Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	25.0	178.0	7.0	-0.035	0.0	1000.0	-1000.0	-0.0	-1000.0
E-cadherin signaling events	25.0	127.0	5.0	-0.07	0.029	1000.0	-1000.0	0.019	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	25.0	1990.0	78.0	-0.252	0.082	1000.0	-1000.0	-0.025	-1000.0
IL4-mediated signaling events	22.0	2007.0	91.0	-0.548	0.419	1000.0	-1000.0	-0.058	-1000.0
TCR signaling in naïve CD8+ T cells	21.0	1970.0	93.0	-0.214	0.158	1000.0	-1000.0	-0.033	-1000.0
Signaling events regulated by Ret tyrosine kinase	20.0	1655.0	82.0	-0.063	0.033	1000.0	-1000.0	-0.029	-1000.0
IL23-mediated signaling events	20.0	1215.0	60.0	-0.303	0.029	1000.0	-1000.0	-0.057	-1000.0
E-cadherin signaling in the nascent adherens junction	18.0	1427.0	76.0	-0.119	0.043	1000.0	-1000.0	-0.034	-1000.0
Endothelins	17.0	1701.0	96.0	-0.126	0.054	1000.0	-1000.0	-0.029	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	17.0	1169.0	68.0	-0.262	0.083	1000.0	-1000.0	-0.055	-1000.0
BCR signaling pathway	16.0	1637.0	99.0	-0.142	0.04	1000.0	-1000.0	-0.04	-1000.0
E-cadherin signaling in keratinocytes	16.0	719.0	43.0	-0.075	0.031	1000.0	-1000.0	-0.017	-1000.0
IL12-mediated signaling events	15.0	1387.0	87.0	-0.247	0.071	1000.0	-1000.0	-0.04	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	15.0	1137.0	74.0	-0.07	0.061	1000.0	-1000.0	-0.039	-1000.0
Angiopoietin receptor Tie2-mediated signaling	15.0	1375.0	88.0	-0.167	0.037	1000.0	-1000.0	-0.049	-1000.0
Syndecan-1-mediated signaling events	13.0	454.0	34.0	-0.044	0.029	1000.0	-1000.0	-0.018	-1000.0
Osteopontin-mediated events	13.0	512.0	38.0	-0.049	0.036	1000.0	-1000.0	-0.016	-1000.0
Nectin adhesion pathway	13.0	867.0	63.0	-0.088	0.043	1000.0	-1000.0	-0.026	-1000.0
EPHB forward signaling	13.0	1144.0	85.0	-0.062	0.048	1000.0	-1000.0	-0.041	-1000.0
Noncanonical Wnt signaling pathway	12.0	315.0	26.0	-0.042	0.028	1000.0	-1000.0	-0.024	-1000.0
Thromboxane A2 receptor signaling	12.0	1300.0	105.0	-0.084	0.035	1000.0	-1000.0	-0.024	-1000.0
p75(NTR)-mediated signaling	12.0	1562.0	125.0	-0.054	0.074	1000.0	-1000.0	-0.043	-1000.0
Ephrin B reverse signaling	12.0	619.0	48.0	-0.077	0.03	1000.0	-1000.0	-0.031	-1000.0
FAS signaling pathway (CD95)	12.0	609.0	47.0	-0.031	0.038	1000.0	-1000.0	-0.032	-1000.0
Integrins in angiogenesis	12.0	1046.0	84.0	-0.109	0.054	1000.0	-1000.0	-0.024	-1000.0
LPA receptor mediated events	12.0	1280.0	102.0	-0.082	0.034	1000.0	-1000.0	-0.068	-1000.0
EGFR-dependent Endothelin signaling events	12.0	265.0	21.0	-0.037	0.041	1000.0	-1000.0	-0.028	-1000.0
HIF-1-alpha transcription factor network	11.0	862.0	76.0	-0.051	0.062	1000.0	-1000.0	-0.017	-1000.0
Glucocorticoid receptor regulatory network	11.0	1301.0	114.0	-0.234	0.119	1000.0	-1000.0	-0.033	-1000.0
Glypican 2 network	11.0	45.0	4.0	0.01	0.013	1000.0	-1000.0	0.021	-1000.0
Wnt signaling	11.0	82.0	7.0	-0.03	0.025	1000.0	-1000.0	0.003	-1000.0
Class IB PI3K non-lipid kinase events	11.0	33.0	3.0	-0.005	0.005	1000.0	-1000.0	-0.023	-1000.0
Caspase cascade in apoptosis	10.0	780.0	74.0	-0.063	0.042	1000.0	-1000.0	-0.021	-1000.0
Arf6 signaling events	10.0	639.0	62.0	-0.029	0.057	1000.0	-1000.0	-0.03	-1000.0
Glypican 1 network	10.0	499.0	48.0	-0.039	0.048	1000.0	-1000.0	-0.021	-1000.0
Ceramide signaling pathway	10.0	790.0	76.0	-0.044	0.058	1000.0	-1000.0	-0.02	-1000.0
Signaling mediated by p38-alpha and p38-beta	10.0	444.0	44.0	-0.06	0.034	1000.0	-1000.0	-0.008	-1000.0
TCGA08_retinoblastoma	10.0	87.0	8.0	-0.007	0.04	1000.0	-1000.0	-0.007	-1000.0
S1P4 pathway	10.0	250.0	25.0	-0.042	0.036	1000.0	-1000.0	-0.014	-1000.0
JNK signaling in the CD4+ TCR pathway	9.0	156.0	17.0	-0.078	0.043	1000.0	-1000.0	-0.025	-1000.0
a4b1 and a4b7 Integrin signaling	9.0	46.0	5.0	0.005	0.023	1000.0	-1000.0	0.021	-1000.0
BMP receptor signaling	9.0	780.0	81.0	-0.054	0.05	1000.0	-1000.0	-0.018	-1000.0
Fc-epsilon receptor I signaling in mast cells	9.0	948.0	97.0	-0.053	0.051	1000.0	-1000.0	-0.042	-1000.0
amb2 Integrin signaling	9.0	772.0	82.0	-0.036	0.044	1000.0	-1000.0	-0.016	-1000.0
Reelin signaling pathway	9.0	518.0	56.0	-0.02	0.059	1000.0	-1000.0	-0.016	-1000.0
Effects of Botulinum toxin	9.0	255.0	26.0	-0.028	0.044	1000.0	-1000.0	-0.002	-1000.0
Calcium signaling in the CD4+ TCR pathway	9.0	296.0	31.0	-0.071	0.029	1000.0	-1000.0	-0.027	-1000.0
Syndecan-4-mediated signaling events	9.0	616.0	67.0	-0.041	0.037	1000.0	-1000.0	-0.027	-1000.0
Plasma membrane estrogen receptor signaling	9.0	817.0	86.0	-0.127	0.084	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by the Hedgehog family	8.0	430.0	52.0	-0.028	0.04	1000.0	-1000.0	-0.019	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	8.0	695.0	85.0	-0.029	0.039	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by PTP1B	8.0	673.0	76.0	-0.046	0.044	1000.0	-1000.0	-0.02	-1000.0
IFN-gamma pathway	8.0	566.0	68.0	-0.031	0.039	1000.0	-1000.0	-0.03	-1000.0
TRAIL signaling pathway	8.0	399.0	48.0	-0.024	0.05	1000.0	-1000.0	-0.017	-1000.0
ceramide signaling pathway	8.0	440.0	49.0	-0.029	0.042	1000.0	-1000.0	-0.028	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	8.0	419.0	52.0	-0.051	0.064	1000.0	-1000.0	-0.026	-1000.0
Signaling mediated by p38-gamma and p38-delta	8.0	134.0	15.0	-0.016	0.029	1000.0	-1000.0	-0.021	-1000.0
IL2 signaling events mediated by PI3K	8.0	505.0	58.0	-0.096	0.039	1000.0	-1000.0	-0.033	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	8.0	369.0	45.0	-0.051	0.057	1000.0	-1000.0	-0.028	-1000.0
Class I PI3K signaling events	8.0	608.0	73.0	-0.087	0.05	1000.0	-1000.0	-0.025	-1000.0
ErbB2/ErbB3 signaling events	7.0	504.0	65.0	-0.039	0.041	1000.0	-1000.0	-0.058	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	7.0	380.0	54.0	-0.023	0.041	1000.0	-1000.0	-0.014	-1000.0
EPO signaling pathway	7.0	427.0	55.0	0.001	0.049	1000.0	-1000.0	-0.015	-1000.0
S1P5 pathway	7.0	131.0	17.0	-0.035	0.032	1000.0	-1000.0	-0.004	-1000.0
IL27-mediated signaling events	7.0	394.0	51.0	-0.167	0.073	1000.0	-1000.0	-0.036	-1000.0
IGF1 pathway	7.0	410.0	57.0	-0.028	0.057	1000.0	-1000.0	-0.018	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	7.0	845.0	120.0	-0.062	0.072	1000.0	-1000.0	-0.033	-1000.0
Ras signaling in the CD4+ TCR pathway	7.0	129.0	17.0	-0.018	0.052	1000.0	-1000.0	-0.014	-1000.0
LPA4-mediated signaling events	6.0	80.0	12.0	-0.044	0.006	1000.0	-1000.0	-0.018	-1000.0
Syndecan-2-mediated signaling events	6.0	474.0	69.0	-0.009	0.045	1000.0	-1000.0	-0.025	-1000.0
IL1-mediated signaling events	6.0	404.0	62.0	-0.011	0.075	1000.0	-1000.0	-0.022	-1000.0
S1P1 pathway	6.0	217.0	36.0	-0.052	0.029	1000.0	-1000.0	-0.02	-1000.0
IL2 signaling events mediated by STAT5	6.0	136.0	22.0	-0.036	0.029	1000.0	-1000.0	-0.015	-1000.0
PDGFR-beta signaling pathway	6.0	628.0	97.0	-0.056	0.064	1000.0	-1000.0	-0.032	-1000.0
Regulation of Androgen receptor activity	6.0	448.0	70.0	-0.083	0.037	1000.0	-1000.0	-0.025	-1000.0
Sphingosine 1-phosphate (S1P) pathway	5.0	145.0	28.0	-0.035	0.045	1000.0	-1000.0	-0.01	-1000.0
Cellular roles of Anthrax toxin	5.0	199.0	39.0	-0.033	0.029	1000.0	-1000.0	-0.014	-1000.0
FOXA2 and FOXA3 transcription factor networks	5.0	269.0	46.0	-0.197	0.034	1000.0	-1000.0	-0.058	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	5.0	192.0	37.0	-0.028	0.051	1000.0	-1000.0	-0.018	-1000.0
Paxillin-dependent events mediated by a4b1	5.0	185.0	36.0	-0.041	0.048	1000.0	-1000.0	-0.033	-1000.0
Regulation of p38-alpha and p38-beta	5.0	311.0	54.0	-0.055	0.057	1000.0	-1000.0	-0.037	-1000.0
Insulin Pathway	5.0	397.0	74.0	-0.078	0.072	1000.0	-1000.0	-0.028	-1000.0
S1P3 pathway	5.0	215.0	42.0	-0.034	0.044	1000.0	-1000.0	-0.019	-1000.0
Visual signal transduction: Rods	5.0	278.0	52.0	-0.002	0.045	1000.0	-1000.0	-0.011	-1000.0
Regulation of nuclear SMAD2/3 signaling	4.0	671.0	136.0	-0.295	0.074	1000.0	-1000.0	-0.031	-1000.0
Hedgehog signaling events mediated by Gli proteins	4.0	263.0	65.0	-0.047	0.068	1000.0	-1000.0	-0.03	-1000.0
Presenilin action in Notch and Wnt signaling	4.0	257.0	61.0	-0.016	0.074	1000.0	-1000.0	-0.032	-1000.0
PDGFR-alpha signaling pathway	4.0	208.0	44.0	-0.02	0.059	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by HDAC Class III	4.0	167.0	40.0	-0.062	0.046	1000.0	-1000.0	-0.038	-1000.0
HIF-2-alpha transcription factor network	4.0	209.0	43.0	-0.101	0.103	1000.0	-1000.0	-0.035	-1000.0
TCGA08_p53	4.0	32.0	7.0	-0.006	0.026	1000.0	-1000.0	-0.003	-1000.0
Retinoic acid receptors-mediated signaling	4.0	262.0	58.0	-0.038	0.055	1000.0	-1000.0	-0.022	-1000.0
Atypical NF-kappaB pathway	4.0	129.0	31.0	-0.015	0.036	1000.0	-1000.0	-0.01	-1000.0
Canonical Wnt signaling pathway	4.0	224.0	51.0	-0.015	0.061	1000.0	-1000.0	-0.023	-1000.0
Nongenotropic Androgen signaling	4.0	252.0	52.0	-0.051	0.045	1000.0	-1000.0	-0.018	-1000.0
IL6-mediated signaling events	4.0	339.0	75.0	-0.029	0.075	1000.0	-1000.0	-0.036	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	4.0	141.0	33.0	-0.003	0.065	1000.0	-1000.0	-0.015	-1000.0
Rapid glucocorticoid signaling	4.0	80.0	20.0	-0.008	0.032	1000.0	-1000.0	-0.002	-1000.0
FOXM1 transcription factor network	4.0	220.0	51.0	-0.019	0.084	1000.0	-1000.0	-0.076	-1000.0
Aurora B signaling	4.0	297.0	67.0	-0.078	0.063	1000.0	-1000.0	-0.026	-1000.0
Coregulation of Androgen receptor activity	3.0	277.0	76.0	-0.075	0.049	1000.0	-1000.0	-0.017	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	3.0	121.0	34.0	-0.04	0.071	1000.0	-1000.0	-0.032	-1000.0
ErbB4 signaling events	3.0	228.0	69.0	-0.072	0.079	1000.0	-1000.0	-0.022	-1000.0
PLK2 and PLK4 events	3.0	9.0	3.0	0.004	0.024	1000.0	-1000.0	-0.003	-1000.0
Visual signal transduction: Cones	3.0	116.0	38.0	-0.013	0.048	1000.0	-1000.0	-0.006	-1000.0
Arf6 downstream pathway	3.0	133.0	43.0	-0.044	0.05	1000.0	-1000.0	-0.03	-1000.0
mTOR signaling pathway	3.0	197.0	53.0	-0.032	0.036	1000.0	-1000.0	-0.019	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	3.0	312.0	83.0	-0.023	0.055	1000.0	-1000.0	-0.015	-1000.0
TCGA08_rtk_signaling	3.0	100.0	26.0	-0.024	0.065	1000.0	-1000.0	-0.005	-1000.0
Regulation of Telomerase	3.0	371.0	102.0	-0.095	0.063	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by PRL	3.0	105.0	34.0	-0.026	0.057	1000.0	-1000.0	-0.032	-1000.0
PLK1 signaling events	2.0	205.0	85.0	-0.009	0.055	1000.0	-1000.0	-0.025	-1000.0
Class I PI3K signaling events mediated by Akt	2.0	169.0	68.0	-0.041	0.053	1000.0	-1000.0	-0.016	-1000.0
FoxO family signaling	2.0	168.0	64.0	-0.165	0.042	1000.0	-1000.0	-0.043	-1000.0
Syndecan-3-mediated signaling events	2.0	78.0	35.0	-0.0	0.074	1000.0	-1000.0	-0.019	-1000.0
p38 MAPK signaling pathway	2.0	108.0	44.0	-0.035	0.047	1000.0	-1000.0	-0.012	-1000.0
Canonical NF-kappaB pathway	1.0	77.0	39.0	-0.01	0.059	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by HDAC Class II	1.0	84.0	75.0	-0.03	0.075	1000.0	-1000.0	-0.018	-1000.0
BARD1 signaling events	1.0	107.0	57.0	-0.058	0.066	1000.0	-1000.0	-0.043	-1000.0
Circadian rhythm pathway	1.0	24.0	22.0	-0.007	0.047	1000.0	-1000.0	-0.021	-1000.0
Aurora A signaling	1.0	99.0	60.0	-0.017	0.061	1000.0	-1000.0	-0.007	-1000.0
Aurora C signaling	1.0	13.0	7.0	-0.0	0.044	1000.0	-1000.0	-0.009	-1000.0
Insulin-mediated glucose transport	1.0	54.0	32.0	-0.021	0.051	1000.0	-1000.0	-0.01	-1000.0
Signaling events mediated by HDAC Class I	1.0	179.0	104.0	-0.054	0.068	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	245.0	125.0	-0.014	0.072	1000.0	-1000.0	-0.019	-1000.0
Arf6 trafficking events	1.0	116.0	71.0	-0.043	0.052	1000.0	-1000.0	-0.036	-1000.0
VEGFR1 specific signals	1.0	60.0	56.0	-0.028	0.055	1000.0	-1000.0	-0.029	-1000.0
Arf1 pathway	1.0	71.0	54.0	-0.001	0.043	1000.0	-1000.0	-0.008	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	7.0	23.0	0.003	0.058	1000.0	-1000.0	-0.008	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	-0.011	0.07	1000.0	-1000.0	-0.021	-1000.0
Alternative NF-kappaB pathway	0.0	3.0	13.0	0.0	0.071	1000.0	-1000.0	-0.0	-1000.0
Total	1000	61308	7203	-7.98573404776	7.00770752736	131000	-131000	-3.11231601238	-131000