Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.011 0.123 -9999.0 0.0 -0.411 10.0 10.0 IHH 0.029 0.055 0.141 2.0 -0.135 12.0 14.0 SHH Np/Cholesterol/GAS1 0.014 0.029 -9999.0 0.0 -0.169 3.0 3.0 LRPAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.014 0.029 0.168 3.0 -9999.0 0.0 3.0 SMO/beta Arrestin2 0.012 0.133 -9999.0 0.0 -0.389 7.0 7.0 SMO -0.011 0.122 -9999.0 0.0 -0.391 9.0 9.0 AKT1 -0.006 0.112 -9999.0 0.0 -0.391 7.0 7.0 ARRB2 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.022 0.06 -9999.0 0.0 -0.319 4.0 4.0 ADRBK1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.01 0.12 -9999.0 0.0 -0.386 9.0 9.0 STIL 0.022 0.093 0.189 20.0 -0.247 7.0 27.0 DHH N/PTCH2 0.033 0.07 0.165 2.0 -0.222 9.0 11.0 DHH N/PTCH1 0.017 0.12 -9999.0 0.0 -0.354 11.0 11.0 PIK3CA 0.026 0.029 -9999.0 0.0 -0.319 1.0 1.0 DHH 0.018 0.086 0.113 16.0 -0.319 8.0 24.0 PTHLH -0.009 0.184 -9999.0 0.0 -0.585 12.0 12.0 determination of left/right symmetry -0.01 0.12 -9999.0 0.0 -0.386 9.0 9.0 PIK3R1 0.025 0.029 -9999.0 0.0 -0.319 1.0 1.0 skeletal system development -0.009 0.183 -9999.0 0.0 -0.58 12.0 12.0 IHH N/Hhip 0.04 0.042 0.184 1.0 -9999.0 0.0 1.0 DHH N/Hhip 0.034 0.068 0.165 2.0 -0.223 8.0 10.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.01 0.12 -9999.0 0.0 -0.386 9.0 9.0 pancreas development 0.029 0.02 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.019 0.05 -9999.0 0.0 -0.319 3.0 3.0 PI3K 0.036 0.033 -9999.0 0.0 -0.222 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.025 0.03 -9999.0 0.0 -0.319 1.0 1.0 somite specification -0.01 0.12 -9999.0 0.0 -0.386 9.0 9.0 SHH Np/Cholesterol/PTCH1 0.006 0.071 -9999.0 0.0 -0.246 8.0 8.0 SHH Np/Cholesterol/PTCH2 0.019 0.034 0.195 1.0 -0.171 3.0 4.0 SHH Np/Cholesterol/Megalin 0.006 0.104 0.195 11.0 -0.174 29.0 40.0 SHH -0.008 0.029 -9999.0 0.0 -0.226 2.0 2.0 catabolic process 0.006 0.111 -9999.0 0.0 -0.369 11.0 11.0 SMO/Vitamin D3 0.006 0.102 0.234 3.0 -0.308 8.0 11.0 SHH Np/Cholesterol/Hhip 0.012 0.034 0.195 1.0 -0.169 2.0 3.0 LRP2 -0.02 0.16 -9999.0 0.0 -0.319 31.0 31.0 receptor-mediated endocytosis -0.028 0.127 -9999.0 0.0 -0.354 11.0 11.0 SHH Np/Cholesterol/BOC 0.018 0.038 0.195 1.0 -0.171 4.0 5.0 SHH Np/Cholesterol/CDO 0.014 0.038 -9999.0 0.0 -0.22 3.0 3.0 mesenchymal cell differentiation -0.012 0.034 0.168 2.0 -0.193 1.0 3.0 mol:Vitamin D3 0.037 0.102 0.215 21.0 -0.247 8.0 29.0 IHH N/PTCH2 0.039 0.047 0.184 1.0 -0.246 1.0 2.0 CDON 0.022 0.041 -9999.0 0.0 -0.319 2.0 2.0 IHH N/PTCH1 0.016 0.117 -9999.0 0.0 -0.371 11.0 11.0 Megalin/LRPAP1 0.003 0.121 -9999.0 0.0 -0.221 31.0 31.0 PTCH2 0.029 0.032 -9999.0 0.0 -0.319 1.0 1.0 SHH Np/Cholesterol 0.01 0.022 -9999.0 0.0 -0.167 2.0 2.0 PTCH1 0.006 0.111 -9999.0 0.0 -0.37 11.0 11.0 HHIP 0.029 0.02 -9999.0 0.0 -9999.0 0.0 0.0