Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.049 0.195 -9999.0 0.0 -0.556 15.0 15.0 IHH -0.005 0.059 -9999.0 0.0 -0.23 5.0 5.0 SHH Np/Cholesterol/GAS1 0.002 0.056 -9999.0 0.0 -0.237 6.0 6.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.002 0.056 0.236 6.0 -9999.0 0.0 6.0 SMO/beta Arrestin2 -0.036 0.155 -9999.0 0.0 -0.421 14.0 14.0 SMO -0.045 0.162 -9999.0 0.0 -0.447 14.0 14.0 AKT1 -0.006 0.081 -9999.0 0.0 -0.243 5.0 5.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.01 0.089 -9999.0 0.0 -0.328 10.0 10.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.044 0.16 -9999.0 0.0 -0.44 14.0 14.0 STIL -0.018 0.114 -9999.0 0.0 -0.305 14.0 14.0 DHH N/PTCH2 -0.026 0.099 -9999.0 0.0 -0.22 28.0 28.0 DHH N/PTCH1 -0.045 0.151 -9999.0 0.0 -0.358 19.0 19.0 PIK3CA 0.011 0.036 -9999.0 0.0 -0.419 1.0 1.0 DHH -0.043 0.128 -9999.0 0.0 -0.315 25.0 25.0 PTHLH -0.065 0.25 -9999.0 0.0 -0.759 14.0 14.0 determination of left/right symmetry -0.044 0.16 -9999.0 0.0 -0.44 14.0 14.0 PIK3R1 0.011 0.036 -9999.0 0.0 -0.419 1.0 1.0 skeletal system development -0.064 0.248 -9999.0 0.0 -0.75 14.0 14.0 IHH N/Hhip -0.002 0.058 -9999.0 0.0 -0.226 7.0 7.0 DHH N/Hhip -0.031 0.098 -9999.0 0.0 -0.214 30.0 30.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.044 0.16 -9999.0 0.0 -0.44 14.0 14.0 pancreas development -0.004 0.059 -9999.0 0.0 -0.266 7.0 7.0 HHAT 0.005 0.062 -9999.0 0.0 -0.419 3.0 3.0 PI3K 0.016 0.036 -9999.0 0.0 -0.288 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.005 0.062 -9999.0 0.0 -0.419 3.0 3.0 somite specification -0.044 0.16 -9999.0 0.0 -0.44 14.0 14.0 SHH Np/Cholesterol/PTCH1 -0.022 0.119 -9999.0 0.0 -0.31 16.0 16.0 SHH Np/Cholesterol/PTCH2 0.001 0.051 -9999.0 0.0 -0.217 4.0 4.0 SHH Np/Cholesterol/Megalin -0.087 0.106 -9999.0 0.0 -0.238 33.0 33.0 SHH -0.003 0.056 -9999.0 0.0 -0.212 9.0 9.0 catabolic process -0.026 0.139 -9999.0 0.0 -0.395 14.0 14.0 SMO/Vitamin D3 -0.031 0.137 -9999.0 0.0 -0.377 15.0 15.0 SHH Np/Cholesterol/Hhip -0.003 0.056 -9999.0 0.0 -0.256 4.0 4.0 LRP2 -0.166 0.179 -9999.0 0.0 -0.329 76.0 76.0 receptor-mediated endocytosis -0.089 0.161 -9999.0 0.0 -0.391 23.0 23.0 SHH Np/Cholesterol/BOC -0.006 0.061 -9999.0 0.0 -0.217 7.0 7.0 SHH Np/Cholesterol/CDO 0.003 0.056 -9999.0 0.0 -0.27 4.0 4.0 mesenchymal cell differentiation 0.003 0.055 0.255 4.0 -9999.0 0.0 4.0 mol:Vitamin D3 -0.02 0.12 -9999.0 0.0 -0.311 16.0 16.0 IHH N/PTCH2 0.003 0.059 -9999.0 0.0 -0.272 5.0 5.0 CDON 0.008 0.05 -9999.0 0.0 -0.419 2.0 2.0 IHH N/PTCH1 -0.024 0.141 -9999.0 0.0 -0.398 14.0 14.0 Megalin/LRPAP1 -0.105 0.126 -9999.0 0.0 -0.219 76.0 76.0 PTCH2 0.003 0.058 -9999.0 0.0 -0.297 5.0 5.0 SHH Np/Cholesterol -0.0 0.042 -9999.0 0.0 -0.223 3.0 3.0 PTCH1 -0.026 0.14 -9999.0 0.0 -0.397 14.0 14.0 HHIP -0.004 0.059 -9999.0 0.0 -0.267 7.0 7.0