E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.104 0.185 -9999.0 0.0 -0.371 36.0 36.0 KLHL20 -0.023 0.096 0.201 4.0 -0.204 9.0 13.0 CYFIP2 0.013 0.067 -9999.0 0.0 -0.295 5.0 5.0 Rac1/GDP -0.057 0.117 -9999.0 0.0 -0.218 34.0 34.0 ENAH -0.088 0.176 -9999.0 0.0 -0.376 30.0 30.0 AP1M1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.023 0.085 0.139 1.0 -0.148 28.0 29.0 ABI1/Sra1/Nap1 -0.039 0.051 -9999.0 0.0 -0.138 10.0 10.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.004 0.108 -9999.0 0.0 -0.159 35.0 35.0 RAPGEF1 -0.084 0.172 0.213 2.0 -0.333 34.0 36.0 CTNND1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.099 0.194 -9999.0 0.0 -0.378 36.0 36.0 CRK -0.091 0.179 0.21 1.0 -0.353 34.0 35.0 E-cadherin/gamma catenin/alpha catenin -0.011 0.104 -9999.0 0.0 -0.171 32.0 32.0 alphaE/beta7 Integrin 0.031 0.046 -9999.0 0.0 -0.197 4.0 4.0 IQGAP1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.044 0.035 -9999.0 0.0 -0.155 2.0 2.0 DLG1 -0.103 0.186 -9999.0 0.0 -0.371 36.0 36.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.043 0.047 -9999.0 0.0 -0.116 28.0 28.0 MLLT4 0.02 0.044 -9999.0 0.0 -0.295 2.0 2.0 ARF6/GTP/NME1/Tiam1 0.046 0.038 -9999.0 0.0 -0.155 3.0 3.0 PI3K -0.053 0.059 -9999.0 0.0 -0.146 28.0 28.0 ARF6 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.028 0.112 -9999.0 0.0 -0.203 32.0 32.0 TIAM1 0.02 0.053 -9999.0 0.0 -0.295 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.004 0.098 -9999.0 0.0 -0.147 32.0 32.0 AKT1 -0.026 0.05 0.109 2.0 -0.127 1.0 3.0 PIK3R1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.063 0.147 0.111 2.0 -0.295 32.0 34.0 RhoA/GDP -0.049 0.129 0.263 1.0 -0.219 34.0 35.0 actin cytoskeleton organization -0.014 0.076 0.17 5.0 -0.15 9.0 14.0 CDC42/GDP -0.05 0.129 0.225 2.0 -0.218 35.0 37.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.038 0.09 -9999.0 0.0 -0.179 32.0 32.0 ITGB7 0.018 0.06 -9999.0 0.0 -0.295 4.0 4.0 RAC1 0.026 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.004 0.105 -9999.0 0.0 -0.158 32.0 32.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.007 0.088 -9999.0 0.0 -0.144 32.0 32.0 mol:GDP -0.067 0.136 0.226 2.0 -0.245 35.0 37.0 CDC42/GTP/IQGAP1 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.043 0.135 0.268 1.0 -0.226 32.0 33.0 RAC1/GTP/IQGAP1 0.034 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.044 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.005 0.059 0.134 8.0 -0.099 6.0 14.0 NME1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.1 0.185 -9999.0 0.0 -0.372 35.0 35.0 regulation of cell-cell adhesion -0.03 0.067 -9999.0 0.0 -0.132 30.0 30.0 WASF2 -0.011 0.042 0.09 3.0 -0.083 5.0 8.0 Rap1/GTP -0.026 0.093 0.168 5.0 -0.161 28.0 33.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.003 0.109 -9999.0 0.0 -0.153 34.0 34.0 CCND1 -0.007 0.069 0.153 8.0 -0.117 7.0 15.0 VAV2 -0.116 0.237 -9999.0 0.0 -0.604 10.0 10.0 RAP1/GDP -0.032 0.106 0.19 1.0 -0.177 31.0 32.0 adherens junction assembly -0.097 0.179 -9999.0 0.0 -0.361 35.0 35.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.032 -9999.0 0.0 -0.295 1.0 1.0 PIP5K1C 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.006 0.101 0.19 2.0 -0.15 34.0 36.0 E-cadherin/beta catenin -0.065 0.125 -9999.0 0.0 -0.267 31.0 31.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.102 0.182 -9999.0 0.0 -0.37 35.0 35.0 PIK3CA 0.026 0.031 -9999.0 0.0 -0.295 1.0 1.0 Rac1/GTP -0.072 0.116 -9999.0 0.0 -0.32 9.0 9.0 E-cadherin/beta catenin/alpha catenin -0.01 0.104 -9999.0 0.0 -0.172 32.0 32.0 ITGAE 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.101 0.197 -9999.0 0.0 -0.386 36.0 36.0