Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.045 0.102 -9999.0 0.0 -0.195 35.0 35.0 epithelial cell differentiation -0.041 0.1 -9999.0 0.0 -0.187 35.0 35.0 CYFIP2 -0.013 0.103 -9999.0 0.0 -0.411 7.0 7.0 ENAH -0.015 0.077 -9999.0 0.0 -0.207 3.0 3.0 EGFR -0.014 0.093 -9999.0 0.0 -0.303 10.0 10.0 EPHA2 -0.005 0.08 -9999.0 0.0 -0.334 6.0 6.0 MYO6 -0.043 0.101 -9999.0 0.0 -0.182 37.0 37.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.01 0.066 -9999.0 0.0 -0.23 8.0 8.0 AQP5 -0.039 0.085 -9999.0 0.0 -0.215 5.0 5.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.037 0.093 -9999.0 0.0 -0.172 35.0 35.0 regulation of calcium-dependent cell-cell adhesion -0.048 0.101 -9999.0 0.0 -0.184 37.0 37.0 EGF -0.098 0.176 -9999.0 0.0 -0.364 33.0 33.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.047 0.132 -9999.0 0.0 -0.47 6.0 6.0 cortical microtubule organization -0.041 0.1 -9999.0 0.0 -0.187 35.0 35.0 GO:0000145 -0.037 0.088 -9999.0 0.0 -0.164 35.0 35.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.04 0.103 -9999.0 0.0 -0.189 35.0 35.0 MLLT4 0.006 0.056 -9999.0 0.0 -0.411 2.0 2.0 ARF6/GDP -0.05 0.068 -9999.0 0.0 -0.237 2.0 2.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.026 0.044 -9999.0 0.0 -0.202 3.0 3.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.031 0.09 -9999.0 0.0 -0.205 1.0 1.0 PVRL2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.039 0.096 -9999.0 0.0 -0.177 35.0 35.0 ARF6/GTP 0.03 0.041 -9999.0 0.0 -0.182 3.0 3.0 CDH1 -0.126 0.197 -9999.0 0.0 -0.399 38.0 38.0 EGFR/EGFR/EGF/EGF -0.109 0.133 -9999.0 0.0 -0.238 48.0 48.0 RhoA/GDP -0.036 0.094 -9999.0 0.0 -0.173 35.0 35.0 actin cytoskeleton organization -0.039 0.099 -9999.0 0.0 -0.176 36.0 36.0 IGF-1R heterotetramer 0.01 0.04 -9999.0 0.0 -0.411 1.0 1.0 GIT1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.01 0.04 -9999.0 0.0 -0.411 1.0 1.0 IGF1 -0.029 0.125 -9999.0 0.0 -0.385 12.0 12.0 DIAPH1 -0.033 0.146 -9999.0 0.0 -0.559 8.0 8.0 Wnt receptor signaling pathway 0.041 0.1 0.187 35.0 -9999.0 0.0 35.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.051 0.068 -9999.0 0.0 -0.237 2.0 2.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.04 0.101 -9999.0 0.0 -0.179 36.0 36.0 EFNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.037 0.091 -9999.0 0.0 -0.164 3.0 3.0 Ephrin A1/EPHA2 -0.06 0.081 -9999.0 0.0 -0.273 2.0 2.0 SEC6/SEC8 -0.05 0.068 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.049 0.102 -9999.0 0.0 -0.186 37.0 37.0 HGF/MET -0.088 0.108 -9999.0 0.0 -0.32 12.0 12.0 HGF -0.017 0.102 -9999.0 0.0 -0.334 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.045 0.103 -9999.0 0.0 -0.196 35.0 35.0 actin cable formation -0.007 0.08 -9999.0 0.0 -0.261 2.0 2.0 KIAA1543 -0.063 0.111 -9999.0 0.0 -0.194 39.0 39.0 KIFC3 -0.04 0.095 -9999.0 0.0 -0.174 36.0 36.0 NCK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.043 0.096 -9999.0 0.0 -0.174 38.0 38.0 NCK1/GIT1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.041 0.1 -9999.0 0.0 -0.187 35.0 35.0 EXOC4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.038 0.094 -9999.0 0.0 -0.174 35.0 35.0 PIP5K1C -0.038 0.094 -9999.0 0.0 -0.174 35.0 35.0 LIMA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.01 0.04 -9999.0 0.0 -0.411 1.0 1.0 ROCK1 -0.02 0.082 -9999.0 0.0 -0.209 2.0 2.0 adherens junction assembly -0.049 0.107 -9999.0 0.0 -0.368 3.0 3.0 IGF-1R heterotetramer/IGF1 -0.072 0.098 -9999.0 0.0 -0.339 6.0 6.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.015 0.04 -9999.0 0.0 -0.282 2.0 2.0 MET -0.042 0.136 -9999.0 0.0 -0.357 17.0 17.0 PLEKHA7 -0.046 0.106 -9999.0 0.0 -0.191 36.0 36.0 mol:GTP 0.024 0.044 -9999.0 0.0 -0.201 3.0 3.0 establishment of epithelial cell apical/basal polarity -0.019 0.085 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.045 0.102 -9999.0 0.0 -0.195 35.0 35.0 regulation of cell-cell adhesion -0.039 0.099 -9999.0 0.0 -0.176 36.0 36.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.045 0.103 -9999.0 0.0 -0.196 35.0 35.0