Clinical Features Time to Death AGE PRIMARY.SITE.OF.DISEASE GENDER DISTANT.METASTASIS LYMPH.NODE.METASTASIS TUMOR.STAGECODE NEOPLASM.DISEASESTAGE nMutated (%) nWild-Type logrank test_P logrank test_Q t-test_P t-test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Chi-square test_P Chi-square test_Q Chi-square test_P Chi-square test_Q t-test_P t-test_Q Chi-square test_P Chi-square test_Q CDKN2A 23 (17%) 114 0.58464 1 0.78111 1 0.42039 1 0.62944 1 0.90021 1 0.62546 1 NA NA 0.7492 1 TP53 23 (17%) 114 0.46431 1 0.012886 1 1 1 1 1 0.91835 1 0.080004 1 NA NA 0.22309 1 BRAF 73 (53%) 64 0.68347 1 0.127 1 0.23168 1 0.59235 1 0.6083 1 0.57517 1 NA NA 0.52092 1 C15ORF23 10 (7%) 127 0.84981 1 0.65225 1 0.6984 1 1 1 0.98184 1 0.62938 1 NA NA 0.60222 1 ERVFRDE1 3 (2%) 134 0.0079091 1 0.68546 1 0.55284 1 0.55067 1 NA NA NA NA NA NA NA NA NRAS 39 (28%) 98 0.84988 1 0.21222 1 0.8232 1 0.84133 1 0.79545 1 0.66026 1 NA NA 0.5228 1 PTEN 12 (9%) 125 0.64166 1 0.21325 1 0.29408 1 0.53647 1 0.044163 1 0.84502 1 NA NA 0.079999 1 PPP6C 14 (10%) 123 0.023153 1 0.72068 1 0.73896 1 1 1 0.078541 1 0.062082 1 NA NA 0.68514 1 PRB4 16 (12%) 121 0.13006 1 0.050634 1 0.11738 1 0.2618 1 0.9558 1 0.14765 1 NA NA 0.90666 1 RAC1 9 (7%) 128 0.49828 1 0.54998 1 1 1 0.71755 1 0.98905 1 0.93507 1 NA NA 0.49886 1 CDH9 23 (17%) 114 0.2013 1 0.1187 1 0.015583 1 0.81232 1 0.89049 1 0.26699 1 NA NA 0.20661 1 STK19 9 (7%) 128 0.52388 1 0.44358 1 1 1 0.4837 1 0.98567 1 0.99606 1 NA NA 0.92722 1 ADH1C 20 (15%) 117 0.44495 1 0.2857 1 0.40692 1 0.45088 1 0.93469 1 0.11679 1 NA NA 0.64233 1 TCEB3C 19 (14%) 118 0.70337 1 0.61138 1 0.77247 1 0.11484 1 0.92674 1 0.47787 1 NA NA 0.29571 1 DDX3X 14 (10%) 123 0.25211 1 0.88017 1 0.31535 1 0.14011 1 0.0091185 1 0.99335 1 NA NA 0.834 1 TRAT1 9 (7%) 128 0.023163 1 0.23173 1 0.4358 1 1 1 0.98567 1 0.01274 1 NA NA 0.91707 1 TTN 108 (79%) 29 0.12437 1 0.8047 1 1 1 0.18464 1 0.25203 1 0.20919 1 NA NA 0.83571 1 GH2 10 (7%) 127 0.57387 1 0.47745 1 0.6984 1 1 1 0.98567 1 0.013645 1 NA NA 0.029428 1 TFEC 13 (9%) 124 0.33708 1 0.20668 1 1 1 0.54275 1 0.96759 1 0.007675 1 NA NA 0.64785 1 IDH1 7 (5%) 130 0.5483 1 0.01244 1 1 1 0.22391 1 0.98905 1 0.98736 1 NA NA 0.58237 1 WDR12 9 (7%) 128 0.88736 1 0.37469 1 1 1 0.27185 1 0.98905 1 0.72743 1 NA NA 0.95145 1 RGS18 7 (5%) 130 0.85325 1 0.33681 1 0.35376 1 0.095012 1 0.99196 1 0.87826 1 NA NA 0.81971 1 POF1B 17 (12%) 120 0.29848 1 0.038786 1 0.54569 1 0.78959 1 0.94218 1 0.16856 1 NA NA 0.94529 1 OR5AC2 16 (12%) 121 0.89717 1 0.81295 1 0.7629 1 1 1 0.94922 1 0.70588 1 NA NA 0.40008 1 VEGFC 13 (9%) 124 0.35752 1 0.87214 1 0.29891 1 1 1 0.96759 1 0.01839 1 NA NA 0.42377 1 RERG 9 (7%) 128 0.71165 1 0.093354 1 0.68486 1 0.71755 1 0.98905 1 0.0077361 1 NA NA 0.51938 1 CCNE2 10 (7%) 127 0.023706 1 0.87546 1 0.11628 1 0.73205 1 0.97755 1 0.88662 1 NA NA 0.49191 1 GPR141 12 (9%) 125 0.66315 1 0.99645 1 0.47445 1 0.75051 1 0.96759 1 0.077478 1 NA NA 0.39345 1 GK2 17 (12%) 120 0.33631 1 0.60342 1 0.22811 1 0.78959 1 0.94922 1 0.1169 1 NA NA 0.2595 1 NAP1L2 12 (9%) 125 0.82676 1 0.033031 1 0.73186 1 0.75051 1 0.96759 1 0.052258 1 NA NA 0.72419 1 SNAP91 18 (13%) 119 0.87749 1 0.2039 1 0.56492 1 0.11714 1 0.60744 1 0.47014 1 NA NA 0.58687 1 PRB2 20 (15%) 117 0.7505 1 0.0062254 1 0.043599 1 0.073228 1 0.92674 1 0.36121 1 NA NA 0.40732 1 TLL1 27 (20%) 110 0.9498 1 0.1247 1 0.12785 1 0.18131 1 0.84727 1 0.094453 1 NA NA 0.12221 1 HBD 8 (6%) 129 0.19556 1 0.80898 1 0.19757 1 1 1 0.98567 1 0.97957 1 NA NA 0.44114 1 GRXCR2 11 (8%) 126 0.3703 1 0.6944 1 1 1 0.75051 1 0.98184 1 0.034082 1 NA NA 0.55438 1 NOTCH2NL 9 (7%) 128 0.92383 1 0.83825 1 0.21297 1 0.71755 1 0.98567 1 0.35231 1 NA NA 0.44166 1 OXA1L 4 (3%) 133 0.50868 1 0.15069 1 0.57286 1 1 1 0.99644 1 5.1678e-05 0.0258 NA NA 0.29362 1 AREG 6 (4%) 131 0.49223 1 0.29295 1 1 1 0.40312 1 0.99443 1 0.0021451 1 NA NA 0.52685 1 HBG2 6 (4%) 131 0.25159 1 0.33623 1 0.62402 1 1 1 0.99196 1 0.0069035 1 NA NA 0.45416 1 SERPINB4 20 (15%) 117 0.82732 1 0.28315 1 0.40692 1 0.019473 1 0.20128 1 0.37137 1 NA NA 0.93938 1 SPTLC3 14 (10%) 123 0.30314 1 0.71291 1 0.18753 1 0.77306 1 0.9558 1 0.14765 1 NA NA 0.23155 1 TAF1A 9 (7%) 128 0.024037 1 0.8842 1 0.68486 1 0.4837 1 0.22159 1 0.73676 1 NA NA 0.79799 1 CLVS2 13 (9%) 124 0.66615 1 0.22349 1 0.73229 1 0.21838 1 0.96759 1 0.079433 1 NA NA 0.80623 1 CCDC102B 15 (11%) 122 0.79443 1 0.48627 1 0.75064 1 0.77306 1 0.96192 1 0.11547 1 NA NA 0.81416 1 OR4N2 15 (11%) 122 0.85905 1 0.24734 1 0.75064 1 0.020005 1 0.060423 1 0.2603 1 NA NA 0.8142 1 OR8D4 9 (7%) 128 0.03949 1 0.62005 1 0.68486 1 1 1 0.98567 1 0.036623 1 NA NA 0.97966 1 RBM11 10 (7%) 127 0.83649 1 0.01469 1 0.4522 1 0.49483 1 0.97755 1 0.038118 1 NA NA 0.43366 1 DEFB118 7 (5%) 130 0.10722 1 0.64036 1 1 1 1 1 0.98905 1 0.027452 1 NA NA 0.78126 1 GRXCR1 13 (9%) 124 0.33232 1 0.016815 1 0.29891 1 1 1 0.96759 1 0.84502 1 NA NA 0.50552 1 RGPD3 22 (16%) 115 0.98091 1 0.0058431 1 0.78351 1 0.04651 1 0.70501 1 0.24461 1 NA NA 0.86282 1 CA1 8 (6%) 129 0.85051 1 0.88114 1 1 1 0.26701 1 0.99196 1 0.89083 1 NA NA 0.9361 1 HNF4G 15 (11%) 122 0.048688 1 0.11445 1 1 1 0.385 1 0.9558 1 0.012016 1 NA NA 0.77404 1 ACTL7B 8 (6%) 129 0.35186 1 0.59527 1 0.68062 1 1 1 0.99443 1 9.9816e-08 5e-05 NA NA 0.095267 1 SPAG16 12 (9%) 125 0.65813 1 0.7063 1 1 1 0.33688 1 0.97755 1 0.07586 1 NA NA 0.84245 1 PCDHB8 23 (17%) 114 0.55942 1 0.49785 1 0.78832 1 0.23136 1 0.92674 1 0.37747 1 NA NA 0.57621 1 HIST1H2AA 5 (4%) 132 0.56742 1 0.82164 1 0.59052 1 1 1 0.99443 1 0.96319 1 NA NA 0.97331 1 OR10K2 14 (10%) 123 0.14849 1 0.0061043 1 0.73896 1 0.14011 1 0.96759 1 0.17398 1 NA NA 0.58962 1 PHGDH 8 (6%) 129 0.72153 1 0.69154 1 0.68062 1 0.051405 1 0.99196 1 0.0074165 1 NA NA 0.11647 1 OR9K2 11 (8%) 126 0.60377 1 0.075312 1 0.067032 1 0.33423 1 0.9728 1 0.09518 1 NA NA 0.68426 1 LIN7A 8 (6%) 129 0.8754 1 0.71647 1 0.19757 1 0.71755 1 0.99196 1 0.0089691 1 NA NA 0.85832 1 USP17L2 13 (9%) 124 0.75134 1 0.54939 1 0.18207 1 0.21838 1 0.96759 1 0.12312 1 NA NA 0.25085 1 ANKRD20A4 4 (3%) 133 0.4715 1 0.52881 1 0.57286 1 0.30029 1 0.99644 1 0.00013877 0.0691 NA NA 0.62658 1 CYLC2 14 (10%) 123 0.4683 1 0.1711 1 0.51983 1 0.14011 1 0.96759 1 0.048799 1 NA NA 0.73463 1 VGLL1 5 (4%) 132 0.98346 1 0.22911 1 0.33204 1 0.16791 1 0.99644 1 3.7469e-05 0.0187 NA NA 0.92921 1 DEFB110 5 (4%) 132 0.11986 1 0.99424 1 0.59052 1 0.16791 1 0.99443 1 0.00064599 0.32 NA NA 0.67123 1 LCE1B 7 (5%) 130 0.048431 1 0.73403 1 0.66516 1 1 1 0.99196 1 0.92796 1 NA NA 0.864 1 PARM1 10 (7%) 127 0.228 1 0.48839 1 0.6984 1 0.49483 1 0.98184 1 0.026744 1 NA NA 0.085769 1 ACSM2B 24 (18%) 113 0.40576 1 0.52856 1 0.19542 1 0.0036787 1 0.89049 1 0.41297 1 NA NA 0.97059 1 BAGE2 7 (5%) 130 0.73749 1 0.23722 1 0.1996 1 0.68705 1 0.00050512 0.251 0.0024714 1 NA NA 0.20659 1 CECR6 6 (4%) 131 0.33765 1 0.95313 1 1 1 1 1 0.99196 1 0.57705 1 NA NA 0.55287 1 OR4M2 15 (11%) 122 0.77368 1 0.000531 0.263 0.51984 1 0.77306 1 0.9558 1 0.34843 1 NA NA 0.22809 1 CERKL 10 (7%) 127 0.62023 1 0.98066 1 0.6984 1 1 1 0.98184 1 0.054695 1 NA NA 0.85761 1