Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	37.0	301.0	8.0	-0.124	0.081	1000.0	-1000.0	-0.006	-1000.0
E-cadherin signaling events	29.0	149.0	5.0	-0.132	0.014	1000.0	-1000.0	-0.003	-1000.0
Ephrin A  reverse signaling	27.0	194.0	7.0	-0.075	0.0	1000.0	-1000.0	-0.008	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	26.0	2029.0	78.0	-0.287	0.106	1000.0	-1000.0	-0.039	-1000.0
Signaling events regulated by Ret tyrosine kinase	25.0	2094.0	82.0	-0.125	0.014	1000.0	-1000.0	-0.043	-1000.0
IL4-mediated signaling events	24.0	2245.0	91.0	-0.7	0.56	1000.0	-1000.0	-0.129	-1000.0
Syndecan-1-mediated signaling events	22.0	766.0	34.0	-0.116	0.014	1000.0	-1000.0	-0.018	-1000.0
TCR signaling in naïve CD8+ T cells	22.0	2130.0	93.0	-0.238	0.02	1000.0	-1000.0	-0.042	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	22.0	1637.0	74.0	-0.132	0.045	1000.0	-1000.0	-0.044	-1000.0
IL23-mediated signaling events	20.0	1258.0	60.0	-0.361	0.014	1000.0	-1000.0	-0.082	-1000.0
Glypican 2 network	19.0	77.0	4.0	-0.029	-0.018	1000.0	-1000.0	-0.006	-1000.0
BCR signaling pathway	19.0	1938.0	99.0	-0.193	0.014	1000.0	-1000.0	-0.047	-1000.0
E-cadherin signaling in the nascent adherens junction	18.0	1378.0	76.0	-0.132	0.022	1000.0	-1000.0	-0.044	-1000.0
IL12-mediated signaling events	17.0	1547.0	87.0	-0.302	0.078	1000.0	-1000.0	-0.094	-1000.0
Glypican 1 network	17.0	825.0	48.0	-0.119	0.021	1000.0	-1000.0	-0.017	-1000.0
Wnt signaling	17.0	123.0	7.0	-0.064	-0.009	1000.0	-1000.0	-0.008	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	17.0	1170.0	68.0	-0.304	0.104	1000.0	-1000.0	-0.052	-1000.0
EGFR-dependent Endothelin signaling events	17.0	375.0	21.0	-0.092	0.02	1000.0	-1000.0	-0.031	-1000.0
Angiopoietin receptor Tie2-mediated signaling	16.0	1423.0	88.0	-0.2	0.04	1000.0	-1000.0	-0.05	-1000.0
E-cadherin signaling in keratinocytes	16.0	716.0	43.0	-0.132	0.017	1000.0	-1000.0	-0.019	-1000.0
LPA4-mediated signaling events	15.0	186.0	12.0	-0.095	0.014	1000.0	-1000.0	-0.009	-1000.0
Noncanonical Wnt signaling pathway	15.0	406.0	26.0	-0.064	0.014	1000.0	-1000.0	-0.018	-1000.0
p75(NTR)-mediated signaling	15.0	1968.0	125.0	-0.116	0.039	1000.0	-1000.0	-0.053	-1000.0
BMP receptor signaling	15.0	1256.0	81.0	-0.14	0.031	1000.0	-1000.0	-0.052	-1000.0
Endothelins	15.0	1514.0	96.0	-0.152	0.036	1000.0	-1000.0	-0.043	-1000.0
Glucocorticoid receptor regulatory network	14.0	1679.0	114.0	-0.367	0.253	1000.0	-1000.0	-0.036	-1000.0
FAS signaling pathway (CD95)	14.0	694.0	47.0	-0.07	0.046	1000.0	-1000.0	-0.024	-1000.0
LPA receptor mediated events	14.0	1514.0	102.0	-0.124	0.014	1000.0	-1000.0	-0.046	-1000.0
HIF-1-alpha transcription factor network	13.0	1026.0	76.0	-0.21	0.027	1000.0	-1000.0	-0.058	-1000.0
Nectin adhesion pathway	13.0	859.0	63.0	-0.132	0.022	1000.0	-1000.0	-0.042	-1000.0
Ephrin B reverse signaling	13.0	643.0	48.0	-0.081	0.026	1000.0	-1000.0	-0.025	-1000.0
TCGA08_p53	13.0	96.0	7.0	-0.091	0.066	1000.0	-1000.0	-0.011	-1000.0
Integrins in angiogenesis	13.0	1151.0	84.0	-0.13	0.02	1000.0	-1000.0	-0.043	-1000.0
EPHB forward signaling	13.0	1145.0	85.0	-0.104	0.073	1000.0	-1000.0	-0.048	-1000.0
Calcium signaling in the CD4+ TCR pathway	13.0	406.0	31.0	-0.166	0.014	1000.0	-1000.0	-0.044	-1000.0
Caspase cascade in apoptosis	12.0	902.0	74.0	-0.081	0.036	1000.0	-1000.0	-0.022	-1000.0
Osteopontin-mediated events	12.0	485.0	38.0	-0.065	0.014	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by the Hedgehog family	12.0	650.0	52.0	-0.166	0.016	1000.0	-1000.0	-0.017	-1000.0
Thromboxane A2 receptor signaling	12.0	1308.0	105.0	-0.092	0.023	1000.0	-1000.0	-0.038	-1000.0
a4b1 and a4b7 Integrin signaling	11.0	59.0	5.0	-0.027	-0.006	1000.0	-1000.0	-0.003	-1000.0
amb2 Integrin signaling	11.0	942.0	82.0	-0.086	0.018	1000.0	-1000.0	-0.031	-1000.0
Reelin signaling pathway	11.0	642.0	56.0	-0.102	0.025	1000.0	-1000.0	-0.038	-1000.0
Syndecan-4-mediated signaling events	11.0	772.0	67.0	-0.097	0.015	1000.0	-1000.0	-0.022	-1000.0
Class IB PI3K non-lipid kinase events	11.0	33.0	3.0	-0.018	-1000.0	1000.0	-1000.0	-0.001	-1000.0
S1P4 pathway	11.0	287.0	25.0	-0.078	0.02	1000.0	-1000.0	-0.014	-1000.0
Arf6 signaling events	10.0	646.0	62.0	-0.092	0.024	1000.0	-1000.0	-0.017	-1000.0
TRAIL signaling pathway	10.0	510.0	48.0	-0.042	0.014	1000.0	-1000.0	-0.023	-1000.0
Effects of Botulinum toxin	10.0	275.0	26.0	-0.083	0.017	1000.0	-1000.0	-0.014	-1000.0
IL27-mediated signaling events	10.0	550.0	51.0	-0.161	0.068	1000.0	-1000.0	-0.037	-1000.0
JNK signaling in the CD4+ TCR pathway	9.0	166.0	17.0	-0.047	0.014	1000.0	-1000.0	-0.017	-1000.0
Syndecan-2-mediated signaling events	9.0	648.0	69.0	-0.097	0.018	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by PTP1B	9.0	755.0	76.0	-0.094	0.027	1000.0	-1000.0	-0.035	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	9.0	481.0	52.0	-0.079	0.021	1000.0	-1000.0	-0.017	-1000.0
Signaling mediated by p38-alpha and p38-beta	9.0	424.0	44.0	-0.087	0.014	1000.0	-1000.0	-0.03	-1000.0
Fc-epsilon receptor I signaling in mast cells	8.0	794.0	97.0	-0.077	0.024	1000.0	-1000.0	-0.042	-1000.0
S1P5 pathway	8.0	136.0	17.0	-0.078	0.033	1000.0	-1000.0	-0.016	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	8.0	398.0	45.0	-0.103	0.032	1000.0	-1000.0	-0.048	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	8.0	1005.0	120.0	-0.114	0.106	1000.0	-1000.0	-0.041	-1000.0
Ras signaling in the CD4+ TCR pathway	8.0	148.0	17.0	-0.033	0.026	1000.0	-1000.0	-0.02	-1000.0
ErbB2/ErbB3 signaling events	7.0	457.0	65.0	-0.066	0.02	1000.0	-1000.0	-0.038	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	7.0	660.0	85.0	-0.05	0.014	1000.0	-1000.0	-0.043	-1000.0
FOXA2 and FOXA3 transcription factor networks	7.0	352.0	46.0	-0.286	0.02	1000.0	-1000.0	-0.075	-1000.0
PDGFR-alpha signaling pathway	7.0	338.0	44.0	-0.019	0.019	1000.0	-1000.0	-0.023	-1000.0
Ceramide signaling pathway	7.0	589.0	76.0	-0.092	0.05	1000.0	-1000.0	-0.025	-1000.0
Signaling mediated by p38-gamma and p38-delta	7.0	118.0	15.0	-0.026	0.014	1000.0	-1000.0	-0.013	-1000.0
IL2 signaling events mediated by PI3K	7.0	455.0	58.0	-0.071	0.03	1000.0	-1000.0	-0.026	-1000.0
IL2 signaling events mediated by STAT5	7.0	167.0	22.0	-0.065	0.014	1000.0	-1000.0	-0.021	-1000.0
Class I PI3K signaling events	7.0	544.0	73.0	-0.114	0.024	1000.0	-1000.0	-0.025	-1000.0
Plasma membrane estrogen receptor signaling	7.0	635.0	86.0	-0.114	0.027	1000.0	-1000.0	-0.043	-1000.0
Rapid glucocorticoid signaling	7.0	145.0	20.0	-0.076	0.014	1000.0	-1000.0	-0.005	-1000.0
Visual signal transduction: Rods	7.0	372.0	52.0	-0.045	0.014	1000.0	-1000.0	-0.045	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	179.0	28.0	-0.078	0.026	1000.0	-1000.0	-0.015	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	6.0	324.0	54.0	-0.102	0.024	1000.0	-1000.0	-0.052	-1000.0
Cellular roles of Anthrax toxin	6.0	239.0	39.0	-0.041	0.014	1000.0	-1000.0	-0.008	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	6.0	231.0	37.0	-0.027	0.027	1000.0	-1000.0	-0.015	-1000.0
IL1-mediated signaling events	6.0	423.0	62.0	-0.04	0.048	1000.0	-1000.0	-0.04	-1000.0
S1P1 pathway	6.0	242.0	36.0	-0.079	0.014	1000.0	-1000.0	-0.036	-1000.0
IGF1 pathway	6.0	389.0	57.0	-0.037	0.028	1000.0	-1000.0	-0.046	-1000.0
Coregulation of Androgen receptor activity	5.0	413.0	76.0	-0.129	0.029	1000.0	-1000.0	-0.018	-1000.0
ErbB4 signaling events	5.0	371.0	69.0	-0.155	0.116	1000.0	-1000.0	-0.05	-1000.0
Visual signal transduction: Cones	5.0	190.0	38.0	-0.034	0.013	1000.0	-1000.0	-0.009	-1000.0
IFN-gamma pathway	5.0	375.0	68.0	-0.082	0.025	1000.0	-1000.0	-0.052	-1000.0
Paxillin-dependent events mediated by a4b1	5.0	186.0	36.0	-0.027	0.035	1000.0	-1000.0	-0.028	-1000.0
Regulation of p38-alpha and p38-beta	5.0	315.0	54.0	-0.091	0.035	1000.0	-1000.0	-0.035	-1000.0
Nongenotropic Androgen signaling	5.0	307.0	52.0	-0.078	0.03	1000.0	-1000.0	-0.024	-1000.0
S1P3 pathway	5.0	229.0	42.0	-0.077	0.024	1000.0	-1000.0	-0.026	-1000.0
Regulation of Androgen receptor activity	5.0	353.0	70.0	-0.143	0.024	1000.0	-1000.0	-0.031	-1000.0
Regulation of nuclear SMAD2/3 signaling	4.0	636.0	136.0	-0.178	0.045	1000.0	-1000.0	-0.036	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	4.0	158.0	34.0	-0.024	0.014	1000.0	-1000.0	-0.014	-1000.0
PLK2 and PLK4 events	4.0	13.0	3.0	0.002	0.005	1000.0	-1000.0	-0.006	-1000.0
Hedgehog signaling events mediated by Gli proteins	4.0	276.0	65.0	-0.078	0.054	1000.0	-1000.0	-0.049	-1000.0
Presenilin action in Notch and Wnt signaling	4.0	285.0	61.0	-0.091	0.045	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class III	4.0	174.0	40.0	-0.114	0.024	1000.0	-1000.0	-0.012	-1000.0
ceramide signaling pathway	4.0	227.0	49.0	-0.054	0.02	1000.0	-1000.0	-0.021	-1000.0
Retinoic acid receptors-mediated signaling	4.0	238.0	58.0	-0.052	0.03	1000.0	-1000.0	-0.036	-1000.0
Atypical NF-kappaB pathway	4.0	148.0	31.0	-0.066	0.024	1000.0	-1000.0	-0.014	-1000.0
Syndecan-3-mediated signaling events	4.0	150.0	35.0	-0.086	0.039	1000.0	-1000.0	-0.025	-1000.0
Canonical Wnt signaling pathway	4.0	239.0	51.0	-0.091	0.046	1000.0	-1000.0	-0.033	-1000.0
IL6-mediated signaling events	4.0	302.0	75.0	-0.03	0.052	1000.0	-1000.0	-0.037	-1000.0
Regulation of Telomerase	4.0	414.0	102.0	-0.092	0.041	1000.0	-1000.0	-0.055	-1000.0
Insulin Pathway	4.0	316.0	74.0	-0.083	0.034	1000.0	-1000.0	-0.042	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	4.0	160.0	33.0	-0.13	0.037	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by PRL	4.0	136.0	34.0	-0.086	0.026	1000.0	-1000.0	-0.022	-1000.0
FOXM1 transcription factor network	4.0	234.0	51.0	-0.133	0.139	1000.0	-1000.0	-0.117	-1000.0
Aurora B signaling	4.0	270.0	67.0	-0.098	0.032	1000.0	-1000.0	-0.025	-1000.0
EPO signaling pathway	3.0	180.0	55.0	-0.026	0.03	1000.0	-1000.0	-0.046	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	3.0	315.0	83.0	-0.057	0.044	1000.0	-1000.0	-0.022	-1000.0
TCGA08_rtk_signaling	3.0	92.0	26.0	-0.042	0.033	1000.0	-1000.0	-0.01	-1000.0
Aurora C signaling	2.0	19.0	7.0	-0.011	0.009	1000.0	-1000.0	-0.011	-1000.0
Insulin-mediated glucose transport	2.0	69.0	32.0	-0.051	0.026	1000.0	-1000.0	-0.019	-1000.0
PDGFR-beta signaling pathway	2.0	277.0	97.0	-0.074	0.042	1000.0	-1000.0	-0.035	-1000.0
p38 MAPK signaling pathway	2.0	127.0	44.0	-0.052	0.026	1000.0	-1000.0	-0.036	-1000.0
Canonical NF-kappaB pathway	1.0	70.0	39.0	-0.023	0.055	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by HDAC Class II	1.0	116.0	75.0	-0.052	0.037	1000.0	-1000.0	-0.021	-1000.0
BARD1 signaling events	1.0	85.0	57.0	-0.026	0.047	1000.0	-1000.0	-0.027	-1000.0
Circadian rhythm pathway	1.0	38.0	22.0	-0.011	0.037	1000.0	-1000.0	-0.029	-1000.0
Aurora A signaling	1.0	94.0	60.0	-0.043	0.036	1000.0	-1000.0	-0.014	-1000.0
Arf6 downstream pathway	1.0	52.0	43.0	-0.019	0.025	1000.0	-1000.0	-0.014	-1000.0
mTOR signaling pathway	1.0	97.0	53.0	-0.009	0.025	1000.0	-1000.0	-0.031	-1000.0
HIF-2-alpha transcription factor network	1.0	59.0	43.0	-0.122	0.125	1000.0	-1000.0	-0.05	-1000.0
Signaling events mediated by HDAC Class I	1.0	165.0	104.0	-0.027	0.044	1000.0	-1000.0	-0.021	-1000.0
FoxO family signaling	1.0	102.0	64.0	-0.177	0.108	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	220.0	125.0	-0.063	0.047	1000.0	-1000.0	-0.048	-1000.0
Arf6 trafficking events	1.0	73.0	71.0	-0.036	0.033	1000.0	-1000.0	-0.029	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	6.0	23.0	0.005	0.037	1000.0	-1000.0	-0.02	-1000.0
PLK1 signaling events	0.0	77.0	85.0	-0.004	0.032	1000.0	-1000.0	-0.027	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	52.0	68.0	-0.051	0.041	1000.0	-1000.0	-0.02	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.0	0.032	1000.0	-1000.0	-0.026	-1000.0
VEGFR1 specific signals	0.0	55.0	56.0	-0.024	0.036	1000.0	-1000.0	-0.023	-1000.0
Arf1 pathway	0.0	22.0	54.0	-0.007	0.024	1000.0	-1000.0	-0.009	-1000.0
Alternative NF-kappaB pathway	0.0	3.0	13.0	0.0	0.039	1000.0	-1000.0	-0.005	-1000.0
Total	1146	66376	7203	-12.6291392548	-995.013054887	131000	-131000	-4.05856983411	-131000