(2), ERBB3(2), ERBB4(26), GAB1(3), GRB2(2), GSK3B(1), JUN(1), KRAS(1), MAP2K1(3), MAP2K2(2), MAP2K4(3), MAP2K7(2), MAPK1(2), MAPK10(5), MAPK3(1), MAPK9(1), MYC(2), NCK2(3), NRAS(29), NRG1(9), NRG2(4), NRG3(10), NRG4(1), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PAK7(27), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PLCG1(4), PLCG2(9), PRKCA(5), PRKCG(9), PTK2(2), RAF1(2), RPS6KB1(1), RPS6KB2(2), SHC2(4), SHC3(7), SOS1(4), SOS2(3), STAT5A(2), STAT5B(2), TGFA(1) 15726704 401 97 317 154 233 19 26 108 15 0 0.0108 1.000 1.000 141 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(12), ADORA1(1), ADORA2A(1), ADORA2B(1), ADORA3(10), ADRA1A(4), ADRA1B(1), ADRA2A(2), ADRA2B(4), ADRA2C(2), ADRB1(3), ADRB2(1), AGTR1(6), AGTR2(2), AVPR1A(2), AVPR1B(5), BDKRB1(4), BDKRB2(2), BRS3(2), C3AR1(2), C5AR1(4), CALCR(11), CALCRL(8), CCKAR(8), CCKBR(8), CHRM1(4), CHRM2(7), CHRM3(10), CHRM4(4), CHRM5(1), CNR1(7), CNR2(1), CRHR1(1), CRHR2(1), CTSG(4), CYSLTR1(3), CYSLTR2(2), DRD1(7), DRD2(8), DRD3(1), DRD4(1), DRD5(16), EDNRA(3), EDNRB(3), F2(6), F2R(3), F2RL1(7), F2RL2(3), FPR1(15), FSHB(2), FSHR(9), GABBR1(4), GABBR2(8), GABRA1(7), GABRA2(8), GABRA3(12), GABRA4(6), GABRA5(2), GABRA6(15), GABRB1(9), GABRB2(6), GABRB3(12), GABRD(4), GABRE(9), GABRG1(13), GABRG2(6), GABRG3(4), GABRP(8), GABRQ(3), GABRR1(4), GALR1(3), GH1(1), GH2(7), GHR(14), GHRHR(4), GHSR(5), GIPR(2), GLP1R(5), GLP2R(5), GLRA1(7), GLRA2(4), GLRA3(6), GLRB(11), GNRHR(2), GPR156(4), GPR35(2), GPR50(8), GPR63(4), GPR83(6), GRIA1(28), GRIA2(19), GRIA3(15), GRIA4(13), GRID1(12), GRID2(31), GRIK1(10), GRIK2(13), GRIK3(16), GRIK4(6), GRIK5(8), GRIN1(6), GRIN2A(48), GRIN2B(28), GRIN2C(6), GRIN2D(3), GRIN3A(23), GRIN3B(2), GRM1(7), GRM2(1), GRM3(30), GRM4(13), GRM5(5), GRM6(14), GRM7(18), GRM8(26), GRPR(2), GZMA(6), HCRTR2(15), HRH1(9), HRH2(3), HRH3(3), HRH4(4), HTR1A(6), HTR1D(2), HTR1E(3), HTR1F(5), HTR2A(6), HTR2C(5), HTR4(4), HTR5A(10), HTR6(1), HTR7(4), LEP(1), LEPR(10), LHCGR(10), MAS1(1), MC2R(2), MC3R(6), MC4R(1), MC5R(4), MCHR1(2), MCHR2(6), MLNR(1), MTNR1A(6), MTNR1B(5), NMBR(2), NMUR1(2), NMUR2(9), NPBWR1(1), NPBWR2(6), NPFFR2(6), NPY1R(10), NPY2R(8), NPY5R(11), NR3C1(1), NTSR1(3), NTSR2(1), OPRK1(14), OPRL1(3), OPRM1(4), OXTR(3), P2RX1(2), P2RX2(1), P2RX3(3), P2RX4(1), P2RX5(4), P2RX7(3), P2RY1(1), P2RY10(6), P2RY13(2), P2RY14(5), P2RY2(3), P2RY6(1), P2RY8(3), PARD3(9), PPYR1(9), PRL(1), PRLHR(1), PRLR(17), PRSS1(10), PRSS3(2), PTGDR(7), PTGER2(4), PTGER3(1), PTGFR(12), PTGIR(3), PTH2R(8), RXFP1(10), RXFP2(9), SCTR(3), SSTR1(5), SSTR2(1), SSTR3(9), SSTR4(1), SSTR5(2), TAAR1(2), TAAR2(8), TAAR5(1), TAAR6(3), TAAR8(3), TAAR9(1), TACR1(3), TACR2(3), TACR3(16), TBXA2R(3), THRA(1), THRB(10), TRHR(9), TRPV1(1), TSHB(2), TSHR(6), UTS2R(1), VIPR1(3), VIPR2(3) 33655818 1341 97 1298 861 997 103 37 99 105 0 1.95e-05 1.000 1.000 142 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(12), ACACB(12), AKT1(1), AKT2(6), AKT3(2), BRAF(64), CALM2(1), CALML3(3), CBL(4), CBLB(7), CBLC(12), CRK(2), EXOC7(5), FASN(9), FBP1(1), FLOT1(1), FOXO1(4), G6PC(4), G6PC2(2), GCK(8), GRB2(2), GSK3B(1), GYS1(2), GYS2(10), IKBKB(2), INPP5D(19), INSR(11), IRS1(2), IRS4(5), KRAS(1), LIPE(5), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK10(5), MAPK3(1), MAPK9(1), MKNK1(5), MKNK2(2), NRAS(29), PCK1(15), PCK2(2), PDE3A(13), PDE3B(3), PDPK1(1), PFKL(2), PHKA1(8), PHKA2(5), PHKB(3), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PKLR(6), PKM2(4), PPARGC1A(14), PPP1CA(1), PPP1CB(3), PPP1CC(1), PPP1R3A(29), PPP1R3B(2), PPP1R3C(2), PPP1R3D(1), PRKAA1(1), PRKAA2(15), PRKAB2(1), PRKACA(2), PRKACB(2), PRKACG(5), PRKAG1(1), PRKAG2(2), PRKAG3(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKCI(4), PRKCZ(1), PRKX(1), PTPN1(1), PTPRF(15), PYGB(2), PYGL(2), PYGM(6), RAF1(2), RAPGEF1(3), RPS6(1), RPS6KB1(1), RPS6KB2(2), SH2B2(3), SHC2(4), SHC3(7), SLC2A4(2), SOCS3(2), SOCS4(2), SORBS1(6), SOS1(4), SOS2(3), SREBF1(2), TRIP10(2), TSC1(3), TSC2(6) 24499465 548 97 464 234 349 33 26 108 32 0 0.00170 1.000 1.000 143 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(16), ADCY2(6), ADCY3(2), ADCY4(1), ADCY7(6), ADCY8(26), ADCY9(9), ADORA2A(1), ADORA2B(1), ADRA1A(4), ADRA1B(1), ADRA1D(3), ADRB1(3), ADRB2(1), AGTR1(6), ATP2A1(2), ATP2A2(3), ATP2A3(6), ATP2B1(3), ATP2B2(9), ATP2B3(5), ATP2B4(7), AVPR1A(2), AVPR1B(5), BDKRB1(4), BDKRB2(2), CACNA1A(19), CACNA1B(18), CACNA1C(27), CACNA1D(17), CACNA1E(62), CACNA1F(13), CACNA1G(19), CACNA1H(14), CACNA1I(20), CACNA1S(26), CALM2(1), CALML3(3), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CAMK4(8), CCKAR(8), CCKBR(8), CD38(3), CHP(1), CHRM1(4), CHRM2(7), CHRM3(10), CHRM5(1), CHRNA7(2), CYSLTR1(3), CYSLTR2(2), DRD1(7), EDNRA(3), EDNRB(3), EGFR(13), ERBB2(2), ERBB3(2), ERBB4(26), F2R(3), GNA11(2), GNA14(3), GNA15(2), GNAL(2), GNAQ(1), GNAS(12), GRIN1(6), GRIN2A(48), GRIN2C(6), GRIN2D(3), GRM1(7), GRM5(5), GRPR(2), HRH1(9), HRH2(3), HTR2A(6), HTR2C(5), HTR4(4), HTR5A(10), HTR6(1), HTR7(4), ITPKB(4), ITPR1(16), ITPR2(10), ITPR3(4), LHCGR(10), MYLK(17), MYLK2(4), NOS1(32), NOS3(11), NTSR1(3), OXTR(3), P2RX1(2), P2RX2(1), P2RX3(3), P2RX4(1), P2RX5(4), P2RX7(3), PDE1A(21), PDE1B(6), PDE1C(23), PDGFRA(13), PDGFRB(7), PHKA1(8), PHKA2(5), PHKB(3), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), PLCD1(2), PLCD3(1), PLCD4(1), PLCE1(22), PLCG1(4), PLCG2(9), PLCZ1(8), PPP3CA(4), PPP3CB(1), PPP3R2(5), PRKACA(2), PRKACB(2), PRKACG(5), PRKCA(5), PRKCG(9), PRKX(1), PTGER3(1), PTGFR(12), PTK2B(7), RYR1(52), RYR2(42), RYR3(42), SLC25A6(2), SLC8A1(13), SLC8A2(3), SLC8A3(16), SPHK1(1), SPHK2(5), TACR1(3), TACR2(3), TACR3(16), TBXA2R(3), TNNC2(2), TRHR(9), TRPC1(3), VDAC1(1), VDAC2(1), VDAC3(1) 40735960 1241 95 1202 852 917 85 42 93 101 3 0.199 1.000 1.000 144 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(6), CD36(3), CD44(4), CD47(1), CHAD(3), COL11A1(34), COL11A2(25), COL1A1(25), COL1A2(24), COL2A1(17), COL3A1(34), COL4A1(29), COL4A2(20), COL4A4(50), COL4A6(21), COL5A1(34), COL5A2(22), COL5A3(40), COL6A1(7), COL6A2(6), COL6A3(32), COL6A6(29), DAG1(3), FN1(8), FNDC1(23), FNDC3A(7), FNDC4(5), FNDC5(1), GP5(2), GP6(4), GP9(4), HMMR(4), HSPG2(15), IBSP(4), ITGA1(14), ITGA10(2), ITGA11(12), ITGA2(7), ITGA2B(6), ITGA3(4), ITGA4(18), ITGA5(11), ITGA6(5), ITGA7(15), ITGA8(22), ITGA9(9), ITGAV(4), ITGB1(3), ITGB3(7), ITGB4(11), ITGB6(8), ITGB7(3), ITGB8(9), LAMA1(21), LAMA2(24), LAMA3(31), LAMA4(4), LAMA5(17), LAMB1(6), LAMB2(5), LAMB3(17), LAMB4(20), LAMC1(8), LAMC2(10), LAMC3(6), RELN(42), SDC1(1), SDC2(1), SDC3(3), SDC4(2), SPP1(3), SV2A(13), SV2B(20), SV2C(6), THBS1(15), THBS2(5), THBS3(7), THBS4(7), TNC(16), TNN(27), TNR(44), TNXB(65), VTN(5), VWF(28) 34392960 1195 95 1170 540 937 68 39 78 72 1 0.0449 1.000 1.000 145 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(3), ACTG1(3), CHAD(3), COL11A1(34), COL11A2(25), COL17A1(14), COL1A1(25), COL1A2(24), COL2A1(17), COL3A1(34), COL4A1(29), COL4A2(20), COL4A4(50), COL4A6(21), COL5A1(34), COL5A2(22), COL5A3(40), COL6A1(7), COL6A2(6), COL6A3(32), COL6A6(29), COMP(4), DES(4), DSC1(23), DSC2(26), DSC3(19), DSG1(32), DSG2(15), DSG3(29), DSG4(33), FN1(8), GJA1(4), GJA10(9), GJA3(1), GJA4(3), GJA5(4), GJA8(10), GJA9(3), GJB2(3), GJB3(1), GJB4(5), GJB5(2), GJB6(4), GJB7(1), GJC1(4), GJC3(1), IBSP(4), INA(3), ITGA6(5), ITGB4(11), KRT1(11), KRT10(7), KRT12(8), KRT13(5), KRT14(1), KRT15(2), KRT16(4), KRT17(7), KRT18(2), KRT2(9), KRT20(4), KRT23(3), KRT24(4), KRT25(7), KRT27(2), KRT28(4), KRT3(6), KRT31(2), KRT32(8), KRT33A(2), KRT33B(2), KRT34(7), KRT35(6), KRT36(11), KRT37(4), KRT38(4), KRT39(8), KRT4(7), KRT40(3), KRT5(8), KRT6A(9), KRT6B(1), KRT6C(6), KRT7(3), KRT71(8), KRT72(4), KRT73(6), KRT74(6), KRT75(10), KRT76(8), KRT77(10), KRT78(12), KRT79(6), KRT8(1), KRT81(3), KRT82(5), KRT83(7), KRT84(3), KRT85(1), KRT86(6), KRT9(9), LAMA1(21), LAMA2(24), LAMA3(31), LAMA4(4), LAMA5(17), LAMB1(6), LAMB2(5), LAMB3(17), LAMB4(20), LAMC1(8), LAMC2(10), LAMC3(6), LMNA(3), LMNB2(4), NES(13), RELN(42), SPP1(3), THBS1(15), THBS2(5), THBS3(7), THBS4(7), TNC(16), TNN(27), TNR(44), TNXB(65), VIM(3), VTN(5), VWF(28) 38366653 1481 94 1443 658 1168 104 29 88 91 1 1.40e-05 1.000 1.000 146 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(1), ACVR1B(3), ACVR2A(1), ACVR2B(1), AMHR2(7), BMP2(3), BMP7(2), BMPR1A(1), BMPR1B(2), BMPR2(3), CCL14(2), CCL15(2), CCL16(1), CCL21(1), CCL24(1), CCL25(1), CCL28(1), CCL7(3), CCL8(2), CCR1(5), CCR2(6), CCR3(7), CCR4(4), CCR5(4), CCR6(1), CCR7(2), CCR8(2), CCR9(2), CD27(2), CD40(1), CD40LG(1), CLCF1(1), CNTFR(3), CSF1(7), CSF1R(6), CSF2(2), CSF2RA(8), CSF2RB(8), CSF3(1), CSF3R(5), CX3CL1(2), CX3CR1(9), CXCL10(2), CXCL11(1), CXCL12(1), CXCL14(1), CXCL3(1), CXCL5(2), CXCL9(2), CXCR3(2), CXCR6(4), EDA2R(3), EDAR(3), EGF(14), EGFR(13), EPO(4), EPOR(1), FAS(3), FASLG(10), FLT1(17), FLT3(18), FLT3LG(1), FLT4(16), GDF5(8), GH1(1), GH2(7), GHR(14), HGF(8), IFNA10(1), IFNA14(4), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(6), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR2(3), IFNB1(4), IFNG(2), IFNGR1(3), IFNGR2(2), IFNK(1), IFNW1(4), IL10(1), IL10RA(4), IL10RB(2), IL11(2), IL11RA(1), IL12A(2), IL12B(3), IL12RB1(8), IL12RB2(3), IL13(2), IL13RA1(2), IL15(1), IL15RA(3), IL17A(6), IL17RA(3), IL18(2), IL18R1(13), IL18RAP(13), IL19(2), IL1A(2), IL1B(2), IL1R1(6), IL1R2(5), IL1RAP(2), IL2(4), IL20(2), IL20RA(7), IL21(2), IL21R(10), IL22(1), IL22RA1(5), IL22RA2(1), IL23A(1), IL23R(1), IL25(1), IL26(2), IL28A(1), IL28B(2), IL28RA(4), IL29(1), IL2RA(4), IL2RB(6), IL2RG(2), IL3(2), IL3RA(4), IL4(1), IL4R(5), IL5(4), IL5RA(7), IL6R(2), IL6ST(4), IL7(3), IL7R(15), IL8(1), IL9R(4), INHBA(10), INHBB(4), INHBC(6), INHBE(1), KDR(22), KIT(7), KITLG(6), LEP(1), LEPR(10), LIF(1), LIFR(13), LTA(2), LTB(1), MET(7), MPL(1), NGFR(6), OSM(2), OSMR(26), PDGFB(1), PDGFC(12), PDGFRA(13), PDGFRB(7), PLEKHO2(5), PPBP(3), PRL(1), PRLR(17), RELT(1), TGFB2(1), TGFB3(1), TGFBR2(5), TNF(1), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10C(3), TNFRSF10D(4), TNFRSF11A(3), TNFRSF11B(8), TNFRSF13B(6), TNFRSF14(2), TNFRSF17(3), TNFRSF18(3), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(6), TNFRSF25(3), TNFRSF4(4), TNFRSF6B(1), TNFRSF8(9), TNFRSF9(2), TNFSF10(5), TNFSF11(3), TNFSF14(6), TNFSF15(6), TNFSF18(3), TNFSF4(3), TNFSF8(2), TNFSF9(1), TPO(28), TSLP(1), VEGFA(1), VEGFB(1), VEGFC(13), XCL1(1), XCL2(1), XCR1(1) 27102537 862 94 840 483 656 58 15 50 83 0 0.0554 1.000 1.000 147 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(64), CPEB1(5), EGFR(13), ERBB2(2), ERBB4(26), ETS1(3), ETS2(7), ETV6(8), ETV7(2), FMN2(40), GRB2(2), KRAS(1), MAP2K1(3), MAPK1(2), MAPK3(1), NOTCH1(3), NOTCH2(22), NOTCH3(14), NOTCH4(35), PIWIL1(14), PIWIL2(7), PIWIL3(10), PIWIL4(2), RAF1(2), SOS1(4), SOS2(3), SPIRE2(2) 8058591 297 94 242 103 175 17 7 85 13 0 0.0124 1.000 1.000 148 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(1), AKT2(6), AKT3(2), CBL(4), CBLB(7), CBLC(12), CCND2(3), CISH(1), CLCF1(1), CNTFR(3), CREBBP(12), CSF2(2), CSF2RA(8), CSF2RB(8), CSF3(1), CSF3R(5), EP300(7), EPO(4), EPOR(1), GH1(1), GH2(7), GHR(14), GRB2(2), IFNA10(1), IFNA14(4), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(6), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR2(3), IFNB1(4), IFNG(2), IFNGR1(3), IFNGR2(2), IFNK(1), IFNW1(4), IL10(1), IL10RA(4), IL10RB(2), IL11(2), IL11RA(1), IL12A(2), IL12B(3), IL12RB1(8), IL12RB2(3), IL13(2), IL13RA1(2), IL13RA2(1), IL15(1), IL15RA(3), IL19(2), IL2(4), IL20(2), IL20RA(7), IL21(2), IL21R(10), IL22(1), IL22RA1(5), IL22RA2(1), IL23A(1), IL23R(1), IL26(2), IL28A(1), IL28B(2), IL28RA(4), IL29(1), IL2RA(4), IL2RB(6), IL2RG(2), IL3(2), IL3RA(4), IL4(1), IL4R(5), IL5(4), IL5RA(7), IL6R(2), IL6ST(4), IL7(3), IL7R(15), IL9R(4), IRF9(1), JAK1(4), JAK2(6), JAK3(5), LEP(1), LEPR(10), LIF(1), LIFR(13), MPL(1), MYC(2), OSM(2), OSMR(26), PIAS1(2), PIAS2(4), PIAS3(3), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PIM1(1), PRL(1), PRLR(17), PTPN11(3), PTPN6(1), SOCS3(2), SOCS4(2), SOCS5(3), SOCS7(3), SOS1(4), SOS2(3), SPRED1(3), SPRED2(1), SPRY1(6), SPRY2(3), SPRY3(6), SPRY4(1), STAM(2), STAT1(2), STAT2(5), STAT3(6), STAT4(12), STAT5A(2), STAT5B(2), STAT6(2), TPO(28), TSLP(1), TYK2(3) 22337778 543 91 532 269 393 41 16 47 46 0 0.101 1.000 1.000 149 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(3), ACTN1(2), ACTR2(2), AKT1(1), AKT2(6), AKT3(2), ANGPTL2(2), ARHGEF6(5), ARHGEF7(2), BCAR1(3), BRAF(64), CAV1(1), CDKN2A(16), CRK(2), CSE1L(4), DOCK1(11), EPHB2(15), FYN(4), GRB2(2), GRB7(5), GRLF1(3), ITGA1(14), ITGA10(2), ITGA11(12), ITGA2(7), ITGA3(4), ITGA4(18), ITGA5(11), ITGA6(5), ITGA7(15), ITGA8(22), ITGA9(9), MAP2K4(3), MAP2K7(2), MAP3K11(3), MAPK1(2), MAPK10(5), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1), MYLK(17), MYLK2(4), P4HB(2), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PAK7(27), PIK3CA(2), PIK3CB(10), PKLR(6), PLCG1(4), PLCG2(9), PTEN(11), PTK2(2), RAF1(2), RHO(2), ROCK1(2), ROCK2(4), SOS1(4), SOS2(3), TLN1(10), TLN2(10), WAS(4), ZYX(3) 18665182 453 91 391 188 274 26 18 97 38 0 0.00524 1.000 1.000 150 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(3), ACTA2(3), ACTN2(14), ACTN3(5), ACTN4(2), DES(4), DMD(14), MYBPC1(12), MYBPC2(5), MYBPC3(6), MYH3(12), MYH6(15), MYH7(27), MYH8(28), MYL1(8), MYL2(4), MYL3(2), MYL4(5), MYL9(1), MYOM1(12), NEB(65), TCAP(1), TNNC2(2), TNNI1(1), TNNI3(1), TNNT1(2), TNNT2(2), TNNT3(3), TPM2(2), TPM3(2), TPM4(1), TTN(589), VIM(3) 20216259 856 90 819 354 650 61 29 67 41 8 3.67e-06 1.000 1.000 151 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(3), ABLIM1(7), ABLIM2(2), ABLIM3(4), ARHGEF12(6), CDK5(3), CHP(1), CXCL12(1), DCC(40), DPYSL2(4), DPYSL5(8), EFNA4(1), EFNA5(2), EFNB1(1), EFNB3(1), EPHA1(5), EPHA2(7), EPHA3(10), EPHA4(9), EPHA5(5), EPHA6(34), EPHA7(23), EPHA8(8), EPHB1(13), EPHB2(15), EPHB3(8), EPHB4(2), EPHB6(9), FES(4), FYN(4), GNAI2(2), GSK3B(1), ITGB1(3), KRAS(1), L1CAM(3), LIMK1(4), LIMK2(5), LRRC4C(19), MAPK1(2), MAPK3(1), MET(7), NCK2(3), NFAT5(3), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), NGEF(7), NRAS(29), NRP1(11), NTN4(10), NTNG1(6), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PAK7(27), PLXNA1(5), PLXNA2(6), PLXNA3(4), PLXNB1(12), PLXNB2(8), PLXNB3(2), PLXNC1(9), PPP3CA(4), PPP3CB(1), PPP3R2(5), PTK2(2), RAC1(7), RASA1(1), RGS3(8), RHOD(1), RND1(3), ROBO1(12), ROBO2(17), ROBO3(8), ROCK1(2), ROCK2(4), SEMA3A(8), SEMA3B(2), SEMA3C(2), SEMA3D(6), SEMA3E(11), SEMA3F(5), SEMA3G(8), SEMA4A(5), SEMA4B(3), SEMA4C(4), SEMA4D(5), SEMA4F(5), SEMA4G(4), SEMA5A(10), SEMA5B(9), SEMA6A(5), SEMA6B(5), SEMA6C(5), SEMA6D(2), SEMA7A(1), SLIT1(9), SLIT2(32), SLIT3(25), SRGAP2(2), SRGAP3(17), UNC5A(5), UNC5B(6), UNC5C(9), UNC5D(13) 29831996 763 89 722 407 554 54 24 78 51 2 0.0575 1.000 1.000 152 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(16), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(9), ADCY6(5), ADCY7(6), ADCY8(26), ADCY9(9), ADRA1A(4), ADRA1B(1), ADRA1D(3), ADRB1(3), ADRB2(1), ANXA6(3), ARRB1(1), ARRB2(3), ATP1A4(8), ATP1B1(1), ATP2A2(3), ATP2A3(6), ATP2B1(3), ATP2B2(9), ATP2B3(5), CACNA1A(19), CACNA1B(18), CACNA1C(27), CACNA1D(17), CACNA1E(62), CACNA1S(26), CACNB1(1), CACNB3(2), CALM2(1), CAMK1(4), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CAMK4(8), CASQ1(5), CASQ2(2), CHRM1(4), CHRM2(7), CHRM3(10), CHRM4(4), CHRM5(1), GJA1(4), GJA4(3), GJA5(4), GJB2(3), GJB3(1), GJB4(5), GJB5(2), GJB6(4), GNA11(2), GNAI2(2), GNAO1(1), GNAQ(1), GNAZ(3), GNB3(5), GNB4(1), GNB5(2), GNG2(2), GNG4(2), GNG7(2), GRK4(6), GRK5(3), GRK6(1), ITPR1(16), ITPR2(10), ITPR3(4), KCNB1(13), KCNJ3(11), KCNJ5(6), MIB1(4), NME7(4), PKIA(1), PKIG(1), PLCB3(2), PRKACA(2), PRKACB(2), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCH(2), PRKCQ(12), PRKCZ(1), PRKD1(1), RGS1(3), RGS11(1), RGS14(3), RGS18(4), RGS20(1), RGS3(8), RGS4(2), RGS5(2), RGS6(9), RGS7(22), RGS9(7), RYR1(52), RYR2(42), RYR3(42), SFN(1), SLC8A1(13), SLC8A3(16), USP5(2), YWHAQ(1) 28483462 770 87 742 540 562 64 24 55 62 3 0.441 1.000 1.000 153 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(11), APC2(4), AXIN1(6), AXIN2(2), BTRC(3), CACYBP(1), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CCND2(3), CER1(6), CHD8(11), CHP(1), CREBBP(12), CSNK1A1(1), CSNK1A1L(3), CSNK1E(3), CSNK2B(1), CTNNB1(5), CTNNBIP1(1), CUL1(2), DAAM1(3), DKK1(1), DKK2(7), DKK4(1), DVL2(2), DVL3(4), EP300(7), FBXW11(4), FZD1(1), FZD10(1), FZD2(2), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(3), GSK3B(1), JUN(1), LEF1(1), LRP5(9), LRP6(9), MAPK10(5), MAPK9(1), MMP7(2), MYC(2), NFAT5(3), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), NKD1(5), NKD2(4), NLK(2), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), PORCN(2), PPARD(1), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(2), PPP2R2C(4), PPP3CA(4), PPP3CB(1), PPP3R2(5), PRICKLE1(5), PRICKLE2(2), PRKACA(2), PRKACB(2), PRKACG(5), PRKCA(5), PRKCG(9), PRKX(1), RAC1(7), ROCK1(2), ROCK2(4), SENP2(8), SFRP2(7), SFRP4(3), SMAD2(1), SOX17(2), TBL1X(1), TBL1XR1(1), TBL1Y(3), TCF7L1(1), TCF7L2(3), TP53(20), VANGL1(1), VANGL2(6), WIF1(4), WNT1(1), WNT10A(4), WNT10B(3), WNT11(2), WNT16(1), WNT2(5), WNT2B(1), WNT3(3), WNT3A(5), WNT4(2), WNT5A(4), WNT5B(2), WNT6(2), WNT7A(9), WNT7B(2), WNT8A(4), WNT8B(4), WNT9A(1), WNT9B(3) 24617699 452 87 437 219 299 36 17 58 42 0 0.112 1.000 1.000 154 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(1), AKT2(6), AKT3(2), BRAF(64), DAG1(3), DRD2(8), EGFR(13), EPHB2(15), GRB2(2), ITPKB(4), ITPR1(16), ITPR2(10), ITPR3(4), KCNJ3(11), KCNJ5(6), KCNJ9(2), MAPK1(2), PI3(5), PIK3CB(10), PITX2(1), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), RAF1(2), RGS20(1), SOS1(4), SOS2(3), STAT3(6) 8973715 268 87 210 119 150 21 12 70 15 0 0.0633 1.000 1.000 155 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(1), ADORA2A(1), ADORA2B(1), ADORA3(10), ADRA1A(4), ADRA1B(1), ADRA1D(3), ADRA2A(2), ADRA2C(2), ADRB1(3), ADRB2(1), AGTR1(6), AGTR2(2), AVPR1A(2), AVPR1B(5), BDKRB1(4), BDKRB2(2), BRS3(2), C3AR1(2), CCBP2(5), CCKAR(8), CCKBR(8), CCR1(5), CCR10(1), CCR2(6), CCR3(7), CCR4(4), CCR5(4), CCR6(1), CCR7(2), CCR8(2), CCR9(2), CCRL2(1), CHML(1), CHRM1(4), CHRM2(7), CHRM3(10), CHRM4(4), CHRM5(1), CMKLR1(7), CNR1(7), CNR2(1), CX3CR1(9), CXCR3(2), DRD1(7), DRD2(8), DRD3(1), DRD4(1), DRD5(16), EDNRA(3), EDNRB(3), F2R(3), F2RL1(7), F2RL2(3), FPR1(15), FSHR(9), GALR1(3), GALT(2), GHSR(5), GNB2L1(1), GPR173(1), GPR174(5), GPR27(2), GPR3(2), GPR35(2), GPR37(4), GPR37L1(3), GPR4(3), GPR50(8), GPR6(4), GPR63(4), GPR77(3), GPR83(6), GPR85(3), GPR87(3), GRPR(2), HCRTR2(15), HRH1(9), HRH2(3), HRH3(3), HTR1A(6), HTR1D(2), HTR1E(3), HTR1F(5), HTR2A(6), HTR2C(5), HTR4(4), HTR5A(10), HTR6(1), HTR7(4), LHCGR(10), MAS1(1), MC3R(6), MC4R(1), MC5R(4), MLNR(1), MTNR1A(6), MTNR1B(5), NMBR(2), NMUR1(2), NMUR2(9), NPY1R(10), NPY2R(8), NPY5R(11), NTSR1(3), NTSR2(1), OPN1SW(1), OPN3(1), OPRK1(14), OPRL1(3), OPRM1(4), OR10A5(3), OR11A1(2), OR12D3(4), OR1C1(5), OR1F1(2), OR1Q1(4), OR2H1(4), OR5V1(7), OR7C1(1), OR8B8(7), OXTR(3), P2RY1(1), P2RY10(6), P2RY12(1), P2RY13(2), P2RY14(5), P2RY2(3), P2RY6(1), PPYR1(9), PTGDR(7), PTGER2(4), PTGFR(12), PTGIR(3), RGR(3), RHO(2), SSTR1(5), SSTR2(1), SSTR3(9), SSTR4(1), SUCNR1(7), TBXA2R(3), TRHR(9) 18558718 620 86 604 494 432 62 22 57 47 0 0.0553 1.000 1.000 156 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(3), ACTG1(3), ACTN1(2), ACTN2(14), ACTN3(5), ACTN4(2), AKT1(1), AKT2(6), AKT3(2), AMOTL1(2), ASH1L(18), CASK(2), CDK4(2), CGN(5), CLDN1(5), CLDN10(3), CLDN11(3), CLDN14(4), CLDN16(4), CLDN17(3), CLDN18(3), CLDN19(2), CLDN2(2), CLDN20(1), CLDN22(1), CLDN4(5), CLDN6(4), CLDN7(1), CLDN8(2), CLDN9(1), CSDA(1), CSNK2B(1), CTNNA1(2), CTNNA2(14), CTNNA3(13), CTNNB1(5), CTTN(1), EPB41(4), EPB41L1(6), EPB41L2(8), EPB41L3(5), EXOC3(2), EXOC4(4), F11R(4), GNAI2(2), HCLS1(7), IGSF5(5), INADL(24), JAM2(6), JAM3(1), KRAS(1), LLGL1(1), LLGL2(6), MAGI1(16), MAGI2(14), MAGI3(8), MLLT4(8), MPDZ(7), MYH1(46), MYH10(5), MYH11(20), MYH13(18), MYH14(10), MYH15(30), MYH2(38), MYH3(12), MYH4(44), MYH6(15), MYH7(27), MYH7B(18), MYH8(28), MYH9(6), MYL2(4), MYL9(1), MYLPF(1), NRAS(29), OCLN(2), PARD3(9), PARD6G(2), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(2), PPP2R2C(4), PPP2R3A(2), PPP2R3B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCH(2), PRKCI(4), PRKCQ(12), PRKCZ(1), PTEN(11), RRAS(1), SPTAN1(2), SYMPK(2), TJAP1(2), TJP1(5), TJP2(3), TJP3(9), YES1(3), ZAK(4) 29640978 751 86 709 498 515 61 31 76 65 3 0.884 1.000 1.000 157 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(16), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(9), ADCY6(5), ADCY7(6), ADCY8(26), ADCY9(9), CALM2(1), CALML3(3), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CREB3L1(2), CREB3L2(5), CREB3L3(5), CREB3L4(1), CREBBP(12), CTNNB1(5), DCT(1), DVL2(2), DVL3(4), EDN1(6), EDNRB(3), EP300(7), FZD1(1), FZD10(1), FZD2(2), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(3), GNAI2(2), GNAO1(1), GNAQ(1), GNAS(12), GSK3B(1), KIT(7), KITLG(6), KRAS(1), LEF1(1), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK3(1), MITF(1), NRAS(29), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), POMC(3), PRKACA(2), PRKACB(2), PRKACG(5), PRKCA(5), PRKCG(9), PRKX(1), RAF1(2), TCF7L1(1), TCF7L2(3), TYR(2), TYRP1(3), WNT1(1), WNT10A(4), WNT10B(3), WNT11(2), WNT16(1), WNT2(5), WNT2B(1), WNT3(3), WNT3A(5), WNT4(2), WNT5A(4), WNT5B(2), WNT6(2), WNT7A(9), WNT7B(2), WNT8A(4), WNT8B(4), WNT9A(1), WNT9B(3) 16536692 394 86 357 207 265 24 19 53 33 0 0.0515 1.000 1.000 158 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(3), ACTA2(3), ADCY1(16), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(9), ADCY6(5), ADCY7(6), ADCY8(26), ADCY9(9), ARRB1(1), ARRB2(3), ATF1(2), ATF2(5), ATF4(4), ATF5(2), ATP2A2(3), ATP2A3(6), CACNB3(2), CALM2(1), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CNN1(1), CNN2(2), CORIN(12), CRH(2), CRHR1(1), DGKZ(6), ETS2(7), FOS(1), GABPB2(4), GBA2(2), GJA1(4), GNAQ(1), GNB3(5), GNB4(1), GNB5(2), GNG2(2), GNG4(2), GNG7(2), GRK4(6), GRK5(3), GRK6(1), GSTO1(2), GUCY1A3(18), IGFBP1(1), IGFBP2(1), IGFBP3(1), IGFBP6(2), IL1B(2), ITPR1(16), ITPR2(10), ITPR3(4), JUN(1), MIB1(4), MYL2(4), MYL4(5), MYLK2(4), NFKB1(1), NOS1(32), NOS3(11), OXTR(3), PDE4B(4), PDE4D(3), PKIA(1), PKIG(1), PLCB3(2), PLCD1(2), PLCG1(4), PLCG2(9), PRKACA(2), PRKACB(2), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCH(2), PRKCQ(12), PRKCZ(1), PRKD1(1), RAMP1(1), RAMP3(1), RGS1(3), RGS11(1), RGS14(3), RGS18(4), RGS20(1), RGS3(8), RGS4(2), RGS5(2), RGS6(9), RGS7(22), RGS9(7), RLN1(3), RYR1(52), RYR2(42), RYR3(42), SFN(1), SLC8A1(13), SP1(3), TNXB(65), USP5(2), YWHAQ(1) 26645913 665 86 645 400 494 51 18 48 51 3 0.0641 1.000 1.000 159 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(5), BRAF(64), CHUK(1), DAXX(4), FOS(1), GRB2(2), IKBKB(2), JUN(1), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAP2K5(2), MAP2K6(2), MAP2K7(2), MAP3K10(5), MAP3K11(3), MAP3K12(2), MAP3K13(5), MAP3K14(1), MAP3K2(2), MAP3K3(3), MAP3K4(9), MAP3K5(9), MAP3K6(5), MAP3K9(13), MAP4K1(3), MAP4K2(4), MAP4K3(4), MAP4K4(5), MAP4K5(2), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(2), MAPK14(4), MAPK3(1), MAPK4(8), MAPK6(2), MAPK7(2), MAPK9(1), MAPKAPK2(2), MAPKAPK3(1), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), MKNK1(5), MKNK2(2), MYC(2), NFKB1(1), NFKBIA(1), PAK1(2), PAK2(2), RAC1(7), RAF1(2), RELA(1), RIPK1(1), RPS6KA1(2), RPS6KA2(4), RPS6KA4(2), RPS6KA5(3), RPS6KB1(1), RPS6KB2(2), SP1(3), STAT1(2), TGFB2(1), TGFB3(1), TRAF2(1) 14478089 260 85 206 109 147 26 10 64 13 0 0.126 1.000 1.000 160 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(16), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(9), ADCY6(5), ADCY7(6), ADCY8(26), ADCY9(9), ATF4(4), CACNA1C(27), CACNA1D(17), CACNA1F(13), CACNA1S(26), CALM2(1), CALML3(3), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), EGFR(13), FSHB(2), GNA11(2), GNAQ(1), GNAS(12), GNRH2(2), GNRHR(2), GRB2(2), ITPR1(16), ITPR2(10), ITPR3(4), JUN(1), KRAS(1), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP2K7(2), MAP3K2(2), MAP3K3(3), MAP3K4(9), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(2), MAPK14(4), MAPK3(1), MAPK7(2), MAPK9(1), MMP2(3), NRAS(29), PLA2G12B(3), PLA2G2A(1), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(12), PLA2G4A(7), PLA2G6(7), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), PLD1(5), PLD2(2), PRKACA(2), PRKACB(2), PRKACG(5), PRKCA(5), PRKCD(2), PRKX(1), PTK2B(7), RAF1(2), SOS1(4), SOS2(3) 19285471 476 84 437 291 326 39 23 54 34 0 0.354 1.000 1.000 161 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(16), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(9), ADCY6(5), ADCY7(6), ADCY8(26), ADCY9(9), AKAP1(7), AKAP11(6), AKAP12(1), AKAP3(8), AKAP4(5), AKAP6(16), AKAP7(1), AKAP8(5), AKAP9(18), ARHGEF1(1), CALM2(1), CHMP1B(1), GNA11(2), GNA12(2), GNA13(1), GNA14(3), GNA15(2), GNAI2(2), GNAL(2), GNAO1(1), GNAQ(1), GNAZ(3), GNB3(5), GNB5(2), GNG4(2), GNG7(2), GNGT2(2), ITPR1(16), KCNJ3(11), KRAS(1), NRAS(29), PDE1A(21), PDE1B(6), PDE1C(23), PDE4A(2), PDE4B(4), PDE4C(7), PDE4D(3), PDE7B(10), PDE8A(2), PDE8B(10), PLCB3(2), PPP3CA(4), PRKACA(2), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCH(2), PRKCI(4), PRKCQ(12), PRKCZ(1), PRKD1(1), PRKD3(2), RRAS(1), SLC9A1(1), USP5(2) 17909276 393 83 364 216 267 28 18 50 30 0 0.198 1.000 1.000 162 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM2(1), CALML3(3), CDS1(5), CDS2(2), DGKA(1), DGKB(14), DGKD(3), DGKE(5), DGKG(8), DGKH(6), DGKI(12), DGKQ(2), DGKZ(6), IMPA1(1), IMPA2(1), INPP1(2), INPP4A(4), INPP5A(2), INPP5B(3), INPP5D(19), INPPL1(9), ITPK1(4), ITPKB(4), ITPR1(16), ITPR2(10), ITPR3(4), OCRL(2), PI4KA(7), PIK3C2A(3), PIK3C2B(7), PIK3C2G(20), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PIP4K2A(3), PIP4K2B(2), PIP4K2C(1), PIP5K1A(6), PIP5K1B(11), PIP5K1C(4), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), PLCD1(2), PLCD3(1), PLCD4(1), PLCE1(22), PLCG1(4), PLCG2(9), PLCZ1(8), PRKCA(5), PRKCG(9), PTEN(11), SYNJ1(8), SYNJ2(9) 18974252 405 83 392 208 289 24 19 35 38 0 0.0660 1.000 1.000 163 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(16), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(9), ADCY6(5), ADCY7(6), ADCY8(26), ADCY9(9), ADRB1(3), CSNK1D(1), DRD1(7), DRD2(8), EGF(14), EGFR(13), GJA1(4), GNA11(2), GNAI2(2), GNAQ(1), GNAS(12), GRB2(2), GRM1(7), GRM5(5), GUCY1A2(8), GUCY1A3(18), GUCY1B3(4), GUCY2C(16), GUCY2D(3), GUCY2F(7), HTR2A(6), HTR2C(5), ITPR1(16), ITPR2(10), ITPR3(4), KRAS(1), MAP2K1(3), MAP2K2(2), MAP2K5(2), MAP3K2(2), MAPK1(2), MAPK3(1), MAPK7(2), NPR1(12), NPR2(11), NRAS(29), PDGFA(1), PDGFB(1), PDGFC(12), PDGFD(2), PDGFRA(13), PDGFRB(7), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), PRKACA(2), PRKACB(2), PRKACG(5), PRKCA(5), PRKCG(9), PRKG1(5), PRKG2(8), PRKX(1), RAF1(2), SOS1(4), SOS2(3), TJP1(5), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(10), TUBA3D(5), TUBA3E(1), TUBA4A(3), TUBA8(1), TUBAL3(8), TUBB1(2), TUBB2A(1), TUBB3(3), TUBB4(1), TUBB4Q(4), TUBB6(5), TUBB8(6) 20143435 533 83 487 310 376 34 24 59 40 0 0.115 1.000 1.000 164 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(17), BDKRB1(4), BDKRB2(2), C1QA(3), C1QB(1), C1QC(4), C1R(8), C1S(11), C2(8), C3(21), C3AR1(2), C4BPA(9), C4BPB(3), C5(5), C5AR1(4), C6(36), C7(17), C8A(23), C8B(25), C9(11), CD55(2), CD59(1), CFB(21), CFH(23), CFI(7), CR1(29), CR2(16), F10(2), F11(8), F12(1), F13A1(16), F13B(13), F2(6), F2R(3), F5(19), F7(2), F8(21), F9(6), FGA(19), FGB(6), FGG(3), KLKB1(15), KNG1(3), MASP1(5), MASP2(7), MBL2(7), PLAT(2), PLAU(2), PLG(14), PROC(7), PROS1(8), SERPINA1(6), SERPINA5(5), SERPINC1(5), SERPIND1(2), SERPINE1(2), SERPINF2(3), SERPING1(7), TFPI(5), THBD(2), VWF(28) 13831525 573 83 549 262 428 40 17 46 40 2 0.0190 1.000 1.000 165 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(1), ATF1(2), BRAF(64), CREB5(7), CREBBP(12), DAG1(3), EGR1(1), EGR2(3), EGR3(1), EGR4(1), FRS2(1), GNAQ(1), JUN(1), MAP1B(12), MAP2K4(3), MAP2K7(2), MAPK1(2), MAPK10(5), MAPK3(1), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1), NTRK1(9), OPN1LW(3), PIK3C2G(20), PIK3CA(2), PIK3CD(2), PIK3R1(2), PTPN11(3), TH(6) 7840314 182 83 131 72 102 7 6 59 8 0 0.109 1.000 1.000 166 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(2), ADCY1(16), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(9), ADCY6(5), ADCY7(6), ADCY8(26), ADCY9(9), ADK(3), ADSL(6), ADSSL1(4), AK1(1), AK2(1), AK5(5), AK7(12), ALLC(3), AMPD1(19), AMPD2(2), AMPD3(14), ATIC(1), CANT1(4), DGUOK(4), ENPP1(7), ENPP3(8), ENTPD1(5), ENTPD2(3), ENTPD3(3), ENTPD4(2), ENTPD6(2), ENTPD8(1), FHIT(1), GART(5), GDA(5), GMPS(3), GUCY1A2(8), GUCY1A3(18), GUCY1B3(4), GUCY2C(16), GUCY2D(3), GUCY2F(7), IMPDH2(1), NME7(4), NPR1(12), NPR2(11), NT5C1B(16), NT5C3(2), NT5E(3), NT5M(1), NUDT5(1), NUDT9(1), PAPSS1(1), PAPSS2(2), PDE10A(6), PDE11A(12), PDE1A(21), PDE1C(23), PDE2A(7), PDE3B(3), PDE4A(2), PDE4B(4), PDE4C(7), PDE4D(3), PDE5A(4), PDE6D(2), PDE6G(2), PDE7B(10), PDE8A(2), PDE8B(10), PDE9A(4), PFAS(2), PKLR(6), PKM2(4), PNPT1(1), POLA1(1), POLA2(6), POLD1(2), POLD2(1), POLD3(3), POLE(9), POLE2(1), POLR1A(7), POLR1B(4), POLR1C(1), POLR2A(8), POLR2B(10), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2L(1), POLR3A(2), POLR3B(10), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(8), PRPS1(1), PRPS1L1(7), PRPS2(1), PRUNE(1), RRM1(2), RRM2B(1), XDH(33) 25072558 580 82 566 283 412 43 26 47 52 0 0.00191 1.000 1.000 167 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(1), AKT2(6), AKT3(2), BRAF(64), CAB39(1), EIF4B(1), FIGF(4), IGF1(6), MAPK1(2), MAPK3(1), PDPK1(1), PGF(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PRKAA1(1), PRKAA2(15), RICTOR(5), RPS6(1), RPS6KA1(2), RPS6KA2(4), RPS6KA6(3), RPS6KB1(1), RPS6KB2(2), STK11(2), TSC1(3), TSC2(6), ULK1(4), ULK2(4), ULK3(1), VEGFA(1), VEGFB(1), VEGFC(13) 8074143 195 82 143 76 100 9 8 66 12 0 0.129 1.000 1.000 168 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(10), CD14(3), CD19(3), CD1A(5), CD1B(4), CD1C(12), CD1D(6), CD1E(9), CD2(13), CD22(15), CD33(9), CD36(3), CD37(1), CD38(3), CD3D(4), CD3E(2), CD4(3), CD44(4), CD5(3), CD55(2), CD59(1), CD8A(1), CD8B(4), CR1(29), CR2(16), CSF1(7), CSF1R(6), CSF2(2), CSF2RA(8), CSF3(1), CSF3R(5), DNTT(7), EPO(4), EPOR(1), FCER2(1), FCGR1A(3), FLT3(18), FLT3LG(1), GP5(2), GP9(4), GYPA(3), HLA-DRA(5), IL11(2), IL11RA(1), IL1A(2), IL1B(2), IL1R1(6), IL1R2(5), IL2RA(4), IL3(2), IL3RA(4), IL4(1), IL4R(5), IL5(4), IL5RA(7), IL6R(2), IL7(3), IL7R(15), IL9R(4), ITGA1(14), ITGA2(7), ITGA2B(6), ITGA3(4), ITGA4(18), ITGA5(11), ITGA6(5), ITGAM(14), ITGB3(7), KIT(7), KITLG(6), MME(11), MS4A1(4), TFRC(3), THPO(3), TNF(1), TPO(28) 12460405 461 82 440 236 350 26 13 28 44 0 0.0814 1.000 1.000 169 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(1), AKT2(6), AKT3(2), BCL10(1), CARD11(18), CBL(4), CBLB(7), CBLC(12), CD247(1), CD3D(4), CD3E(2), CD4(3), CD40LG(1), CD8A(1), CD8B(4), CDK4(2), CHP(1), CHUK(1), CSF2(2), CTLA4(1), FOS(1), FYN(4), GRAP2(1), GRB2(2), ICOS(2), IFNG(2), IKBKB(2), IL10(1), IL2(4), IL4(1), IL5(4), ITK(15), JUN(1), KRAS(1), LCK(4), LCP2(5), MALT1(2), MAP3K14(1), NCK2(3), NFAT5(3), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(1), NRAS(29), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PAK7(27), PDCD1(3), PDK1(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PLCG1(4), PPP3CA(4), PPP3CB(1), PPP3R2(5), PRKCQ(12), PTPN6(1), PTPRC(18), RASGRP1(6), SOS1(4), SOS2(3), TEC(6), TNF(1), VAV1(12), VAV2(3), VAV3(5), ZAP70(4) 15556662 359 82 322 175 236 23 20 59 21 0 0.285 1.000 1.000 170 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(11), AMY2A(3), AMY2B(5), ASCC3(4), ATP13A2(6), DDX18(1), DDX23(4), DDX4(7), DDX41(3), DDX47(1), DDX50(2), DDX51(3), DDX52(3), DDX55(2), DDX56(2), DHX58(3), ENPP1(7), ENPP3(8), ENTPD7(1), EP400(13), ERCC2(1), ERCC3(2), G6PC(4), G6PC2(2), GAA(3), GANC(1), GBA(2), GBA3(5), GBE1(7), GCK(8), GPI(2), GUSB(2), GYS1(2), GYS2(10), HK1(1), HK2(4), HK3(10), IFIH1(4), MGAM(71), MOV10L1(16), NUDT5(1), NUDT8(1), PGM1(2), PGM3(1), PYGB(2), PYGL(2), PYGM(6), RAD54B(4), RUVBL2(1), SETX(12), SI(34), SKIV2L2(3), SMARCA2(8), SMARCA5(3), TREH(1), UGP2(1), UGT1A1(1), UGT1A10(10), UGT1A3(6), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(7), UGT1A8(2), UGT1A9(5), UGT2A1(8), UGT2A3(14), UGT2B10(17), UGT2B11(10), UGT2B15(16), UGT2B28(14), UGT2B4(18), UGT2B7(8), UXS1(1) 18811600 476 81 457 202 333 38 14 44 47 0 0.00141 1.000 1.000 171 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), AKR1C1(2), AKR1C2(2), AKR1C3(6), AKR1C4(4), ALDH1A3(2), ALDH3A1(3), ALDH3B1(1), ALDH3B2(4), CYP1A1(8), CYP1A2(8), CYP1B1(1), CYP2B6(9), CYP2C18(17), CYP2C19(25), CYP2C8(18), CYP2C9(24), CYP2E1(8), CYP2F1(6), CYP2S1(6), CYP3A4(12), CYP3A43(8), CYP3A5(4), CYP3A7(12), DHDH(4), EPHX1(1), GSTA1(5), GSTA3(1), GSTA5(1), GSTK1(1), GSTM1(1), GSTM3(1), GSTM4(1), GSTM5(2), MGST1(1), MGST2(1), UGT1A1(1), UGT1A10(10), UGT1A3(6), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(7), UGT1A8(2), UGT1A9(5), UGT2A1(8), UGT2A3(14), UGT2B10(17), UGT2B11(10), UGT2B15(16), UGT2B28(14), UGT2B4(18), UGT2B7(8) 8765053 421 81 401 182 316 28 19 27 31 0 1.30e-05 1.000 1.000 172 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 110 ABL1(3), ANAPC1(6), ANAPC2(1), ANAPC5(3), ANAPC7(4), ATM(8), ATR(13), BUB1B(5), CCNA1(7), CCNB2(1), CCNB3(16), CCND2(3), CCNE1(1), CCNE2(10), CCNH(1), CDC14A(2), CDC14B(1), CDC16(1), CDC25A(5), CDC25B(1), CDC25C(3), CDC27(5), CDC6(1), CDC7(2), CDK4(2), CDKN1A(1), CDKN2A(16), CHEK1(1), CREBBP(12), CUL1(2), DBF4(2), E2F1(5), E2F2(1), E2F3(2), EP300(7), ESPL1(10), FZR1(1), GADD45B(1), GSK3B(1), HDAC1(1), MAD1L1(2), MCM2(7), MCM3(5), MCM4(2), MCM5(2), MCM6(2), MDM2(2), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(1), ORC5L(1), ORC6L(2), PCNA(1), PKMYT1(1), PRKDC(11), PTTG1(1), PTTG2(3), RB1(3), RBL1(4), RBL2(2), SFN(1), SMAD2(1), SMC1A(2), SMC1B(8), TGFB2(1), TGFB3(1), TP53(20), YWHAG(1), YWHAQ(1) 21007224 260 81 247 98 149 17 16 36 40 2 0.0131 1.000 1.000 173 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(3), CADM1(1), CADM3(6), CD2(13), CD22(15), CD226(4), CD274(1), CD276(4), CD4(3), CD40(1), CD40LG(1), CD58(1), CD6(4), CD86(12), CD8A(1), CD8B(4), CD99(1), CDH1(4), CDH15(6), CDH2(9), CDH4(17), CDH5(4), CLDN1(5), CLDN10(3), CLDN11(3), CLDN14(4), CLDN16(4), CLDN17(3), CLDN18(3), CLDN19(2), CLDN2(2), CLDN20(1), CLDN22(1), CLDN4(5), CLDN6(4), CLDN7(1), CLDN8(2), CLDN9(1), CNTN1(10), CNTN2(4), CNTNAP1(7), CNTNAP2(44), CTLA4(1), ESAM(3), F11R(4), GLG1(1), HLA-A(1), HLA-B(4), HLA-C(1), HLA-DMA(2), HLA-DMB(3), HLA-DOA(3), HLA-DOB(1), HLA-DQA1(3), HLA-DQA2(2), HLA-DQB1(3), HLA-DRA(5), HLA-F(4), HLA-G(3), ICAM1(2), ICAM2(4), ICAM3(2), ICOS(2), ICOSLG(2), ITGA4(18), ITGA6(5), ITGA8(22), ITGA9(9), ITGAL(15), ITGAM(14), ITGAV(4), ITGB1(3), ITGB2(8), ITGB7(3), ITGB8(9), JAM2(6), JAM3(1), L1CAM(3), MADCAM1(1), MAG(10), MPZ(4), MPZL1(1), NCAM1(5), NCAM2(4), NEGR1(3), NEO1(6), NFASC(25), NLGN1(3), NLGN2(5), NLGN3(5), NRCAM(7), NRXN1(30), NRXN2(10), NRXN3(16), OCLN(2), PDCD1(3), PDCD1LG2(1), PTPRC(18), PTPRF(15), PTPRM(4), PVRL1(3), PVRL2(2), PVRL3(1), SDC1(1), SDC2(1), SDC3(3), SDC4(2), SELE(19), SELL(5), SELP(13), SELPLG(3), SIGLEC1(12), SPN(3), VCAM1(13), VCAN(19) 22383670 678 81 652 340 510 50 21 51 46 0 0.00477 1.000 1.000 174 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(2), ACTN2(14), ACTN3(5), ACTN4(2), ARHGAP5(7), BCAR1(3), CD99(1), CDH5(4), CLDN1(5), CLDN10(3), CLDN11(3), CLDN14(4), CLDN16(4), CLDN17(3), CLDN18(3), CLDN19(2), CLDN2(2), CLDN20(1), CLDN22(1), CLDN4(5), CLDN6(4), CLDN7(1), CLDN8(2), CLDN9(1), CTNNA1(2), CTNNA2(14), CTNNA3(13), CTNNB1(5), CTNND1(7), CXCL12(1), CYBA(1), CYBB(3), ESAM(3), EZR(1), F11R(4), GNAI2(2), GRLF1(3), ICAM1(2), ITGA4(18), ITGAL(15), ITGAM(14), ITGB1(3), ITGB2(8), ITK(15), JAM2(6), JAM3(1), MAPK11(1), MAPK13(2), MAPK14(4), MLLT4(8), MMP2(3), MMP9(5), MYL2(4), MYL9(1), MYLPF(1), NCF2(4), NCF4(1), NOX1(6), NOX3(4), OCLN(2), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PLCG1(4), PLCG2(9), PRKCA(5), PRKCG(9), PTK2(2), PTK2B(7), PTPN11(3), PXN(3), RAC1(7), RAP1A(1), RAPGEF3(4), RAPGEF4(7), RASSF5(3), RHOH(3), ROCK1(2), ROCK2(4), SIPA1(4), TXK(5), VAV1(12), VAV2(3), VAV3(5), VCAM1(13), VCL(4) 18928934 424 81 413 229 304 23 10 50 35 2 0.121 1.000 1.000 175 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(1), APC(11), AR(7), BRAF(64), CCL15(2), CCL16(1), DAG1(3), EGFR(13), GNA11(2), GNA15(2), GNAQ(1), ITPKB(4), ITPR1(16), ITPR2(10), ITPR3(4), KCNJ3(11), KCNJ5(6), KCNJ9(2), MAPK1(2), MAPK10(5), MAPK14(4), PHKA2(5), PIK3CA(2), PIK3CD(2), PIK3R1(2), PITX2(1), RAF1(2) 8135343 185 81 134 85 91 15 7 59 13 0 0.323 1.000 1.000 176 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(1), AKT2(6), AKT3(2), CASP9(2), CHP(1), KDR(22), KRAS(1), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK11(1), MAPK13(2), MAPK14(4), MAPK3(1), MAPKAPK2(2), MAPKAPK3(1), NFAT5(3), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), NOS3(11), NRAS(29), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PLA2G12B(3), PLA2G2A(1), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(12), PLA2G4A(7), PLA2G6(7), PLCG1(4), PLCG2(9), PPP3CA(4), PPP3CB(1), PPP3R2(5), PRKCA(5), PRKCG(9), PTGS2(6), PTK2(2), PXN(3), RAC1(7), RAF1(2), SH2D2A(1), SHC2(4), SPHK1(1), SPHK2(5), VEGFA(1) 11049075 261 78 229 116 168 14 14 49 16 0 0.0453 1.000 1.000 177 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(1), AKT2(6), AKT3(2), BTK(6), CSF2(2), FCER1A(6), FCER1G(1), FYN(4), GAB2(1), GRB2(2), IL13(2), IL3(2), IL4(1), IL5(4), INPP5D(19), KRAS(1), LCP2(5), LYN(1), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP2K7(2), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(2), MAPK14(4), MAPK3(1), MAPK9(1), MS4A2(5), NRAS(29), PDK1(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PLA2G12B(3), PLA2G2A(1), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(12), PLA2G4A(7), PLA2G6(7), PLCG1(4), PLCG2(9), PRKCA(5), PRKCD(2), PRKCE(3), RAC1(7), RAF1(2), SOS1(4), SOS2(3), SYK(9), TNF(1), VAV1(12), VAV2(3), VAV3(5) 11068476 277 78 247 106 173 19 19 46 20 0 0.00178 1.000 1.000 178 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), AKT3(2), BCAR1(3), CAPN1(1), CAPN10(6), CAPN11(5), CAPN2(2), CAPN3(6), CAPN5(2), CAPN6(8), CAPN7(1), CAPN9(6), CAV1(1), CRK(2), CSK(1), DOCK1(11), FYN(4), GIT2(2), GRB2(2), ITGA10(2), ITGA11(12), ITGA2(7), ITGA2B(6), ITGA3(4), ITGA4(18), ITGA5(11), ITGA6(5), ITGA7(15), ITGA8(22), ITGA9(9), ITGAD(16), ITGAE(8), ITGAL(15), ITGAM(14), ITGAV(4), ITGAX(10), ITGB1(3), ITGB2(8), ITGB3(7), ITGB4(11), ITGB6(8), ITGB7(3), ITGB8(9), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K6(2), MAPK10(5), MAPK4(8), MAPK6(2), MAPK7(2), MYLK2(4), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PDPK1(1), PIK3R2(1), PTK2(2), PXN(3), RAC1(7), RAPGEF1(3), RHO(2), ROCK1(2), ROCK2(4), SDCCAG8(2), SEPP1(1), SHC3(7), SORBS1(6), SOS1(4), TLN1(10), TNS1(5), VAV2(3), VAV3(5), VCL(4), ZYX(3) 20358848 414 75 406 198 307 27 18 38 23 1 0.00854 1.000 1.000 179 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(2), ADCY1(16), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(9), ADCY6(5), ADCY7(6), ADCY8(26), ADK(3), ADSL(6), AK1(1), AK2(1), AK5(5), ALLC(3), AMPD1(19), AMPD2(2), AMPD3(14), ATIC(1), ATP1B1(1), ATP5A1(1), ATP5B(1), ATP5C1(1), ATP5F1(6), ATP5H(1), CANT1(4), DGUOK(4), ENPP1(7), ENPP3(8), ENTPD1(5), ENTPD2(3), FHIT(1), GART(5), GDA(5), GMPS(3), GUCY1A2(8), GUCY1A3(18), GUCY1B3(4), GUCY2C(16), GUCY2D(3), GUCY2F(7), IMPDH2(1), NPR1(12), NPR2(11), NT5E(3), NT5M(1), PAPSS1(1), PAPSS2(2), PDE1A(21), PDE4A(2), PDE4B(4), PDE4C(7), PDE4D(3), PDE5A(4), PDE6B(11), PDE6C(16), PDE6G(2), PDE7B(10), PDE8A(2), PDE9A(4), PFAS(2), PKLR(6), PKM2(4), POLD1(2), POLD2(1), POLE(9), POLG(4), POLL(6), POLQ(12), POLR1B(4), POLR2A(8), POLR2B(10), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2L(1), POLRMT(1), PRPS1(1), PRPS1L1(7), PRPS2(1), PRUNE(1), RRM1(2) 19609160 444 75 426 217 317 32 11 37 47 0 0.00292 1.000 1.000 180 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(18), ASH2L(2), CARM1(2), CTCFL(10), DOT1L(4), EED(2), EHMT1(5), EHMT2(3), EZH1(2), EZH2(6), FBXO11(1), HCFC1(9), JMJD4(2), JMJD6(1), MEN1(2), MLL(19), MLL2(30), MLL3(28), MLL4(23), MLL5(3), NSD1(8), OGT(3), PAXIP1(1), PPP1CA(1), PPP1CB(3), PPP1CC(1), PRDM2(9), PRDM7(2), PRDM9(28), PRMT5(3), PRMT6(1), PRMT7(1), PRMT8(7), RBBP5(4), SATB1(8), SETD1A(15), SETD2(9), SETD7(1), SETDB1(1), SETDB2(2), SETMAR(3), STK38(2), SUV420H1(3), SUV420H2(1), SUZ12(2), WHSC1(4), WHSC1L1(3) 18136212 298 74 295 116 198 36 8 32 24 0 0.0757 1.000 1.000 181 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(3), ATM(8), BUB1B(5), CCNA1(7), CCNB2(1), CCNB3(16), CCND2(3), CCNE1(1), CCNE2(10), CCNH(1), CDAN1(4), CDC14A(2), CDC14B(1), CDC25A(5), CDC25B(1), CDC25C(3), CDC6(1), CDC7(2), CDH1(4), CDK4(2), CDKN1A(1), CDKN2A(16), CHEK1(1), DTX4(2), E2F1(5), E2F2(1), E2F3(2), EP300(7), ESPL1(10), GSK3B(1), HDAC1(1), HDAC3(3), HDAC4(8), HDAC5(3), HDAC6(1), HDAC8(2), MAD1L1(2), MCM2(7), MCM3(5), MCM4(2), MCM5(2), MCM6(2), MDM2(2), MPEG1(5), MPL(1), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(1), ORC5L(1), ORC6L(2), PCNA(1), PRKDC(11), PTPRA(2), PTTG1(1), PTTG2(3), RB1(3), RBL1(4), TBC1D8(4), TP53(20) 16868148 229 74 218 81 138 17 10 28 34 2 0.00136 1.000 1.000 182 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 65 ATM(8), CCNA1(7), CCND2(3), CCNE1(1), CCNE2(10), CCNH(1), CDC25A(5), CDK4(2), CDKN1A(1), CDKN2A(16), CREB3L1(2), CREB3L3(5), CREB3L4(1), E2F1(5), E2F2(1), E2F3(2), GBA2(2), MCM2(7), MCM3(5), MCM4(2), MCM5(2), MCM6(2), MDM2(2), MNAT1(2), MYC(2), MYT1(12), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(1), ORC5L(1), ORC6L(2), PCNA(1), POLA2(6), POLE(9), POLE2(1), PRIM1(1), RB1(3), RBL1(4), RPA1(1), TFDP2(3), TNXB(65), TP53(20) 12192720 230 74 220 86 147 10 4 29 38 2 0.00320 1.000 1.000 183 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AKT1(1), AKT2(6), AKT3(2), APAF1(3), ATM(8), BAX(1), BCL2(2), BIRC2(4), BIRC3(5), CAPN1(1), CAPN2(2), CASP10(3), CASP7(3), CASP8(1), CASP9(2), CFLAR(3), CHP(1), CHUK(1), CSF2RB(8), CYCS(1), DFFA(1), DFFB(2), FAS(3), FASLG(10), IKBKB(2), IL1A(2), IL1B(2), IL1R1(6), IL1RAP(2), IL3(2), IL3RA(4), IRAK2(8), IRAK3(5), IRAK4(2), MAP3K14(1), MYD88(1), NFKB1(1), NFKB2(3), NFKBIA(1), NTRK1(9), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PPP3CA(4), PPP3CB(1), PPP3R2(5), PRKACA(2), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), RELA(1), RIPK1(1), TNF(1), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10C(3), TNFRSF10D(4), TNFRSF1A(2), TNFSF10(5), TP53(20), TRAF2(1) 12761197 228 74 224 116 145 12 13 31 27 0 0.345 1.000 1.000 184 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(2), ACTB(3), ACTG1(3), ACTN1(2), ACTN2(14), ACTN3(5), ACTN4(2), ACVR1B(3), ACVR1C(7), BAIAP2(2), CDH1(4), CREBBP(12), CSNK2B(1), CTNNA1(2), CTNNA2(14), CTNNA3(13), CTNNB1(5), CTNND1(7), EGFR(13), EP300(7), ERBB2(2), FARP2(2), FER(1), FGFR1(6), FYN(4), IGF1R(5), INSR(11), IQGAP1(7), LEF1(1), LMO7(17), MAPK1(2), MAPK3(1), MET(7), MLLT4(8), NLK(2), PARD3(9), PTPN1(1), PTPN6(1), PTPRB(52), PTPRF(15), PTPRJ(4), PTPRM(4), PVRL1(3), PVRL2(2), PVRL3(1), PVRL4(4), RAC1(7), SMAD2(1), SNAI1(1), SNAI2(1), SORBS1(6), SSX2IP(3), TCF7L1(1), TCF7L2(3), TGFBR2(5), TJP1(5), VCL(4), WAS(4), WASF1(1), WASF2(4), WASF3(9), WASL(1), YES1(3) 18458296 352 74 337 186 254 19 7 32 37 3 0.446 1.000 1.000 185 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(1), AKT2(6), AKT3(2), BCL10(1), BLNK(10), BTK(6), CARD11(18), CD19(3), CD22(15), CD72(4), CD79A(1), CD81(2), CHP(1), CHUK(1), CR2(16), FCGR2B(1), FOS(1), GSK3B(1), IKBKB(2), INPP5D(19), JUN(1), KRAS(1), LILRB3(4), LYN(1), MALT1(2), NFAT5(3), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(1), NRAS(29), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PLCG2(9), PPP3CA(4), PPP3CB(1), PPP3R2(5), PTPN6(1), RAC1(7), RASGRP3(7), SYK(9), VAV1(12), VAV2(3), VAV3(5) 11440800 278 74 247 116 171 15 21 47 24 0 0.0166 1.000 1.000 186 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(1), ACVR1B(3), ACVRL1(4), AKT1(1), AURKB(2), BMPR1A(1), BMPR2(3), CDKL1(3), CDKL2(2), CDS1(5), CDS2(2), CLK1(1), CLK2(2), COL4A3BP(1), CSNK2B(1), DGKA(1), DGKB(14), DGKD(3), DGKE(5), DGKG(8), DGKH(6), DGKQ(2), DGKZ(6), IMPA1(1), INPP1(2), INPP4A(4), INPP5A(2), INPPL1(9), ITPKB(4), MAP3K10(5), MOS(5), NEK1(5), NEK3(1), OCRL(2), PAK4(3), PIK3C2A(3), PIK3C2B(7), PIK3C2G(20), PIK3CA(2), PIK3CB(10), PIK3CG(12), PIM2(1), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), PLCD1(2), PLCG1(4), PLCG2(9), PRKACA(2), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCH(2), PRKCQ(12), PRKCZ(1), PRKD1(1), PRKG1(5), RAF1(2), RPS6KA1(2), RPS6KA2(4), RPS6KA4(2), RPS6KB1(1), STK11(2) 17207911 325 73 313 187 231 18 12 29 35 0 0.660 1.000 1.000 187 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(2), BRAF(64), CREB5(7), DUSP4(1), DUSP6(1), EEF2K(2), GRB2(2), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK3(1), MKNK1(5), MKNK2(2), MOS(5), NFKB1(1), RAP1A(1), RPS6KA1(2), RPS6KA2(4), SOS1(4), SOS2(3), TRAF3(3) 4516827 117 73 66 35 50 6 4 53 4 0 0.0893 1.000 1.000 188 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 IMPA1(1), IMPA2(1), INPP1(2), INPP4A(4), INPP5A(2), INPP5B(3), INPPL1(9), IPMK(2), ISYNA1(1), ITPK1(4), ITPKB(4), MIOX(3), OCRL(2), PI4KA(7), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIP4K2A(3), PIP4K2B(2), PIP4K2C(1), PIP5K1A(6), PIP5K1B(11), PIP5K1C(4), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), PLCD1(2), PLCD3(1), PLCD4(1), PLCE1(22), PLCG1(4), PLCG2(9), PLCZ1(8), PTEN(11), SYNJ1(8), SYNJ2(9) 11314892 240 72 232 120 166 11 14 27 22 0 0.131 1.000 1.000 189 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(5), ABCA10(13), ABCA12(30), ABCA13(33), ABCA2(6), ABCA3(11), ABCA4(31), ABCA5(4), ABCA6(20), ABCA7(5), ABCA8(22), ABCA9(11), ABCB1(22), ABCB10(1), ABCB11(27), ABCB4(8), ABCB5(20), ABCB6(1), ABCB7(4), ABCB8(2), ABCB9(1), ABCC1(7), ABCC10(7), ABCC11(9), ABCC12(12), ABCC2(6), ABCC3(17), ABCC4(7), ABCC5(3), ABCC6(11), ABCC8(20), ABCC9(30), ABCD2(6), ABCD3(5), ABCG1(6), ABCG2(6), ABCG4(5), ABCG5(4), ABCG8(11), CFTR(24), TAP1(1), TAP2(11) 18070427 485 72 469 289 345 33 13 45 49 0 0.0739 1.000 1.000 190 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(2), ACADL(2), ACADM(3), ACOX1(3), ACOX2(6), ACOX3(5), ACSL1(2), ACSL3(3), ACSL5(8), ACSL6(4), ADIPOQ(1), ANGPTL4(3), APOA1(1), APOA5(2), AQP7(3), CD36(3), CPT1A(6), CPT1B(4), CPT1C(11), CPT2(1), CYP27A1(2), CYP4A11(12), CYP4A22(16), CYP7A1(4), CYP8B1(5), EHHADH(5), FABP1(3), FABP2(5), FABP3(1), FABP4(1), FADS2(2), GK(4), GK2(13), HMGCS2(11), LPL(2), ME1(11), MMP1(4), NR1H3(2), OLR1(3), PCK1(15), PCK2(2), PDPK1(1), PPARA(3), PPARD(1), PPARG(6), RXRA(1), RXRB(1), RXRG(1), SCD(2), SLC27A1(3), SLC27A2(5), SLC27A4(4), SLC27A5(3), SLC27A6(13), SORBS1(6), UBC(3), UCP1(4) 10092663 253 72 245 154 190 21 10 12 19 1 0.503 1.000 1.000 191 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(1), AKT2(6), AKT3(2), CASP8(1), CD14(3), CD40(1), CD86(12), CHUK(1), CXCL10(2), CXCL11(1), CXCL9(2), FOS(1), IFNA10(1), IFNA14(4), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(6), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR2(3), IFNB1(4), IKBKB(2), IKBKE(5), IL12A(2), IL12B(3), IL1B(2), IL8(1), IRAK4(2), IRF3(1), IRF5(2), IRF7(3), JUN(1), LBP(5), LY96(3), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP2K7(2), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(2), MAPK14(4), MAPK3(1), MAPK9(1), MYD88(1), NFKB1(1), NFKB2(3), NFKBIA(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), RAC1(7), RELA(1), RIPK1(1), SPP1(3), STAT1(2), TBK1(2), TICAM1(5), TLR1(5), TLR2(8), TLR3(6), TLR4(21), TLR5(11), TLR6(3), TLR7(3), TLR8(4), TLR9(7), TNF(1), TOLLIP(1), TRAF3(3), TRAF6(2) 13747130 268 72 261 142 188 19 12 31 18 0 0.170 1.000 1.000 192 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(11), AMY2A(3), AMY2B(5), ENPP1(7), ENPP3(8), G6PC(4), GAA(3), GANAB(4), GBA3(5), GBE1(7), GCK(8), GPI(2), GUSB(2), GYS1(2), GYS2(10), HK1(1), HK2(4), HK3(10), MGAM(71), PGM1(2), PGM3(1), PYGB(2), PYGL(2), PYGM(6), SI(34), UCHL1(4), UCHL3(1), UGT1A1(1), UGT1A10(10), UGT1A3(6), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(7), UGT1A8(2), UGT1A9(5), UGT2B15(16), UGT2B4(18), UXS1(1) 8688570 296 72 281 124 211 27 11 22 25 0 0.00270 1.000 1.000 193 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 A4GNT(3), ALG1(2), ALG10B(3), ALG12(1), ALG13(3), ALG2(3), ALG3(1), ALG8(2), ALG9(3), B3GNT1(1), B3GNT2(2), B3GNT7(3), B4GALT2(2), B4GALT3(1), B4GALT5(1), C1GALT1(4), C1GALT1C1(1), CHPF(2), CHST1(7), CHST11(4), CHST12(1), CHST13(1), CHST14(2), CHST2(1), CHST4(6), CHST6(4), CHSY1(5), DDOST(1), DPAGT1(1), EXT2(2), EXTL3(2), FUT11(1), FUT8(4), GALNT1(2), GALNT10(2), GALNT11(1), GALNT12(5), GALNT13(9), GALNT14(14), GALNT2(4), GALNT3(2), GALNT4(2), GALNT5(7), GALNT6(11), GALNT7(4), GALNT8(14), GALNTL1(2), GALNTL2(10), GALNTL4(1), GALNTL5(13), GANAB(4), GCNT1(4), GCNT3(3), HS2ST1(1), HS3ST1(6), HS3ST2(6), HS3ST3B1(2), HS3ST5(5), HS6ST1(1), HS6ST2(1), HS6ST3(9), MAN1A1(8), MAN1A2(3), MAN1B1(2), MAN1C1(4), MAN2A1(6), MGAT3(8), MGAT4A(5), MGAT5(1), MGAT5B(6), NDST1(2), NDST3(13), NDST4(29), OGT(3), RPN2(2), ST3GAL1(5), ST6GAL1(4), ST6GALNAC1(3), STT3B(2), WBSCR17(20), XYLT1(8), XYLT2(1) 16758922 360 71 352 181 257 32 10 27 34 0 0.0178 1.000 1.000 194 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(3), ATM(8), ATR(13), BAI1(10), BAX(1), CASP8(1), CASP9(2), CCNB2(1), CCNB3(16), CCND2(3), CCNE1(1), CCNE2(10), CCNG1(1), CDK4(2), CDKN1A(1), CDKN2A(16), CHEK1(1), CYCS(1), DDB2(2), EI24(1), FAS(3), GADD45B(1), GTSE1(5), IGF1(6), IGFBP3(1), LRDD(1), MDM2(2), MDM4(1), PERP(1), PPM1D(2), PTEN(11), RFWD2(2), RRM2B(1), SERPINB5(8), SERPINE1(2), SESN2(3), SESN3(1), SFN(1), STEAP3(2), THBS1(15), TNFRSF10B(1), TP53(20), TP73(4), TSC2(6) 9953517 194 71 183 90 112 7 10 27 38 0 0.287 1.000 1.000 195 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(6), AGTR2(2), ATP8A1(13), AVPR1A(2), AVPR1B(5), BDKRB1(4), BDKRB2(2), BRS3(2), C3AR1(2), CCKAR(8), CCKBR(8), CCR1(5), CCR10(1), CCR2(6), CCR3(7), CCR4(4), CCR5(4), CCR6(1), CCR7(2), CCR8(2), CX3CR1(9), CXCR3(2), CXCR6(4), EDNRA(3), EDNRB(3), FPR1(15), FSHR(9), GALR1(3), GALT(2), GHSR(5), GNB2L1(1), GNRHR(2), GPR77(3), GRPR(2), LHCGR(10), MC2R(2), MC3R(6), MC4R(1), MC5R(4), NMBR(2), NPY1R(10), NPY2R(8), NPY5R(11), NTSR1(3), NTSR2(1), OPRK1(14), OPRL1(3), OPRM1(4), OXTR(3), PPYR1(9), SSTR1(5), SSTR2(1), SSTR3(9), SSTR4(1), TACR1(3), TACR2(3), TACR3(16), TRHR(9), TSHR(6) 8037551 293 71 287 217 205 24 13 27 24 0 0.0666 1.000 1.000 196 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(1), ACVR1B(3), ACVR1C(7), ACVR2A(1), ACVR2B(1), ACVRL1(4), AMHR2(7), BMP2(3), BMP4(1), BMP5(9), BMP6(6), BMP7(2), BMPR1A(1), BMPR1B(2), BMPR2(3), CHRD(8), COMP(4), CREBBP(12), CUL1(2), DCN(11), EP300(7), FST(1), GDF5(8), GDF6(1), GDF7(2), ID2(2), IFNG(2), INHBA(10), INHBB(4), INHBC(6), INHBE(1), LEFTY1(2), LEFTY2(1), LTBP1(23), MAPK1(2), MAPK3(1), MYC(2), NODAL(1), PITX2(1), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(2), PPP2R2C(4), RBL1(4), RBL2(2), ROCK1(2), ROCK2(4), RPS6KB1(1), RPS6KB2(2), SMAD1(4), SMAD2(1), SMAD5(3), SMAD6(4), SMAD9(5), SMURF1(1), SMURF2(3), SP1(3), TGFB2(1), TGFB3(1), TGFBR2(5), THBS1(15), THBS2(5), THBS3(7), THBS4(7), TNF(1), ZFYVE16(2), ZFYVE9(4) 15245536 266 70 263 154 177 28 11 22 28 0 0.844 1.000 1.000 197 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(29), COL4A2(20), COL4A3(16), COL4A4(50), COL4A5(32), COL4A6(21), F10(2), F11(8), F12(1), F2(6), F2R(3), F5(19), F8(21), F9(6), FGA(19), FGB(6), FGG(3), KLKB1(15), PROC(7), PROS1(8), SERPINC1(5), SERPING1(7) 6810064 304 70 296 96 243 16 11 20 14 0 0.157 1.000 1.000 198 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(4), AKR1D1(9), ARSD(1), ARSE(2), CARM1(2), CYP11B1(7), CYP11B2(8), CYP19A1(5), HEMK1(1), HSD11B1(6), HSD17B2(6), HSD17B3(5), HSD3B1(1), HSD3B2(9), LCMT1(3), METTL2B(5), PRMT2(1), PRMT3(3), PRMT5(3), PRMT6(1), PRMT7(1), PRMT8(7), SRD5A1(2), SRD5A2(4), STS(1), SULT1E1(7), SULT2A1(4), SULT2B1(5), UGT1A1(1), UGT1A10(10), UGT1A3(6), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(7), UGT1A8(2), UGT1A9(5), UGT2A1(8), UGT2A3(14), UGT2B10(17), UGT2B11(10), UGT2B15(16), UGT2B28(14), UGT2B4(18), UGT2B7(8) 7634744 260 69 250 114 181 23 11 15 30 0 0.00247 1.000 1.000 199 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), AGK(1), AGPAT2(3), AGPAT3(3), AGPAT4(4), AKR1B1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2), CEL(4), DAK(2), DGAT2(2), DGKA(1), DGKB(14), DGKD(3), DGKE(5), DGKG(8), DGKH(6), DGKI(12), DGKQ(2), DGKZ(6), GK(4), GK2(13), GLB1(5), GPAM(5), LCT(24), LIPC(5), LIPF(6), LIPG(5), LPL(2), MGLL(3), PNLIP(4), PNLIPRP1(8), PNLIPRP2(1), PNPLA3(1), PPAP2B(4), PPAP2C(5) 9043877 251 69 238 117 180 23 10 20 18 0 0.0175 1.000 1.000 200 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(2), ACADL(2), ACADM(3), ACADSB(3), ACAT2(1), ACOX1(3), ACOX3(5), ACSL1(2), ACSL3(3), ACSL5(8), ACSL6(4), ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2), CPT1A(6), CPT1B(4), CPT1C(11), CPT2(1), CYP4A11(12), CYP4A22(16), DCI(2), EHHADH(5), GCDH(3), HADHA(7), HADHB(2), HSD17B10(1), HSD17B4(3), PECI(1) 7564273 188 68 178 85 137 16 10 12 12 1 0.0280 1.000 1.000 201 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(1), CREBBP(12), DLL1(2), DLL3(4), DLL4(4), DTX1(5), DTX2(3), DTX3(1), DTX3L(5), DTX4(2), DVL2(2), DVL3(4), EP300(7), HDAC1(1), HES1(1), JAG1(5), JAG2(4), LFNG(3), MAML1(2), MAML2(2), MAML3(6), MFNG(5), NCOR2(14), NCSTN(2), NOTCH1(3), NOTCH2(22), NOTCH3(14), NOTCH4(35), NUMB(2), NUMBL(2), PSEN2(2), PTCRA(1), RBPJ(2), RBPJL(1), SNW1(2) 10547293 183 68 183 97 104 23 6 34 16 0 0.718 1.000 1.000 202 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(1), CDC40(3), CLK2(2), COL2A1(17), CPSF1(3), CPSF2(1), CPSF3(2), CSTF1(5), CSTF2(2), CSTF2T(2), CSTF3(3), DDIT3(1), DDX20(6), DHX15(1), DHX16(4), DHX38(5), DHX8(4), DHX9(4), DICER1(11), DNAJC8(2), GIPC1(2), LOC440563(12), LSM7(1), METTL3(1), NCBP1(1), NONO(4), NUDT21(2), NXF1(2), PABPN1(1), PAPOLA(3), POLR2A(8), PRPF18(2), PRPF3(1), PRPF4(3), PRPF4B(2), PRPF8(9), PSKH1(2), PTBP1(1), PTBP2(4), RBM17(1), RBM5(4), RNGTT(1), RNMT(6), SF3A1(4), SF3A2(2), SF3A3(2), SF3B1(8), SF3B2(6), SF3B4(4), SF4(3), SFRS12(2), SFRS14(6), SFRS16(5), SFRS5(1), SFRS6(1), SFRS8(1), SFRS9(2), SNRPB(4), SNRPB2(1), SNRPN(3), SNURF(1), SPOP(1), SRPK1(4), SRPK2(2), SRRM1(5), SUPT5H(4), XRN2(3) 16370387 227 68 227 87 156 16 12 26 17 0 0.0725 1.000 1.000 203 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ABP1(10), ACAT2(1), ACMSD(5), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH9A1(2), AOC2(5), AOC3(5), AOX1(13), ASMT(3), CAT(3), CYP19A1(5), CYP1A1(8), CYP1A2(8), CYP2A13(4), CYP2A6(7), CYP2A7(5), CYP2B6(9), CYP2C18(17), CYP2C19(25), CYP2C8(18), CYP2C9(24), CYP2D6(1), CYP2E1(8), CYP2F1(6), CYP2J2(3), CYP3A4(12), CYP3A5(4), CYP3A7(12), CYP4B1(8), CYP4F8(7), CYP51A1(1), DDC(5), EHHADH(5), GCDH(3), HAAO(1), HADHA(7), KMO(4), KYNU(5), MAOA(2), MAOB(7), TDO2(2), TPH1(1), WARS(3), WARS2(1) 8409520 307 68 296 180 247 17 12 16 15 0 0.116 1.000 1.000 204 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(10), ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), ALDH1A3(2), ALDH3A1(3), ALDH3B1(1), ALDH3B2(4), AOC2(5), AOC3(5), AOX1(13), CARM1(2), COMT(1), DBH(5), DCT(1), DDC(5), ECH1(1), FAH(4), GOT1(4), GOT2(2), HEMK1(1), HGD(10), HPD(2), LCMT1(3), MAOA(2), MAOB(7), METTL2B(5), MYST3(9), MYST4(11), NAT6(2), PNMT(3), PNPLA3(1), PRMT2(1), PRMT3(3), PRMT5(3), PRMT6(1), PRMT7(1), PRMT8(7), SH3GLB1(1), TAT(10), TH(6), TPO(28), TYR(2), TYRP1(3) 9122120 254 67 243 135 194 21 14 13 12 0 0.176 1.000 1.000 205 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(1), AKT2(6), AKT3(2), CDKN2A(16), CREB5(7), ERBB4(26), F2RL2(3), GAB1(3), GRB2(2), GSK3B(1), IFI27(2), IGF1(6), IGFBP1(1), INPPL1(9), IRS1(2), IRS4(5), MET(7), MYC(2), NOLC1(2), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PAK7(27), PARD3(9), PDK1(1), PIK3CA(2), PIK3CD(2), PPP1R13B(3), PREX1(1), PTEN(11), PTK2(2), PTPN1(1), RPS6KA1(2), RPS6KA2(4), RPS6KB1(1), SFN(1), SLC2A4(2), SOS1(4), SOS2(3), TSC1(3), TSC2(6), YWHAG(1), YWHAQ(1) 11862825 204 67 196 104 124 17 11 22 30 0 0.484 1.000 1.000 206 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(10), CCKBR(8), CCR2(6), CCR3(7), CCR5(4), CELSR1(18), CELSR2(14), CELSR3(14), CHRM2(7), CHRM3(10), CXCR3(2), DRD4(1), EDNRA(3), EMR2(1), EMR3(14), F2R(3), FSHR(9), GHRHR(4), GNRHR(2), GPR116(20), GPR132(1), GPR133(6), GPR143(2), GPR55(4), GPR56(3), GPR77(3), GPR84(4), GRM1(7), GRPR(2), HRH4(4), LGR6(9), LPHN2(22), LPHN3(8), NTSR1(3), OR2M4(8), OR8G2(5), P2RY13(2), PTGFR(12), SMO(4), SSTR2(1), TAAR5(1), TSHR(6) 10199852 274 66 267 193 189 21 11 32 21 0 0.449 1.000 1.000 207 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(3), ADCY4(1), ADCY6(5), ADCY8(26), CACNA1A(19), CACNA1B(18), GNAS(12), GNAT3(3), GNB3(5), GRM4(13), ITPR3(4), KCNB1(13), PDE1A(21), PLCB2(4), PRKACA(2), PRKACB(2), PRKACG(5), PRKX(1), SCNN1A(5), SCNN1B(10), SCNN1G(16), TAS1R1(5), TAS1R2(12), TAS1R3(1), TAS2R1(5), TAS2R10(4), TAS2R13(2), TAS2R14(1), TAS2R16(3), TAS2R38(11), TAS2R39(7), TAS2R4(1), TAS2R40(3), TAS2R41(6), TAS2R46(1), TAS2R5(1), TAS2R60(11), TAS2R7(2), TAS2R8(3), TAS2R9(2), TRPM5(7) 8681102 276 66 265 232 195 16 9 32 24 0 0.890 1.000 1.000 208 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(1), AKT2(6), AKT3(2), BCR(6), BTK(6), CD19(3), CDKN2A(16), DAPP1(2), FLOT1(1), GAB1(3), ITPR1(16), ITPR2(10), ITPR3(4), LYN(1), NR0B2(5), PDK1(1), PIK3CA(2), PITX2(1), PLCG2(9), PPP1R13B(3), PREX1(1), PTEN(11), PTPRC(18), RPS6KA1(2), RPS6KA2(4), RPS6KB1(1), SAG(4), SYK(9), TEC(6), VAV1(12) 8446171 166 66 156 93 101 14 9 14 28 0 0.411 1.000 1.000 209 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(3), BCL2(2), CABIN1(1), CALM2(1), CAMK2B(1), CAMK4(8), CD3E(2), CD69(3), CDKN1A(1), CNR1(7), CREBBP(12), CSF2(2), CSNK2B(1), CTLA4(1), EGR2(3), EGR3(1), EP300(7), FCER1A(6), FCGR3A(3), FOS(1), GATA3(8), GATA4(1), GRLF1(3), GSK3B(1), ICOS(2), IFNB1(4), IFNG(2), IL10(1), IL13(2), IL1B(2), IL2(4), IL2RA(4), IL3(2), IL4(1), IL8(1), ITK(15), KPNA5(1), MAP2K7(2), MAPK14(4), MAPK9(1), MEF2A(2), MEF2B(2), MEF2D(2), MYF5(7), NCK2(3), NFAT5(3), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), NFKB2(3), NFKBIB(1), NPPB(4), NUP214(7), P2RX7(3), PAK1(2), PPIA(1), PPP3CB(1), PTPRC(18), RELA(1), SFN(1), SLA(1), SP1(3), SP3(1), TNF(1), TRAF2(1), TRPV6(17), VAV1(12), VAV2(3), VAV3(5), XPO5(6) 13981478 259 65 250 131 193 21 8 17 20 0 0.163 1.000 1.000 210 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(7), CAD(11), CANT1(4), CDA(2), CTPS(1), CTPS2(2), DCTD(1), DHODH(1), DPYD(33), DPYS(13), ENTPD1(5), ENTPD3(3), ENTPD4(2), ENTPD6(2), ENTPD8(1), NME7(4), NT5C1B(16), NT5C3(2), NT5E(3), NT5M(1), PNPT1(1), POLA1(1), POLA2(6), POLD1(2), POLD2(1), POLD3(3), POLE(9), POLE2(1), POLR1A(7), POLR1B(4), POLR1C(1), POLR2A(8), POLR2B(10), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2L(1), POLR3A(2), POLR3B(10), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(8), RRM1(2), RRM2B(1), TXNRD1(1), TXNRD2(1), TYMS(1), UCK1(2), UMPS(1), UPB1(3), UPP2(4) 12448382 213 64 206 104 146 20 9 21 17 0 0.121 1.000 1.000 211 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(3), BAX(1), BTK(6), CAD(11), CASP10(3), CASP8(1), CASP8AP2(3), CDK2AP1(1), CSNK1A1(1), DAXX(4), DEDD(1), DEDD2(3), DFFA(1), DIABLO(1), EGFR(13), EPHB2(15), FAF1(3), FAIM2(4), HSPB1(1), IL1A(2), IL8(1), MAP2K4(3), MAP2K7(2), MAP3K5(9), MAPK1(2), MAPK10(5), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1), MET(7), NFAT5(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(1), NFKBIL1(3), NR0B2(5), PTPN13(7), RALBP1(1), RIPK1(1), ROCK1(2), SMPD1(1), TNFRSF6B(1), TP53(20), TPX2(7), TRAF2(1), TUFM(2) 11162946 179 64 175 101 119 10 11 20 19 0 0.663 1.000 1.000 212 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(3), AGT(3), AKT1(1), CALM2(1), CAMK1(4), CAMK1G(8), CAMK4(8), CREBBP(12), CSNK1A1(1), EDN1(6), F2(6), FKBP1A(2), GATA4(1), GSK3B(1), HAND2(3), IGF1(6), LIF(1), MAP2K1(3), MAPK1(2), MAPK14(4), MAPK3(1), MEF2C(2), MYH2(38), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), NPPA(1), PIK3CA(2), PIK3R1(2), PPP3CA(4), PPP3CB(1), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), RAF1(2), RPS6KB1(1), SYT1(11) 7806324 175 63 170 102 138 12 6 10 9 0 0.579 1.000 1.000 213 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(2), ACP2(2), ACP5(2), ACPP(4), ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), CYP19A1(5), CYP1A1(8), CYP1A2(8), CYP2A13(4), CYP2A6(7), CYP2A7(5), CYP2B6(9), CYP2C18(17), CYP2C19(25), CYP2C8(18), CYP2C9(24), CYP2D6(1), CYP2E1(8), CYP2F1(6), CYP2J2(3), CYP3A4(12), CYP3A5(4), CYP3A7(12), CYP4B1(8), CYP4F8(7), CYP51A1(1), PON1(8) 4457728 227 62 217 137 188 8 8 8 15 0 0.0467 1.000 1.000 214 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(4), CD4(3), CD74(3), CD8A(1), CD8B(4), CIITA(10), CTSS(3), HLA-A(1), HLA-B(4), HLA-C(1), HLA-DMA(2), HLA-DMB(3), HLA-DOA(3), HLA-DOB(1), HLA-DQA1(3), HLA-DQA2(2), HLA-DQB1(3), HLA-DRA(5), HLA-F(4), HLA-G(3), HSP90AA1(2), HSP90AB1(3), HSPA5(4), IFNA10(1), IFNA14(4), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(6), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(2), KIR2DL1(12), KIR2DL3(4), KIR2DL4(3), KIR2DS4(12), KIR3DL1(14), KIR3DL2(2), KIR3DL3(1), KLRC1(2), KLRC2(1), KLRC3(5), KLRC4(3), KLRD1(4), LGMN(4), LTA(2), NFYA(1), NFYB(1), PDIA3(2), PSME2(4), RFX5(2), RFXANK(1), TAP1(1), TAP2(11), TAPBP(1) 7079916 191 62 187 104 131 18 7 14 21 0 0.211 1.000 1.000 215 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(12), ACSL1(2), ACSL3(3), ACSL5(8), ACSL6(4), ADIPOQ(1), ADIPOR1(3), AKT1(1), AKT2(6), AKT3(2), CAMKK1(1), CAMKK2(3), CD36(3), CHUK(1), CPT1A(6), CPT1B(4), CPT1C(11), CPT2(1), G6PC(4), G6PC2(2), IKBKB(2), IRS1(2), IRS4(5), JAK1(4), JAK2(6), JAK3(5), LEP(1), LEPR(10), MAPK10(5), MAPK9(1), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(1), NPY(2), PCK1(15), PCK2(2), POMC(3), PPARA(3), PPARGC1A(14), PRKAA1(1), PRKAA2(15), PRKAB2(1), PRKAG1(1), PRKAG2(2), PRKAG3(5), PRKCQ(12), PTPN11(3), RELA(1), RXRA(1), RXRB(1), RXRG(1), SLC2A1(3), SLC2A4(2), SOCS3(2), STAT3(6), STK11(2), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(1), TYK2(3) 12748424 231 62 226 142 159 26 13 15 18 0 0.669 1.000 1.000 216 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(2), AKT1(1), AKT2(6), AKT3(2), ANGPTL2(2), ARHGAP1(1), ARHGAP4(1), ARHGEF11(9), BTK(6), GDI2(1), INPPL1(9), ITPR1(16), ITPR2(10), ITPR3(4), LIMK1(4), MYLK(17), MYLK2(4), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PAK7(27), PDK1(1), PIK3CA(2), PIK3CD(2), PIK3CG(12), PIK3R1(2), PITX2(1), PPP1R13B(3), PTEN(11), RHO(2), ROCK1(2), ROCK2(4), SAG(4), WASF1(1), WASL(1) 10719997 184 62 181 87 122 17 10 20 15 0 0.101 1.000 1.000 217 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(5), ABP1(10), ACADL(2), ACADM(3), ACADSB(3), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH9A1(2), AOC2(5), AOC3(5), CNDP1(7), DPYD(33), DPYS(13), EHHADH(5), GAD1(6), GAD2(3), HADHA(7), MLYCD(2), SMS(1), UPB1(3) 4470969 136 61 131 56 97 10 8 13 8 0 0.0173 1.000 1.000 218 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), AGPAT2(3), AGPAT3(3), AGPAT4(4), AKR1B1(2), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH9A1(2), CEL(4), DGKA(1), DGKB(14), DGKD(3), DGKE(5), DGKG(8), DGKH(6), DGKQ(2), DGKZ(6), GK(4), GLB1(5), LCT(24), LIPC(5), LIPF(6), LIPG(5), LPL(2), PNLIP(4), PNLIPRP1(8), PNLIPRP2(1), PPAP2B(4), PPAP2C(5) 7417786 221 61 209 101 159 22 9 16 15 0 0.0131 1.000 1.000 219 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(6), ALOX12(2), ALOX12B(4), ALOX15(4), ALOX15B(5), ALOX5(6), CYP2B6(9), CYP2C18(17), CYP2C19(25), CYP2C8(18), CYP2C9(24), CYP2E1(8), CYP2J2(3), CYP4A11(12), CYP4A22(16), CYP4F2(6), CYP4F3(11), EPHX2(4), GGT1(3), GPX1(2), GPX3(2), GPX5(6), GPX6(5), LTA4H(2), PLA2G12B(3), PLA2G2A(1), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(12), PLA2G4A(7), PLA2G6(7), PTGDS(1), PTGIS(8), PTGS1(12), PTGS2(6), TBXAS1(7) 5928424 273 61 265 185 216 17 5 18 16 1 0.463 1.000 1.000 220 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(11), AXIN1(6), CCND2(3), CSNK1E(3), CTNNB1(5), DVL2(2), DVL3(4), FBXW2(1), FZD1(1), FZD10(1), FZD2(2), FZD5(1), FZD6(2), FZD7(2), FZD8(3), GSK3B(1), JUN(1), LDLR(9), MAPK10(5), MAPK9(1), MYC(2), PAFAH1B1(2), PLAU(2), PPP2R5C(2), PPP2R5E(2), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCH(2), PRKCI(4), PRKCQ(12), PRKCZ(1), PRKD1(1), RAC1(7), SFRP4(3), WNT1(1), WNT10A(4), WNT10B(3), WNT11(2), WNT16(1), WNT2(5), WNT2B(1), WNT3(3), WNT4(2), WNT5A(4), WNT5B(2), WNT6(2), WNT7A(9), WNT7B(2) 9143672 164 61 159 96 107 15 3 19 20 0 0.571 1.000 1.000 221 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(3), AGT(3), AGTR1(6), AGTR2(2), CMA1(3), COL4A1(29), COL4A2(20), COL4A3(16), COL4A4(50), COL4A5(32), COL4A6(21), REN(7) 3866208 192 60 187 63 163 9 4 7 9 0 0.764 1.000 1.000 222 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP1(2), INPP4A(4), INPP5A(2), INPPL1(9), ITPKB(4), MIOX(3), OCRL(2), PIK3C2A(3), PIK3C2B(7), PIK3C2G(20), PIK3CA(2), PIK3CB(10), PIK3CG(12), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), PLCD1(2), PLCG1(4), PLCG2(9) 6844179 163 60 155 78 115 6 8 15 19 0 0.120 1.000 1.000 223 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(1), ATF2(5), DUSP10(6), DUSP4(1), DUSP8(1), GAB1(3), GCK(8), IL1R1(6), JUN(1), MAP2K4(3), MAP2K5(2), MAP2K7(2), MAP3K10(5), MAP3K11(3), MAP3K12(2), MAP3K13(5), MAP3K2(2), MAP3K3(3), MAP3K4(9), MAP3K5(9), MAP3K9(13), MAPK10(5), MAPK7(2), MAPK9(1), NFATC3(5), NR2C2(2), PAPPA(35), TP53(20), TRAF6(2), ZAK(4) 7715754 166 60 164 65 119 14 5 14 14 0 0.0731 1.000 1.000 224 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(10), ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), ALDH1A3(2), ALDH3A1(3), ALDH3B1(1), ALDH3B2(4), AOC2(5), AOC3(5), AOX1(13), COMT(1), DBH(5), DCT(1), DDC(5), FAH(4), GOT1(4), GOT2(2), HGD(10), HPD(2), MAOA(2), MAOB(7), PNMT(3), TAT(10), TH(6), TPO(28), TYR(2) 4848619 199 60 190 103 158 13 12 8 8 0 0.0347 1.000 1.000 225 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS2(3), ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH3B1(1), ALDH3B2(4), ALDH7A1(2), ALDH9A1(2), ALDOA(1), ALDOB(5), ALDOC(1), BPGM(1), DLAT(2), ENO1(2), ENO3(1), FBP1(1), G6PC(4), G6PC2(2), GALM(2), GCK(8), GPI(2), HK1(1), HK2(4), HK3(10), LDHA(2), LDHAL6B(5), LDHC(1), PDHA1(1), PDHA2(7), PDHB(1), PFKL(2), PGK1(1), PGK2(15), PGM1(2), PGM3(1), PKLR(6), PKM2(4) 8945952 181 59 171 89 137 11 8 9 16 0 0.0129 1.000 1.000 226 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(5), ABP1(10), ACADM(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2), AOC2(5), AOC3(5), CNDP1(7), DPYD(33), DPYS(13), EHHADH(5), GAD1(6), GAD2(3), HADHA(7), HIBCH(1), MLYCD(2), SMS(1), UPB1(3) 4158758 123 59 118 55 89 8 7 12 7 0 0.0507 1.000 1.000 227 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(3), ACTB(3), ACTG1(3), ARHGEF2(7), CD14(3), CDH1(4), CLDN1(5), CTNNB1(5), CTTN(1), EZR(1), FYN(4), HCLS1(7), ITGB1(3), KRT18(2), LY96(3), NCK2(3), NCL(3), OCLN(2), PRKCA(5), ROCK1(2), ROCK2(4), TLR4(21), TLR5(11), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(10), TUBA3D(5), TUBA3E(1), TUBA4A(3), TUBA8(1), TUBAL3(8), TUBB1(2), TUBB2A(1), TUBB3(3), TUBB4(1), TUBB4Q(4), TUBB6(5), TUBB8(6), WAS(4), WASL(1), YWHAQ(1) 8057064 165 59 160 70 118 15 5 16 11 0 0.0129 1.000 1.000 228 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(3), ACTB(3), ACTG1(3), ARHGEF2(7), CD14(3), CDH1(4), CLDN1(5), CTNNB1(5), CTTN(1), EZR(1), FYN(4), HCLS1(7), ITGB1(3), KRT18(2), LY96(3), NCK2(3), NCL(3), OCLN(2), PRKCA(5), ROCK1(2), ROCK2(4), TLR4(21), TLR5(11), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(10), TUBA3D(5), TUBA3E(1), TUBA4A(3), TUBA8(1), TUBAL3(8), TUBB1(2), TUBB2A(1), TUBB3(3), TUBB4(1), TUBB4Q(4), TUBB6(5), TUBB8(6), WAS(4), WASL(1), YWHAQ(1) 8057064 165 59 160 70 118 15 5 16 11 0 0.0129 1.000 1.000 229 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(3), AKT1(1), BDKRB2(2), CALM2(1), CAV1(1), CHRM1(4), CHRNA1(1), FLT1(17), FLT4(16), KDR(22), NOS3(11), PDE2A(7), PDE3A(13), PDE3B(3), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKG1(5), PRKG2(8), RYR2(42), SLC7A1(1), SYT1(11), TNNI1(1) 6246351 183 59 174 108 138 15 5 11 13 1 0.310 1.000 1.000 230 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(5), ALOX15(4), ALOX5(6), CYP1A2(8), CYP2C18(17), CYP2C19(25), CYP2C8(18), CYP2C9(24), CYP2E1(8), CYP2J2(3), CYP3A4(12), CYP3A43(8), CYP3A5(4), CYP3A7(12), PLA2G12B(3), PLA2G2A(1), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(12), PLA2G4A(7), PLA2G6(7), RDH12(1), RDH13(3) 3660662 197 58 191 113 159 8 6 11 13 0 0.103 1.000 1.000 231 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(3), ADAM17(1), ATP6V0A1(3), ATP6V0A4(11), ATP6V0D2(6), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(6), ATP6V1E2(1), ATP6V1F(1), ATP6V1G3(5), ATP6V1H(4), CHUK(1), CSK(1), EGFR(13), F11R(4), GIT1(4), IGSF5(5), IKBKB(2), IL8(1), JAM2(6), JAM3(1), JUN(1), LYN(1), MAP2K4(3), MAP3K14(1), MAPK10(5), MAPK11(1), MAPK13(2), MAPK14(4), MAPK9(1), MET(7), NFKB1(1), NFKB2(3), NFKBIA(1), NOD1(2), PAK1(2), PLCG1(4), PLCG2(9), PTPN11(3), PTPRZ1(13), RAC1(7), RELA(1), TCIRG1(2), TJP1(5) 10822309 162 58 158 115 112 13 5 18 14 0 0.970 1.000 1.000 232 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(8), BMPR1B(2), CCND2(3), CDK4(2), DAZL(3), DMC1(2), EGR1(1), ESR2(4), FSHR(9), GJA4(3), INHA(3), LHCGR(10), MLH1(5), MSH5(5), NCOR1(12), NR5A1(6), NRIP1(5), PGR(10), PRLR(17), PTGER2(4), SMPD1(1), VDR(2), ZP2(9) 5354401 126 58 115 67 90 6 3 13 14 0 0.629 1.000 1.000 233 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(1), AKT2(6), AKT3(2), BRD4(13), CBL(4), CDKN2A(16), F2RL2(3), FLOT1(1), GRB2(2), GSK3B(1), IGFBP1(1), INPPL1(9), IRS1(2), IRS4(5), LNPEP(9), MAPK1(2), MAPK3(1), PARD3(9), PDK1(1), PIK3CA(2), PIK3CD(2), PIK3R1(2), PPYR1(9), PTEN(11), PTPN1(1), RAF1(2), RPS6KA1(2), RPS6KA2(4), RPS6KB1(1), SERPINB6(1), SFN(1), SLC2A4(2), SORBS1(6), SOS1(4), SOS2(3), YWHAG(1), YWHAQ(1) 9162023 143 58 139 70 77 15 9 17 25 0 0.495 1.000 1.000 234 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(2), F11(8), F12(1), F13B(13), F2(6), F5(19), F7(2), F8(21), F9(6), FGA(19), FGB(6), FGG(3), LPA(24), PLAT(2), PLAU(2), PLG(14), SERPINB2(7), SERPINE1(2), SERPINF2(3), VWF(28) 5379988 188 57 184 87 136 14 10 10 17 1 0.214 1.000 1.000 235 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH3B1(1), ALDH3B2(4), ALDH9A1(2), ALDOA(1), ALDOB(5), ALDOC(1), BPGM(1), DLAT(2), ENO1(2), ENO3(1), FBP1(1), G6PC(4), GCK(8), GPI(2), HK1(1), HK2(4), HK3(10), LDHA(2), LDHC(1), PDHA1(1), PDHA2(7), PDHB(1), PGK1(1), PGM1(2), PGM3(1), PKLR(6), PKM2(4) 7510011 161 57 154 73 117 13 7 10 14 0 0.00678 1.000 1.000 236 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH3B1(1), ALDH3B2(4), ALDH9A1(2), ALDOA(1), ALDOB(5), ALDOC(1), BPGM(1), DLAT(2), ENO1(2), ENO3(1), FBP1(1), G6PC(4), GCK(8), GPI(2), HK1(1), HK2(4), HK3(10), LDHA(2), LDHC(1), PDHA1(1), PDHA2(7), PDHB(1), PGK1(1), PGM1(2), PGM3(1), PKLR(6), PKM2(4) 7510011 161 57 154 73 117 13 7 10 14 0 0.00678 1.000 1.000 237 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(3), BMP4(1), BMP5(9), BMP6(6), BMP7(2), BTRC(3), CSNK1A1(1), CSNK1A1L(3), CSNK1D(1), CSNK1E(3), CSNK1G1(1), CSNK1G2(2), FBXW11(4), GLI1(7), GLI2(20), GLI3(7), GSK3B(1), HHIP(13), IHH(2), LRP2(49), PRKACA(2), PRKACB(2), PRKACG(5), PRKX(1), PTCH1(3), PTCH2(9), SHH(2), SMO(4), STK36(9), SUFU(1), WNT1(1), WNT10A(4), WNT10B(3), WNT11(2), WNT16(1), WNT2(5), WNT2B(1), WNT3(3), WNT3A(5), WNT4(2), WNT5A(4), WNT5B(2), WNT6(2), WNT7A(9), WNT7B(2), WNT8A(4), WNT8B(4), WNT9A(1), WNT9B(3), ZIC2(1) 9238364 235 57 225 125 170 22 6 18 19 0 0.177 1.000 1.000 238 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(1), AKT2(6), AKT3(2), BCL2(2), BCR(6), BLNK(10), BTK(6), CD19(3), CD22(15), CD81(2), CR2(16), CSK(1), DAG1(3), FLOT1(1), GRB2(2), GSK3B(1), INPP5D(19), ITPR1(16), ITPR2(10), ITPR3(4), LYN(1), MAP4K1(3), MAPK1(2), MAPK3(1), NFATC1(9), NFATC2(4), NR0B2(5), PDK1(1), PIK3CA(2), PIK3CD(2), PIK3R1(2), PLCG2(9), PPP1R13B(3), PPP3CA(4), PPP3CB(1), PTPRC(18), RAF1(2), SOS1(4), SOS2(3), SYK(9), VAV1(12) 11327445 223 57 217 112 157 22 11 14 19 0 0.0774 1.000 1.000 239 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(29), COL4A2(20), COL4A3(16), COL4A4(50), COL4A5(32), COL4A6(21), P4HB(2), SLC23A1(2), SLC23A2(1), SLC2A1(3), SLC2A3(4) 3820501 180 57 175 52 152 7 7 7 7 0 0.269 1.000 1.000 240 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM2(1), CAMK1(4), CAMK1G(8), FPR1(15), GNA15(2), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K6(2), MAPK1(2), MAPK14(4), MAPK3(1), NCF2(4), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), NFKB1(1), NFKBIA(1), PAK1(2), PIK3C2G(20), PLCB1(29), PPP3CA(4), PPP3CB(1), RAC1(7), RAF1(2), RELA(1), SYT1(11) 5835018 152 56 144 73 118 9 5 9 11 0 0.191 1.000 1.000 241 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(11), CANT1(4), CDA(2), CTPS(1), CTPS2(2), DCTD(1), DHODH(1), DPYD(33), DPYS(13), ENTPD1(5), NT5E(3), NT5M(1), POLD1(2), POLD2(1), POLE(9), POLG(4), POLL(6), POLQ(12), POLR1B(4), POLR2A(8), POLR2B(10), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2L(1), POLRMT(1), RRM1(2), TXNRD1(1), TYMS(1), UCK1(2), UMPS(1), UNG(2), UPB1(3) 8816508 152 56 146 66 106 11 7 15 13 0 0.0321 1.000 1.000 242 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(28), B3GALT4(1), CDR1(3), DGKI(12), IL6ST(4), MRPL19(1), PIGK(3), RPL10(2), RPL11(1), RPL14(1), RPL15(2), RPL18(2), RPL18A(1), RPL21(1), RPL22(1), RPL26(1), RPL27(2), RPL27A(1), RPL3(1), RPL30(1), RPL38(1), RPL3L(3), RPL4(4), RPL5(3), RPL7(2), RPL7A(1), RPLP0(1), RPS10(1), RPS13(1), RPS2(1), RPS20(1), RPS24(1), RPS27(1), RPS29(1), RPS5(1), RPS6(1), RPS6KA1(2), RPS6KA2(4), RPS6KA6(3), RPS6KB1(1), RPS6KB2(2), RPS7(1), RPSA(1), SLC36A2(5), TBC1D10C(3), TSPAN9(1), UBC(3) 7964926 119 56 118 82 73 14 6 16 10 0 0.946 1.000 1.000 243 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(3), ACTG2(1), ACTR2(2), AKT1(1), ANGPTL2(2), FLNA(5), FLNC(31), FSCN1(4), FSCN2(1), FSCN3(7), GDI2(1), LIMK1(4), MYH2(38), MYLK(17), MYLK2(4), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PAK7(27), RHO(2), ROCK1(2), ROCK2(4), WASF1(1), WASL(1) 7318142 172 56 165 94 127 24 4 10 7 0 0.121 1.000 1.000 244 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(4), CD3D(4), CSK(1), CTLA4(1), DAG1(3), EPHB2(15), FBXW7(7), GRAP2(1), GRB2(2), ITK(15), ITPKB(4), LCK(4), LCP2(5), MAPK1(2), NFAT5(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(1), NFKBIL1(3), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PAK7(27), PLCG1(4), PTPRC(18), RAF1(2), RASGRP1(6), RASGRP2(2), RASGRP3(7), RASGRP4(7), SOS1(4), SOS2(3), VAV1(12), ZAP70(4) 8492419 190 56 183 98 133 12 9 21 15 0 0.351 1.000 1.000 245 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(3), BAX(1), BCL2(2), BCL2L11(2), BIRC2(4), BIRC3(5), BNIP3L(2), CASP1(3), CASP10(3), CASP2(1), CASP4(1), CASP7(3), CASP8(1), CASP9(2), CHUK(1), CYCS(1), DFFA(1), DFFB(2), FAS(3), FASLG(10), GZMB(1), HELLS(3), IKBKB(2), IRF2(3), IRF3(1), IRF4(1), IRF5(2), IRF6(5), IRF7(3), JUN(1), LTA(2), MAP2K4(3), MAPK10(5), MDM2(2), MYC(2), NFKB1(1), NFKBIA(1), NFKBIB(1), PLEKHG5(8), PRF1(5), RELA(1), RIPK1(1), TNF(1), TNFRSF10B(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(6), TNFRSF25(3), TNFSF10(5), TP53(20), TP73(4), TRAF1(4), TRAF2(1), TRAF3(3) 8774440 156 55 154 83 105 12 10 13 16 0 0.411 1.000 1.000 246 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(10), AGMAT(2), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH4A1(4), ALDH9A1(2), AOC2(5), AOC3(5), ASL(2), CKM(1), CKMT1A(1), CKMT2(5), CPS1(12), DAO(6), GAMT(2), GATM(1), GLUD1(1), GOT1(4), GOT2(2), MAOA(2), MAOB(7), NOS1(32), NOS3(11), OAT(1), ODC1(2), OTC(2), P4HA1(6), P4HA2(4), P4HA3(7), P4HB(2), RARS(4), SMS(1) 6748735 167 55 164 93 119 17 11 7 13 0 0.190 1.000 1.000 247 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(3), ALAS2(2), BLVRA(1), BLVRB(1), COX10(3), COX15(1), CP(8), CPOX(2), EPRS(4), FECH(1), FTH1(2), FTMT(3), GUSB(2), HCCS(1), HMBS(1), HMOX1(1), MMAB(2), PPOX(2), UGT1A1(1), UGT1A10(10), UGT1A3(6), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(7), UGT1A8(2), UGT1A9(5), UGT2A1(8), UGT2A3(14), UGT2B10(17), UGT2B11(10), UGT2B15(16), UGT2B28(14), UGT2B4(18), UGT2B7(8), UROS(1) 6457174 188 55 182 74 133 16 7 11 21 0 0.00593 1.000 1.000 248 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(2), ABO(4), B3GALNT1(4), B3GALT1(8), B3GALT2(1), B3GALT4(1), B3GALT5(1), B3GNT1(1), B3GNT2(2), B3GNT3(3), B3GNT4(2), B3GNT5(1), B4GALNT1(1), B4GALT2(2), B4GALT3(1), B4GALT6(1), FUT1(3), FUT2(1), FUT3(3), FUT4(1), FUT5(6), FUT6(1), FUT7(1), FUT9(13), GBGT1(1), PIGB(2), PIGC(1), PIGF(1), PIGG(9), PIGK(3), PIGL(2), PIGN(2), PIGO(6), PIGQ(5), PIGS(1), PIGT(1), PIGU(2), PIGV(4), PIGX(1), PIGZ(1), ST3GAL1(5), ST3GAL5(1), ST3GAL6(2), ST6GALNAC3(3), ST6GALNAC5(4), ST6GALNAC6(1), ST8SIA5(3) 7435104 125 55 125 74 82 13 6 13 11 0 0.385 1.000 1.000 249 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(6), ALOX12(2), ALOX15(4), ALOX5(6), CYP4F2(6), CYP4F3(11), EPX(4), GGT1(3), LPO(8), LTA4H(2), MPO(5), PLA2G2A(1), PLA2G2E(2), PLA2G3(12), PLA2G4A(7), PLA2G6(7), PRDX1(1), PRDX2(2), PRDX6(1), PTGDS(1), PTGIS(8), PTGS1(12), PTGS2(6), TBXAS1(7), TPO(28) 4284039 152 55 149 97 115 12 3 14 8 0 0.343 1.000 1.000 250 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(3), AKT1(1), APC(11), DAG1(3), DLG4(3), EPHB2(15), GNAQ(1), ITPR1(16), ITPR2(10), ITPR3(4), KCNJ3(11), KCNJ5(6), KCNJ9(2), MAPK1(2), PITX2(1), RAC1(7), RHO(2), RYR1(52) 6976722 150 55 146 106 112 14 6 8 10 0 0.686 1.000 1.000 251 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), GUSB(2), UGP2(1), UGT1A1(1), UGT1A10(10), UGT1A3(6), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(7), UGT1A8(2), UGT1A9(5), UGT2A1(8), UGT2A3(14), UGT2B10(17), UGT2B11(10), UGT2B15(16), UGT2B28(14), UGT2B4(18), UGT2B7(8), XYLB(2) 4165367 154 54 148 63 110 12 7 9 16 0 0.0229 1.000 1.000 252 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(3), AANAT(1), ABP1(10), ACAT2(1), ACMSD(5), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2), AOC2(5), AOC3(5), AOX1(13), ASMT(3), CARM1(2), CAT(3), CYP1A1(8), CYP1A2(8), CYP1B1(1), DDC(5), EHHADH(5), GCDH(3), HAAO(1), HADHA(7), HEMK1(1), HSD17B10(1), HSD17B4(3), INMT(4), KMO(4), KYNU(5), LCMT1(3), LNX1(11), MAOA(2), MAOB(7), METTL2B(5), NFX1(4), OGDH(7), OGDHL(22), PRMT2(1), PRMT3(3), PRMT5(3), PRMT6(1), PRMT7(1), PRMT8(7), TDO2(2), TPH1(1), TPH2(6), WARS(3), WARS2(1) 9289271 211 54 206 109 158 16 9 17 11 0 0.115 1.000 1.000 253 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(5), AGPAT2(3), AGPAT3(3), AGPAT4(4), CDS1(5), CDS2(2), CHAT(10), CHKA(2), CHKB(1), CHPT1(1), DGKA(1), DGKB(14), DGKD(3), DGKE(5), DGKG(8), DGKH(6), DGKI(12), DGKQ(2), DGKZ(6), GNPAT(1), GPAM(5), GPD1(6), GPD1L(1), GPD2(1), LYPLA1(1), LYPLA2(1), MYST3(9), MYST4(11), NAT6(2), PCYT1A(2), PCYT1B(2), PEMT(1), PISD(2), PLA2G12B(3), PLA2G2A(1), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(12), PLA2G4A(7), PLA2G6(7), PLD1(5), PLD2(2), PNPLA3(1), PPAP2B(4), PPAP2C(5), SH3GLB1(1) 10027795 195 54 188 106 139 16 5 18 17 0 0.441 1.000 1.000 254 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(3), CRK(2), DOCK1(11), FOS(1), GAB1(3), GRB2(2), HGF(8), ITGA1(14), ITGB1(3), JUN(1), MAP2K1(3), MAP2K2(2), MAP4K1(3), MAPK1(2), MAPK3(1), MET(7), PAK1(2), PIK3CA(2), PIK3R1(2), PTEN(11), PTK2(2), PTK2B(7), PTPN11(3), PXN(3), RAF1(2), RAP1A(1), RASA1(1), SOS1(4), STAT3(6) 6693195 112 54 109 55 69 6 6 17 14 0 0.707 1.000 1.000 255 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(3), C1QB(1), C1R(8), C1S(11), C2(8), C3(21), C5(5), C6(36), C7(17), C8A(23), C8B(25), C9(11), MASP1(5) 3156701 174 53 161 76 144 8 1 10 10 1 0.0235 1.000 1.000 256 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(33), GABBR1(4), GPRC5A(2), GPRC5B(1), GPRC5C(6), GPRC5D(2), GRM1(7), GRM2(1), GRM3(30), GRM4(13), GRM5(5), GRM7(18), GRM8(26) 3205913 148 53 142 109 113 11 5 10 9 0 0.414 1.000 1.000 257 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(21), C5(5), C6(36), C7(17), ICAM1(2), IL1A(2), IL8(1), ITGA4(18), ITGAL(15), ITGB1(3), ITGB2(8), SELP(13), SELPLG(3), TNF(1), VCAM1(13) 3772581 158 53 148 76 125 3 4 10 15 1 0.0909 1.000 1.000 258 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(1), AKT1(1), AKT2(6), AKT3(2), BTK(6), CDKN2A(16), DAPP1(2), GRB2(2), GSK3B(1), IARS(1), IGFBP1(1), INPP5D(19), PDK1(1), PIK3CA(2), PPP1R13B(3), PTEN(11), RPS6KA1(2), RPS6KA2(4), RPS6KB1(1), SFN(1), SOS1(4), SOS2(3), TEC(6), YWHAG(1), YWHAQ(1) 5536854 98 53 92 35 52 8 8 9 21 0 0.125 1.000 1.000 259 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(4), AKR1D1(9), ARSD(1), ARSE(2), CYP11B1(7), CYP11B2(8), HSD11B1(6), HSD17B2(6), HSD17B3(5), HSD3B1(1), HSD3B2(9), SRD5A1(2), SRD5A2(4), STS(1), SULT1E1(7), SULT2A1(4), UGT1A1(1), UGT1A10(10), UGT1A3(6), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(7), UGT1A8(2), UGT1A9(5), UGT2B15(16), UGT2B4(18) 4174591 152 52 145 77 100 13 8 9 22 0 0.0903 1.000 1.000 260 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(2), ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), AKR1C4(4), AKR1D1(9), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH9A1(2), BAAT(6), CEL(4), CYP27A1(2), CYP7A1(4), HADHB(2), SOAT2(4), SRD5A1(2), SRD5A2(4) 3589247 130 52 122 51 86 13 8 10 13 0 0.00606 1.000 1.000 261 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(3), APOA1(1), CD36(3), CPT1B(4), CREBBP(12), EHHADH(5), EP300(7), FABP1(3), HSD17B4(3), JUN(1), LPL(2), MAPK1(2), MAPK3(1), ME1(11), MYC(2), NCOA1(5), NCOR1(12), NCOR2(14), NFKBIA(1), NR0B2(5), NR1H3(2), NR2F1(7), NRIP1(5), PDGFA(1), PIK3CA(2), PIK3R1(2), PPARA(3), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKCA(5), PTGS2(6), RB1(3), RELA(1), RXRA(1), SP1(3), STAT5A(2), STAT5B(2), TNF(1) 9749372 156 52 153 76 110 12 11 10 11 2 0.292 1.000 1.000 262 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(1), AKT2(6), AKT3(2), BCR(6), BLNK(10), BTK(6), CD19(3), CSK(1), DAG1(3), EPHB2(15), GRB2(2), ITPKB(4), LYN(1), MAP2K1(3), MAP2K2(2), MAPK1(2), NFAT5(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(1), NFKBIL1(3), PI3(5), PIK3CA(2), PIK3CD(2), PIK3R1(2), PLCG2(9), PPP1R13B(3), RAF1(2), SERPINA4(6), SOS1(4), SOS2(3), SYK(9), VAV1(12) 8116306 138 52 136 80 90 14 10 13 11 0 0.626 1.000 1.000 263 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(2), ACAD8(1), ACAD9(1), ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), AKR1B10(5), AKR1C4(4), AKR1D1(9), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2), BAAT(6), CEL(4), CYP27A1(2), CYP7A1(4), HADHB(2), RDH12(1), RDH13(3), SLC27A5(3), SOAT1(1), SOAT2(4), SRD5A1(2), SRD5A2(4) 4886218 136 51 128 65 94 11 10 8 13 0 0.0489 1.000 1.000 264 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B4GALT5(1), C1GALT1(4), C1GALT1C1(1), GALNT1(2), GALNT10(2), GALNT11(1), GALNT12(5), GALNT13(9), GALNT14(14), GALNT2(4), GALNT3(2), GALNT4(2), GALNT5(7), GALNT6(11), GALNT7(4), GALNT8(14), GALNTL1(2), GALNTL2(10), GALNTL4(1), GALNTL5(13), GCNT1(4), GCNT3(3), OGT(3), ST3GAL1(5), ST6GALNAC1(3), WBSCR17(20) 4963483 147 51 143 64 109 9 2 11 16 0 0.0507 1.000 1.000 265 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(1), DLG4(3), GRIN1(6), GRIN2A(48), GRIN2B(28), GRIN2C(6), GRIN2D(3), NOS1(32), PPP3CA(4), PPP3CB(1), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKCA(5), SYT1(11) 3904994 161 51 158 104 127 13 2 10 9 0 0.393 1.000 1.000 266 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(3), C1QB(1), C1R(8), C1S(11), C2(8), C3(21), C5(5), C6(36), C7(17), C8A(23), C9(11), MASP1(5), MASP2(7), MBL2(7) 3236178 163 50 152 72 133 7 0 10 12 1 0.0358 1.000 1.000 267 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(3), APAF1(3), ARHGDIB(1), BAG4(1), BCL2(2), BIRC2(4), BIRC3(5), CASP2(1), CASP7(3), CASP8(1), CASP9(2), CFLAR(3), CHUK(1), CRADD(1), CYCS(1), DAXX(4), DFFA(1), DFFB(2), GSN(3), LMNA(3), LMNB2(4), MAP2K7(2), MAP3K14(1), MAP3K5(9), MDM2(2), NFKB1(1), NFKBIA(1), NUMA1(5), PAK2(2), PRKCD(2), PRKDC(11), PSEN2(2), PTK2(2), RASA1(1), RB1(3), RELA(1), RIPK1(1), SPTAN1(2), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF1(4), TRAF2(1) 10641746 106 50 106 51 56 13 10 15 10 2 0.319 1.000 1.000 268 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(20), ATP4A(8), ATP5A1(1), ATP5B(1), ATP5C1(1), ATP5F1(6), ATP5H(1), ATP5O(3), ATP6V0A1(3), ATP6V0A4(11), ATP6V0D2(6), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(6), ATP6V1E2(1), ATP6V1F(1), ATP6V1G3(5), ATP6V1H(4), COX10(3), COX15(1), COX4I2(1), COX5B(1), COX7B(1), COX7B2(1), COX8A(1), CYC1(3), LHPP(1), NDUFA12(1), NDUFA13(5), NDUFA9(2), NDUFB6(2), NDUFC2(1), NDUFS2(1), NDUFS3(1), NDUFS4(1), NDUFS5(1), NDUFS6(1), NDUFS7(2), NDUFS8(1), PPA1(1), PPA2(2), SDHA(1), SDHC(2), TCIRG1(2), UQCRC1(1), UQCRFS1(1) 8619605 124 50 120 70 76 15 8 14 11 0 0.541 1.000 1.000 269 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(3), AASDHPPT(1), AASS(1), ACAT2(1), AKR1B10(5), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2), BBOX1(3), DOT1L(4), EHHADH(5), EHMT1(5), EHMT2(3), GCDH(3), HADHA(7), HSD17B10(1), HSD17B4(3), NSD1(8), OGDH(7), OGDHL(22), PIPOX(1), PLOD1(1), PLOD2(3), PLOD3(1), RDH12(1), RDH13(3), SETD1A(15), SETD7(1), SETDB1(1), SHMT2(2), TMLHE(1) 8877517 126 50 125 60 86 12 6 14 8 0 0.158 1.000 1.000 270 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(5), BCR(6), BLNK(10), FOS(1), GRB2(2), JUN(1), LYN(1), MAP2K1(3), MAPK1(2), MAPK3(1), MAPK8IP3(4), PAPPA(35), RAC1(7), RPS6KA1(2), SOS1(4), SYK(9), VAV1(12), VAV2(3), VAV3(5) 4877896 113 50 108 60 85 6 3 11 8 0 0.403 1.000 1.000 271 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT2(2), G6PC(4), GAA(3), GALK2(1), GALT(2), GANAB(4), GCK(8), GLB1(5), HK1(1), HK2(4), HK3(10), LALBA(4), LCT(24), MGAM(71), PGM1(2), PGM3(1) 4987816 148 49 142 76 111 16 2 13 6 0 0.0640 1.000 1.000 272 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(5), AGPAT2(3), AGPAT3(3), AGPAT4(4), AGPS(1), CDS1(5), CDS2(2), CHAT(10), CHKA(2), CHKB(1), CLC(2), CPT1B(4), DGKA(1), DGKB(14), DGKD(3), DGKE(5), DGKG(8), DGKH(6), DGKQ(2), DGKZ(6), GNPAT(1), GPD1(6), GPD2(1), LGALS13(1), LYPLA1(1), LYPLA2(1), PAFAH1B1(2), PAFAH2(2), PCYT1A(2), PCYT1B(2), PEMT(1), PISD(2), PLA2G2A(1), PLA2G2E(2), PLA2G3(12), PLA2G4A(7), PLA2G6(7), PLCB2(4), PLCG1(4), PLCG2(9), PPAP2B(4), PPAP2C(5) 7663026 164 49 160 89 125 10 3 14 12 0 0.159 1.000 1.000 273 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(5), B4GALT2(2), G6PC(4), G6PC2(2), GAA(3), GALK2(1), GALT(2), GANC(1), GCK(8), GLB1(5), HK1(1), HK2(4), HK3(10), LALBA(4), LCT(24), MGAM(71), PFKL(2), PGM1(2), PGM3(1), RDH12(1), RDH13(3), UGP2(1) 5911795 159 49 153 85 121 15 2 13 8 0 0.0794 1.000 1.000 274 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(3), AARS2(2), ABAT(5), ACY3(1), ADSL(6), ADSSL1(4), AGXT(8), AGXT2(10), ASL(2), ASNS(4), ASPA(2), ASRGL1(1), ASS1(2), CAD(11), CRAT(4), DARS(2), DARS2(1), DDO(2), DLAT(2), GAD1(6), GAD2(3), GOT1(4), GOT2(2), GPT(3), NARS(1), NARS2(4), PC(5), PDHA1(1), PDHA2(7), PDHB(1) 5837064 109 49 107 58 75 10 7 12 5 0 0.288 1.000 1.000 275 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(10), AGXT(8), AGXT2(10), AKR1B10(5), ALAS2(2), AMT(1), AOC2(5), AOC3(5), BHMT(6), CBS(3), CHDH(5), CHKA(2), CHKB(1), DAO(6), DMGDH(8), GAMT(2), GARS(4), GATM(1), GCAT(3), GLDC(2), GNMT(1), MAOA(2), MAOB(7), PEMT(1), PHGDH(9), PIPOX(1), PISD(2), PSAT1(1), RDH12(1), RDH13(3), SARDH(8), SARS(4), SARS2(2), SHMT2(2), TARS(1), TARS2(5) 6563936 139 49 133 75 103 7 6 10 13 0 0.161 1.000 1.000 276 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(12), ACACB(12), ACAT2(1), ACOT12(7), ACSS2(3), AKR1B1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2), DLAT(2), GLO1(1), HAGH(1), LDHA(2), LDHAL6B(5), LDHC(1), LDHD(1), MDH1(1), MDH2(1), ME1(11), ME2(1), ME3(6), PC(5), PCK1(15), PCK2(2), PDHA1(1), PDHA2(7), PDHB(1), PKLR(6), PKM2(4) 7207341 125 49 122 61 90 9 4 8 14 0 0.0840 1.000 1.000 277 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), ASCC3(4), ATP13A2(6), DDX18(1), DDX23(4), DDX4(7), DDX41(3), DDX47(1), DDX50(2), DDX51(3), DDX52(3), DDX55(2), DDX56(2), DHX58(3), ENTPD7(1), EP400(13), ERCC2(1), ERCC3(2), FPGS(3), GGH(1), IFIH1(4), MOV10L1(16), NUDT5(1), NUDT8(1), QDPR(1), RAD54B(4), RUVBL2(1), SETX(12), SKIV2L2(3), SMARCA2(8), SMARCA5(3), SPR(1) 9582668 134 49 130 69 85 10 3 19 17 0 0.455 1.000 1.000 278 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(3), AARS2(2), CARS(5), DARS(2), DARS2(1), EPRS(4), FARSA(4), FARSB(2), GARS(4), HARS(2), HARS2(2), IARS(1), IARS2(9), KARS(2), LARS(8), LARS2(3), MARS(4), MARS2(3), MTFMT(1), NARS(1), NARS2(4), QARS(6), RARS(4), RARS2(1), SARS(4), SARS2(2), TARS(1), TARS2(5), VARS(10), VARS2(4), WARS(3), WARS2(1), YARS2(1) 8432700 109 49 104 50 68 11 6 12 12 0 0.232 1.000 1.000 279 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), AKT2(6), AKT3(2), ARHGEF11(9), BCL2(2), DLG4(3), GNA13(1), LPA(24), MAP2K4(3), MAP3K5(9), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(1), NFKBIL1(3), PDK1(1), PHKA2(5), PI3(5), PIK3CB(10), PLD1(5), PLD2(2), PLD3(1), PTK2(2), ROCK1(2), ROCK2(4), SERPINA4(6), SRF(1), TBXA2R(3) 7523195 116 49 115 66 68 11 5 22 10 0 0.807 1.000 1.000 280 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(1), AKT2(6), AKT3(2), ANKRD6(2), APC(11), AXIN1(6), AXIN2(2), CER1(6), CSNK1A1(1), CTNNB1(5), DACT1(4), DKK1(1), DKK2(7), DKK3(3), DKK4(1), FSTL1(2), GSK3B(1), LRP1(14), MVP(3), NKD1(5), NKD2(4), PTPRA(2), SENP2(8), TSHB(2), WIF1(4) 6129504 103 49 103 58 62 14 2 12 13 0 0.712 1.000 1.000 281 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(3), C1QB(1), C1R(8), C1S(11), C2(8), C3(21), C5(5), C6(36), C7(17), C8A(23), C9(11) 2650657 144 48 133 64 117 6 0 10 10 1 0.0607 1.000 1.000 282 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(5), ALDOC(1), DLAT(2), ENO1(2), ENO3(1), FBP1(1), G6PC(4), GCK(8), GOT1(4), GOT2(2), GPI(2), HK1(1), HK2(4), HK3(10), LDHA(2), LDHAL6B(5), LDHC(1), MDH1(1), MDH2(1), PC(5), PCK1(15), PDHA1(1), PDHA2(7), PDHB(1), PDHX(2), PFKL(2), PGK1(1), PGK2(15), PKLR(6), PKM2(4) 6540738 117 48 112 61 93 5 5 4 10 0 0.0316 1.000 1.000 283 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(2), ADRBK2(3), ARRB2(3), CALM2(1), CALML3(3), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CLCA1(4), CLCA2(5), CLCA4(17), CNGA3(13), CNGA4(7), CNGB1(10), GNAL(2), GUCA1A(2), GUCA1B(1), GUCA1C(3), PDC(2), PDE1C(23), PRKACA(2), PRKACB(2), PRKACG(5), PRKG1(5), PRKG2(8), PRKX(1) 4621304 135 48 129 79 95 12 6 14 8 0 0.437 1.000 1.000 284 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(3), ACTG2(1), ADCY3(2), ADCY9(9), AK1(1), ARF4(1), ARF5(1), ARL4D(2), ATP6V0A1(3), ATP6V0A4(11), ATP6V0D2(6), ATP6V1A(2), ATP6V1C2(6), ATP6V1E2(1), ATP6V1F(1), ATP6V1G3(5), ATP6V1H(4), ERO1L(3), GNAS(12), PDIA4(1), PLCG1(4), PLCG2(9), PRKCA(5), SEC61A1(2), SEC61A2(3) 5709266 98 48 97 75 67 5 3 12 11 0 0.935 1.000 1.000 285 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(2), CHUK(1), DAXX(4), EGF(14), EGFR(13), ETS1(3), ETS2(7), FOS(1), HOXA7(2), IKBKB(2), JUN(1), MAP2K1(3), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP2K7(2), MAP3K14(1), MAP3K5(9), MAPK1(2), MAPK13(2), MAPK14(4), MAPK3(1), NFKB1(1), NFKBIA(1), PPP2CA(1), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCH(2), PRKCQ(12), RAF1(2), RELA(1), RIPK1(1), SP1(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(1) 7516002 131 48 130 86 91 10 5 12 13 0 0.891 1.000 1.000 286 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(3), ANXA2(1), ANXA3(3), ANXA4(1), ANXA5(1), ANXA6(3), CYP11A1(8), EDN1(6), EDNRA(3), EDNRB(3), HSD11B1(6), PLA2G4A(7), PRL(1), PTGDR(7), PTGDS(1), PTGER2(4), PTGFR(12), PTGIR(3), PTGIS(8), PTGS1(12), PTGS2(6), TBXAS1(7) 3136054 106 48 101 50 81 9 3 7 6 0 0.0282 1.000 1.000 287 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(12), ACAT2(1), AKR1B1(2), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH9A1(2), DLAT(2), GLO1(1), HAGH(1), LDHA(2), LDHC(1), LDHD(1), MDH1(1), MDH2(1), ME1(11), ME2(1), ME3(6), PC(5), PCK1(15), PDHA1(1), PDHA2(7), PDHB(1), PKLR(6), PKM2(4) 5695567 105 48 104 49 75 8 3 8 11 0 0.110 1.000 1.000 288 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(2), ACADL(2), ACADM(3), ACADSB(3), ACAT2(1), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH6A1(2), ALDH9A1(2), AOX1(13), BCAT1(6), BCKDHA(1), EHHADH(5), HADHA(7), HADHB(2), HIBADH(6), HMGCL(2), IVD(2), MCCC1(4), MCEE(1), MUT(4), OXCT1(3), PCCA(2), PCCB(1) 5559234 95 48 92 39 61 9 3 12 10 0 0.149 1.000 1.000 289 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(8), ATR(13), BRCA1(6), BRCA2(10), CHEK1(1), FANCA(2), FANCC(2), FANCD2(10), FANCE(1), FANCF(1), FANCG(3), HUS1(1), MRE11A(2), RAD1(2), RAD17(3), RAD50(3), RAD9A(4), TP53(20) 6788441 92 47 88 32 60 1 5 11 15 0 0.189 1.000 1.000 290 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(3), AGTR2(2), CALM2(1), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CDK5(3), F2(6), FYN(4), GNA11(2), GRB2(2), JAK2(6), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK14(4), MAPK3(1), MAPT(4), MYLK(17), PLCG1(4), PRKCA(5), PTK2B(7), RAF1(2), SOS1(4), STAT1(2), STAT3(6), STAT5A(2), SYT1(11) 6363040 116 47 115 77 81 9 6 10 10 0 0.844 1.000 1.000 291 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(16), AKT1(1), ITGAV(4), ITGB3(7), MAPK1(2), MAPK3(1), PDGFA(1), PDGFRA(13), PIK3CA(2), PIK3R1(2), PLCB1(29), PRKCA(5), PTK2(2), RAC1(7), SMPD1(1), SPHK1(1) 4232882 94 47 90 39 71 4 4 10 5 0 0.0642 1.000 1.000 292 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(6), CALM2(1), FCER1A(6), FCER1G(1), FOS(1), GRB2(2), JUN(1), LYN(1), MAP2K1(3), MAP2K4(3), MAP2K7(2), MAPK1(2), MAPK3(1), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), PAK2(2), PIK3CA(2), PIK3R1(2), PLA2G4A(7), PLCG1(4), PPP3CA(4), PPP3CB(1), RAF1(2), SOS1(4), SYK(9), SYT1(11), VAV1(12) 6582012 111 47 109 57 83 6 8 8 6 0 0.555 1.000 1.000 293 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(5), ACAA1(2), ACADM(3), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH6A1(2), ALDH7A1(2), ALDH9A1(2), AOX1(13), AUH(3), BCAT1(6), BCAT2(1), BCKDHA(1), DBT(1), EHHADH(5), HADHA(7), HADHB(2), HIBADH(6), HIBCH(1), HMGCL(2), HMGCS1(1), HMGCS2(11), HSD17B10(1), HSD17B4(3), IVD(2), MCCC1(4), MCEE(1), MUT(4), OXCT1(3), OXCT2(2), PCCA(2), PCCB(1) 6638559 110 47 106 43 70 11 5 15 9 0 0.0871 1.000 1.000 294 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(5), AADAC(9), ABAT(5), ACAT2(1), ACSM1(10), AKR1B10(5), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH5A1(7), ALDH7A1(2), ALDH9A1(2), BDH1(2), DDHD1(3), EHHADH(5), GAD1(6), GAD2(3), HADHA(7), HMGCL(2), HMGCS1(1), HMGCS2(11), HSD17B10(1), HSD17B4(3), ILVBL(2), L2HGDH(1), OXCT1(3), OXCT2(2), PDHA1(1), PDHA2(7), PDHB(1), PLA1A(4), PPME1(1), PRDX6(1), RDH12(1), RDH13(3) 6251509 127 47 125 62 89 10 6 10 12 0 0.126 1.000 1.000 295 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(6), F2R(3), ITGA1(14), ITGB1(3), MAP2K1(3), MAPK1(2), MAPK3(1), PLA2G4A(7), PLCB1(29), PRKCA(5), PTGS1(12), PTK2(2), RAF1(2), SYK(9), TBXAS1(7) 3738088 105 47 101 50 82 6 3 9 5 0 0.190 1.000 1.000 296 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(3), BAX(1), BCL2(2), BIRC2(4), BIRC3(5), CASP2(1), CASP7(3), CASP8(1), CASP9(2), CYCS(1), FAS(3), FASLG(10), GZMB(1), JUN(1), MAP2K4(3), MAP3K14(1), MAPK10(5), MCL1(2), MDM2(2), MYC(2), NFKB1(1), NFKBIA(1), PARP1(7), PRF1(5), RELA(1), RIPK1(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TNFSF10(5), TP53(20), TRAF1(4), TRAF2(1) 5724972 103 46 101 41 63 9 8 9 14 0 0.0667 1.000 1.000 297 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(3), AGTR1(6), ATF2(5), CALM2(1), EGFR(13), GNAQ(1), GRB2(2), JUN(1), MAP2K1(3), MAP2K2(2), MAP2K4(3), MAPK1(2), MAPK3(1), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), PAK1(2), PRKCA(5), PTK2(2), PTK2B(7), RAC1(7), RAF1(2), SOS1(4), SYT1(11) 5123981 91 46 87 52 67 6 4 8 6 0 0.703 1.000 1.000 298 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(8), ATR(13), BRCA1(6), CDC25A(5), CDC25B(1), CDC25C(3), CDC34(3), CDKN1A(1), CHEK1(1), EP300(7), MDM2(2), MYT1(12), PRKDC(11), RPS6KA1(2), TP53(20), YWHAQ(1) 6472440 96 46 93 40 62 6 6 11 11 0 0.368 1.000 1.000 299 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(10), ACY3(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH3B1(1), ALDH3B2(4), ALDH7A1(2), ALDH9A1(2), AMDHD1(2), AOC2(5), AOC3(5), ASPA(2), CARM1(2), CNDP1(7), DDC(5), FTCD(1), HAL(8), HARS(2), HARS2(2), HDC(8), HEMK1(1), LCMT1(3), MAOA(2), MAOB(7), METTL2B(5), PRMT2(1), PRMT3(3), PRMT5(3), PRMT6(1), PRMT7(1), PRMT8(7), PRPS1(1), PRPS2(1), UROC1(8) 6068989 123 46 122 84 90 13 7 5 8 0 0.693 1.000 1.000 300 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(10), ALDH1A3(2), ALDH3A1(3), ALDH3B1(1), ALDH3B2(4), AOC2(5), AOC3(5), DDC(5), EPX(4), GOT1(4), GOT2(2), HPD(2), LPO(8), MAOA(2), MAOB(7), MPO(5), MYST3(9), MYST4(11), NAT6(2), PNPLA3(1), PRDX6(1), SH3GLB1(1), TAT(10), TPO(28) 5270878 132 46 129 92 103 11 7 6 5 0 0.840 1.000 1.000 301 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(1), ARSE(2), B4GALT6(1), DEGS1(1), DEGS2(2), ENPP7(2), GAL3ST1(7), GALC(1), GBA(2), GLB1(5), LCT(24), NEU1(4), NEU2(10), NEU3(2), NEU4(5), PPAP2B(4), PPAP2C(5), SGMS1(12), SGPP2(3), SMPD1(1), SMPD3(6), SMPD4(2), SPHK1(1), SPHK2(5), SPTLC2(4), UGT8(3) 5433043 115 46 112 86 93 7 1 10 4 0 0.928 1.000 1.000 302 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(3), CAPN1(1), CAPN2(2), CXCR3(2), EGF(14), EGFR(13), ITGA1(14), ITGB1(3), MAPK1(2), MAPK3(1), MYL2(4), MYLK(17), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PTK2(2), PXN(3), TLN1(10) 4982190 104 46 101 56 80 5 4 10 5 0 0.249 1.000 1.000 303 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM2(1), CD3D(4), CD3E(2), FOS(1), FYN(4), GRB2(2), JUN(1), LCK(4), MAP2K1(3), MAP2K4(3), MAPK3(1), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), NFKB1(1), NFKBIA(1), PIK3CA(2), PIK3R1(2), PLCG1(4), PPP3CA(4), PPP3CB(1), PRKCA(5), PTPN7(1), RAC1(7), RAF1(2), RASA1(1), RELA(1), SOS1(4), SYT1(11), VAV1(12), ZAP70(4) 7313638 110 46 106 60 82 9 4 9 6 0 0.697 1.000 1.000 304 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(1), APC(11), ATF2(5), AXIN1(6), BMP10(7), BMP2(3), BMP4(1), BMP5(9), BMP7(2), BMPR1A(1), BMPR2(3), CHRD(8), CTNNB1(5), FZD1(1), GATA4(1), GSK3B(1), MEF2C(2), MYL2(4), NPPA(1), NPPB(4), RFC1(2), TGFB2(1), TGFB3(1), TGFBR2(5), TGFBR3(4), WNT1(1) 5544575 90 45 86 48 65 7 4 4 10 0 0.676 1.000 1.000 305 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(1), EIF4A1(3), EIF4A2(2), EIF4G1(6), EIF4G2(2), EIF4G3(7), GHR(14), IRS1(2), MAPK1(2), MAPK14(4), MAPK3(1), MKNK1(5), PABPC1(3), PDK2(4), PDPK1(1), PIK3CA(2), PIK3R1(2), PRKCA(5), PTEN(11), RPS6KB1(1) 4352538 78 45 78 26 41 8 5 9 15 0 0.141 1.000 1.000 306 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ACAD9(1), ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(2), MYST3(9), MYST4(11), NAT6(2), PNPLA3(1), SH3GLB1(1) 3861256 100 45 93 44 73 9 5 9 4 0 0.235 1.000 1.000 307 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(5), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2), CYP2C19(25), CYP2C9(24), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(2), EHHADH(5), HADHA(7), MYST3(9), MYST4(11), NAT6(2), PNPLA3(1), SH3GLB1(1) 4777267 114 45 109 74 83 10 4 8 9 0 0.851 1.000 1.000 308 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(3), ACTN1(2), ACTN2(14), ACTN3(5), BCAR1(3), BCR(6), CAPN1(1), CAV1(1), CSK(1), FYN(4), GRB2(2), ITGA1(14), ITGB1(3), JUN(1), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK3(1), PPP1R12B(5), PTK2(2), PXN(3), RAF1(2), RAP1A(1), ROCK1(2), SOS1(4), TLN1(10), VCL(4), ZYX(3) 7159390 104 45 102 48 68 11 4 14 6 1 0.137 1.000 1.000 309 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(4), ADRA1B(1), ADRA1D(3), ADRA2A(2), ADRA2C(2), ADRB1(3), ADRB2(1), CHRM1(4), CHRM2(7), CHRM3(10), CHRM4(4), CHRM5(1), DRD1(7), DRD2(8), DRD3(1), DRD4(1), DRD5(16), HRH1(9), HRH2(3), HTR1A(6), HTR1D(2), HTR1E(3), HTR1F(5), HTR2A(6), HTR2C(5), HTR4(4), HTR5A(10), HTR6(1), HTR7(4) 3862817 133 45 130 104 86 16 5 13 13 0 0.196 1.000 1.000 310 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(1), CDK5(3), CHN1(2), LIMK1(4), MYL2(4), MYLK(17), NCF2(4), PAK1(2), PDGFRA(13), PIK3CA(2), PIK3R1(2), PLD1(5), PPP1R12B(5), RAC1(7), RALBP1(1), RPS6KB1(1), TRIO(8), VAV1(12), WASF1(1) 5380380 94 45 88 55 67 4 4 11 8 0 0.765 1.000 1.000 311 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(2), AKT1(1), ANGPTL2(2), DAG1(3), DGKA(1), ETFA(1), GCA(2), ITGA9(9), ITPKB(4), ITPR1(16), ITPR2(10), ITPR3(4), MAP2K1(3), MAPK1(2), MAPK3(1), NR1I3(5), PAK1(2), PDE3A(13), PDE3B(3), PI3(5), PIK3C2G(20), PIK3CA(2), PIK3CD(2), PIK3R1(2), RIPK3(7) 7440573 122 45 120 52 92 11 6 5 8 0 0.0172 1.000 1.000 312 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(4), EIF2B1(5), EIF2B2(1), EIF2B3(3), EIF2B5(1), EIF2S1(1), FLT1(17), FLT4(16), KDR(22), NOS3(11), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(5), PTK2(2), PXN(3), VHL(1) 5245662 100 45 92 53 68 9 1 10 12 0 0.436 1.000 1.000 313 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(21), C5(5), C6(36), C7(17), C8A(23), C9(11) 1902674 113 44 104 49 94 3 0 6 9 1 0.100 1.000 1.000 314 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(3), BAX(1), BCL2(2), CASP1(3), CASP10(3), CASP2(1), CASP4(1), CASP7(3), CASP8(1), CASP9(2), CD40(1), CD40LG(1), CRADD(1), CYCS(1), DAXX(4), DFFA(1), DFFB(2), FAS(3), FASLG(10), IKBKE(5), LTA(2), MCL1(2), NFKB1(1), NFKBIA(1), NGFR(6), NR3C1(1), NTRK1(9), PTPN13(7), RIPK1(1), SFRS2IP(5), TFG(2), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF1(4), TRAF2(1), TRAF3(3), TRAF6(2) 6659026 100 44 100 55 69 8 5 7 11 0 0.535 1.000 1.000 315 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(10), AGXT(8), AGXT2(10), ALAS2(2), AMT(1), AOC2(5), AOC3(5), BHMT(6), CBS(3), CHDH(5), CHKA(2), CHKB(1), CPT1B(4), DAO(6), DMGDH(8), GAMT(2), GARS(4), GATM(1), GCAT(3), GLDC(2), MAOA(2), MAOB(7), PEMT(1), PISD(2), PLCB2(4), PLCG1(4), PLCG2(9), SARDH(8), SARS(4), SHMT2(2), TARS(1) 6458099 132 44 129 79 101 7 6 7 11 0 0.300 1.000 1.000 316 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(10), ALDH1A3(2), ALDH3A1(3), ALDH3B1(1), ALDH3B2(4), AOC2(5), AOC3(5), DDC(5), EPX(4), GOT1(4), GOT2(2), HPD(2), LPO(8), MAOA(2), MAOB(7), MPO(5), PRDX1(1), PRDX2(2), PRDX6(1), TAT(10), TPO(28) 3365725 111 44 109 74 89 8 6 4 4 0 0.367 1.000 1.000 317 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(5), ACACA(12), ACADL(2), ACADM(3), ACADSB(3), ACAT2(1), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH6A1(2), ALDH9A1(2), EHHADH(5), HADHA(7), LDHA(2), LDHC(1), MCEE(1), MLYCD(2), MUT(4), PCCA(2), PCCB(1) 5116436 76 44 75 35 48 7 4 12 5 0 0.405 1.000 1.000 318 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(1), ERCC3(2), GTF2A2(1), GTF2B(1), GTF2E2(4), GTF2F2(2), GTF2H1(3), GTF2H4(1), MNAT1(2), POLR1A(7), POLR1B(4), POLR2A(8), POLR2B(10), POLR2E(1), POLR2F(1), POLR2H(2), POLR3B(10), POLR3D(1), POLR3E(1), POLR3K(1), TAF6(2), TAF7(1), TAF9(1), TBP(4) 5412372 71 44 71 25 45 9 5 9 3 0 0.0714 1.000 1.000 319 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(4), EGF(14), EGFR(13), GRB2(2), MAP2K1(3), MAPK1(2), MAPK3(1), PTPRB(52), RAF1(2), RASA1(1), SOS1(4), SPRY1(6), SPRY2(3), SPRY3(6), SPRY4(1) 3830896 114 44 106 51 90 8 2 8 6 0 0.243 1.000 1.000 320 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(10), BTK(6), CALM2(1), CD79A(1), FOS(1), GRB2(2), JUN(1), LYN(1), MAP2K1(3), MAPK14(4), MAPK3(1), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), PLCG1(4), PPP3CA(4), PPP3CB(1), PRKCA(5), RAC1(7), RAF1(2), SOS1(4), SYK(9), SYT1(11), VAV1(12) 5866039 111 43 106 54 83 5 5 9 9 0 0.382 1.000 1.000 321 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(13), GNAS(12), GRB2(2), IGF1R(5), ITGB1(3), KLK2(1), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK3(1), MKNK1(5), MKNK2(2), MYC(2), NGFR(6), PDGFRA(13), PPP2CA(1), PTPRR(18), RAF1(2), RPS6KA1(2), RPS6KA5(3), SOS1(4), STAT3(6) 5039944 108 43 105 52 77 7 6 12 6 0 0.229 1.000 1.000 322 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(4), ASL(2), ASS1(2), CKM(1), CKMT1A(1), CKMT2(5), CPS1(12), DAO(6), EPRS(4), GAMT(2), GATM(1), GLUD1(1), GOT1(4), GOT2(2), NOS1(32), NOS3(11), OAT(1), OTC(2), P4HA1(6), P4HA2(4), P4HA3(7), PRODH(1), PYCR2(1), RARS(4), RARS2(1) 5492767 117 43 114 73 87 8 6 7 9 0 0.608 1.000 1.000 323 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT2(2), EXTL3(2), GLCE(6), HS2ST1(1), HS3ST1(6), HS3ST2(6), HS3ST3B1(2), HS3ST5(5), HS6ST1(1), HS6ST2(1), HS6ST3(9), NDST1(2), NDST3(13), NDST4(29) 3120031 85 43 84 37 62 5 3 6 9 0 0.0421 1.000 1.000 324 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(5), ACACA(12), ACACB(12), ACADM(3), ACAT2(1), ACSS2(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH6A1(2), ALDH7A1(2), ALDH9A1(2), EHHADH(5), HADHA(7), HIBCH(1), LDHA(2), LDHAL6B(5), LDHC(1), MCEE(1), MLYCD(2), MUT(4), PCCA(2), PCCB(1) 6131990 83 43 81 44 52 8 4 12 7 0 0.516 1.000 1.000 325 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(16), AR(7), ESR1(2), ESR2(4), ESRRA(1), HNF4A(10), NPM1(1), NR0B1(1), NR1D2(4), NR1H2(2), NR1H3(2), NR1I2(2), NR1I3(5), NR2C2(2), NR2E1(2), NR2F1(7), NR3C1(1), NR4A1(1), NR4A2(1), NR5A1(6), NR5A2(9), PGR(10), PPARA(3), PPARD(1), PPARG(6), RARB(3), RARG(1), ROR1(6), RORA(2), RORC(5), RXRA(1), RXRB(1), RXRG(1), THRA(1), THRB(10), VDR(2) 6394318 139 43 131 78 110 11 2 9 7 0 0.259 1.000 1.000 326 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(3), BLVRA(1), BLVRB(1), CP(8), CPOX(2), EPRS(4), FECH(1), GUSB(2), HCCS(1), HMBS(1), HMOX1(1), PPOX(2), UGT1A1(1), UGT1A10(10), UGT1A3(6), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(7), UGT1A8(2), UGT1A9(5), UGT2B15(16), UGT2B4(18), UROS(1) 4252460 104 43 100 50 71 8 5 7 13 0 0.221 1.000 1.000 327 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(4), AKT1(1), AKT2(6), AKT3(2), DAG1(3), GNAQ(1), ITPKB(4), ITPR1(16), ITPR2(10), ITPR3(4), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(1), NFKBIL1(3), PDK1(1), PHKA2(5), PIK3CB(10), PITX2(1), PLD1(5), PLD2(2), PLD3(1) 6875589 85 43 84 60 46 10 6 15 8 0 0.891 1.000 1.000 328 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), DAG1(3), ITPKB(4), ITPR1(16), ITPR2(10), ITPR3(4), NFAT5(3), PDE6A(9), PDE6B(11), PDE6C(16), PDE6D(2), PDE6G(2), SLC6A13(13), TF(4) 5468271 108 43 105 56 75 8 3 9 13 0 0.111 1.000 1.000 329 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(3), CHUK(1), FOS(1), IKBKB(2), JUN(1), LY96(3), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP3K14(1), MAPK14(4), MYD88(1), NFKB1(1), NFKBIA(1), PPARA(3), RELA(1), TLR10(8), TLR2(8), TLR3(6), TLR4(21), TLR6(3), TLR7(3), TLR9(7), TOLLIP(1), TRAF6(2) 5562889 91 43 90 56 63 9 3 12 4 0 0.738 1.000 1.000 330 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(6), CARM1(2), CREBBP(12), EP300(7), ERCC3(2), ESR1(2), GRIP1(3), GTF2F1(2), HDAC1(1), HDAC3(3), HDAC4(8), HDAC5(3), HDAC6(1), MEF2C(2), NCOR2(14), NR0B1(1), NRIP1(5), PELP1(8), POLR2A(8), TBP(4) 6957591 94 42 94 42 69 5 6 8 6 0 0.223 1.000 1.000 331 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(7), GNAQ(1), GNAS(12), LIMK1(4), MAP2K1(3), MAPK1(2), MAPK3(1), MYL2(4), NOX1(6), PIK3C2G(20), PLCB1(29), PPP1R12B(5), PRKCA(5), PTK2(2), RAF1(2), ROCK2(4) 3846026 107 42 102 42 80 3 2 15 7 0 0.0836 1.000 1.000 332 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(12), CALCR(11), CALCRL(8), CD97(5), CRHR1(1), CRHR2(1), ELTD1(13), EMR1(15), EMR2(1), GHRHR(4), GIPR(2), GLP1R(5), GLP2R(5), LPHN1(4), LPHN2(22), LPHN3(8), SCTR(3), VIPR1(3), VIPR2(3) 4031555 126 42 119 90 95 9 4 6 12 0 0.600 1.000 1.000 333 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(1), APC(11), AXIN1(6), CD14(3), CTNNB1(5), FZD1(1), GJA1(4), GSK3B(1), LBP(5), LEF1(1), LY96(3), MYD88(1), NFKB1(1), PDPK1(1), PIK3CA(2), PIK3R1(2), PPP2CA(1), RELA(1), TLR4(21), TOLLIP(1), WNT1(1) 4653570 73 42 71 49 48 6 4 7 8 0 0.953 1.000 1.000 334 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(10), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH3B1(1), ALDH3B2(4), ALDH9A1(2), AOC2(5), AOC3(5), ASPA(2), CNDP1(7), DDC(5), HAL(8), HARS(2), HDC(8), MAOA(2), MAOB(7), PRPS1(1), PRPS2(1) 3730129 91 42 91 60 65 10 6 5 5 0 0.590 1.000 1.000 335 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(7), ABCC2(6), ABCG2(6), BCHE(5), CES1(11), CES2(3), CYP3A4(12), CYP3A5(4), UGT1A1(1), UGT1A10(10), UGT1A3(6), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(7), UGT1A8(2), UGT1A9(5) 3526098 96 42 92 40 65 7 6 8 10 0 0.0137 1.000 1.000 336 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(4), HLA-A(1), IL18(2), ITGB1(3), KLRC1(2), KLRC2(1), KLRC3(5), KLRC4(3), KLRD1(4), MAP2K1(3), MAPK3(1), PAK1(2), PIK3CA(2), PIK3R1(2), PTK2B(7), PTPN6(1), RAC1(7), SYK(9), VAV1(12) 2849211 71 42 65 32 54 4 2 5 6 0 0.255 1.000 1.000 337 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(5), DAXX(4), DDIT3(1), GRB2(2), HMGN1(1), HSPB1(1), HSPB2(1), MAP2K4(3), MAP2K6(2), MAP3K5(9), MAP3K9(13), MAPK14(4), MAPKAPK2(2), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), MKNK1(5), MYC(2), PLA2G4A(7), RAC1(7), RIPK1(1), RPS6KA5(3), STAT1(2), TGFB2(1), TGFB3(1), TRAF2(1) 5571357 86 42 83 36 62 8 2 8 6 0 0.209 1.000 1.000 338 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(2), ESR2(4), PDE1A(21), PDE1B(6), PLCB1(29), PLCB2(4), PRL(1), TRH(3), VIP(3) 1687024 73 42 68 38 62 1 1 5 4 0 0.231 1.000 1.000 339 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(6), DLG4(3), EPHB2(15), F2(6), F2RL1(7), F2RL2(3), JUN(1), MAP2K5(2), MAPK1(2), MAPK7(2), PLD1(5), PLD2(2), PLD3(1), PTK2(2), RAF1(2), RASAL1(10), TEC(6), VAV1(12) 4203170 87 42 84 58 60 6 3 14 4 0 0.831 1.000 1.000 340 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(1), AKT2(6), AKT3(2), CISH(1), GRB2(2), IARS(1), IL13RA1(2), IL2RG(2), IL4(1), IL4R(5), INPP5D(19), JAK1(4), JAK2(6), JAK3(5), NR0B2(5), PI3(5), PIK3CA(2), PPP1R13B(3), RPS6KB1(1), SERPINA4(6), SOS1(4), SOS2(3), STAT6(2), TYK2(3) 5649932 91 42 91 48 63 8 5 8 7 0 0.568 1.000 1.000 341 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), ATF1(2), CREB5(7), DUSP10(6), EEF2K(2), HSPB1(1), IL1R1(6), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP3K10(5), MAP3K4(9), MAP3K5(9), MAPK1(2), MAPK11(1), MAPK13(2), MAPK14(4), MAPKAPK2(2), MKNK1(5), MKNK2(2), NFKB1(1), NR2C2(2), SRF(1), TRAF6(2) 5101886 81 42 81 39 56 7 3 8 7 0 0.314 1.000 1.000 342 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(1), BCL2(2), EGFR(13), IGF1R(5), MYC(2), POLR2A(8), PPP2CA(1), PRKCA(5), RB1(3), TEP1(17), TERT(4), TNKS(4), TP53(20) 4324762 85 42 83 46 48 8 5 10 12 2 0.585 1.000 1.000 343 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(29), CR2(16), FCGR2B(1), HLA-DRA(5), ICAM1(2), ITGAL(15), ITGB2(8), PTPRC(18) 2301912 94 41 87 44 75 6 0 5 8 0 0.267 1.000 1.000 344 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(5), ABAT(5), ACAT2(1), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH5A1(7), ALDH9A1(2), EHHADH(5), GAD1(6), GAD2(3), HADHA(7), HMGCL(2), L2HGDH(1), OXCT1(3), PDHA1(1), PDHA2(7), PDHB(1) 3992015 77 41 76 32 47 8 2 10 10 0 0.0769 1.000 1.000 345 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(2), ALG10B(3), ALG12(1), ALG13(3), ALG2(3), ALG3(1), ALG5(1), ALG8(2), ALG9(3), B4GALT2(2), B4GALT3(1), DDOST(1), DOLPP1(3), DPAGT1(1), DPM1(1), FUT8(4), GANAB(4), MAN1A1(8), MAN1A2(3), MAN1B1(2), MAN1C1(4), MAN2A1(6), MGAT3(8), MGAT4A(5), MGAT5(1), MGAT5B(6), RPN2(2), ST6GAL1(4), STT3B(2) 6499552 87 41 85 55 59 11 2 6 9 0 0.690 1.000 1.000 346 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(16), ARHGEF1(1), F2(6), F2R(3), GNA12(2), GNA13(1), GNAQ(1), PIK3CA(2), PIK3R1(2), PLCB1(29), PPP1R12B(5), PRKCA(5), PTK2B(7), ROCK1(2) 3966932 82 41 81 36 62 6 2 7 5 0 0.124 1.000 1.000 347 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(2), UCHL1(4), UCHL3(1), UGT1A1(1), UGT1A10(10), UGT1A3(6), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(7), UGT1A8(2), UGT1A9(5), UGT2B15(16), UGT2B4(18) 2726872 85 41 79 44 59 7 5 4 10 0 0.248 1.000 1.000 348 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(11), AXIN1(6), CREBBP(12), CTNNB1(5), EP300(7), FZD1(1), GSK3B(1), HDAC1(1), LDB1(1), LEF1(1), PITX2(1), TRRAP(21), WNT1(1) 5111888 69 41 68 43 39 6 6 8 10 0 0.939 1.000 1.000 349 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(3), CALM2(1), GNAQ(1), GRB2(2), JUN(1), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAPK1(2), MAPK14(4), MAPK3(1), PAK1(2), PLCG1(4), PRKCA(5), PTK2B(7), RAC1(7), RAF1(2), SOS1(4), SYT1(11) 4361149 69 41 65 39 50 5 3 7 4 0 0.620 1.000 1.000 350 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ARHGAP1(1), ARHGAP4(1), ARHGAP5(7), ARHGAP6(4), ARHGEF1(1), ARHGEF11(9), ARHGEF5(8), ARPC1B(1), ARPC2(1), ARPC3(1), BAIAP2(2), DIAPH1(4), GSN(3), LIMK1(4), MYL2(4), MYLK(17), OPHN1(2), PIP5K1A(6), PIP5K1B(11), PPP1R12B(5), ROCK1(2), TLN1(10), VCL(4) 6907034 110 41 108 51 78 8 5 14 5 0 0.122 1.000 1.000 351 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(3), ABAT(5), ADSL(6), AGXT(8), AGXT2(10), ASL(2), ASNS(4), ASPA(2), CAD(11), CRAT(4), DARS(2), DDO(2), GAD1(6), GAD2(3), GOT1(4), GOT2(2), GPT(3), NARS(1), PC(5) 4025494 83 40 81 44 57 9 6 8 3 0 0.217 1.000 1.000 352 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(11), CREB5(7), DAG1(3), EPHB2(15), FOS(1), GNAQ(1), ITPKB(4), JUN(1), MAP2K4(3), MAP2K7(2), MAPK1(2), MAPK10(5), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1) 4359927 67 40 67 41 45 5 3 7 7 0 0.809 1.000 1.000 353 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(16), AKT1(1), BAX(1), BCL2(2), CSF2RB(8), IGF1(6), IGF1R(5), IL3(2), IL3RA(4), KIT(7), KITLG(6), PIK3CA(2), PIK3R1(2), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3) 3358560 75 39 75 40 52 5 3 7 8 0 0.298 1.000 1.000 354 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(10), CD2(13), CD33(9), CD5(3), CSF2(2), IFNB1(4), IFNG(2), IL10(1), IL12A(2), IL12B(3), IL13(2), IL3(2), IL4(1), IL5(4), ITGAX(10), TLR2(8), TLR4(21), TLR7(3), TLR9(7) 2850547 107 39 103 56 80 10 1 6 10 0 0.0119 1.000 1.000 355 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(7), DIAPH1(4), FYN(4), GSN(3), ITGA1(14), ITGB1(3), MAP2K1(3), MAPK1(2), MAPK3(1), MYL2(4), MYLK(17), PIK3CA(2), PIK3R1(2), PTK2(2), PXN(3), RAF1(2), ROCK1(2), TLN1(10) 5737073 85 39 81 40 62 8 3 10 2 0 0.262 1.000 1.000 356 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(16), F2(6), F2R(3), FGA(19), FGB(6), FGG(3), PLAT(2), PLAU(2), PLG(14), SERPINB2(7), SERPINE1(2) 2050111 80 39 78 35 63 5 3 4 5 0 0.220 1.000 1.000 357 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(1), CABIN1(1), CALM2(1), CAMK1(4), CAMK1G(8), HDAC5(3), IGF1(6), IGF1R(5), INSR(11), MAP2K6(2), MAPK14(4), MAPK7(2), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), NFATC1(9), NFATC2(4), PIK3CA(2), PIK3R1(2), PPP3CA(4), PPP3CB(1), SYT1(11) 5357281 89 39 89 53 65 6 2 13 3 0 0.633 1.000 1.000 358 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(5), ADC(2), ALDH4A1(4), ALDH5A1(7), CAD(11), CPS1(12), EPRS(4), GAD1(6), GAD2(3), GCLC(3), GCLM(1), GFPT1(1), GFPT2(2), GLS(1), GLS2(3), GLUD1(1), GMPS(3), GOT1(4), GOT2(2), GPT(3), GSR(2), GSS(3), NADSYN1(1), QARS(6) 6073421 90 39 88 55 56 9 8 12 5 0 0.679 1.000 1.000 359 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLA2(6), POLD1(2), POLD2(1), POLD3(3), POLE(9), POLE2(1), POLG(4), POLG2(4), POLH(2), POLK(3), POLL(6), POLM(1), POLQ(12), PRIM1(1), PRIM2(8), REV1(3), REV3L(7) 6226887 74 39 74 27 42 5 5 13 9 0 0.172 1.000 1.000 360 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(18), ACE2(3), AGT(3), AGTR1(6), AGTR2(2), ANPEP(10), CMA1(3), CPA3(10), CTSA(2), CTSG(4), ENPEP(17), LNPEP(9), MAS1(1), MME(11), NLN(1), REN(7), THOP1(3) 3227518 110 39 108 62 80 12 3 5 10 0 0.253 1.000 1.000 361 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(2), GALNT10(2), GALNT2(4), GALNT3(2), GALNT4(2), GALNT6(11), GALNT7(4), GALNT8(14), GCNT1(4), ST3GAL1(5), WBSCR17(20) 2228095 70 39 68 32 53 5 1 5 6 0 0.149 1.000 1.000 362 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K4(3), MAP2K7(2), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(2), MAPK14(4), MAPK3(1), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(1), NFKBIL1(3), PIK3CA(2), PIK3CD(2), PIK3R1(2), SYT1(11), TRAF2(1), TRAF3(3), TRAF5(4), TRAF6(2) 5127456 68 39 68 50 46 6 4 9 3 0 0.866 1.000 1.000 363 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(3), CASP7(3), CASP8(1), CFLAR(3), DAXX(4), DFFA(1), DFFB(2), FAF1(3), JUN(1), LMNA(3), LMNB2(4), MAP2K4(3), PAK1(2), PAK2(2), PRKDC(11), PTPN13(7), RB1(3), RIPK2(1), SPTAN1(2) 6319986 60 38 60 29 29 7 9 12 1 2 0.554 1.000 1.000 364 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(1), GHR(14), GRB2(2), INSR(11), IRS1(2), JAK2(6), MAP2K1(3), MAPK1(2), MAPK3(1), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(5), PTPN6(1), RAF1(2), RPS6KA1(2), SLC2A4(2), SOS1(4), SRF(1), STAT5A(2), STAT5B(2) 5097085 71 38 70 41 47 6 3 11 4 0 0.652 1.000 1.000 365 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), GALNS(1), GBA(2), GLB1(5), GUSB(2), HEXA(4), HEXB(2), HGSNAT(2), HPSE(5), HPSE2(3), HYAL2(1), IDS(3), IDUA(3), LCT(24), MAN2B1(5), MAN2B2(3), MANBA(2), NAGLU(2), NEU1(4), NEU2(10), NEU3(2), NEU4(5), SPAM1(11) 5238108 102 38 102 61 77 8 2 8 7 0 0.542 1.000 1.000 366 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(3), AASDH(4), AASDHPPT(1), AASS(1), ACAT2(1), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH9A1(2), BBOX1(3), DOT1L(4), EHHADH(5), EHMT1(5), EHMT2(3), GCDH(3), HADHA(7), PLOD1(1), PLOD2(3), PLOD3(1), SHMT2(2), TMLHE(1) 5652509 71 38 70 37 45 9 2 9 6 0 0.350 1.000 1.000 367 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(1), EIF4A1(3), EIF4A2(2), EIF4B(1), EIF4G1(6), EIF4G2(2), EIF4G3(7), FKBP1A(2), MKNK1(5), PDK2(4), PDPK1(1), PIK3CA(2), PIK3R1(2), PPP2CA(1), PTEN(11), RPS6(1), RPS6KB1(1), TSC1(3), TSC2(6) 4257245 61 38 61 25 31 6 5 7 12 0 0.426 1.000 1.000 368 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(5), CCR2(6), CCR3(7), CCR4(4), CCR5(4), CCR7(2), CD4(3), CSF2(2), CXCR3(2), IFNG(2), IFNGR1(3), IFNGR2(2), IL12A(2), IL12B(3), IL12RB1(8), IL12RB2(3), IL18R1(13), IL2(4), IL4(1), IL4R(5), IL5(4), TGFB2(1), TGFB3(1) 3068840 87 38 86 46 64 8 0 6 9 0 0.0754 1.000 1.000 369 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(20), ATP5O(3), ATP6V0A1(3), ATP6V0A4(11), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(6), ATP6V1F(1), ATP6V1G3(5), ATP6V1H(4), ATP7A(1), ATP7B(12), COX10(3), COX5B(1), COX7B(1), COX8A(1), NDUFB6(2), NDUFS2(1), PPA2(2), SDHA(1), UQCRC1(1), UQCRFS1(1) 5905138 84 38 84 61 50 7 9 10 8 0 0.942 1.000 1.000 370 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(8), CDC25A(5), CDC25B(1), CDC25C(3), CDK4(2), CHEK1(1), MYT1(12), RB1(3), TP53(20) 2706098 55 38 52 22 32 1 2 7 11 2 0.372 1.000 1.000 371 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(6), EEF1B2(1), EEF2(1), EEF2K(2), EIF1AX(1), EIF2AK1(1), EIF2AK2(2), EIF2AK3(7), EIF2B1(5), EIF2B2(1), EIF2B3(3), EIF2B5(1), EIF2S1(1), EIF4A1(3), EIF4A2(2), EIF4G1(6), EIF4G3(7), ETF1(1), GSPT2(1), KIAA0664(3), PABPC1(3), PABPC3(6), PAIP1(4), SLC35A4(1) 6709074 69 38 65 33 40 4 2 10 13 0 0.631 1.000 1.000 372 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(4), AZIN1(1), BTG1(2), CLOCK(2), CRY1(3), CRY2(1), EIF4G2(2), ETV6(8), GFRA1(3), GSTM3(1), HERPUD1(1), HSPA8(2), KLF9(2), MYF6(6), NCKAP1(1), NCOA4(1), NR1D2(4), PER1(2), PER2(9), PIGF(1), PPP1R3C(2), PPP2CB(2), PURA(1), SF3A3(2), TOB1(2), TUBB3(3), UCP3(2), UGP2(1), ZFR(2) 5614615 73 37 73 42 46 6 3 11 7 0 0.912 1.000 1.000 373 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(3), CSNK1D(1), DRD1(7), DRD2(8), GRM1(7), PLCB1(29), PPP1CA(1), PPP2CA(1), PPP3CA(4), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3) 2446362 74 37 73 40 59 0 3 7 5 0 0.280 1.000 1.000 374 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(16), AKT1(1), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), GNAS(12), GRB2(2), MAPK1(2), MAPK14(4), MAPK3(1), PIK3CA(2), PIK3R1(2), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKCA(5), RAC1(7), RPS6KA1(2), RPS6KA5(3), SOS1(4) 4431883 87 37 84 47 63 5 3 9 7 0 0.577 1.000 1.000 375 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGF(14), EGFR(13), FOS(1), GRB2(2), JAK1(4), JUN(1), MAP2K1(3), MAP2K4(3), MAPK3(1), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(5), RAF1(2), RASA1(1), SOS1(4), SRF(1), STAT1(2), STAT3(6), STAT5A(2) 5740631 73 37 72 46 48 6 4 8 7 0 0.918 1.000 1.000 376 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(7), CSF1R(6), DDX20(6), E2F1(5), ETS1(3), ETS2(7), ETV3(3), FOS(1), HDAC5(3), JUN(1), NCOR2(14), RBL1(4), RBL2(2), SIN3A(2), SIN3B(7) 3993551 71 37 71 49 48 5 0 11 7 0 0.887 1.000 1.000 377 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(5), ALDH4A1(4), ALDH5A1(7), CAD(11), CPS1(12), EPRS(4), GAD1(6), GAD2(3), GCLC(3), GCLM(1), GFPT1(1), GLS(1), GLS2(3), GLUD1(1), GMPS(3), GOT1(4), GOT2(2), GPT(3), GSS(3), NADSYN1(1), QARS(6) 5106225 84 37 82 44 52 9 8 11 4 0 0.428 1.000 1.000 378 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(16), CALM2(1), FOS(1), GNAQ(1), GNAS(12), JUN(1), MAP2K1(3), MAPK3(1), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), PLCG1(4), PPP3CA(4), PPP3CB(1), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKCA(5), RAF1(2), SYT1(11) 5328890 97 37 96 59 74 7 4 6 6 0 0.733 1.000 1.000 379 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(13), PGAP1(2), PIGB(2), PIGC(1), PIGF(1), PIGG(9), PIGK(3), PIGL(2), PIGN(2), PIGO(6), PIGQ(5), PIGS(1), PIGT(1), PIGU(2), PIGV(4), PIGW(1), PIGX(1), PIGZ(1) 3680966 57 37 57 30 39 3 3 8 4 0 0.315 1.000 1.000 380 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(5), ALDOC(1), FBP1(1), GOT1(4), GOT2(2), GPT(3), MDH1(1), MDH2(1), ME1(11), ME3(6), PGK1(1), PGK2(15), PKLR(6), PKM2(4), TKT(5), TKTL1(1), TKTL2(14) 3119021 82 37 80 48 65 5 3 3 6 0 0.163 1.000 1.000 381 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(1), IFNB1(4), IKBKB(2), IL1A(2), IL1B(2), IL1R1(6), IL1RAP(2), IL1RN(5), IRAK2(8), IRAK3(5), JUN(1), MAP2K3(4), MAP2K6(2), MAP3K14(1), MAPK14(4), MYD88(1), NFKB1(1), NFKBIA(1), RELA(1), TGFB2(1), TGFB3(1), TNF(1), TOLLIP(1), TRAF6(2) 4525375 59 37 58 37 37 6 1 7 8 0 0.765 1.000 1.000 382 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(1), BCL2(2), CBL(4), CFLAR(3), E2F1(5), FOS(1), GRB2(2), IL2RA(4), IL2RB(6), IL2RG(2), IRS1(2), JAK1(4), JAK3(5), MAPK1(2), MAPK3(1), MYC(2), PIK3CA(2), PIK3R1(2), PPIA(1), PTPN6(1), RAF1(2), RPS6KB1(1), SOCS3(2), SOS1(4), STAT5A(2), STAT5B(2), SYK(9) 5523607 74 37 73 42 49 5 8 7 5 0 0.674 1.000 1.000 383 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(3), DAB1(26), FYN(4), LRP8(3), RELN(42), VLDLR(2) 2145157 80 37 77 37 61 4 2 7 6 0 0.461 1.000 1.000 384 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(3), ACTN1(2), ACTN2(14), ACTN3(5), CAPN1(1), ITGA1(14), ITGB1(3), ITGB3(7), PTK2(2), PXN(3), RAC1(7), SPTAN1(2), TLN1(10) 4324607 73 37 69 36 52 5 3 8 4 1 0.0993 1.000 1.000 385 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(16), CD3D(4), CD3E(2), CD4(3), CREBBP(12), CSK(1), GNAS(12), HLA-DRA(5), LCK(4), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PTPRC(18), ZAP70(4) 3473389 94 36 91 52 71 6 3 7 7 0 0.449 1.000 1.000 386 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(16), CD3D(4), CD3E(2), CD4(3), CREBBP(12), CSK(1), GNAS(12), HLA-DRA(5), LCK(4), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PTPRC(18), ZAP70(4) 3473389 94 36 91 52 71 6 3 7 7 0 0.449 1.000 1.000 387 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(2), CDT1(1), DIAPH2(2), MCM10(5), MCM2(7), MCM3(5), MCM4(2), MCM5(2), MCM6(2), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(1), ORC5L(1), ORC6L(2), PCNA(1), POLA2(6), POLD1(2), POLD2(1), POLD3(3), POLE(9), POLE2(1), PRIM1(1), RFC1(2), RFC3(1), RPA1(1), RPA4(2), UBC(3) 7788386 70 36 70 38 47 4 2 7 10 0 0.489 1.000 1.000 388 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(2), F2(6), F2R(3), F5(19), F7(2), FGA(19), FGB(6), FGG(3), PROC(7), PROS1(8), SERPINC1(5), TFPI(5) 2520474 85 36 82 38 63 7 4 5 6 0 0.278 1.000 1.000 389 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSD(1), ARSE(2), GAL3ST1(7), GALC(1), GBA(2), GLB1(5), LCT(24), NEU1(4), NEU2(10), NEU3(2), NEU4(5), PPAP2B(4), PPAP2C(5), SMPD1(1), SPTLC2(4) 3674244 77 36 75 58 62 6 1 5 3 0 0.922 1.000 1.000 390 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(5), ALDOA(1), ALDOB(5), ALDOC(1), FBP1(1), FPGT(2), FUK(1), GMDS(2), GMPPA(1), GMPPB(1), HK1(1), HK2(4), HK3(10), KHK(1), LHPP(1), MPI(1), MTMR1(2), MTMR2(1), MTMR6(2), PFKFB1(1), PFKFB2(3), PFKFB3(2), PFKFB4(4), PFKL(2), PGM2(5), RDH12(1), RDH13(3), SORD(1), TSTA3(2) 5662822 69 36 68 46 50 8 3 3 5 0 0.452 1.000 1.000 391 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(10), ADC(2), AGMAT(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2), AOC2(5), AOC3(5), ASL(2), ASS1(2), CPS1(12), GATM(1), MAOA(2), MAOB(7), ODC1(2), OTC(2), SMS(1) 4472283 69 36 69 49 47 8 6 2 6 0 0.750 1.000 1.000 392 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT2(3), AGPAT3(3), AGPAT4(4), AGPS(1), CHPT1(1), ENPP6(8), PAFAH1B1(2), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(2), PLA2G12B(3), PLA2G2A(1), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(12), PLA2G4A(7), PLA2G6(7), PLD1(5), PLD2(2), PPAP2B(4), PPAP2C(5) 3588448 82 36 80 45 59 6 2 7 8 0 0.490 1.000 1.000 393 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(9), ABP1(10), AOC2(5), AOC3(5), CES1(11), CES7(7), DDHD1(3), MYST3(9), MYST4(11), NAT6(2), PLA1A(4), PNPLA3(1), PPME1(1), PRDX6(1), SH3GLB1(1) 3908609 80 36 79 39 63 4 6 2 5 0 0.398 1.000 1.000 394 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(22), AKT1(1), ATM(8), BAX(1), CDKN1A(1), CSNK1A1(1), CSNK1D(1), HIC1(1), IGFBP3(1), MDM2(2), NFKBIB(1), NQO1(1), TP53(20) 3197930 61 36 55 28 36 6 1 6 12 0 0.522 1.000 1.000 395 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(11), AXIN1(6), BTRC(3), CREBBP(12), CSNK1A1(1), CSNK1D(1), CTNNB1(5), FZD1(1), GSK3B(1), HDAC1(1), MYC(2), NLK(2), PPARD(1), PPP2CA(1), TLE1(2), WIF1(4), WNT1(1) 4478075 55 36 55 33 29 4 5 5 12 0 0.928 1.000 1.000 396 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(4), AKR1D1(9), CYP11A1(8), CYP11B1(7), CYP11B2(8), CYP17A1(4), CYP21A2(10), HSD11B1(6), HSD3B1(1), HSD3B2(9) 1510325 66 35 63 38 45 5 2 7 7 0 0.135 1.000 1.000 397 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(3), CRK(2), CXCL12(1), GNAQ(1), MAP2K1(3), MAPK1(2), MAPK3(1), NFKB1(1), PIK3C2G(20), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(5), PTK2(2), PTK2B(7), PXN(3), RAF1(2), RELA(1) 4217182 62 35 60 37 47 3 0 6 6 0 0.704 1.000 1.000 398 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(3), BCL2(2), BIRC2(4), BIRC3(5), CASP10(3), CASP7(3), CASP8(1), CASP9(2), CFLAR(3), CHUK(1), CYCS(1), DFFA(1), DFFB(2), GAS2(4), LMNA(3), MAP3K14(1), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(1), SPTAN1(2), TNFRSF10A(3), TNFRSF10B(1), TNFRSF25(3), TNFSF10(5), TRAF2(1) 5145053 58 35 58 41 38 6 7 6 1 0 0.887 1.000 1.000 399 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(4), AKR1D1(9), CYP11A1(8), CYP11B1(7), CYP11B2(8), CYP17A1(4), CYP21A2(10), HSD11B1(6), HSD3B1(1), HSD3B2(9) 1510325 66 35 63 38 45 5 2 7 7 0 0.135 1.000 1.000 400 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1L(3), GTF2A2(1), GTF2B(1), GTF2E2(4), GTF2F1(2), GTF2F2(2), GTF2H1(3), GTF2H3(1), GTF2H4(1), GTF2I(2), GTF2IRD1(4), TAF1(5), TAF1L(27), TAF2(2), TAF4(4), TAF5L(2), TAF6(2), TAF6L(2), TAF7(1), TAF7L(3), TAF9(1), TBPL2(1) 5583368 74 35 73 33 48 9 3 10 4 0 0.466 1.000 1.000 401 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(1), EIF2B5(1), EIF2S1(1), GSK3B(1), IGF1(6), IGF1R(5), INPPL1(9), PDK2(4), PDPK1(1), PIK3CA(2), PIK3R1(2), PPP2CA(1), PTEN(11), RPS6(1), RPS6KB1(1) 3019164 47 35 47 21 23 3 6 6 9 0 0.533 1.000 1.000 402 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(7), ARHGEF1(1), GNA12(2), GNA13(1), GNAQ(1), MYL2(4), MYLK(17), PLCB1(29), PPP1R12B(5), PRKCA(5), ROCK1(2) 3200411 74 35 71 31 59 3 2 6 4 0 0.141 1.000 1.000 403 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(1), PIK3CA(2), PIK3R1(2), PLCB1(29), PLCG1(4), PRKCA(5), VAV1(12) 1977653 55 35 54 26 46 2 0 4 3 0 0.312 1.000 1.000 404 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(4), GBA3(5), LPO(8), MPO(5), PRDX1(1), PRDX2(2), PRDX6(1), TPO(28), TYR(2) 1488167 56 35 54 31 44 4 1 2 5 0 0.293 1.000 1.000 405 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(3), ATM(8), BRCA1(6), CDKN1A(1), CHEK1(1), JUN(1), MDM2(2), MRE11A(2), NFKB1(1), NFKBIA(1), RAD50(3), RBBP8(2), RELA(1), TP53(20), TP73(4) 4561288 56 34 53 23 33 4 3 6 10 0 0.469 1.000 1.000 406 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(6), AGT(3), AGTR2(2), EDN1(6), EDNRA(3), EDNRB(3), EGF(14), EGFR(13), FOS(1), JUN(1), MYC(2), NFKB1(1), PLCG1(4), PRKCA(5), RELA(1) 3157363 65 34 64 43 49 4 2 6 4 0 0.763 1.000 1.000 407 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(14), EGFR(13), MAP2K1(3), MAPK14(4), NCOR2(14), RXRA(1), THRA(1), THRB(10) 2629409 60 34 59 34 44 5 1 7 3 0 0.614 1.000 1.000 408 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(5), ALDOC(1), DERA(1), FBP1(1), G6PD(2), GPI(2), H6PD(3), PFKL(2), PGD(2), PGLS(1), PGM1(2), PGM3(1), PRPS1(1), PRPS1L1(7), PRPS2(1), RBKS(3), TALDO1(3), TKT(5), TKTL1(1), TKTL2(14) 3726322 59 34 59 49 39 7 1 4 8 0 0.873 1.000 1.000 409 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(2), CREBBP(12), EP300(7), FYN(4), IL2RG(2), IL7(3), IL7R(15), JAK1(4), JAK3(5), LCK(4), PIK3CA(2), PIK3R1(2), PTK2B(7), STAT5A(2), STAT5B(2) 4284911 73 34 72 37 51 9 2 6 5 0 0.482 1.000 1.000 410 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(22), ABCB11(27), ABCB4(8), ABCC1(7), ABCC3(17) 2182141 81 34 77 40 57 5 1 5 13 0 0.0177 1.000 1.000 411 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(2), GTF2B(1), GTF2F1(2), HDAC3(3), NCOA1(5), NCOA2(10), NCOA3(7), NCOR2(14), POLR2A(8), RXRA(1), TBP(4) 3815883 57 34 56 27 44 3 3 4 3 0 0.354 1.000 1.000 412 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(4), DYRK1B(2), GLI2(20), GLI3(7), GSK3B(1), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), SHH(2), SMO(4), SUFU(1) 2544617 54 34 52 29 40 6 2 3 3 0 0.327 1.000 1.000 413 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(2), CNR1(7), CNR2(1), DNMT1(10), MTNR1A(6), MTNR1B(5), PTGDR(7), PTGER2(4), PTGFR(12), PTGIR(3), TBXA2R(3) 1712311 60 34 56 41 42 5 3 3 7 0 0.244 1.000 1.000 414 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(4), CSF1R(6), EGF(14), EGFR(13), GRB2(2), MET(7), PDGFRA(13), PRKCA(5), SH3GLB1(1), SH3KBP1(2) 2997125 67 33 67 48 46 3 3 7 8 0 0.954 1.000 1.000 415 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(5), ACO1(1), ACO2(1), CLYBL(1), CS(1), FH(3), IDH1(6), IDH3A(2), IDH3G(2), MDH1(1), MDH2(1), OGDH(7), OGDHL(22), PC(5), PCK1(15), PCK2(2), SDHA(1), SDHC(2) 4619220 78 33 74 41 59 3 4 6 6 0 0.242 1.000 1.000 416 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(13), CD38(3), ENPP1(7), ENPP3(8), NADK(2), NADSYN1(1), NMNAT2(2), NMNAT3(3), NNMT(7), NNT(3), NT5C1B(16), NT5C3(2), NT5E(3), NT5M(1), NUDT12(1), QPRT(4) 3315222 76 33 73 47 50 9 4 7 6 0 0.813 1.000 1.000 417 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(2), BAIAP2(2), CASP1(3), CASP7(3), CASP8(1), INSR(11), ITCH(2), MAGI1(16), MAGI2(14), RERE(11), WWP1(1), WWP2(3) 3705842 69 33 69 34 48 4 3 11 3 0 0.577 1.000 1.000 418 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(4), CD3D(4), CD3E(2), CXCR3(2), ETV5(4), IFNG(2), IL12A(2), IL12B(3), IL12RB1(8), IL12RB2(3), IL18(2), IL18R1(13), JAK2(6), JUN(1), MAP2K6(2), MAPK14(4), STAT4(12), TYK2(3) 2851714 77 33 77 35 60 5 2 7 3 0 0.224 1.000 1.000 419 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 CAT(3), EPX(4), LPO(8), MPO(5), PRDX1(1), PRDX2(2), PRDX6(1), SHMT2(2), TPO(28) 1823422 54 33 52 29 43 4 1 3 3 0 0.169 1.000 1.000 420 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(3), ADCY1(16), CDC25C(3), GNAS(12), MAPK1(2), MAPK3(1), MYT1(12), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), RPS6KA1(2) 3146067 64 33 64 42 52 2 2 4 4 0 0.603 1.000 1.000 421 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(1), CREBBP(12), EP300(7), IKBKB(2), IL1B(2), IL8(1), MAP2K3(4), MAP2K6(2), MAP3K14(1), MAPK11(1), MAPK14(4), MYD88(1), NFKB1(1), NFKBIA(1), NR3C1(1), RELA(1), TGFBR2(5), TLR2(8), TNF(1) 4568895 56 33 56 36 36 9 2 5 4 0 0.887 1.000 1.000 422 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM2(1), CAMK1(4), CAMK1G(8), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CAMK4(8), ESRRA(1), HDAC5(3), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), PPARA(3), PPP3CA(4), PPP3CB(1), SLC2A4(2), SYT1(11) 3078826 65 33 65 38 51 4 2 6 2 0 0.485 1.000 1.000 423 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(1), AKT2(6), AKT3(2), GRB2(2), MAPK1(2), MAPK3(1), PDK1(1), PIK3CA(2), PIK3CD(2), PTEN(11), PTK2B(7), RBL2(2), SOS1(4) 3154289 43 33 43 18 22 3 2 8 8 0 0.544 1.000 1.000 424 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(3), CARS(5), DARS(2), EPRS(4), GARS(4), HARS(2), IARS(1), KARS(2), LARS(8), LARS2(3), MARS(4), MARS2(3), NARS(1), QARS(6), RARS(4), SARS(4), TARS(1), WARS(3), WARS2(1) 4968601 61 32 60 20 38 5 4 7 7 0 0.0476 1.000 1.000 425 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(2), ACTN2(14), ACTN3(5), BCAR1(3), CSK(1), CTNNA1(2), CTNNA2(14), CTNNB1(5), PTK2(2), PXN(3), VCL(4) 2893298 55 32 55 34 36 1 1 10 6 1 0.598 1.000 1.000 426 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(16), ADRB2(1), CFTR(24), GNAS(12), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), SLC9A3R1(1) 1983658 67 32 64 40 51 3 3 6 4 0 0.548 1.000 1.000 427 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(2), ALOX15(4), ALOX15B(5), ALOX5(6), ALOX5AP(1), DPEP1(3), GGT1(3), LTA4H(2), PLA2G2A(1), PLA2G6(7), PTGDS(1), PTGIS(8), PTGS1(12), PTGS2(6), TBXAS1(7) 2290392 68 32 67 41 48 4 2 9 5 0 0.269 1.000 1.000 428 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(6), GABRA1(7), GABRA2(8), GABRA3(12), GABRA4(6), GABRA5(2), GABRA6(15), UBQLN1(3) 1797768 59 32 56 34 50 3 0 1 5 0 0.485 1.000 1.000 429 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(8), CYP2A13(4), CYP2A6(7), CYP2A7(5), NAT2(5), XDH(33) 1237848 62 32 61 39 52 0 5 2 3 0 0.157 1.000 1.000 430 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(6), ANAPC2(1), ANAPC5(3), ANAPC7(4), BTRC(3), CDC16(1), CDC27(5), CUL1(2), CUL2(2), CUL3(2), FBXW11(4), FBXW7(7), FZR1(1), ITCH(2), SMURF1(1), SMURF2(3), TCEB1(1), UBA1(2), UBE2D3(2), UBE2E2(2), VHL(1), WWP1(1), WWP2(3) 6126334 59 32 58 29 37 2 4 10 6 0 0.739 1.000 1.000 431 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(1), CS(1), DLAT(2), FH(3), IDH3A(2), IDH3G(2), MDH1(1), MDH2(1), OGDH(7), PC(5), PDHA1(1), PDHA2(7), PDHB(1), PDHX(2), PDK1(1), PDK2(4), PDK3(3), PDK4(5), PDP2(4), SDHA(1), SDHC(2) 4381761 56 32 56 25 38 2 4 5 7 0 0.227 1.000 1.000 432 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(16), ADRB2(1), GNAS(12), PLCE1(22), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3) 2238489 64 32 64 33 49 3 4 5 3 0 0.321 1.000 1.000 433 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(1), CASP2(1), CASP8(1), CRADD(1), DFFA(1), DFFB(2), JUN(1), LMNA(3), LMNB2(4), MADD(7), MAP2K4(3), PAK1(2), PAK2(2), PRKDC(11), RB1(3), RIPK1(1), SPTAN1(2), TNF(1), TNFRSF1A(2), TRAF2(1) 6000007 51 32 50 21 26 7 6 7 3 2 0.190 1.000 1.000 434 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(18), AGT(3), AGTR1(6), AGTR2(2), BDKRB2(2), KNG1(3), NOS3(11), REN(7) 1517668 52 31 50 39 36 4 1 4 7 0 0.639 1.000 1.000 435 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(5), CHAT(10), COMT(1), DBH(5), DDC(5), GAD1(6), GAD2(3), HDC(8), MAOA(2), PAH(3), PNMT(3), SLC18A3(2), TH(6), TPH1(1) 2172137 61 31 61 50 47 5 2 2 5 0 0.840 1.000 1.000 436 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(16), GNAS(12), PPP2CA(1), PRKAA1(1), PRKAA2(15), PRKAB2(1), PRKACB(2), PRKACG(5), PRKAG1(1), PRKAG2(2), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3) 2343498 62 31 61 31 50 2 3 3 4 0 0.332 1.000 1.000 437 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(3), EPHA4(9), EPHB1(13), FYN(4), ITGA1(14), ITGB1(3), L1CAM(3), LYN(1), SELP(13) 2423888 63 31 59 34 48 4 1 6 4 0 0.452 1.000 1.000 438 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(10), G6PD(2), GCLC(3), GCLM(1), GGT1(3), GPX1(2), GPX3(2), GPX5(6), GPX6(5), GSR(2), GSS(3), GSTA1(5), GSTA3(1), GSTA5(1), GSTK1(1), GSTM1(1), GSTM3(1), GSTM4(1), GSTM5(2), IDH1(6), MGST1(1), MGST2(1), OPLAH(8) 3352867 68 31 64 34 45 5 2 12 4 0 0.155 1.000 1.000 439 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 GALNS(1), GLB1(5), GUSB(2), HEXA(4), HEXB(2), HGSNAT(2), HPSE(5), HPSE2(3), HYAL2(1), IDS(3), IDUA(3), LCT(24), NAGLU(2), SPAM1(11) 3119654 68 31 68 41 49 5 1 6 7 0 0.602 1.000 1.000 440 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(4), GBA(2), GBA3(5), LPO(8), MPO(5), PRDX6(1), TPO(28) 1291939 53 31 51 31 43 4 1 2 3 0 0.271 1.000 1.000 441 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(7), POLR1B(4), POLR1C(1), POLR2A(8), POLR2B(10), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2L(1), POLR3A(2), POLR3B(10), POLR3GL(1), POLR3K(1) 3616531 50 31 50 20 29 8 3 6 4 0 0.192 1.000 1.000 442 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 FOS(1), GRB2(2), JAK1(4), JUN(1), MAP2K1(3), MAP2K4(3), MAPK3(1), PDGFA(1), PDGFRA(13), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(5), RAF1(2), RASA1(1), SOS1(4), SRF(1), STAT1(2), STAT3(6), STAT5A(2) 5344606 60 31 59 36 38 5 4 7 6 0 0.831 1.000 1.000 443 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(11), CDH1(4), CREBBP(12), EP300(7), MAP2K1(3), MAPK3(1), SKIL(1), TGFB2(1), TGFB3(1), TGFBR2(5) 3952713 46 31 45 21 29 5 1 3 8 0 0.694 1.000 1.000 444 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(12), HLA-DRA(5), IFNG(2), IFNGR1(3), IFNGR2(2), IL12A(2), IL12B(3), IL12RB1(8), IL12RB2(3), IL18(2), IL18R1(13), IL2(4), IL2RA(4), IL4(1), IL4R(5) 1948541 69 31 68 27 53 5 0 3 8 0 0.0627 1.000 1.000 445 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM2(1), CHUK(1), EGR2(3), EGR3(1), GNAQ(1), MYC(2), NFATC1(9), NFATC2(4), NFKB1(1), NFKBIA(1), PLCG1(4), PPP3CA(4), PPP3CB(1), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), RELA(1), SYT1(11), VIP(3), VIPR2(3) 4277774 64 31 64 48 50 4 4 4 2 0 0.944 1.000 1.000 446 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), GLB1(5), HEXA(4), HEXB(2), LCT(24), MAN2B1(5), MAN2B2(3), MANBA(2), NEU1(4), NEU2(10), NEU3(2), NEU4(5) 3117846 67 30 67 40 53 6 1 6 1 0 0.540 1.000 1.000 447 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 CAT(3), EPX(4), LPO(8), MPO(5), MTHFR(1), PRDX6(1), SHMT2(2), TPO(28) 1801603 52 30 50 31 42 4 1 3 2 0 0.283 1.000 1.000 448 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(2), ACOX1(3), ACOX3(5), ELOVL2(2), ELOVL6(2), FADS2(2), FASN(9), HADHA(7), SCD(2) 2198991 34 30 34 20 22 4 0 4 4 0 0.362 1.000 1.000 449 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 FOS(1), GRB2(2), IL2(4), IL2RA(4), IL2RB(6), IL2RG(2), JAK1(4), JAK3(5), JUN(1), LCK(4), MAP2K1(3), MAPK3(1), RAF1(2), SOS1(4), STAT5A(2), STAT5B(2), SYK(9) 3526803 56 30 54 30 40 3 3 5 5 0 0.472 1.000 1.000 450 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(8), ATR(13), CDC25C(3), CHEK1(1), TP53(20) 2459521 45 30 42 17 26 1 3 5 10 0 0.491 1.000 1.000 451 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(13), CD3D(4), CD3E(2), CD4(3), ICAM1(2), ITGAL(15), ITGB2(8), PTPRC(18) 1706421 65 30 60 35 51 3 0 4 7 0 0.199 1.000 1.000 452 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(7), GABRA2(8), GABRA3(12), GABRA4(6), GABRA5(2), GABRA6(15), GPX1(2), PRKCE(3) 1181592 55 29 52 28 43 5 0 3 4 0 0.281 1.000 1.000 453 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(1), BCL2(2), BCR(6), FOS(1), GRB2(2), JAK2(6), JUN(1), MAP2K1(3), MAP2K4(3), MAPK3(1), MYC(2), PIK3CA(2), PIK3R1(2), RAF1(2), SOS1(4), STAT1(2), STAT5A(2), STAT5B(2) 4289561 44 29 43 25 26 6 4 6 2 0 0.745 1.000 1.000 454 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(4), ASRGL1(1), CA1(6), CA12(3), CA13(4), CA2(4), CA3(3), CA4(1), CA5A(1), CA5B(1), CA6(2), CA8(3), CA9(3), CPS1(12), GLS(1), GLS2(3), GLUD1(1), HAL(8) 3234425 62 29 62 28 50 4 2 4 2 0 0.199 1.000 1.000 455 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG5(1), ATG7(4), GABARAPL1(1), IFNA10(1), IFNA14(4), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(6), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(2), IFNG(2), PIK3R4(2), PRKAA1(1), PRKAA2(15), ULK1(4), ULK2(4), ULK3(1) 3216335 62 29 60 33 49 2 4 5 2 0 0.373 1.000 1.000 456 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(4), CA1(6), CA12(3), CA2(4), CA3(3), CA4(1), CA5A(1), CA5B(1), CA6(2), CA8(3), CA9(3), CPS1(12), GLS(1), GLS2(3), GLUD1(1), HAL(8) 2890438 57 29 57 26 45 4 2 4 2 0 0.229 1.000 1.000 457 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(3), ATP6V0A1(3), ATP6V0A4(11), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(6), ATP6V1F(1), ATP6V1G3(5), ATP6V1H(4), FDXR(6) 2467243 43 29 43 29 23 3 2 8 7 0 0.770 1.000 1.000 458 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(1), BCAR1(3), GRB2(2), ITGB1(3), MAPK1(2), MAPK3(1), PDK2(4), PDPK1(1), PIK3CA(2), PIK3R1(2), PTEN(11), PTK2(2), SOS1(4) 2937729 38 29 38 17 18 2 2 8 8 0 0.765 1.000 1.000 459 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(1), AKT2(6), AKT3(2), BCL2(2), GRB2(2), GSK3B(1), IL4R(5), IRS1(2), JAK1(4), JAK3(5), MAP4K1(3), MAPK1(2), MAPK3(1), PDK1(1), PIK3CA(2), PIK3CD(2), PIK3R1(2), PPP1R13B(3), RAF1(2), SOS1(4), SOS2(3), STAT6(2) 5600829 57 29 57 32 37 10 2 5 3 0 0.655 1.000 1.000 460 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(4), BIRC3(5), CASP8(1), CFLAR(3), JUN(1), MAP2K4(3), MAP3K3(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(1), NFKBIL1(3), NR2C2(2), RALBP1(1), RIPK1(1), TNF(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(1) 4158233 40 29 40 23 18 5 6 9 2 0 0.697 1.000 1.000 461 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(3), ACTR2(2), ARPC1B(1), ARPC2(1), ARPC3(1), NCKAP1(1), NTRK1(9), RAC1(7), WASF1(1), WASF2(4), WASF3(9), WASL(1) 2351805 40 28 36 15 32 1 2 2 3 0 0.246 1.000 1.000 462 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(3), ATP6V0A1(3), ATP6V0A4(11), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(6), ATP6V1F(1), ATP6V1G3(5), ATP6V1H(4) 2319392 37 28 37 26 19 3 2 7 6 0 0.822 1.000 1.000 463 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(5), ALDOC(1), FBP1(1), GOT1(4), GOT2(2), GPT(3), MDH1(1), MDH2(1), ME1(11), ME2(1), ME3(6), PGK1(1), PKLR(6), PKM2(4), TKT(5) 2785026 53 28 53 28 39 3 3 3 5 0 0.163 1.000 1.000 464 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(3), ATP6V0A1(3), ATP6V0A4(11), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(6), ATP6V1F(1), ATP6V1G3(5), ATP6V1H(4) 2319392 37 28 37 26 19 3 2 7 6 0 0.822 1.000 1.000 465 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(1), AKT1(1), ANXA1(3), CALM2(1), GNAS(12), NFKB1(1), NOS3(11), NPPA(1), NR3C1(1), PIK3CA(2), PIK3R1(2), RELA(1), SYT1(11) 2724358 48 28 47 31 40 2 2 3 1 0 0.829 1.000 1.000 466 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(10), G6PD(2), GCLC(3), GCLM(1), GGT1(3), GPX1(2), GPX3(2), GPX5(6), GSS(3), GSTA1(5), GSTA3(1), GSTM1(1), GSTM3(1), GSTM4(1), GSTM5(2), IDH1(6), MGST1(1), MGST2(1), PGD(2) 2776425 53 28 49 26 34 4 2 10 3 0 0.209 1.000 1.000 467 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CHIA(7), CHIT1(4), CTBS(2), GFPT1(1), GFPT2(2), GNE(2), HEXA(4), HEXB(2), HK1(1), HK2(4), HK3(10), LHPP(1), MTMR1(2), MTMR2(1), MTMR6(2), PGM3(1), UAP1(1) 4401449 48 28 47 29 31 4 3 5 5 0 0.662 1.000 1.000 468 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(12), CPT1A(6), LEP(1), LEPR(10), PRKAA1(1), PRKAA2(15), PRKAB2(1), PRKAG1(1), PRKAG2(2) 2250249 49 28 47 31 40 2 1 2 4 0 0.843 1.000 1.000 469 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(1), IKBKB(2), IL1A(2), IL1R1(6), MAP3K14(1), MYD88(1), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(1), TLR4(21), TNF(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(1), TRAF6(2) 3675056 45 28 44 31 32 2 2 4 5 0 0.861 1.000 1.000 470 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(4), CD2(13), CD3D(4), CD3E(2), CD4(3), CXCR3(2), IFNG(2), IL12A(2), IL12B(3), IL12RB1(8), IL12RB2(3), JAK2(6), STAT4(12), TYK2(3) 2232733 67 28 65 39 50 6 2 6 3 0 0.515 1.000 1.000 471 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(5), ALDOC(1), FBP1(1), G6PD(2), GPI(2), H6PD(3), PGD(2), PGLS(1), PGM1(2), PGM3(1), PRPS1(1), PRPS1L1(7), PRPS2(1), RBKS(3), TAL1(4), TALDO1(3), TKT(5) 3139877 45 28 45 40 28 5 1 5 6 0 0.939 1.000 1.000 472 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(18), CD44(4), CSF1(7), FCGR3A(3), IL1B(2), IL6R(2), SELL(5), SPN(3), TGFB2(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF8(9), TNFSF8(2) 1983619 60 28 59 26 47 4 2 1 6 0 0.0614 1.000 1.000 473 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6R(2), JAK1(4), JAK2(6), JAK3(5), PIAS3(3), PTPRU(11), REG1A(4), STAT3(6) 2330641 42 28 42 20 26 4 2 5 5 0 0.242 1.000 1.000 474 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(5), APOA1(1), APOA4(4), APOC1(1), CETP(2), CYP7A1(4), HMGCR(7), LDLR(9), LIPC(5), LPL(2), LRP1(14), SCARB1(3), SOAT1(1) 4264809 58 28 57 37 39 4 3 6 6 0 0.573 1.000 1.000 475 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(2), CASP2(1), CHUK(1), CRADD(1), IKBKB(2), JUN(1), LTA(2), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP3K14(1), MAP4K2(4), MAPK14(4), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(1), TNF(1), TNFRSF1A(2), TRAF2(1) 3650855 36 28 36 28 22 5 2 3 4 0 0.925 1.000 1.000 476 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(3), ATP6V0A1(3), ATP6V0A4(11), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(6), ATP6V1F(1), ATP6V1G3(5), ATP6V1H(4) 2319392 37 28 37 26 19 3 2 7 6 0 0.822 1.000 1.000 477 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(2), CREBBP(12), EP300(7), NCOA3(7), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), RXRA(1) 3188314 42 27 42 23 28 3 1 6 4 0 0.752 1.000 1.000 478 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3D(4), CD3E(2), CD86(12), CTLA4(1), GRB2(2), HLA-DRA(5), ICOS(2), IL2(4), ITK(15), LCK(4), PIK3CA(2), PIK3R1(2), PTPN11(3) 1965520 58 27 56 29 42 4 1 3 8 0 0.581 1.000 1.000 479 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(1), ALDOB(5), ALDOC(1), FBP1(1), FPGT(2), GCK(8), GMDS(2), GMPPA(1), GMPPB(1), HK1(1), HK2(4), HK3(10), KHK(1), MPI(1), PFKFB1(1), PFKFB3(2), PFKFB4(4), SORD(1) 3657790 49 27 48 37 37 6 2 1 3 0 0.595 1.000 1.000 480 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(12), ACACB(12), FASN(9), OLAH(6), OXSM(1) 2431756 40 27 40 24 28 4 1 3 4 0 0.472 1.000 1.000 481 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), B4GALNT1(1), GLB1(5), HEXA(4), HEXB(2), LCT(24), SLC33A1(3), ST3GAL1(5), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC5(4), ST6GALNAC6(1), ST8SIA5(3) 2536315 57 27 57 33 41 5 0 8 3 0 0.475 1.000 1.000 482 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(1), ACOT11(5), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(2), EHHADH(5), GCDH(3), HADHA(7), MYST3(9), MYST4(11), NAT6(2), PNPLA3(1), SH3GLB1(1) 4024428 55 27 53 36 36 7 1 8 3 0 0.913 1.000 1.000 483 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(25), CYP2C9(24) 309583 49 27 46 29 42 2 2 0 3 0 0.420 1.000 1.000 484 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(11), AP2A1(1), BIN1(1), CALM2(1), DNM1(6), EPN1(4), EPS15(1), PICALM(1), PPP3CA(4), PPP3CB(1), SYNJ1(8), SYNJ2(9), SYT1(11) 3281840 59 27 59 30 46 4 2 6 1 0 0.456 1.000 1.000 485 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(13), CD38(3), ENPP1(7), ENPP3(8), NADSYN1(1), NMNAT2(2), NNMT(7), NNT(3), NT5E(3), NT5M(1), QPRT(4) 2241413 52 27 49 25 37 7 2 3 3 0 0.356 1.000 1.000 486 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(1), APC(11), AXIN1(6), BTRC(3), CTNNB1(5), DLL1(2), FZD1(1), GSK3B(1), NOTCH1(3), WNT1(1) 3236667 34 27 34 24 16 4 3 3 8 0 0.957 1.000 1.000 487 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 FOS(1), GRB2(2), JAK2(6), JUN(1), MAP2K1(3), MAPK3(1), MPL(1), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(5), RAF1(2), RASA1(1), SOS1(4), STAT1(2), STAT3(6), STAT5A(2), STAT5B(2), THPO(3) 4586222 50 27 49 30 31 5 3 7 4 0 0.850 1.000 1.000 488 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM2(1), CAMK1(4), CAMK1G(8), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CAMK4(8), CAMKK1(1), CAMKK2(3), SYT1(11) 1786213 47 26 47 32 36 4 2 3 2 0 0.682 1.000 1.000 489 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(1), ACO2(1), CS(1), FH(3), IDH1(6), IDH3A(2), IDH3G(2), MDH1(1), MDH2(1), PC(5), PCK1(15), SDHA(1) 3194631 39 26 35 25 29 1 3 3 3 0 0.644 1.000 1.000 490 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(1), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K6(2), MAPK1(2), MAPK14(4), MAPK3(1), NFKB1(1), PIK3CA(2), PIK3R1(2), RB1(3), RELA(1), SP1(3) 2962379 31 26 30 23 18 3 2 2 4 2 0.965 1.000 1.000 491 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(1), B3GAT2(1), B3GAT3(3), CHPF(2), CHST11(4), CHST12(1), CHST13(1), CHST14(2), CHSY1(5), DSE(8), XYLT1(8), XYLT2(1) 2037811 37 26 37 29 24 6 2 4 1 0 0.743 1.000 1.000 492 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(3), ACOX3(5), FADS2(2), PLA2G12B(3), PLA2G2A(1), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(12), PLA2G4A(7), PLA2G6(7) 1558193 49 26 49 29 36 5 0 4 4 0 0.445 1.000 1.000 493 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(4), IL22(1), IL22RA1(5), IL22RA2(1), JAK1(4), JAK2(6), JAK3(5), SOCS3(2), STAT1(2), STAT3(6), STAT5A(2), STAT5B(2), TYK2(3) 2794806 43 26 43 26 26 4 6 5 2 0 0.613 1.000 1.000 494 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(3), CSF1(7), CSF2(2), CSF3(1), HLA-DRA(5), IFNB1(4), IFNG(2), IL10(1), IL11(2), IL12A(2), IL12B(3), IL13(2), IL15(1), IL1A(2), IL2(4), IL3(2), IL4(1), IL5(4), IL7(3), IL8(1), LTA(2), PDGFA(1), TGFB2(1), TGFB3(1), TNF(1) 2020775 58 26 57 33 43 6 0 2 7 0 0.140 1.000 1.000 495 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 FOS(1), GRB2(2), INSR(11), IRS1(2), JUN(1), MAP2K1(3), MAPK3(1), PIK3CA(2), PIK3R1(2), PTPN11(3), RAF1(2), RASA1(1), SLC2A4(2), SOS1(4), SRF(1) 3930415 38 26 37 22 21 4 1 10 2 0 0.849 1.000 1.000 496 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH9A1(2), EHHADH(5), HADHA(7) 1866123 35 26 34 15 20 5 1 5 4 0 0.179 1.000 1.000 497 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(1), CALM2(1), CAPN2(2), EP300(7), HDAC1(1), MEF2D(2), NFATC1(9), NFATC2(4), PPP3CA(4), PPP3CB(1), PRKCA(5), SYT1(11) 3774805 48 26 48 28 36 4 3 3 2 0 0.666 1.000 1.000 498 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), GLB1(5), HEXA(4), HEXB(2), LCT(24), MANBA(2), NEU1(4), NEU2(10), NEU3(2), NEU4(5) 2530812 59 26 59 35 46 5 1 6 1 0 0.630 1.000 1.000 499 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(1), CCNE1(1), CDK4(2), CDKN1A(1), E2F1(5), MAPK1(2), MAPK3(1), NFKB1(1), NFKBIA(1), PAK1(2), PIK3CA(2), PIK3R1(2), RAC1(7), RAF1(2), RB1(3), RELA(1) 3092765 34 26 31 22 23 3 1 3 2 2 0.785 1.000 1.000 500 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(3), BIRC2(4), BIRC3(5), CASP10(3), CASP7(3), CASP8(1), CASP9(2), DFFA(1), DFFB(2), GZMB(1), PRF1(5), SCAP(4), SREBF1(2), SREBF2(6) 2795501 42 26 42 18 25 4 5 5 3 0 0.221 1.000 1.000 501 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(1), AKT2(6), AKT3(2), CDKN1A(1), GRB2(2), MAP2K1(3), MAP2K2(2), NGFR(6), NTRK1(9), PIK3CA(2), PIK3CD(2), SOS1(4) 2438395 40 26 39 16 24 6 2 5 3 0 0.234 1.000 1.000 502 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(5), CHUK(1), IFNG(2), IKBKB(2), IL2(4), IL4(1), JUN(1), MAP3K5(9), MAP4K5(2), MAPK14(4), NFKB1(1), NFKBIA(1), RELA(1), TNFRSF9(2), TNFSF9(1), TRAF2(1) 2938628 38 25 38 21 24 2 1 5 6 0 0.711 1.000 1.000 503 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(1), CHRNG(1), MUSK(18), PIK3CA(2), PIK3R1(2), PTK2(2), PTK2B(7), RAPSN(1), TERT(4) 2497676 38 25 37 38 30 2 0 5 1 0 0.985 1.000 1.000 504 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(18), MAP2(4), PPP1CA(1), PPP2CA(1), PRKACB(2), PRKACG(5), PRKAG1(1), PRKAR2A(1), PRKAR2B(3), PRKCE(3) 2778049 39 25 39 19 25 3 1 4 6 0 0.642 1.000 1.000 505 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(8), FOS(1), GRB2(2), IL3(2), IL3RA(4), JAK2(6), MAP2K1(3), MAPK3(1), PTPN6(1), RAF1(2), SOS1(4), STAT5A(2), STAT5B(2) 2696198 38 25 37 23 23 2 2 5 6 0 0.708 1.000 1.000 506 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(12), EP300(7), LPL(2), NCOA1(5), NCOA2(10), PPARG(6), RXRA(1) 2867268 43 25 42 18 32 4 1 3 3 0 0.441 1.000 1.000 507 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(4), CD3E(2), CD4(3), FYN(4), HLA-DRA(5), LCK(4), PTPRC(18), ZAP70(4) 1352543 44 25 41 26 34 4 0 4 2 0 0.578 1.000 1.000 508 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(3), ARHGDIB(1), BIRC2(4), BIRC3(5), CASP1(3), CASP10(3), CASP2(1), CASP4(1), CASP7(3), CASP8(1), CASP9(2), CYCS(1), DFFA(1), DFFB(2), GZMB(1), LMNA(3), LMNB2(4), PRF1(5) 3011786 44 24 44 14 26 7 4 6 1 0 0.0536 1.000 1.000 509 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(14), EGFR(13), ERBB3(2), NRG1(9) 1592880 38 24 38 22 29 1 1 4 3 0 0.797 1.000 1.000 510 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(8), IL13(2), IL4(1), IL5(4), MAF(1), MAP2K3(4), MAPK14(4), NFATC1(9), NFATC2(4), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3) 1849188 50 24 48 27 36 6 1 3 4 0 0.276 1.000 1.000 511 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(3), CYP11A1(8), CYP11B2(8), CYP17A1(4), HSD11B1(6), HSD3B1(1), HSD3B2(9) 1060122 39 24 38 34 28 3 0 3 5 0 0.614 1.000 1.000 512 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(2), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(2), HEMK1(1), LCMT1(3), METTL2B(5), PRMT2(1), PRMT3(3), PRMT5(3), PRMT6(1), PRMT7(1), PRMT8(7) 2322131 37 24 36 22 24 6 1 4 2 0 0.576 1.000 1.000 513 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 FOS(1), GRB2(2), IGF1(6), IGF1R(5), IRS1(2), JUN(1), MAP2K1(3), MAPK3(1), PIK3CA(2), PIK3R1(2), PTPN11(3), RAF1(2), RASA1(1), SOS1(4), SRF(1) 3798856 36 24 35 22 24 3 1 6 2 0 0.852 1.000 1.000 514 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM2(1), CDKN1A(1), GNAQ(1), MARCKS(1), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), PLCG1(4), PPP3CA(4), PPP3CB(1), PRKCA(5), SP1(3), SP3(1), SYT1(11) 3218386 54 23 54 30 40 6 3 2 3 0 0.642 1.000 1.000 515 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(8), CDC25A(5), CDC25B(1), CDC25C(3), CHEK1(1), MYT1(12) 2118623 30 23 29 20 23 1 1 2 3 0 0.879 1.000 1.000 516 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(2), ARPC1B(1), ARPC2(1), ARPC3(1), PAK1(2), PDGFRA(13), PIK3CA(2), PIK3R1(2), RAC1(7), WASL(1) 2068513 32 23 29 13 23 1 2 3 3 0 0.412 1.000 1.000 517 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(16), FHL5(5), FSHB(2), FSHR(9), GNAS(12) 1452160 44 23 43 28 34 2 2 3 3 0 0.772 1.000 1.000 518 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(1), EGF(14), EGFR(13), HGS(1), TF(4), TFRC(3) 1974307 36 23 36 24 26 1 3 3 3 0 0.865 1.000 1.000 519 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 RPL10L(5), RPL11(1), RPL14(1), RPL18(2), RPL18A(1), RPL21(1), RPL26(1), RPL27(2), RPL27A(1), RPL3(1), RPL30(1), RPL38(1), RPL3L(3), RPL7(2), RPS10(1), RPS13(1), RPS2(1), RPS20(1), RPS24(1), RPS27(1), RPS29(1), RPS5(1), RPS6(1), RPS7(1), RPSA(1) 3477754 34 23 34 20 19 3 3 7 2 0 0.654 1.000 1.000 520 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 FOS(1), GRB2(2), IL6R(2), IL6ST(4), JAK1(4), JAK2(6), JAK3(5), JUN(1), MAP2K1(3), MAPK3(1), PTPN11(3), RAF1(2), SOS1(4), SRF(1), STAT3(6) 3647694 45 23 44 26 26 5 2 8 4 0 0.778 1.000 1.000 521 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(1), CAT(3), GH1(1), GHR(14), IGF1(6), IGF1R(5), PIK3CA(2), PIK3R1(2) 2038530 34 23 34 20 27 2 0 3 2 0 0.652 1.000 1.000 522 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(1), B4GALT2(2), B4GALT3(1), B4GALT5(1), DDOST(1), DPAGT1(1), DPM1(1), FUT8(4), MAN1A1(8), MAN1B1(2), MGAT3(8), MGAT4A(5), MGAT5(1), RPN2(2), ST6GAL1(4) 3076368 43 23 42 31 30 4 0 3 6 0 0.787 1.000 1.000 523 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(3), HS3ST1(6), HS3ST2(6), HS3ST3B1(2), XYLT1(8), XYLT2(1) 976625 26 22 26 19 18 3 0 2 3 0 0.549 1.000 1.000 524 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(1), JUN(1), MAPK3(1), OPRK1(14), POLR2A(8), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3) 1974028 38 22 38 29 30 1 2 3 2 0 0.838 1.000 1.000 525 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 EPO(4), EPOR(1), FOS(1), GRB2(2), JAK2(6), JUN(1), MAP2K1(3), MAPK3(1), PLCG1(4), PTPN6(1), RAF1(2), SOS1(4), STAT5A(2), STAT5B(2) 3271132 34 22 33 21 21 1 3 6 3 0 0.793 1.000 1.000 526 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(3), HS3ST1(6), HS3ST2(6), HS3ST3B1(2), XYLT1(8), XYLT2(1) 976625 26 22 26 19 18 3 0 2 3 0 0.549 1.000 1.000 527 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B3GNT2(2), B3GNT7(3), B4GALT2(2), B4GALT3(1), CHST1(7), CHST2(1), CHST4(6), CHST6(4), FUT8(4), ST3GAL1(5) 1919257 36 22 35 17 27 6 2 0 1 0 0.0957 1.000 1.000 528 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(9), AMT(1), ATIC(1), FTCD(1), GART(5), MTFMT(1), MTHFD1(6), MTHFD2(2), MTHFR(1), MTR(5), SHMT2(2), TYMS(1) 2920068 35 22 35 22 22 3 0 5 5 0 0.735 1.000 1.000 529 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(4), CLOCK(2), CRY1(3), CRY2(1), CSNK1D(1), CSNK1E(3), NPAS2(3), PER1(2), PER2(9), PER3(6) 2617045 34 22 34 21 24 3 1 3 3 0 0.783 1.000 1.000 530 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(2), ARFGAP3(1), ARFGEF2(6), CLTA(1), CLTB(1), COPA(3), GBF1(7), GPLD1(13) 2528463 34 21 34 21 24 2 0 5 3 0 0.784 1.000 1.000 531 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(1), CCR5(4), CXCL12(1), FOS(1), GNAQ(1), JUN(1), MAPK14(4), PLCG1(4), PRKCA(5), PTK2B(7), SYT1(11) 2132477 40 21 40 32 28 2 1 5 4 0 0.895 1.000 1.000 532 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(1), GRB2(2), MAPK1(2), MAPK3(1), MAPK7(2), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), NTRK1(9), PIK3CA(2), PIK3R1(2), PLCG1(4), RPS6KA1(2) 2902220 35 21 35 30 28 3 1 2 1 0 0.953 1.000 1.000 533 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(1), KHK(1), LCT(24), MPI(1), PGM1(2), PYGL(2), PYGM(6), TREH(1) 2026842 38 21 38 36 31 3 0 2 2 0 0.899 1.000 1.000 534 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 GALNS(1), GLB1(5), GUSB(2), HEXA(4), HEXB(2), IDS(3), IDUA(3), LCT(24), NAGLU(2) 2196414 46 21 46 27 34 4 0 5 3 0 0.564 1.000 1.000 535 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(2), CHPT1(1), HEMK1(1), LCMT1(3), METTL2B(5), PCYT1A(2), PCYT1B(2), PRMT2(1), PRMT3(3), PRMT5(3), PRMT6(1), PRMT7(1), PRMT8(7) 2161418 32 21 31 14 21 4 2 2 3 0 0.243 1.000 1.000 536 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(2), B3GALNT1(4), B3GALT5(1), FUT1(3), FUT2(1), FUT9(13), GBGT1(1), HEXA(4), HEXB(2), ST3GAL1(5) 1649004 36 21 36 22 26 3 2 5 0 0 0.494 1.000 1.000 537 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(13), CD3D(4), CD3E(2), CD4(3), CD58(1), CD8A(1), CSF3(1), IL3(2), IL8(1), KITLG(6) 945217 34 21 32 21 25 1 1 4 3 0 0.548 1.000 1.000 538 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(4), CAMK1G(8), HDAC9(24), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2) 1137003 44 21 41 21 35 5 0 3 1 0 0.303 1.000 1.000 539 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(5), GAD1(6), HDC(8), PNMT(3), TH(6), TPH1(1) 918150 29 21 29 17 24 1 1 1 2 0 0.306 1.000 1.000 540 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(9), AMT(1), ATIC(1), GART(5), MTHFD1(6), MTHFD2(2), MTHFR(1), MTR(5), SHMT2(2), TYMS(1) 2757369 33 21 33 21 20 3 0 5 5 0 0.752 1.000 1.000 541 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(12), EP300(7), ESR1(2), MAPK1(2), MAPK3(1), PELP1(8) 2252584 32 21 32 15 24 3 1 2 2 0 0.464 1.000 1.000 542 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), AP2A1(1), BTK(6), EEA1(1), GSK3B(1), LYN(1), PDPK1(1), PFKL(2), PLCG1(4), PRKCE(3), PRKCZ(1), RAC1(7), RPS6KB1(1), VAV2(3) 3792391 33 21 30 24 21 1 2 3 6 0 0.735 1.000 1.000 543 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(1), CASP9(2), CHUK(1), H2AFX(1), MAP2K1(3), MAPK3(1), NFKB1(1), PIK3CA(2), PIK3R1(2), RAC1(7), RAF1(2), RALBP1(1), RALGDS(3), RELA(1) 2898419 28 21 24 23 22 4 0 2 0 0 0.923 1.000 1.000 544 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(4), F13B(13), HSD17B2(6), HSD17B3(5), HSD17B4(3), HSD3B1(1), HSD3B2(9) 1227220 41 21 41 20 31 1 3 2 3 1 0.214 1.000 1.000 545 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(12), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKCA(5) 1452995 31 20 31 17 25 1 1 2 2 0 0.594 1.000 1.000 546 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(1), CASP9(2), CHUK(1), GH1(1), GHR(14), NFKB1(1), NFKBIA(1), PDPK1(1), PIK3CA(2), PIK3R1(2), PPP2CA(1), RELA(1) 2146027 28 20 28 24 21 2 2 1 2 0 0.975 1.000 1.000 547 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(3), ANKRD1(1), CYR61(1), DUSP14(1), IFNG(2), IL18(2), IL1A(2), IL1R1(6), MYOG(2), NR4A3(5), WDR1(2) 1633937 27 20 26 14 18 1 0 2 6 0 0.587 1.000 1.000 548 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), MAP3K14(1), MAPK14(4), NFKB1(1), RELA(1), TNFRSF13B(6), TNFRSF17(3), TRAF2(1), TRAF3(3), TRAF5(4), TRAF6(2) 2210837 27 20 27 17 21 1 0 3 2 0 0.749 1.000 1.000 549 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(3), FOS(1), FYN(4), JUN(1), MAPK14(4), THBS1(15) 1140650 28 20 28 20 15 1 2 6 4 0 0.927 1.000 1.000 550 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 GCK(8), GFPT1(1), GNE(2), HEXA(4), HEXB(2), HK1(1), HK2(4), HK3(10), PGM3(1), UAP1(1) 2610904 34 19 33 20 24 2 1 4 3 0 0.601 1.000 1.000 551 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), BCL2(2), CASP8(1), CYCS(1), MAP2K1(3), MAP2K4(3), MAPK1(2), MAPK3(1), NFKB1(1), NSMAF(3), RAF1(2), RELA(1), RIPK1(1), SMPD1(1), TNFRSF1A(2), TRAF2(1) 3130824 26 19 25 20 20 3 2 1 0 0 0.887 1.000 1.000 552 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP51A1(1), DHCR24(1), DHCR7(5), FDPS(2), GGCX(2), HMGCR(7), LSS(2), MVK(1), NQO1(1), NSDHL(2), PMVK(1), SC4MOL(3), SQLE(1) 2966127 29 19 28 15 16 4 1 5 3 0 0.461 1.000 1.000 553 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), BLVRB(1), HMOX1(1), IL10(1), IL10RA(4), IL10RB(2), IL1A(2), JAK1(4), STAT1(2), STAT3(6), STAT5A(2), TNF(1) 1880252 27 19 27 14 15 3 3 2 4 0 0.299 1.000 1.000 554 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 FOS(1), GRB2(2), JUN(1), KLK2(1), MAP2K1(3), MAPK3(1), NGFR(6), PIK3CA(2), PIK3R1(2), PLCG1(4), RAF1(2), SOS1(4) 2919311 29 19 28 22 22 3 0 2 2 0 0.935 1.000 1.000 555 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(4), IFNAR2(3), IFNB1(4), NFKB1(1), RELA(1), TNFRSF11A(3), TNFSF11(3), TRAF6(2) 1703769 22 19 22 18 19 0 0 1 2 0 0.946 1.000 1.000 556 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(1), CREBBP(12), EP300(7), HDAC3(3), IKBKB(2), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF6(2) 3433912 35 19 35 18 23 4 3 2 3 0 0.576 1.000 1.000 557 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ASL(2), CKM(1), CKMT1A(1), CKMT2(5), CPS1(12), GAMT(2), GATM(1), GLUD1(1), OAT(1), ODC1(2), OTC(2), SMS(1) 2647476 31 19 31 16 21 4 3 2 1 0 0.395 1.000 1.000 558 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(13), GNA12(2), PRKACB(2), PRKACG(5), PRKAG1(1), PRKAR2A(1), PRKAR2B(3) 1554169 27 18 27 14 23 1 0 2 1 0 0.449 1.000 1.000 559 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(3), EGR1(1), KLK2(1), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK3(1), NGFR(6), RAF1(2) 1244694 21 18 20 14 14 2 1 1 3 0 0.582 1.000 1.000 560 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(5), FDPS(2), HMGCR(7), HMGCS1(1), LSS(2), MVK(1), NSDHL(2), PMVK(1), SC4MOL(3), SQLE(1) 2025307 26 18 25 10 15 4 0 4 3 0 0.247 1.000 1.000 561 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(6), CDO1(2), CSAD(2), GAD1(6), GAD2(3), GGT1(3) 869298 22 18 21 14 14 2 1 4 1 0 0.648 1.000 1.000 562 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(2), MYST3(9), MYST4(11), NAT6(2), PNPLA3(1), SH3GLB1(1) 2569914 34 18 33 27 22 5 1 4 2 0 0.983 1.000 1.000 563 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(1), GRB2(2), IGF1R(5), IRS1(2), MAP2K1(3), MAPK1(2), MAPK3(1), PIK3CA(2), PIK3R1(2), RAF1(2), SOS1(4) 2923948 26 18 25 14 19 3 1 2 1 0 0.609 1.000 1.000 564 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), GRB2(2), IL2RG(2), IL4(1), IL4R(5), IRS1(2), JAK1(4), JAK3(5), RPS6KB1(1), STAT6(2) 2266975 25 18 25 14 16 2 2 2 3 0 0.627 1.000 1.000 565 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(7), CD4(3), HLA-DRA(5), IL1B(2), IL4(1), IL5(4), IL5RA(7) 822463 29 18 28 24 23 1 0 2 3 0 0.742 1.000 1.000 566 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(9), MBTPS1(3), SCAP(4), SREBF1(2), SREBF2(6) 1818366 25 18 25 17 16 2 2 2 3 0 0.750 1.000 1.000 567 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(4), CDKN1A(1), EPO(4), EPOR(1), GRIN1(6), JAK2(6), NFKB1(1), NFKBIA(1), RELA(1) 1926613 25 17 25 13 11 2 4 3 5 0 0.658 1.000 1.000 568 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(4), FARSB(2), GOT1(4), GOT2(2), PAH(3), TAT(10), YARS2(1) 1343645 26 17 25 15 19 2 2 2 1 0 0.493 1.000 1.000 569 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 SEC22B(3), SNAP25(5), STX11(1), STX16(2), STX17(1), STX19(1), STX5(1), STX6(1), TSNARE1(2), VAMP4(1), VAMP7(2), VAMP8(1), VTI1A(1), VTI1B(1) 2542826 23 17 22 13 15 1 0 4 3 0 0.505 1.000 1.000 570 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(2), IL13RA2(1), IL4R(5), JAK1(4), JAK2(6), TYK2(3) 1607371 23 17 23 12 15 1 2 3 2 0 0.562 1.000 1.000 571 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(2), IL13RA2(1), IL4R(5), JAK1(4), JAK2(6), TYK2(3) 1607371 23 17 23 12 15 1 2 3 2 0 0.562 1.000 1.000 572 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(1), GRB2(2), KLK2(1), NTRK1(9), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(5), SOS1(4) 2385523 30 17 30 20 22 3 1 2 2 0 0.846 1.000 1.000 573 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH9A1(2) 1223045 23 16 23 12 12 4 1 2 4 0 0.363 1.000 1.000 574 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH9A1(2) 1223045 23 16 23 12 12 4 1 2 4 0 0.363 1.000 1.000 575 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(3), ARHGAP5(7), ARHGDIB(1), CASP1(3), CASP10(3), CASP8(1), CASP9(2), CYCS(1), GZMB(1), JUN(1), PRF1(5) 1994238 28 16 28 14 20 3 1 3 1 0 0.542 1.000 1.000 576 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), ACO2(1), CS(1), HAO1(4), HAO2(7), HYI(1), MDH1(1), MDH2(1), MTHFD1(6), MTHFD2(2) 1970372 25 16 25 15 16 1 2 3 3 0 0.603 1.000 1.000 577 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(5), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(2), PON1(8), PON2(1), PON3(4), RDH12(1), RDH13(3) 1393074 32 16 31 20 24 2 0 3 3 0 0.484 1.000 1.000 578 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(8), HK1(1), HK2(4), HK3(10), IMPA1(1), IMPA2(1), ISYNA1(1), PGM1(2), PGM3(1), TGDS(1) 1791327 30 16 29 18 22 2 0 2 4 0 0.507 1.000 1.000 579 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(4), B3GALT1(8), B3GALT2(1), B3GALT5(1), B3GNT5(1), FUT1(3), FUT2(1), FUT3(3) 1105506 22 16 22 19 18 2 0 1 1 0 0.815 1.000 1.000 580 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), ACO2(1), CS(1), HAO1(4), HAO2(7), HYI(1), MDH1(1), MDH2(1), MTHFD1(6), MTHFD2(2) 2063411 25 16 25 17 16 1 2 3 3 0 0.729 1.000 1.000 581 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(4), CHST12(1), CHST13(1), PAPSS1(1), PAPSS2(2), SULT1A1(8), SULT1E1(7), SULT2A1(4), SULT2B1(5), SUOX(2) 1401942 35 16 35 21 27 2 0 3 3 0 0.507 1.000 1.000 582 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(1), ESR1(2), GREB1(15), HSPB1(1), HSPB2(1), MTA1(1), MTA3(1), TUBA8(1) 1637287 24 16 23 15 17 2 2 1 2 0 0.490 1.000 1.000 583 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(4), JAK2(6), JAK3(5), MAPK1(2), MAPK3(1), STAT3(6), TYK2(3) 1784850 27 16 27 21 16 3 3 3 2 0 0.866 1.000 1.000 584 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(3), NRF1(3), UBE2D3(2), UBE2I(1), UBE2J1(1), UBE2J2(3), UBE2L6(1), UBE2M(1), UBE2S(1), UBE3A(5) 1629943 21 16 20 10 17 3 0 1 0 0 0.487 1.000 1.000 585 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR2(3), IFNB1(4), JAK1(4), STAT1(2), STAT2(5), TYK2(3) 1659071 21 15 21 13 14 1 1 3 2 0 0.700 1.000 1.000 586 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(4), CAPN1(1), CDK5(3), CSNK1A1(1), CSNK1D(1), GSK3B(1), MAPT(4), PPP2CA(1) 1382889 16 15 16 10 11 0 1 1 3 0 0.755 1.000 1.000 587 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(8), HK1(1), HK2(4), HK3(10), IMPA1(1), PGM1(2), PGM3(1), TGDS(1) 1575045 28 15 27 16 22 2 0 1 3 0 0.455 1.000 1.000 588 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(1), IKBKAP(3), IKBKB(2), LTA(2), MAP3K14(1), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(1), TNFAIP3(1), TNFRSF1B(1), TRAF1(4), TRAF2(1), TRAF3(3) 3428466 23 15 23 27 17 1 1 2 2 0 0.997 1.000 1.000 589 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(1), ADORA2A(1), ADORA2B(1), ADORA3(10), P2RY1(1), P2RY2(3), P2RY6(1) 917392 18 14 18 18 13 2 0 1 2 0 0.582 1.000 1.000 590 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO3(1), GOT1(4), GOT2(2), PAH(3), TAT(10) 1287663 22 14 22 13 19 0 2 1 0 0 0.411 1.000 1.000 591 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(4), FUT1(3), FUT2(1), FUT3(3), FUT5(6), FUT6(1) 770236 18 13 18 13 12 2 1 0 3 0 0.503 1.000 1.000 592 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), IKBKAP(3), IKBKB(2), MAP3K14(1), NFKB1(1), NFKBIA(1), RELA(1), TNFAIP3(1), TRAF3(3), TRAF6(2) 2776403 16 13 16 18 11 1 1 2 1 0 0.993 1.000 1.000 593 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(7), EIF2AK4(6), EIF2B5(1), EIF2S1(1), GSK3B(1), PPP1CA(1) 1795655 17 13 16 10 11 0 0 4 2 0 0.849 1.000 1.000 594 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(5), ENO1(2), GPI(2), HK1(1), PFKL(2), PGK1(1), PKLR(6) 1411295 19 13 19 12 14 0 1 1 3 0 0.388 1.000 1.000 595 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(5), CDC25B(1), CDC25C(3), CSK(1), GRB2(2), PRKCA(5), PTPRA(2) 1432602 19 13 19 14 13 2 1 1 2 0 0.833 1.000 1.000 596 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 FOS(1), JUN(1), KEAP1(1), MAPK1(2), MAPK14(4), NFE2L2(1), PRKCA(5) 1364837 15 12 15 12 8 1 0 3 3 0 0.937 1.000 1.000 597 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(1), BDH1(2), HMGCL(2), HMGCS1(1), HMGCS2(11), OXCT1(3), OXCT2(2) 1100438 22 12 21 10 16 3 0 2 1 0 0.406 1.000 1.000 598 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(4), HGD(10) 347204 14 12 14 12 10 2 2 0 0 0 0.855 1.000 1.000 599 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(5), ACO1(1), ACO2(1), ACSS2(3), FH(3), IDH1(6), MDH1(1), MDH2(1) 2063866 21 12 18 14 15 0 2 2 2 0 0.666 1.000 1.000 600 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(3), PLCG1(4), PRKCA(5), PTK2B(7) 1042770 19 12 19 16 15 2 0 0 2 0 0.757 1.000 1.000 601 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(6), MTHFD2(2), POLD1(2), POLG(4), PRPS2(1), RRM1(2) 1906408 17 12 17 10 9 2 1 2 3 0 0.627 1.000 1.000 602 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(3), HLA-DRA(5), IL10(1), IL2(4), IL4(1) 606585 14 11 14 15 10 1 0 1 2 0 0.906 1.000 1.000 603 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2), MIOX(3) 1302700 17 11 17 14 10 3 1 0 3 0 0.807 1.000 1.000 604 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(3), APOBEC1(3), APOBEC2(3), APOBEC3A(1), APOBEC3B(1), APOBEC3C(2), APOBEC3G(1) 1140250 14 11 14 9 10 2 2 0 0 0 0.659 1.000 1.000 605 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(5), GOT1(4), GOT2(2), TAT(10), TYR(2) 725401 23 11 23 16 19 0 2 1 1 0 0.761 1.000 1.000 606 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(2), PTK2B(7), SOS1(4) 1351901 13 10 13 10 11 0 0 1 1 0 0.888 1.000 1.000 607 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(1), COQ3(2), COQ6(1), NDUFA12(1), NDUFA13(5) 613192 10 10 9 7 7 1 2 0 0 0 0.836 1.000 1.000 608 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(13), PSAT1(1) 749043 14 10 13 11 13 1 0 0 0 0 0.804 1.000 1.000 609 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CSF1(7), LDLR(9), LPL(2) 826479 18 10 18 13 15 3 0 0 0 0 0.665 1.000 1.000 610 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(7), IL1B(2), MST1(1), MST1R(4), TNF(1) 1008413 15 10 15 13 11 2 0 0 2 0 0.849 1.000 1.000 611 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(1), DLL1(2), FURIN(2), NOTCH1(3) 1418128 8 8 8 12 4 2 1 1 0 0 0.984 1.000 1.000 612 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(3), HLA-DRA(5) 362573 8 7 8 12 6 1 0 1 0 0 0.976 1.000 1.000 613 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(4), CD3D(4), CD3E(2), CD4(3) 494848 13 7 13 15 9 1 0 2 1 0 0.941 1.000 1.000 614 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(4), GLS(1), GLUD1(1), OAT(1), PRODH(1) 834276 8 5 8 11 3 2 2 1 0 0 0.991 1.000 1.000 615 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(10) 281945 10 4 10 8 8 1 1 0 0 0 0.790 1.000 1.000 616 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2) 327266 2 2 2 3 1 0 0 1 0 0 0.953 1.000 1.000