Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events mediated by Stem cell factor receptor (c-Kit)	20.0	1579.0	78.0	-0.258	0.083	1000.0	-1000.0	-0.039	-1000.0
Ephrin A  reverse signaling	19.0	135.0	7.0	-0.027	0.0	1000.0	-1000.0	0.0	-1000.0
E-cadherin signaling events	19.0	98.0	5.0	-0.063	0.03	1000.0	-1000.0	0.022	-1000.0
IL4-mediated signaling events	17.0	1552.0	91.0	-0.494	0.401	1000.0	-1000.0	-0.075	-1000.0
TCR signaling in naïve CD8+ T cells	17.0	1663.0	93.0	-0.221	0.163	1000.0	-1000.0	-0.028	-1000.0
IL23-mediated signaling events	17.0	1035.0	60.0	-0.326	0.03	1000.0	-1000.0	-0.063	-1000.0
E-cadherin signaling in the nascent adherens junction	16.0	1221.0	76.0	-0.116	0.046	1000.0	-1000.0	-0.032	-1000.0
Signaling events regulated by Ret tyrosine kinase	15.0	1301.0	82.0	-0.057	0.031	1000.0	-1000.0	-0.025	-1000.0
IL12-mediated signaling events	13.0	1181.0	87.0	-0.286	0.071	1000.0	-1000.0	-0.039	-1000.0
Endothelins	13.0	1282.0	96.0	-0.127	0.068	1000.0	-1000.0	-0.021	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	13.0	890.0	68.0	-0.267	0.074	1000.0	-1000.0	-0.035	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	13.0	962.0	74.0	-0.063	0.068	1000.0	-1000.0	-0.049	-1000.0
BCR signaling pathway	12.0	1279.0	99.0	-0.157	0.039	1000.0	-1000.0	-0.037	-1000.0
E-cadherin signaling in keratinocytes	12.0	550.0	43.0	-0.069	0.032	1000.0	-1000.0	-0.01	-1000.0
Noncanonical Wnt signaling pathway	11.0	293.0	26.0	-0.042	0.029	1000.0	-1000.0	-0.014	-1000.0
Angiopoietin receptor Tie2-mediated signaling	11.0	1015.0	88.0	-0.167	0.042	1000.0	-1000.0	-0.048	-1000.0
EPHB forward signaling	10.0	927.0	85.0	-0.051	0.05	1000.0	-1000.0	-0.037	-1000.0
Wnt signaling	10.0	73.0	7.0	-0.033	0.026	1000.0	-1000.0	0.004	-1000.0
S1P4 pathway	10.0	252.0	25.0	-0.042	0.036	1000.0	-1000.0	-0.011	-1000.0
Syndecan-1-mediated signaling events	9.0	313.0	34.0	-0.037	0.031	1000.0	-1000.0	-0.015	-1000.0
Thromboxane A2 receptor signaling	9.0	976.0	105.0	-0.075	0.036	1000.0	-1000.0	-0.023	-1000.0
p75(NTR)-mediated signaling	9.0	1133.0	125.0	-0.051	0.077	1000.0	-1000.0	-0.036	-1000.0
Glypican 1 network	9.0	449.0	48.0	-0.037	0.048	1000.0	-1000.0	-0.022	-1000.0
Nectin adhesion pathway	9.0	609.0	63.0	-0.074	0.046	1000.0	-1000.0	-0.028	-1000.0
Ephrin B reverse signaling	9.0	471.0	48.0	-0.08	0.04	1000.0	-1000.0	-0.035	-1000.0
FAS signaling pathway (CD95)	9.0	440.0	47.0	-0.042	0.039	1000.0	-1000.0	-0.022	-1000.0
Integrins in angiogenesis	9.0	825.0	84.0	-0.102	0.059	1000.0	-1000.0	-0.019	-1000.0
LPA receptor mediated events	9.0	987.0	102.0	-0.09	0.035	1000.0	-1000.0	-0.057	-1000.0
EGFR-dependent Endothelin signaling events	9.0	202.0	21.0	-0.036	0.041	1000.0	-1000.0	-0.026	-1000.0
Caspase cascade in apoptosis	8.0	624.0	74.0	-0.062	0.045	1000.0	-1000.0	-0.03	-1000.0
Glucocorticoid receptor regulatory network	8.0	964.0	114.0	-0.224	0.112	1000.0	-1000.0	-0.035	-1000.0
Calcium signaling in the CD4+ TCR pathway	8.0	251.0	31.0	-0.073	0.03	1000.0	-1000.0	-0.024	-1000.0
Osteopontin-mediated events	7.0	294.0	38.0	-0.048	0.038	1000.0	-1000.0	-0.016	-1000.0
JNK signaling in the CD4+ TCR pathway	7.0	133.0	17.0	-0.068	0.038	1000.0	-1000.0	-0.013	-1000.0
HIF-1-alpha transcription factor network	7.0	536.0	76.0	-0.015	0.078	1000.0	-1000.0	-0.009	-1000.0
Arf6 signaling events	7.0	479.0	62.0	-0.036	0.063	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by PTP1B	7.0	536.0	76.0	-0.066	0.047	1000.0	-1000.0	-0.02	-1000.0
BMP receptor signaling	7.0	581.0	81.0	-0.049	0.052	1000.0	-1000.0	-0.009	-1000.0
Fc-epsilon receptor I signaling in mast cells	7.0	766.0	97.0	-0.05	0.051	1000.0	-1000.0	-0.035	-1000.0
amb2 Integrin signaling	7.0	614.0	82.0	-0.047	0.05	1000.0	-1000.0	-0.012	-1000.0
Ceramide signaling pathway	7.0	602.0	76.0	-0.043	0.061	1000.0	-1000.0	-0.015	-1000.0
S1P5 pathway	7.0	122.0	17.0	-0.03	0.035	1000.0	-1000.0	-0.006	-1000.0
IL2 signaling events mediated by PI3K	7.0	435.0	58.0	-0.088	0.04	1000.0	-1000.0	-0.032	-1000.0
Signaling mediated by p38-alpha and p38-beta	7.0	311.0	44.0	-0.055	0.039	1000.0	-1000.0	-0.005	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	7.0	316.0	45.0	-0.05	0.057	1000.0	-1000.0	-0.027	-1000.0
Effects of Botulinum toxin	7.0	200.0	26.0	-0.025	0.045	1000.0	-1000.0	-0.001	-1000.0
Glypican 2 network	7.0	31.0	4.0	0.016	0.021	1000.0	-1000.0	0.024	-1000.0
TCGA08_retinoblastoma	7.0	60.0	8.0	-0.008	0.039	1000.0	-1000.0	-0.005	-1000.0
Plasma membrane estrogen receptor signaling	7.0	622.0	86.0	-0.13	0.07	1000.0	-1000.0	-0.029	-1000.0
Class IB PI3K non-lipid kinase events	7.0	21.0	3.0	-0.011	0.011	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by the Hedgehog family	6.0	352.0	52.0	-0.033	0.041	1000.0	-1000.0	-0.022	-1000.0
a4b1 and a4b7 Integrin signaling	6.0	32.0	5.0	0.008	0.026	1000.0	-1000.0	0.021	-1000.0
Reelin signaling pathway	6.0	368.0	56.0	-0.016	0.062	1000.0	-1000.0	-0.014	-1000.0
TRAIL signaling pathway	6.0	320.0	48.0	-0.023	0.051	1000.0	-1000.0	-0.018	-1000.0
ceramide signaling pathway	6.0	300.0	49.0	-0.028	0.044	1000.0	-1000.0	-0.026	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	6.0	354.0	52.0	-0.071	0.069	1000.0	-1000.0	-0.026	-1000.0
IL27-mediated signaling events	6.0	348.0	51.0	-0.165	0.08	1000.0	-1000.0	-0.042	-1000.0
Class I PI3K signaling events	6.0	467.0	73.0	-0.114	0.053	1000.0	-1000.0	-0.02	-1000.0
Syndecan-4-mediated signaling events	6.0	445.0	67.0	-0.031	0.042	1000.0	-1000.0	-0.026	-1000.0
Ras signaling in the CD4+ TCR pathway	6.0	114.0	17.0	-0.029	0.055	1000.0	-1000.0	-0.019	-1000.0
LPA4-mediated signaling events	5.0	65.0	12.0	-0.048	0.007	1000.0	-1000.0	-0.017	-1000.0
Syndecan-2-mediated signaling events	5.0	393.0	69.0	-0.025	0.046	1000.0	-1000.0	-0.026	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	5.0	505.0	85.0	-0.025	0.047	1000.0	-1000.0	-0.032	-1000.0
EPO signaling pathway	5.0	311.0	55.0	-0.0	0.045	1000.0	-1000.0	-0.013	-1000.0
IFN-gamma pathway	5.0	345.0	68.0	-0.032	0.047	1000.0	-1000.0	-0.034	-1000.0
S1P1 pathway	5.0	197.0	36.0	-0.058	0.03	1000.0	-1000.0	-0.015	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	89.0	15.0	-0.016	0.03	1000.0	-1000.0	-0.02	-1000.0
Regulation of p38-alpha and p38-beta	5.0	306.0	54.0	-0.065	0.057	1000.0	-1000.0	-0.029	-1000.0
IL2 signaling events mediated by STAT5	5.0	110.0	22.0	-0.038	0.03	1000.0	-1000.0	-0.015	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	5.0	609.0	120.0	-0.058	0.073	1000.0	-1000.0	-0.041	-1000.0
PDGFR-beta signaling pathway	5.0	517.0	97.0	-0.078	0.068	1000.0	-1000.0	-0.033	-1000.0
Regulation of Androgen receptor activity	5.0	373.0	70.0	-0.11	0.039	1000.0	-1000.0	-0.024	-1000.0
ErbB2/ErbB3 signaling events	4.0	299.0	65.0	-0.027	0.042	1000.0	-1000.0	-0.053	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	4.0	231.0	54.0	-0.023	0.042	1000.0	-1000.0	-0.015	-1000.0
FOXA2 and FOXA3 transcription factor networks	4.0	200.0	46.0	-0.224	0.035	1000.0	-1000.0	-0.053	-1000.0
IL1-mediated signaling events	4.0	295.0	62.0	-0.009	0.076	1000.0	-1000.0	-0.017	-1000.0
IGF1 pathway	4.0	274.0	57.0	-0.027	0.063	1000.0	-1000.0	-0.024	-1000.0
S1P3 pathway	4.0	184.0	42.0	-0.03	0.046	1000.0	-1000.0	-0.025	-1000.0
Rapid glucocorticoid signaling	4.0	84.0	20.0	-0.008	0.032	1000.0	-1000.0	-0.0	-1000.0
Visual signal transduction: Rods	4.0	223.0	52.0	-0.0	0.05	1000.0	-1000.0	-0.013	-1000.0
Aurora B signaling	4.0	285.0	67.0	-0.105	0.057	1000.0	-1000.0	-0.029	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	516.0	136.0	-0.288	0.08	1000.0	-1000.0	-0.034	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	3.0	113.0	34.0	-0.044	0.075	1000.0	-1000.0	-0.032	-1000.0
Sphingosine 1-phosphate (S1P) pathway	3.0	111.0	28.0	-0.03	0.043	1000.0	-1000.0	-0.009	-1000.0
Visual signal transduction: Cones	3.0	126.0	38.0	-0.013	0.052	1000.0	-1000.0	-0.003	-1000.0
Cellular roles of Anthrax toxin	3.0	150.0	39.0	-0.03	0.032	1000.0	-1000.0	-0.015	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	202.0	65.0	-0.051	0.072	1000.0	-1000.0	-0.026	-1000.0
Presenilin action in Notch and Wnt signaling	3.0	206.0	61.0	-0.011	0.077	1000.0	-1000.0	-0.036	-1000.0
PDGFR-alpha signaling pathway	3.0	161.0	44.0	-0.022	0.06	1000.0	-1000.0	-0.024	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	3.0	126.0	37.0	-0.023	0.055	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by HDAC Class III	3.0	134.0	40.0	-0.055	0.049	1000.0	-1000.0	-0.038	-1000.0
HIF-2-alpha transcription factor network	3.0	138.0	43.0	-0.107	0.11	1000.0	-1000.0	-0.035	-1000.0
TCGA08_p53	3.0	22.0	7.0	-0.004	0.027	1000.0	-1000.0	-0.003	-1000.0
Retinoic acid receptors-mediated signaling	3.0	174.0	58.0	-0.041	0.057	1000.0	-1000.0	-0.021	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	131.0	36.0	-0.045	0.05	1000.0	-1000.0	-0.031	-1000.0
Atypical NF-kappaB pathway	3.0	95.0	31.0	-0.014	0.038	1000.0	-1000.0	-0.002	-1000.0
Canonical Wnt signaling pathway	3.0	193.0	51.0	-0.002	0.062	1000.0	-1000.0	-0.036	-1000.0
Nongenotropic Androgen signaling	3.0	197.0	52.0	-0.052	0.048	1000.0	-1000.0	-0.018	-1000.0
TCGA08_rtk_signaling	3.0	81.0	26.0	-0.023	0.066	1000.0	-1000.0	-0.008	-1000.0
IL6-mediated signaling events	3.0	284.0	75.0	-0.032	0.064	1000.0	-1000.0	-0.039	-1000.0
Insulin Pathway	3.0	286.0	74.0	-0.091	0.073	1000.0	-1000.0	-0.026	-1000.0
FOXM1 transcription factor network	3.0	171.0	51.0	-0.041	0.085	1000.0	-1000.0	-0.067	-1000.0
Coregulation of Androgen receptor activity	2.0	181.0	76.0	-0.058	0.05	1000.0	-1000.0	-0.02	-1000.0
ErbB4 signaling events	2.0	173.0	69.0	-0.058	0.067	1000.0	-1000.0	-0.02	-1000.0
PLK2 and PLK4 events	2.0	6.0	3.0	0.008	0.024	1000.0	-1000.0	-0.004	-1000.0
mTOR signaling pathway	2.0	155.0	53.0	-0.036	0.037	1000.0	-1000.0	-0.025	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	214.0	83.0	-0.013	0.057	1000.0	-1000.0	-0.012	-1000.0
FoxO family signaling	2.0	137.0	64.0	-0.191	0.043	1000.0	-1000.0	-0.038	-1000.0
Regulation of Telomerase	2.0	279.0	102.0	-0.087	0.063	1000.0	-1000.0	-0.03	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	79.0	33.0	-0.0	0.067	1000.0	-1000.0	-0.022	-1000.0
Canonical NF-kappaB pathway	1.0	71.0	39.0	-0.01	0.06	1000.0	-1000.0	-0.013	-1000.0
BARD1 signaling events	1.0	84.0	57.0	-0.06	0.068	1000.0	-1000.0	-0.04	-1000.0
Aurora A signaling	1.0	87.0	60.0	-0.017	0.066	1000.0	-1000.0	-0.008	-1000.0
Arf6 downstream pathway	1.0	80.0	43.0	-0.048	0.054	1000.0	-1000.0	-0.033	-1000.0
Aurora C signaling	1.0	13.0	7.0	0.0	0.042	1000.0	-1000.0	-0.005	-1000.0
PLK1 signaling events	1.0	157.0	85.0	-0.011	0.054	1000.0	-1000.0	-0.019	-1000.0
Insulin-mediated glucose transport	1.0	32.0	32.0	-0.027	0.052	1000.0	-1000.0	-0.019	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	103.0	68.0	-0.04	0.053	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by HDAC Class I	1.0	158.0	104.0	-0.056	0.072	1000.0	-1000.0	-0.04	-1000.0
Syndecan-3-mediated signaling events	1.0	55.0	35.0	0.0	0.077	1000.0	-1000.0	-0.011	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	148.0	125.0	-0.018	0.075	1000.0	-1000.0	-0.019	-1000.0
Arf6 trafficking events	1.0	93.0	71.0	-0.045	0.054	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by PRL	1.0	63.0	34.0	-0.03	0.051	1000.0	-1000.0	-0.031	-1000.0
p38 MAPK signaling pathway	1.0	87.0	44.0	-0.038	0.052	1000.0	-1000.0	-0.01	-1000.0
Arf1 pathway	1.0	55.0	54.0	-0.002	0.046	1000.0	-1000.0	-0.007	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	4.0	23.0	0.005	0.06	1000.0	-1000.0	-0.008	-1000.0
Signaling events mediated by HDAC Class II	0.0	59.0	75.0	-0.031	0.078	1000.0	-1000.0	-0.018	-1000.0
Circadian rhythm pathway	0.0	20.0	22.0	-0.007	0.049	1000.0	-1000.0	-0.028	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	-0.011	0.072	1000.0	-1000.0	-0.022	-1000.0
VEGFR1 specific signals	0.0	54.0	56.0	-0.023	0.065	1000.0	-1000.0	-0.024	-1000.0
Alternative NF-kappaB pathway	0.0	3.0	13.0	0.0	0.073	1000.0	-1000.0	0.0	-1000.0
Total	758	47455	7203	-8.08381344006	7.23117036402	131000	-131000	-2.98609533412	-131000