Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.038 0.191 -9999.0 0.0 -0.587 10.0 10.0 IHH -0.001 0.05 -9999.0 0.0 -0.232 1.0 1.0 SHH Np/Cholesterol/GAS1 0.0 0.06 -9999.0 0.0 -0.231 6.0 6.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.0 0.06 0.23 6.0 -9999.0 0.0 6.0 SMO/beta Arrestin2 -0.037 0.159 -9999.0 0.0 -0.451 10.0 10.0 SMO -0.045 0.166 -9999.0 0.0 -0.459 11.0 11.0 AKT1 -0.004 0.081 -9999.0 0.0 -0.25 2.0 2.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.013 0.095 -9999.0 0.0 -0.326 9.0 9.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.045 0.164 -9999.0 0.0 -0.452 11.0 11.0 STIL -0.019 0.116 -9999.0 0.0 -0.356 8.0 8.0 DHH N/PTCH2 -0.017 0.091 -9999.0 0.0 -0.224 17.0 17.0 DHH N/PTCH1 -0.034 0.147 -9999.0 0.0 -0.374 12.0 12.0 PIK3CA 0.01 0.04 -9999.0 0.0 -0.411 1.0 1.0 DHH -0.032 0.115 -9999.0 0.0 -0.305 16.0 16.0 PTHLH -0.054 0.249 -9999.0 0.0 -0.791 10.0 10.0 determination of left/right symmetry -0.045 0.164 -9999.0 0.0 -0.452 11.0 11.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.054 0.246 -9999.0 0.0 -0.781 10.0 10.0 IHH N/Hhip -0.0 0.052 -9999.0 0.0 -0.191 6.0 6.0 DHH N/Hhip -0.023 0.091 -9999.0 0.0 -0.21 20.0 20.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.045 0.164 -9999.0 0.0 -0.452 11.0 11.0 pancreas development -0.005 0.06 -9999.0 0.0 -0.257 6.0 6.0 HHAT -0.001 0.079 -9999.0 0.0 -0.411 4.0 4.0 PI3K 0.018 0.028 -9999.0 0.0 -0.282 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.006 0.056 -9999.0 0.0 -0.411 2.0 2.0 somite specification -0.045 0.164 -9999.0 0.0 -0.452 11.0 11.0 SHH Np/Cholesterol/PTCH1 -0.02 0.121 -9999.0 0.0 -0.379 8.0 8.0 SHH Np/Cholesterol/PTCH2 -0.0 0.055 -9999.0 0.0 -0.212 5.0 5.0 SHH Np/Cholesterol/Megalin -0.096 0.108 -9999.0 0.0 -0.243 28.0 28.0 SHH -0.006 0.064 -9999.0 0.0 -0.226 8.0 8.0 catabolic process -0.02 0.14 -9999.0 0.0 -0.419 10.0 10.0 SMO/Vitamin D3 -0.031 0.141 -9999.0 0.0 -0.417 10.0 10.0 SHH Np/Cholesterol/Hhip -0.005 0.061 -9999.0 0.0 -0.242 5.0 5.0 LRP2 -0.181 0.175 -9999.0 0.0 -0.321 65.0 65.0 receptor-mediated endocytosis -0.096 0.163 -9999.0 0.0 -0.474 12.0 12.0 SHH Np/Cholesterol/BOC -0.01 0.067 -9999.0 0.0 -0.212 8.0 8.0 SHH Np/Cholesterol/CDO 0.0 0.069 -9999.0 0.0 -0.316 4.0 4.0 mesenchymal cell differentiation 0.005 0.061 0.24 5.0 -9999.0 0.0 5.0 mol:Vitamin D3 -0.017 0.122 -9999.0 0.0 -0.38 8.0 8.0 IHH N/PTCH2 0.007 0.05 -9999.0 0.0 -0.242 3.0 3.0 CDON 0.006 0.056 -9999.0 0.0 -0.411 2.0 2.0 IHH N/PTCH1 -0.017 0.142 -9999.0 0.0 -0.421 10.0 10.0 Megalin/LRPAP1 -0.115 0.123 -9999.0 0.0 -0.213 65.0 65.0 PTCH2 0.005 0.053 -9999.0 0.0 -0.308 3.0 3.0 SHH Np/Cholesterol -0.003 0.048 -9999.0 0.0 -0.218 4.0 4.0 PTCH1 -0.02 0.141 -9999.0 0.0 -0.42 10.0 10.0 HHIP -0.005 0.06 -9999.0 0.0 -0.257 6.0 6.0