E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.1 0.192 -9999.0 0.0 -0.384 35.0 35.0 KLHL20 -0.022 0.083 -9999.0 0.0 -0.199 6.0 6.0 CYFIP2 -0.013 0.103 -9999.0 0.0 -0.411 7.0 7.0 Rac1/GDP -0.041 0.122 -9999.0 0.0 -0.215 34.0 34.0 ENAH -0.103 0.195 -9999.0 0.0 -0.389 35.0 35.0 AP1M1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.045 0.065 -9999.0 0.0 -0.268 1.0 1.0 ABI1/Sra1/Nap1 -0.037 0.045 -9999.0 0.0 -0.135 9.0 9.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.054 0.124 -9999.0 0.0 -0.218 38.0 38.0 RAPGEF1 -0.079 0.172 -9999.0 0.0 -0.333 35.0 35.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.107 0.198 -9999.0 0.0 -0.399 35.0 35.0 CRK -0.09 0.185 -9999.0 0.0 -0.363 35.0 35.0 E-cadherin/gamma catenin/alpha catenin -0.058 0.122 -9999.0 0.0 -0.234 35.0 35.0 alphaE/beta7 Integrin 0.004 0.068 -9999.0 0.0 -0.282 6.0 6.0 IQGAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.023 0.031 -9999.0 0.0 -0.207 2.0 2.0 DLG1 -0.099 0.192 -9999.0 0.0 -0.384 35.0 35.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.034 0.048 -9999.0 0.0 -0.194 1.0 1.0 MLLT4 0.006 0.056 -9999.0 0.0 -0.411 2.0 2.0 ARF6/GTP/NME1/Tiam1 0.016 0.048 -9999.0 0.0 -0.207 5.0 5.0 PI3K -0.042 0.059 -9999.0 0.0 -0.249 1.0 1.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.08 0.143 -9999.0 0.0 -0.277 38.0 38.0 TIAM1 -0.005 0.088 -9999.0 0.0 -0.411 5.0 5.0 E-cadherin(dimer)/Ca2+ -0.04 0.103 -9999.0 0.0 -0.189 35.0 35.0 AKT1 -0.024 0.035 -9999.0 0.0 -0.142 1.0 1.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.126 0.197 -9999.0 0.0 -0.399 38.0 38.0 RhoA/GDP -0.042 0.122 -9999.0 0.0 -0.215 35.0 35.0 actin cytoskeleton organization -0.015 0.063 -9999.0 0.0 -0.146 6.0 6.0 CDC42/GDP -0.042 0.122 -9999.0 0.0 -0.216 34.0 34.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.051 0.104 -9999.0 0.0 -0.204 35.0 35.0 ITGB7 -0.009 0.096 -9999.0 0.0 -0.411 6.0 6.0 RAC1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.042 0.11 -9999.0 0.0 -0.202 35.0 35.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.047 0.101 -9999.0 0.0 -0.194 35.0 35.0 mol:GDP -0.056 0.136 -9999.0 0.0 -0.25 35.0 35.0 CDC42/GTP/IQGAP1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.011 0.025 -9999.0 0.0 -0.257 1.0 1.0 p120 catenin/RhoA/GDP -0.042 0.123 -9999.0 0.0 -0.219 34.0 34.0 RAC1/GTP/IQGAP1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.008 0.046 -9999.0 0.0 -0.111 6.0 6.0 NME1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.101 0.192 -9999.0 0.0 -0.384 35.0 35.0 regulation of cell-cell adhesion -0.041 0.058 -9999.0 0.0 -0.236 1.0 1.0 WASF2 -0.019 0.024 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.024 0.093 -9999.0 0.0 -0.305 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.045 0.12 -9999.0 0.0 -0.203 38.0 38.0 CCND1 -0.01 0.055 -9999.0 0.0 -0.135 6.0 6.0 VAV2 -0.109 0.212 -9999.0 0.0 -0.387 39.0 39.0 RAP1/GDP -0.031 0.103 -9999.0 0.0 -0.333 1.0 1.0 adherens junction assembly -0.098 0.187 -9999.0 0.0 -0.373 35.0 35.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.01 0.04 -9999.0 0.0 -0.411 1.0 1.0 PIP5K1C 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.039 0.114 -9999.0 0.0 -0.344 4.0 4.0 E-cadherin/beta catenin -0.087 0.145 -9999.0 0.0 -0.302 35.0 35.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.101 0.195 -9999.0 0.0 -0.389 35.0 35.0 PIK3CA 0.01 0.04 -9999.0 0.0 -0.411 1.0 1.0 Rac1/GTP -0.073 0.098 -9999.0 0.0 -0.319 6.0 6.0 E-cadherin/beta catenin/alpha catenin -0.057 0.12 -9999.0 0.0 -0.23 35.0 35.0 ITGAE 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.109 0.201 -9999.0 0.0 -0.407 35.0 35.0