Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
CDKN2A	23 (17%)	114	0.40104	1	0.29679	1	0.27492	1	0.2525	1	0.77284	1	0.7972	1	0.87403	1	0.94229	1
TP53	23 (17%)	114	0.22297	1	0.03719	1	0.38184	1	0.535	1	0.074151	1	0.059379	1	0.015373	1	0.13689	1
BRAF	73 (53%)	64	0.059262	1	0.1891	1	0.57781	1	0.041096	1	0.41	1	0.18618	1	0.012644	1	0.45045	1
C15ORF23	10 (7%)	127	0.40048	1	0.066625	1	0.72211	1	1	1	0.84423	1	1	1	1	1	0.88412	1
ERVFRDE1	3 (2%)	134	1	1	0.49043	1	NA	NA	NA	NA	1	1	1	1	0.79856	1	1	1
NRAS	39 (28%)	98	0.0033296	1	0.074811	1	0.53269	1	0.15047	1	0.67891	1	0.72792	1	0.39261	1	0.72304	1
PTEN	12 (9%)	125	0.51636	1	0.23615	1	0.152	1	0.37503	1	0.74757	1	0.27598	1	0.5037	1	0.82041	1
PPP6C	14 (10%)	123	0.0080061	1	0.67905	1	0.75254	1	0.49808	1	0.72634	1	1	1	0.1306	1	0.40973	1
PRB4	16 (12%)	121	0.86745	1	0.83972	1	0.020069	1	0.091178	1	0.25897	1	0.32988	1	0.5824	1	0.4082	1
RAC1	9 (7%)	128	0.77673	1	1	1	1	1	1	1	1	1	0.67253	1	0.82295	1	0.048337	1
CDH9	23 (17%)	114	0.92157	1	0.45852	1	0.74155	1	0.96378	1	0.80748	1	1	1	0.021613	1	0.8916	1
STK19	9 (7%)	128	0.77673	1	0.096855	1	0.53795	1	0.65943	1	0.20199	1	0.32959	1	0.13624	1	0.68601	1
ADH1C	20 (15%)	117	0.11321	1	0.43867	1	0.09409	1	0.066776	1	0.12281	1	0.39695	1	0.05936	1	0.36684	1
TCEB3C	19 (14%)	118	0.85713	1	0.32784	1	0.55179	1	0.93892	1	0.40747	1	0.47733	1	0.81507	1	0.5037	1
DDX3X	14 (10%)	123	0.20435	1	0.72648	1	0.31702	1	0.10611	1	0.30668	1	0.57461	1	0.54234	1	0.10954	1
TRAT1	9 (7%)	128	0.68736	1	0.82908	1	1	1	1	1	0.57019	1	0.747	1	0.61163	1	0.68601	1
TTN	108 (79%)	29	0.492	1	0.35035	1	0.22869	1	0.11366	1	0.92695	1	0.72696	1	0.28561	1	0.64358	1
GH2	10 (7%)	127	0.093835	1	0.91865	1	0.39839	1	0.65296	1	0.35103	1	0.63673	1	0.58297	1	0.78849	1
TFEC	13 (9%)	124	0.87458	1	0.62276	1	0.24719	1	0.49887	1	1	1	0.56123	1	0.52436	1	0.32161	1
IDH1	7 (5%)	130	0.66613	1	0.79477	1	0.56845	1	0.52655	1	0.3318	1	0.41951	1	0.038129	1	0.15004	1
WDR12	9 (7%)	128	1	1	1	1	1	1	0.77811	1	0.68238	1	0.083712	1	0.018247	1	0.037277	1
RGS18	7 (5%)	130	0.66613	1	1	1	0.53828	1	0.42622	1	0.79435	1	0.78025	1	0.21496	1	0.73097	1
POF1B	17 (12%)	120	0.089334	1	0.14454	1	0.44265	1	0.62721	1	0.43576	1	0.89222	1	0.5342	1	0.46747	1
OR5AC2	16 (12%)	121	0.77735	1	0.70999	1	0.2042	1	0.94318	1	0.44406	1	0.29072	1	0.88809	1	1	1
VEGFC	13 (9%)	124	0.3964	1	0.46553	1	0.8168	1	0.0054431	1	0.029882	1	0.012023	1	0.063688	1	0.049505	1
RERG	9 (7%)	128	0.56825	1	0.68284	1	0.12537	1	0.067045	1	0.51915	1	0.23967	1	0.13624	1	0.38605	1
CCNE2	10 (7%)	127	0.50612	1	0.64991	1	0.25821	1	0.13588	1	0.84423	1	0.76255	1	0.022865	1	0.56053	1
GPR141	12 (9%)	125	0.55681	1	0.012483	1	0.0013349	0.761	0.0072441	1	0.5522	1	0.41914	1	0.22089	1	0.6596	1
GK2	17 (12%)	120	0.41295	1	0.75967	1	0.74682	1	1	1	0.84733	1	0.41144	1	0.50179	1	0.8041	1
NAP1L2	12 (9%)	125	0.64475	1	0.34996	1	0.72211	1	0.15669	1	0.59308	1	0.7905	1	0.54427	1	1	1
SNAP91	18 (13%)	119	0.70342	1	0.56585	1	0.86888	1	0.62213	1	0.62503	1	0.48774	1	0.89809	1	0.33099	1
PRB2	20 (15%)	117	0.38592	1	0.95323	1	0.6609	1	1	1	0.049201	1	0.18828	1	0.0014542	0.827	0.026843	1
TLL1	27 (20%)	110	0.76616	1	0.31614	1	0.76487	1	0.17876	1	0.093836	1	0.045879	1	0.40013	1	0.40695	1
HBD	8 (6%)	129	0.49877	1	0.73263	1	1	1	0.15799	1	0.21302	1	0.061223	1	0.072138	1	0.14312	1
GRXCR2	11 (8%)	126	0.84631	1	1	1	0.37133	1	0.71948	1	0.62384	1	0.46671	1	0.61118	1	0.80135	1
NOTCH2NL	9 (7%)	128	0.20979	1	0.56868	1	0.19441	1	0.10744	1	0.04087	1	0.2987	1	0.55331	1	0.037277	1
OXA1L	4 (3%)	133	0.68544	1	0.18324	1	NA	NA	NA	NA	0.82662	1	0.54516	1	0.83464	1	0.43963	1
AREG	6 (4%)	131	0.71721	1	0.37999	1	0.83234	1	0.68939	1	0.87905	1	0.48951	1	1	1	0.6939	1
HBG2	6 (4%)	131	0.29424	1	0.37999	1	NA	NA	NA	NA	1	1	1	1	0.50358	1	0.56197	1
SERPINB4	20 (15%)	117	0.48736	1	0.75025	1	0.015396	1	0.018278	1	0.48294	1	0.39695	1	0.95108	1	0.48619	1
SPTLC3	14 (10%)	123	1	1	0.63772	1	0.41814	1	0.85876	1	0.041432	1	0.43906	1	0.23356	1	0.6383	1
TAF1A	9 (7%)	128	0.96361	1	0.91075	1	0.72211	1	0.21191	1	0.34474	1	0.6015	1	0.90801	1	0.45405	1
CLVS2	13 (9%)	124	0.1945	1	0.54152	1	0.60869	1	0.9639	1	0.029882	1	0.18973	1	0.80794	1	0.83081	1
CCDC102B	15 (11%)	122	0.21884	1	0.88937	1	0.14962	1	0.92083	1	0.69452	1	0.5582	1	0.88105	1	0.92003	1
OR4N2	15 (11%)	122	0.031013	1	0.79152	1	0.26974	1	0.62451	1	0.035269	1	0.14215	1	0.15835	1	0.35906	1
OR8D4	9 (7%)	128	0.56825	1	0.82908	1	0.05278	1	0.75551	1	0.51915	1	0.747	1	0.61163	1	0.38605	1
RBM11	10 (7%)	127	0.45005	1	0.91865	1	0.31985	1	0.91726	1	0.65045	1	0.69666	1	0.52316	1	0.49534	1
DEFB118	7 (5%)	130	0.45453	1	0.37381	1	0.53795	1	0.22466	1	0.7055	1	0.31933	1	0.4744	1	0.61253	1
GRXCR1	13 (9%)	124	0.56096	1	0.32863	1	1	1	0.57441	1	0.24748	1	0.8664	1	0.36114	1	0.55878	1
RGPD3	22 (16%)	115	0.34693	1	0.83793	1	0.67198	1	0.76781	1	0.18828	1	0.44577	1	0.54616	1	0.65249	1
CA1	8 (6%)	129	0.20115	1	0.2411	1	0.014929	1	0.41532	1	0.15143	1	0.6366	1	0.059593	1	0.06893	1
HNF4G	15 (11%)	122	0.53257	1	0.28669	1	1	1	0.89405	1	0.93977	1	0.8809	1	0.49533	1	0.16282	1
ACTL7B	8 (6%)	129	0.57393	1	0.59403	1	0.37126	1	0.089182	1	0.47347	1	0.36851	1	0.45987	1	0.49275	1
SPAG16	12 (9%)	125	0.58997	1	0.55128	1	0.78479	1	0.86002	1	0.64234	1	0.4968	1	0.12501	1	0.32663	1
PCDHB8	23 (17%)	114	0.065847	1	0.064593	1	0.26025	1	0.78077	1	0.35424	1	0.22828	1	0.10949	1	0.8916	1
HIST1H2AA	5 (4%)	132	0.40443	1	0.5233	1	0.83234	1	0.57184	1	0.37484	1	0.43398	1	0.63118	1	0.80649	1
OR10K2	14 (10%)	123	1	1	0.93952	1	0.70984	1	0.61091	1	0.67954	1	0.66605	1	0.29278	1	0.31285	1
PHGDH	8 (6%)	129	0.70704	1	0.81244	1	0.60106	1	0.31739	1	0.59351	1	1	1	0.51361	1	0.34795	1
OR9K2	11 (8%)	126	0.37493	1	1	1	0.059173	1	0.090514	1	0.21072	1	0.55022	1	0.23324	1	1	1
LIN7A	8 (6%)	129	0.29682	1	0.051159	1	0.53795	1	0.92393	1	0.24072	1	0.4563	1	0.20109	1	0.8688	1
USP17L2	13 (9%)	124	0.55027	1	0.54152	1	0.36135	1	0.19724	1	0.58076	1	0.41427	1	0.69775	1	0.61596	1
ANKRD20A4	4 (3%)	133	0.55514	1	0.30696	1	0.11733	1	0.046114	1	0.18542	1	0.33989	1	0.43326	1	0.75777	1
CYLC2	14 (10%)	123	0.43341	1	0.82262	1	0.25821	1	0.63096	1	0.10013	1	0.042952	1	0.31648	1	0.28285	1
VGLL1	5 (4%)	132	0.74923	1	0.14909	1	0.83234	1	0.83074	1	0.73529	1	1	1	0.27627	1	0.64258	1
DEFB110	5 (4%)	132	0.69571	1	0.14909	1	0.23708	1	0.12071	1	0.522	1	0.84703	1	0.53511	1	1	1
LCE1B	7 (5%)	130	0.15144	1	1	1	0.87263	1	1	1	0.79435	1	0.78025	1	0.88449	1	0.85787	1
PARM1	10 (7%)	127	0.45005	1	0.5463	1	0.72211	1	0.69785	1	1	1	0.47948	1	0.83721	1	0.88412	1
ACSM2B	24 (18%)	113	0.36866	1	0.51423	1	0.82773	1	0.74407	1	0.21945	1	0.08324	1	0.020944	1	0.31971	1
BAGE2	7 (5%)	130	0.49163	1	0.3324	1	1	1	0.80506	1	0.081371	1	0.78025	1	0.37519	1	0.85787	1
CECR6	6 (4%)	131	0.79167	1	0.17342	1	0.63214	1	0.010217	1	0.28079	1	0.6623	1	0.26229	1	0.84167	1
OR4M2	15 (11%)	122	0.5166	1	0.27053	1	0.57368	1	0.48842	1	1	1	0.63182	1	0.147	1	0.55896	1
CERKL	10 (7%)	127	0.43975	1	0.35007	1	1	1	0.58813	1	1	1	0.43063	1	0.83721	1	0.88412	1