Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.046 0.103 -9999.0 0.0 -0.197 45.0 45.0 epithelial cell differentiation -0.045 0.102 -9999.0 0.0 -0.192 45.0 45.0 CYFIP2 -0.007 0.093 -9999.0 0.0 -0.419 7.0 7.0 ENAH -0.016 0.079 -9999.0 0.0 -0.218 4.0 4.0 EGFR -0.015 0.092 -9999.0 0.0 -0.302 13.0 13.0 EPHA2 -0.007 0.087 -9999.0 0.0 -0.362 8.0 8.0 MYO6 -0.047 0.105 -9999.0 0.0 -0.189 48.0 48.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.013 0.06 -9999.0 0.0 -0.235 8.0 8.0 AQP5 -0.042 0.089 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.04 0.094 -9999.0 0.0 -0.176 45.0 45.0 regulation of calcium-dependent cell-cell adhesion -0.053 0.104 -9999.0 0.0 -0.19 48.0 48.0 EGF -0.092 0.176 -9999.0 0.0 -0.376 39.0 39.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.054 0.14 -9999.0 0.0 -0.455 10.0 10.0 cortical microtubule organization -0.045 0.102 -9999.0 0.0 -0.192 45.0 45.0 GO:0000145 -0.039 0.089 -9999.0 0.0 -0.168 45.0 45.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.043 0.104 -9999.0 0.0 -0.193 45.0 45.0 MLLT4 0.006 0.055 -9999.0 0.0 -0.368 3.0 3.0 ARF6/GDP -0.053 0.071 -9999.0 0.0 -0.268 3.0 3.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.024 0.048 -9999.0 0.0 -0.206 5.0 5.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.033 0.091 -9999.0 0.0 -0.211 1.0 1.0 PVRL2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.041 0.097 -9999.0 0.0 -0.181 45.0 45.0 ARF6/GTP 0.028 0.045 -9999.0 0.0 -0.186 5.0 5.0 CDH1 -0.132 0.2 -9999.0 0.0 -0.401 51.0 51.0 EGFR/EGFR/EGF/EGF -0.109 0.127 -9999.0 0.0 -0.231 63.0 63.0 RhoA/GDP -0.039 0.095 -9999.0 0.0 -0.177 45.0 45.0 actin cytoskeleton organization -0.043 0.102 -9999.0 0.0 -0.182 46.0 46.0 IGF-1R heterotetramer 0.009 0.042 -9999.0 0.0 -0.342 2.0 2.0 GIT1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.009 0.043 -9999.0 0.0 -0.343 2.0 2.0 IGF1 -0.034 0.132 -9999.0 0.0 -0.392 17.0 17.0 DIAPH1 -0.025 0.132 -9999.0 0.0 -0.567 8.0 8.0 Wnt receptor signaling pathway 0.045 0.102 0.192 45.0 -9999.0 0.0 45.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.054 0.072 -9999.0 0.0 -0.268 3.0 3.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.044 0.104 -9999.0 0.0 -0.186 46.0 46.0 EFNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.039 0.092 -9999.0 0.0 -0.166 48.0 48.0 Ephrin A1/EPHA2 -0.064 0.085 -9999.0 0.0 -0.176 49.0 49.0 SEC6/SEC8 -0.052 0.069 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.054 0.106 -9999.0 0.0 -0.192 48.0 48.0 HGF/MET -0.094 0.11 -9999.0 0.0 -0.308 18.0 18.0 HGF -0.029 0.115 -9999.0 0.0 -0.326 18.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.047 0.103 -9999.0 0.0 -0.199 45.0 45.0 actin cable formation -0.007 0.08 -9999.0 0.0 -0.239 3.0 3.0 KIAA1543 -0.07 0.112 -9999.0 0.0 -0.194 54.0 54.0 KIFC3 -0.042 0.096 -9999.0 0.0 -0.178 46.0 46.0 NCK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.045 0.097 -9999.0 0.0 -0.178 48.0 48.0 NCK1/GIT1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.045 0.102 -9999.0 0.0 -0.192 45.0 45.0 EXOC4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.04 0.096 -9999.0 0.0 -0.178 45.0 45.0 PIP5K1C -0.04 0.096 -9999.0 0.0 -0.178 45.0 45.0 LIMA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.011 0.036 -9999.0 0.0 -0.419 1.0 1.0 ROCK1 -0.022 0.085 -9999.0 0.0 -0.236 3.0 3.0 adherens junction assembly -0.055 0.109 -9999.0 0.0 -0.287 10.0 10.0 IGF-1R heterotetramer/IGF1 -0.077 0.101 -9999.0 0.0 -0.196 53.0 53.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.015 0.039 -9999.0 0.0 -0.249 3.0 3.0 MET -0.042 0.137 -9999.0 0.0 -0.368 21.0 21.0 PLEKHA7 -0.049 0.107 -9999.0 0.0 -0.192 48.0 48.0 mol:GTP 0.023 0.048 -9999.0 0.0 -0.205 5.0 5.0 establishment of epithelial cell apical/basal polarity -0.021 0.087 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.046 0.103 -9999.0 0.0 -0.197 45.0 45.0 regulation of cell-cell adhesion -0.043 0.102 -9999.0 0.0 -0.182 46.0 46.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.047 0.103 -9999.0 0.0 -0.199 45.0 45.0