Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.035 0.092 -9999.0 0.0 -0.176 33.0 33.0 epithelial cell differentiation -0.0 0.094 -9999.0 0.0 -0.146 32.0 32.0 CYFIP2 0.013 0.067 -9999.0 0.0 -0.295 5.0 5.0 ENAH -0.046 0.057 -9999.0 0.0 -0.207 1.0 1.0 EGFR 0.023 0.057 -9999.0 0.0 -0.295 3.0 3.0 EPHA2 0.023 0.055 -9999.0 0.0 -0.295 3.0 3.0 MYO6 -0.046 0.071 0.173 3.0 -0.268 1.0 4.0 CTNNB1 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.043 0.051 -9999.0 0.0 -0.156 6.0 6.0 AQP5 -0.023 0.075 0.209 1.0 -0.39 1.0 2.0 CTNND1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.045 0.068 0.172 3.0 -9999.0 0.0 3.0 regulation of calcium-dependent cell-cell adhesion -0.041 0.072 0.19 3.0 -9999.0 0.0 3.0 EGF -0.025 0.132 -9999.0 0.0 -0.295 21.0 21.0 NCKAP1 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.038 0.091 -9999.0 0.0 -0.316 6.0 6.0 cortical microtubule organization -0.0 0.094 -9999.0 0.0 -0.146 32.0 32.0 GO:0000145 -0.043 0.064 0.161 3.0 -9999.0 0.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.004 0.098 -9999.0 0.0 -0.148 32.0 32.0 MLLT4 0.02 0.044 -9999.0 0.0 -0.295 2.0 2.0 ARF6/GDP -0.054 0.053 -9999.0 0.0 -0.14 28.0 28.0 ARF6 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.063 0.045 -9999.0 0.0 -0.151 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.033 0.061 0.163 2.0 -9999.0 0.0 2.0 PVRL2 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.043 0.065 0.167 2.0 -9999.0 0.0 2.0 ARF6/GTP 0.068 0.047 -9999.0 0.0 -0.143 3.0 3.0 CDH1 -0.063 0.147 -9999.0 0.0 -0.295 32.0 32.0 EGFR/EGFR/EGF/EGF -0.038 0.112 -9999.0 0.0 -0.17 42.0 42.0 RhoA/GDP 0.002 0.093 -9999.0 0.0 -0.142 32.0 32.0 actin cytoskeleton organization -0.049 0.072 0.157 3.0 -0.152 30.0 33.0 IGF-1R heterotetramer 0.027 0.031 -9999.0 0.0 -0.295 1.0 1.0 GIT1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.031 -9999.0 0.0 -0.295 1.0 1.0 IGF1 0.008 0.085 -9999.0 0.0 -0.295 8.0 8.0 DIAPH1 -0.026 0.214 -9999.0 0.0 -0.584 11.0 11.0 Wnt receptor signaling pathway 0.0 0.094 0.146 32.0 -9999.0 0.0 32.0 RHOA 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.055 0.053 -9999.0 0.0 -0.141 28.0 28.0 CTNNA1 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.05 0.073 0.158 3.0 -0.155 30.0 33.0 EFNA1 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.048 0.067 0.167 3.0 -9999.0 0.0 3.0 Ephrin A1/EPHA2 -0.006 0.087 -9999.0 0.0 -0.142 31.0 31.0 SEC6/SEC8 -0.049 0.057 -9999.0 0.0 -0.14 30.0 30.0 MGAT3 -0.041 0.072 0.191 3.0 -9999.0 0.0 3.0 HGF/MET -0.022 0.103 -9999.0 0.0 -0.163 35.0 35.0 HGF 0.014 0.069 -9999.0 0.0 -0.295 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.034 0.092 -9999.0 0.0 -0.178 32.0 32.0 actin cable formation -0.02 0.098 0.28 4.0 -0.249 4.0 8.0 KIAA1543 -0.043 0.065 0.163 3.0 -9999.0 0.0 3.0 KIFC3 -0.05 0.062 0.174 1.0 -0.144 31.0 32.0 NCK1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.045 0.069 0.173 3.0 -0.144 30.0 33.0 NCK1/GIT1 0.042 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.0 0.094 -9999.0 0.0 -0.146 32.0 32.0 EXOC4 0.026 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.046 0.069 0.173 3.0 -0.144 31.0 34.0 PIP5K1C -0.045 0.069 0.173 3.0 -0.144 30.0 33.0 LIMA1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.032 -9999.0 0.0 -0.295 1.0 1.0 ROCK1 -0.04 0.084 0.307 2.0 -9999.0 0.0 2.0 adherens junction assembly -0.044 0.081 0.21 2.0 -0.329 3.0 5.0 IGF-1R heterotetramer/IGF1 -0.015 0.099 -9999.0 0.0 -0.151 37.0 37.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.034 0.036 -9999.0 0.0 -0.205 2.0 2.0 MET 0.003 0.09 -9999.0 0.0 -0.295 9.0 9.0 PLEKHA7 -0.045 0.069 0.173 3.0 -9999.0 0.0 3.0 mol:GTP 0.061 0.044 -9999.0 0.0 -0.15 3.0 3.0 establishment of epithelial cell apical/basal polarity -0.017 0.104 0.221 6.0 -9999.0 0.0 6.0 cortical actin cytoskeleton stabilization -0.035 0.092 -9999.0 0.0 -0.176 33.0 33.0 regulation of cell-cell adhesion -0.049 0.072 0.157 3.0 -0.152 30.0 33.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.034 0.092 -9999.0 0.0 -0.178 32.0 32.0