Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.038 0.096 -9999.0 0.0 -0.184 43.0 43.0 epithelial cell differentiation -0.005 0.1 -9999.0 0.0 -0.159 42.0 42.0 CYFIP2 0.015 0.064 -9999.0 0.0 -0.319 5.0 5.0 ENAH -0.046 0.072 0.419 1.0 -0.213 2.0 3.0 EGFR 0.025 0.055 -9999.0 0.0 -0.319 3.0 3.0 EPHA2 0.018 0.065 -9999.0 0.0 -0.319 5.0 5.0 MYO6 -0.052 0.079 0.173 4.0 -0.247 3.0 7.0 CTNNB1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.042 0.049 -9999.0 0.0 -0.175 6.0 6.0 AQP5 -0.025 0.075 0.21 1.0 -0.4 1.0 2.0 CTNND1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.048 0.073 0.172 4.0 -9999.0 0.0 4.0 regulation of calcium-dependent cell-cell adhesion -0.047 0.077 0.19 3.0 -0.288 1.0 4.0 EGF -0.028 0.138 -9999.0 0.0 -0.319 26.0 26.0 NCKAP1 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.053 0.106 -9999.0 0.0 -0.316 13.0 13.0 cortical microtubule organization -0.005 0.1 -9999.0 0.0 -0.159 42.0 42.0 GO:0000145 -0.046 0.069 0.161 4.0 -9999.0 0.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.001 0.104 -9999.0 0.0 -0.16 42.0 42.0 MLLT4 0.02 0.041 -9999.0 0.0 -0.319 2.0 2.0 ARF6/GDP -0.057 0.06 -9999.0 0.0 -0.153 37.0 37.0 ARF6 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.057 0.051 -9999.0 0.0 -0.168 5.0 5.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.038 0.065 0.162 2.0 -9999.0 0.0 2.0 PVRL2 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.047 0.069 0.166 2.0 -9999.0 0.0 2.0 ARF6/GTP 0.061 0.053 -9999.0 0.0 -0.159 5.0 5.0 CDH1 -0.07 0.16 -9999.0 0.0 -0.319 42.0 42.0 EGFR/EGFR/EGF/EGF -0.042 0.115 -9999.0 0.0 -0.175 58.0 58.0 RhoA/GDP -0.002 0.099 -9999.0 0.0 -0.154 42.0 42.0 actin cytoskeleton organization -0.054 0.079 0.157 4.0 -0.166 38.0 42.0 IGF-1R heterotetramer 0.026 0.029 -9999.0 0.0 -0.319 1.0 1.0 GIT1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.026 0.029 -9999.0 0.0 -0.319 1.0 1.0 IGF1 0.002 0.097 -9999.0 0.0 -0.319 12.0 12.0 DIAPH1 -0.034 0.218 -9999.0 0.0 -0.583 14.0 14.0 Wnt receptor signaling pathway 0.005 0.1 0.159 42.0 -9999.0 0.0 42.0 RHOA 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.057 0.06 -9999.0 0.0 -0.154 37.0 37.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.055 0.08 0.159 4.0 -0.169 38.0 42.0 EFNA1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.053 0.07 0.167 3.0 -9999.0 0.0 3.0 Ephrin A1/EPHA2 -0.011 0.093 -9999.0 0.0 -0.157 40.0 40.0 SEC6/SEC8 -0.05 0.06 -9999.0 0.0 -0.153 32.0 32.0 MGAT3 -0.048 0.078 0.192 3.0 -0.292 1.0 4.0 HGF/MET -0.029 0.107 -9999.0 0.0 -0.169 49.0 49.0 HGF 0.014 0.078 -9999.0 0.0 -0.319 7.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.038 0.097 -9999.0 0.0 -0.186 43.0 43.0 actin cable formation -0.019 0.106 0.302 6.0 -0.263 5.0 11.0 KIAA1543 -0.048 0.07 0.162 4.0 -0.149 38.0 42.0 KIFC3 -0.054 0.07 0.174 2.0 -9999.0 0.0 2.0 NCK1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.051 0.075 0.173 4.0 -9999.0 0.0 4.0 NCK1/GIT1 0.04 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.005 0.1 -9999.0 0.0 -0.159 42.0 42.0 EXOC4 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.049 0.075 0.173 4.0 -9999.0 0.0 4.0 PIP5K1C -0.049 0.074 0.173 4.0 -9999.0 0.0 4.0 LIMA1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.03 -9999.0 0.0 -0.319 1.0 1.0 ROCK1 -0.039 0.094 0.353 3.0 -0.23 1.0 4.0 adherens junction assembly -0.046 0.084 0.245 1.0 -0.341 3.0 4.0 IGF-1R heterotetramer/IGF1 -0.022 0.107 -9999.0 0.0 -0.167 48.0 48.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.033 0.034 -9999.0 0.0 -0.222 2.0 2.0 MET -0.001 0.098 -9999.0 0.0 -0.319 12.0 12.0 PLEKHA7 -0.05 0.075 0.173 4.0 -0.157 1.0 5.0 mol:GTP 0.055 0.05 -9999.0 0.0 -0.167 5.0 5.0 establishment of epithelial cell apical/basal polarity -0.019 0.108 0.315 4.0 -9999.0 0.0 4.0 cortical actin cytoskeleton stabilization -0.038 0.096 -9999.0 0.0 -0.184 43.0 43.0 regulation of cell-cell adhesion -0.054 0.079 0.157 4.0 -0.166 38.0 42.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.038 0.097 -9999.0 0.0 -0.186 43.0 43.0