E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.106 0.19 -9999.0 0.0 -0.381 46.0 46.0 KLHL20 -0.024 0.097 0.192 5.0 -0.211 12.0 17.0 CYFIP2 0.015 0.064 -9999.0 0.0 -0.319 5.0 5.0 Rac1/GDP -0.052 0.121 0.24 1.0 -0.232 37.0 38.0 ENAH -0.1 0.184 -9999.0 0.0 -0.385 40.0 40.0 AP1M1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.022 0.087 -9999.0 0.0 -0.195 3.0 3.0 ABI1/Sra1/Nap1 -0.04 0.052 -9999.0 0.0 -0.142 14.0 14.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.007 0.112 -9999.0 0.0 -0.17 45.0 45.0 RAPGEF1 -0.081 0.174 0.228 2.0 -0.342 41.0 43.0 CTNND1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.101 0.198 -9999.0 0.0 -0.388 46.0 46.0 CRK -0.09 0.18 0.211 1.0 -0.368 40.0 41.0 E-cadherin/gamma catenin/alpha catenin -0.017 0.113 -9999.0 0.0 -0.19 42.0 42.0 alphaE/beta7 Integrin 0.032 0.045 -9999.0 0.0 -0.222 4.0 4.0 IQGAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.043 0.032 -9999.0 0.0 -0.157 2.0 2.0 DLG1 -0.103 0.188 -9999.0 0.0 -0.379 45.0 45.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.042 0.05 -9999.0 0.0 -0.123 35.0 35.0 MLLT4 0.02 0.041 -9999.0 0.0 -0.319 2.0 2.0 ARF6/GTP/NME1/Tiam1 0.043 0.043 -9999.0 0.0 -0.168 5.0 5.0 PI3K -0.051 0.064 -9999.0 0.0 -0.155 33.0 33.0 ARF6 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.036 0.123 -9999.0 0.0 -0.226 42.0 42.0 TIAM1 0.016 0.064 -9999.0 0.0 -0.319 5.0 5.0 E-cadherin(dimer)/Ca2+ -0.001 0.104 -9999.0 0.0 -0.16 42.0 42.0 AKT1 -0.025 0.053 0.139 2.0 -0.13 2.0 4.0 PIK3R1 0.025 0.029 -9999.0 0.0 -0.319 1.0 1.0 CDH1 -0.07 0.16 -9999.0 0.0 -0.319 42.0 42.0 RhoA/GDP -0.047 0.13 0.252 2.0 -0.231 39.0 41.0 actin cytoskeleton organization -0.015 0.077 0.164 6.0 -0.154 12.0 18.0 CDC42/GDP -0.048 0.131 0.252 2.0 -0.231 39.0 41.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.042 0.098 -9999.0 0.0 -0.192 42.0 42.0 ITGB7 0.02 0.058 0.113 1.0 -0.319 4.0 5.0 RAC1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.0 0.112 -9999.0 0.0 -0.171 42.0 42.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.011 0.094 -9999.0 0.0 -0.156 42.0 42.0 mol:GDP -0.065 0.139 0.255 2.0 -0.261 39.0 41.0 CDC42/GTP/IQGAP1 0.037 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.026 0.03 -9999.0 0.0 -0.319 1.0 1.0 p120 catenin/RhoA/GDP -0.041 0.136 0.257 2.0 -0.235 38.0 40.0 RAC1/GTP/IQGAP1 0.033 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.043 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.006 0.058 0.134 8.0 -0.101 10.0 18.0 NME1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.105 0.19 -9999.0 0.0 -0.38 46.0 46.0 regulation of cell-cell adhesion -0.029 0.069 -9999.0 0.0 -0.14 35.0 35.0 WASF2 -0.012 0.041 0.09 3.0 -0.087 5.0 8.0 Rap1/GTP -0.022 0.098 0.21 2.0 -0.214 3.0 5.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.0 0.114 -9999.0 0.0 -0.164 45.0 45.0 CCND1 -0.008 0.068 0.153 8.0 -0.122 10.0 18.0 VAV2 -0.119 0.244 -9999.0 0.0 -0.645 13.0 13.0 RAP1/GDP -0.029 0.111 0.261 1.0 -0.256 4.0 5.0 adherens junction assembly -0.101 0.186 -9999.0 0.0 -0.369 46.0 46.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.03 -9999.0 0.0 -0.319 1.0 1.0 PIP5K1C 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.01 0.105 0.19 2.0 -0.161 44.0 46.0 E-cadherin/beta catenin -0.07 0.131 -9999.0 0.0 -0.277 41.0 41.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.099 0.186 0.219 1.0 -0.382 42.0 43.0 PIK3CA 0.026 0.029 -9999.0 0.0 -0.319 1.0 1.0 Rac1/GTP -0.074 0.12 -9999.0 0.0 -0.331 13.0 13.0 E-cadherin/beta catenin/alpha catenin -0.015 0.112 -9999.0 0.0 -0.187 42.0 42.0 ITGAE 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.103 0.202 -9999.0 0.0 -0.396 46.0 46.0