rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BRAF(78), CAMP(1), CREB5(7), MAPK1(3), RAF1(2), SNX13(1), SRC(1) 2251916 93 80 31 23 25 3 2 63 0 0 0.133 6.79e-05 0.0398 2 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CCND1(1), CDK4(2), CDKN1A(2), CDKN1B(1), CDKN2A(23), CFL1(1), E2F1(5), E2F2(3), MDM2(2), NXT1(2), PRB1(18), TP53(26) 1704325 86 52 72 14 40 3 4 10 29 0 2.01e-05 0.000129 0.0398 3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(12), CCND1(1), CCNE1(3), CCNE2(10), CDK4(2), CDKN1B(1), CDKN2A(23), E2F1(5), E2F2(3), PRB1(18) 1815524 78 54 64 13 41 0 4 12 21 0 0.000109 0.000917 0.188 4 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(4), IL8(1), SLPI(5) 346525 10 10 10 2 4 1 0 4 1 0 0.226 0.138 1.000 5 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(3), FOSB(5), GRIA2(22), PPP1R1B(1) 731255 31 25 28 8 22 1 0 4 4 0 0.0327 0.146 1.000 6 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(8) 144360 8 8 8 2 7 1 0 0 0 0 0.171 0.224 1.000 7 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(1), MYC(2), SP1(4), SP3(1), TP53(26), WT1(4) 1428799 38 29 35 5 18 2 5 4 9 0 0.00325 0.224 1.000 8 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3) 1133089 78 50 71 20 59 5 4 8 2 0 0.00130 0.510 1.000 9 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(5), DCN(14), FMOD(3), KERA(13), LUM(7) 704012 42 28 41 13 34 3 2 1 2 0 0.00465 0.636 1.000 10 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(3), ALDH1A2(9), BCMO1(10), RDH5(1) 785999 23 20 22 7 15 2 1 3 2 0 0.0662 0.784 1.000 11 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(4), CHRNA1(3), SNAP25(5), STX1A(2) 659260 14 11 12 3 10 0 0 1 3 0 0.0515 0.817 1.000 12 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 103800 1 1 1 1 1 0 0 0 0 0 0.896 0.876 1.000 13 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(5), ACADS(2), HADHA(7) 1105580 16 14 16 4 10 1 1 4 0 0 0.196 0.906 1.000 14 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(3), CDKN2A(23), E2F1(5), MDM2(2), MYC(2), PIK3CA(2), PIK3R1(2), POLR1A(7), POLR1B(5), POLR1C(1), RAC1(9), RB1(3), TBX2(2), TP53(26), TWIST1(1) 4072150 93 53 76 18 49 3 3 8 28 2 7.29e-05 0.923 1.000 15 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(5), CD3E(2) 226627 7 5 7 3 6 0 0 0 1 0 0.499 0.932 1.000 16 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(2) 334020 2 2 2 1 1 0 0 1 0 0 0.741 0.935 1.000 17 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(2), CASP3(1), CASP8(2), CFL1(1), CFLAR(3), PDE6D(2) 788035 11 9 11 3 4 1 2 4 0 0 0.314 0.938 1.000 18 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(2), ALDOA(1), ALDOB(8), ALDOC(1) 795772 12 9 11 3 8 1 0 1 2 0 0.0981 0.974 1.000 19 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(4), GOT2(2), TAT(12) 530657 18 11 18 6 14 1 2 1 0 0 0.116 0.981 1.000 20 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(3), CDC34(3), CUL1(4), E2F1(5), FBXW7(9), RB1(3), TFDP1(1) 1631923 28 22 28 9 14 2 3 3 4 2 0.200 0.985 1.000 21 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), HADHA(7), HADHB(2), HSD17B10(1), HSD17B4(3), MECR(4), PPT1(3), PPT2(4) 1705533 25 23 25 7 12 2 3 7 1 0 0.168 0.986 1.000 22 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(2) 312382 2 1 2 0 0 1 0 0 1 0 0.527 0.988 1.000 23 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(4), SEC61A2(4), SRP19(4), SRP54(2), SRP68(5), SRP72(1), SRPR(2) 1542050 22 19 20 6 10 0 1 6 5 0 0.322 0.989 1.000 24 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), EHHADH(5), HADHA(7) 974332 13 12 12 5 9 1 0 3 0 0 0.336 0.990 1.000 25 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(3), MTMR2(1), MTMR6(2), NFS1(3), TPK1(3) 1284130 13 12 13 2 10 1 1 0 1 0 0.0952 0.991 1.000 26 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(3), SQLE(2) 640942 5 5 5 2 3 1 0 1 0 0 0.551 0.992 1.000 27 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), EHHADH(5), HADHA(7), HSD17B10(1), HSD17B4(3), NTAN1(1), SIRT2(1), SIRT5(5), SIRT7(2), VNN2(9) 2380431 35 26 34 7 23 3 3 6 0 0 0.0151 0.993 1.000 28 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYB(1), RB1(3), SP1(4), SP3(1) 1342774 10 9 10 3 1 2 1 2 2 2 0.523 0.993 1.000 29 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(1), EHHADH(5), GCDH(3), HADHA(7) 1571520 16 13 15 4 11 2 0 3 0 0 0.133 0.993 1.000 30 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(3), IFNG(2), IL12A(2), IL12B(3), IL18(2), IL2(4) 590656 16 7 16 5 11 2 0 1 2 0 0.153 0.995 1.000 31 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(2), TGDS(1), UXS1(1) 777849 4 4 4 3 1 0 0 0 3 0 0.935 0.996 1.000 32 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(3), RAB11A(1), RAB27A(3), RAB3A(2) 847829 9 7 9 3 7 0 1 1 0 0 0.338 0.996 1.000 33 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(9), COASY(3), DPYD(38), DPYS(15), ENPP1(9), ENPP3(10), PANK2(2), PANK3(1), PANK4(4), PPCS(3), UPB1(5) 2787251 99 53 91 27 74 6 4 7 8 0 0.000808 0.997 1.000 34 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(12), CCND1(1), CCND2(4), CCND3(1), CCNE1(3), CCNH(1), CDC25A(6), CDK4(2), CDK6(1), CDKN1A(2), CDKN1B(1), CDKN2A(23), CDKN2C(1), E2F1(5), RB1(3), RBL1(5), TFDP1(1) 3254316 72 49 62 20 36 3 4 6 21 2 0.00746 0.998 1.000 35 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(3), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(1), PSMB4(1), PSMB5(1), PSMB7(1), PSMB8(2) 1777148 17 14 17 3 10 2 2 1 2 0 0.0766 0.998 1.000 36 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), CBS(5), MUT(4) 1025585 10 10 10 4 8 0 0 1 1 0 0.441 0.999 1.000 37 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(8), LPL(2), NR3C1(2), PPARG(8), RETN(3), RXRA(1), TNF(1) 1173572 25 21 23 8 18 2 0 3 2 0 0.0702 0.999 1.000 38 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(6), GGT1(4), SHMT2(2) 813938 12 11 12 7 9 0 0 2 1 0 0.463 0.999 1.000 39 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(9), BCAT2(1), COASY(3), DPYD(38), DPYS(15), ENPP1(9), ENPP3(10), ILVBL(2), PANK2(2), PANK3(1), PANK4(4), PPCS(3), UPB1(5), VNN1(4) 3457773 106 54 98 29 79 6 4 8 9 0 0.000208 0.999 1.000 40 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(2), TGDS(1), UGP2(1), UXS1(1) 991913 5 5 5 4 2 0 0 0 3 0 0.941 1.000 1.000 41 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(4) 623865 6 6 6 5 3 0 1 1 1 0 0.834 1.000 1.000 42 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), CYCS(1), GPD2(1), SDHA(1), SDHC(2), UQCRC1(3) 1338329 9 9 9 2 6 0 1 1 1 0 0.220 1.000 1.000 43 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(1), HMGCL(2), OXCT1(3) 676623 6 6 6 3 4 0 0 1 1 0 0.667 1.000 1.000 44 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(2), PLCD1(2), PRKCA(8), TGM2(4) 999429 16 10 15 7 12 2 0 0 2 0 0.125 1.000 1.000 45 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(2), IFNG(2), IFNGR1(3), IFNGR2(2), IKBKB(2), JAK2(6), LIN7A(10), NFKB1(3), NFKBIA(2), RB1(3), RELA(2), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TP53(26), USH1C(13), WT1(4) 3626636 84 47 80 22 41 5 5 13 18 2 0.00476 1.000 1.000 46 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(3), NFKBIA(2), PLCB1(33), PRKCA(8), RELA(2) 1643646 49 33 45 18 41 2 1 2 3 0 0.0826 1.000 1.000 47 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(5), ICAM1(2), ITGAL(17), ITGAM(19), ITGB2(10), SELE(22), SELL(6) 2055530 81 40 81 25 62 3 1 5 10 0 0.00102 1.000 1.000 48 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(9), IARS(5), LARS(8), LARS2(3), PDHA1(1), PDHA2(9), PDHB(1) 2028403 36 22 35 8 26 3 0 3 4 0 0.0345 1.000 1.000 49 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCR3(8), CSF2(2), HLA-DRA(7), HLA-DRB1(2), IL3(2), IL5(4) 609236 26 18 25 11 22 1 0 2 1 0 0.0650 1.000 1.000 50 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(1), ERBB4(30), NRG2(5), NRG3(14), PRKCA(8), PSEN1(1) 1787629 59 41 54 17 46 4 2 4 3 0 0.0143 1.000 1.000 51 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(2), GBA3(6), GGT1(4), SHMT2(2) 1074646 15 12 15 7 12 0 0 2 1 0 0.313 1.000 1.000 52 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(3), ATM(10), BAX(1), BCL2(2), CCND1(1), CCNE1(3), CDK4(2), CDKN1A(2), E2F1(5), MDM2(2), PCNA(1), RB1(3), TIMP3(4), TP53(26) 3619700 65 45 61 16 30 5 4 9 15 2 0.0252 1.000 1.000 53 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(2), PAPSS2(4), SULT1A2(2), SULT1E1(10), SULT2A1(4), SUOX(3) 1224048 25 13 24 7 20 0 0 2 3 0 0.0853 1.000 1.000 54 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(3), CDKN1B(1), CUL1(4), E2F1(5), RB1(3), TFDP1(1), UBE2M(1) 1729176 18 17 18 9 8 2 2 2 2 2 0.556 1.000 1.000 55 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(3), ACTR2(2), ARPC1B(2), ARPC2(1), ARPC3(1), RAC1(9), WASF1(1), WASL(3) 1634225 22 18 18 6 18 0 1 1 2 0 0.128 1.000 1.000 56 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(3), IFNGR2(2), JAK1(4), JAK2(6), STAT1(2) 1640410 19 11 19 6 8 0 1 6 4 0 0.499 1.000 1.000 57 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(3), ACP2(2), ACP5(3), ACPP(6), ENPP1(9), ENPP3(10), FLAD1(6), TYR(5) 1940575 44 30 43 13 29 3 2 3 7 0 0.0521 1.000 1.000 58 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(1), DNAJC3(2), EIF2S1(1), MAP3K14(1), NFKB1(3), NFKBIA(2), RELA(2), TP53(26) 1945612 38 30 35 12 22 1 3 3 9 0 0.152 1.000 1.000 59 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(3), BAX(1), BCL2(2), BIK(1), BIRC2(4), BIRC3(6), CASP3(1), CASP7(4), CASP8(2), CASP9(3), CYCS(1), DFFA(1), DFFB(2), DIABLO(1) 2713990 32 24 32 9 19 3 5 4 1 0 0.0914 1.000 1.000 60 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLS2(3), GLUD1(1), GLUD2(1) 913160 6 4 6 6 3 2 0 0 1 0 0.898 1.000 1.000 61 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(12), CCNE1(3), CDC34(3), CUL1(4), E2F1(5), RB1(3), TFDP1(1) 1711009 31 25 31 12 21 2 2 2 2 2 0.194 1.000 1.000 62 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(3), BAX(1), BCL10(1), BCL2(2), BCL2L11(3), CASP8AP2(3), CASP9(3), CES1(12) 2175480 28 18 28 8 22 3 1 0 2 0 0.0979 1.000 1.000 63 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(1), CASP7(4), DFFA(1), DFFB(2), GZMB(2), HMGB1(1), TOP2A(4), TOP2B(4) 1805401 19 14 19 6 13 1 3 1 1 0 0.311 1.000 1.000 64 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(6), CDC25B(3), CDKN1A(2), CHEK1(1), NEK1(7), WEE1(2) 1392434 21 16 21 6 12 4 1 1 3 0 0.256 1.000 1.000 65 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(3), ACP2(2), ACP5(3), ACP6(8), ACPP(6), ENPP1(9), ENPP3(10), FLAD1(6), LHPP(1), MTMR1(3), MTMR2(1), MTMR6(2), TYR(5) 3008696 59 37 58 15 38 4 5 4 8 0 0.0111 1.000 1.000 66 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 CAMP(1), DAG1(3), GNAQ(1), ITPKB(5) 1206635 10 10 10 5 8 0 1 0 1 0 0.414 1.000 1.000 67 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(5), ICAM1(2), ITGA4(26), ITGAL(17), ITGB1(4), ITGB2(10), SELE(22), SELL(6) 2396749 92 46 89 28 71 3 2 7 9 0 0.00549 1.000 1.000 68 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(6), GOT1(4), GOT2(2), LDHA(2), LDHC(3), MPST(2) 1383311 19 15 18 8 15 0 4 0 0 0 0.262 1.000 1.000 69 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(4), CBS(5), GGT1(4), MARS(5), MARS2(3), MAT1A(4), MAT2B(1), PAPSS1(2), PAPSS2(4), SCLY(2), SEPHS1(4) 2505285 38 29 38 11 24 1 2 6 5 0 0.0243 1.000 1.000 70 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(3), CYSLTR2(2), GPR109B(7), GPR161(6), GPR171(6), GPR18(1), GPR39(8), GPR45(5), GPR65(7), GPR68(2), GPR75(4), GPR81(3) 1963085 54 36 53 25 40 3 3 2 6 0 0.00442 1.000 1.000 71 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(5), POLR2A(10), POLR2B(11), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(1) 2684332 34 28 34 10 21 3 2 5 3 0 0.0640 1.000 1.000 72 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(3), GGPS1(1), SQLE(2) 856337 6 6 6 4 4 1 0 1 0 0 0.747 1.000 1.000 73 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(2), BMPR1A(1), BMPR1B(2), BMPR2(4) 1264076 9 9 9 7 7 1 0 0 1 0 0.840 1.000 1.000 74 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(3), ALAS2(2), CPOX(2), FECH(2), HMBS(1), PPOX(2), UROS(1) 1520529 13 11 13 7 10 1 0 0 2 0 0.515 1.000 1.000 75 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(4), CD3D(5), CD3E(2), GZMB(2), HLA-A(2), ICAM1(2), ITGAL(17), ITGB2(10), PRF1(6) 1745521 50 30 49 22 33 5 0 3 9 0 0.0869 1.000 1.000 76 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(3), ACAA2(1), ACAT2(1), EHHADH(5), HADHA(7), HADHB(2) 1682118 19 17 18 8 13 2 0 3 1 0 0.443 1.000 1.000 77 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(6), CASP8(2), RIPK1(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(2) 1645493 16 14 16 7 11 1 1 2 1 0 0.378 1.000 1.000 78 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(3), AASDH(4), AASDHPPT(1), AASS(1), KARS(3) 1385893 12 10 12 6 10 0 0 1 1 0 0.698 1.000 1.000 79 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(10), NR0B2(6), NR1H3(2), NR1H4(10), RXRA(1) 1093704 29 19 29 12 19 6 2 0 2 0 0.0948 1.000 1.000 80 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(12), RANGAP1(2) 1715595 14 14 14 8 10 2 0 0 2 0 0.830 1.000 1.000 81 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(3), CPS1(13), GLS(1), GLUD1(1), GOT1(4) 1528431 23 14 22 10 15 3 2 3 0 0 0.377 1.000 1.000 82 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(4), PARK2(4), SNCAIP(37), UBE2E2(2), UBE2F(4), UBE2L6(1) 1294284 52 35 46 19 42 6 0 3 1 0 0.0978 1.000 1.000 83 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO3(2), FARS2(3), GOT1(4), GOT2(2), PAH(3), TAT(12), YARS(1) 1681127 29 20 29 14 24 2 2 1 0 0 0.177 1.000 1.000 84 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(4), BHMT(6), CBS(5), DNMT1(13), DNMT3A(5), DNMT3B(9), MARS(5), MARS2(3), MAT1A(4), MAT2B(1), MTR(5) 3549624 60 36 59 17 37 3 3 9 8 0 0.00975 1.000 1.000 85 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNG(2), IFNGR1(3), JAK1(4), JAK2(6), PLA2G2A(2), PTPRU(12), REG1A(5), STAT1(2) 2291781 38 23 38 13 22 1 1 8 6 0 0.129 1.000 1.000 86 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(2), GSR(2), GSS(5), IL8(1), NFKB1(3), NOX1(7), RELA(2), TNF(1), XDH(38) 1979405 61 35 61 29 47 4 4 4 2 0 0.111 1.000 1.000 87 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(3), FARSA(5), FARSB(5), GOT1(4), GOT2(2), PAH(3), TAT(12), YARS(1), YARS2(1) 1753710 36 24 35 16 24 5 2 2 3 0 0.165 1.000 1.000 88 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(14), DAXX(5), HRAS(1), PAX3(2), PML(1), RARA(1), RB1(3), SP100(6), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TP53(26) 3773561 63 39 60 20 32 5 6 6 12 2 0.0667 1.000 1.000 89 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(3), ALPL(6), ALPP(6), ALPPL2(7), FPGS(3), GGH(2), SPR(1) 1275705 28 18 27 12 22 3 2 0 1 0 0.0830 1.000 1.000 90 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(4), GNAQ(1), HTR2C(6), PLCB1(33), TUB(5) 1434605 49 32 46 24 43 0 0 3 3 0 0.182 1.000 1.000 91 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(6), CS(1), MDH1(1), ME1(14), PC(6), PDHA1(1), SLC25A11(1) 1873371 30 20 30 14 19 4 1 4 2 0 0.242 1.000 1.000 92 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(1), CDC25A(6), CDC25B(3), CDC25C(3), MNAT1(2), SHH(2) 1755409 17 14 17 8 12 2 1 2 0 0 0.552 1.000 1.000 93 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(1), NDUFB2(1), NDUFB5(1), NDUFB6(2), NDUFS2(1), NDUFV1(1) 1408122 7 7 7 6 6 0 0 0 1 0 0.922 1.000 1.000 94 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(5), CHAT(11), CHKA(2), PCYT1A(2), PDHA1(1), PDHA2(9), PEMT(1), SLC18A3(2) 1378187 33 22 33 14 29 1 0 1 2 0 0.0834 1.000 1.000 95 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(3), POLD2(2), POLE(10), POLG(4), POLL(7), POLQ(15) 3356817 41 34 40 16 20 3 2 8 8 0 0.202 1.000 1.000 96 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(5), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(2) 1141369 11 11 11 7 7 1 1 2 0 0 0.676 1.000 1.000 97 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF2(2), CSF3(2), EPO(4), FLT3(21), IGF1(7), IL11(2), IL1A(3), IL3(2), KITLG(6), TGFB2(1), TGFB3(1) 1651719 51 32 49 21 36 3 2 5 5 0 0.0778 1.000 1.000 98 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(5), IFNG(2), IL10(2), IL12A(2), IL12B(3), IL13(2), IL15(1), IL16(10), IL18(2), IL1A(3), IL2(4), IL3(2), IL4(1), IL5(4), IL8(1), LTA(2), TNF(1) 1983790 47 27 46 21 35 3 1 1 7 0 0.0447 1.000 1.000 99 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(4), BHMT(6), CBS(5), DNMT1(13), DNMT3A(5), DNMT3B(9), MARS(5), MARS2(3), MAT1A(4), MAT2B(1), MTAP(4), MTFMT(1), MTR(5), TAT(12) 4215946 77 40 76 25 49 5 4 11 8 0 0.0123 1.000 1.000 100 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(3), APAF1(3), BCL2(2), CASP3(1), CASP9(3), CYCS(1), DAXX(5), FAS(3), FASLG(10), HSPB1(2), HSPB2(1), IL1A(3), MAPKAPK2(2), MAPKAPK3(1), TNF(1) 2288158 41 29 41 15 29 2 1 2 7 0 0.0698 1.000 1.000 101 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(5), ICAM1(2), ITGA4(26), ITGAL(17), ITGAM(19), ITGB1(4), ITGB2(10), SELE(22), SELL(6), SELP(15) 3153951 126 54 121 40 99 3 2 10 12 0 0.00132 1.000 1.000 102 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3D(5), CD3E(2), IFNG(2), IL2(4), IL2RA(4), IL4(1), TGFB2(1), TGFB3(1), TGFBR2(5), TGFBR3(5), TOB1(2), TOB2(2) 2111583 34 22 34 13 27 1 0 0 6 0 0.107 1.000 1.000 103 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(3), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(1), PSMB4(1), PSMB5(1), PSMB7(1), PSMC2(1), PSMC3(2), PSMD1(4), PSMD12(1), PSMD13(3), PSMD2(2) 3249330 28 23 27 10 17 4 2 3 2 0 0.254 1.000 1.000 104 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(6), CARS2(1), CDO1(3), GOT1(4), GOT2(2), LDHA(2), LDHAL6A(1), LDHAL6B(6), LDHC(3), MPST(2), SULT1B1(8), SULT1C2(1), SULT1C4(10), SULT4A1(7) 2524760 56 34 54 22 41 2 6 1 6 0 0.0618 1.000 1.000 105 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(1), APAF1(3), ATM(10), BAX(1), BCL2(2), CASP3(1), CASP7(4), CASP9(3), CYCS(1), EIF2S1(1), PRKCA(8), PTK2(3), PXN(3), STAT1(2), TLN1(10), TP53(26) 5478475 79 47 74 26 44 7 5 10 13 0 0.0420 1.000 1.000 106 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(6), FDPS(3), HMGCR(8), HMGCS1(1), LSS(2), MVD(1), MVK(2), NSDHL(3), PMVK(1), SC4MOL(3), SC5DL(1), SQLE(2) 2643687 34 25 33 13 18 8 0 5 3 0 0.200 1.000 1.000 107 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2) 2653090 95 56 88 32 69 7 6 8 5 0 0.00259 1.000 1.000 108 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(1), AKT2(6), AKT3(3), CDKN1A(2), ELK1(1), GRB2(2), HRAS(1), MAP2K1(7), MAP2K2(2), NGFR(6), NTRK1(10), PIK3CA(2), PIK3CD(2), SHC1(1), SOS1(6) 3185693 52 35 49 20 28 10 2 8 4 0 0.153 1.000 1.000 109 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(10), CDC25A(6), CDC25B(3), CDC25C(3), CDK4(2), CHEK1(1), MYT1(15), RB1(3), TP53(26), WEE1(2) 3535107 71 48 67 25 39 4 3 8 15 2 0.180 1.000 1.000 110 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(3), ACVR1C(7), AKT1(1), AKT2(6), AKT3(3), ARRB1(2), ARRB2(3), ATF2(5), ATF4(4), BDNF(3), BRAF(78), CACNA1A(22), CACNA1B(20), CACNA1C(30), CACNA1D(23), CACNA1E(71), CACNA1F(15), CACNA1G(23), CACNA1H(17), CACNA1I(21), CACNA1S(30), CACNA2D1(8), CACNA2D2(11), CACNA2D3(33), CACNA2D4(14), CACNB1(2), CACNB2(8), CACNB3(2), CACNB4(7), CACNG1(3), CACNG2(4), CACNG3(11), CACNG4(3), CACNG5(9), CACNG6(2), CACNG7(2), CASP3(1), CD14(4), CDC25B(3), CHP(1), CHUK(1), CRK(2), DAXX(5), DDIT3(1), DUSP10(6), DUSP14(1), DUSP16(1), DUSP2(1), DUSP4(1), DUSP5(2), DUSP6(1), DUSP7(1), DUSP8(1), DUSP9(1), ECSIT(1), EGF(14), EGFR(16), ELK1(1), ELK4(5), FAS(3), FASLG(10), FGF11(2), FGF12(10), FGF13(4), FGF14(5), FGF16(1), FGF17(1), FGF18(2), FGF19(2), FGF2(1), FGF21(2), FGF23(3), FGF3(4), FGF4(2), FGF5(3), FGF6(1), FGF7(6), FGF8(1), FGF9(2), FGFR1(7), FGFR2(21), FGFR3(7), FGFR4(8), FLNA(8), FLNB(26), FLNC(37), FOS(1), GADD45B(1), GNA12(2), GRB2(2), HRAS(1), IKBKB(2), IL1A(3), IL1B(5), IL1R1(7), IL1R2(5), JUN(1), KRAS(1), MAP2K1(7), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAP2K5(2), MAP2K6(2), MAP2K7(2), MAP3K10(5), MAP3K12(3), MAP3K13(5), MAP3K14(1), MAP3K2(4), MAP3K3(4), MAP3K4(11), MAP3K5(11), MAP3K6(6), MAP4K1(6), MAP4K2(4), MAP4K3(5), MAP4K4(6), MAPK1(3), MAPK10(6), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(4), MAPK3(1), MAPK7(2), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(6), MAPK9(1), MAPKAPK2(2), MAPKAPK3(1), MAPT(7), MEF2C(2), MKNK1(5), MKNK2(2), MOS(5), MRAS(1), MYC(2), NF1(25), NFATC2(6), NFATC4(5), NFKB1(3), NFKB2(3), NLK(4), NR4A1(2), NRAS(39), NTF3(3), NTRK1(10), NTRK2(7), PAK1(2), PAK2(2), PDGFA(1), PDGFB(2), PDGFRA(15), PDGFRB(10), PLA2G12B(3), PLA2G2A(2), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(14), PLA2G4A(8), PLA2G6(7), PPM1A(2), PPM1B(5), PPP3CA(4), PPP3CB(1), PPP3CC(1), PPP3R2(6), PPP5C(2), PRKACA(2), PRKACB(2), PRKACG(7), PRKCA(8), PRKCG(10), PRKX(1), PTPN5(9), PTPN7(1), PTPRR(19), RAC1(9), RAF1(2), RAP1A(1), RAPGEF2(6), RASA1(1), RASA2(11), RASGRF1(16), RASGRF2(11), RASGRP1(7), RASGRP2(3), RASGRP3(8), RASGRP4(9), RPS6KA1(4), RPS6KA2(4), RPS6KA4(2), RPS6KA5(4), RPS6KA6(5), RRAS(1), SOS1(6), SOS2(3), SRF(1), STK4(3), STMN1(1), TAOK1(8), TAOK2(18), TAOK3(1), TGFB2(1), TGFB3(1), TGFBR2(5), TNF(1), TNFRSF1A(2), TP53(26), TRAF2(2), TRAF6(2), ZAK(5) 56403823 1395 132 1255 750 913 116 51 192 119 4 0.0355 1.000 1.000 111 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ACTN1(2), ACTN2(14), ACTN3(5), ACTN4(3), APC(12), APC2(4), ARHGEF1(1), ARHGEF12(6), ARHGEF4(3), ARHGEF6(5), ARHGEF7(2), ARPC1B(2), ARPC2(1), ARPC3(1), BAIAP2(3), BCAR1(3), BDKRB1(5), BDKRB2(2), BRAF(78), CD14(4), CFL1(1), CHRM1(4), CHRM2(10), CHRM3(11), CHRM4(5), CHRM5(2), CRK(2), CSK(1), CYFIP1(3), CYFIP2(18), DIAPH1(6), DIAPH2(4), DIAPH3(4), DOCK1(13), EGF(14), EGFR(16), EZR(1), F2(6), F2R(4), FGD1(2), FGD3(4), FGF11(2), FGF12(10), FGF13(4), FGF14(5), FGF16(1), FGF17(1), FGF18(2), FGF19(2), FGF2(1), FGF21(2), FGF23(3), FGF3(4), FGF4(2), FGF5(3), FGF6(1), FGF7(6), FGF8(1), FGF9(2), FGFR1(7), FGFR2(21), FGFR3(7), FGFR4(8), FN1(10), GIT1(4), GNA12(2), GNA13(1), GRLF1(3), GSN(5), HRAS(1), IQGAP1(7), IQGAP2(16), IQGAP3(7), ITGA1(15), ITGA10(4), ITGA11(13), ITGA2(7), ITGA2B(7), ITGA3(4), ITGA4(26), ITGA5(13), ITGA6(6), ITGA7(15), ITGA8(26), ITGA9(9), ITGAD(17), ITGAE(8), ITGAL(17), ITGAM(19), ITGAV(5), ITGAX(14), ITGB1(4), ITGB2(10), ITGB3(9), ITGB4(12), ITGB5(1), ITGB6(8), ITGB7(4), ITGB8(10), KRAS(1), LIMK1(4), LIMK2(6), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK3(1), MOS(5), MRAS(1), MYH10(6), MYH14(14), MYH9(6), MYL2(4), MYL5(1), MYL9(1), MYLK(22), MYLK2(6), MYLPF(1), NCKAP1(2), NCKAP1L(22), NRAS(39), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PAK7(33), PDGFA(1), PDGFB(2), PDGFRA(15), PDGFRB(10), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(6), PIP5K1B(15), PIP5K1C(4), PPP1CA(1), PPP1CB(3), PPP1CC(1), PPP1R12A(3), PPP1R12B(5), PTK2(3), PXN(3), RAC1(9), RAF1(2), ROCK1(3), ROCK2(4), RRAS(1), SCIN(5), SLC9A1(1), SOS1(6), SOS2(3), SSH1(10), SSH2(6), SSH3(3), TIAM1(20), TIAM2(20), TMSL3(2), VAV1(13), VAV2(3), VAV3(6), VCL(4), WAS(5), WASF1(1), WASF2(4), WASL(3) 54964274 1181 131 1059 580 787 70 46 197 78 3 0.00163 1.000 1.000 112 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(4), ACTG1(4), ACTN1(2), ACTN2(14), ACTN3(5), ACTN4(3), AKT1(1), AKT2(6), AKT3(3), ARHGAP5(9), BCAR1(3), BCL2(2), BIRC2(4), BIRC3(6), BRAF(78), CAPN2(2), CAV1(1), CCND1(1), CCND2(4), CCND3(1), CHAD(3), COL11A1(38), COL11A2(26), COL1A1(28), COL1A2(31), COL2A1(18), COL3A1(44), COL4A1(33), COL4A2(20), COL4A4(58), COL4A6(28), COL5A1(43), COL5A2(28), COL5A3(46), COL6A1(7), COL6A2(7), COL6A3(36), COL6A6(33), COMP(5), CRK(2), CTNNB1(6), DIAPH1(6), DOCK1(13), EGF(14), EGFR(16), ELK1(1), ERBB2(3), FARP2(2), FIGF(4), FLNA(8), FLNB(26), FLNC(37), FLT1(21), FN1(10), FYN(5), GRB2(2), GRLF1(3), GSK3B(2), HGF(13), HRAS(1), IBSP(6), IGF1(7), IGF1R(6), ITGA1(15), ITGA10(4), ITGA11(13), ITGA2(7), ITGA2B(7), ITGA3(4), ITGA4(26), ITGA5(13), ITGA6(6), ITGA7(15), ITGA8(26), ITGA9(9), ITGAV(5), ITGB1(4), ITGB3(9), ITGB4(12), ITGB5(1), ITGB6(8), ITGB7(4), ITGB8(10), JUN(1), KDR(25), LAMA1(30), LAMA2(31), LAMA3(38), LAMA4(4), LAMA5(20), LAMB1(7), LAMB2(6), LAMB3(18), LAMB4(23), LAMC1(9), LAMC2(15), LAMC3(6), MAP2K1(7), MAPK1(3), MAPK10(6), MAPK3(1), MAPK9(1), MET(12), MYL2(4), MYL5(1), MYL9(1), MYLK(22), MYLK2(6), MYLPF(1), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PAK7(33), PARVA(1), PARVB(1), PARVG(3), PDGFA(1), PDGFB(2), PDGFC(14), PDGFD(5), PDGFRA(15), PDGFRB(10), PDPK1(3), PGF(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PIP5K1C(4), PPP1CA(1), PPP1CB(3), PPP1CC(1), PPP1R12A(3), PRKCA(8), PRKCG(10), PTEN(12), PTK2(3), PXN(3), RAC1(9), RAF1(2), RAP1A(1), RAPGEF1(4), RELN(46), ROCK1(3), ROCK2(4), SHC1(1), SHC2(4), SHC3(9), SHC4(1), SOS1(6), SOS2(3), SPP1(4), SRC(1), THBS1(19), THBS2(8), THBS3(7), THBS4(7), TLN1(10), TLN2(15), TNC(20), TNN(32), TNR(46), TNXB(78), VASP(1), VAV1(13), VAV2(3), VAV3(6), VCL(4), VEGFA(1), VEGFB(1), VEGFC(14), VTN(7), VWF(32), ZYX(4) 74266606 2018 128 1905 913 1480 132 54 214 136 2 0.000204 1.000 1.000 113 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(78), C7orf16(1), CACNA1A(22), CRH(2), CRHR1(2), GNA11(6), GNA12(2), GNA13(1), GNAI1(1), GNAI2(3), GNAO1(2), GNAQ(1), GNAS(12), GNAZ(4), GRIA1(33), GRIA2(22), GRIA3(19), GRID2(41), GRM1(9), GRM5(9), GUCY1A2(11), GUCY1A3(20), GUCY1B3(4), GUCY2C(20), GUCY2D(3), GUCY2F(10), HRAS(1), IGF1(7), IGF1R(6), ITPR1(19), ITPR2(10), ITPR3(4), KRAS(1), LYN(3), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK3(1), NOS1(38), NOS3(13), NPR1(13), NPR2(12), NRAS(39), PLA2G12B(3), PLA2G2A(2), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(14), PLA2G4A(8), PLA2G6(7), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(2), PPP2R2B(3), PPP2R2C(4), PRKCA(8), PRKCG(10), PRKG1(7), PRKG2(10), RAF1(2), RYR1(61) 21821592 758 128 622 385 507 37 28 139 47 0 0.00312 1.000 1.000 114 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 BRAF(78), CASP3(1), CD244(7), CD247(2), CD48(4), CHP(1), CSF2(2), FAS(3), FASLG(10), FCER1G(1), FCGR3A(5), FCGR3B(1), FYN(5), GRB2(2), GZMB(2), HLA-A(2), HLA-B(4), HLA-C(1), HLA-G(3), HRAS(1), ICAM1(2), ICAM2(4), IFNA10(2), IFNA14(6), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(3), IFNAR1(1), IFNAR2(5), IFNB1(5), IFNG(2), IFNGR1(3), IFNGR2(2), ITGAL(17), ITGB2(10), KIR2DL1(13), KIR2DL3(4), KIR2DL4(3), KIR3DL1(15), KIR3DL2(2), KLRC1(2), KLRC2(1), KLRC3(5), KLRD1(4), KLRK1(3), KRAS(1), LCK(9), LCP2(5), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK3(1), MICA(3), MICB(2), NCR1(10), NCR2(6), NCR3(2), NFAT5(3), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), NRAS(39), PAK1(2), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PLCG1(4), PLCG2(15), PPP3CA(4), PPP3CB(1), PPP3CC(1), PPP3R2(6), PRF1(6), PRKCA(8), PRKCG(10), PTK2B(7), PTPN11(5), PTPN6(1), RAC1(9), RAF1(2), SH2D1A(2), SH2D1B(3), SH3BP2(2), SHC1(1), SHC2(4), SHC3(9), SHC4(1), SOS1(6), SOS2(3), SYK(11), TNF(1), TNFRSF10A(4), TNFRSF10B(1), TNFRSF10C(4), TNFRSF10D(6), TNFSF10(5), TYROBP(2), ULBP1(2), ULBP3(5), VAV1(13), VAV2(3), VAV3(6), ZAP70(4) 22580021 616 127 504 248 387 42 27 129 31 0 0.000163 1.000 1.000 115 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(17), ADCY8(30), ATF4(4), BRAF(78), CACNA1C(30), CALM2(1), CALML3(3), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CAMK4(9), CHP(1), CREBBP(14), EP300(8), GNAQ(1), GRIA1(33), GRIA2(22), GRIN1(6), GRIN2A(57), GRIN2B(32), GRIN2C(7), GRIN2D(4), GRM1(9), GRM5(9), HRAS(1), ITPR1(19), ITPR2(10), ITPR3(4), KRAS(1), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK3(1), NRAS(39), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), PPP1CA(1), PPP1CB(3), PPP1CC(1), PPP1R12A(3), PPP1R1A(3), PPP3CA(4), PPP3CB(1), PPP3CC(1), PPP3R2(6), PRKACA(2), PRKACB(2), PRKACG(7), PRKCA(8), PRKCG(10), PRKX(1), RAF1(2), RAP1A(1), RAPGEF3(4), RPS6KA1(4), RPS6KA2(4), RPS6KA6(5) 19660533 631 126 511 320 399 40 28 129 35 0 0.0349 1.000 1.000 116 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(16), ACACB(14), AKT1(1), AKT2(6), AKT3(3), BRAF(78), CALM2(1), CALML3(3), CBL(6), CBLB(8), CBLC(12), CRK(2), ELK1(1), EXOC7(5), FASN(9), FBP1(1), FBP2(1), FLOT1(1), FOXO1(4), G6PC(4), G6PC2(2), GCK(10), GRB2(2), GSK3B(2), GYS1(2), GYS2(10), HRAS(1), IKBKB(2), INPP5D(22), INSR(13), IRS1(3), IRS2(1), IRS4(7), KRAS(1), LIPE(6), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK10(6), MAPK3(1), MAPK9(1), MKNK1(5), MKNK2(2), NRAS(39), PCK1(20), PCK2(3), PDE3A(14), PDE3B(5), PDPK1(3), PFKL(2), PHKA1(13), PHKA2(6), PHKB(5), PHKG1(1), PHKG2(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PKLR(6), PKM2(5), PPARGC1A(15), PPP1CA(1), PPP1CB(3), PPP1CC(1), PPP1R3A(45), PPP1R3B(2), PPP1R3C(2), PPP1R3D(2), PRKAA1(1), PRKAA2(18), PRKAB2(1), PRKACA(2), PRKACB(2), PRKACG(7), PRKAG1(2), PRKAG2(3), PRKAG3(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCI(5), PRKCZ(1), PRKX(1), PTPN1(2), PTPRF(19), PYGB(2), PYGL(4), PYGM(7), RAF1(2), RAPGEF1(4), RPS6(1), RPS6KB1(2), RPS6KB2(2), SH2B2(3), SHC1(1), SHC2(4), SHC3(9), SHC4(1), SLC2A4(6), SOCS2(1), SOCS3(2), SOCS4(2), SORBS1(8), SOS1(6), SOS2(3), SREBF1(3), TRIP10(2), TSC1(3), TSC2(7) 31974461 690 126 579 279 429 42 36 139 44 0 5.40e-05 1.000 1.000 117 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(3), ABL2(6), AKT1(1), AKT2(6), AKT3(3), AREG(7), BRAF(78), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CBL(6), CBLB(8), CBLC(12), CDKN1A(2), CDKN1B(1), CRK(2), EGF(14), EGFR(16), ELK1(1), ERBB2(3), ERBB3(2), ERBB4(30), GAB1(3), GRB2(2), GSK3B(2), HRAS(1), JUN(1), KRAS(1), MAP2K1(7), MAP2K2(2), MAP2K4(3), MAP2K7(2), MAPK1(3), MAPK10(6), MAPK3(1), MAPK9(1), MYC(2), NCK2(3), NRAS(39), NRG1(11), NRG2(5), NRG3(14), NRG4(1), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PAK7(33), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PLCG1(4), PLCG2(15), PRKCA(8), PRKCG(10), PTK2(3), RAF1(2), RPS6KB1(2), RPS6KB2(2), SHC1(1), SHC2(4), SHC3(9), SHC4(1), SOS1(6), SOS2(3), SRC(1), STAT5A(2), STAT5B(4), TGFA(1) 20524739 494 125 383 191 283 28 34 129 20 0 0.00490 1.000 1.000 118 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(12), ADORA1(5), ADORA2A(2), ADORA2B(1), ADORA3(10), ADRA1A(5), ADRA1B(2), ADRA2A(3), ADRA2B(5), ADRA2C(2), ADRB1(5), ADRB2(1), AGTR1(7), AGTR2(3), AVPR1A(3), AVPR1B(5), BDKRB1(5), BDKRB2(2), BRS3(2), C3AR1(3), C5AR1(6), CALCR(13), CALCRL(8), CCKAR(9), CCKBR(8), CHRM1(4), CHRM2(10), CHRM3(11), CHRM4(5), CHRM5(2), CNR1(7), CNR2(1), CRHR1(2), CRHR2(1), CTSG(4), CYSLTR1(3), CYSLTR2(2), DRD1(8), DRD2(9), DRD3(1), DRD4(1), DRD5(18), EDNRA(4), EDNRB(4), F2(6), F2R(4), F2RL1(10), F2RL2(4), FPR1(15), FSHB(2), FSHR(12), GABBR1(4), GABBR2(8), GABRA1(8), GABRA2(10), GABRA3(14), GABRA4(6), GABRA5(2), GABRA6(17), GABRB1(11), GABRB2(9), GABRB3(13), GABRD(5), GABRE(14), GABRG1(16), GABRG2(8), GABRG3(6), GABRP(9), GABRQ(4), GABRR1(6), GALR1(3), GH1(1), GH2(10), GHR(16), GHRHR(4), GHSR(6), GIPR(2), GLP1R(5), GLP2R(7), GLRA1(7), GLRA2(4), GLRA3(8), GLRB(14), GNRHR(2), GPR156(5), GPR35(2), GPR50(13), GPR63(4), GPR83(7), GRIA1(33), GRIA2(22), GRIA3(19), GRIA4(14), GRID1(17), GRID2(41), GRIK1(14), GRIK2(17), GRIK3(19), GRIK4(7), GRIK5(8), GRIN1(6), GRIN2A(57), GRIN2B(32), GRIN2C(7), GRIN2D(4), GRIN3A(29), GRIN3B(3), GRM1(9), GRM2(3), GRM3(39), GRM4(15), GRM5(9), GRM6(16), GRM7(21), GRM8(28), GRPR(3), GZMA(10), HCRTR1(1), HCRTR2(18), HRH1(11), HRH2(3), HRH3(4), HRH4(4), HTR1A(7), HTR1D(3), HTR1E(3), HTR1F(5), HTR2A(7), HTR2C(6), HTR4(5), HTR5A(11), HTR6(1), HTR7(7), LEP(1), LEPR(13), LHCGR(14), MAS1(2), MC2R(3), MC3R(6), MC4R(1), MC5R(5), MCHR1(3), MCHR2(8), MLNR(1), MTNR1A(6), MTNR1B(5), NMBR(3), NMUR1(4), NMUR2(12), NPBWR1(1), NPBWR2(6), NPFFR2(6), NPY1R(12), NPY2R(8), NPY5R(12), NR3C1(2), NTSR1(4), NTSR2(2), OPRK1(15), OPRL1(5), OPRM1(4), OXTR(3), P2RX1(2), P2RX2(1), P2RX3(5), P2RX4(2), P2RX5(6), P2RX7(3), P2RY1(2), P2RY10(6), P2RY13(3), P2RY14(5), P2RY2(5), P2RY6(1), P2RY8(4), PARD3(10), PPYR1(10), PRL(1), PRLHR(1), PRLR(22), PRSS1(11), PRSS3(2), PTAFR(1), PTGDR(7), PTGER2(5), PTGER3(2), PTGFR(13), PTGIR(3), PTH2R(9), RXFP1(10), RXFP2(12), SCTR(5), SSTR1(7), SSTR2(2), SSTR3(10), SSTR4(1), SSTR5(3), TAAR1(2), TAAR2(8), TAAR5(1), TAAR6(5), TAAR8(4), TAAR9(3), TACR1(5), TACR2(3), TACR3(17), TBXA2R(3), THRA(1), THRB(12), TRHR(13), TRPV1(2), TSHB(3), TSHR(7), UTS2R(1), VIPR1(3), VIPR2(4) 43917795 1621 125 1547 1057 1201 128 40 122 129 1 2.09e-05 1.000 1.000 119 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(4), ACTG1(4), CHAD(3), COL11A1(38), COL11A2(26), COL17A1(17), COL1A1(28), COL1A2(31), COL2A1(18), COL3A1(44), COL4A1(33), COL4A2(20), COL4A4(58), COL4A6(28), COL5A1(43), COL5A2(28), COL5A3(46), COL6A1(7), COL6A2(7), COL6A3(36), COL6A6(33), COMP(5), DES(5), DSC1(29), DSC2(29), DSC3(24), DSG1(38), DSG2(15), DSG3(40), DSG4(41), FN1(10), GJA1(6), GJA10(12), GJA3(1), GJA4(3), GJA5(5), GJA8(14), GJA9(3), GJB2(3), GJB3(2), GJB4(5), GJB5(4), GJB6(4), GJB7(1), GJC1(5), GJC3(1), GJD2(1), IBSP(6), INA(3), ITGA6(6), ITGB4(12), KRT1(12), KRT10(10), KRT12(8), KRT13(5), KRT14(1), KRT15(3), KRT16(7), KRT17(7), KRT18(2), KRT2(11), KRT20(6), KRT23(3), KRT24(4), KRT25(7), KRT27(3), KRT28(6), KRT3(7), KRT31(3), KRT32(10), KRT33A(5), KRT33B(2), KRT34(8), KRT35(6), KRT36(11), KRT37(6), KRT38(6), KRT39(9), KRT4(10), KRT40(4), KRT5(10), KRT6A(10), KRT6B(3), KRT6C(7), KRT7(3), KRT71(9), KRT72(6), KRT73(9), KRT74(7), KRT75(10), KRT76(8), KRT77(12), KRT78(15), KRT79(6), KRT8(2), KRT81(3), KRT82(5), KRT83(9), KRT84(6), KRT85(2), KRT86(6), KRT9(12), LAMA1(30), LAMA2(31), LAMA3(38), LAMA4(4), LAMA5(20), LAMB1(7), LAMB2(6), LAMB3(18), LAMB4(23), LAMC1(9), LAMC2(15), LAMC3(6), LMNA(3), LMNB1(1), LMNB2(4), NES(15), RELN(46), SPP1(4), THBS1(19), THBS2(8), THBS3(7), THBS4(7), TNC(20), TNN(32), TNR(46), TNXB(78), VIM(3), VTN(7), VWF(32) 50032725 1766 122 1720 784 1377 128 35 108 117 1 2.63e-06 1.000 1.000 120 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(8), CD36(3), CD44(5), CD47(1), CHAD(3), COL11A1(38), COL11A2(26), COL1A1(28), COL1A2(31), COL2A1(18), COL3A1(44), COL4A1(33), COL4A2(20), COL4A4(58), COL4A6(28), COL5A1(43), COL5A2(28), COL5A3(46), COL6A1(7), COL6A2(7), COL6A3(36), COL6A6(33), DAG1(3), FN1(10), FNDC1(27), FNDC3A(8), FNDC4(5), FNDC5(2), GP5(2), GP6(5), GP9(5), HMMR(4), HSPG2(19), IBSP(6), ITGA1(15), ITGA10(4), ITGA11(13), ITGA2(7), ITGA2B(7), ITGA3(4), ITGA4(26), ITGA5(13), ITGA6(6), ITGA7(15), ITGA8(26), ITGA9(9), ITGAV(5), ITGB1(4), ITGB3(9), ITGB4(12), ITGB5(1), ITGB6(8), ITGB7(4), ITGB8(10), LAMA1(30), LAMA2(31), LAMA3(38), LAMA4(4), LAMA5(20), LAMB1(7), LAMB2(6), LAMB3(18), LAMB4(23), LAMC1(9), LAMC2(15), LAMC3(6), RELN(46), SDC1(1), SDC2(1), SDC3(3), SDC4(2), SPP1(4), SV2A(15), SV2B(23), SV2C(9), THBS1(19), THBS2(8), THBS3(7), THBS4(7), TNC(20), TNN(32), TNR(46), TNXB(78), VTN(7), VWF(32) 44864342 1405 121 1376 638 1085 80 43 100 96 1 0.0480 1.000 1.000 121 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(17), ADCY2(6), ADCY3(2), ADCY4(2), ADCY7(8), ADCY8(30), ADCY9(9), ADORA2A(2), ADORA2B(1), ADRA1A(5), ADRA1B(2), ADRA1D(4), ADRB1(5), ADRB2(1), AGTR1(7), ATP2A1(6), ATP2A2(5), ATP2A3(7), ATP2B1(3), ATP2B2(15), ATP2B3(6), ATP2B4(8), AVPR1A(3), AVPR1B(5), BDKRB1(5), BDKRB2(2), CACNA1A(22), CACNA1B(20), CACNA1C(30), CACNA1D(23), CACNA1E(71), CACNA1F(15), CACNA1G(23), CACNA1H(17), CACNA1I(21), CACNA1S(30), CALM2(1), CALML3(3), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CAMK4(9), CCKAR(9), CCKBR(8), CD38(3), CHP(1), CHRM1(4), CHRM2(10), CHRM3(11), CHRM5(2), CHRNA7(2), CYSLTR1(3), CYSLTR2(2), DRD1(8), EDNRA(4), EDNRB(4), EGFR(16), ERBB2(3), ERBB3(2), ERBB4(30), F2R(4), GNA11(6), GNA14(4), GNA15(2), GNAL(2), GNAQ(1), GNAS(12), GRIN1(6), GRIN2A(57), GRIN2C(7), GRIN2D(4), GRM1(9), GRM5(9), GRPR(3), HRH1(11), HRH2(3), HTR2A(7), HTR2C(6), HTR4(5), HTR5A(11), HTR6(1), HTR7(7), ITPKB(5), ITPR1(19), ITPR2(10), ITPR3(4), LHCGR(14), MYLK(22), MYLK2(6), NOS1(38), NOS3(13), NTSR1(4), OXTR(3), P2RX1(2), P2RX2(1), P2RX3(5), P2RX4(2), P2RX5(6), P2RX7(3), PDE1A(22), PDE1B(8), PDE1C(25), PDGFRA(15), PDGFRB(10), PHKA1(13), PHKA2(6), PHKB(5), PHKG1(1), PHKG2(1), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), PLCD1(2), PLCD3(2), PLCD4(1), PLCE1(27), PLCG1(4), PLCG2(15), PLCZ1(13), PPP3CA(4), PPP3CB(1), PPP3CC(1), PPP3R2(6), PRKACA(2), PRKACB(2), PRKACG(7), PRKCA(8), PRKCG(10), PRKX(1), PTAFR(1), PTGER3(2), PTGFR(13), PTK2B(7), RYR1(61), RYR2(54), RYR3(48), SLC25A6(2), SLC8A1(14), SLC8A2(5), SLC8A3(20), SPHK1(1), SPHK2(5), TACR1(5), TACR2(3), TACR3(17), TBXA2R(3), TNNC2(2), TRHR(13), TRPC1(3), VDAC1(1), VDAC2(1), VDAC3(1) 53166145 1497 120 1442 1038 1114 101 51 108 120 3 0.253 1.000 1.000 122 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(1), ACVR1B(3), ACVR2A(3), ACVR2B(1), AMHR2(9), BMP2(4), BMP7(2), BMPR1A(1), BMPR1B(2), BMPR2(4), CCL11(1), CCL14(2), CCL15(2), CCL16(1), CCL18(1), CCL2(1), CCL21(2), CCL24(1), CCL25(1), CCL28(1), CCL7(4), CCL8(3), CCR1(5), CCR2(8), CCR3(8), CCR4(5), CCR5(5), CCR6(1), CCR7(3), CCR8(2), CCR9(3), CD27(2), CD40(1), CD40LG(2), CLCF1(1), CNTFR(3), CSF1(8), CSF1R(9), CSF2(2), CSF2RA(11), CSF2RB(14), CSF3(2), CSF3R(6), CX3CL1(2), CX3CR1(10), CXCL10(2), CXCL11(1), CXCL12(1), CXCL14(1), CXCL3(1), CXCL5(2), CXCL9(2), CXCR3(2), CXCR4(1), CXCR6(4), EDA(1), EDA2R(3), EDAR(4), EGF(14), EGFR(16), EPO(4), EPOR(1), FAS(3), FASLG(10), FLT1(21), FLT3(21), FLT3LG(1), FLT4(19), GDF5(9), GH1(1), GH2(10), GHR(16), HGF(13), IFNA10(2), IFNA14(6), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(3), IFNAR1(1), IFNAR2(5), IFNB1(5), IFNG(2), IFNGR1(3), IFNGR2(2), IFNK(1), IFNW1(4), IL10(2), IL10RA(5), IL10RB(4), IL11(2), IL11RA(1), IL12A(2), IL12B(3), IL12RB1(9), IL12RB2(3), IL13(2), IL13RA1(3), IL15(1), IL15RA(4), IL17A(7), IL17RA(4), IL17RB(1), IL18(2), IL18R1(14), IL18RAP(13), IL19(2), IL1A(3), IL1B(5), IL1R1(7), IL1R2(5), IL1RAP(3), IL2(4), IL20(3), IL20RA(8), IL21(2), IL21R(11), IL22(1), IL22RA1(6), IL22RA2(1), IL23A(1), IL23R(2), IL25(1), IL26(2), IL28A(1), IL28B(2), IL28RA(4), IL29(1), IL2RA(4), IL2RB(7), IL2RG(2), IL3(2), IL3RA(4), IL4(1), IL4R(7), IL5(4), IL5RA(7), IL6R(2), IL6ST(6), IL7(3), IL7R(15), IL8(1), IL9R(4), INHBA(12), INHBB(4), INHBC(6), INHBE(2), KDR(25), KIT(7), KITLG(6), LEP(1), LEPR(13), LIF(1), LIFR(14), LTA(2), LTB(1), MET(12), MPL(2), NGFR(6), OSM(2), OSMR(28), PDGFB(2), PDGFC(14), PDGFRA(15), PDGFRB(10), PLEKHO2(5), PPBP(3), PRL(1), PRLR(22), RELT(1), TGFB2(1), TGFB3(1), TGFBR2(5), TNF(1), TNFRSF10A(4), TNFRSF10B(1), TNFRSF10C(4), TNFRSF10D(6), TNFRSF11A(5), TNFRSF11B(9), TNFRSF13B(7), TNFRSF14(2), TNFRSF17(4), TNFRSF18(3), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(7), TNFRSF25(4), TNFRSF4(4), TNFRSF6B(2), TNFRSF8(11), TNFRSF9(3), TNFSF10(5), TNFSF11(4), TNFSF12(1), TNFSF14(6), TNFSF15(7), TNFSF18(5), TNFSF4(3), TNFSF8(2), TNFSF9(1), TPO(30), TSLP(1), VEGFA(1), VEGFB(1), VEGFC(14), XCL1(1), XCL2(2), XCR1(3) 35363323 1018 120 987 582 766 71 19 65 97 0 0.106 1.000 1.000 123 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(78), CPEB1(5), EGFR(16), ERBB2(3), ERBB4(30), ETS1(3), ETS2(8), ETV6(8), ETV7(2), FMN2(50), GRB2(2), KRAS(1), MAP2K1(7), MAPK1(3), MAPK3(1), NOTCH1(4), NOTCH2(25), NOTCH3(16), NOTCH4(38), PIWIL1(17), PIWIL2(8), PIWIL3(11), PIWIL4(3), RAF1(2), SOS1(6), SOS2(3), SPIRE2(3) 10513489 353 119 282 125 208 20 7 103 15 0 0.0134 1.000 1.000 124 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(3), ACTN1(2), ACTR2(2), AKT1(1), AKT2(6), AKT3(3), ANGPTL2(2), ARHGEF6(5), ARHGEF7(2), BCAR1(3), BRAF(78), CAV1(1), CDKN2A(23), CRK(2), CSE1L(4), DOCK1(13), EPHB2(17), FYN(5), GRB2(2), GRB7(5), GRLF1(3), ITGA1(15), ITGA10(4), ITGA11(13), ITGA2(7), ITGA3(4), ITGA4(26), ITGA5(13), ITGA6(6), ITGA7(15), ITGA8(26), ITGA9(9), MAP2K4(3), MAP2K7(2), MAP3K11(4), MAPK1(3), MAPK10(6), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(6), MAPK9(1), MRAS(1), MYLK(22), MYLK2(6), P4HB(2), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PAK7(33), PIK3CA(2), PIK3CB(10), PKLR(6), PLCG1(4), PLCG2(15), PTEN(12), PTK2(3), RAF1(2), RHO(2), ROCK1(3), ROCK2(4), SHC1(1), SOS1(6), SOS2(3), SRC(1), TLN1(10), TLN2(15), VASP(1), WAS(5), ZYX(4) 24337206 540 117 458 231 322 30 19 114 55 0 0.00644 1.000 1.000 125 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(3), ABLIM1(9), ABLIM2(2), ABLIM3(4), ARHGEF12(6), CDK5(3), CFL1(1), CHP(1), CXCL12(1), CXCR4(1), DCC(54), DPYSL2(4), DPYSL5(9), EFNA4(1), EFNA5(2), EFNB1(1), EFNB3(1), EPHA1(7), EPHA2(8), EPHA3(16), EPHA4(11), EPHA5(6), EPHA6(40), EPHA7(29), EPHA8(11), EPHB1(17), EPHB2(17), EPHB3(11), EPHB4(3), EPHB6(14), FES(4), FYN(5), GNAI1(1), GNAI2(3), GSK3B(2), HRAS(1), ITGB1(4), KRAS(1), L1CAM(5), LIMK1(4), LIMK2(6), LRRC4C(23), MAPK1(3), MAPK3(1), MET(12), NCK2(3), NFAT5(3), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), NGEF(8), NRAS(39), NRP1(14), NTN4(13), NTNG1(7), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PAK7(33), PLXNA1(7), PLXNA2(7), PLXNA3(5), PLXNB1(16), PLXNB2(8), PLXNB3(3), PLXNC1(12), PPP3CA(4), PPP3CB(1), PPP3CC(1), PPP3R2(6), PTK2(3), RAC1(9), RASA1(1), RGS3(8), RHOD(1), RND1(4), ROBO1(14), ROBO2(24), ROBO3(10), ROCK1(3), ROCK2(4), SEMA3A(10), SEMA3B(2), SEMA3C(2), SEMA3D(9), SEMA3E(14), SEMA3F(6), SEMA3G(8), SEMA4A(5), SEMA4B(4), SEMA4C(4), SEMA4D(6), SEMA4F(5), SEMA4G(5), SEMA5A(10), SEMA5B(10), SEMA6A(5), SEMA6B(5), SEMA6C(6), SEMA6D(3), SEMA7A(3), SLIT1(11), SLIT2(39), SLIT3(34), SRGAP2(2), SRGAP3(22), UNC5A(7), UNC5B(8), UNC5C(11), UNC5D(15) 38938465 955 115 887 495 683 66 32 101 71 2 0.0128 1.000 1.000 126 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(3), ACTA2(3), ACTN2(14), ACTN3(5), ACTN4(3), DES(5), DMD(18), MYBPC1(12), MYBPC2(10), MYBPC3(7), MYH3(15), MYH6(19), MYH7(29), MYH8(35), MYL1(9), MYL2(4), MYL3(2), MYL4(5), MYL9(1), MYOM1(14), NEB(81), TCAP(1), TNNC2(2), TNNI1(1), TNNI2(1), TNNI3(1), TNNT1(3), TNNT2(2), TNNT3(3), TPM2(2), TPM3(2), TPM4(1), TTN(717), VIM(3) 26445892 1033 115 977 440 789 70 35 79 51 9 4.36e-06 1.000 1.000 127 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(17), ADCY2(6), ADCY3(2), ADCY4(2), ADCY5(9), ADCY6(6), ADCY7(8), ADCY8(30), ADCY9(9), ADRA1A(5), ADRA1B(2), ADRA1D(4), ADRB1(5), ADRB2(1), ANXA6(3), ARRB1(2), ARRB2(3), ATP1A4(9), ATP1B1(1), ATP2A2(5), ATP2A3(7), ATP2B1(3), ATP2B2(15), ATP2B3(6), CACNA1A(22), CACNA1B(20), CACNA1C(30), CACNA1D(23), CACNA1E(71), CACNA1S(30), CACNB1(2), CACNB3(2), CALM2(1), CAMK1(4), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CAMK4(9), CASQ1(6), CASQ2(3), CHRM1(4), CHRM2(10), CHRM3(11), CHRM4(5), CHRM5(2), GJA1(6), GJA4(3), GJA5(5), GJB2(3), GJB3(2), GJB4(5), GJB5(4), GJB6(4), GNA11(6), GNAI2(3), GNAO1(2), GNAQ(1), GNAZ(4), GNB3(5), GNB4(1), GNB5(2), GNG2(3), GNG4(2), GNG7(2), GRK4(6), GRK5(3), GRK6(1), ITPR1(19), ITPR2(10), ITPR3(4), KCNB1(18), KCNJ3(14), KCNJ5(6), MIB1(4), NME7(4), PKIA(1), PKIB(1), PKIG(1), PLCB3(2), PRKACA(2), PRKACB(2), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(8), PRKCD(2), PRKCE(4), PRKCG(10), PRKCH(5), PRKCQ(12), PRKCZ(1), PRKD1(2), RGS1(3), RGS11(2), RGS14(3), RGS16(1), RGS18(7), RGS20(1), RGS3(8), RGS4(2), RGS5(2), RGS6(10), RGS7(26), RGS9(9), RYR1(61), RYR2(54), RYR3(48), SFN(1), SLC8A1(14), SLC8A3(20), USP5(3), YWHAQ(2) 37175699 917 114 879 647 666 81 30 64 73 3 0.507 1.000 1.000 128 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(1), AKT2(6), AKT3(3), CBL(6), CBLB(8), CBLC(12), CCND1(1), CCND2(4), CCND3(1), CISH(2), CLCF1(1), CNTFR(3), CREBBP(14), CSF2(2), CSF2RA(11), CSF2RB(14), CSF3(2), CSF3R(6), EP300(8), EPO(4), EPOR(1), GH1(1), GH2(10), GHR(16), GRB2(2), IFNA10(2), IFNA14(6), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(3), IFNAR1(1), IFNAR2(5), IFNB1(5), IFNG(2), IFNGR1(3), IFNGR2(2), IFNK(1), IFNW1(4), IL10(2), IL10RA(5), IL10RB(4), IL11(2), IL11RA(1), IL12A(2), IL12B(3), IL12RB1(9), IL12RB2(3), IL13(2), IL13RA1(3), IL13RA2(2), IL15(1), IL15RA(4), IL19(2), IL2(4), IL20(3), IL20RA(8), IL21(2), IL21R(11), IL22(1), IL22RA1(6), IL22RA2(1), IL23A(1), IL23R(2), IL26(2), IL28A(1), IL28B(2), IL28RA(4), IL29(1), IL2RA(4), IL2RB(7), IL2RG(2), IL3(2), IL3RA(4), IL4(1), IL4R(7), IL5(4), IL5RA(7), IL6R(2), IL6ST(6), IL7(3), IL7R(15), IL9R(4), IRF9(1), JAK1(4), JAK2(6), JAK3(5), LEP(1), LEPR(13), LIF(1), LIFR(14), MPL(2), MYC(2), OSM(2), OSMR(28), PIAS1(2), PIAS2(4), PIAS3(3), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PIM1(1), PRL(1), PRLR(22), PTPN11(5), PTPN6(1), SOCS2(1), SOCS3(2), SOCS4(2), SOCS5(4), SOCS7(3), SOS1(6), SOS2(3), SPRED1(3), SPRED2(1), SPRY1(6), SPRY2(3), SPRY3(7), SPRY4(1), STAM(2), STAT1(2), STAT2(6), STAT3(6), STAT4(13), STAT5A(2), STAT5B(4), STAT6(5), TPO(30), TSLP(1), TYK2(4) 29135844 635 114 621 332 456 49 21 53 56 0 0.270 1.000 1.000 129 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(12), APC2(4), AXIN1(6), AXIN2(2), BTRC(4), CACYBP(1), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CCND1(1), CCND2(4), CCND3(1), CER1(7), CHD8(14), CHP(1), CREBBP(14), CSNK1A1(2), CSNK1A1L(3), CSNK1E(3), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), CTBP2(1), CTNNB1(6), CTNNBIP1(1), CUL1(4), DAAM1(3), DAAM2(2), DKK1(1), DKK2(9), DKK4(1), DVL2(3), DVL3(5), EP300(8), FBXW11(4), FZD1(1), FZD10(1), FZD2(4), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(3), GSK3B(2), JUN(1), LEF1(1), LRP5(13), LRP6(13), MAPK10(6), MAPK9(1), MMP7(3), MYC(2), NFAT5(3), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), NKD1(5), NKD2(4), NLK(4), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), PORCN(3), PPARD(2), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(2), PPP2R2B(3), PPP2R2C(4), PPP3CA(4), PPP3CB(1), PPP3CC(1), PPP3R2(6), PRICKLE1(5), PRICKLE2(3), PRKACA(2), PRKACB(2), PRKACG(7), PRKCA(8), PRKCG(10), PRKX(1), PSEN1(1), RAC1(9), ROCK1(3), ROCK2(4), SENP2(9), SFRP2(8), SFRP4(4), SMAD2(1), SOX17(3), TBL1X(1), TBL1XR1(1), TBL1Y(4), TCF7(1), TCF7L1(1), TCF7L2(4), TP53(26), VANGL1(1), VANGL2(6), WIF1(5), WNT1(1), WNT10A(4), WNT10B(4), WNT11(2), WNT16(1), WNT2(6), WNT2B(2), WNT3(4), WNT3A(5), WNT4(2), WNT5A(5), WNT5B(2), WNT6(2), WNT7A(10), WNT7B(2), WNT8A(4), WNT8B(5), WNT9A(1), WNT9B(3) 32114105 557 113 534 264 374 41 23 66 53 0 0.0401 1.000 1.000 130 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(3), ACTA2(3), ADCY1(17), ADCY2(6), ADCY3(2), ADCY4(2), ADCY5(9), ADCY6(6), ADCY7(8), ADCY8(30), ADCY9(9), ARRB1(2), ARRB2(3), ATF1(3), ATF2(5), ATF4(4), ATF5(3), ATP2A2(5), ATP2A3(7), CACNB3(2), CALM2(1), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CNN1(2), CNN2(2), CORIN(19), CRH(2), CRHR1(2), DGKZ(6), ETS2(8), FOS(1), GABPB2(5), GBA2(2), GJA1(6), GNAQ(1), GNB3(5), GNB4(1), GNB5(2), GNG2(3), GNG4(2), GNG7(2), GRK4(6), GRK5(3), GRK6(1), GSTO1(2), GUCY1A3(20), IGFBP1(2), IGFBP2(2), IGFBP3(1), IGFBP6(2), IL1B(5), ITPR1(19), ITPR2(10), ITPR3(4), JUN(1), MIB1(4), MYL2(4), MYL4(5), MYLK2(6), NFKB1(3), NOS1(38), NOS3(13), OXTR(3), PDE4B(6), PDE4D(5), PKIA(1), PKIB(1), PKIG(1), PLCB3(2), PLCD1(2), PLCG1(4), PLCG2(15), PRKACA(2), PRKACB(2), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(8), PRKCD(2), PRKCE(4), PRKCH(5), PRKCQ(12), PRKCZ(1), PRKD1(2), RAMP1(1), RAMP3(1), RGS1(3), RGS11(2), RGS14(3), RGS16(1), RGS18(7), RGS20(1), RGS3(8), RGS4(2), RGS5(2), RGS6(10), RGS7(26), RGS9(9), RLN1(3), RYR1(61), RYR2(54), RYR3(48), SFN(1), SLC8A1(14), SP1(4), TNXB(78), USP5(3), YWHAQ(2) 34765708 794 113 766 487 592 62 22 57 58 3 0.0934 1.000 1.000 131 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(5), ADORA2A(2), ADORA2B(1), ADORA3(10), ADRA1A(5), ADRA1B(2), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(1), AGTR1(7), AGTR2(3), AVPR1A(3), AVPR1B(5), BDKRB1(5), BDKRB2(2), BRS3(2), C3AR1(3), CCBP2(6), CCKAR(9), CCKBR(8), CCR1(5), CCR10(2), CCR2(8), CCR3(8), CCR4(5), CCR5(5), CCR6(1), CCR7(3), CCR8(2), CCR9(3), CCRL2(2), CHML(2), CHRM1(4), CHRM2(10), CHRM3(11), CHRM4(5), CHRM5(2), CMKLR1(10), CNR1(7), CNR2(1), CX3CR1(10), CXCR3(2), CXCR4(1), DRD1(8), DRD2(9), DRD3(1), DRD4(1), DRD5(18), EDNRA(4), EDNRB(4), F2R(4), F2RL1(10), F2RL2(4), FPR1(15), FSHR(12), GALR1(3), GALT(2), GHSR(6), GNB2L1(2), GPR17(1), GPR173(1), GPR174(8), GPR27(2), GPR3(2), GPR35(2), GPR37(4), GPR37L1(4), GPR4(3), GPR50(13), GPR6(5), GPR63(4), GPR77(3), GPR83(7), GPR85(4), GPR87(3), GRPR(3), HCRTR1(1), HCRTR2(18), HRH1(11), HRH2(3), HRH3(4), HTR1A(7), HTR1D(3), HTR1E(3), HTR1F(5), HTR2A(7), HTR2C(6), HTR4(5), HTR5A(11), HTR6(1), HTR7(7), LHCGR(14), MAS1(2), MC3R(6), MC4R(1), MC5R(5), MLNR(1), MTNR1A(6), MTNR1B(5), NMBR(3), NMUR1(4), NMUR2(12), NPY1R(12), NPY2R(8), NPY5R(12), NTSR1(4), NTSR2(2), OPN1SW(2), OPN3(2), OPRK1(15), OPRL1(5), OPRM1(4), OR10A5(4), OR11A1(2), OR12D3(5), OR1C1(7), OR1F1(3), OR1Q1(4), OR2H1(4), OR5V1(7), OR7A5(1), OR7C1(1), OR8B8(7), OXTR(3), P2RY1(2), P2RY10(6), P2RY12(2), P2RY13(3), P2RY14(5), P2RY2(5), P2RY6(1), PPYR1(10), PTAFR(1), PTGDR(7), PTGER2(5), PTGFR(13), PTGIR(3), RGR(3), RHO(2), SSTR1(7), SSTR2(2), SSTR3(10), SSTR4(1), SUCNR1(7), TBXA2R(3), TRHR(13) 24216560 750 111 724 606 526 78 23 70 53 0 0.0703 1.000 1.000 132 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(4), ACTG1(4), ACTN1(2), ACTN2(14), ACTN3(5), ACTN4(3), AKT1(1), AKT2(6), AKT3(3), AMOTL1(2), ASH1L(21), CASK(2), CDK4(2), CGN(6), CLDN1(5), CLDN10(3), CLDN11(3), CLDN14(5), CLDN16(4), CLDN17(3), CLDN18(6), CLDN19(2), CLDN2(4), CLDN20(1), CLDN22(1), CLDN4(7), CLDN6(6), CLDN7(1), CLDN8(2), CLDN9(1), CSDA(2), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(17), CTNNA3(19), CTNNB1(6), CTTN(1), EPB41(5), EPB41L1(7), EPB41L2(10), EPB41L3(6), EXOC3(2), EXOC4(5), F11R(4), GNAI1(1), GNAI2(3), HCLS1(7), HRAS(1), IGSF5(6), INADL(31), JAM2(9), JAM3(1), KRAS(1), LLGL1(2), LLGL2(10), MAGI1(19), MAGI2(16), MAGI3(9), MLLT4(9), MPDZ(8), MRAS(1), MYH1(54), MYH10(6), MYH11(23), MYH13(22), MYH14(14), MYH15(34), MYH2(53), MYH3(15), MYH4(46), MYH6(19), MYH7(29), MYH7B(22), MYH8(35), MYH9(6), MYL2(4), MYL5(1), MYL9(1), MYLPF(1), NRAS(39), OCLN(2), PARD3(10), PARD6B(1), PARD6G(2), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(2), PPP2R2B(3), PPP2R2C(4), PPP2R3A(2), PPP2R3B(3), PPP2R4(1), PRKCA(8), PRKCD(2), PRKCE(4), PRKCG(10), PRKCH(5), PRKCI(5), PRKCQ(12), PRKCZ(1), PTEN(12), RRAS(1), SPTAN1(4), SRC(1), SYMPK(2), TJAP1(2), TJP1(9), TJP2(5), TJP3(13), YES1(3), ZAK(5) 38662530 917 111 853 601 626 76 41 91 80 3 0.842 1.000 1.000 133 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(5), BRAF(78), CHUK(1), DAXX(5), ELK1(1), FOS(1), GRB2(2), HRAS(1), IKBKB(2), JUN(1), MAP2K1(7), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAP2K5(2), MAP2K6(2), MAP2K7(2), MAP3K10(5), MAP3K11(4), MAP3K12(3), MAP3K13(5), MAP3K14(1), MAP3K2(4), MAP3K3(4), MAP3K4(11), MAP3K5(11), MAP3K6(6), MAP3K9(17), MAP4K1(6), MAP4K2(4), MAP4K3(5), MAP4K4(6), MAP4K5(3), MAPK1(3), MAPK10(6), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(4), MAPK3(1), MAPK4(10), MAPK6(3), MAPK7(2), MAPK9(1), MAPKAPK2(2), MAPKAPK3(1), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), MKNK1(5), MKNK2(2), MYC(2), NFKB1(3), NFKBIA(2), PAK1(2), PAK2(2), RAC1(9), RAF1(2), RELA(2), RIPK1(1), RPS6KA1(4), RPS6KA2(4), RPS6KA4(2), RPS6KA5(4), RPS6KB1(2), RPS6KB2(2), SHC1(1), SP1(4), STAT1(2), TGFB2(1), TGFB3(1), TRAF2(2) 18888553 322 111 253 131 174 31 13 87 17 0 0.0765 1.000 1.000 134 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(1), AKT2(6), AKT3(3), BRAF(78), DAG1(3), DRD2(9), EGFR(16), EPHB2(17), GRB2(2), ITPKB(5), ITPR1(19), ITPR2(10), ITPR3(4), KCNJ3(14), KCNJ5(6), KCNJ9(4), MAPK1(3), PI3(6), PIK3CB(10), PITX2(1), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), RAF1(2), RGS20(1), SHC1(1), SOS1(6), SOS2(3), SRC(1), STAT3(6) 11715797 321 111 248 152 184 24 12 83 18 0 0.118 1.000 1.000 135 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(17), ADCY2(6), ADCY3(2), ADCY4(2), ADCY5(9), ADCY6(6), ADCY7(8), ADCY8(30), ADCY9(9), ADRB1(5), CSNK1D(1), DRD1(8), DRD2(9), EGF(14), EGFR(16), GJA1(6), GJD2(1), GNA11(6), GNAI1(1), GNAI2(3), GNAQ(1), GNAS(12), GRB2(2), GRM1(9), GRM5(9), GUCY1A2(11), GUCY1A3(20), GUCY1B3(4), GUCY2C(20), GUCY2D(3), GUCY2F(10), HRAS(1), HTR2A(7), HTR2C(6), ITPR1(19), ITPR2(10), ITPR3(4), KRAS(1), MAP2K1(7), MAP2K2(2), MAP2K5(2), MAP3K2(4), MAPK1(3), MAPK3(1), MAPK7(2), NPR1(13), NPR2(12), NRAS(39), PDGFA(1), PDGFB(2), PDGFC(14), PDGFD(5), PDGFRA(15), PDGFRB(10), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), PRKACA(2), PRKACB(2), PRKACG(7), PRKCA(8), PRKCG(10), PRKG1(7), PRKG2(10), PRKX(1), RAF1(2), SOS1(6), SOS2(3), SRC(1), TJP1(9), TUBA1A(1), TUBA1B(3), TUBA1C(2), TUBA3C(12), TUBA3D(9), TUBA3E(1), TUBA4A(4), TUBA8(1), TUBAL3(8), TUBB1(2), TUBB2A(2), TUBB3(3), TUBB4(1), TUBB4Q(5), TUBB6(6), TUBB8(7) 26285927 659 110 593 390 461 41 31 78 48 0 0.161 1.000 1.000 136 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(17), ADCY2(6), ADCY3(2), ADCY4(2), ADCY5(9), ADCY6(6), ADCY7(8), ADCY8(30), ADCY9(9), CALM2(1), CALML3(3), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CREB3L1(3), CREB3L2(5), CREB3L3(6), CREB3L4(2), CREBBP(14), CTNNB1(6), DCT(2), DVL2(3), DVL3(5), EDN1(7), EDNRB(4), EP300(8), FZD1(1), FZD10(1), FZD2(4), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(3), GNAI1(1), GNAI2(3), GNAO1(2), GNAQ(1), GNAS(12), GSK3B(2), HRAS(1), KIT(7), KITLG(6), KRAS(1), LEF1(1), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK3(1), MITF(2), NRAS(39), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), POMC(3), PRKACA(2), PRKACB(2), PRKACG(7), PRKCA(8), PRKCG(10), PRKX(1), RAF1(2), TCF7(1), TCF7L1(1), TCF7L2(4), TYR(5), TYRP1(5), WNT1(1), WNT10A(4), WNT10B(4), WNT11(2), WNT16(1), WNT2(6), WNT2B(2), WNT3(4), WNT3A(5), WNT4(2), WNT5A(5), WNT5B(2), WNT6(2), WNT7A(10), WNT7B(2), WNT8A(4), WNT8B(5), WNT9A(1), WNT9B(3) 21575449 476 110 422 263 316 32 24 65 39 0 0.117 1.000 1.000 137 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(17), ADCY2(6), ADCY3(2), ADCY4(2), ADCY5(9), ADCY6(6), ADCY7(8), ADCY8(30), ADCY9(9), ATF4(4), CACNA1C(30), CACNA1D(23), CACNA1F(15), CACNA1S(30), CALM2(1), CALML3(3), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), EGFR(16), ELK1(1), FSHB(2), GNA11(6), GNAQ(1), GNAS(12), GNRH2(2), GNRHR(2), GRB2(2), HRAS(1), ITPR1(19), ITPR2(10), ITPR3(4), JUN(1), KRAS(1), MAP2K1(7), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP2K7(2), MAP3K2(4), MAP3K3(4), MAP3K4(11), MAPK1(3), MAPK10(6), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(4), MAPK3(1), MAPK7(2), MAPK9(1), MMP2(3), NRAS(39), PLA2G12B(3), PLA2G2A(2), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(14), PLA2G4A(8), PLA2G6(7), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), PLD1(7), PLD2(3), PRKACA(2), PRKACB(2), PRKACG(7), PRKCA(8), PRKCD(2), PRKX(1), PTK2B(7), RAF1(2), SOS1(6), SOS2(3), SRC(1) 25178670 569 109 512 354 386 45 30 66 42 0 0.430 1.000 1.000 138 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(17), ADCY2(6), ADCY3(2), ADCY4(2), ADCY5(9), ADCY6(6), ADCY7(8), ADCY8(30), ADCY9(9), AKAP1(7), AKAP10(1), AKAP11(8), AKAP12(1), AKAP3(10), AKAP4(7), AKAP6(18), AKAP7(3), AKAP8(6), AKAP9(20), ARHGEF1(1), CALM2(1), CHMP1B(1), GNA11(6), GNA12(2), GNA13(1), GNA14(4), GNA15(2), GNAI2(3), GNAL(2), GNAO1(2), GNAQ(1), GNAZ(4), GNB3(5), GNB5(2), GNG4(2), GNG7(2), GNGT2(3), HRAS(1), ITPR1(19), KCNJ3(14), KRAS(1), NRAS(39), PDE1A(22), PDE1B(8), PDE1C(25), PDE4A(3), PDE4B(6), PDE4C(11), PDE4D(5), PDE7B(12), PDE8A(2), PDE8B(12), PLCB3(2), PPP3CA(4), PPP3CC(1), PRKACA(2), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(8), PRKCD(2), PRKCE(4), PRKCG(10), PRKCH(5), PRKCI(5), PRKCQ(12), PRKCZ(1), PRKD1(2), PRKD3(3), RRAS(1), SLC9A1(1), USP5(3) 23372243 477 107 432 265 319 34 24 65 35 0 0.242 1.000 1.000 139 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(14), AMY2A(4), AMY2B(7), ASCC3(5), ATP13A2(7), DDX18(4), DDX19A(1), DDX23(5), DDX4(8), DDX41(4), DDX47(1), DDX50(2), DDX51(3), DDX52(3), DDX54(2), DDX55(2), DDX56(2), DHX58(4), ENPP1(9), ENPP3(10), ENTPD7(1), EP400(16), ERCC2(1), ERCC3(3), G6PC(4), G6PC2(2), GAA(5), GANC(2), GBA(2), GBA3(6), GBE1(7), GCK(10), GPI(2), GUSB(3), GYS1(2), GYS2(10), HK1(1), HK2(5), HK3(10), IFIH1(8), MGAM(89), MOV10L1(17), NUDT5(1), NUDT8(1), PGM1(2), PGM3(1), PYGB(2), PYGL(4), PYGM(7), RAD54B(5), RUVBL2(2), SETX(13), SI(44), SKIV2L2(3), SMARCA2(9), SMARCA5(3), TREH(3), UGP2(1), UGT1A1(1), UGT1A10(13), UGT1A3(7), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(9), UGT1A8(3), UGT1A9(6), UGT2A1(12), UGT2A3(17), UGT2B10(20), UGT2B11(11), UGT2B15(18), UGT2B28(15), UGT2B4(23), UGT2B7(13), UXS1(1) 24548396 584 107 560 253 410 45 19 52 58 0 0.00111 1.000 1.000 140 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(17), BDKRB1(5), BDKRB2(2), C1QA(3), C1QB(2), C1QC(6), C1R(9), C1S(15), C2(9), C3(29), C3AR1(3), C4BPA(11), C4BPB(3), C5(9), C5AR1(6), C6(39), C7(25), C8A(27), C8B(30), C9(14), CD55(2), CD59(1), CFB(23), CFH(31), CFI(9), CR1(35), CR2(20), F10(4), F11(9), F12(1), F13A1(20), F13B(16), F2(6), F2R(4), F5(20), F7(2), F8(29), F9(6), FGA(20), FGB(7), FGG(4), KLKB1(16), KNG1(4), MASP1(6), MASP2(7), MBL2(8), PLAT(2), PLAU(2), PLAUR(1), PLG(20), PROC(7), PROS1(9), SERPINA1(7), SERPINA5(8), SERPINC1(5), SERPIND1(2), SERPINE1(2), SERPINF2(3), SERPING1(8), TFPI(5), THBD(2), VWF(32) 18052490 689 107 657 303 511 49 26 55 46 2 0.00284 1.000 1.000 141 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(2), ADCY1(17), ADCY2(6), ADCY3(2), ADCY4(2), ADCY5(9), ADCY6(6), ADCY7(8), ADCY8(30), ADCY9(9), ADK(3), ADSL(6), ADSS(1), ADSSL1(4), AK1(1), AK2(1), AK5(6), AK7(17), ALLC(5), AMPD1(22), AMPD2(4), AMPD3(16), APRT(1), ATIC(2), CANT1(8), DGUOK(4), ENPP1(9), ENPP3(10), ENTPD1(5), ENTPD2(4), ENTPD3(3), ENTPD4(3), ENTPD5(1), ENTPD6(3), ENTPD8(1), FHIT(2), GART(7), GDA(6), GMPR2(1), GMPS(3), GUCY1A2(11), GUCY1A3(20), GUCY1B3(4), GUCY2C(20), GUCY2D(3), GUCY2F(10), GUK1(1), IMPDH2(1), NME6(1), NME7(4), NPR1(13), NPR2(12), NT5C1A(1), NT5C1B(16), NT5C2(1), NT5C3(2), NT5E(4), NT5M(1), NUDT5(1), NUDT9(2), PAPSS1(2), PAPSS2(4), PDE10A(6), PDE11A(15), PDE1A(22), PDE1C(25), PDE2A(11), PDE3B(5), PDE4A(3), PDE4B(6), PDE4C(11), PDE4D(5), PDE5A(5), PDE6D(2), PDE6G(2), PDE7B(12), PDE8A(2), PDE8B(12), PDE9A(6), PFAS(5), PKLR(6), PKM2(5), PNPT1(1), POLA1(1), POLA2(6), POLD1(3), POLD2(2), POLD3(3), POLE(10), POLE2(1), POLR1A(7), POLR1B(5), POLR1C(1), POLR2A(10), POLR2B(11), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(2), POLR3B(12), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(8), PRPS1(1), PRPS1L1(8), PRPS2(1), PRUNE(1), RRM1(3), RRM2B(1), XDH(38) 32709594 696 106 678 349 486 52 30 69 59 0 0.00503 1.000 1.000 142 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM2(1), CALML3(3), CDS1(6), CDS2(4), DGKA(1), DGKB(16), DGKD(5), DGKE(5), DGKG(10), DGKH(6), DGKI(14), DGKQ(3), DGKZ(6), IMPA1(1), IMPA2(2), INPP1(2), INPP4A(4), INPP5A(3), INPP5B(4), INPP5D(22), INPPL1(11), ITPK1(5), ITPKB(5), ITPR1(19), ITPR2(10), ITPR3(4), OCRL(3), PI4KA(9), PI4KB(3), PIK3C2A(4), PIK3C2B(9), PIK3C2G(32), PIK3C3(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(6), PIP5K1B(15), PIP5K1C(4), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), PLCD1(2), PLCD3(2), PLCD4(1), PLCE1(27), PLCG1(4), PLCG2(15), PLCZ1(13), PRKCA(8), PRKCG(10), PTEN(12), SYNJ1(11), SYNJ2(11) 24752827 510 106 490 245 373 30 20 38 49 0 0.00344 1.000 1.000 143 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 110 ABL1(3), ANAPC1(8), ANAPC10(1), ANAPC2(3), ANAPC4(1), ANAPC5(4), ANAPC7(4), ATM(10), ATR(13), BUB1(1), BUB1B(7), CCNA1(12), CCNB2(1), CCNB3(17), CCND1(1), CCND2(4), CCND3(1), CCNE1(3), CCNE2(10), CCNH(1), CDC14A(2), CDC14B(1), CDC16(1), CDC25A(6), CDC25B(3), CDC25C(3), CDC27(6), CDC6(1), CDC7(2), CDK4(2), CDK6(1), CDKN1A(2), CDKN1B(1), CDKN2A(23), CDKN2C(1), CHEK1(1), CREBBP(14), CUL1(4), DBF4(3), E2F1(5), E2F2(3), E2F3(2), EP300(8), ESPL1(11), FZR1(3), GADD45B(1), GSK3B(2), HDAC1(1), MAD1L1(4), MAD2L2(1), MCM2(8), MCM3(7), MCM4(3), MCM5(2), MCM6(3), MDM2(2), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(2), ORC5L(1), ORC6L(2), PCNA(1), PKMYT1(2), PRKDC(13), PTTG1(1), PTTG2(5), RB1(3), RBL1(5), RBL2(2), SFN(1), SMAD2(1), SMC1A(2), SMC1B(9), TFDP1(1), TGFB2(1), TGFB3(1), TP53(26), WEE1(2), YWHAG(1), YWHAQ(2) 27401543 336 106 316 124 191 25 24 42 52 2 0.00332 1.000 1.000 144 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(1), AKT2(6), AKT3(3), BRAF(78), CAB39(1), EIF4B(1), FIGF(4), HIF1A(1), IGF1(7), MAPK1(3), MAPK3(1), PDPK1(3), PGF(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PRKAA1(1), PRKAA2(18), RICTOR(5), RPS6(1), RPS6KA1(4), RPS6KA2(4), RPS6KA6(5), RPS6KB1(2), RPS6KB2(2), STK11(2), TSC1(3), TSC2(7), ULK1(4), ULK2(5), ULK3(1), VEGFA(1), VEGFB(1), VEGFC(14) 10541941 235 106 170 84 117 13 9 81 15 0 0.0326 1.000 1.000 145 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(3), CADM1(1), CADM3(7), CD2(20), CD22(16), CD226(4), CD274(1), CD276(5), CD34(2), CD4(4), CD40(1), CD40LG(2), CD58(1), CD6(5), CD80(3), CD86(16), CD8A(2), CD8B(6), CD99(1), CDH1(4), CDH15(6), CDH2(10), CDH4(20), CDH5(6), CLDN1(5), CLDN10(3), CLDN11(3), CLDN14(5), CLDN16(4), CLDN17(3), CLDN18(6), CLDN19(2), CLDN2(4), CLDN20(1), CLDN22(1), CLDN4(7), CLDN6(6), CLDN7(1), CLDN8(2), CLDN9(1), CNTN1(15), CNTN2(8), CNTNAP1(7), CNTNAP2(54), CTLA4(1), ESAM(3), F11R(4), GLG1(1), HLA-A(2), HLA-B(4), HLA-C(1), HLA-DMA(2), HLA-DMB(4), HLA-DOA(4), HLA-DOB(1), HLA-DPA1(1), HLA-DQA1(4), HLA-DQA2(2), HLA-DQB1(3), HLA-DRA(7), HLA-DRB1(2), HLA-F(5), HLA-G(3), ICAM1(2), ICAM2(4), ICAM3(2), ICOS(2), ICOSLG(2), ITGA4(26), ITGA6(6), ITGA8(26), ITGA9(9), ITGAL(17), ITGAM(19), ITGAV(5), ITGB1(4), ITGB2(10), ITGB7(4), ITGB8(10), JAM2(9), JAM3(1), L1CAM(5), MADCAM1(1), MAG(11), MPZ(4), MPZL1(1), NCAM1(7), NCAM2(6), NEGR1(3), NEO1(6), NFASC(32), NLGN1(5), NLGN2(5), NLGN3(5), NRCAM(7), NRXN1(33), NRXN2(11), NRXN3(20), OCLN(2), PDCD1(3), PDCD1LG2(1), PTPRC(18), PTPRF(19), PTPRM(5), PVR(3), PVRL1(3), PVRL2(2), PVRL3(2), SDC1(1), SDC2(1), SDC3(3), SDC4(2), SELE(22), SELL(6), SELP(15), SELPLG(4), SIGLEC1(15), SPN(5), VCAM1(13), VCAN(22) 29235161 825 106 792 405 602 62 24 74 63 0 0.00135 1.000 1.000 146 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(1), ATF1(3), BRAF(78), CAMP(1), CREB5(7), CREBBP(14), DAG1(3), EGR1(1), EGR2(4), EGR3(1), EGR4(3), ELK1(1), FRS2(3), GNAQ(1), JUN(1), MAP1B(15), MAP2K4(3), MAP2K7(2), MAPK1(3), MAPK10(6), MAPK3(1), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(6), MAPK9(1), NTRK1(10), OPN1LW(3), PIK3C2G(32), PIK3CA(2), PIK3CD(2), PIK3R1(2), PTPN11(5), SHC1(1), SRC(1), TH(7) 10230910 231 106 167 88 127 12 9 74 9 0 0.0428 1.000 1.000 147 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(1), AKT2(6), AKT3(3), BCL10(1), CARD11(22), CBL(6), CBLB(8), CBLC(12), CD247(2), CD3D(5), CD3E(2), CD4(4), CD40LG(2), CD8A(2), CD8B(6), CDK4(2), CHP(1), CHUK(1), CSF2(2), CTLA4(1), FOS(1), FYN(5), GRAP2(1), GRB2(2), HRAS(1), ICOS(2), IFNG(2), IKBKB(2), IL10(2), IL2(4), IL4(1), IL5(4), ITK(19), JUN(1), KRAS(1), LCK(9), LCP2(5), MALT1(3), MAP3K14(1), NCK2(3), NFAT5(3), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIB(1), NRAS(39), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PAK7(33), PDCD1(3), PDK1(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PLCG1(4), PPP3CA(4), PPP3CB(1), PPP3CC(1), PPP3R2(6), PRKCQ(12), PTPN6(1), PTPRC(18), RASGRP1(7), SOS1(6), SOS2(3), TEC(7), TNF(1), VAV1(13), VAV2(3), VAV3(6), ZAP70(4) 20295607 433 104 386 200 280 31 25 67 30 0 0.0993 1.000 1.000 148 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(1), APC(12), AR(7), BRAF(78), CAMP(1), CCL15(2), CCL16(1), DAG1(3), EGFR(16), GNA11(6), GNA15(2), GNAI1(1), GNAQ(1), ITPKB(5), ITPR1(19), ITPR2(10), ITPR3(4), KCNJ3(14), KCNJ5(6), KCNJ9(4), MAPK1(3), MAPK10(6), MAPK14(4), PHKA2(6), PIK3CA(2), PIK3CD(2), PIK3R1(2), PITX2(1), RAF1(2), SRC(1) 10626575 222 104 158 102 106 17 9 76 14 0 0.338 1.000 1.000 149 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), AKR1C1(2), AKR1C2(2), AKR1C3(6), AKR1C4(4), ALDH1A3(2), ALDH3A1(4), ALDH3B1(2), ALDH3B2(5), CYP1A1(8), CYP1A2(8), CYP1B1(1), CYP2B6(11), CYP2C18(18), CYP2C19(29), CYP2C8(21), CYP2C9(28), CYP2E1(8), CYP2F1(8), CYP2S1(8), CYP3A4(13), CYP3A43(10), CYP3A5(4), CYP3A7(14), DHDH(4), EPHX1(1), GSTA1(5), GSTA2(1), GSTA3(1), GSTA5(2), GSTK1(1), GSTM1(1), GSTM2(2), GSTM3(2), GSTM4(1), GSTM5(3), GSTT1(1), MGST1(1), MGST2(1), UGT1A1(1), UGT1A10(13), UGT1A3(7), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(9), UGT1A8(3), UGT1A9(6), UGT2A1(12), UGT2A3(17), UGT2B10(20), UGT2B11(11), UGT2B15(18), UGT2B28(15), UGT2B4(23), UGT2B7(13) 11436752 500 103 476 217 373 33 22 34 38 0 3.56e-06 1.000 1.000 150 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(12), CD14(4), CD19(5), CD1A(6), CD1B(6), CD1C(13), CD1D(6), CD1E(13), CD2(20), CD22(16), CD33(12), CD34(2), CD36(3), CD37(1), CD38(3), CD3D(5), CD3E(2), CD4(4), CD44(5), CD5(3), CD55(2), CD59(1), CD8A(2), CD8B(6), CR1(35), CR2(20), CSF1(8), CSF1R(9), CSF2(2), CSF2RA(11), CSF3(2), CSF3R(6), DNTT(7), EPO(4), EPOR(1), FCER2(2), FCGR1A(3), FLT3(21), FLT3LG(1), GP5(2), GP9(5), GYPA(4), HLA-DRA(7), HLA-DRB1(2), IL11(2), IL11RA(1), IL1A(3), IL1B(5), IL1R1(7), IL1R2(5), IL2RA(4), IL3(2), IL3RA(4), IL4(1), IL4R(7), IL5(4), IL5RA(7), IL6R(2), IL7(3), IL7R(15), IL9R(4), ITGA1(15), ITGA2(7), ITGA2B(7), ITGA3(4), ITGA4(26), ITGA5(13), ITGA6(6), ITGAM(19), ITGB3(9), KIT(7), KITLG(6), MME(12), MS4A1(4), TFRC(3), THPO(4), TNF(1), TPO(30) 16261398 553 103 528 279 419 27 15 35 57 0 0.0458 1.000 1.000 151 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(2), ACTN2(14), ACTN3(5), ACTN4(3), ARHGAP5(9), BCAR1(3), CD99(1), CDH5(6), CLDN1(5), CLDN10(3), CLDN11(3), CLDN14(5), CLDN16(4), CLDN17(3), CLDN18(6), CLDN19(2), CLDN2(4), CLDN20(1), CLDN22(1), CLDN4(7), CLDN6(6), CLDN7(1), CLDN8(2), CLDN9(1), CTNNA1(2), CTNNA2(17), CTNNA3(19), CTNNB1(6), CTNND1(7), CXCL12(1), CXCR4(1), CYBA(1), CYBB(5), ESAM(3), EZR(1), F11R(4), GNAI1(1), GNAI2(3), GRLF1(3), ICAM1(2), ITGA4(26), ITGAL(17), ITGAM(19), ITGB1(4), ITGB2(10), ITK(19), JAM2(9), JAM3(1), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(4), MLLT4(9), MMP2(3), MMP9(5), MYL2(4), MYL5(1), MYL9(1), MYLPF(1), NCF2(5), NCF4(3), NOX1(7), NOX3(5), OCLN(2), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PLCG1(4), PLCG2(15), PRKCA(8), PRKCG(10), PTK2(3), PTK2B(7), PTPN11(5), PXN(3), RAC1(9), RAP1A(1), RAPGEF3(4), RAPGEF4(8), RASSF5(3), RHOH(4), ROCK1(3), ROCK2(4), SIPA1(5), TXK(6), VASP(1), VAV1(13), VAV2(3), VAV3(6), VCAM1(13), VCL(4) 24704313 521 103 504 267 376 33 11 57 42 2 0.0176 1.000 1.000 152 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(1), AKT2(6), AKT3(3), CASP9(3), CHP(1), HRAS(1), KDR(25), KRAS(1), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(4), MAPK3(1), MAPKAPK2(2), MAPKAPK3(1), NFAT5(3), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), NOS3(13), NRAS(39), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PLA2G12B(3), PLA2G2A(2), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(14), PLA2G4A(8), PLA2G6(7), PLCG1(4), PLCG2(15), PPP3CA(4), PPP3CB(1), PPP3CC(1), PPP3R2(6), PRKCA(8), PRKCG(10), PTGS2(6), PTK2(3), PXN(3), RAC1(9), RAF1(2), SH2D2A(2), SHC2(4), SPHK1(1), SPHK2(5), SRC(1), VEGFA(1) 14420890 326 102 281 131 213 16 19 58 20 0 0.00185 1.000 1.000 153 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(1), AKT2(6), AKT3(3), BTK(8), CSF2(2), FCER1A(8), FCER1G(1), FYN(5), GAB2(1), GRB2(2), HRAS(1), IL13(2), IL3(2), IL4(1), IL5(4), INPP5D(22), KRAS(1), LCP2(5), LYN(3), MAP2K1(7), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP2K7(2), MAPK1(3), MAPK10(6), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(4), MAPK3(1), MAPK9(1), MS4A2(5), NRAS(39), PDK1(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PLA2G12B(3), PLA2G2A(2), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(14), PLA2G4A(8), PLA2G6(7), PLCG1(4), PLCG2(15), PRKCA(8), PRKCD(2), PRKCE(4), RAC1(9), RAF1(2), SOS1(6), SOS2(3), SYK(11), TNF(1), VAV1(13), VAV2(3), VAV3(6) 14445693 339 101 295 125 215 21 24 56 23 0 0.000134 1.000 1.000 154 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), AKT3(3), BCAR1(3), CAPN1(1), CAPN10(6), CAPN11(7), CAPN2(2), CAPN3(6), CAPN5(4), CAPN6(9), CAPN7(1), CAPN9(7), CAPNS1(1), CAV1(1), CRK(2), CSK(1), DOCK1(13), FYN(5), GIT2(3), GRB2(2), ITGA10(4), ITGA11(13), ITGA2(7), ITGA2B(7), ITGA3(4), ITGA4(26), ITGA5(13), ITGA6(6), ITGA7(15), ITGA8(26), ITGA9(9), ITGAD(17), ITGAE(8), ITGAL(17), ITGAM(19), ITGAV(5), ITGAX(14), ITGB1(4), ITGB2(10), ITGB3(9), ITGB4(12), ITGB5(1), ITGB6(8), ITGB7(4), ITGB8(10), MAP2K1(7), MAP2K2(2), MAP2K3(4), MAP2K6(2), MAPK10(6), MAPK12(1), MAPK4(10), MAPK6(3), MAPK7(2), MYLK2(6), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PDPK1(3), PIK3R2(2), PTK2(3), PXN(3), RAC1(9), RAPGEF1(4), RHO(2), ROCK1(3), ROCK2(4), SDCCAG8(2), SEPP1(1), SHC1(1), SHC3(9), SORBS1(8), SOS1(6), SRC(1), TLN1(10), TNS1(5), VASP(1), VAV2(3), VAV3(6), VCL(4), ZYX(4) 26552765 498 99 485 234 363 31 19 51 33 1 0.00289 1.000 1.000 155 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(3), ATM(10), BUB1(1), BUB1B(7), CCNA1(12), CCNB2(1), CCNB3(17), CCND2(4), CCND3(1), CCNE1(3), CCNE2(10), CCNH(1), CDAN1(4), CDC14A(2), CDC14B(1), CDC25A(6), CDC25B(3), CDC25C(3), CDC6(1), CDC7(2), CDH1(4), CDK4(2), CDKN1A(2), CDKN2A(23), CHEK1(1), DTX4(2), E2F1(5), E2F2(3), E2F3(2), EP300(8), ESPL1(11), GSK3B(2), HDAC1(1), HDAC3(3), HDAC4(8), HDAC5(3), HDAC6(2), HDAC8(2), MAD1L1(4), MAD2L2(1), MCM2(8), MCM3(7), MCM4(3), MCM5(2), MCM6(3), MDM2(2), MPEG1(5), MPL(2), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(2), ORC5L(1), ORC6L(2), PCNA(1), PRKDC(13), PTPRA(3), PTTG1(1), PTTG2(5), RB1(3), RBL1(5), TBC1D8(5), TFDP1(1), TP53(26), WEE1(2) 22013395 287 98 269 102 169 24 14 33 45 2 0.000468 1.000 1.000 156 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(1), AKT2(6), AKT3(3), BCL10(1), BLNK(11), BTK(8), CARD11(22), CD19(5), CD22(16), CD72(4), CD79A(1), CD81(2), CHP(1), CHUK(1), CR2(20), FCGR2B(1), FOS(1), GSK3B(2), HRAS(1), IKBKB(2), INPP5D(22), JUN(1), KRAS(1), LILRB3(4), LYN(3), MALT1(3), NFAT5(3), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIB(1), NRAS(39), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PLCG2(15), PPP3CA(4), PPP3CB(1), PPP3CC(1), PPP3R2(6), PTPN6(1), RAC1(9), RASGRP3(8), SYK(11), VAV1(13), VAV2(3), VAV3(6) 14925180 347 98 306 133 219 19 26 55 28 0 0.000505 1.000 1.000 157 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(14), AMY2A(4), AMY2B(7), ENPP1(9), ENPP3(10), G6PC(4), GAA(5), GANAB(5), GBA3(6), GBE1(7), GCK(10), GPI(2), GUSB(3), GYS1(2), GYS2(10), HK1(1), HK2(5), HK3(10), MGAM(89), PGM1(2), PGM3(1), PYGB(2), PYGL(4), PYGM(7), SI(44), UCHL1(4), UCHL3(2), UGT1A1(1), UGT1A10(13), UGT1A3(7), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(9), UGT1A8(3), UGT1A9(6), UGT2B15(18), UGT2B4(23), UXS1(1) 11337037 361 97 342 157 261 33 12 25 30 0 0.00292 1.000 1.000 158 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(21), ASH2L(3), CARM1(4), CTCFL(13), DOT1L(5), EED(3), EHMT1(6), EHMT2(4), EZH1(3), EZH2(6), FBXO11(2), HCFC1(12), JMJD4(3), JMJD6(1), MEN1(2), MLL(23), MLL2(36), MLL3(36), MLL4(23), MLL5(7), NSD1(10), OGT(5), PAXIP1(2), PPP1CA(1), PPP1CB(3), PPP1CC(1), PRDM2(11), PRDM7(2), PRDM9(32), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(7), RBBP5(4), SATB1(10), SETD1A(17), SETD2(10), SETD7(1), SETDB1(1), SETDB2(3), SETMAR(3), STK38(2), SUV39H1(1), SUV420H1(5), SUV420H2(1), SUZ12(2), WHSC1(5), WHSC1L1(5) 23660186 364 96 360 129 242 46 11 37 28 0 0.00575 1.000 1.000 159 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 65 ATM(10), CCNA1(12), CCND1(1), CCND2(4), CCND3(1), CCNE1(3), CCNE2(10), CCNH(1), CDC25A(6), CDK4(2), CDKN1A(2), CDKN1B(1), CDKN2A(23), CDKN2C(1), CREB3L1(3), CREB3L3(6), CREB3L4(2), E2F1(5), E2F2(3), E2F3(2), GBA2(2), MCM2(8), MCM3(7), MCM4(3), MCM5(2), MCM6(3), MDM2(2), MNAT1(2), MYC(2), MYT1(15), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(2), ORC5L(1), ORC6L(2), PCNA(1), POLA2(6), POLE(10), POLE2(1), PRIM1(1), RB1(3), RBL1(5), RPA1(3), RPA2(1), TFDP1(1), TFDP2(3), TNXB(78), TP53(26), WEE1(2) 15890425 294 96 277 112 180 16 9 38 49 2 0.00206 1.000 1.000 160 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 A4GNT(3), ALG1(2), ALG10B(3), ALG12(1), ALG13(4), ALG2(3), ALG3(1), ALG6(2), ALG8(3), ALG9(5), B3GNT1(2), B3GNT2(2), B3GNT7(3), B4GALT1(1), B4GALT2(2), B4GALT3(2), B4GALT5(2), C1GALT1(5), C1GALT1C1(1), CHPF(3), CHST1(7), CHST11(4), CHST12(1), CHST13(2), CHST14(2), CHST2(2), CHST4(8), CHST6(4), CHSY1(5), DDOST(2), DPAGT1(2), EXT1(1), EXT2(3), EXTL1(1), EXTL3(5), FUT11(2), FUT8(5), GALNT1(2), GALNT10(4), GALNT11(1), GALNT12(5), GALNT13(12), GALNT14(16), GALNT2(4), GALNT3(2), GALNT4(2), GALNT5(9), GALNT6(13), GALNT7(5), GALNT8(14), GALNT9(3), GALNTL1(2), GALNTL2(13), GALNTL4(1), GALNTL5(13), GANAB(5), GCNT1(4), GCNT3(3), HS2ST1(1), HS3ST1(8), HS3ST2(6), HS3ST3B1(2), HS3ST5(5), HS6ST1(3), HS6ST2(1), HS6ST3(9), MAN1A1(8), MAN1A2(3), MAN1B1(2), MAN1C1(6), MAN2A1(8), MGAT1(1), MGAT3(9), MGAT4A(5), MGAT5(2), MGAT5B(8), NDST1(3), NDST3(14), NDST4(32), OGT(5), RPN2(2), ST3GAL1(5), ST3GAL4(1), ST6GAL1(4), ST6GALNAC1(3), STT3B(3), WBSCR17(24), XYLT1(8), XYLT2(2) 21863327 432 96 422 227 292 37 13 43 47 0 0.0720 1.000 1.000 161 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(5), ABCA10(13), ABCA12(39), ABCA13(39), ABCA2(7), ABCA3(12), ABCA4(37), ABCA5(4), ABCA6(21), ABCA7(6), ABCA8(24), ABCA9(14), ABCB1(26), ABCB10(2), ABCB11(35), ABCB4(9), ABCB5(26), ABCB6(1), ABCB7(4), ABCB8(2), ABCB9(6), ABCC1(8), ABCC10(10), ABCC11(12), ABCC12(16), ABCC2(7), ABCC3(20), ABCC4(9), ABCC5(5), ABCC6(17), ABCC8(24), ABCC9(40), ABCD2(9), ABCD3(7), ABCD4(1), ABCG1(7), ABCG2(6), ABCG4(5), ABCG5(5), ABCG8(11), CFTR(29), TAP1(1), TAP2(11) 23584184 592 96 571 349 420 44 15 53 60 0 0.0451 1.000 1.000 162 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AKT1(1), AKT2(6), AKT3(3), APAF1(3), ATM(10), BAX(1), BCL2(2), BIRC2(4), BIRC3(6), CAPN1(1), CAPN2(2), CASP10(4), CASP3(1), CASP7(4), CASP8(2), CASP9(3), CFLAR(3), CHP(1), CHUK(1), CSF2RB(14), CYCS(1), DFFA(1), DFFB(2), FAS(3), FASLG(10), IKBKB(2), IL1A(3), IL1B(5), IL1R1(7), IL1RAP(3), IL3(2), IL3RA(4), IRAK2(10), IRAK3(7), IRAK4(2), MAP3K14(1), MYD88(2), NFKB1(3), NFKB2(3), NFKBIA(2), NTRK1(10), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PPP3CA(4), PPP3CB(1), PPP3CC(1), PPP3R2(6), PRKACA(2), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), RELA(2), RIPK1(1), TNF(1), TNFRSF10A(4), TNFRSF10B(1), TNFRSF10C(4), TNFRSF10D(6), TNFRSF1A(2), TNFSF10(5), TP53(26), TRAF2(2) 16652721 285 96 279 146 187 17 15 34 32 0 0.319 1.000 1.000 163 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(1), ACVR1B(3), ACVRL1(4), AKT1(1), AURKB(2), BMPR1A(1), BMPR2(4), BUB1(1), CDKL1(4), CDKL2(2), CDS1(6), CDS2(4), CLK1(3), CLK2(4), COL4A3BP(1), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), DGKA(1), DGKB(16), DGKD(5), DGKE(5), DGKG(10), DGKH(6), DGKQ(3), DGKZ(6), IMPA1(1), INPP1(2), INPP4A(4), INPP5A(3), INPPL1(11), ITPKB(5), MAP3K10(5), MOS(5), NEK1(7), NEK3(1), OCRL(3), PAK4(4), PIK3C2A(4), PIK3C2B(9), PIK3C2G(32), PIK3CA(2), PIK3CB(10), PIK3CG(18), PIM2(1), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), PLCD1(2), PLCG1(4), PLCG2(15), PRKACA(2), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(8), PRKCD(2), PRKCE(4), PRKCG(10), PRKCH(5), PRKCQ(12), PRKCZ(1), PRKD1(2), PRKG1(7), RAF1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA4(2), RPS6KB1(2), STK11(2) 22448583 414 96 397 227 304 24 13 31 42 0 0.398 1.000 1.000 164 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(2), ADCY1(17), ADCY2(6), ADCY3(2), ADCY4(2), ADCY5(9), ADCY6(6), ADCY7(8), ADCY8(30), ADK(3), ADSL(6), ADSS(1), AK1(1), AK2(1), AK5(6), ALLC(5), AMPD1(22), AMPD2(4), AMPD3(16), APRT(1), ATIC(2), ATP1B1(1), ATP5A1(1), ATP5B(1), ATP5C1(1), ATP5F1(6), ATP5H(1), CANT1(8), DGUOK(4), ENPP1(9), ENPP3(10), ENTPD1(5), ENTPD2(4), FHIT(2), GART(7), GDA(6), GMPS(3), GUCY1A2(11), GUCY1A3(20), GUCY1B3(4), GUCY2C(20), GUCY2D(3), GUCY2F(10), GUK1(1), IMPDH2(1), NPR1(13), NPR2(12), NT5E(4), NT5M(1), PAPSS1(2), PAPSS2(4), PDE1A(22), PDE4A(3), PDE4B(6), PDE4C(11), PDE4D(5), PDE5A(5), PDE6B(11), PDE6C(18), PDE6G(2), PDE7B(12), PDE8A(2), PDE9A(6), PFAS(5), PKLR(6), PKM2(5), POLD1(3), POLD2(2), POLE(10), POLG(4), POLL(7), POLQ(15), POLR1B(5), POLR2A(10), POLR2B(11), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(1), PRPS1(1), PRPS1L1(8), PRPS2(1), PRUNE(1), RRM1(3) 25580381 533 96 510 271 376 38 14 51 54 0 0.00889 1.000 1.000 165 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(1), AKT2(6), AKT3(3), CASP8(2), CD14(4), CD40(1), CD80(3), CD86(16), CHUK(1), CXCL10(2), CXCL11(1), CXCL9(2), FOS(1), IFNA10(2), IFNA14(6), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(3), IFNAR1(1), IFNAR2(5), IFNB1(5), IKBKB(2), IKBKE(7), IL12A(2), IL12B(3), IL1B(5), IL8(1), IRAK4(2), IRF3(3), IRF5(2), IRF7(5), JUN(1), LBP(6), LY96(3), MAP2K1(7), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP2K7(2), MAPK1(3), MAPK10(6), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(4), MAPK3(1), MAPK9(1), MYD88(2), NFKB1(3), NFKB2(3), NFKBIA(2), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), RAC1(9), RELA(2), RIPK1(1), SPP1(4), STAT1(2), TBK1(2), TICAM1(6), TLR1(7), TLR2(10), TLR3(7), TLR4(26), TLR5(14), TLR6(3), TLR7(6), TLR8(5), TLR9(8), TNF(1), TOLLIP(1), TRAF3(3), TRAF6(2) 17927940 342 95 330 167 234 25 14 44 25 0 0.0350 1.000 1.000 166 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(3), BRAF(78), CREB5(7), DUSP4(1), DUSP6(1), DUSP9(1), EEF2K(2), GRB2(2), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK3(1), MKNK1(5), MKNK2(2), MOS(5), NFKB1(3), RAP1A(1), RPS6KA1(4), RPS6KA2(4), SHC1(1), SOS1(6), SOS2(3), TRAF3(3) 5895406 145 95 80 47 61 7 4 69 4 0 0.139 1.000 1.000 167 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 IMPA1(1), IMPA2(2), INPP1(2), INPP4A(4), INPP5A(3), INPP5B(4), INPPL1(11), IPMK(2), ISYNA1(1), ITPK1(5), ITPKB(5), MIOX(3), OCRL(3), PI4KA(9), PI4KB(3), PIK3C3(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(6), PIP5K1B(15), PIP5K1C(4), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), PLCD1(2), PLCD3(2), PLCD4(1), PLCE1(27), PLCG1(4), PLCG2(15), PLCZ1(13), PTEN(12), SYNJ1(11), SYNJ2(11) 14754171 305 94 295 148 217 17 15 28 28 0 0.0404 1.000 1.000 168 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), AGK(4), AGPAT2(3), AGPAT3(3), AGPAT4(5), AGPAT6(2), AKR1A1(1), AKR1B1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2), CEL(6), DAK(2), DGAT2(2), DGKA(1), DGKB(16), DGKD(5), DGKE(5), DGKG(10), DGKH(6), DGKI(14), DGKQ(3), DGKZ(6), GK(5), GK2(21), GLA(1), GLB1(5), GPAM(5), LCT(31), LIPA(1), LIPC(6), LIPF(12), LIPG(5), LPL(2), MGLL(3), PNLIP(5), PNLIPRP1(9), PNLIPRP2(2), PNPLA3(1), PPAP2B(4), PPAP2C(6) 11791742 315 93 296 137 222 27 13 29 24 0 0.00129 1.000 1.000 169 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(4), AKR1D1(14), ARSD(2), ARSE(4), CARM1(4), CYP11B1(8), CYP11B2(9), CYP19A1(8), HEMK1(1), HSD11B1(8), HSD17B12(1), HSD17B2(7), HSD17B3(5), HSD3B1(4), HSD3B2(9), LCMT1(4), METTL2B(6), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(7), SRD5A1(2), SRD5A2(5), STS(3), SULT1E1(10), SULT2A1(4), SULT2B1(6), UGT1A1(1), UGT1A10(13), UGT1A3(7), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(9), UGT1A8(3), UGT1A9(6), UGT2A1(12), UGT2A3(17), UGT2B10(20), UGT2B11(11), UGT2B15(18), UGT2B28(15), UGT2B4(23), UGT2B7(13), WBSCR22(1) 9971427 328 92 315 133 224 31 15 23 35 0 9.08e-05 1.000 1.000 170 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(3), ACADL(2), ACADM(5), ACOX1(3), ACOX2(7), ACOX3(5), ACSL1(3), ACSL3(3), ACSL5(13), ACSL6(6), ADIPOQ(3), ANGPTL4(4), APOA1(2), APOA5(4), AQP7(3), CD36(3), CPT1A(7), CPT1B(6), CPT1C(12), CPT2(1), CYP27A1(2), CYP4A11(14), CYP4A22(17), CYP7A1(5), CYP8B1(6), EHHADH(5), FABP1(3), FABP2(5), FABP3(1), FABP4(1), FADS2(2), GK(5), GK2(21), HMGCS2(14), LPL(2), ME1(14), MMP1(6), NR1H3(2), OLR1(3), PCK1(20), PCK2(3), PDPK1(3), PPARA(4), PPARD(2), PPARG(8), RXRA(1), RXRB(1), RXRG(3), SCD(2), SLC27A1(3), SLC27A2(7), SLC27A4(4), SLC27A5(4), SLC27A6(19), SORBS1(8), UBC(4), UCP1(4) 13165611 323 92 311 179 243 27 12 18 22 1 0.149 1.000 1.000 171 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(3), ACTB(4), ACTG1(4), ACTN1(2), ACTN2(14), ACTN3(5), ACTN4(3), ACVR1B(3), ACVR1C(7), BAIAP2(3), CDH1(4), CREBBP(14), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(17), CTNNA3(19), CTNNB1(6), CTNND1(7), EGFR(16), EP300(8), ERBB2(3), FARP2(2), FER(1), FGFR1(7), FYN(5), IGF1R(6), INSR(13), IQGAP1(7), LEF1(1), LMO7(20), MAPK1(3), MAPK3(1), MET(12), MLLT4(9), NLK(4), PARD3(10), PTPN1(2), PTPN6(1), PTPRB(59), PTPRF(19), PTPRJ(5), PTPRM(5), PVRL1(3), PVRL2(2), PVRL3(2), PVRL4(6), RAC1(9), SMAD2(1), SNAI1(1), SNAI2(1), SORBS1(8), SRC(1), SSX2IP(3), TCF7(1), TCF7L1(1), TCF7L2(4), TGFBR2(5), TJP1(9), VCL(4), WAS(5), WASF1(1), WASF2(4), WASF3(11), WASL(3), YES1(3) 24080836 427 92 408 223 308 26 9 37 44 3 0.379 1.000 1.000 172 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(7), AGTR2(3), ATP8A1(13), AVPR1A(3), AVPR1B(5), BDKRB1(5), BDKRB2(2), BRS3(2), C3AR1(3), CCKAR(9), CCKBR(8), CCR1(5), CCR10(2), CCR2(8), CCR3(8), CCR4(5), CCR5(5), CCR6(1), CCR7(3), CCR8(2), CX3CR1(10), CXCR3(2), CXCR4(1), CXCR6(4), EDNRA(4), EDNRB(4), FPR1(15), FSHR(12), GALR1(3), GALT(2), GHSR(6), GNB2L1(2), GNRHR(2), GPR77(3), GRPR(3), LHCGR(14), MC2R(3), MC3R(6), MC4R(1), MC5R(5), NMBR(3), NPY1R(12), NPY2R(8), NPY5R(12), NTSR1(4), NTSR2(2), OPRK1(15), OPRL1(5), OPRM1(4), OXTR(3), PPYR1(10), SSTR1(7), SSTR2(2), SSTR3(10), SSTR4(1), TACR1(5), TACR2(3), TACR3(17), TRHR(13), TSHR(7) 10487135 344 92 334 258 245 27 13 32 27 0 0.0745 1.000 1.000 173 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(1), ACVR1B(3), ACVR1C(7), ACVR2A(3), ACVR2B(1), ACVRL1(4), AMHR2(9), BMP2(4), BMP4(2), BMP5(12), BMP6(8), BMP7(2), BMPR1A(1), BMPR1B(2), BMPR2(4), CHRD(8), COMP(5), CREBBP(14), CUL1(4), DCN(14), EP300(8), FST(3), GDF5(9), GDF6(1), GDF7(2), ID2(2), IFNG(2), INHBA(12), INHBB(4), INHBC(6), INHBE(2), LEFTY1(4), LEFTY2(1), LTBP1(28), MAPK1(3), MAPK3(1), MYC(2), NODAL(2), NOG(1), PITX2(1), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(2), PPP2R2B(3), PPP2R2C(4), RBL1(5), RBL2(2), ROCK1(3), ROCK2(4), RPS6KB1(2), RPS6KB2(2), SMAD1(4), SMAD2(1), SMAD5(3), SMAD6(5), SMAD9(8), SMURF1(1), SMURF2(5), SP1(4), TFDP1(1), TGFB2(1), TGFB3(1), TGFBR2(5), THBS1(19), THBS2(8), THBS3(7), THBS4(7), TNF(1), ZFYVE16(3), ZFYVE9(5) 19888619 325 91 320 180 217 33 15 27 33 0 0.753 1.000 1.000 174 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(3), ATM(10), ATR(13), BAI1(11), BAX(1), CASP3(1), CASP8(2), CASP9(3), CCNB2(1), CCNB3(17), CCND1(1), CCND2(4), CCND3(1), CCNE1(3), CCNE2(10), CCNG1(1), CDK4(2), CDK6(1), CDKN1A(2), CDKN2A(23), CHEK1(1), CYCS(1), DDB2(2), EI24(1), FAS(3), GADD45B(1), GTSE1(5), IGF1(7), IGFBP3(1), LRDD(3), MDM2(2), MDM4(1), PERP(1), PPM1D(2), PTEN(12), RFWD2(3), RRM2B(1), SERPINB5(8), SERPINE1(2), SESN2(3), SESN3(1), SFN(1), STEAP3(3), THBS1(19), TNFRSF10B(1), TP53(26), TP73(4), TSC2(7), ZMAT3(1) 12992063 233 90 215 100 128 10 16 31 48 0 0.109 1.000 1.000 175 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(33), COL4A2(20), COL4A3(24), COL4A4(58), COL4A5(41), COL4A6(28), F10(4), F11(9), F12(1), F2(6), F2R(4), F5(20), F8(29), F9(6), FGA(20), FGB(7), FGG(4), KLKB1(16), PROC(7), PROS1(9), SERPINC1(5), SERPING1(8) 8889442 359 89 349 116 286 21 14 22 16 0 0.176 1.000 1.000 176 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(10), ALG6(2), CCKBR(8), CCR2(8), CCR3(8), CCR5(5), CELSR1(21), CELSR2(19), CELSR3(20), CHRM2(10), CHRM3(11), CXCR3(2), DRD4(1), EDNRA(4), EMR2(1), EMR3(15), F2R(4), FSHR(12), GHRHR(4), GNRHR(2), GPR116(25), GPR132(3), GPR133(8), GPR143(2), GPR17(1), GPR18(1), GPR55(4), GPR56(3), GPR61(4), GPR77(3), GPR84(6), GRM1(9), GRPR(3), HRH4(4), LGR6(9), LPHN2(24), LPHN3(10), NTSR1(4), OR2M4(10), OR8G2(6), P2RY13(3), PTGFR(13), SMO(6), SSTR2(2), TAAR5(1), TSHR(7) 13314060 338 88 330 237 229 28 12 43 25 1 0.450 1.000 1.000 177 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(1), AKT2(6), AKT3(3), BCR(6), BTK(8), CD19(5), CDKN2A(23), DAPP1(4), FLOT1(1), GAB1(3), ITPR1(19), ITPR2(10), ITPR3(4), LYN(3), NR0B2(6), PDK1(1), PIK3CA(2), PITX2(1), PLCG2(15), PPP1R13B(5), PREX1(3), PTEN(12), PTPRC(18), RPS6KA1(4), RPS6KA2(4), RPS6KB1(2), SAG(5), SYK(11), TEC(7), VAV1(13) 11016881 205 87 188 109 128 14 11 14 38 0 0.209 1.000 1.000 178 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ABP1(11), ACAT2(1), ACMSD(7), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), AOC2(5), AOC3(6), AOX1(15), ASMT(4), CAT(4), CYP19A1(8), CYP1A1(8), CYP1A2(8), CYP2A13(6), CYP2A6(9), CYP2A7(6), CYP2B6(11), CYP2C18(18), CYP2C19(29), CYP2C8(21), CYP2C9(28), CYP2D6(1), CYP2E1(8), CYP2F1(8), CYP2J2(4), CYP3A4(13), CYP3A5(4), CYP3A7(14), CYP4B1(11), CYP4F8(7), CYP51A1(1), DDC(7), EHHADH(5), GCDH(3), HAAO(3), HADHA(7), KMO(5), KYNU(6), MAOA(2), MAOB(7), TDO2(2), TPH1(2), WARS(3), WARS2(1) 10978483 356 87 343 213 286 21 13 17 19 0 0.148 1.000 1.000 179 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(3), ACAA2(1), ACADL(2), ACADM(5), ACADS(2), ACADSB(3), ACADVL(1), ACAT2(1), ACOX1(3), ACOX3(5), ACSL1(3), ACSL3(3), ACSL5(13), ACSL6(6), ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2), CPT1A(7), CPT1B(6), CPT1C(12), CPT2(1), CYP4A11(14), CYP4A22(17), DCI(2), EHHADH(5), GCDH(3), HADHA(7), HADHB(2), HSD17B10(1), HSD17B4(3), PECI(1) 9867300 227 86 216 102 170 17 11 15 13 1 0.0144 1.000 1.000 180 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(1), CDC40(4), CLK2(4), COL2A1(18), CPSF1(5), CPSF2(1), CPSF3(2), CSTF1(5), CSTF2(3), CSTF2T(3), CSTF3(4), DDIT3(1), DDX20(7), DHX15(3), DHX16(6), DHX38(5), DHX8(5), DHX9(6), DICER1(13), DNAJC8(2), GIPC1(3), LOC440563(14), LSM7(1), METTL3(1), NCBP1(1), NONO(6), NUDT21(2), NXF1(2), PABPN1(1), PAPOLA(3), POLR2A(10), PRPF18(2), PRPF3(2), PRPF4(3), PRPF4B(3), PRPF8(10), PSKH1(2), PTBP1(1), PTBP2(5), RBM17(1), RBM5(5), RNGTT(1), RNMT(6), SF3A1(5), SF3A2(2), SF3A3(2), SF3B1(8), SF3B2(6), SF3B4(4), SF4(4), SFRS12(2), SFRS14(8), SFRS16(5), SFRS5(1), SFRS6(2), SFRS8(1), SFRS9(2), SNRPA(1), SNRPA1(1), SNRPB(4), SNRPB2(1), SNRPE(1), SNRPN(4), SNURF(2), SPOP(2), SRPK1(4), SRPK2(2), SRRM1(6), SUPT5H(4), TXNL4A(1), U2AF2(2), XRN2(4) 21354684 274 86 274 111 186 22 14 31 21 0 0.127 1.000 1.000 181 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(1), AKT2(6), AKT3(3), CDKN1B(1), CDKN2A(23), CREB5(7), ERBB4(30), F2RL2(4), GAB1(3), GRB2(2), GSK3B(2), IFI27(2), IGF1(7), IGFBP1(2), INPPL1(11), IRS1(3), IRS2(1), IRS4(7), MET(12), MYC(2), NOLC1(2), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PAK7(33), PARD3(10), PDK1(1), PIK3CA(2), PIK3CD(2), PPP1R13B(5), PREX1(3), PTEN(12), PTK2(3), PTPN1(2), RPS6KA1(4), RPS6KA2(4), RPS6KB1(2), SFN(1), SHC1(1), SLC2A4(6), SOS1(6), SOS2(3), TSC1(3), TSC2(7), YWHAG(1), YWHAQ(2) 15478380 259 86 244 126 152 24 12 26 45 0 0.270 1.000 1.000 182 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(11), ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), ALDH1A3(2), ALDH3A1(4), ALDH3B1(2), ALDH3B2(5), AOC2(5), AOC3(6), AOX1(15), CARM1(4), COMT(2), DBH(5), DCT(2), DDC(7), ECH1(1), FAH(4), GOT1(4), GOT2(2), HEMK1(1), HGD(11), HPD(3), LCMT1(4), MAOA(2), MAOB(7), METTL2B(6), MYST3(10), MYST4(11), NAT6(2), PNMT(4), PNPLA3(1), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(7), SH3GLB1(2), TAT(12), TH(7), TPO(30), TYR(5), TYRP1(5), WBSCR22(1) 11901391 303 85 291 158 228 26 15 22 12 0 0.129 1.000 1.000 183 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(7), ADCY4(2), ADCY6(6), ADCY8(30), CACNA1A(22), CACNA1B(20), GNAS(12), GNAT3(3), GNB3(5), GRM4(15), ITPR3(4), KCNB1(18), PDE1A(22), PLCB2(7), PRKACA(2), PRKACB(2), PRKACG(7), PRKX(1), SCNN1A(5), SCNN1B(12), SCNN1G(18), TAS1R1(7), TAS1R2(13), TAS1R3(1), TAS2R1(5), TAS2R10(6), TAS2R13(2), TAS2R14(1), TAS2R16(5), TAS2R38(12), TAS2R39(7), TAS2R4(2), TAS2R40(3), TAS2R41(8), TAS2R46(1), TAS2R5(2), TAS2R60(13), TAS2R7(2), TAS2R8(3), TAS2R9(4), TRPM5(9) 11325411 326 85 311 272 231 21 10 34 30 0 0.875 1.000 1.000 184 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(4), BCL2(2), CABIN1(3), CALM2(1), CAMK2B(2), CAMK4(9), CD3E(2), CD69(4), CDKN1A(2), CNR1(7), CREBBP(14), CSF2(2), CSNK2A1(1), CSNK2B(1), CTLA4(1), EGR2(4), EGR3(1), EP300(8), FCER1A(8), FCGR3A(5), FOS(1), GATA3(8), GATA4(2), GRLF1(3), GSK3B(2), HRAS(1), ICOS(2), IFNB1(5), IFNG(2), IL10(2), IL13(2), IL1B(5), IL2(4), IL2RA(4), IL3(2), IL4(1), IL8(1), ITK(19), KPNA5(1), MAP2K7(2), MAPK14(4), MAPK9(1), MEF2A(2), MEF2B(2), MEF2D(2), MYF5(8), NCK2(3), NFAT5(3), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), NFKB2(3), NFKBIB(1), NPPB(4), NUP214(10), P2RX7(3), PAK1(2), PIN1(1), PPIA(1), PPP3CB(1), PPP3CC(1), PTPRC(18), RELA(2), RPL13A(1), SFN(1), SLA(1), SP1(4), SP3(1), TNF(1), TRAF2(2), TRPV6(22), VAV1(13), VAV2(3), VAV3(6), XPO5(6) 18241661 313 84 303 155 232 24 12 20 25 0 0.0978 1.000 1.000 185 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(9), CAD(12), CANT1(8), CDA(2), CTPS(2), CTPS2(2), DCTD(1), DHODH(1), DPYD(38), DPYS(15), ENTPD1(5), ENTPD3(3), ENTPD4(3), ENTPD5(1), ENTPD6(3), ENTPD8(1), NME6(1), NME7(4), NT5C1A(1), NT5C1B(16), NT5C2(1), NT5C3(2), NT5E(4), NT5M(1), PNPT1(1), POLA1(1), POLA2(6), POLD1(3), POLD2(2), POLD3(3), POLE(10), POLE2(1), POLR1A(7), POLR1B(5), POLR1C(1), POLR2A(10), POLR2B(11), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(2), POLR3B(12), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(8), RRM1(3), RRM2B(1), TK2(1), TXNRD1(3), TXNRD2(2), TYMS(1), UCK1(2), UMPS(1), UPB1(5), UPP2(5) 16242748 253 83 243 121 163 24 13 32 21 0 0.101 1.000 1.000 186 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(14), ACSL1(3), ACSL3(3), ACSL5(13), ACSL6(6), ADIPOQ(3), ADIPOR1(3), ADIPOR2(1), AKT1(1), AKT2(6), AKT3(3), CAMKK1(1), CAMKK2(4), CD36(3), CHUK(1), CPT1A(7), CPT1B(6), CPT1C(12), CPT2(1), G6PC(4), G6PC2(2), IKBKB(2), IRS1(3), IRS2(1), IRS4(7), JAK1(4), JAK2(6), JAK3(5), LEP(1), LEPR(13), MAPK10(6), MAPK9(1), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIB(1), NPY(2), PCK1(20), PCK2(3), POMC(3), PPARA(4), PPARGC1A(15), PRKAA1(1), PRKAA2(18), PRKAB2(1), PRKAG1(2), PRKAG2(3), PRKAG3(7), PRKCQ(12), PTPN11(5), RELA(2), RXRA(1), RXRB(1), RXRG(3), SLC2A1(3), SLC2A4(6), SOCS3(2), STAT3(6), STK11(2), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(2), TYK2(4) 16630103 287 83 282 176 197 32 15 18 25 0 0.656 1.000 1.000 187 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(3), BAX(1), BTK(8), CAD(12), CASP10(4), CASP3(1), CASP8(2), CASP8AP2(3), CDK2AP1(2), CSNK1A1(2), DAXX(5), DEDD(1), DEDD2(3), DFFA(1), DIABLO(1), EGFR(16), EPHB2(17), FAF1(3), FAIM2(5), HSPB1(2), IL1A(3), IL8(1), MAP2K4(3), MAP2K7(2), MAP3K5(11), MAPK1(3), MAPK10(6), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(6), MAPK9(1), MET(12), NFAT5(3), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NR0B2(6), PTPN13(8), RALBP1(2), RIPK1(1), ROCK1(3), SMPD1(1), TNFRSF6B(2), TP53(26), TPX2(8), TRAF2(2), TUFM(2) 14548230 223 83 218 125 148 12 13 27 23 0 0.651 1.000 1.000 188 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(3), AGT(3), AKT1(1), CALM2(1), CAMK1(4), CAMK1G(9), CAMK4(9), CREBBP(14), CSNK1A1(2), EDN1(7), ELSPBP1(1), F2(6), FGF2(1), FKBP1A(2), GATA4(2), GSK3B(2), HAND2(4), HRAS(1), IGF1(7), LIF(1), MAP2K1(7), MAPK1(3), MAPK14(4), MAPK3(1), MEF2C(2), MYH2(53), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), NPPA(1), PIK3CA(2), PIK3R1(2), PPP3CA(4), PPP3CB(1), PPP3CC(1), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), RAF1(2), RPS6KB1(2), SYT1(12) 10182603 224 82 216 129 172 17 9 14 12 0 0.571 1.000 1.000 189 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), AGPAT2(3), AGPAT3(3), AGPAT4(5), AKR1A1(1), AKR1B1(2), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), CEL(6), DGKA(1), DGKB(16), DGKD(5), DGKE(5), DGKG(10), DGKH(6), DGKQ(3), DGKZ(6), GK(5), GLA(1), GLB1(5), LCT(31), LIPC(6), LIPF(12), LIPG(5), LPL(2), PNLIP(5), PNLIPRP1(9), PNLIPRP2(2), PPAP2B(4), PPAP2C(6) 9670439 269 81 254 121 195 25 10 21 18 0 0.00395 1.000 1.000 190 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(1), APH1A(1), CREBBP(14), CTBP2(1), DLL1(2), DLL3(5), DLL4(5), DTX1(6), DTX2(3), DTX3(2), DTX3L(5), DTX4(2), DVL2(3), DVL3(5), EP300(8), HDAC1(1), HES1(1), JAG1(5), JAG2(4), LFNG(3), MAML1(2), MAML2(2), MAML3(6), MFNG(5), NCOR2(15), NCSTN(3), NOTCH1(4), NOTCH2(25), NOTCH3(16), NOTCH4(38), NUMB(2), NUMBL(3), PSEN1(1), PSEN2(2), PTCRA(1), RBPJ(2), RBPJL(1), SNW1(2) 13746540 207 81 207 120 120 23 8 39 17 0 0.919 1.000 1.000 191 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(3), AKT1(1), BDKRB2(2), CALM2(1), CAV1(1), CHRM1(4), CHRNA1(3), FLT1(21), FLT4(19), KDR(25), NOS3(13), PDE2A(11), PDE3A(14), PDE3B(5), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKG1(7), PRKG2(10), RYR2(54), SLC7A1(2), SYT1(12), TNNI1(1) 8146883 226 80 215 139 168 16 7 16 18 1 0.483 1.000 1.000 192 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(5), AGT(3), AGTR1(7), AGTR2(3), CMA1(4), COL4A1(33), COL4A2(20), COL4A3(24), COL4A4(58), COL4A5(41), COL4A6(28), REN(8) 5047818 234 79 227 76 198 11 5 9 11 0 0.766 1.000 1.000 193 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS2(3), ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), AKR1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH3B1(2), ALDH3B2(5), ALDH7A1(3), ALDH9A1(2), ALDOA(1), ALDOB(8), ALDOC(1), BPGM(1), DLAT(2), DLD(1), ENO1(2), ENO3(2), FBP1(1), FBP2(1), G6PC(4), G6PC2(2), GALM(2), GCK(10), GPI(2), HK1(1), HK2(5), HK3(10), LDHA(2), LDHAL6A(1), LDHAL6B(6), LDHC(3), PDHA1(1), PDHA2(9), PDHB(1), PFKL(2), PGK1(2), PGK2(17), PGM1(2), PGM3(1), PKLR(6), PKM2(5) 11669876 220 79 208 105 163 14 11 15 17 0 0.00449 1.000 1.000 194 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(3), ACTB(4), ACTG1(4), ARHGEF2(9), CD14(4), CDH1(4), CLDN1(5), CTNNB1(6), CTTN(1), EZR(1), FYN(5), HCLS1(7), ITGB1(4), KRT18(2), LY96(3), NCK2(3), NCL(4), OCLN(2), PRKCA(8), ROCK1(3), ROCK2(4), TLR4(26), TLR5(14), TUBA1A(1), TUBA1B(3), TUBA1C(2), TUBA3C(12), TUBA3D(9), TUBA3E(1), TUBA4A(4), TUBA8(1), TUBAL3(8), TUBB1(2), TUBB2A(2), TUBB3(3), TUBB4(1), TUBB4Q(5), TUBB6(6), TUBB8(7), WAS(5), WASL(3), YWHAQ(2) 10509837 203 79 193 88 144 18 6 20 15 0 0.00958 1.000 1.000 195 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(3), ACTB(4), ACTG1(4), ARHGEF2(9), CD14(4), CDH1(4), CLDN1(5), CTNNB1(6), CTTN(1), EZR(1), FYN(5), HCLS1(7), ITGB1(4), KRT18(2), LY96(3), NCK2(3), NCL(4), OCLN(2), PRKCA(8), ROCK1(3), ROCK2(4), TLR4(26), TLR5(14), TUBA1A(1), TUBA1B(3), TUBA1C(2), TUBA3C(12), TUBA3D(9), TUBA3E(1), TUBA4A(4), TUBA8(1), TUBAL3(8), TUBB1(2), TUBB2A(2), TUBB3(3), TUBB4(1), TUBB4Q(5), TUBB6(6), TUBB8(7), WAS(5), WASL(3), YWHAQ(2) 10509837 203 79 193 88 144 18 6 20 15 0 0.00958 1.000 1.000 196 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(3), ACP2(2), ACP5(3), ACPP(6), ALPI(3), ALPL(6), ALPP(6), ALPPL2(7), CYP19A1(8), CYP1A1(8), CYP1A2(8), CYP2A13(6), CYP2A6(9), CYP2A7(6), CYP2B6(11), CYP2C18(18), CYP2C19(29), CYP2C8(21), CYP2C9(28), CYP2D6(1), CYP2E1(8), CYP2F1(8), CYP2J2(4), CYP3A4(13), CYP3A5(4), CYP3A7(14), CYP4B1(11), CYP4F8(7), CYP51A1(1), PON1(12) 5819064 271 78 257 159 221 13 9 9 19 0 0.0208 1.000 1.000 197 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP1(2), INPP4A(4), INPP5A(3), INPPL1(11), ITPKB(5), MIOX(3), OCRL(3), PIK3C2A(4), PIK3C2B(9), PIK3C2G(32), PIK3CA(2), PIK3CB(10), PIK3CG(18), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), PLCD1(2), PLCG1(4), PLCG2(15) 8930739 212 78 201 98 155 10 8 16 23 0 0.0383 1.000 1.000 198 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(2), AKT1(1), AKT2(6), AKT3(3), ANGPTL2(2), ARHGAP1(1), ARHGAP4(1), ARHGEF11(10), BTK(8), CFL1(1), GDI2(1), INPPL1(11), ITPR1(19), ITPR2(10), ITPR3(4), LIMK1(4), MYLK(22), MYLK2(6), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PAK7(33), PDK1(1), PIK3CA(2), PIK3CD(2), PIK3CG(18), PIK3R1(2), PITX2(1), PPP1R13B(5), PTEN(12), RACGAP1(1), RHO(2), ROCK1(3), ROCK2(4), SAG(5), WASF1(1), WASL(3) 13989472 222 78 217 105 150 21 10 22 19 0 0.0598 1.000 1.000 199 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(1), AKT2(6), AKT3(3), BRD4(16), CBL(6), CDKN2A(23), F2RL2(4), FLOT1(1), GRB2(2), GSK3B(2), IGFBP1(2), INPPL1(11), IRS1(3), IRS2(1), IRS4(7), LNPEP(9), MAPK1(3), MAPK3(1), PARD3(10), PDK1(1), PIK3CA(2), PIK3CD(2), PIK3R1(2), PPYR1(10), PTEN(12), PTPN1(2), RAF1(2), RPS6KA1(4), RPS6KA2(4), RPS6KB1(2), SERPINB6(2), SFN(1), SHC1(1), SLC2A4(6), SORBS1(8), SOS1(6), SOS2(3), YWHAG(1), YWHAQ(2) 11952644 184 78 174 82 98 19 10 19 38 0 0.205 1.000 1.000 200 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(1), ATF2(5), DLD(1), DUSP10(6), DUSP4(1), DUSP8(1), GAB1(3), GCK(10), IL1R1(7), JUN(1), MAP2K4(3), MAP2K5(2), MAP2K7(2), MAP3K10(5), MAP3K11(4), MAP3K12(3), MAP3K13(5), MAP3K2(4), MAP3K3(4), MAP3K4(11), MAP3K5(11), MAP3K9(17), MAPK10(6), MAPK7(2), MAPK9(1), NFATC3(6), NR2C2(2), PAPPA(39), SHC1(1), TP53(26), TRAF6(2), ZAK(5) 10069099 197 78 192 80 139 16 7 17 18 0 0.0941 1.000 1.000 201 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), AKR1A1(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH3B1(2), ALDH3B2(5), ALDH9A1(2), ALDOA(1), ALDOB(8), ALDOC(1), BPGM(1), DLAT(2), DLD(1), ENO1(2), ENO3(2), FBP1(1), FBP2(1), G6PC(4), GCK(10), GPI(2), HK1(1), HK2(5), HK3(10), LDHA(2), LDHC(3), PDHA1(1), PDHA2(9), PDHB(1), PGK1(2), PGM1(2), PGM3(1), PKLR(6), PKM2(5) 9795600 196 77 187 87 142 16 9 15 14 0 0.00221 1.000 1.000 202 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), AKR1A1(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH3B1(2), ALDH3B2(5), ALDH9A1(2), ALDOA(1), ALDOB(8), ALDOC(1), BPGM(1), DLAT(2), DLD(1), ENO1(2), ENO3(2), FBP1(1), FBP2(1), G6PC(4), GCK(10), GPI(2), HK1(1), HK2(5), HK3(10), LDHA(2), LDHC(3), PDHA1(1), PDHA2(9), PDHB(1), PGK1(2), PGM1(2), PGM3(1), PKLR(6), PKM2(5) 9795600 196 77 187 87 142 16 9 15 14 0 0.00221 1.000 1.000 203 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(4), CANX(1), CD4(4), CD74(3), CD8A(2), CD8B(6), CIITA(10), CTSS(3), HLA-A(2), HLA-B(4), HLA-C(1), HLA-DMA(2), HLA-DMB(4), HLA-DOA(4), HLA-DOB(1), HLA-DPA1(1), HLA-DQA1(4), HLA-DQA2(2), HLA-DQB1(3), HLA-DRA(7), HLA-DRB1(2), HLA-F(5), HLA-G(3), HSP90AA1(2), HSP90AB1(4), HSPA5(4), IFI30(1), IFNA10(2), IFNA14(6), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(3), KIR2DL1(13), KIR2DL3(4), KIR2DL4(3), KIR2DS4(12), KIR3DL1(15), KIR3DL2(2), KIR3DL3(1), KLRC1(2), KLRC2(1), KLRC3(5), KLRC4(4), KLRD1(4), LGMN(4), LTA(2), NFYA(1), NFYB(1), PDIA3(2), PSME2(4), RFX5(4), RFXANK(1), TAP1(1), TAP2(11), TAPBP(1) 9226657 218 77 214 124 149 22 8 17 22 0 0.321 1.000 1.000 204 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(6), ALOX12(4), ALOX12B(6), ALOX15(4), ALOX15B(5), ALOX5(8), CYP2B6(11), CYP2C18(18), CYP2C19(29), CYP2C8(21), CYP2C9(28), CYP2E1(8), CYP2J2(4), CYP4A11(14), CYP4A22(17), CYP4F2(7), CYP4F3(17), EPHX2(4), GGT1(4), GPX1(2), GPX3(2), GPX5(6), GPX6(7), LTA4H(2), PLA2G12B(3), PLA2G2A(2), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(14), PLA2G4A(8), PLA2G6(7), PTGDS(2), PTGIS(9), PTGS1(14), PTGS2(6), TBXAS1(8) 7735662 316 76 306 212 249 22 6 18 20 1 0.391 1.000 1.000 205 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(11), ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), ALDH1A3(2), ALDH3A1(4), ALDH3B1(2), ALDH3B2(5), AOC2(5), AOC3(6), AOX1(15), COMT(2), DBH(5), DCT(2), DDC(7), FAH(4), GOT1(4), GOT2(2), HGD(11), HPD(3), MAOA(2), MAOB(7), PNMT(4), TAT(12), TH(7), TPO(30), TYR(5) 6325956 235 76 225 121 186 16 12 13 8 0 0.0229 1.000 1.000 206 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(12), AXIN1(6), CCND1(1), CCND2(4), CCND3(1), CSNK1E(3), CTNNB1(6), DVL2(3), DVL3(5), FBXW2(1), FZD1(1), FZD10(1), FZD2(4), FZD5(1), FZD6(2), FZD7(2), FZD8(3), GSK3B(2), JUN(1), LDLR(10), MAPK10(6), MAPK9(1), MYC(2), PAFAH1B1(2), PLAU(2), PPP2R5C(2), PPP2R5E(2), PRKCA(8), PRKCD(2), PRKCE(4), PRKCG(10), PRKCH(5), PRKCI(5), PRKCQ(12), PRKCZ(1), PRKD1(2), RAC1(9), SFRP4(4), TCF7(1), WNT1(1), WNT10A(4), WNT10B(4), WNT11(2), WNT16(1), WNT2(6), WNT2B(2), WNT3(4), WNT4(2), WNT5A(5), WNT5B(2), WNT6(2), WNT7A(10), WNT7B(2) 11932958 196 76 188 106 129 20 4 21 22 0 0.284 1.000 1.000 207 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(10), BMPR1B(2), CCND2(4), CDK4(2), CDKN1B(1), DAZL(3), DMC1(4), EGR1(1), ESR2(5), FSHR(12), GJA4(3), INHA(3), LHCGR(14), MLH1(5), MSH5(5), NCOR1(14), NR5A1(6), NRIP1(5), PGR(10), PRLR(22), PTGER2(5), SMPD1(1), VDR(2), ZP2(9) 6990418 148 75 135 79 105 9 3 14 17 0 0.661 1.000 1.000 208 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(36), B3GALT4(1), CDR1(8), DGKI(14), IL6ST(6), MRPL19(1), PIGK(4), RPL10(2), RPL11(1), RPL13A(1), RPL14(1), RPL15(2), RPL18(3), RPL18A(1), RPL21(1), RPL22(1), RPL26(1), RPL27(2), RPL27A(1), RPL3(1), RPL30(1), RPL35(1), RPL38(1), RPL3L(3), RPL4(4), RPL5(3), RPL7(2), RPL7A(1), RPLP0(1), RPS10(1), RPS11(1), RPS13(1), RPS2(1), RPS20(2), RPS24(1), RPS27(1), RPS29(1), RPS5(1), RPS6(1), RPS6KA1(4), RPS6KA2(4), RPS6KA6(5), RPS6KB1(2), RPS6KB2(2), RPS7(1), RPSA(1), SLC36A2(6), TBC1D10C(3), TSPAN9(1), UBC(4) 10389189 149 75 147 99 95 15 7 17 15 0 0.906 1.000 1.000 209 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(3), BAX(1), BCL2(2), BCL2L11(3), BIRC2(4), BIRC3(6), BIRC5(1), BNIP3L(2), CASP1(3), CASP10(4), CASP2(1), CASP3(1), CASP4(1), CASP7(4), CASP8(2), CASP9(3), CHUK(1), CYCS(1), DFFA(1), DFFB(2), FAS(3), FASLG(10), GZMB(2), HELLS(3), IKBKB(2), IRF2(4), IRF3(3), IRF4(2), IRF5(2), IRF6(8), IRF7(5), JUN(1), LTA(2), MAP2K4(3), MAPK10(6), MDM2(2), MYC(2), NFKB1(3), NFKBIA(2), NFKBIB(1), PLEKHG5(8), PRF1(6), RELA(2), RIPK1(1), TNF(1), TNFRSF10B(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(7), TNFRSF25(4), TNFSF10(5), TP53(26), TP73(4), TRAF1(6), TRAF2(2), TRAF3(3) 11448323 191 74 188 100 126 17 13 15 20 0 0.376 1.000 1.000 210 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(11), AGMAT(3), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH4A1(5), ALDH9A1(2), AOC2(5), AOC3(6), ARG1(1), ARG2(1), ASL(3), CKM(2), CKMT1A(1), CKMT2(5), CPS1(13), DAO(8), GAMT(3), GATM(2), GLUD1(1), GOT1(4), GOT2(2), MAOA(2), MAOB(7), NOS1(38), NOS3(13), OAT(1), ODC1(2), OTC(2), P4HA1(6), P4HA2(4), P4HA3(10), P4HB(2), RARS(5), SMS(1) 8809036 195 74 190 116 140 20 11 8 16 0 0.336 1.000 1.000 211 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM2(1), CAMK1(4), CAMK1G(9), ELK1(1), FPR1(15), GNA15(2), HRAS(1), MAP2K1(7), MAP2K2(2), MAP2K3(4), MAP2K6(2), MAPK1(3), MAPK14(4), MAPK3(1), NCF2(5), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), NFKB1(3), NFKBIA(2), PAK1(2), PIK3C2G(32), PLCB1(33), PPP3CA(4), PPP3CB(1), PPP3CC(1), RAC1(9), RAF1(2), RELA(2), SYT1(12) 7618938 194 74 180 89 150 12 5 12 15 0 0.0824 1.000 1.000 212 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(3), ALAS2(2), BLVRA(1), BLVRB(1), COX10(4), COX15(2), CP(10), CPOX(2), EPRS(6), FECH(2), FTH1(2), FTMT(4), GUSB(3), HCCS(2), HMBS(1), HMOX1(1), MMAB(2), PPOX(2), UGT1A1(1), UGT1A10(13), UGT1A3(7), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(9), UGT1A8(3), UGT1A9(6), UGT2A1(12), UGT2A3(17), UGT2B10(20), UGT2B11(11), UGT2B15(18), UGT2B28(15), UGT2B4(23), UGT2B7(13), UROS(1) 8430852 230 74 223 89 160 20 10 13 27 0 0.00190 1.000 1.000 213 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(4), ADAM17(1), ATP6AP1(1), ATP6V0A1(5), ATP6V0A4(12), ATP6V0D2(7), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C2(6), ATP6V1E2(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), CASP3(1), CHUK(1), CSK(1), EGFR(16), F11R(4), GIT1(4), IGSF5(6), IKBKB(2), IL8(1), JAM2(9), JAM3(1), JUN(1), LYN(3), MAP2K4(3), MAP3K14(1), MAPK10(6), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(4), MAPK9(1), MET(12), NFKB1(3), NFKB2(3), NFKBIA(2), NOD1(3), PAK1(2), PLCG1(4), PLCG2(15), PTPN11(5), PTPRZ1(14), RAC1(9), RELA(2), SRC(1), TCIRG1(3), TJP1(9) 14121019 215 74 210 142 149 19 6 23 18 0 0.916 1.000 1.000 214 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(1), AKT2(6), AKT3(3), BCL2(2), BCR(6), BLNK(11), BTK(8), CD19(5), CD22(16), CD81(2), CR2(20), CSK(1), DAG1(3), FLOT1(1), GRB2(2), GSK3B(2), INPP5D(22), ITPR1(19), ITPR2(10), ITPR3(4), LYN(3), MAP4K1(6), MAPK1(3), MAPK3(1), NFATC1(13), NFATC2(6), NR0B2(6), PDK1(1), PIK3CA(2), PIK3CD(2), PIK3R1(2), PLCG2(15), PPP1R13B(5), PPP3CA(4), PPP3CB(1), PPP3CC(1), PTPRC(18), RAF1(2), SHC1(1), SOS1(6), SOS2(3), SYK(11), VAV1(13) 14785674 269 74 262 130 197 23 12 16 21 0 0.0228 1.000 1.000 215 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(6), ABP1(11), ACADL(2), ACADM(5), ACADSB(3), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), AOC2(5), AOC3(6), CNDP1(7), DPYD(38), DPYS(15), EHHADH(5), GAD1(7), GAD2(4), HADHA(7), MLYCD(2), SMS(1), UPB1(5) 5831648 155 73 148 75 110 11 9 15 10 0 0.105 1.000 1.000 216 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(4), F11(9), F12(1), F13B(16), F2(6), F5(20), F7(2), F8(29), F9(6), FGA(20), FGB(7), FGG(4), LPA(28), PLAT(2), PLAU(2), PLG(20), SERPINB2(8), SERPINE1(2), SERPINF2(3), VWF(32) 7026025 221 73 214 98 160 16 14 11 19 1 0.113 1.000 1.000 217 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(4), BMP4(2), BMP5(12), BMP6(8), BMP7(2), BTRC(4), CSNK1A1(2), CSNK1A1L(3), CSNK1D(1), CSNK1E(3), CSNK1G1(1), CSNK1G2(2), FBXW11(4), GLI1(9), GLI2(23), GLI3(8), GSK3B(2), HHIP(13), IHH(2), LRP2(59), PRKACA(2), PRKACB(2), PRKACG(7), PRKX(1), PTCH1(4), PTCH2(12), SHH(2), SMO(6), STK36(12), SUFU(2), WNT1(1), WNT10A(4), WNT10B(4), WNT11(2), WNT16(1), WNT2(6), WNT2B(2), WNT3(4), WNT3A(5), WNT4(2), WNT5A(5), WNT5B(2), WNT6(2), WNT7A(10), WNT7B(2), WNT8A(4), WNT8B(5), WNT9A(1), WNT9B(3), ZIC2(1) 12056305 280 73 268 152 201 27 9 21 22 0 0.211 1.000 1.000 218 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(5), AKT1(1), APC(12), CAMP(1), DAG1(3), DLG4(4), EPHB2(17), GNAI1(1), GNAQ(1), ITPR1(19), ITPR2(10), ITPR3(4), KCNJ3(14), KCNJ5(6), KCNJ9(4), MAPK1(3), PITX2(1), RAC1(9), RHO(2), RYR1(61) 9111261 178 73 172 120 134 17 6 10 11 0 0.555 1.000 1.000 219 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(33), COL4A2(20), COL4A3(24), COL4A4(58), COL4A5(41), COL4A6(28), P4HB(2), SLC23A1(3), SLC23A2(1), SLC2A1(3), SLC2A3(4) 4986954 217 73 210 62 184 9 7 8 9 0 0.241 1.000 1.000 220 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(12), CANT1(8), CDA(2), CTPS(2), CTPS2(2), DCTD(1), DHODH(1), DPYD(38), DPYS(15), ENTPD1(5), NT5E(4), NT5M(1), POLD1(3), POLD2(2), POLE(10), POLG(4), POLL(7), POLQ(15), POLR1B(5), POLR2A(10), POLR2B(11), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(1), RRM1(3), TK2(1), TXNRD1(3), TYMS(1), UCK1(2), UMPS(1), UNG(2), UPB1(5) 11500534 184 72 175 78 118 14 10 23 19 0 0.0207 1.000 1.000 221 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(4), ACTG2(1), ACTR2(2), AKT1(1), ANGPTL2(2), CFL1(1), FLNA(8), FLNC(37), FSCN1(4), FSCN2(1), FSCN3(9), GDI2(1), LIMK1(4), MYH2(53), MYLK(22), MYLK2(6), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PAK7(33), RHO(2), ROCK1(3), ROCK2(4), VASP(1), WASF1(1), WASL(3) 9550532 218 72 208 125 159 29 6 13 11 0 0.170 1.000 1.000 222 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(1), AKT1(1), AKT2(6), AKT3(3), BTK(8), CDKN2A(23), DAPP1(4), GRB2(2), GSK3B(2), IARS(5), IGFBP1(2), INPP5D(22), PDK1(1), PIK3CA(2), PPP1R13B(5), PTEN(12), RPS6KA1(4), RPS6KA2(4), RPS6KB1(2), SFN(1), SHC1(1), SOS1(6), SOS2(3), TEC(7), YWHAG(1), YWHAQ(2) 7219897 130 72 118 41 67 9 10 11 33 0 0.0208 1.000 1.000 223 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), GUSB(3), UGP2(1), UGT1A1(1), UGT1A10(13), UGT1A3(7), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(9), UGT1A8(3), UGT1A9(6), UGT2A1(12), UGT2A3(17), UGT2B10(20), UGT2B11(11), UGT2B15(18), UGT2B28(15), UGT2B4(23), UGT2B7(13), XYLB(2) 5439826 187 71 180 75 133 14 9 11 20 0 0.0103 1.000 1.000 224 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(6), ABP1(11), ACADM(5), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2), AOC2(5), AOC3(6), CNDP1(7), DPYD(38), DPYS(15), EHHADH(5), GAD1(7), GAD2(4), HADHA(7), HIBCH(1), MLYCD(2), SMS(1), UPB1(5) 5424702 142 71 135 72 101 9 9 14 9 0 0.166 1.000 1.000 225 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(5), ALOX15(4), ALOX5(8), CYP1A2(8), CYP2C18(18), CYP2C19(29), CYP2C8(21), CYP2C9(28), CYP2E1(8), CYP2J2(4), CYP3A4(13), CYP3A43(10), CYP3A5(4), CYP3A7(14), HSD3B7(1), PLA2G12B(3), PLA2G2A(2), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(14), PLA2G4A(8), PLA2G6(7), RDH12(1), RDH13(3) 4777442 222 71 214 130 179 9 6 11 17 0 0.115 1.000 1.000 226 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(3), ABO(4), B3GALNT1(5), B3GALT1(10), B3GALT2(1), B3GALT4(1), B3GALT5(1), B3GNT1(2), B3GNT2(2), B3GNT3(4), B3GNT4(2), B3GNT5(1), B4GALNT1(1), B4GALT1(1), B4GALT2(2), B4GALT3(2), B4GALT6(1), FUT1(3), FUT2(2), FUT3(4), FUT4(1), FUT5(6), FUT6(1), FUT7(2), FUT9(14), GBGT1(1), PIGB(3), PIGC(1), PIGF(2), PIGG(9), PIGK(4), PIGL(2), PIGN(2), PIGO(9), PIGQ(6), PIGS(1), PIGT(1), PIGU(4), PIGV(7), PIGX(1), PIGZ(1), ST3GAL1(5), ST3GAL4(1), ST3GAL5(2), ST3GAL6(2), ST6GALNAC3(4), ST6GALNAC5(5), ST6GALNAC6(2), ST8SIA5(5), UGCG(1) 9693273 157 70 155 88 97 16 11 17 16 0 0.292 1.000 1.000 227 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(29), C5(9), C6(39), C7(25), ICAM1(2), IL1A(3), IL8(1), ITGA4(26), ITGAL(17), ITGB1(4), ITGB2(10), SELP(15), SELPLG(4), TNF(1), VCAM1(13) 4923296 198 70 185 89 153 6 6 15 17 1 0.0250 1.000 1.000 228 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(1), AKT2(6), AKT3(3), BCR(6), BLNK(11), BTK(8), CD19(5), CSK(1), DAG1(3), EPHB2(17), GRB2(2), ITPKB(5), LYN(3), MAP2K1(7), MAP2K2(2), MAPK1(3), NFAT5(3), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PI3(6), PIK3CA(2), PIK3CD(2), PIK3R1(2), PLCG2(15), PPP1R13B(5), RAF1(2), SERPINA4(10), SHC1(1), SOS1(6), SOS2(3), SYK(11), VAV1(13) 10588268 176 70 171 102 123 15 10 15 13 0 0.576 1.000 1.000 229 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(3), C1QB(2), C1R(9), C1S(15), C2(9), C3(29), C5(9), C6(39), C7(25), C8A(27), C8B(30), C9(14), MASP1(6) 4118678 217 69 199 90 176 12 4 13 11 1 0.00508 1.000 1.000 230 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(3), ATM(10), ATR(13), CCNA1(12), CCND1(1), CCNE1(3), CDC25A(6), CDK4(2), CDK6(1), CDKN1A(2), CDKN1B(1), CDKN2A(23), E2F1(5), GSK3B(2), HDAC1(1), RB1(3), TFDP1(1), TGFB2(1), TGFB3(1), TP53(26) 6060926 117 69 103 36 60 3 8 11 33 2 0.0147 1.000 1.000 231 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(38), GABBR1(4), GPRC5A(2), GPRC5B(3), GPRC5C(7), GPRC5D(2), GRM1(9), GRM2(3), GRM3(39), GRM4(15), GRM5(9), GRM7(21), GRM8(28) 4183956 180 69 170 136 138 14 5 11 12 0 0.445 1.000 1.000 232 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(3), AANAT(1), ABP1(11), ACAT2(1), ACMSD(7), AFMID(1), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2), AOC2(5), AOC3(6), AOX1(15), ASMT(4), CARM1(4), CAT(4), CYP1A1(8), CYP1A2(8), CYP1B1(1), DDC(7), EHHADH(5), GCDH(3), HAAO(3), HADHA(7), HEMK1(1), HSD17B10(1), HSD17B4(3), INMT(5), KMO(5), KYNU(6), LCMT1(4), LNX1(12), MAOA(2), MAOB(7), METTL2B(6), NFX1(4), OGDH(8), OGDHL(22), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(7), TDO2(2), TPH1(2), TPH2(9), WARS(3), WARS2(1), WBSCR22(1) 12122081 245 69 239 132 181 19 12 21 12 0 0.206 1.000 1.000 233 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(3), CRK(2), DOCK1(13), ELK1(1), FOS(1), GAB1(3), GRB2(2), HGF(13), HRAS(1), ITGA1(15), ITGB1(4), JUN(1), MAP2K1(7), MAP2K2(2), MAP4K1(6), MAPK1(3), MAPK3(1), MET(12), PAK1(2), PIK3CA(2), PIK3R1(2), PTEN(12), PTK2(3), PTK2B(7), PTPN11(5), PXN(3), RAF1(2), RAP1A(1), RASA1(1), SOS1(6), SRC(1), STAT3(6) 8729941 143 69 138 69 87 9 6 24 17 0 0.667 1.000 1.000 234 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(6), CD3D(5), CSK(1), CTLA4(1), DAG1(3), EPHB2(17), FBXW7(9), GRAP2(1), GRB2(2), ITK(19), ITPKB(5), LCK(9), LCP2(5), MAPK1(3), NFAT5(3), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PAK7(33), PLCG1(4), PTPRC(18), RAF1(2), RASGRP1(7), RASGRP2(3), RASGRP3(8), RASGRP4(9), SOS1(6), SOS2(3), VAV1(13), ZAP70(4) 11082613 226 69 218 119 160 16 9 22 19 0 0.393 1.000 1.000 235 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(4), AKR1D1(14), ARSD(2), ARSE(4), CYP11B1(8), CYP11B2(9), HSD11B1(8), HSD17B2(7), HSD17B3(5), HSD3B1(4), HSD3B2(9), SRD5A1(2), SRD5A2(5), STS(3), SULT1E1(10), SULT2A1(4), UGT1A1(1), UGT1A10(13), UGT1A3(7), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(9), UGT1A8(3), UGT1A9(6), UGT2B15(18), UGT2B4(23) 5451237 189 68 179 87 127 19 8 11 24 0 0.0126 1.000 1.000 236 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(3), ACAA2(1), ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), AKR1C4(4), AKR1D1(14), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), BAAT(6), CEL(6), CYP27A1(2), CYP7A1(5), HADHB(2), SOAT2(4), SRD5A1(2), SRD5A2(5) 4679070 158 68 148 59 106 16 8 14 14 0 0.00104 1.000 1.000 237 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(1), B4GALT2(2), FBP2(1), G6PC(4), GAA(5), GALK1(1), GALK2(1), GALT(2), GANAB(5), GCK(10), GLA(1), GLB1(5), HK1(1), HK2(5), HK3(10), LALBA(5), LCT(31), MGAM(89), PGM1(2), PGM3(1) 6507015 184 68 176 101 139 19 4 15 7 0 0.105 1.000 1.000 238 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(3), ACAA2(1), ACAD8(1), ACAD9(1), ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), AKR1B10(5), AKR1C4(4), AKR1D1(14), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2), BAAT(6), CEL(6), CYP27A1(2), CYP7A1(5), HADHB(2), HSD3B7(1), LIPA(1), RDH12(1), RDH13(3), SLC27A5(4), SOAT1(3), SOAT2(4), SRD5A1(2), SRD5A2(5) 6370495 169 68 159 76 115 16 11 13 14 0 0.0129 1.000 1.000 239 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(22), ATP4A(10), ATP4B(1), ATP5A1(1), ATP5B(1), ATP5C1(1), ATP5F1(6), ATP5H(1), ATP5O(3), ATP6AP1(1), ATP6V0A1(5), ATP6V0A4(12), ATP6V0D2(7), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C2(6), ATP6V1E2(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), COX10(4), COX15(2), COX4I2(1), COX5B(1), COX6B1(1), COX7B(1), COX7B2(1), COX8A(1), CYC1(3), LHPP(1), NDUFA10(1), NDUFA12(1), NDUFA13(5), NDUFA9(2), NDUFAB1(1), NDUFB2(1), NDUFB5(1), NDUFB6(2), NDUFC2(1), NDUFS2(1), NDUFS3(1), NDUFS4(2), NDUFS5(1), NDUFS6(1), NDUFS7(3), NDUFS8(3), NDUFV1(1), PPA1(1), PPA2(2), SDHA(1), SDHC(2), TCIRG1(3), UQCRC1(3), UQCRFS1(2) 11245773 156 68 151 87 100 16 9 18 13 0 0.483 1.000 1.000 240 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(5), AGPAT2(3), AGPAT3(3), AGPAT4(5), AGPAT6(2), CDS1(6), CDS2(4), CHAT(11), CHKA(2), CHKB(2), CHPT1(1), DGKA(1), DGKB(16), DGKD(5), DGKE(5), DGKG(10), DGKH(6), DGKI(14), DGKQ(3), DGKZ(6), GNPAT(2), GPAM(5), GPD1(7), GPD1L(2), GPD2(1), LYPLA1(1), LYPLA2(1), MYST3(10), MYST4(11), NAT6(2), PCYT1A(2), PCYT1B(3), PEMT(1), PISD(2), PLA2G12B(3), PLA2G2A(2), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(14), PLA2G4A(8), PLA2G6(7), PLD1(7), PLD2(3), PNPLA3(1), PPAP2B(4), PPAP2C(6), SH3GLB1(2) 13083949 226 68 217 117 155 21 7 20 23 0 0.258 1.000 1.000 241 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(3), C1QB(2), C1R(9), C1S(15), C2(9), C3(29), C5(9), C6(39), C7(25), C8A(27), C9(14), MASP1(6), MASP2(7), MBL2(8) 4222656 202 67 186 85 163 10 2 13 13 1 0.00973 1.000 1.000 242 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(5), B4GALT1(1), B4GALT2(2), G6PC(4), G6PC2(2), GAA(5), GALK1(1), GALK2(1), GALT(2), GANC(2), GCK(10), GLA(1), GLB1(5), HK1(1), HK2(5), HK3(10), HSD3B7(1), LALBA(5), LCT(31), MGAM(89), PFKL(2), PGM1(2), PGM3(1), RDH12(1), RDH13(3), UGP2(1) 7715250 195 67 187 112 150 18 3 15 9 0 0.143 1.000 1.000 243 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(1), DLG4(4), GRIN1(6), GRIN2A(57), GRIN2B(32), GRIN2C(7), GRIN2D(4), NOS1(38), PPP3CA(4), PPP3CB(1), PPP3CC(1), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(8), SYT1(12) 5092308 192 66 187 124 149 15 3 12 13 0 0.411 1.000 1.000 244 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(6), ALOX12(4), ALOX15(4), ALOX5(8), CYP4F2(7), CYP4F3(17), EPX(5), GGT1(4), LPO(11), LTA4H(2), MPO(6), PLA2G2A(2), PLA2G2E(2), PLA2G3(14), PLA2G4A(8), PLA2G6(7), PRDX1(1), PRDX2(2), PRDX6(2), PTGDS(2), PTGIS(9), PTGS1(14), PTGS2(6), TBXAS1(8), TPO(30) 5589717 181 66 177 108 139 14 3 14 11 0 0.135 1.000 1.000 245 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B4GALT5(2), C1GALT1(5), C1GALT1C1(1), GALNT1(2), GALNT10(4), GALNT11(1), GALNT12(5), GALNT13(12), GALNT14(16), GALNT2(4), GALNT3(2), GALNT4(2), GALNT5(9), GALNT6(13), GALNT7(5), GALNT8(14), GALNT9(3), GALNTL1(2), GALNTL2(13), GALNTL4(1), GALNTL5(13), GCNT1(4), GCNT3(3), OGT(5), ST3GAL1(5), ST6GALNAC1(3), WBSCR17(24) 6475375 173 65 168 79 127 10 2 14 20 0 0.0937 1.000 1.000 246 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(3), APOA1(2), CD36(3), CPT1B(6), CREBBP(14), EHHADH(5), EP300(8), FABP1(3), HSD17B4(3), JUN(1), LPL(2), MAPK1(3), MAPK3(1), ME1(14), MYC(2), NCOA1(8), NCOR1(14), NCOR2(15), NFKBIA(2), NR0B2(6), NR1H3(2), NR2F1(7), NRIP1(5), PDGFA(1), PIK3CA(2), PIK3R1(2), PPARA(4), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(8), PTGS2(6), RB1(3), RELA(2), RXRA(1), SP1(4), STAT5A(2), STAT5B(4), TNF(1) 12719184 186 65 182 91 128 16 13 14 13 2 0.315 1.000 1.000 247 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(3), C1QB(2), C1R(9), C1S(15), C2(9), C3(29), C5(9), C6(39), C7(25), C8A(27), C9(14) 3458389 181 64 165 74 145 9 2 13 11 1 0.0112 1.000 1.000 248 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(5), AGPAT2(3), AGPAT3(3), AGPAT4(5), AGPS(3), CDS1(6), CDS2(4), CHAT(11), CHKA(2), CHKB(2), CLC(2), CPT1B(6), DGKA(1), DGKB(16), DGKD(5), DGKE(5), DGKG(10), DGKH(6), DGKQ(3), DGKZ(6), GNPAT(2), GPD1(7), GPD2(1), LGALS13(2), LYPLA1(1), LYPLA2(1), PAFAH1B1(2), PAFAH2(2), PCYT1A(2), PCYT1B(3), PEMT(1), PISD(2), PLA2G2A(2), PLA2G2E(2), PLA2G3(14), PLA2G4A(8), PLA2G6(7), PLCB2(7), PLCG1(4), PLCG2(15), PPAP2B(4), PPAP2C(6) 9999785 199 64 194 99 149 13 4 17 16 0 0.0341 1.000 1.000 249 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(4), APAF1(3), ARHGDIB(2), BAG4(1), BCL2(2), BIRC2(4), BIRC3(6), CASP2(1), CASP3(1), CASP7(4), CASP8(2), CASP9(3), CFLAR(3), CHUK(1), CRADD(1), CYCS(1), DAXX(5), DFFA(1), DFFB(2), GSN(5), LMNA(3), LMNB1(1), LMNB2(4), MAP2K7(2), MAP3K14(1), MAP3K5(11), MDM2(2), NFKB1(3), NFKBIA(2), NUMA1(5), PAK2(2), PRKCD(2), PRKDC(13), PSEN1(1), PSEN2(2), PTK2(3), RASA1(1), RB1(3), RELA(2), RIPK1(1), SPTAN1(4), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF1(6), TRAF2(2) 13877634 132 64 131 69 73 14 11 18 14 2 0.531 1.000 1.000 250 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(3), ALPL(6), ALPP(6), ALPPL2(7), ASCC3(5), ATP13A2(7), DDX18(4), DDX19A(1), DDX23(5), DDX4(8), DDX41(4), DDX47(1), DDX50(2), DDX51(3), DDX52(3), DDX54(2), DDX55(2), DDX56(2), DHX58(4), ENTPD7(1), EP400(16), ERCC2(1), ERCC3(3), FPGS(3), GGH(2), IFIH1(8), MOV10L1(17), NUDT5(1), NUDT8(1), QDPR(1), RAD54B(5), RUVBL2(2), SETX(13), SKIV2L2(3), SMARCA2(9), SMARCA5(3), SPR(1) 12499328 165 64 158 84 106 11 5 22 21 0 0.414 1.000 1.000 251 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(5), BCR(6), BLNK(11), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(1), LYN(3), MAP2K1(7), MAPK1(3), MAPK3(1), MAPK8IP3(6), PAPPA(39), RAC1(9), RPS6KA1(4), SHC1(1), SOS1(6), SYK(11), VAV1(13), VAV2(3), VAV3(6) 6367392 140 64 131 72 106 9 3 14 8 0 0.288 1.000 1.000 252 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(8), CALM2(1), ELK1(1), FCER1A(8), FCER1G(1), FOS(1), GRB2(2), HRAS(1), JUN(1), LYN(3), MAP2K1(7), MAP2K4(3), MAP2K7(2), MAPK1(3), MAPK3(1), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), PAK2(2), PIK3CA(2), PIK3R1(2), PLA2G4A(8), PLCG1(4), PPP3CA(4), PPP3CB(1), PPP3CC(1), RAF1(2), SHC1(1), SOS1(6), SYK(11), SYT1(12), VAV1(13) 8592191 142 63 137 72 106 9 8 11 8 0 0.499 1.000 1.000 253 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(4), AARS2(2), CARS(6), CARS2(1), DARS(2), DARS2(1), EPRS(6), FARS2(3), FARSA(5), FARSB(5), GARS(5), HARS(3), HARS2(2), IARS(5), IARS2(10), KARS(3), LARS(8), LARS2(3), MARS(5), MARS2(3), MTFMT(1), NARS(2), NARS2(4), QARS(6), RARS(5), RARS2(1), SARS(4), SARS2(2), TARS(1), TARS2(7), VARS(14), VARS2(4), WARS(3), WARS2(1), YARS(1), YARS2(1) 11002468 139 63 132 60 84 17 7 14 17 0 0.104 1.000 1.000 254 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(1), AKT2(6), AKT3(3), ANKRD6(3), APC(12), AXIN1(6), AXIN2(2), CER1(7), CSNK1A1(2), CTNNB1(6), DACT1(5), DKK1(1), DKK2(9), DKK3(3), DKK4(1), FSTL1(2), GSK3B(2), LRP1(22), MVP(4), NKD1(5), NKD2(4), PIN1(1), PSEN1(1), PTPRA(3), SENP2(9), TSHB(3), WIF1(5) 7998556 128 63 127 70 74 18 5 15 16 0 0.650 1.000 1.000 255 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(3), AGTR2(3), CALM2(1), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CDK5(3), F2(6), FYN(5), GNA11(6), GNAI1(1), GRB2(2), HRAS(1), JAK2(6), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK14(4), MAPK3(1), MAPT(7), MYLK(22), PLCG1(4), PRKCA(8), PTK2B(7), RAF1(2), SHC1(1), SOS1(6), STAT1(2), STAT3(6), STAT5A(2), SYT1(12) 8303608 145 62 141 97 98 12 7 16 12 0 0.886 1.000 1.000 256 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), AKT2(6), AKT3(3), ARHGEF11(10), BCL2(2), DLG4(4), GNA13(1), LPA(28), MAP2K4(3), MAP3K5(11), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PDK1(1), PHKA2(6), PI3(6), PIK3CB(10), PLD1(7), PLD2(3), PLD3(1), PTK2(3), ROCK1(3), ROCK2(4), SERPINA4(10), SRF(1), TBXA2R(3) 9819347 139 62 135 76 83 12 6 23 15 0 0.722 1.000 1.000 257 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(8), ALDOC(1), DLAT(2), DLD(1), ENO1(2), ENO3(2), FBP1(1), FBP2(1), G6PC(4), GCK(10), GOT1(4), GOT2(2), GPI(2), HK1(1), HK2(5), HK3(10), LDHA(2), LDHAL6B(6), LDHC(3), MDH1(1), MDH2(2), PC(6), PCK1(20), PDHA1(1), PDHA2(9), PDHB(1), PDHX(2), PFKL(2), PGK1(2), PGK2(17), PKLR(6), PKM2(5) 8534309 142 61 136 74 111 7 8 6 10 0 0.0222 1.000 1.000 258 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(4), AARS2(2), ABAT(6), ACY3(1), ADSL(6), ADSS(1), ADSSL1(4), AGXT(8), AGXT2(13), ASL(3), ASNS(7), ASPA(3), ASRGL1(1), ASS1(3), CAD(12), CRAT(4), DARS(2), DARS2(1), DDO(4), DLAT(2), DLD(1), GAD1(7), GAD2(4), GOT1(4), GOT2(2), GPT(3), NARS(2), NARS2(4), PC(6), PDHA1(1), PDHA2(9), PDHB(1) 7614721 131 61 128 71 92 12 8 14 5 0 0.292 1.000 1.000 259 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(3), AASDHPPT(1), AASS(1), ACAT2(1), AKR1B10(5), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2), BBOX1(3), DOT1L(5), EHHADH(5), EHMT1(6), EHMT2(4), GCDH(3), HADHA(7), HSD17B10(1), HSD17B4(3), HSD3B7(1), NSD1(10), OGDH(8), OGDHL(22), PIPOX(3), PLOD1(1), PLOD2(5), PLOD3(1), RDH12(1), RDH13(3), SETD1A(17), SETD7(1), SETDB1(1), SHMT2(2), SUV39H1(1), TMLHE(1) 11586538 143 61 141 71 98 13 7 15 10 0 0.218 1.000 1.000 260 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(16), ACACB(14), ACAT2(1), ACOT12(8), ACSS2(3), AKR1B1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2), DLAT(2), DLD(1), GLO1(1), HAGH(1), LDHA(2), LDHAL6A(1), LDHAL6B(6), LDHC(3), LDHD(1), MDH1(1), MDH2(2), ME1(14), ME2(1), ME3(6), PC(6), PCK1(20), PCK2(3), PDHA1(1), PDHA2(9), PDHB(1), PKLR(6), PKM2(5) 9403502 154 61 151 72 107 10 8 14 15 0 0.0436 1.000 1.000 261 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(2), CHUK(1), DAXX(5), EGF(14), EGFR(16), ETS1(3), ETS2(8), FOS(1), HOXA7(2), HRAS(1), IKBKB(2), JUN(1), MAP2K1(7), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP2K7(2), MAP3K14(1), MAP3K5(11), MAPK1(3), MAPK13(4), MAPK14(4), MAPK3(1), NFKB1(3), NFKBIA(2), PPP2CA(1), PRKCA(8), PRKCD(2), PRKCE(4), PRKCG(10), PRKCH(5), PRKCQ(12), RAF1(2), RELA(2), RIPK1(1), SP1(4), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(2) 9805853 160 61 156 105 113 12 5 16 14 0 0.903 1.000 1.000 262 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(6), F2R(4), GNAI1(1), HRAS(1), ITGA1(15), ITGB1(4), MAP2K1(7), MAPK1(3), MAPK3(1), PLA2G4A(8), PLCB1(33), PRKCA(8), PTGS1(14), PTK2(3), RAF1(2), SRC(1), SYK(11), TBXAS1(8) 4878974 130 61 121 61 98 8 3 14 7 0 0.157 1.000 1.000 263 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(29), C5(9), C6(39), C7(25), C8A(27), C9(14) 2481891 143 60 129 56 117 6 2 8 9 1 0.0195 1.000 1.000 264 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(10), ATR(13), BRCA1(6), BRCA2(12), CHEK1(1), FANCA(2), FANCC(3), FANCD2(11), FANCE(2), FANCF(1), FANCG(3), HUS1(1), MRE11A(3), RAD1(2), RAD17(4), RAD50(3), RAD9A(4), TP53(26) 8862282 107 60 102 42 70 1 6 12 18 0 0.349 1.000 1.000 265 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(8), CFL1(1), GNAQ(1), GNAS(12), HRAS(1), LIMK1(4), MAP2K1(7), MAPK1(3), MAPK3(1), MYL2(4), NOX1(7), PIK3C2G(32), PLCB1(33), PPP1R12B(5), PRKCA(8), PTK2(3), RAF1(2), ROCK2(4) 5018971 137 60 126 55 105 3 2 19 8 0 0.0656 1.000 1.000 266 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(11), AGXT(8), AGXT2(13), AKR1B10(5), ALAS2(2), AMT(1), AOC2(5), AOC3(6), BHMT(6), CBS(5), CHDH(7), CHKA(2), CHKB(2), DAO(8), DLD(1), DMGDH(9), GAMT(3), GARS(5), GATM(2), GCAT(3), GLDC(2), GNMT(1), HSD3B7(1), MAOA(2), MAOB(7), PEMT(1), PHGDH(10), PIPOX(3), PISD(2), PSAT1(1), RDH12(1), RDH13(3), SARDH(9), SARS(4), SARS2(2), SHMT2(2), TARS(1), TARS2(7) 8566724 163 60 155 90 120 9 6 12 16 0 0.170 1.000 1.000 267 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(5), ARG1(1), ARG2(1), ASL(3), ASS1(3), CKM(2), CKMT1A(1), CKMT2(5), CPS1(13), DAO(8), EPRS(6), GAMT(3), GATM(2), GLUD1(1), GLUD2(1), GOT1(4), GOT2(2), NOS1(38), NOS3(13), OAT(1), OTC(2), P4HA1(6), P4HA2(4), P4HA3(10), PRODH(1), PYCR2(1), RARS(5), RARS2(1) 7169380 143 60 138 92 103 13 6 8 13 0 0.695 1.000 1.000 268 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(2), ADRBK2(3), ARRB2(3), CALM2(1), CALML3(3), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CLCA1(4), CLCA2(7), CLCA4(19), CNGA3(17), CNGA4(8), CNGB1(13), GNAL(2), GUCA1A(3), GUCA1B(1), GUCA1C(3), PDC(3), PDE1C(25), PRKACA(2), PRKACB(2), PRKACG(7), PRKG1(7), PRKG2(10), PRKX(1) 6032005 158 60 150 105 113 13 6 17 9 0 0.774 1.000 1.000 269 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(2), AKT1(1), ANGPTL2(2), DAG1(3), DGKA(1), ETFA(1), GCA(3), ITGA9(9), ITPKB(5), ITPR1(19), ITPR2(10), ITPR3(4), MAP2K1(7), MAPK1(3), MAPK3(1), NR1I3(7), PAK1(2), PDE3A(14), PDE3B(5), PI3(6), PIK3C2G(32), PIK3CA(2), PIK3CD(2), PIK3R1(2), RIPK3(8), VASP(1) 9712036 152 60 145 60 116 11 6 8 11 0 0.00210 1.000 1.000 270 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM2(1), CD3D(5), CD3E(2), ELK1(1), FOS(1), FYN(5), GRB2(2), HRAS(1), JUN(1), LCK(9), MAP2K1(7), MAP2K4(3), MAPK3(1), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), NFKB1(3), NFKBIA(2), PIK3CA(2), PIK3R1(2), PLCG1(4), PPP3CA(4), PPP3CB(1), PPP3CC(1), PRKCA(8), PTPN7(1), RAC1(9), RAF1(2), RASA1(1), RELA(2), SHC1(1), SOS1(6), SYT1(12), VAV1(13), ZAP70(4) 9547551 147 60 139 72 106 15 4 13 9 0 0.406 1.000 1.000 271 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(3), BAX(1), BCL2(2), BIRC2(4), BIRC3(6), CASP2(1), CASP3(1), CASP7(4), CASP8(2), CASP9(3), CYCS(1), FAS(3), FASLG(10), GZMB(2), JUN(1), MAP2K4(3), MAP3K14(1), MAPK10(6), MCL1(2), MDM2(2), MYC(2), NFKB1(3), NFKBIA(2), PARP1(7), PRF1(6), RELA(2), RIPK1(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TNFSF10(5), TP53(26), TRAF1(6), TRAF2(2) 7465931 124 59 121 52 75 11 11 10 17 0 0.0918 1.000 1.000 272 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(2), ARSE(4), B4GALT6(1), DEGS1(1), DEGS2(3), ENPP7(3), GAL3ST1(7), GALC(1), GBA(2), GLA(1), GLB1(5), LCT(31), NEU1(4), NEU2(12), NEU3(2), NEU4(7), PPAP2B(4), PPAP2C(6), SGMS1(12), SGPP2(5), SMPD1(1), SMPD3(7), SMPD4(4), SPHK1(1), SPHK2(5), SPTLC2(5), UGCG(1), UGT8(5) 7089757 142 59 138 96 109 10 4 13 6 0 0.804 1.000 1.000 273 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(4), ACTG2(1), ADCY3(2), ADCY9(9), AK1(1), ARF4(1), ARF5(1), ARL4D(2), ATP6V0A1(5), ATP6V0A4(12), ATP6V0D2(7), ATP6V1A(2), ATP6V1C2(6), ATP6V1E2(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), ERO1L(4), GNAS(12), PDIA4(3), PLCG1(4), PLCG2(15), PRKCA(8), SEC61A1(2), SEC61A2(4) 7447484 120 59 117 90 85 5 4 14 12 0 0.923 1.000 1.000 274 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(5), ADRA1B(2), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(1), CHRM1(4), CHRM2(10), CHRM3(11), CHRM4(5), CHRM5(2), DRD1(8), DRD2(9), DRD3(1), DRD4(1), DRD5(18), HRH1(11), HRH2(3), HTR1A(7), HTR1D(3), HTR1E(3), HTR1F(5), HTR2A(7), HTR2C(6), HTR4(5), HTR5A(11), HTR6(1), HTR7(7) 5035778 160 59 154 130 107 20 5 14 14 0 0.230 1.000 1.000 275 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(19), AR(7), ESR1(2), ESR2(5), ESRRA(1), HNF4A(15), NPM1(1), NR0B1(2), NR1D2(5), NR1H2(2), NR1H3(2), NR1I2(3), NR1I3(7), NR2C2(2), NR2E1(3), NR2F1(7), NR3C1(2), NR4A1(2), NR4A2(1), NR5A1(6), NR5A2(11), PGR(10), PPARA(4), PPARD(2), PPARG(8), RARA(1), RARB(3), RARG(1), ROR1(9), RORA(3), RORC(5), RXRA(1), RXRB(1), RXRG(3), THRA(1), THRB(12), VDR(2) 8342463 171 59 162 92 130 13 2 13 13 0 0.177 1.000 1.000 276 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(3), ACAA2(1), ACADL(2), ACADM(5), ACADS(2), ACADSB(3), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH6A1(2), ALDH9A1(2), AOX1(15), BCAT1(9), BCKDHA(1), BCKDHB(1), EHHADH(5), HADHA(7), HADHB(2), HIBADH(7), HMGCL(2), IVD(3), MCCC1(5), MCEE(1), MUT(4), OXCT1(3), PCCA(2), PCCB(1) 7254789 113 59 110 54 77 10 3 12 11 0 0.332 1.000 1.000 277 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(10), ATR(13), BRCA1(6), CDC25A(6), CDC25B(3), CDC25C(3), CDC34(3), CDKN1A(2), CHEK1(1), EP300(8), MDM2(2), MYT1(15), PRKDC(13), RPS6KA1(4), TP53(26), WEE1(2), YWHAQ(2) 8446431 119 58 115 46 74 10 7 12 16 0 0.213 1.000 1.000 278 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(11), AGXT(8), AGXT2(13), ALAS2(2), AMT(1), AOC2(5), AOC3(6), BHMT(6), CBS(5), CHDH(7), CHKA(2), CHKB(2), CPT1B(6), DAO(8), DLD(1), DMGDH(9), GAMT(3), GARS(5), GATM(2), GCAT(3), GLDC(2), MAOA(2), MAOB(7), PEMT(1), PISD(2), PLCB2(7), PLCG1(4), PLCG2(15), SARDH(9), SARS(4), SHMT2(2), TARS(1) 8429978 161 58 156 93 124 9 6 8 14 0 0.182 1.000 1.000 279 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(6), ACAA1(3), ACAA2(1), ACADM(5), ACADS(2), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH6A1(2), ALDH7A1(3), ALDH9A1(2), AOX1(15), AUH(3), BCAT1(9), BCAT2(1), BCKDHA(1), BCKDHB(1), DBT(1), DLD(1), EHHADH(5), HADHA(7), HADHB(2), HIBADH(7), HIBCH(1), HMGCL(2), HMGCS1(1), HMGCS2(14), HSD17B10(1), HSD17B4(3), IVD(3), MCCC1(5), MCEE(1), MUT(4), OXCT1(3), OXCT2(2), PCCA(2), PCCB(1) 8664368 133 58 129 60 89 12 6 16 10 0 0.218 1.000 1.000 280 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(16), ACAT2(1), AKR1B1(2), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), DLAT(2), DLD(1), GLO1(1), HAGH(1), LDHA(2), LDHC(3), LDHD(1), MDH1(1), MDH2(2), ME1(14), ME2(1), ME3(6), PC(6), PCK1(20), PDHA1(1), PDHA2(9), PDHB(1), PKLR(6), PKM2(5) 7432233 128 58 127 57 91 9 6 11 11 0 0.0516 1.000 1.000 281 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(11), BTK(8), CALM2(1), CD79A(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(1), LYN(3), MAP2K1(7), MAPK14(4), MAPK3(1), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), PLCG1(4), PPP3CA(4), PPP3CB(1), PPP3CC(1), PRKCA(8), RAC1(9), RAF1(2), SHC1(1), SOS1(6), SYK(11), SYT1(12), VAV1(13) 7656017 144 57 135 65 109 8 5 12 10 0 0.180 1.000 1.000 282 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(17), AKT1(1), GNAI1(1), ITGAV(5), ITGB3(9), MAPK1(3), MAPK3(1), PDGFA(1), PDGFRA(15), PIK3CA(2), PIK3R1(2), PLCB1(33), PRKCA(8), PTK2(3), RAC1(9), SMPD1(1), SPHK1(1), SRC(1) 5524375 113 57 105 51 88 4 4 11 6 0 0.0993 1.000 1.000 283 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(11), ACY3(1), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH3B1(2), ALDH3B2(5), ALDH7A1(3), ALDH9A1(2), AMDHD1(2), AOC2(5), AOC3(6), ASPA(3), CARM1(4), CNDP1(7), DDC(7), FTCD(1), HAL(8), HARS(3), HARS2(2), HDC(8), HEMK1(1), LCMT1(4), MAOA(2), MAOB(7), METTL2B(6), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(7), PRPS1(1), PRPS2(1), UROC1(8), WBSCR22(1) 7921237 143 57 142 103 100 16 9 10 8 0 0.857 1.000 1.000 284 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ACAD9(1), ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), DHRS1(2), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(3), MYST3(10), MYST4(11), NAT6(2), PNPLA3(1), SH3GLB1(2) 5036341 119 57 111 52 86 10 5 14 4 0 0.213 1.000 1.000 285 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(5), AADAC(10), ABAT(6), ACADS(2), ACAT2(1), ACSM1(12), AKR1B10(5), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH5A1(7), ALDH7A1(3), ALDH9A1(2), BDH1(4), DDHD1(5), EHHADH(5), GAD1(7), GAD2(4), HADHA(7), HMGCL(2), HMGCS1(1), HMGCS2(14), HSD17B10(1), HSD17B4(3), HSD3B7(1), ILVBL(2), L2HGDH(2), OXCT1(3), OXCT2(2), PDHA1(1), PDHA2(9), PDHB(1), PLA1A(4), PPME1(1), PRDX6(2), RDH12(1), RDH13(3) 8154067 150 57 148 80 106 12 8 11 13 0 0.262 1.000 1.000 286 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(3), BLVRA(1), BLVRB(1), CP(10), CPOX(2), EPRS(6), FECH(2), GUSB(3), HCCS(2), HMBS(1), HMOX1(1), PPOX(2), UGT1A1(1), UGT1A10(13), UGT1A3(7), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(9), UGT1A8(3), UGT1A9(6), UGT2B15(18), UGT2B4(23), UROS(1) 5548676 126 57 121 61 84 12 5 7 18 0 0.207 1.000 1.000 287 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(5), EIF2B1(6), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(1), EIF2S1(1), FLT1(21), FLT4(19), HIF1A(1), HRAS(1), KDR(25), NOS3(13), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(8), PTK2(3), PXN(3), SHC1(1), VHL(2) 6842995 123 57 113 63 85 10 1 13 14 0 0.349 1.000 1.000 288 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(3), AGTR1(7), ATF2(5), CALM2(1), EGFR(16), ELK1(1), GNAQ(1), GRB2(2), HRAS(1), JUN(1), MAP2K1(7), MAP2K2(2), MAP2K4(3), MAPK1(3), MAPK3(1), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), PAK1(2), PRKCA(8), PTK2(3), PTK2B(7), RAC1(9), RAF1(2), SHC1(1), SOS1(6), SRC(1), SYT1(12) 6690956 113 56 105 68 82 9 4 12 6 0 0.817 1.000 1.000 289 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(1), EIF4A1(3), EIF4A2(3), EIF4G1(8), EIF4G2(3), EIF4G3(11), GHR(16), IRS1(3), MAPK1(3), MAPK14(4), MAPK3(1), MKNK1(5), PABPC1(4), PDK2(4), PDPK1(3), PIK3CA(2), PIK3R1(2), PRKCA(8), PTEN(12), RPS6KB1(2) 5676879 98 56 96 32 51 12 7 10 18 0 0.0713 1.000 1.000 290 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(5), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2), CYP2C19(29), CYP2C9(28), DHRS1(2), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(3), EHHADH(5), HADHA(7), MYST3(10), MYST4(11), NAT6(2), PNPLA3(1), SH3GLB1(2) 6230641 130 56 124 86 95 11 5 10 9 0 0.894 1.000 1.000 291 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(3), CAPN1(1), CAPN2(2), CAPNS1(1), CXCR3(2), EGF(14), EGFR(16), HRAS(1), ITGA1(15), ITGB1(4), MAPK1(3), MAPK3(1), MYL2(4), MYLK(22), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PTK2(3), PXN(3), TLN1(10) 6496874 122 56 119 73 93 5 4 12 8 0 0.481 1.000 1.000 292 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(3), ANXA2(1), ANXA3(3), ANXA4(1), ANXA5(1), ANXA6(3), CYP11A1(9), EDN1(7), EDNRA(4), EDNRB(4), HSD11B1(8), PLA2G4A(8), PRL(1), PTGDR(7), PTGDS(2), PTGER2(5), PTGFR(13), PTGIR(3), PTGIS(9), PTGS1(14), PTGS2(6), TBXAS1(8) 4092694 120 56 115 53 91 11 3 7 8 0 0.00929 1.000 1.000 293 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(1), CDK5(3), CFL1(1), CHN1(3), LIMK1(4), MYL2(4), MYLK(22), NCF2(5), PAK1(2), PDGFRA(15), PIK3CA(2), PIK3R1(2), PLD1(7), PPP1R12B(5), RAC1(9), RALBP1(2), RPS6KB1(2), TRIO(10), VAV1(13), WASF1(1) 7017477 113 56 106 68 81 5 6 12 9 0 0.808 1.000 1.000 294 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ARHGAP1(1), ARHGAP4(1), ARHGAP5(9), ARHGAP6(5), ARHGEF1(1), ARHGEF11(10), ARHGEF5(12), ARPC1B(2), ARPC2(1), ARPC3(1), BAIAP2(3), CFL1(1), DIAPH1(6), GSN(5), LIMK1(4), MYL2(4), MYLK(22), OPHN1(4), PIP5K1A(6), PIP5K1B(15), PPP1R12B(5), ROCK1(3), SRC(1), TLN1(10), VCL(4) 9009225 138 56 136 67 100 9 5 16 8 0 0.117 1.000 1.000 295 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(4), CHUK(1), ELK1(1), FOS(1), IKBKB(2), JUN(1), LY96(3), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP3K14(1), MAPK14(4), MYD88(2), NFKB1(3), NFKBIA(2), PPARA(4), RELA(2), TLR10(9), TLR2(10), TLR3(7), TLR4(26), TLR6(3), TLR7(6), TLR9(8), TOLLIP(1), TRAF6(2) 7258829 112 56 110 68 76 11 3 15 7 0 0.739 1.000 1.000 296 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(1), APC(12), AXIN1(6), CCND1(1), CD14(4), CTNNB1(6), FZD1(1), GJA1(6), GNAI1(1), GSK3B(2), LBP(6), LEF1(1), LY96(3), MYD88(2), NFKB1(3), PDPK1(3), PIK3CA(2), PIK3R1(2), PPP2CA(1), RELA(2), TLR4(26), TOLLIP(1), WNT1(1) 6077365 93 55 89 58 62 8 4 10 9 0 0.913 1.000 1.000 297 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), EXT2(3), EXTL1(1), EXTL3(5), GLCE(7), HS2ST1(1), HS3ST1(8), HS3ST2(6), HS3ST3B1(2), HS3ST5(5), HS6ST1(3), HS6ST2(1), HS6ST3(9), NDST1(3), NDST3(14), NDST4(32) 4072715 101 55 99 53 66 7 4 11 13 0 0.243 1.000 1.000 298 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(3), ACTN1(2), ACTN2(14), ACTN3(5), BCAR1(3), BCR(6), CAPN1(1), CAPNS1(1), CAV1(1), CSK(1), FYN(5), GRB2(2), HRAS(1), ITGA1(15), ITGB1(4), JUN(1), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK3(1), PPP1R12B(5), PTK2(3), PXN(3), RAF1(2), RAP1A(1), ROCK1(3), SHC1(1), SOS1(6), SRC(1), TLN1(10), VCL(4), ZYX(4) 9337019 121 55 117 66 77 12 4 18 9 1 0.417 1.000 1.000 299 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(6), EGF(14), EGFR(16), GRB2(2), HRAS(1), MAP2K1(7), MAPK1(3), MAPK3(1), PTPRB(59), RAF1(2), RASA1(1), SHC1(1), SOS1(6), SPRY1(6), SPRY2(3), SPRY3(7), SPRY4(1), SRC(1) 5001420 137 55 126 62 106 10 3 11 7 0 0.261 1.000 1.000 300 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(1), AKT2(6), AKT3(3), CISH(2), GRB2(2), IARS(5), IL13RA1(3), IL2RG(2), IL4(1), IL4R(7), INPP5D(22), JAK1(4), JAK2(6), JAK3(5), NR0B2(6), PI3(6), PIK3CA(2), PPP1R13B(5), RPS6KB1(2), SERPINA4(10), SHC1(1), SOS1(6), SOS2(3), SRC(1), STAT6(5), TYK2(4) 7371587 120 55 119 57 84 9 6 11 10 0 0.310 1.000 1.000 301 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(3), BAX(1), BCL2(2), CASP1(3), CASP10(4), CASP2(1), CASP3(1), CASP4(1), CASP7(4), CASP8(2), CASP9(3), CD40(1), CD40LG(2), CRADD(1), CYCS(1), DAXX(5), DFFA(1), DFFB(2), FAS(3), FASLG(10), IKBKE(7), LTA(2), MCL1(2), NFKB1(3), NFKBIA(2), NGFR(6), NR3C1(2), NTRK1(10), PTPN13(8), RIPK1(1), SFRS2IP(5), TFG(2), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF1(6), TRAF2(2), TRAF3(3), TRAF6(2) 8684604 118 54 117 67 80 9 6 9 14 0 0.648 1.000 1.000 302 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(12), CD2(20), CD33(12), CD5(3), CSF2(2), IFNB1(5), IFNG(2), IL10(2), IL12A(2), IL12B(3), IL13(2), IL3(2), IL4(1), IL5(4), ITGAX(14), TLR2(10), TLR4(26), TLR7(6), TLR9(8) 3717732 136 54 130 65 100 11 2 9 14 0 0.00135 1.000 1.000 303 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(16), ELK1(1), GNAS(12), GRB2(2), HRAS(1), IGF1R(6), ITGB1(4), KLK2(1), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK3(1), MKNK1(5), MKNK2(2), MYC(2), NGFR(6), PDGFRA(15), PPP2CA(1), PTPRR(19), RAF1(2), RPS6KA1(4), RPS6KA5(4), SHC1(1), SOS1(6), SRC(1), STAT3(6) 6577341 130 54 125 67 90 10 7 17 6 0 0.370 1.000 1.000 304 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(11), ALDH1A3(2), ALDH3A1(4), ALDH3B1(2), ALDH3B2(5), AOC2(5), AOC3(6), DDC(7), EPX(5), GOT1(4), GOT2(2), HPD(3), LPO(11), MAOA(2), MAOB(7), MPO(6), MYST3(10), MYST4(11), NAT6(2), PNPLA3(1), PRDX6(2), SH3GLB1(2), TAT(12), TPO(30) 6877546 152 54 148 106 120 13 7 7 5 0 0.846 1.000 1.000 305 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(2), ALG10B(3), ALG12(1), ALG13(4), ALG2(3), ALG3(1), ALG5(1), ALG6(2), ALG8(3), ALG9(5), B4GALT1(1), B4GALT2(2), B4GALT3(2), DDOST(2), DOLPP1(3), DPAGT1(2), DPM1(1), FUT8(5), GANAB(5), MAN1A1(8), MAN1A2(3), MAN1B1(2), MAN1C1(6), MAN2A1(8), MGAT1(1), MGAT3(9), MGAT4A(5), MGAT5(2), MGAT5B(8), RFT1(1), RPN2(2), ST6GAL1(4), STT3B(3) 8480864 110 54 108 65 68 13 4 12 13 0 0.590 1.000 1.000 306 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(6), ACACA(16), ACACB(14), ACADM(5), ACAT2(1), ACSS2(3), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH6A1(2), ALDH7A1(3), ALDH9A1(2), EHHADH(5), HADHA(7), HIBCH(1), LDHA(2), LDHAL6A(1), LDHAL6B(6), LDHC(3), MCEE(1), MLYCD(2), MUT(4), PCCA(2), PCCB(1), SUCLG1(1), SUCLG2(2) 8000748 102 54 100 53 63 8 8 15 8 0 0.454 1.000 1.000 307 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(4), HLA-A(2), IL18(2), ITGB1(4), KLRC1(2), KLRC2(1), KLRC3(5), KLRC4(4), KLRD1(4), MAP2K1(7), MAPK3(1), PAK1(2), PIK3CA(2), PIK3R1(2), PTK2B(7), PTPN6(1), RAC1(9), SYK(11), VAV1(13) 3718696 83 54 74 41 62 4 2 8 7 0 0.430 1.000 1.000 308 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(6), ACACA(16), ACADL(2), ACADM(5), ACADSB(3), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH6A1(2), ALDH9A1(2), EHHADH(5), HADHA(7), LDHA(2), LDHC(3), MCEE(1), MLYCD(2), MUT(4), PCCA(2), PCCB(1), SUCLG1(1), SUCLG2(2) 6676922 91 54 90 43 59 7 7 13 5 0 0.396 1.000 1.000 309 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(8), DLG4(4), EPHB2(17), F2(6), F2RL1(10), F2RL2(4), JUN(1), MAP2K5(2), MAPK1(3), MAPK7(2), PLD1(7), PLD2(3), PLD3(1), PTK2(3), RAF1(2), RASAL1(10), SRC(1), TEC(7), VAV1(13) 5485370 104 54 101 72 70 8 4 15 7 0 0.898 1.000 1.000 310 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(4), AKT1(1), AKT2(6), AKT3(3), DAG1(3), GNAQ(1), ITPKB(5), ITPR1(19), ITPR2(10), ITPR3(4), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PDK1(1), PHKA2(6), PIK3CB(10), PITX2(1), PLD1(7), PLD2(3), PLD3(1) 8973114 97 54 95 68 52 11 7 15 12 0 0.878 1.000 1.000 311 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(1), BCL2(2), EGFR(16), IGF1R(6), MYC(2), POLR2A(10), PPP2CA(1), PRKCA(8), RB1(3), TEP1(20), TERT(4), TNKS(5), TP53(26) 5641661 104 54 100 57 62 9 7 11 13 2 0.559 1.000 1.000 312 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(1), APC(12), ATF2(5), AXIN1(6), BMP10(8), BMP2(4), BMP4(2), BMP5(12), BMP7(2), BMPR1A(1), BMPR2(4), CHRD(8), CTNNB1(6), FZD1(1), GATA4(2), GSK3B(2), MEF2C(2), MYL2(4), NOG(1), NPPA(1), NPPB(4), RFC1(2), TGFB2(1), TGFB3(1), TGFBR2(5), TGFBR3(5), WNT1(1) 7238046 103 53 99 60 74 9 5 5 10 0 0.843 1.000 1.000 313 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(6), CARM1(4), CCND1(1), CREBBP(14), EP300(8), ERCC3(3), ESR1(2), GRIP1(4), GTF2A1(2), GTF2F1(2), HDAC1(1), HDAC3(3), HDAC4(8), HDAC5(3), HDAC6(2), MEF2C(2), NCOR2(15), NR0B1(2), NRIP1(5), PELP1(9), POLR2A(10), TBP(4) 9084997 110 53 109 53 79 5 8 10 8 0 0.381 1.000 1.000 314 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(3), GALNS(2), GBA(2), GLB1(5), GUSB(3), HEXA(5), HEXB(2), HGSNAT(4), HPSE(6), HPSE2(3), HYAL2(1), IDS(5), IDUA(4), LCT(31), MAN2B1(6), MAN2B2(4), MAN2C1(1), MANBA(4), NAGLU(3), NEU1(4), NEU2(12), NEU3(2), NEU4(7), SPAM1(14) 6833119 133 53 132 75 99 10 3 13 8 0 0.434 1.000 1.000 315 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(5), DAXX(5), DDIT3(1), ELK1(1), GRB2(2), HMGN1(1), HRAS(1), HSPB1(2), HSPB2(1), MAP2K4(3), MAP2K6(2), MAP3K5(11), MAP3K9(17), MAPK14(4), MAPKAPK2(2), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), MKNK1(5), MYC(2), PLA2G4A(8), RAC1(9), RIPK1(1), RPS6KA5(4), SHC1(1), STAT1(2), TGFB2(1), TGFB3(1), TRAF2(2) 7272185 102 53 98 39 70 10 3 11 8 0 0.106 1.000 1.000 316 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(1), ERCC3(3), GTF2A2(1), GTF2B(1), GTF2E2(4), GTF2F2(2), GTF2H1(3), GTF2H4(1), MNAT1(2), POLR1A(7), POLR1B(5), POLR2A(10), POLR2B(11), POLR2E(1), POLR2F(1), POLR2H(2), POLR2J(1), POLR3B(12), POLR3D(1), POLR3E(2), POLR3K(1), TAF6(2), TAF7(1), TAF9(1), TBP(4) 7062863 80 53 79 28 51 9 6 11 3 0 0.0578 1.000 1.000 317 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), ATF1(3), CREB5(7), DUSP10(6), EEF2K(2), ELK1(1), HSPB1(2), IL1R1(7), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP3K10(5), MAP3K4(11), MAP3K5(11), MAPK1(3), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(4), MAPKAPK2(2), MKNK1(5), MKNK2(2), NFKB1(3), NR2C2(2), SRF(1), TRAF6(2) 6662487 95 53 94 53 65 8 3 12 7 0 0.623 1.000 1.000 318 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(8), EEF1B2(1), EEF1G(1), EEF2(2), EEF2K(2), EIF1AX(2), EIF2AK1(2), EIF2AK2(2), EIF2AK3(7), EIF2B1(6), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(1), EIF2S1(1), EIF4A1(3), EIF4A2(3), EIF4G1(8), EIF4G3(11), ETF1(1), GSPT2(2), KIAA0664(3), PABPC1(4), PABPC3(8), PAIP1(7), SLC35A4(3) 8755287 93 53 88 48 53 7 5 12 16 0 0.727 1.000 1.000 319 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(3), CR1(35), CR2(20), FCGR2B(1), HLA-DRA(7), HLA-DRB1(2), ICAM1(2), ITGAL(17), ITGB2(10), PTPRC(18) 3007705 115 52 108 47 86 6 1 12 10 0 0.0991 1.000 1.000 320 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(3), UCHL1(4), UCHL3(2), UGT1A1(1), UGT1A10(13), UGT1A3(7), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(9), UGT1A8(3), UGT1A9(6), UGT2B15(18), UGT2B4(23) 3557943 102 52 94 52 71 9 5 4 13 0 0.202 1.000 1.000 321 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(11), ALDH1A3(2), ALDH3A1(4), ALDH3B1(2), ALDH3B2(5), AOC2(5), AOC3(6), DDC(7), EPX(5), GOT1(4), GOT2(2), HPD(3), LPO(11), MAOA(2), MAOB(7), MPO(6), PRDX1(1), PRDX2(2), PRDX6(2), TAT(12), TPO(30) 4392207 129 52 126 85 104 10 6 5 4 0 0.311 1.000 1.000 322 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(4), ABAT(6), ADSL(6), ADSS(1), AGXT(8), AGXT2(13), ASL(3), ASNS(7), ASPA(3), CAD(12), CRAT(4), DARS(2), DDO(4), GAD1(7), GAD2(4), GOT1(4), GOT2(2), GPT(3), NARS(2), PC(6) 5252387 101 51 98 56 70 11 7 10 3 0 0.263 1.000 1.000 323 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(9), DIAPH1(6), FYN(5), GSN(5), HRAS(1), ITGA1(15), ITGB1(4), MAP2K1(7), MAPK1(3), MAPK3(1), MYL2(4), MYLK(22), PIK3CA(2), PIK3R1(2), PTK2(3), PXN(3), RAF1(2), ROCK1(3), SHC1(1), SRC(1), TLN1(10) 7479374 109 51 103 52 78 9 3 15 4 0 0.261 1.000 1.000 324 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(1), GHR(16), GRB2(2), HRAS(1), INSR(13), IRS1(3), JAK2(6), MAP2K1(7), MAPK1(3), MAPK3(1), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(8), PTPN6(1), RAF1(2), RPS6KA1(4), SHC1(1), SLC2A4(6), SOS1(6), SRF(1), STAT5A(2), STAT5B(4) 6651337 96 51 92 51 63 9 4 15 5 0 0.466 1.000 1.000 325 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(23), ACE2(5), AGT(3), AGTR1(7), AGTR2(3), ANPEP(12), CMA1(4), CPA3(12), CTSA(3), CTSG(4), ENPEP(19), LNPEP(9), MAS1(2), MME(12), NLN(2), REN(8), THOP1(4) 4213120 132 51 128 71 97 13 5 6 11 0 0.144 1.000 1.000 326 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(22), ATP4B(1), ATP5O(3), ATP6AP1(1), ATP6V0A1(5), ATP6V0A4(12), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C2(6), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), ATP7A(1), ATP7B(14), COX10(4), COX5B(1), COX6B1(1), COX7B(1), COX8A(1), NDUFA10(1), NDUFB2(1), NDUFB5(1), NDUFB6(2), NDUFS2(1), NDUFV1(1), PPA2(2), SDHA(1), UQCRC1(3), UQCRFS1(2) 7707115 107 51 107 76 69 7 10 11 10 0 0.935 1.000 1.000 327 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(3), CALM2(1), GNAQ(1), GRB2(2), HRAS(1), JUN(1), MAP2K1(7), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAPK1(3), MAPK14(4), MAPK3(1), PAK1(2), PLCG1(4), PRKCA(8), PTK2B(7), RAC1(9), RAF1(2), SHC1(1), SOS1(6), SRC(1), SYT1(12) 5696004 85 51 77 50 61 7 3 10 4 0 0.699 1.000 1.000 328 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(17), AKT1(1), BAX(1), BCL2(2), CSF2RB(14), IGF1(7), IGF1R(6), IL3(2), IL3RA(4), KIT(7), KITLG(6), PIK3CA(2), PIK3R1(2), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4) 4382716 88 50 88 54 61 7 3 7 10 0 0.565 1.000 1.000 329 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(16), FOS(1), HRAS(1), JUN(1), MAP2K1(7), MAPK1(3), MAPK3(1), MYC(2), NFKB1(3), NFKBIA(2), PLCB1(33), PRKCA(8), RAF1(2), RELA(2), TNF(1) 3127462 83 50 75 35 62 6 4 6 5 0 0.0477 1.000 1.000 330 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(5), AZIN1(1), BTG1(2), CLOCK(2), CRY1(3), CRY2(2), EIF4G2(3), ETV6(8), GFRA1(6), GSTM3(2), HERPUD1(2), HSPA8(4), KLF9(2), MYF6(7), NCKAP1(2), NCOA4(1), NR1D2(5), PER1(4), PER2(10), PIGF(2), PPP1R3C(2), PPP2CB(2), PURA(1), SF3A3(2), TOB1(2), TUBB3(3), UCP3(3), UGP2(1), ZFR(3) 7321232 92 50 92 48 50 10 6 18 8 0 0.841 1.000 1.000 331 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(3), CRK(2), CXCL12(1), CXCR4(1), GNAI1(1), GNAQ(1), HRAS(1), MAP2K1(7), MAPK1(3), MAPK3(1), NFKB1(3), PIK3C2G(32), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(8), PTK2(3), PTK2B(7), PXN(3), RAF1(2), RELA(2) 5503459 89 50 83 49 68 4 0 10 7 0 0.545 1.000 1.000 332 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(12), CALCR(13), CALCRL(8), CD97(5), CRHR1(2), CRHR2(1), ELTD1(17), EMR1(17), EMR2(1), GHRHR(4), GIPR(2), GLP1R(5), GLP2R(7), GPR64(1), LPHN1(4), LPHN2(24), LPHN3(10), SCTR(5), VIPR1(3), VIPR2(4) 5263678 145 50 135 112 110 9 5 7 14 0 0.798 1.000 1.000 333 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(11), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH3B1(2), ALDH3B2(5), ALDH9A1(2), AOC2(5), AOC3(6), ASPA(3), CNDP1(7), DDC(7), HAL(8), HARS(3), HDC(8), MAOA(2), MAOB(7), PRPS1(1), PRPS2(1) 4869720 102 50 102 73 74 11 6 6 5 0 0.762 1.000 1.000 334 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(6), ADC(3), ALDH4A1(5), ALDH5A1(7), CAD(12), CPS1(13), EPRS(6), GAD1(7), GAD2(4), GCLC(4), GCLM(1), GFPT1(1), GFPT2(4), GLS(1), GLS2(3), GLUD1(1), GLUD2(1), GMPS(3), GOT1(4), GOT2(2), GPT(3), GSR(2), GSS(5), NADSYN1(2), QARS(6) 7926697 106 50 103 70 62 13 8 16 7 0 0.862 1.000 1.000 335 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(8), ABCC2(7), ABCG2(6), BCHE(6), CES1(12), CES2(3), CYP3A4(13), CYP3A5(4), UGT1A1(1), UGT1A10(13), UGT1A3(7), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(9), UGT1A8(3), UGT1A9(6) 4600376 109 50 104 49 75 8 6 9 11 0 0.0228 1.000 1.000 336 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(12), AXIN1(6), CREBBP(14), CTNNB1(6), EP300(8), FZD1(1), GSK3B(2), HDAC1(1), LDB1(1), LEF1(1), PITX2(1), TRRAP(29), WNT1(1) 6673218 83 50 81 52 46 8 7 11 11 0 0.955 1.000 1.000 337 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(20), F2(6), F2R(4), FGA(20), FGB(7), FGG(4), PLAT(2), PLAU(2), PLG(20), SERPINB2(8), SERPINE1(2) 2675723 95 49 93 40 76 6 3 5 5 0 0.145 1.000 1.000 338 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(17), CALM2(1), ELK1(1), FOS(1), GNAI1(1), GNAQ(1), GNAS(12), HRAS(1), JUN(1), MAP2K1(7), MAPK3(1), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), PLCG1(4), PPP3CA(4), PPP3CB(1), PPP3CC(1), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(8), RAF1(2), SYT1(12) 6953437 123 49 119 78 91 9 4 10 9 0 0.852 1.000 1.000 339 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(1), CABIN1(3), CALM2(1), CAMK1(4), CAMK1G(9), HDAC5(3), IGF1(7), IGF1R(6), INSR(13), MAP2K6(2), MAPK14(4), MAPK7(2), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), NFATC1(13), NFATC2(6), PIK3CA(2), PIK3R1(2), PPP3CA(4), PPP3CB(1), PPP3CC(1), SYT1(12) 6985715 104 49 104 64 75 9 3 13 4 0 0.690 1.000 1.000 340 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(1), IFNB1(5), IKBKB(2), IL1A(3), IL1B(5), IL1R1(7), IL1RAP(3), IL1RN(6), IRAK2(10), IRAK3(7), JUN(1), MAP2K3(4), MAP2K6(2), MAP3K14(1), MAPK14(4), MYD88(2), NFKB1(3), NFKBIA(2), RELA(2), TGFB2(1), TGFB3(1), TNF(1), TOLLIP(1), TRAF6(2) 5905110 76 49 74 46 49 8 1 8 10 0 0.700 1.000 1.000 341 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(17), ARHGEF1(1), F2(6), F2R(4), GNA12(2), GNA13(1), GNAI1(1), GNAQ(1), PIK3CA(2), PIK3R1(2), PLCB1(33), PPP1R12B(5), PRKCA(8), PTK2B(7), ROCK1(3) 5179297 93 49 89 49 71 6 2 8 6 0 0.374 1.000 1.000 342 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(2), ESR2(5), PDE1A(22), PDE1B(8), PLCB1(33), PLCB2(7), PRL(1), TRH(3), VIP(3) 2202188 84 49 76 43 70 2 1 5 6 0 0.169 1.000 1.000 343 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), DAG1(3), ITPKB(5), ITPR1(19), ITPR2(10), ITPR3(4), NFAT5(3), PDE6A(9), PDE6B(11), PDE6C(18), PDE6D(2), PDE6G(2), SLC6A13(14), TF(5) 7140232 117 49 113 68 84 8 3 9 13 0 0.267 1.000 1.000 344 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(5), ABAT(6), ACADS(2), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH5A1(7), ALDH9A1(2), EHHADH(5), GAD1(7), GAD2(4), HADHA(7), HMGCL(2), L2HGDH(2), OXCT1(3), PDHA1(1), PDHA2(9), PDHB(1) 5206475 88 48 87 41 58 8 2 10 10 0 0.133 1.000 1.000 345 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(3), CSNK1D(1), DRD1(8), DRD2(9), GRM1(9), PLCB1(33), PPP1CA(1), PPP1R1B(1), PPP2CA(1), PPP3CA(4), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4) 3192471 87 48 84 57 69 0 3 8 7 0 0.658 1.000 1.000 346 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(17), AKT1(1), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), GNAS(12), GRB2(2), HRAS(1), MAPK1(3), MAPK14(4), MAPK3(1), PIK3CA(2), PIK3R1(2), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(8), RAC1(9), RPS6KA1(4), RPS6KA5(4), SOS1(6) 5784333 105 48 100 61 77 5 4 10 9 0 0.729 1.000 1.000 347 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(2), CDT1(1), DIAPH2(4), MCM10(6), MCM2(8), MCM3(7), MCM4(3), MCM5(2), MCM6(3), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(2), ORC5L(1), ORC6L(2), PCNA(1), POLA2(6), POLD1(3), POLD2(2), POLD3(3), POLE(10), POLE2(1), PRIM1(1), RFC1(2), RFC3(1), RPA1(3), RPA2(1), RPA4(2), UBC(4) 10161802 86 48 86 46 56 5 4 11 10 0 0.477 1.000 1.000 348 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(3), ACP2(2), ACP5(3), ACP6(8), ACPP(6), ALPI(3), ALPL(6), ALPP(6), ALPPL2(7), CMBL(1), CYP3A4(13), CYP3A43(10), CYP3A5(4), CYP3A7(14), DHRS1(2), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(3), PON1(12), PON2(1), PON3(4) 3598721 116 48 112 40 85 7 6 8 10 0 0.000510 1.000 1.000 349 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(8), ALDOC(1), FBP1(1), FBP2(1), GOT1(4), GOT2(2), GPT(3), MDH1(1), MDH2(2), ME1(14), ME3(6), PGK1(2), PGK2(17), PKLR(6), PKM2(5), TKT(5), TKTL1(1), TKTL2(14) 4069059 94 48 91 54 72 7 4 5 6 0 0.144 1.000 1.000 350 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(2), GALNT10(4), GALNT2(4), GALNT3(2), GALNT4(2), GALNT6(13), GALNT7(5), GALNT8(14), GALNT9(3), GCNT1(4), ST3GAL1(5), ST3GAL4(1), WBSCR17(24) 2907672 83 48 80 39 62 5 1 7 8 0 0.169 1.000 1.000 351 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(3), BCL2(2), BIRC2(4), BIRC3(6), CASP10(4), CASP3(1), CASP7(4), CASP8(2), CASP9(3), CFLAR(3), CHUK(1), CYCS(1), DFFA(1), DFFB(2), GAS2(5), LMNA(3), MAP3K14(1), NFKB1(3), NFKBIA(2), RELA(2), RIPK1(1), SPTAN1(4), TNFRSF10A(4), TNFRSF10B(1), TNFRSF25(4), TNFSF10(5), TNFSF12(1), TRAF2(2) 6706859 75 47 75 50 49 8 8 7 3 0 0.852 1.000 1.000 352 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(6), ACO1(2), ACO2(2), CLYBL(2), CS(1), DLD(1), FH(3), IDH1(7), IDH3A(3), IDH3G(2), MDH1(1), MDH2(2), OGDH(8), OGDHL(22), PC(6), PCK1(20), PCK2(3), SDHA(1), SDHC(2), SUCLG1(1), SUCLG2(2) 6026956 97 47 90 49 73 3 6 8 7 0 0.185 1.000 1.000 353 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLA2(6), POLD1(3), POLD2(2), POLD3(3), POLE(10), POLE2(1), POLG(4), POLG2(4), POLH(3), POLI(1), POLK(4), POLL(7), POLM(2), POLQ(15), PRIM1(1), PRIM2(8), REV1(3), REV3L(8) 8123168 86 47 85 31 48 5 5 16 12 0 0.153 1.000 1.000 354 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(1), BCL2(2), CBL(6), CFLAR(3), E2F1(5), FOS(1), GRB2(2), HRAS(1), IL2RA(4), IL2RB(7), IL2RG(2), IRS1(3), JAK1(4), JAK3(5), MAPK1(3), MAPK3(1), MYC(2), PIK3CA(2), PIK3R1(2), PPIA(1), PTPN6(1), RAF1(2), RPS6KB1(2), SHC1(1), SOCS3(2), SOS1(6), STAT5A(2), STAT5B(4), SYK(11) 7207496 88 47 87 50 56 8 10 8 6 0 0.698 1.000 1.000 355 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(1), EIF4A1(3), EIF4A2(3), EIF4B(1), EIF4G1(8), EIF4G2(3), EIF4G3(11), FKBP1A(2), MKNK1(5), PDK2(4), PDPK1(3), PIK3CA(2), PIK3R1(2), PPP2CA(1), PTEN(12), RPS6(1), RPS6KB1(2), TSC1(3), TSC2(7) 5551204 74 47 73 28 35 8 7 9 15 0 0.271 1.000 1.000 356 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(12), CAMP(1), CASP3(1), CREB5(7), DAG1(3), EPHB2(17), FOS(1), GNAQ(1), ITPKB(5), JUN(1), MAP2K4(3), MAP2K7(2), MAPK1(3), MAPK10(6), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(6), MAPK9(1) 5694642 77 47 77 50 53 5 4 8 7 0 0.882 1.000 1.000 357 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(17), CD3D(5), CD3E(2), CD4(4), CREBBP(14), CSK(1), GNAS(12), HLA-DRA(7), HLA-DRB1(2), LCK(9), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PTPRC(18), ZAP70(4) 4532775 112 46 109 66 82 8 4 9 9 0 0.638 1.000 1.000 358 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(17), CD3D(5), CD3E(2), CD4(4), CREBBP(14), CSK(1), GNAS(12), HLA-DRA(7), HLA-DRB1(2), LCK(9), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PTPRC(18), ZAP70(4) 4532775 112 46 109 66 82 8 4 9 9 0 0.638 1.000 1.000 359 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSD(2), ARSE(4), GAL3ST1(7), GALC(1), GBA(2), GLA(1), GLB1(5), LCT(31), NEU1(4), NEU2(12), NEU3(2), NEU4(7), PPAP2B(4), PPAP2C(6), SMPD1(1), SPTLC2(5), UGCG(1) 4795831 95 46 93 64 74 9 2 7 3 0 0.808 1.000 1.000 360 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(11), ADC(3), AGMAT(3), ALDH18A1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2), AOC2(5), AOC3(6), ARG1(1), ARG2(1), ASL(3), ASS1(3), CPS1(13), GATM(2), MAOA(2), MAOB(7), ODC1(2), OTC(2), SMS(1) 5839708 85 46 84 59 56 9 7 4 9 0 0.747 1.000 1.000 361 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(16), PGAP1(2), PIGB(3), PIGC(1), PIGF(2), PIGG(9), PIGK(4), PIGL(2), PIGN(2), PIGO(9), PIGQ(6), PIGS(1), PIGT(1), PIGU(4), PIGV(7), PIGW(1), PIGX(1), PIGZ(1) 4798954 72 46 70 31 47 5 5 10 5 0 0.0866 1.000 1.000 362 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(5), CCR2(8), CCR3(8), CCR4(5), CCR5(5), CCR7(3), CD4(4), CSF2(2), CXCR3(2), CXCR4(1), IFNG(2), IFNGR1(3), IFNGR2(2), IL12A(2), IL12B(3), IL12RB1(9), IL12RB2(3), IL18R1(14), IL2(4), IL4(1), IL4R(7), IL5(4), TGFB2(1), TGFB3(1) 4005065 99 46 97 57 74 10 0 6 9 0 0.135 1.000 1.000 363 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(26), AKT1(1), ATM(10), BAX(1), CDKN1A(2), CSNK1A1(2), CSNK1D(1), HIC1(1), HIF1A(1), IGFBP3(1), MDM2(2), NFKBIB(1), NQO1(1), TP53(26) 4177354 76 46 69 33 45 7 2 8 14 0 0.414 1.000 1.000 364 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K4(3), MAP2K7(2), MAPK1(3), MAPK10(6), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(4), MAPK3(1), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(6), MAPK9(1), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PIK3CA(2), PIK3CD(2), PIK3R1(2), SYT1(12), TRAF2(2), TRAF3(3), TRAF5(5), TRAF6(2) 6687999 81 46 81 61 54 7 5 11 4 0 0.909 1.000 1.000 365 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(3), ATM(10), BRCA1(6), CDKN1A(2), CHEK1(1), JUN(1), MDM2(2), MRE11A(3), NFKB1(3), NFKBIA(2), RAD50(3), RBBP8(3), RELA(2), TP53(26), TP73(4) 5955600 71 45 67 31 40 6 4 8 13 0 0.572 1.000 1.000 366 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(4), AKR1D1(14), CYP11A1(9), CYP11B1(8), CYP11B2(9), CYP17A1(5), CYP21A2(12), HSD11B1(8), HSD3B1(4), HSD3B2(9) 1967878 82 45 77 41 57 7 3 8 7 0 0.0251 1.000 1.000 367 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), EGF(14), EGFR(16), ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(4), JUN(1), MAP2K1(7), MAP2K4(3), MAPK3(1), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(8), RAF1(2), RASA1(1), SHC1(1), SOS1(6), SRF(1), STAT1(2), STAT3(6), STAT5A(2) 7495909 89 45 85 54 59 8 4 11 7 0 0.896 1.000 1.000 368 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(8), CSF1R(9), DDX20(7), E2F1(5), ETS1(3), ETS2(8), ETV3(3), FOS(1), HDAC5(3), HRAS(1), JUN(1), NCOR2(15), RBL1(5), RBL2(2), SIN3A(5), SIN3B(7) 5207449 83 45 83 55 57 6 0 13 7 0 0.848 1.000 1.000 369 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(2), CASP10(4), CASP3(1), CASP7(4), CASP8(2), CFLAR(3), DAXX(5), DFFA(1), DFFB(2), FAF1(3), JUN(1), LMNA(3), LMNB1(1), LMNB2(4), MAP2K4(3), PAK1(2), PAK2(2), PRKDC(13), PTPN13(8), RB1(3), RIPK2(1), SPTAN1(4) 8238204 72 45 72 39 38 7 9 13 3 2 0.768 1.000 1.000 370 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(6), ALDH4A1(5), ALDH5A1(7), CAD(12), CPS1(13), EPRS(6), GAD1(7), GAD2(4), GCLC(4), GCLM(1), GFPT1(1), GLS(1), GLS2(3), GLUD1(1), GMPS(3), GOT1(4), GOT2(2), GPT(3), GSS(5), NADSYN1(2), QARS(6) 6664465 96 45 93 55 56 12 8 14 6 0 0.653 1.000 1.000 371 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(5), ALDOA(1), ALDOB(8), ALDOC(1), FBP1(1), FBP2(1), FPGT(2), FUK(1), GMDS(4), GMPPA(1), GMPPB(2), HK1(1), HK2(5), HK3(10), HSD3B7(1), KHK(1), LHPP(1), MPI(1), MTMR1(3), MTMR2(1), MTMR6(2), PFKFB1(2), PFKFB2(3), PFKFB3(2), PFKFB4(4), PFKL(2), PGM2(5), RDH12(1), RDH13(3), SORD(1), TSTA3(2) 7392840 80 45 77 56 57 10 4 4 5 0 0.559 1.000 1.000 372 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(4), AKR1D1(14), CYP11A1(9), CYP11B1(8), CYP11B2(9), CYP17A1(5), CYP21A2(12), HSD11B1(8), HSD3B1(4), HSD3B2(9) 1967878 82 45 77 41 57 7 3 8 7 0 0.0251 1.000 1.000 373 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(4), CARM1(4), CBS(5), GGT1(4), HEMK1(1), LCMT1(4), MARS(5), MARS2(3), MAT1A(4), MAT2B(1), METTL2B(6), PAPSS1(2), PAPSS2(4), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(7), SCLY(2), SEPHS1(4), SEPHS2(1), WBSCR22(1) 5036454 75 45 74 28 45 7 4 12 7 0 0.0421 1.000 1.000 374 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(2), GTF2A1L(3), GTF2A2(1), GTF2B(1), GTF2E2(4), GTF2F1(2), GTF2F2(2), GTF2H1(3), GTF2H3(1), GTF2H4(1), GTF2I(2), GTF2IRD1(4), TAF1(6), TAF1L(36), TAF2(2), TAF4(6), TAF5L(3), TAF6(2), TAF6L(3), TAF7(1), TAF7L(4), TAF9(1), TBPL1(1), TBPL2(2) 7282184 93 45 92 42 62 10 4 12 5 0 0.449 1.000 1.000 375 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(8), ANAPC10(1), ANAPC2(3), ANAPC4(1), ANAPC5(4), ANAPC7(4), BTRC(4), CDC16(1), CDC27(6), CUL1(4), CUL2(2), CUL3(3), FBXW11(4), FBXW7(9), FZR1(3), ITCH(2), SMURF1(1), SMURF2(5), TCEB1(1), UBA1(2), UBE2D3(3), UBE2E1(1), UBE2E2(2), VHL(2), WWP1(1), WWP2(5) 7990437 82 45 81 39 50 4 6 13 8 1 0.710 1.000 1.000 376 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(9), ARHGEF1(1), GNA12(2), GNA13(1), GNAQ(1), MYL2(4), MYLK(22), PLCB1(33), PPP1R12B(5), PRKCA(8), ROCK1(3) 4175455 89 45 83 41 74 3 2 6 4 0 0.202 1.000 1.000 377 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(3), DAB1(30), FYN(5), LRP8(3), RELN(46), VLDLR(4) 2800281 91 45 88 41 69 4 2 7 9 0 0.376 1.000 1.000 378 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(12), AXIN1(6), BTRC(4), CCND1(1), CREBBP(14), CSNK1A1(2), CSNK1D(1), CSNK2A1(1), CTNNB1(6), FZD1(1), GSK3B(2), HDAC1(1), MYC(2), NLK(4), PPARD(2), PPP2CA(1), TLE1(2), WIF1(5), WNT1(1) 5848071 68 45 67 36 37 5 6 7 13 0 0.815 1.000 1.000 379 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT2(3), AGPAT3(3), AGPAT4(5), AGPAT6(2), AGPS(3), CHPT1(1), ENPP6(8), PAFAH1B1(2), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(2), PLA2G12B(3), PLA2G2A(2), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(14), PLA2G4A(8), PLA2G6(7), PLD1(7), PLD2(3), PPAP2B(4), PPAP2C(6) 4683854 95 44 93 47 63 8 3 10 11 0 0.285 1.000 1.000 380 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(10), ABP1(11), AOC2(5), AOC3(6), CES1(12), CES7(10), DDHD1(5), LIPA(1), MYST3(10), MYST4(11), NAT6(2), PLA1A(4), PNPLA3(1), PPME1(1), PRDX6(2), SH3GLB1(2) 5098401 93 44 92 50 73 4 7 4 5 0 0.604 1.000 1.000 381 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(3), AASDH(4), AASDHPPT(1), AASS(1), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), BBOX1(3), DOT1L(5), EHHADH(5), EHMT1(6), EHMT2(4), GCDH(3), HADHA(7), PLOD1(1), PLOD2(5), PLOD3(1), SHMT2(2), TMLHE(1) 7374880 79 44 78 44 51 9 2 10 7 0 0.451 1.000 1.000 382 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(3), GTF2A1(2), GTF2B(1), GTF2F1(2), HDAC3(3), NCOA1(8), NCOA2(12), NCOA3(8), NCOR2(15), POLR2A(10), RARA(1), RXRA(1), TBP(4) 4978884 70 44 68 33 54 3 4 6 3 0 0.329 1.000 1.000 383 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(3), ACTN1(2), ACTN2(14), ACTN3(5), CAPN1(1), CAPNS1(1), ITGA1(15), ITGB1(4), ITGB3(9), PTK2(3), PXN(3), RAC1(9), SPTAN1(4), SRC(1), TLN1(10) 5635202 84 44 79 47 59 5 3 9 7 1 0.215 1.000 1.000 384 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(17), ADRB2(1), CFTR(29), GNAS(12), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), SLC9A3R1(3) 2587955 79 43 76 51 59 4 4 6 6 0 0.718 1.000 1.000 385 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(14), EGFR(16), MAP2K1(7), MAPK14(4), NCOR2(15), RARA(1), RXRA(1), THRA(1), THRB(12) 3431333 71 43 68 45 51 6 1 10 3 0 0.827 1.000 1.000 386 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(4), F2(6), F2R(4), F5(20), F7(2), FGA(20), FGB(7), FGG(4), PROC(7), PROS1(9), SERPINC1(5), TFPI(5) 3292580 93 43 90 43 69 8 5 5 6 0 0.321 1.000 1.000 387 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(2), CHIA(8), CHIT1(7), CTBS(4), CYB5R1(1), GFPT1(1), GFPT2(4), GNE(3), HEXA(5), HEXB(2), HK1(1), HK2(5), HK3(10), LHPP(1), MTMR1(3), MTMR2(1), MTMR6(2), NANS(1), PGM3(1), RENBP(2), UAP1(1) 5744964 65 43 63 39 45 5 3 6 6 0 0.627 1.000 1.000 388 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 GALNS(2), GLB1(5), GUSB(3), HEXA(5), HEXB(2), HGSNAT(4), HPSE(6), HPSE2(3), HYAL2(1), IDS(5), IDUA(4), LCT(31), NAGLU(3), SPAM1(14) 4073106 88 43 87 52 63 6 2 9 8 0 0.613 1.000 1.000 389 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(1), EIF2B5(1), EIF2S1(1), GSK3B(2), IGF1(7), IGF1R(6), INPPL1(11), PDK2(4), PDPK1(3), PIK3CA(2), PIK3R1(2), PPP2CA(1), PTEN(12), RPS6(1), RPS6KB1(2) 3934542 56 43 55 23 27 6 7 6 10 0 0.361 1.000 1.000 390 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(3), ADCY1(17), CDC25C(3), GNAI1(1), GNAS(12), HRAS(1), MAPK1(3), MAPK3(1), MYT1(15), PIN1(1), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), RPS6KA1(4), SRC(1) 4104040 79 43 79 54 60 3 2 6 8 0 0.745 1.000 1.000 391 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(26), ABCB11(35), ABCB4(9), ABCC1(8), ABCC3(20) 2851612 98 43 94 51 68 9 2 6 13 0 0.0233 1.000 1.000 392 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(4), DYRK1B(2), GLI2(23), GLI3(8), GSK3B(2), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), SHH(2), SMO(6), SUFU(2) 3320172 66 43 64 37 48 7 3 4 4 0 0.410 1.000 1.000 393 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(8), AGT(3), AGTR2(3), EDN1(7), EDNRA(4), EDNRB(4), EGF(14), EGFR(16), FOS(1), HRAS(1), JUN(1), MYC(2), NFKB1(3), PLCG1(4), PRKCA(8), RELA(2) 4118859 81 42 79 51 62 5 2 7 5 0 0.706 1.000 1.000 394 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(6), CSF1R(9), EGF(14), EGFR(16), GRB2(2), MET(12), PDGFRA(15), PRKCA(8), SH3GLB1(2), SH3KBP1(3), SRC(1) 3911540 88 42 87 60 60 6 3 8 11 0 0.941 1.000 1.000 395 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(12), G6PD(2), GCLC(4), GCLM(1), GGT1(4), GPX1(2), GPX3(2), GPX5(6), GPX6(7), GSR(2), GSS(5), GSTA1(5), GSTA2(1), GSTA3(1), GSTA5(2), GSTK1(1), GSTM1(1), GSTM2(2), GSTM3(2), GSTM4(1), GSTM5(3), GSTT1(1), IDH1(7), MGST1(1), MGST2(1), OPLAH(8) 4376349 84 42 79 51 56 7 2 14 5 0 0.430 1.000 1.000 396 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(15), CD38(3), ENPP1(9), ENPP3(10), NADK(2), NADSYN1(2), NMNAT2(3), NMNAT3(4), NNMT(8), NNT(3), NT5C1A(1), NT5C1B(16), NT5C2(1), NT5C3(2), NT5E(4), NT5M(1), NUDT12(1), QPRT(5) 4324875 90 42 87 57 59 9 5 8 9 0 0.848 1.000 1.000 397 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(3), BAIAP2(3), CASP1(3), CASP3(1), CASP7(4), CASP8(2), INSR(13), ITCH(2), MAGI1(19), MAGI2(16), RERE(12), WWP1(1), WWP2(5) 4835681 84 42 83 43 59 5 3 13 3 1 0.631 1.000 1.000 398 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), IL2(4), IL2RA(4), IL2RB(7), IL2RG(2), JAK1(4), JAK3(5), JUN(1), LCK(9), MAP2K1(7), MAPK3(1), RAF1(2), SHC1(1), SOS1(6), STAT5A(2), STAT5B(4), SYK(11) 4603974 76 42 72 35 51 7 4 9 5 0 0.210 1.000 1.000 399 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(2), CS(1), DLAT(2), DLD(1), FH(3), IDH3A(3), IDH3G(2), MDH1(1), MDH2(2), OGDH(8), PC(6), PDHA1(1), PDHA2(9), PDHB(1), PDHX(2), PDK1(1), PDK2(4), PDK3(3), PDK4(7), PDP2(4), SDHA(1), SDHC(2), SUCLG1(1), SUCLG2(2) 5717506 69 42 67 31 47 2 5 6 9 0 0.225 1.000 1.000 400 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(1), CREBBP(14), EP300(8), IKBKB(2), IL1B(5), IL8(1), MAP2K3(4), MAP2K6(2), MAP3K14(1), MAPK11(1), MAPK14(4), MYD88(2), NFKB1(3), NFKBIA(2), NR3C1(2), RELA(2), TGFBR2(5), TLR2(10), TNF(1) 5960966 70 42 70 42 46 10 3 6 5 0 0.829 1.000 1.000 401 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(5), GBA3(6), LPO(11), MPO(6), PRDX1(1), PRDX2(2), PRDX6(2), TPO(30), TYR(5) 1941302 68 42 65 39 55 4 1 3 5 0 0.314 1.000 1.000 402 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(4), CARS(6), DARS(2), EPRS(6), FARS2(3), GARS(5), HARS(3), IARS(5), KARS(3), LARS(8), LARS2(3), MARS(5), MARS2(3), NARS(2), QARS(6), RARS(5), SARS(4), TARS(1), WARS(3), WARS2(1), YARS(1) 6484002 79 41 76 27 49 8 5 8 9 0 0.0375 1.000 1.000 403 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(8), ALDOC(1), DERA(1), FBP1(1), FBP2(1), G6PD(2), GPI(2), H6PD(4), PFKL(2), PGD(3), PGLS(1), PGM1(2), PGM3(1), PRPS1(1), PRPS1L1(8), PRPS2(1), RBKS(3), TALDO1(3), TKT(5), TKTL1(1), TKTL2(14) 4862631 66 41 65 55 42 8 3 4 9 0 0.900 1.000 1.000 404 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(8), CYP2A13(6), CYP2A6(9), CYP2A7(6), NAT1(1), NAT2(6), XDH(38) 1616225 74 41 73 46 63 1 5 2 3 0 0.120 1.000 1.000 405 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(3), GLB1(5), HEXA(5), HEXB(2), LCT(31), MAN2B1(6), MAN2B2(4), MAN2C1(1), MANBA(4), NEU1(4), NEU2(12), NEU3(2), NEU4(7) 4063940 86 41 85 50 69 7 1 8 1 0 0.472 1.000 1.000 406 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(2), CREBBP(14), EP300(8), FYN(5), IL2RG(2), IL7(3), IL7R(15), JAK1(4), JAK3(5), LCK(9), PIK3CA(2), PIK3R1(2), PTK2B(7), STAT5A(2), STAT5B(4) 5591345 84 41 83 45 56 11 4 7 6 0 0.599 1.000 1.000 407 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(17), ADRB2(1), GNAS(12), PLCE1(27), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4) 2917510 74 41 74 46 55 3 5 5 6 0 0.709 1.000 1.000 408 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(1), AKT2(6), AKT3(3), BCL2(2), GRB2(2), GSK3B(2), IL4R(7), IRS1(3), IRS2(1), JAK1(4), JAK3(5), MAP4K1(6), MAPK1(3), MAPK3(1), PDK1(1), PIK3CA(2), PIK3CD(2), PIK3R1(2), PPP1R13B(5), RAF1(2), SHC1(1), SOS1(6), SOS2(3), STAT6(5) 7310294 75 41 75 39 51 12 2 5 5 0 0.447 1.000 1.000 409 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(17), GNAS(12), PPP2CA(1), PRKAA1(1), PRKAA2(18), PRKAB2(1), PRKACB(2), PRKACG(7), PRKAG1(2), PRKAG2(3), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4) 3057631 72 40 71 42 55 4 3 3 7 0 0.641 1.000 1.000 410 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(7), GABRA1(8), GABRA2(10), GABRA3(14), GABRA4(6), GABRA5(2), GABRA6(17), GPHN(1), NSF(1), SRC(1), UBQLN1(4) 2345599 71 40 65 42 60 3 1 1 6 0 0.517 1.000 1.000 411 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(4), JUN(1), MAP2K1(7), MAP2K4(3), MAPK3(1), PDGFA(1), PDGFRA(15), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(8), RAF1(2), RASA1(1), SHC1(1), SOS1(6), SRF(1), STAT1(2), STAT3(6), STAT5A(2) 6978496 75 40 71 41 48 7 4 10 6 0 0.708 1.000 1.000 412 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM2(1), CAMK1(4), CAMK1G(9), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CAMK4(9), ESRRA(1), HDAC5(3), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), PPARA(4), PPP3CA(4), PPP3CB(1), PPP3CC(1), SLC2A4(6), SYT1(12) 4017272 75 40 75 48 57 5 2 7 4 0 0.652 1.000 1.000 413 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(1), PIK3CA(2), PIK3R1(2), PLCB1(33), PLCG1(4), PRKCA(8), VAV1(13) 2580439 63 40 59 32 54 2 0 4 3 0 0.384 1.000 1.000 414 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM2(1), CHUK(1), EGR2(4), EGR3(1), GNAQ(1), MYC(2), NFATC1(13), NFATC2(6), NFKB1(3), NFKBIA(2), PLCG1(4), PPP3CA(4), PPP3CB(1), PPP3CC(1), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), RELA(2), SYT1(12), VIP(3), VIPR2(4) 5583301 82 40 82 60 64 6 4 4 4 0 0.945 1.000 1.000 415 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(23), AGT(3), AGTR1(7), AGTR2(3), BDKRB2(2), KNG1(4), NOS3(13), REN(8) 1979996 63 39 60 46 45 4 1 6 7 0 0.597 1.000 1.000 416 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3D(5), CD3E(2), CD80(3), CD86(16), CTLA4(1), GRB2(2), HLA-DRA(7), HLA-DRB1(2), ICOS(2), IL2(4), ITK(19), LCK(9), PIK3CA(2), PIK3R1(2), PTPN11(5) 2564266 81 39 79 30 56 7 1 9 8 0 0.134 1.000 1.000 417 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(3), EPHA4(11), EPHB1(17), FYN(5), ITGA1(15), ITGB1(4), L1CAM(5), LYN(3), SELP(15) 3164032 78 39 74 44 56 4 1 10 7 0 0.579 1.000 1.000 418 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(12), G6PD(2), GCLC(4), GCLM(1), GGT1(4), GPX1(2), GPX3(2), GPX5(6), GSS(5), GSTA1(5), GSTA2(1), GSTA3(1), GSTM1(1), GSTM2(2), GSTM3(2), GSTM4(1), GSTM5(3), GSTT1(1), IDH1(7), MGST1(1), MGST2(1), PGD(3) 3623329 67 39 62 34 43 5 2 12 5 0 0.210 1.000 1.000 419 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(9), BCAT2(1), IARS(5), IARS2(10), ILVBL(2), LARS(8), LARS2(3), PDHA1(1), PDHA2(9), PDHB(1), VARS(14), VARS2(4) 3799230 67 39 63 23 46 8 1 6 6 0 0.0609 1.000 1.000 420 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 CAT(4), EPX(5), LPO(11), MPO(6), PRDX1(1), PRDX2(2), PRDX6(2), SHMT2(2), TPO(30) 2378086 63 39 60 36 52 4 1 3 3 0 0.201 1.000 1.000 421 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(2), CNR1(7), CNR2(1), DNMT1(13), MTNR1A(6), MTNR1B(5), PTAFR(1), PTGDR(7), PTGER2(5), PTGFR(13), PTGIR(3), TBXA2R(3) 2234610 66 39 62 50 46 6 3 4 7 0 0.425 1.000 1.000 422 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(16), HLA-DRA(7), HLA-DRB1(2), IFNG(2), IFNGR1(3), IFNGR2(2), IL12A(2), IL12B(3), IL12RB1(9), IL12RB2(3), IL18(2), IL18R1(14), IL2(4), IL2RA(4), IL4(1), IL4R(7) 2541661 81 39 80 31 63 5 0 5 8 0 0.0399 1.000 1.000 423 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(4), ALOX15(4), ALOX15B(5), ALOX5(8), ALOX5AP(1), DPEP1(3), GGT1(4), LTA4H(2), PLA2G2A(2), PLA2G6(7), PTGDS(2), PTGIS(9), PTGS1(14), PTGS2(6), TBXAS1(8) 2989502 79 38 78 44 56 6 2 9 6 0 0.126 1.000 1.000 424 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(7), POLR1B(5), POLR1C(1), POLR2A(10), POLR2B(11), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(2), POLR3B(12), POLR3GL(1), POLR3K(1) 4720224 57 38 57 23 33 8 4 8 4 0 0.208 1.000 1.000 425 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(1), IKBKB(2), IL1A(3), IL1R1(7), MAP3K14(1), MYD88(2), NFKB1(3), NFKBIA(2), RELA(2), RIPK1(1), TLR4(26), TNF(1), TNFAIP3(2), TNFRSF1A(2), TNFRSF1B(1), TRAF6(2) 4796893 58 38 55 40 42 3 2 5 6 0 0.879 1.000 1.000 426 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(23), CD44(5), CSF1(8), FCGR3A(5), IL1B(5), IL6R(2), SELL(6), SPN(5), TGFB2(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF8(11), TNFSF8(2) 2590590 77 38 75 31 61 5 2 2 7 0 0.0210 1.000 1.000 427 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(4), BIRC3(6), CASP3(1), CASP8(2), CFLAR(3), JUN(1), MAP2K4(3), MAP3K3(4), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NR2C2(2), RALBP1(2), RIPK1(1), TNF(1), TNFAIP3(2), TNFRSF1A(2), TNFRSF1B(1), TRAF2(2) 5421857 50 38 50 28 25 5 6 11 3 0 0.659 1.000 1.000 428 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(20), CD3D(5), CD3E(2), CD8A(2), ICAM1(2), ITGAL(17), ITGB2(10), PTPRC(18) 2125902 76 38 70 32 60 2 0 6 8 0 0.0262 1.000 1.000 429 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(12), CDH1(4), CREBBP(14), EP300(8), MAP2K1(7), MAPK3(1), SKIL(1), TGFB2(1), TGFB3(1), TGFBR2(5) 5163446 54 38 51 25 33 5 2 6 8 0 0.740 1.000 1.000 430 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(20), CD3D(5), CD3E(2), CD4(4), ICAM1(2), ITGAL(17), ITGB2(10), PTPRC(18) 2229038 78 38 72 38 60 3 0 7 8 0 0.0930 1.000 1.000 431 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(2), BAG4(1), CASP2(1), CASP3(1), CASP8(2), CRADD(1), DFFA(1), DFFB(2), JUN(1), LMNA(3), LMNB1(1), LMNB2(4), MADD(7), MAP2K4(3), PAK1(2), PAK2(2), PRKDC(13), RB1(3), RIPK1(1), SPTAN1(4), TNF(1), TNFRSF1A(2), TRAF2(2) 7824495 60 38 59 32 32 7 6 8 5 2 0.569 1.000 1.000 432 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(5), CHAT(11), COMT(2), DBH(5), DDC(7), GAD1(7), GAD2(4), HDC(8), MAOA(2), PAH(3), PNMT(4), SLC18A3(2), TH(7), TPH1(2) 2828560 70 37 70 56 55 6 2 2 5 0 0.808 1.000 1.000 433 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(8), ALDOC(1), FBP1(1), FBP2(1), GOT1(4), GOT2(2), GPT(3), MDH1(1), MDH2(2), ME1(14), ME2(1), ME3(6), PGK1(2), PKLR(6), PKM2(5), TKT(5) 3634375 63 37 62 32 44 5 4 5 5 0 0.127 1.000 1.000 434 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(2), ACO2(2), CS(1), DLD(1), FH(3), IDH1(7), IDH3A(3), IDH3G(2), MDH1(1), MDH2(2), PC(6), PCK1(20), SDHA(1), SUCLG1(1), SUCLG2(2) 4168676 54 37 48 30 40 1 5 5 3 0 0.425 1.000 1.000 435 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(4), B3GNT1(2), B3GNT2(2), B3GNT3(4), B3GNT4(2), B3GNT5(1), B4GALT1(1), B4GALT2(2), B4GALT3(2), FUT1(3), FUT2(2), FUT3(4), FUT4(1), FUT5(6), FUT6(1), FUT7(2), FUT9(14), ST3GAL6(2) 3197945 55 37 55 29 37 9 3 2 4 0 0.200 1.000 1.000 436 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(7), ASRGL1(1), CA1(8), CA12(3), CA13(5), CA2(5), CA3(3), CA4(1), CA5A(2), CA5B(1), CA6(3), CA7(1), CA8(4), CA9(5), CPS1(13), GLS(1), GLS2(3), GLUD1(1), GLUD2(1), HAL(8) 4221794 77 37 76 34 57 7 3 6 4 0 0.150 1.000 1.000 437 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(5), GBA(2), GBA3(6), LPO(11), MPO(6), PRDX6(2), TPO(30) 1685272 62 37 59 39 51 4 1 3 3 0 0.371 1.000 1.000 438 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(5), CD3D(5), CD3E(2), CXCR3(2), ETV5(4), IFNG(2), IL12A(2), IL12B(3), IL12RB1(9), IL12RB2(3), IL18(2), IL18R1(14), JAK2(6), JUN(1), MAP2K6(2), MAPK14(4), STAT4(13), TYK2(4) 3720369 83 37 83 46 64 6 2 7 4 0 0.571 1.000 1.000 439 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(16), CPT1A(7), LEP(1), LEPR(13), PRKAA1(1), PRKAA2(18), PRKAB2(1), PRKAG1(2), PRKAG2(3) 2936945 62 37 60 36 46 4 2 3 7 0 0.766 1.000 1.000 440 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(3), GLB1(5), HEXA(5), HEXB(2), LCT(31), MAN2C1(1), MANBA(4), NEU1(4), NEU2(12), NEU3(2), NEU4(7) 3297721 76 37 75 44 61 6 1 7 1 0 0.567 1.000 1.000 441 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(10), ATR(13), CDC25C(3), CHEK1(1), TP53(26) 3214053 53 37 49 19 30 1 4 6 12 0 0.412 1.000 1.000 442 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(1), AKT2(6), AKT3(3), GRB2(2), MAPK1(3), MAPK3(1), PDK1(1), PIK3CA(2), PIK3CD(2), PTEN(12), PTK2B(7), RBL2(2), SHC1(1), SOS1(6) 4115540 49 37 49 22 25 4 2 8 10 0 0.593 1.000 1.000 443 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(5), APOA1(2), APOA4(5), APOC1(1), CETP(4), CYP7A1(5), HMGCR(8), LDLR(10), LIPC(6), LPL(2), LRP1(22), SCARB1(4), SOAT1(3) 5559465 77 37 76 45 48 9 4 9 7 0 0.389 1.000 1.000 444 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(1), ALDOB(8), ALDOC(1), FBP1(1), FBP2(1), FPGT(2), GCK(10), GMDS(4), GMPPA(1), GMPPB(2), HK1(1), HK2(5), HK3(10), KHK(1), MPI(1), PFKFB1(2), PFKFB3(2), PFKFB4(4), SORD(1) 4773975 60 36 57 46 44 8 3 2 3 0 0.638 1.000 1.000 445 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(1), BCL2(2), BCR(6), FOS(1), GRB2(2), HRAS(1), JAK2(6), JUN(1), MAP2K1(7), MAP2K4(3), MAPK3(1), MYC(2), PIK3CA(2), PIK3R1(2), RAF1(2), SOS1(6), STAT1(2), STAT5A(2), STAT5B(4) 5600018 53 36 50 31 31 6 5 9 2 0 0.806 1.000 1.000 446 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 CAT(4), EPX(5), LPO(11), MPO(6), MTHFR(1), PRDX6(2), SHMT2(2), TPO(30) 2350046 61 36 58 38 51 4 1 3 2 0 0.315 1.000 1.000 447 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG5(2), ATG7(5), BECN1(1), GABARAPL1(1), IFNA10(2), IFNA14(6), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(3), IFNG(2), PIK3C3(1), PIK3R4(2), PRKAA1(1), PRKAA2(18), ULK1(4), ULK2(5), ULK3(1) 4187778 75 36 73 38 57 5 4 6 3 0 0.290 1.000 1.000 448 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), INSR(13), IRS1(3), JUN(1), MAP2K1(7), MAPK3(1), PIK3CA(2), PIK3R1(2), PTPN11(5), RAF1(2), RASA1(1), SHC1(1), SLC2A4(6), SOS1(6), SRF(1) 5131924 57 36 54 28 31 8 1 14 3 0 0.621 1.000 1.000 449 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(15), CD38(3), ENPP1(9), ENPP3(10), NADSYN1(2), NMNAT2(3), NNMT(8), NNT(3), NT5E(4), NT5M(1), QPRT(5) 2924629 63 36 60 33 44 7 3 4 5 0 0.466 1.000 1.000 450 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(7), CA1(8), CA12(3), CA2(5), CA3(3), CA4(1), CA5A(2), CA5B(1), CA6(3), CA7(1), CA8(4), CA9(5), CPS1(13), GLS(1), GLS2(3), GLUD1(1), HAL(8) 3773875 70 36 69 31 51 6 3 6 4 0 0.173 1.000 1.000 451 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(5), CD2(20), CD3D(5), CD3E(2), CD4(4), CXCR3(2), IFNG(2), IL12A(2), IL12B(3), IL12RB1(9), IL12RB2(3), JAK2(6), STAT4(13), TYK2(4) 2913066 80 36 77 47 59 7 2 7 5 0 0.520 1.000 1.000 452 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(1), FOS(1), GRB2(2), HRAS(1), JAK2(6), JUN(1), MAP2K1(7), MAPK3(1), MPL(2), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(8), RAF1(2), RASA1(1), SHC1(1), SOS1(6), STAT1(2), STAT3(6), STAT5A(2), STAT5B(4), THPO(4) 5985736 66 36 62 35 42 6 4 10 4 0 0.697 1.000 1.000 453 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(4), CREBBP(14), EP300(8), NCOA3(8), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), RARA(1), RXRA(1) 4159025 53 35 53 29 36 3 2 7 5 0 0.787 1.000 1.000 454 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(8), GABRA2(10), GABRA3(14), GABRA4(6), GABRA5(2), GABRA6(17), GPX1(2), PRKCE(4) 1543377 63 35 58 35 50 5 0 3 5 0 0.387 1.000 1.000 455 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), IGF1(7), IGF1R(6), IRS1(3), JUN(1), MAP2K1(7), MAPK3(1), PIK3CA(2), PIK3R1(2), PTPN11(5), RAF1(2), RASA1(1), SHC1(1), SOS1(6), SRF(1) 4959324 51 35 48 27 30 9 1 9 2 0 0.697 1.000 1.000 456 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(14), FOS(1), GRB2(2), HRAS(1), IL3(2), IL3RA(4), JAK2(6), MAP2K1(7), MAPK3(1), PTPN6(1), RAF1(2), SHC1(1), SOS1(6), STAT5A(2), STAT5B(4) 3519191 54 35 51 29 34 3 3 8 6 0 0.536 1.000 1.000 457 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(3), CALM2(1), CAPN2(2), CAPNS1(1), EP300(8), HDAC1(1), MEF2D(2), NFATC1(13), NFATC2(6), PPP3CA(4), PPP3CB(1), PPP3CC(1), PRKCA(8), SYT1(12) 4925562 63 35 62 35 48 5 4 3 3 0 0.579 1.000 1.000 458 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(13), AP2A1(1), BIN1(1), CALM2(1), DNM1(7), EPN1(5), EPS15(1), PICALM(1), PPP3CA(4), PPP3CB(1), PPP3CC(1), SYNJ1(11), SYNJ2(11), SYT1(12) 4280377 70 35 69 37 53 6 2 7 2 0 0.512 1.000 1.000 459 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(8), ALDOC(1), FBP1(1), FBP2(1), G6PD(2), GPI(2), H6PD(4), PGD(3), PGLS(1), PGM1(2), PGM3(1), PRPS1(1), PRPS1L1(8), PRPS2(1), RBKS(3), TAL1(5), TALDO1(3), TKT(5) 4097055 53 35 52 45 32 6 3 5 7 0 0.927 1.000 1.000 460 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(1), CCND1(1), CCNE1(3), CDK4(2), CDK6(1), CDKN1A(2), CDKN1B(1), E2F1(5), HRAS(1), MAPK1(3), MAPK3(1), NFKB1(3), NFKBIA(2), PAK1(2), PIK3CA(2), PIK3R1(2), RAC1(9), RAF1(2), RB1(3), RELA(2), TFDP1(1) 4034691 49 35 45 27 31 5 3 5 3 2 0.591 1.000 1.000 461 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(3), BIRC2(4), BIRC3(6), CASP10(4), CASP3(1), CASP7(4), CASP8(2), CASP9(3), DFFA(1), DFFB(2), GZMB(2), PRF1(6), SCAP(6), SREBF1(3), SREBF2(6) 3648080 53 35 52 24 33 5 6 6 3 0 0.232 1.000 1.000 462 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(3), ACTR2(2), ARPC1B(2), ARPC2(1), ARPC3(1), NCKAP1(2), NTRK1(10), RAC1(9), WASF1(1), WASF2(4), WASF3(11), WASL(3) 3071011 49 34 44 23 38 2 2 4 3 0 0.539 1.000 1.000 463 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(2), ACTN2(14), ACTN3(5), BCAR1(3), CSK(1), CTNNA1(2), CTNNA2(17), CTNNB1(6), PTK2(3), PXN(3), SRC(1), VCL(4) 3773226 61 34 61 42 40 2 1 10 7 1 0.749 1.000 1.000 464 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(1), MAP2K1(7), MAP2K2(2), MAP2K3(4), MAP2K6(2), MAPK1(3), MAPK14(4), MAPK3(1), NFKB1(3), PIK3CA(2), PIK3R1(2), RB1(3), RELA(2), SP1(4) 3869272 40 34 37 26 23 5 2 4 4 2 0.926 1.000 1.000 465 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(5), ASPH(3), COPS5(2), EDN1(7), EP300(8), EPO(4), HIF1A(1), JUN(1), LDHA(2), NOS3(13), P4HB(2), VHL(2) 3435435 50 34 48 22 36 3 3 4 4 0 0.380 1.000 1.000 466 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), B4GALNT1(1), GLB1(5), HEXA(5), HEXB(2), LCT(31), SLC33A1(4), ST3GAL1(5), ST3GAL5(2), ST6GALNAC3(4), ST6GALNAC5(5), ST6GALNAC6(2), ST8SIA5(5) 3308001 72 34 71 45 50 6 1 10 5 0 0.642 1.000 1.000 467 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(29), CYP2C9(28) 403785 57 34 53 36 49 3 2 0 3 0 0.524 1.000 1.000 468 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(14), EP300(8), LPL(2), NCOA1(8), NCOA2(12), PPARG(8), RXRA(1) 3740863 53 34 51 20 40 4 2 4 3 0 0.289 1.000 1.000 469 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(1), BCAR1(3), CDKN1B(1), GRB2(2), ITGB1(4), MAPK1(3), MAPK3(1), PDK2(4), PDPK1(3), PIK3CA(2), PIK3R1(2), PTEN(12), PTK2(3), SHC1(1), SOS1(6) 3832554 48 34 47 20 25 3 2 9 9 0 0.629 1.000 1.000 470 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(1), AKT1(1), ANXA1(3), CALM2(1), GNAS(12), NFKB1(3), NOS3(13), NPPA(1), NR3C1(2), PIK3CA(2), PIK3R1(2), RELA(2), SYT1(12) 3552645 55 33 54 42 45 4 2 3 1 0 0.968 1.000 1.000 471 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(3), ACOX1(3), ACOX3(5), ELOVL2(2), ELOVL6(2), FADS2(2), FASN(9), HADHA(7), HSD17B12(1), PECR(1), SCD(2) 2868169 37 33 37 22 24 4 1 4 4 0 0.365 1.000 1.000 472 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(3), CASP2(1), CHUK(1), CRADD(1), IKBKB(2), JUN(1), LTA(2), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP3K14(1), MAP4K2(4), MAPK14(4), NFKB1(3), NFKBIA(2), RELA(2), RIPK1(1), TNF(1), TNFRSF1A(2), TRAF2(2) 4762222 42 33 42 33 25 6 2 4 5 0 0.944 1.000 1.000 473 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(5), CD3E(2), CD4(4), FYN(5), HLA-DRA(7), HLA-DRB1(2), LCK(9), PTPRC(18), ZAP70(4) 1767728 56 33 53 28 41 6 0 6 3 0 0.320 1.000 1.000 474 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(5), CHUK(1), IFNG(2), IKBKB(2), IL2(4), IL4(1), JUN(1), MAP3K5(11), MAP4K5(3), MAPK14(4), NFKB1(3), NFKBIA(2), RELA(2), TNFRSF9(3), TNFSF9(1), TRAF2(2) 3833868 47 32 47 24 29 3 1 7 7 0 0.615 1.000 1.000 475 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(20), MAP2(7), PPP1CA(1), PPP2CA(1), PRKACB(2), PRKACG(7), PRKAG1(2), PRKAR2A(1), PRKAR2B(4), PRKCE(4) 3626999 49 32 49 26 30 5 1 6 7 0 0.797 1.000 1.000 476 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM2(1), CDKN1A(2), GNAQ(1), MARCKS(1), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), PLCG1(4), PPP3CA(4), PPP3CB(1), PPP3CC(1), PRKCA(8), SP1(4), SP3(1), SYT1(12) 4198103 70 32 69 35 52 9 3 2 4 0 0.421 1.000 1.000 477 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(16), ACACB(14), FASN(9), MCAT(1), OLAH(8), OXSM(1) 3171641 49 32 48 26 32 5 2 6 4 0 0.318 1.000 1.000 478 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(4), DHRS1(2), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(3), HEMK1(1), LCMT1(4), METTL2B(6), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(7), WBSCR22(1) 3031204 49 32 48 25 27 8 2 10 2 0 0.443 1.000 1.000 479 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), IL6R(2), IL6ST(6), JAK1(4), JAK2(6), JAK3(5), JUN(1), MAP2K1(7), MAPK3(1), PTPN11(5), RAF1(2), SHC1(1), SOS1(6), SRF(1), STAT3(6) 4762567 59 32 56 32 34 8 2 11 4 0 0.691 1.000 1.000 480 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(5), ACADS(2), ACADVL(1), ACSL1(3), ACSL3(3), CPT1A(7), CPT2(1), DCI(2), EHHADH(5), HADHA(7), PECR(1) 3412070 39 32 36 16 28 1 2 4 4 0 0.297 1.000 1.000 481 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(3), ATP6AP1(1), ATP6V0A1(5), ATP6V0A4(12), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C2(6), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), FDXR(7) 3223397 53 32 53 34 32 3 2 9 7 0 0.682 1.000 1.000 482 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), IL6R(2), JAK1(4), JAK2(6), JAK3(5), PIAS3(3), PTPRU(12), REG1A(5), SRC(1), STAT3(6) 3041327 46 32 46 29 29 4 2 6 5 0 0.626 1.000 1.000 483 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(3), ATP6AP1(1), ATP6V0A1(5), ATP6V0A4(12), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C2(6), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5) 3030024 46 31 46 31 27 3 2 8 6 0 0.767 1.000 1.000 484 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(3), ATP6AP1(1), ATP6V0A1(5), ATP6V0A4(12), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C2(6), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5) 3030024 46 31 46 31 27 3 2 8 6 0 0.767 1.000 1.000 485 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(8), IL13(2), IL4(1), IL5(4), MAF(1), MAP2K3(4), MAPK14(4), NFATC1(13), NFATC2(6), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4) 2414728 60 31 58 32 45 6 1 3 5 0 0.239 1.000 1.000 486 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(2), B3GAT2(2), B3GAT3(3), CHPF(3), CHST11(4), CHST12(1), CHST13(2), CHST14(2), CHSY1(5), DSE(9), XYLT1(8), XYLT2(2) 2658019 43 31 43 35 27 6 2 6 2 0 0.843 1.000 1.000 487 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(4), CSF1(8), CSF2(2), CSF3(2), HLA-DRA(7), HLA-DRB1(2), IFNB1(5), IFNG(2), IL10(2), IL11(2), IL12A(2), IL12B(3), IL13(2), IL15(1), IL1A(3), IL2(4), IL3(2), IL4(1), IL5(4), IL7(3), IL8(1), LTA(2), PDGFA(1), TGFB2(1), TGFB3(1), TNF(1) 2635610 68 31 67 37 49 6 1 4 8 0 0.0935 1.000 1.000 488 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(1), APC(12), AXIN1(6), BTRC(4), CTNNB1(6), DLL1(2), FZD1(1), GSK3B(2), NOTCH1(4), PSEN1(1), WNT1(1) 4221516 40 31 40 26 19 5 3 4 9 0 0.924 1.000 1.000 489 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(1), CASP9(3), CHUK(1), ELK1(1), H2AFX(1), HRAS(1), MAP2K1(7), MAPK3(1), NFKB1(3), PIK3CA(2), PIK3R1(2), RAC1(9), RAF1(2), RALBP1(2), RALGDS(3), RELA(2) 3780383 41 31 34 28 29 6 1 5 0 0 0.836 1.000 1.000 490 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(4), JAK2(6), JAK3(5), PIAS1(2), PIAS3(3), PTPRU(12), REG1A(5), SOAT1(3) 2735318 42 31 42 20 27 3 2 6 4 0 0.328 1.000 1.000 491 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(3), ATP6AP1(1), ATP6V0A1(5), ATP6V0A4(12), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C2(6), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5) 3030024 46 31 46 31 27 3 2 8 6 0 0.767 1.000 1.000 492 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM2(1), CAMK1(4), CAMK1G(9), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CAMK4(9), CAMKK1(1), CAMKK2(4), SYT1(12) 2331722 52 30 52 42 39 5 2 3 3 0 0.895 1.000 1.000 493 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(3), ARHGDIB(2), BIRC2(4), BIRC3(6), CASP1(3), CASP10(4), CASP2(1), CASP3(1), CASP4(1), CASP7(4), CASP8(2), CASP9(3), CYCS(1), DFFA(1), DFFB(2), GZMB(2), LMNA(3), LMNB1(1), LMNB2(4), PRF1(6) 3929288 54 30 54 21 32 8 5 7 2 0 0.152 1.000 1.000 494 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(10), CDC25A(6), CDC25B(3), CDC25C(3), CHEK1(1), MYT1(15), WEE1(2) 2768008 40 30 39 23 26 4 1 3 6 0 0.811 1.000 1.000 495 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), ELK1(1), EPO(4), EPOR(1), FOS(1), GRB2(2), HRAS(1), JAK2(6), JUN(1), MAP2K1(7), MAPK3(1), PLCG1(4), PTPN6(1), RAF1(2), SHC1(1), SOS1(6), STAT5A(2), STAT5B(4) 4269750 46 30 43 27 27 3 4 9 3 0 0.757 1.000 1.000 496 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(1), KHK(1), LCT(31), MPI(1), PGM1(2), PYGL(4), PYGM(7), TREH(3) 2644560 50 30 50 44 41 3 0 3 3 0 0.852 1.000 1.000 497 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(5), CYP11A1(9), CYP11B2(9), CYP17A1(5), HSD11B1(8), HSD3B1(4), HSD3B2(9) 1383260 49 30 47 37 37 3 0 4 5 0 0.355 1.000 1.000 498 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(3), ACOX3(5), FADS2(2), PLA2G12B(3), PLA2G2A(2), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(14), PLA2G4A(8), PLA2G6(7) 2033650 53 30 53 30 39 5 0 4 5 0 0.353 1.000 1.000 499 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(5), IL22(1), IL22RA1(6), IL22RA2(1), JAK1(4), JAK2(6), JAK3(5), SOCS3(2), STAT1(2), STAT3(6), STAT5A(2), STAT5B(4), TYK2(4) 3646259 48 30 48 33 28 4 7 7 2 0 0.818 1.000 1.000 500 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(1), CHRNG(1), MUSK(22), PIK3CA(2), PIK3R1(2), PTK2(3), PTK2B(7), RAPSN(1), SRC(1), TERT(4) 3255602 44 29 43 46 35 2 1 5 1 0 0.994 1.000 1.000 501 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 GALNS(2), GLB1(5), GUSB(3), HEXA(5), HEXB(2), IDS(5), IDUA(4), LCT(31), NAGLU(3) 2866670 60 29 59 34 45 5 0 6 4 0 0.508 1.000 1.000 502 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(1), ACOT11(5), DHRS1(2), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(3), EHHADH(5), GCDH(3), HADHA(7), MYST3(10), MYST4(11), NAT6(2), PNPLA3(1), SH3GLB1(2) 5249385 60 29 58 40 39 7 1 10 3 0 0.937 1.000 1.000 503 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), EHHADH(5), HADHA(7) 2433641 38 29 37 18 23 5 1 5 4 0 0.235 1.000 1.000 504 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(1), CAT(4), GH1(1), GHR(16), HRAS(1), IGF1(7), IGF1R(6), PIK3CA(2), PIK3R1(2), SHC1(1) 2658746 41 29 41 24 29 6 0 4 2 0 0.652 1.000 1.000 505 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), AP2A1(1), BTK(8), EEA1(2), GSK3B(2), LYN(3), PDPK1(3), PFKL(2), PLCG1(4), PRKCE(4), PRKCZ(1), RAC1(9), RPS6KB1(2), VAV2(3) 4947516 45 29 40 28 31 1 3 3 7 0 0.520 1.000 1.000 506 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(2), ARPC1B(2), ARPC2(1), ARPC3(1), PAK1(2), PDGFRA(15), PIK3CA(2), PIK3R1(2), RAC1(9), WASL(3) 2698825 39 28 35 18 30 1 2 3 3 0 0.527 1.000 1.000 507 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), BCL2(2), CASP8(2), CYCS(1), MAP2K1(7), MAP2K4(3), MAPK1(3), MAPK3(1), NFKB1(3), NSMAF(3), RAF1(2), RELA(2), RIPK1(1), SMPD1(1), TNFRSF1A(2), TRAF2(2) 4086149 36 28 33 24 26 4 2 4 0 0 0.822 1.000 1.000 508 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(17), FHL5(6), FSHB(2), FSHR(12), GNAS(12) 1894140 49 28 48 34 38 2 2 3 4 0 0.876 1.000 1.000 509 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(14), EGFR(16), ERBB3(2), NRG1(11) 2079039 43 28 43 29 34 1 1 4 3 0 0.930 1.000 1.000 510 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(4), CHPT1(1), HEMK1(1), LCMT1(4), METTL2B(6), PCYT1A(2), PCYT1B(3), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(7), WBSCR22(1) 2821699 42 28 41 17 23 6 4 6 3 0 0.202 1.000 1.000 511 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(11), AMT(1), ATIC(2), FTCD(1), GART(7), MTFMT(1), MTHFD1(7), MTHFD2(2), MTHFR(1), MTR(5), SHMT2(2), TYMS(1) 3810185 41 28 41 28 27 3 1 5 5 0 0.823 1.000 1.000 512 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(1), RPL10L(6), RPL11(1), RPL13A(1), RPL14(1), RPL18(3), RPL18A(1), RPL21(1), RPL26(1), RPL27(2), RPL27A(1), RPL3(1), RPL30(1), RPL35(1), RPL38(1), RPL3L(3), RPL7(2), RPS10(1), RPS11(1), RPS13(1), RPS2(1), RPS20(2), RPS24(1), RPS27(1), RPS29(1), RPS5(1), RPS6(1), RPS7(1), RPSA(1) 4529258 41 28 41 28 24 3 4 7 3 0 0.800 1.000 1.000 513 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(5), CLOCK(2), CRY1(3), CRY2(2), CSNK1D(1), CSNK1E(3), NPAS2(3), PER1(4), PER2(10), PER3(7) 3413954 40 28 40 26 29 4 1 3 3 0 0.829 1.000 1.000 514 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(1), GRB2(2), HRAS(1), IGF1R(6), IRS1(3), MAP2K1(7), MAPK1(3), MAPK3(1), PIK3CA(2), PIK3R1(2), RAF1(2), SHC1(1), SOS1(6) 3815801 37 28 34 20 24 6 1 5 1 0 0.628 1.000 1.000 515 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(20), CD34(2), CD3D(5), CD3E(2), CD4(4), CD58(1), CD8A(2), CSF3(2), IL3(2), IL8(1), KITLG(6) 1232828 47 28 44 25 35 1 1 6 4 0 0.301 1.000 1.000 516 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(1), B4GALT1(1), B4GALT2(2), B4GALT3(2), B4GALT5(2), DDOST(2), DPAGT1(2), DPM1(1), FUT8(5), MAN1A1(8), MAN1B1(2), MGAT1(1), MGAT3(9), MGAT4A(5), MGAT5(2), RPN2(2), ST6GAL1(4) 4011801 52 28 51 37 33 6 1 6 6 0 0.829 1.000 1.000 517 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(8), CYP2E1(8), NR1I3(7), PTGS1(14), PTGS2(6) 1085963 43 27 43 24 32 2 0 4 5 0 0.294 1.000 1.000 518 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(11), AOC2(5), AOC3(6), CES1(12), ESD(1) 1209395 35 27 35 20 32 1 2 0 0 0 0.322 1.000 1.000 519 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(4), ARFGAP3(1), ARFGEF2(7), CLTA(1), CLTB(1), COPA(4), GBF1(7), GPLD1(16) 3298214 41 27 41 28 28 3 0 7 3 0 0.882 1.000 1.000 520 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(1), JUN(1), MAPK3(1), OPRK1(15), POLR2A(10), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4) 2577158 45 27 45 35 36 1 2 3 3 0 0.882 1.000 1.000 521 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(2), EGF(14), EGFR(16), HGS(3), TF(5), TFRC(3) 2577258 43 27 43 29 32 1 3 3 4 0 0.898 1.000 1.000 522 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(2), B3GNT2(2), B3GNT7(3), B4GALT1(1), B4GALT2(2), B4GALT3(2), CHST1(7), CHST2(2), CHST4(8), CHST6(4), FUT8(5), ST3GAL1(5), ST3GAL4(1) 2499986 44 27 43 23 30 8 3 2 1 0 0.177 1.000 1.000 523 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(3), B3GALNT1(5), B3GALT5(1), FUT1(3), FUT2(2), FUT9(14), GBGT1(1), GLA(1), HEXA(5), HEXB(2), NAGA(2), ST3GAL1(5) 2153015 44 27 43 29 31 3 2 6 2 0 0.614 1.000 1.000 524 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(8), CD4(4), HLA-DRA(7), HLA-DRB1(2), IL1B(5), IL4(1), IL5(4), IL5RA(7) 1073777 39 27 38 25 32 1 0 3 3 0 0.375 1.000 1.000 525 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(11), AMT(1), ATIC(2), GART(7), MTHFD1(7), MTHFD2(2), MTHFR(1), MTR(5), SHMT2(2), TYMS(1) 3597680 39 27 39 27 25 3 1 5 5 0 0.836 1.000 1.000 526 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(1), IFNB1(5), JAK1(4), PTPRU(12), REG1A(5), STAT1(2), STAT2(6), TYK2(4) 2514978 39 27 39 21 23 2 2 6 6 0 0.400 1.000 1.000 527 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(5), F13B(16), HSD17B2(7), HSD17B3(5), HSD17B4(3), HSD3B1(4), HSD3B2(9) 1602698 49 27 47 24 35 2 4 3 4 1 0.227 1.000 1.000 528 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(3), ARG1(1), ARG2(1), ASL(3), CKM(2), CKMT1A(1), CKMT2(5), CPS1(13), GAMT(3), GATM(2), GLUD1(1), OAT(1), ODC1(2), OTC(2), SMS(1) 3457107 41 27 40 22 26 5 3 3 4 0 0.432 1.000 1.000 529 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(12), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(8) 1894203 39 26 38 25 32 1 1 2 3 0 0.804 1.000 1.000 530 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(1), CASP9(3), CHUK(1), GH1(1), GHR(16), NFKB1(3), NFKBIA(2), PDPK1(3), PIK3CA(2), PIK3R1(2), PPP2CA(1), RELA(2) 2800030 37 26 36 28 26 4 3 1 3 0 0.948 1.000 1.000 531 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 GCK(10), GFPT1(1), GNE(3), HEXA(5), HEXB(2), HK1(1), HK2(5), HK3(10), PGM3(1), RENBP(2), UAP1(1) 3407507 41 26 39 28 30 3 1 4 3 0 0.773 1.000 1.000 532 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(1), GRB2(2), HRAS(1), MAPK1(3), MAPK3(1), MAPK7(2), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), NTRK1(10), PIK3CA(2), PIK3R1(2), PLCG1(4), RPS6KA1(4), SHC1(1) 3786398 41 26 41 33 31 5 1 3 1 0 0.934 1.000 1.000 533 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP51A1(1), DHCR24(1), DHCR7(6), FDPS(3), GGCX(3), GGPS1(1), HMGCR(8), LSS(2), MVD(1), MVK(2), NQO1(1), NSDHL(3), PMVK(1), SC4MOL(3), SC5DL(1), SQLE(2) 3869872 39 26 38 20 20 8 2 6 3 0 0.416 1.000 1.000 534 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(1), KLK2(1), MAP2K1(7), MAPK3(1), NGFR(6), PIK3CA(2), PIK3R1(2), PLCG1(4), RAF1(2), SHC1(1), SOS1(6) 3811003 39 26 36 24 27 5 0 5 2 0 0.816 1.000 1.000 535 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(14), EP300(8), ESR1(2), MAPK1(3), MAPK3(1), PELP1(9), SRC(1) 2940849 38 26 38 18 29 3 2 2 2 0 0.470 1.000 1.000 536 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(1), CCL2(1), CCR5(5), CXCL12(1), CXCR4(1), FOS(1), GNAQ(1), JUN(1), MAPK14(4), PLCG1(4), PRKCA(8), PTK2B(7), SYT1(12) 2781582 47 25 46 42 32 4 2 5 4 0 0.963 1.000 1.000 537 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(3), HS3ST1(8), HS3ST2(6), HS3ST3B1(2), XYLT1(8), XYLT2(2) 1274742 29 25 29 26 19 4 0 3 3 0 0.829 1.000 1.000 538 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(3), HS3ST1(8), HS3ST2(6), HS3ST3B1(2), XYLT1(8), XYLT2(2) 1274742 29 25 29 26 19 4 0 3 3 0 0.829 1.000 1.000 539 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(4), CAMK1G(9), HDAC9(27), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2) 1482576 48 25 44 24 38 5 0 3 2 0 0.344 1.000 1.000 540 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(4), IFNAR1(1), IFNAR2(5), IFNB1(5), NFKB1(3), RELA(2), TNFRSF11A(5), TNFSF11(4), TRAF6(2) 2222303 32 25 31 21 24 2 0 2 4 0 0.840 1.000 1.000 541 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(1), CREBBP(14), EP300(8), HDAC3(3), IKBKB(2), NFKB1(3), NFKBIA(2), RELA(2), RIPK1(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF6(2) 4479494 42 25 42 23 27 5 4 2 4 0 0.662 1.000 1.000 542 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), MAP3K14(1), MAPK14(4), NFKB1(3), RELA(2), TNFRSF13B(7), TNFRSF17(4), TRAF2(2), TRAF3(3), TRAF5(5), TRAF6(2) 2880747 34 25 34 21 25 3 0 4 2 0 0.745 1.000 1.000 543 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(15), GNA12(2), PRKACB(2), PRKACG(7), PRKAG1(2), PRKAR2A(1), PRKAR2B(4) 2027057 33 24 33 18 27 2 0 2 2 0 0.532 1.000 1.000 544 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(3), EGR1(1), HRAS(1), KLK2(1), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK3(1), NGFR(6), RAF1(2) 1624053 27 24 24 16 17 2 1 4 3 0 0.481 1.000 1.000 545 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(5), CDKN1A(2), EPO(4), EPOR(1), GRIN1(6), HIF1A(1), JAK2(6), NFKB1(3), NFKBIA(2), RELA(2) 2511853 32 24 32 18 15 4 4 3 6 0 0.713 1.000 1.000 546 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(3), FUT1(3), FUT2(2), FUT9(14), GBGT1(1), GLA(1), HEXA(5), HEXB(2), NAGA(2), ST3GAL1(5), ST3GAL4(1) 2026877 39 24 38 22 28 3 0 6 2 0 0.363 1.000 1.000 547 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(4), CHST12(1), CHST13(2), PAPSS1(2), PAPSS2(4), SULT1A1(9), SULT1A2(2), SULT1E1(10), SULT2A1(4), SULT2B1(6), SUOX(3) 1824417 47 24 46 26 38 2 0 3 4 0 0.366 1.000 1.000 548 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), GRB2(2), IL2RG(2), IL4(1), IL4R(7), IRS1(3), JAK1(4), JAK3(5), RPS6KB1(2), SHC1(1), STAT6(5) 2957759 33 24 33 18 20 4 3 2 4 0 0.533 1.000 1.000 549 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(3), ARHGAP5(9), ARHGDIB(2), CASP1(3), CASP10(4), CASP3(1), CASP8(2), CASP9(3), CYCS(1), GZMB(2), JUN(1), PRF1(6) 2600944 37 23 37 19 26 4 2 4 1 0 0.563 1.000 1.000 550 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(4), ANKRD1(1), CYR61(1), DUSP14(1), IFNG(2), IL18(2), IL1A(3), IL1R1(7), MYOG(3), NR4A3(5), WDR1(2) 2129584 31 23 29 17 20 3 0 2 6 0 0.640 1.000 1.000 551 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), BLVRB(1), HMOX1(1), IL10(2), IL10RA(5), IL10RB(4), IL1A(3), JAK1(4), STAT1(2), STAT3(6), STAT5A(2), TNF(1) 2453531 32 23 32 17 17 3 4 3 5 0 0.371 1.000 1.000 552 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(5), GAD1(7), HDC(8), PNMT(4), TH(7), TPH1(2) 1195550 33 23 33 21 28 1 1 1 2 0 0.377 1.000 1.000 553 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(3), CREBBP(14), DFFA(1), DFFB(2), GZMA(10), GZMB(2), PRF1(6), SET(2) 2133167 40 23 39 16 24 3 5 3 5 0 0.315 1.000 1.000 554 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(4), CD8A(2), CSF1(8), CSF2(2), CSF3(2), EPO(4), IL11(2), IL2(4), IL3(2), IL4(1), IL5(4), IL7(3), IL8(1) 1213035 39 23 38 26 29 3 0 3 4 0 0.405 1.000 1.000 555 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(1), IKBKAP(4), IKBKB(2), LTA(2), MAP3K14(1), NFKB1(3), NFKBIA(2), RELA(2), RIPK1(1), TNFAIP3(2), TNFRSF1B(1), TRAF1(6), TRAF2(2), TRAF3(3) 4470432 32 23 32 35 23 2 1 2 4 0 0.998 1.000 1.000 556 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(1), CD36(3), FOS(1), FYN(5), JUN(1), MAPK14(4), THBS1(19) 1488622 34 23 34 20 20 1 2 6 5 0 0.769 1.000 1.000 557 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(4), B3GNT1(2), FUT1(3), FUT2(2), FUT9(14) 1198591 25 22 25 14 19 3 1 2 0 0 0.355 1.000 1.000 558 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(5), DHRS1(2), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(3), HSD3B7(1), PON1(12), PON2(1), PON3(4), RDH12(1), RDH13(3) 1818107 40 22 38 24 30 2 0 5 3 0 0.431 1.000 1.000 559 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(10), MBTPS1(3), SCAP(6), SREBF1(3), SREBF2(6) 2374923 29 22 28 19 20 2 2 2 3 0 0.688 1.000 1.000 560 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(3), IL13RA2(2), IL4R(7), JAK1(4), JAK2(6), TYK2(4) 2097085 28 22 28 14 19 1 2 4 2 0 0.498 1.000 1.000 561 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(3), IL13RA2(2), IL4R(7), JAK1(4), JAK2(6), TYK2(4) 2097085 28 22 28 14 19 1 2 4 2 0 0.498 1.000 1.000 562 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(1), GRB2(2), HRAS(1), KLK2(1), NTRK1(10), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(8), SHC1(1), SOS1(6) 3114639 38 22 37 23 27 5 1 3 2 0 0.758 1.000 1.000 563 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(17), GNAS(12), PRKACA(2), PRKAR1A(1) 1300906 32 21 32 15 21 2 2 3 4 0 0.299 1.000 1.000 564 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(6), CDO1(3), CSAD(3), GAD1(7), GAD2(4), GGT1(4) 1134318 27 21 26 17 19 2 1 4 1 0 0.600 1.000 1.000 565 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(4), B3GALT1(10), B3GALT2(1), B3GALT5(1), B3GNT5(1), FUT1(3), FUT2(2), FUT3(4), ST3GAL4(1) 1441134 27 21 27 24 21 2 0 2 2 0 0.885 1.000 1.000 566 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(2), ACO2(2), AFMID(1), CS(1), HAO1(5), HAO2(7), HYI(1), MDH1(1), MDH2(2), MTHFD1(7), MTHFD2(2) 2692199 31 21 30 21 20 1 4 3 3 0 0.722 1.000 1.000 567 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 SEC22B(4), SNAP25(5), STX11(1), STX16(2), STX17(1), STX19(1), STX2(1), STX5(2), STX6(1), TSNARE1(2), VAMP3(1), VAMP4(1), VAMP7(2), VAMP8(1), VTI1A(1), VTI1B(1) 3318206 27 21 26 16 17 2 0 4 4 0 0.578 1.000 1.000 568 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(5), ADORA2A(2), ADORA2B(1), ADORA3(10), P2RY1(2), P2RY2(5), P2RY6(1) 1198176 26 21 26 24 17 5 0 2 2 0 0.500 1.000 1.000 569 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(5), CAPN1(1), CAPNS1(1), CDK5(3), CSNK1A1(2), CSNK1D(1), GSK3B(2), MAPT(7), PPP2CA(1) 1803693 23 21 23 12 14 1 1 2 5 0 0.545 1.000 1.000 570 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(12), CKM(2), GPT(3), LDHA(2), LDHC(3), MAPK14(4), NCL(4) 1805525 30 21 30 14 21 2 3 3 1 0 0.335 1.000 1.000 571 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(3), NRF1(4), UBE2D3(3), UBE2E1(1), UBE2I(2), UBE2J1(1), UBE2J2(3), UBE2L6(1), UBE2M(1), UBE2S(2), UBE3A(5) 2127504 26 21 25 11 19 5 0 2 0 0 0.368 1.000 1.000 572 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(6), FDPS(3), HMGCR(8), LSS(2), MVD(1), MVK(2), NQO1(1), PMVK(1), SC5DL(1), SQLE(2) 2211559 27 20 26 11 13 6 0 6 2 0 0.296 1.000 1.000 573 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(2), ACO2(2), CS(1), HAO1(5), HAO2(7), HYI(1), MDH1(1), MDH2(2), MTHFD1(7), MTHFD2(2) 2570721 30 20 29 17 20 1 3 3 3 0 0.508 1.000 1.000 574 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(10), HK1(1), HK2(5), HK3(10), IMPA1(1), IMPA2(2), ISYNA1(1), PGM1(2), PGM3(1), TGDS(1) 2337507 34 20 33 25 25 3 0 2 4 0 0.746 1.000 1.000 575 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(2), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(3), MYST3(10), MYST4(11), NAT6(2), PNPLA3(1), SH3GLB1(2) 3352608 39 20 38 31 25 5 1 6 2 0 0.989 1.000 1.000 576 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(3), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(1), PSMB4(1), PSMB5(1), PSMB7(1), PSMC3(2), PSMD14(1), RPN2(2), UBE3A(5) 2615652 25 20 25 11 15 4 1 3 2 0 0.464 1.000 1.000 577 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2) 1595261 26 19 26 14 15 4 1 2 4 0 0.357 1.000 1.000 578 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2) 1595261 26 19 26 14 15 4 1 2 4 0 0.357 1.000 1.000 579 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), IKBKAP(4), IKBKB(2), MAP3K14(1), NFKB1(3), NFKBIA(2), RELA(2), TNFAIP3(2), TRAF3(3), TRAF6(2) 3620731 22 19 22 24 15 2 1 2 2 0 0.995 1.000 1.000 580 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(1), IFNAR2(5), IFNB1(5), JAK1(4), STAT1(2), STAT2(6), TYK2(4) 2163961 27 19 27 16 17 1 2 4 3 0 0.652 1.000 1.000 581 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(1), ESR1(2), GREB1(15), HSPB1(2), HSPB2(1), MTA1(1), MTA3(1), PDZK1(2), TUBA8(1) 2136360 27 19 26 16 18 2 2 3 2 0 0.497 1.000 1.000 582 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(6), CDC25B(3), CDC25C(3), CSK(1), GRB2(2), PRKCA(8), PTPRA(3), SRC(1) 1868520 27 18 26 17 18 5 1 1 2 0 0.665 1.000 1.000 583 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(10), HK1(1), HK2(5), HK3(10), IMPA1(1), PGM1(2), PGM3(1), TGDS(1) 2054995 31 18 30 21 24 3 0 1 3 0 0.652 1.000 1.000 584 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(4), CD80(3), HLA-DRA(7), HLA-DRB1(2), IL10(2), IL2(4), IL4(1) 791800 23 17 23 15 14 1 1 5 2 0 0.606 1.000 1.000 585 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(8), ENO1(2), GPI(2), HK1(1), PFKL(2), PGK1(2), PKLR(6) 1841319 23 17 22 14 17 1 1 1 3 0 0.317 1.000 1.000 586 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP2(3), MMP9(5), RECK(4), TIMP2(1), TIMP3(4), TIMP4(4) 1492444 22 17 22 11 12 1 2 6 1 0 0.557 1.000 1.000 587 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(4), JAK2(6), JAK3(5), MAPK1(3), MAPK3(1), STAT3(6), TYK2(4) 2329397 29 17 29 25 18 3 3 3 2 0 0.931 1.000 1.000 588 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(6), ACO1(2), ACO2(2), ACSS2(3), FH(3), IDH1(7), MDH1(1), MDH2(2) 2692827 26 16 21 16 19 0 2 3 2 0 0.584 1.000 1.000 589 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(7), GOT1(4), GOT2(2), TAT(12), TYR(5) 946951 30 16 30 17 24 2 2 1 1 0 0.512 1.000 1.000 590 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(5), PLCG1(4), PRKCA(8), PTK2B(7) 1361174 24 16 23 18 20 2 0 0 2 0 0.619 1.000 1.000 591 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(2), B4GALT1(1), B4GALT2(2), B4GALT3(2), B4GALT5(2), FUT8(5), ST3GAL1(5), ST3GAL4(1) 1578521 20 16 20 13 11 4 2 2 1 0 0.714 1.000 1.000 592 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 FOS(1), JUN(1), KEAP1(1), MAPK1(3), MAPK14(4), NFE2L2(1), PRKCA(8) 1779493 19 15 18 12 12 1 0 3 3 0 0.797 1.000 1.000 593 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(4), FUT1(3), FUT2(2), FUT3(4), FUT5(6), FUT6(1) 1003570 20 15 20 17 14 2 1 0 3 0 0.676 1.000 1.000 594 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(5), CLOCK(2), CRY1(3), CRY2(2), CSNK1E(3), PER1(4) 1692490 19 15 19 10 14 1 1 2 1 0 0.678 1.000 1.000 595 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(7), EIF2AK4(7), EIF2B5(1), EIF2S1(1), GSK3B(2), PPP1CA(1) 2343282 19 15 18 11 13 0 0 4 2 0 0.830 1.000 1.000 596 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(1), BDH1(4), HMGCL(2), HMGCS1(1), HMGCS2(14), OXCT1(3), OXCT2(2) 1434917 27 15 26 14 19 3 0 3 2 0 0.587 1.000 1.000 597 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(2), CS(1), FH(3), MDH1(1), OGDH(8), SDHA(1) 1906980 16 15 15 11 11 0 2 0 3 0 0.827 1.000 1.000 598 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), CSF1(8), IL1B(5), MST1(1), MST1R(5), TNF(1) 1316298 21 15 21 13 16 2 1 0 2 0 0.555 1.000 1.000 599 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(6), ADSS(1), MTHFD2(2), POLD1(3), POLG(4), PRPS2(1), RRM1(3) 2488954 20 15 20 14 11 2 1 3 3 0 0.788 1.000 1.000 600 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2), MIOX(3) 1699457 20 14 20 15 12 3 2 0 3 0 0.736 1.000 1.000 601 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(2), ACO2(2), FH(3), IDH1(7), MDH1(1), MDH2(2) 1807183 17 14 12 10 12 0 2 2 1 0 0.623 1.000 1.000 602 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 11 ALAD(3), ALAS2(2), CPO(1), FECH(2), GATA1(1), HBB(5), HMBS(1), UROS(1) 1529810 16 13 15 10 13 1 0 0 2 0 0.525 1.000 1.000 603 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(2), HRAS(1), PTK2B(7), SHC1(1), SOS1(6), SRC(1) 1766438 18 13 18 13 14 1 0 2 1 0 0.873 1.000 1.000 604 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(4), HGD(11) 452460 15 13 15 14 11 2 2 0 0 0 0.905 1.000 1.000 605 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(4), APOBEC1(3), APOBEC2(3), APOBEC3A(1), APOBEC3B(1), APOBEC3C(2), APOBEC3F(1), APOBEC3G(1) 1487838 16 13 16 12 11 2 3 0 0 0 0.797 1.000 1.000 606 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(1), CSF1(8), LDLR(10), LPL(2) 1078788 21 13 21 14 17 3 1 0 0 0 0.593 1.000 1.000 607 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(4), HLA-DRA(7), HLA-DRB1(2) 473808 13 12 13 12 10 1 0 2 0 0 0.837 1.000 1.000 608 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(15), PSAT1(1) 978234 16 12 15 15 15 1 0 0 0 0 0.917 1.000 1.000 609 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(5), EPHX2(4), HSD3B7(1), RDH12(1), RDH13(3) 969697 14 11 14 11 11 0 1 0 2 0 0.666 1.000 1.000 610 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(1), COQ3(2), COQ6(1), NDUFA12(1), NDUFA13(5) 799349 10 10 9 10 7 1 2 0 0 0 0.963 1.000 1.000 611 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(1), DLL1(2), FURIN(2), NOTCH1(4), PSEN1(1) 1843128 10 10 10 13 6 2 1 1 0 0 0.971 1.000 1.000 612 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(5), CD3D(5), CD3E(2), CD4(4) 645504 16 10 16 19 11 2 0 2 1 0 0.960 1.000 1.000 613 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(3), AASDHPPT(1), AASS(1), KARS(3) 933736 8 8 8 5 7 0 0 1 0 0 0.807 1.000 1.000 614 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(5), ARG1(1), GLS(1), GLUD1(1), OAT(1), PRODH(1) 1089367 10 7 10 12 3 4 2 1 0 0 0.986 1.000 1.000 615 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(13) 367570 13 6 13 8 11 1 1 0 0 0 0.590 1.000 1.000 616 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2) 427553 2 2 2 4 1 0 0 1 0 0 0.984 1.000 1.000