rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CDKN2A(2), E2F1(1), PRB1(5), TP53(2) 422815 10 6 10 3 4 0 1 1 4 0 0.342 0.00149 0.916 2 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 SP1(2), TP53(2) 351795 4 4 4 1 0 0 2 1 1 0 0.690 0.0252 1.000 3 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), MARS(3), MAT1A(2), PAPSS1(1), PAPSS2(3), SCLY(1) 615278 11 7 11 2 7 2 0 1 1 0 0.0773 0.0549 1.000 4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNE1(1), CCNE2(3), CDKN2A(2), E2F1(1), PRB1(5) 448780 12 8 11 3 5 0 0 4 3 0 0.274 0.0551 1.000 5 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), EHHADH(2), HADHA(2), SDS(1) 240462 6 5 6 0 5 0 0 0 1 0 0.0445 0.0651 1.000 6 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), AGTR1(2), AGTR2(1), BDKRB2(3), KNG1(1), NOS3(3), REN(2) 489373 14 8 14 4 6 0 1 4 3 0 0.131 0.0724 1.000 7 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(2), CRY1(2), PER1(1) 417978 5 4 4 0 1 1 0 1 2 0 0.350 0.0817 1.000 8 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(3), CD38(2), ENPP1(1), ENPP3(1), NADSYN1(2), NNMT(1), NT5E(1), QPRT(1) 714118 12 7 12 2 7 1 0 2 2 0 0.132 0.0835 1.000 9 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(3), NR1H4(2), RXRA(1) 270174 6 4 6 1 3 2 1 0 0 0 0.167 0.0868 1.000 10 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), HGD(2) 111602 3 3 3 2 1 1 1 0 0 0 0.750 0.0929 1.000 11 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 15 CDKN2A(2), E2F1(1), POLR1A(2), POLR1B(1), RB1(1), TP53(2) 980254 9 8 9 3 3 0 1 1 4 0 0.447 0.0962 1.000 12 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(1), BAX(1), BCL2(1), CCNE1(1), E2F1(1), RB1(1), TP53(2) 883898 8 7 8 1 3 0 2 0 3 0 0.250 0.0985 1.000 13 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD34(1), CD3D(1), IL6(1) 302696 4 4 4 1 1 0 1 0 2 0 0.352 0.130 1.000 14 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 RB1(1), SP1(2) 328596 3 3 3 1 0 0 1 1 1 0 0.639 0.132 1.000 15 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 JAK2(1), LIN7A(1), NFKB1(1), RB1(1), TP53(2), USH1C(4) 885827 10 8 10 3 3 0 1 3 3 0 0.493 0.135 1.000 16 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1), SLPI(1) 85455 2 2 2 0 0 1 0 1 0 0 0.532 0.136 1.000 17 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(2), ITGA4(1), ITGAL(2), ITGAM(3), SELE(9), SELP(1) 760406 18 7 18 4 14 0 0 1 3 0 0.0911 0.145 1.000 18 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(2), ITGAL(2), ITGAM(3), SELE(9) 497480 16 6 16 3 13 0 0 1 2 0 0.0342 0.148 1.000 19 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 HLA-DRA(2) 116716 2 2 2 0 2 0 0 0 0 0 0.312 0.152 1.000 20 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(2), MAP2K1(1), RAF1(1) 401384 4 4 4 1 0 1 0 2 1 0 0.469 0.160 1.000 21 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(1), PLCB1(3), PRKCA(2) 401203 7 7 7 3 5 0 0 2 0 0 0.631 0.164 1.000 22 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(1) 90631 1 1 1 1 0 1 0 0 0 0 0.860 0.170 1.000 23 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 17 ARPC1B(3), NCKAP1(1), NTRK1(4) 732085 8 7 8 2 3 0 2 2 1 0 0.457 0.172 1.000 24 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT2(2), MAP2K1(1), NTRK1(4), PIK3CD(1), SOS1(1) 780886 9 7 9 2 2 0 1 3 3 0 0.573 0.179 1.000 25 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SEC61A2(1), SRP54(1), SRP68(2) 382094 5 4 5 0 2 0 1 1 1 0 0.189 0.181 1.000 26 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(2), GBA3(1), SHMT2(1) 263675 5 4 5 1 5 0 0 0 0 0 0.202 0.200 1.000 27 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(2), CD3D(1) 159157 3 2 3 1 1 1 0 0 1 0 0.446 0.200 1.000 28 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 HLA-DRA(2) 148998 2 2 2 1 2 0 0 0 0 0 0.565 0.213 1.000 29 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(1), CASP8(1), CFLAR(1) 195346 3 2 3 1 1 0 0 1 1 0 0.784 0.219 1.000 30 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(3), DAXX(2), PAX3(1), RB1(1), SP100(2), TP53(2) 921061 11 8 11 4 5 0 3 1 2 0 0.460 0.243 1.000 31 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(2), ITGA4(1), ITGAL(2), SELE(9) 577706 14 6 14 2 10 0 0 1 3 0 0.0774 0.244 1.000 32 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), BHMT(2), DNMT3B(2), MARS(3), MAT1A(2), MTAP(1), MTFMT(1), TAT(1) 1041401 13 6 13 4 8 1 1 2 1 0 0.201 0.249 1.000 33 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), EHHADH(2), HADHA(2), SDS(1) 415003 6 5 6 1 5 0 0 0 1 0 0.189 0.252 1.000 34 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1) 55390 1 1 1 1 0 0 0 0 1 0 0.873 0.261 1.000 35 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 ABP1(4), AOC2(1), CES1(5), DDHD1(3), LIPA(3), MYST3(4), MYST4(5), PLA1A(2), PNPLA3(1), PPME1(1) 1253489 29 11 29 8 17 3 2 3 4 0 0.0848 0.262 1.000 36 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(4), AOC2(1), CES1(5), ESD(1) 296797 11 6 11 2 9 1 1 0 0 0 0.0570 0.268 1.000 37 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 NFKB1(1), TP53(2) 476878 3 3 3 0 1 0 1 0 1 0 0.437 0.268 1.000 38 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(2), CRY1(2), CSNK1D(1), PER1(1), PER2(2), PER3(1) 842627 9 7 8 2 3 1 0 2 3 0 0.502 0.276 1.000 39 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCND3(1), CCNE1(1), CDKN2A(2), E2F1(1), RB1(1) 802915 6 6 6 1 3 0 0 0 3 0 0.198 0.288 1.000 40 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 EIF4EBP1(1), IGF1(1), IGF1R(4), INPPL1(1), PTEN(1), RPS6KB1(1) 969601 9 6 9 1 4 1 1 2 1 0 0.168 0.290 1.000 41 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), BAX(1), BCL2(1), CES1(5) 526714 8 6 8 2 5 1 1 0 1 0 0.369 0.292 1.000 42 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 HLA-DRA(2) 194043 2 2 2 0 2 0 0 0 0 0 0.305 0.304 1.000 43 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ANKRD1(1), EIF4EBP1(1), IL1R1(2), JUND(1), NR4A3(2) 521526 7 6 7 3 5 0 1 1 0 0 0.536 0.307 1.000 44 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(1), ACOX3(4), PLA2G2A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2) 500476 12 6 12 5 7 1 0 0 4 0 0.364 0.311 1.000 45 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(3), CD38(2), ENPP1(1), ENPP3(1), NADK(1), NADSYN1(2), NNMT(1), NT5C1B(4), NT5E(1), QPRT(1) 1057766 17 7 17 4 11 1 1 2 2 0 0.143 0.314 1.000 46 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), CAT(1), LPO(3), MPO(3), PRDX1(2), SHMT2(1), TPO(3) 587393 14 9 14 7 10 0 0 2 2 0 0.408 0.321 1.000 47 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 35575 1 1 1 0 1 0 0 0 0 0 0.608 0.322 1.000 48 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 EIF4A1(1), EIF4EBP1(1), EIF4G1(1), EIF4G2(2), EIF4G3(1), FKBP1A(1), PTEN(1), RPS6KB1(1), TSC1(1), TSC2(1) 1368303 11 8 11 2 5 1 2 2 1 0 0.190 0.344 1.000 49 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), HEMK1(1), MARS(3), MAT1A(2), METTL2B(2), METTL6(1), PAPSS1(1), PAPSS2(3), PRMT5(1), PRMT8(2), SCLY(1) 1238244 18 9 18 4 13 3 0 1 1 0 0.0446 0.362 1.000 50 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 CCNE1(1), CDKN2A(2), E2F1(1), RB1(1), SKP2(1), TP53(2) 1484464 8 8 8 3 3 0 1 0 4 0 0.505 0.362 1.000 51 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(1), GPI(2), PKLR(3) 452982 6 5 6 1 4 0 1 0 1 0 0.124 0.367 1.000 52 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 IL12A(1) 142826 1 1 1 0 0 0 0 1 0 0 0.854 0.381 1.000 53 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 CHEK2(1), TP53(2) 784020 3 3 3 1 0 1 1 0 1 0 0.760 0.384 1.000 54 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), EHHADH(2), HADHA(2), HSD17B4(1), NTAN1(1), VNN2(3) 584931 10 6 10 0 8 0 0 2 0 0 0.0183 0.388 1.000 55 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 GPR109B(3), GPR161(1), GPR171(1), GPR39(1) 480655 6 3 6 3 3 0 1 2 0 0 0.489 0.391 1.000 56 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 CAT(1), GHR(1), IGF1(1), IGF1R(4) 653384 7 5 7 1 4 1 0 2 0 0 0.216 0.392 1.000 57 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(1), HDC(2), TPH1(1) 293593 4 3 4 1 3 0 0 0 1 0 0.286 0.395 1.000 58 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT2(1), EXTL3(1), GLCE(2), HS3ST1(1), HS3ST2(1), HS3ST3A1(1), HS3ST3B1(1), HS6ST2(1), HS6ST3(2), NDST1(2), NDST3(3), NDST4(4) 998847 20 7 20 1 14 1 1 2 2 0 0.000769 0.396 1.000 59 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 EHHADH(2), HADHA(2), SDS(1) 387362 5 4 5 0 4 0 0 0 1 0 0.0867 0.397 1.000 60 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(1), FYN(1), THBS1(1) 364331 3 3 3 5 0 0 1 0 2 0 0.990 0.398 1.000 61 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(1), HMBS(1), PPOX(1), UROS(1) 376416 4 4 4 0 2 1 0 0 1 0 0.152 0.413 1.000 62 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(1), SHMT2(1) 199500 2 2 2 2 2 0 0 0 0 0 0.766 0.414 1.000 63 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 11 ARPC1B(3) 379543 3 3 3 1 2 0 1 0 0 0 0.572 0.416 1.000 64 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 IGF1R(4), IRS1(1), MAP2K1(1), RAF1(1), SOS1(1) 938594 8 6 8 1 3 1 0 4 0 0 0.230 0.421 1.000 65 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(4), BAX(1), CSNK1D(1), MAPK8(1), TP53(2) 1019939 9 6 9 3 3 1 1 1 3 0 0.667 0.421 1.000 66 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOB(1), ALDOC(1) 196835 2 2 2 1 2 0 0 0 0 0 0.669 0.427 1.000 67 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPP(1), ALPPL2(2), SPR(1) 312944 5 3 5 2 3 2 0 0 0 0 0.363 0.428 1.000 68 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), FYN(1), HLA-DRA(2), LCK(1), PTPRC(2) 431159 7 4 7 2 5 0 0 0 2 0 0.335 0.435 1.000 69 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(1), ADORA3(2), P2RY1(2) 297078 5 4 5 4 3 1 0 1 0 0 0.561 0.435 1.000 70 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(2), FUT2(1), FUT9(2), GLA(1), HEXA(1), ST3GAL1(1) 498132 8 5 8 2 5 0 0 3 0 0 0.260 0.437 1.000 71 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 39 CLOCK(2), CRY1(2), EIF4G2(2), ETV6(2), GFRA1(2), HERPUD1(1), KLF9(1), MYF6(2), NCKAP1(1), NR1D2(1), PER1(1), PER2(2), PURA(1), SF3A3(1), TUBB3(2), ZFR(1) 1795446 24 13 23 8 10 1 2 7 4 0 0.557 0.437 1.000 72 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 BCL2(1), EGFR(3), IGF1R(4), POLR2A(2), PRKCA(2), RB1(1), TEP1(2), TERT(2), TP53(2) 1393676 19 10 19 6 13 0 1 3 2 0 0.197 0.437 1.000 73 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(1), PAPSS2(3), SULT2A1(1), SUOX(2) 300728 7 3 7 1 6 1 0 0 0 0 0.158 0.443 1.000 74 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(1), IL6R(1), JAK1(1), JAK2(1), JAK3(1), PTPRU(2), STAT3(3) 750978 10 5 10 2 5 1 2 1 1 0 0.128 0.445 1.000 75 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(3) 238847 3 3 3 2 2 0 0 1 0 0 0.785 0.464 1.000 76 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA4(1), NDUFB2(1), NDUFB6(1) 348016 3 3 3 0 2 0 0 1 0 0 0.360 0.469 1.000 77 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), CREBBP(3), DFFA(1), DFFB(1), GZMA(1), PRF1(3) 525713 10 5 10 2 5 1 2 1 1 0 0.193 0.474 1.000 78 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), BHMT(2), DNMT3B(2), MARS(3), MAT1A(2) 877461 10 5 10 2 6 1 1 2 0 0 0.148 0.478 1.000 79 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PLCD1(1), PRKCA(2), TGM2(2) 247644 5 3 5 1 5 0 0 0 0 0 0.152 0.480 1.000 80 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT2(2), BRD4(2), CBL(1), CDKN2A(2), IGFBP1(1), INPPL1(1), IRS1(1), IRS4(2), PARD3(2), PIK3CD(1), PPYR1(1), PTEN(1), PTPN1(1), RAF1(1), RPS6KA2(1), RPS6KB1(1), SLC2A4(1), SORBS1(1), SOS1(1), SOS2(2) 2939426 26 15 26 9 10 2 2 5 7 0 0.380 0.488 1.000 81 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(2), F13B(1), HSD17B4(1), HSD3B1(1), HSD3B2(1) 388450 6 4 6 1 6 0 0 0 0 0 0.157 0.492 1.000 82 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(1), EGF(3), EGFR(3), MAP2K1(1), PTPRB(10), RAF1(1), SOS1(1), SPRY1(2), SPRY3(1) 1222812 23 10 23 6 17 0 2 3 1 0 0.124 0.494 1.000 83 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(2), IMPDH1(1), MTHFD2(1), POLG(1), PRPS2(1) 613397 6 4 6 1 3 0 0 2 1 0 0.253 0.500 1.000 84 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS3(1), DHRSX(1), MYST3(4), MYST4(5), PNPLA3(1) 826655 12 6 12 3 5 1 1 3 2 0 0.300 0.502 1.000 85 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), BIRC3(1), CASP8(1), DFFA(1), DFFB(1), LMNA(3), LMNB2(1), PRF1(3) 966308 12 7 12 4 4 2 2 3 1 0 0.469 0.503 1.000 86 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 11 ALAD(1), HBB(1), HMBS(1), UROS(1) 376852 4 3 4 1 2 1 0 0 1 0 0.359 0.512 1.000 87 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(2), CYP2C9(3) 98638 5 3 5 3 5 0 0 0 0 0 0.607 0.515 1.000 88 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 CPEB1(1), EGFR(3), ERBB4(6), ETS2(1), ETV6(2), FMN2(5), KRAS(3), MAP2K1(1), NOTCH1(1), NOTCH2(11), NOTCH3(4), NOTCH4(8), PIWIL1(4), PIWIL2(1), PIWIL3(3), RAF1(1), SOS1(1), SOS2(2), SPIRE2(1) 2593598 59 14 59 18 36 2 2 16 3 0 0.102 0.515 1.000 89 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 MAP2K1(1), MAP2K6(1), NFKB1(1), RB1(1), SP1(2) 942083 6 6 6 2 2 0 1 2 1 0 0.548 0.524 1.000 90 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLE(2), POLG(1), POLL(1), POLQ(2) 826792 6 5 6 2 1 1 0 2 2 0 0.597 0.525 1.000 91 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(1), E2F1(1), FBXW7(1), RB1(1) 397742 4 3 4 0 2 0 0 0 2 0 0.218 0.533 1.000 92 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 HMGCR(3), SC5DL(1) 543522 4 4 3 3 1 0 0 1 2 0 0.876 0.534 1.000 93 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ARPC1B(3), PDGFRA(4) 643294 7 5 7 1 6 0 1 0 0 0 0.185 0.537 1.000 94 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(1), CYP2E1(2), NR1I3(1), PTGS2(2) 269257 6 5 6 4 4 0 0 1 1 0 0.647 0.541 1.000 95 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNE1(1), E2F1(1), RB1(1), SKP2(1) 419911 4 4 4 0 3 0 0 0 1 0 0.152 0.558 1.000 96 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 GBA3(1), LPO(3), MPO(3), PRDX1(2), TPO(3) 476515 12 7 12 6 9 0 0 1 2 0 0.456 0.562 1.000 97 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BIRC3(1), CASP8(1), TRAF2(1) 405276 3 3 3 2 2 0 0 0 1 0 0.834 0.564 1.000 98 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 IL6(1), LDLR(3) 266317 4 3 4 3 3 0 1 0 0 0 0.741 0.564 1.000 99 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA4(1), ANXA6(1), CYP11A1(1), EDN1(2), HSD11B1(1), PLA2G4A(3), PTGDR(3), PTGER2(1), PTGFR(4), PTGIR(1), PTGS2(2) 1002943 20 6 20 6 16 1 1 0 2 0 0.0591 0.565 1.000 100 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(1), CAPNS1(1), CSNK1D(1), MAPT(1) 439505 4 3 4 2 2 0 0 0 2 0 0.684 0.566 1.000 101 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(1), E2F1(1), RB1(1), SKP2(1) 424718 4 4 4 0 3 0 0 0 1 0 0.151 0.567 1.000 102 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 HADHA(2), HSD17B4(1), PPT2(2) 420644 5 5 5 2 3 0 0 2 0 0 0.629 0.568 1.000 103 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 COPA(3), GBF1(1), GPLD1(1) 816489 5 4 5 2 2 2 0 0 1 0 0.451 0.577 1.000 104 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(1), MTFMT(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1), MTHFR(1), SHMT2(1) 941393 9 4 9 1 6 2 0 0 1 0 0.0608 0.581 1.000 105 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 CASP8(1), INSR(7), ITCH(2), MAGI1(1), MAGI2(5), RERE(4), WWP2(1) 1189734 21 9 21 4 13 4 1 2 1 0 0.0603 0.593 1.000 106 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 GNAQ(1) 294952 1 1 1 1 0 0 0 1 0 0 0.922 0.597 1.000 107 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(1), BAX(1), BCL2(1), BIRC3(1), CASP8(1), DFFA(1), DFFB(1) 670372 7 4 7 3 2 0 2 1 2 0 0.772 0.600 1.000 108 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(2), FYN(1), RELN(11) 680722 14 7 14 7 10 0 0 2 2 0 0.722 0.606 1.000 109 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(2) 575951 2 2 2 0 0 0 0 0 2 0 0.845 0.609 1.000 110 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(1), CP(1), HMBS(1), PPOX(1), UGT1A10(3), UGT1A3(1), UGT1A4(3), UGT1A5(1), UGT2B15(4), UGT2B4(2), UROS(1) 1364339 19 9 19 6 10 1 5 1 2 0 0.152 0.616 1.000 111 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 IL6(1) 298261 1 1 1 1 0 0 1 0 0 0 0.880 0.619 1.000 112 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT1(2), FUT2(1), FUT9(2) 294492 5 4 5 2 4 0 0 1 0 0 0.441 0.626 1.000 113 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(1), CYP2A13(2), CYP2A6(2), CYP2A7(1), NAT2(1), XDH(9) 399469 16 6 16 5 14 0 0 1 1 0 0.0411 0.627 1.000 114 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(2), ACTN2(5), ACTN3(2), BCAR1(1), BCR(2), CAPNS1(1), CRKL(1), FYN(1), MAP2K1(1), MAPK8(1), PTK2(2), PXN(1), RAF1(1), SOS1(1), TLN1(1), ZYX(1) 2292199 24 10 23 7 10 4 0 5 5 0 0.183 0.637 1.000 115 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 HMGCR(3), SC4MOL(1), SC5DL(1) 650120 5 5 4 4 2 0 0 1 2 0 0.886 0.640 1.000 116 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ACOX1(1), ACOX3(4), FASN(2), HADHA(2) 708001 10 6 10 1 8 0 0 0 2 0 0.0150 0.643 1.000 117 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA2(2), POLE(2), POLG(1), POLG2(1), POLL(1), POLM(1), POLQ(2), PRIM1(1), PRIM2(3), REV1(1), REV3L(2) 1992498 17 9 17 4 9 1 0 3 4 0 0.232 0.651 1.000 118 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 LDHA(1), LDHAL6B(3), MPST(1), SDS(1), SULT1B1(1), SULT1C4(1) 623945 8 4 8 2 4 0 1 0 3 0 0.197 0.665 1.000 119 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(1), UGT1A10(3), UGT1A3(1), UGT1A4(3), UGT1A5(1), UGT2B15(4), UGT2B4(2) 873035 15 8 15 7 8 0 5 1 1 0 0.417 0.668 1.000 120 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(2), ACTN2(5), ACTN3(2), BCAR1(1), CTNNA2(4), CTNNB1(1), PTK2(2), PXN(1) 927159 18 8 17 4 12 3 0 2 1 0 0.0426 0.673 1.000 121 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 KARS(1) 225603 1 1 1 1 1 0 0 0 0 0 0.893 0.683 1.000 122 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(4), ABCB11(9), ABCB4(2), ABCC3(3) 691694 18 6 18 9 14 2 0 1 1 0 0.273 0.683 1.000 123 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACOT11(2), DHRS3(1), DHRSX(1), EHHADH(2), HADHA(2), MYST3(4), MYST4(5), PNPLA3(1) 1293261 18 7 18 3 11 1 1 3 2 0 0.0527 0.695 1.000 124 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(1), GNAQ(1), PLCB1(3), TUB(1) 351655 6 5 6 4 4 0 0 2 0 0 0.796 0.700 1.000 125 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 EPHX2(1) 239591 1 1 1 0 0 0 1 0 0 0 0.751 0.707 1.000 126 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 DMC1(2), EGR1(2), FSHR(2), INHA(1), LHCGR(2), MLH1(3), MSH5(2), NCOR1(4), NRIP1(1), PGR(1), PRLR(1), PTGER2(1), ZP2(1) 1704981 23 10 23 4 15 2 0 3 3 0 0.0422 0.710 1.000 127 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC2(1), ABCG2(1), BCHE(1), CES1(5), CYP3A4(3), CYP3A5(1), UGT1A10(3), UGT1A3(1), UGT1A4(3), UGT1A5(1) 1128038 20 9 20 9 12 1 5 0 2 0 0.286 0.713 1.000 128 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1) 250456 1 1 1 1 0 0 0 1 0 0 0.946 0.715 1.000 129 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS3(1), DHRSX(1), HEMK1(1), METTL2B(2), METTL6(1), PRMT5(1), PRMT8(2) 746303 9 5 9 1 7 1 0 1 0 0 0.0586 0.718 1.000 130 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 EIF4A1(1), EIF4EBP1(1), EIF4G1(1), EIF4G2(2), EIF4G3(1), GHR(1), IRS1(1), PABPC1(1), PRKCA(2), PTEN(1), RPS6KB1(1) 1399886 13 8 13 4 6 1 1 3 2 0 0.449 0.723 1.000 131 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(1), CYP11A1(1), CYP11B2(2), CYP17A1(2), HSD11B1(1), HSD3B1(1), HSD3B2(1) 339015 9 4 9 5 8 0 0 0 1 0 0.246 0.724 1.000 132 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(6), PRKCA(2) 439742 8 5 8 2 7 0 0 1 0 0 0.272 0.725 1.000 133 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(1), EGF(3), EGFR(3), TF(1) 632797 8 6 8 6 6 0 0 0 2 0 0.838 0.728 1.000 134 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 NTRK1(4), PRKCA(2), SOS1(1) 765159 7 5 7 3 3 0 1 2 1 0 0.700 0.729 1.000 135 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(1), GABRA2(1), GABRA4(1), GABRA6(5), GPX1(1) 375591 9 5 8 5 6 1 1 1 0 0 0.624 0.734 1.000 136 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(1), LPO(3), MPO(3), MTHFR(1), SHMT2(1), TPO(3) 580769 13 7 13 5 10 0 0 2 1 0 0.213 0.743 1.000 137 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(2), EEF2(1), EIF2AK3(2), EIF2B1(2), EIF2B3(2), EIF4A1(1), EIF4EBP1(1), EIF4G1(1), EIF4G3(1), ETF1(1), GSPT2(1), KIAA0664(1), PABPC1(1), PABPC3(2), PAIP1(2) 2167856 21 12 20 6 11 1 1 1 7 0 0.248 0.744 1.000 138 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 GNAQ(1), GNAS(3), MAP2K1(1), NOX1(1), PIK3C2G(4), PLCB1(3), PRKCA(2), PTK2(2), RAF1(1), ROCK2(1) 1225769 19 9 19 7 13 0 0 5 1 0 0.414 0.744 1.000 139 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 FUT1(2), FUT2(1), FUT9(2), GLA(1), HEXA(1), ST3GAL1(1) 529142 8 5 8 4 5 0 0 3 0 0 0.566 0.748 1.000 140 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(2), DPYD(4), ENPP1(1), ENPP3(1), PANK1(1), PANK4(1) 679943 11 7 11 4 9 0 0 2 0 0 0.435 0.756 1.000 141 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), CYP11A1(1), CYP11B1(1), CYP11B2(2), CYP17A1(2), CYP21A2(2), HSD11B1(1), HSD3B1(1), HSD3B2(1) 480428 12 5 12 6 10 1 0 1 0 0 0.261 0.761 1.000 142 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), CYP11A1(1), CYP11B1(1), CYP11B2(2), CYP17A1(2), CYP21A2(2), HSD11B1(1), HSD3B1(1), HSD3B2(1) 480428 12 5 12 6 10 1 0 1 0 0 0.261 0.761 1.000 143 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA5(1), PSMA6(1), PSMD14(1), RPN2(1), UBE3A(1) 643716 6 3 6 1 4 0 0 2 0 0 0.306 0.765 1.000 144 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 CD3D(1), ITGAL(2), PRF1(3) 430073 6 3 6 3 3 1 0 0 2 0 0.404 0.769 1.000 145 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), GSS(1), NFKB1(1), NOX1(1), XDH(9) 485726 13 5 13 5 11 1 0 0 1 0 0.184 0.770 1.000 146 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 IL2RG(1), IRS1(1), JAK1(1), JAK3(1), RPS6KB1(1), STAT6(1) 733147 6 5 6 3 3 2 1 0 0 0 0.566 0.774 1.000 147 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AP2A1(1), AP2M1(1), DNM1(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), SYNJ1(2), SYNJ2(3), SYT1(2) 1048009 13 7 13 4 9 1 0 2 1 0 0.253 0.778 1.000 148 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), BCL2(1), CASP8(1), MAP2K1(1), MAPK8(1), NFKB1(1), RAF1(1), TRAF2(1) 998717 8 5 8 2 3 0 0 3 2 0 0.565 0.783 1.000 149 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1), MTHFR(1), SHMT2(1) 889881 8 3 8 2 6 2 0 0 0 0 0.202 0.784 1.000 150 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 OXCT1(1) 165729 1 1 1 0 1 0 0 0 0 0 0.655 0.790 1.000 151 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 SEC22B(1), STX16(2), STX2(2), STX3(1), VTI1A(1), VTI1B(1) 813428 8 6 8 2 6 1 0 1 0 0 0.194 0.791 1.000 152 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), BIRC3(1), CASP8(1), DFFA(1), DFFB(1), PRF1(3), SCAP(1), SREBF2(1) 904384 10 6 10 4 3 2 3 1 1 0 0.524 0.793 1.000 153 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB27A(1), RAB3A(2) 207965 3 2 3 0 3 0 0 0 0 0 0.234 0.795 1.000 154 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 BCMO1(1) 192446 1 1 1 1 1 0 0 0 0 0 0.827 0.796 1.000 155 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(3), EGFR(3), NRG1(3) 511323 9 6 9 6 8 0 0 0 1 0 0.813 0.797 1.000 156 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 KEAP1(1), MAPK8(1), PRKCA(2) 432229 4 3 4 2 3 0 0 1 0 0 0.652 0.799 1.000 157 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 GARS(1), HARS(1), IARS(2), KARS(1), LARS(2), MARS(3), NARS(1), QARS(2), RARS(2), SARS(2) 1596901 17 10 17 7 12 2 0 2 1 0 0.345 0.799 1.000 158 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 IDI2(1) 209933 1 1 1 0 1 0 0 0 0 0 0.616 0.813 1.000 159 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 IL6(1), IL6R(1), IL6ST(1), JAK1(1), JAK2(1), JAK3(1), MAP2K1(1), PTPN11(1), RAF1(1), SOS1(1), STAT3(3) 1164666 13 9 13 5 4 1 2 5 1 0 0.512 0.816 1.000 160 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG7(2), IFNA14(1), IFNA16(1), IFNA6(1), IFNA7(1), PIK3R4(2), PRKAA2(1), ULK1(1) 1030270 10 6 10 4 4 3 1 2 0 0 0.467 0.818 1.000 161 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 HADHA(2) 271079 2 2 2 0 2 0 0 0 0 0 0.394 0.822 1.000 162 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS3(1), DHRSX(1) 448293 2 2 2 1 1 0 0 1 0 0 0.770 0.823 1.000 163 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(2), FUT2(1), FUT3(1) 248200 4 2 4 3 3 1 0 0 0 0 0.625 0.824 1.000 164 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 TAT(1) 129885 1 1 1 0 1 0 0 0 0 0 0.587 0.830 1.000 165 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 MYT1(2), RB1(1), TP53(2) 863944 5 5 5 4 2 0 1 0 2 0 0.900 0.830 1.000 166 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(2), AMY2A(1), AMY2B(1), ENPP1(1), ENPP3(1), GAA(1), GBA3(1), GBE1(1), GCK(5), GPI(2), GYS1(1), GYS2(2), HK2(1), HK3(3), MGAM(12), PYGB(1), PYGM(1), SI(8), UGT1A10(3), UGT1A3(1), UGT1A4(3), UGT1A5(1), UGT2B15(4), UGT2B4(2) 2759161 59 11 58 20 41 5 6 3 4 0 0.0305 0.835 1.000 167 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 KARS(1) 337249 1 1 1 1 1 0 0 0 0 0 0.900 0.837 1.000 168 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(3), RANGAP1(1) 423652 4 3 4 2 3 0 0 0 1 0 0.796 0.846 1.000 169 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), HMGCR(3), IDI2(1), SC4MOL(1), SC5DL(1) 953380 7 5 6 5 4 0 0 1 2 0 0.798 0.852 1.000 170 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 15 ACTN1(2), ACTN2(5), ACTN3(2), CAPNS1(1), PTK2(2), PXN(1), SPTAN1(2), TLN1(1) 1369063 16 7 15 3 11 1 0 1 3 0 0.0189 0.853 1.000 171 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(1), GABRA1(1), GABRA2(1), GABRA4(1), GABRA6(5), NSF(1), UBQLN1(1) 571978 11 7 10 5 8 0 2 1 0 0 0.470 0.855 1.000 172 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), BCAT2(1), COASY(2), DPYD(4), ENPP1(1), ENPP3(1), PANK1(1), PANK4(1), VNN1(1) 843454 13 7 13 4 11 0 0 2 0 0 0.259 0.856 1.000 173 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 APAF1(1), BCL2(1), DAXX(2), FAS(1), FASLG(3), MAPKAPK3(1) 565223 9 6 9 8 5 0 1 1 2 0 0.911 0.861 1.000 174 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(4), AGTR2(1), EDN1(2), EGF(3), EGFR(3), NFKB1(1), PRKCA(2) 1014161 16 9 16 7 14 0 0 1 1 0 0.335 0.862 1.000 175 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 PTK2B(2), SOS1(1) 432481 3 2 3 2 2 0 0 1 0 0 0.796 0.864 1.000 176 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3D(1), ITGAL(2), PTPRC(2) 520205 6 3 6 4 3 0 0 0 3 0 0.604 0.865 1.000 177 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), PDE1A(3), PDE1B(2), PLCB1(3) 535603 9 7 9 5 7 0 0 2 0 0 0.630 0.873 1.000 178 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 RECK(1), TIMP2(1) 366009 2 2 2 2 1 0 0 1 0 0 0.893 0.877 1.000 179 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACSL3(1), CPT1A(3), EHHADH(2), HADHA(2) 841044 8 5 8 2 7 0 0 0 1 0 0.263 0.880 1.000 180 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3D(1), ITGAL(2), PTPRC(2) 545776 6 3 6 4 3 0 0 0 3 0 0.597 0.882 1.000 181 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), CHAT(1), SLC18A3(1) 341277 3 2 3 4 2 0 0 0 1 0 0.893 0.887 1.000 182 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(2), AXIN1(2), BTRC(1), CTNNB1(1), DLL1(1), FZD1(1), NOTCH1(1) 1031681 9 8 9 9 4 1 1 1 2 0 0.974 0.888 1.000 183 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 FLT3(2), IGF1(1), IL6(1) 406195 4 4 4 3 2 1 1 0 0 0 0.798 0.889 1.000 184 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 APAF1(1), BAX(1), BCL2(1), PRKCA(2), PTK2(2), PXN(1), TLN1(1), TP53(2) 1346512 11 7 11 6 5 0 2 1 3 0 0.752 0.892 1.000 185 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP8(1), CFLAR(1), DAXX(2), DFFA(1), DFFB(1), FAF1(1), LMNA(3), LMNB2(1), MAPK8(1), PAK2(1), PTPN13(1), RB1(1), SPTAN1(2) 2003260 17 9 17 5 6 1 1 7 2 0 0.401 0.892 1.000 186 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 LDHA(1), MPST(1) 340912 2 2 2 0 2 0 0 0 0 0 0.370 0.894 1.000 187 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 IL10RA(1), IL6(1), JAK1(1), STAT3(3) 604730 6 4 6 4 2 0 2 0 2 0 0.706 0.896 1.000 188 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(1) 162037 1 1 1 0 1 0 0 0 0 0 0.538 0.897 1.000 189 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(2), F2(1), F2R(1), FGA(3), FGB(1), PLG(1), SERPINB2(3), SERPINE1(1) 656945 13 4 13 4 9 1 0 2 1 0 0.278 0.897 1.000 190 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(1), BCL2(1), BIRC3(1), CASP8(1), CFLAR(1), DFFA(1), DFFB(1), LMNA(3), NFKB1(1), SPTAN1(2), TNFRSF10B(1), TNFRSF25(1), TNFSF10(1), TRAF2(1) 1653162 17 9 17 7 8 2 2 4 1 0 0.472 0.898 1.000 191 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 CASP8(1), DFFA(1), DFFB(1), LMNA(3), LMNB2(1), MADD(2), MAPK8(1), PAK2(1), RB1(1), SPTAN1(2), TRAF2(1) 1915550 15 8 15 6 7 1 1 4 2 0 0.499 0.899 1.000 192 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 GBA(2), GBA3(1), LPO(3), MPO(3), TPO(3) 414211 12 5 12 5 10 0 0 1 1 0 0.247 0.903 1.000 193 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3D(1), CD86(1), HLA-DRA(2), ICOS(1), ITK(3), LCK(1), PTPN11(1) 627922 10 5 10 3 8 0 0 0 2 0 0.277 0.905 1.000 194 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 INSR(7), IRS1(1), MAP2K1(1), MAPK8(1), PTPN11(1), RAF1(1), SLC2A4(1), SOS1(1) 1258977 14 8 14 4 6 3 0 5 0 0 0.290 0.910 1.000 195 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 JAK1(1), JAK2(1) 401797 2 1 2 1 1 0 0 1 0 0 0.804 0.912 1.000 196 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 IGF1(1), IGF1R(4), IRS1(1), MAP2K1(1), MAPK8(1), PTPN11(1), RAF1(1), SOS1(1) 1215093 11 7 11 4 4 2 0 5 0 0 0.528 0.914 1.000 197 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), CSF1R(3), EGF(3), EGFR(3), PDGFRA(4), PRKCA(2), SH3KBP1(1) 963036 17 8 17 9 13 1 1 0 2 0 0.573 0.915 1.000 198 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(2), BAX(1), BCL2(1), CSF2RB(1), IGF1(1), IGF1R(4), KIT(4), PRKACG(2), PRKAR1B(1) 1073268 17 8 17 9 10 1 2 3 1 0 0.590 0.915 1.000 199 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), GRIN1(1), JAK2(1), NFKB1(1) 616686 4 2 4 1 2 0 0 1 1 0 0.476 0.915 1.000 200 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 21 CCNE1(1), E2F1(1), NFKB1(1), RAF1(1), RB1(1) 969341 5 4 5 0 3 0 0 1 1 0 0.126 0.917 1.000 201 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 MAPK8(1), NFKB1(1), TNFRSF13B(1), TNFRSF17(2), TRAF2(1), TRAF6(1) 706258 7 5 7 3 6 0 0 1 0 0 0.512 0.917 1.000 202 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(1), JAK2(1), JAK3(1), PTPRU(2) 672601 5 3 5 2 3 1 0 1 0 0 0.509 0.921 1.000 203 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGAP5(1), CASP8(1), PRF1(3) 640035 6 4 6 4 2 1 1 1 1 0 0.869 0.923 1.000 204 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 GALNS(1), GLB1(2), HEXA(1), IDUA(1), LCT(3), NAGLU(1) 706868 9 3 9 4 5 1 0 1 2 0 0.484 0.925 1.000 205 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(1), CHAT(1), DBH(1), DDC(2), GAD2(1), HDC(2), SLC18A3(1), TPH1(1) 693860 10 4 10 4 7 0 1 0 2 0 0.254 0.929 1.000 206 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 BDKRB2(3), CHRM1(1), FLT1(4), FLT4(2), KDR(7), NOS3(3), PDE2A(4), PDE3A(1), PRKACG(2), PRKAR1B(1), PRKG1(1), PRKG2(3), RYR2(8), SLC7A1(1), SYT1(2) 1985593 43 13 42 18 27 3 3 9 1 0 0.175 0.930 1.000 207 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(1), CRK(1), CXCR4(1), GNAQ(1), MAP2K1(1), NFKB1(1), PIK3C2G(4), PRKCA(2), PTK2(2), PTK2B(2), PXN(1), RAF1(1) 1346767 18 10 18 7 11 1 0 5 1 0 0.414 0.931 1.000 208 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 DFFA(1), DFFB(1), TOP2A(1) 440214 3 1 3 2 1 0 1 1 0 0 0.857 0.935 1.000 209 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(2), AXIN1(2), BTRC(1), CREBBP(3), CSNK1D(1), CTNNB1(1), FZD1(1), TLE1(1), WIF1(1) 1430650 13 8 13 9 6 1 1 2 3 0 0.924 0.937 1.000 210 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 MEF2B(1), NTRK1(4) 930482 5 5 5 3 1 1 1 1 1 0 0.818 0.940 1.000 211 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(4), C6(1), C7(5), C8A(3) 603138 13 7 13 5 10 0 1 2 0 0 0.389 0.940 1.000 212 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(4), CR2(3), HLA-DRA(2), ITGAL(2), PTPRC(2) 730654 13 6 13 5 9 2 0 1 1 0 0.356 0.941 1.000 213 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(3), EPHB1(6), FYN(1), L1CAM(2), SELP(1) 777121 13 8 13 7 11 0 0 1 1 0 0.604 0.941 1.000 214 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH9A1(1), EHHADH(2), HADHA(2), SDS(1) 598729 6 5 6 5 4 1 0 0 1 0 0.738 0.941 1.000 215 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 HEMK1(1), METTL2B(2), METTL6(1), PRMT5(1), PRMT8(2) 693653 7 4 7 2 6 1 0 0 0 0 0.257 0.943 1.000 216 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 BCAR1(1), PTEN(1), PTK2(2), SOS1(1) 936660 5 4 5 2 2 1 0 2 0 0 0.725 0.944 1.000 217 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(1), ALDOC(1), G6PD(1), GPI(2), PGD(1), PRPS1L1(2), PRPS2(1), RBKS(1), TKTL2(3) 1195523 13 6 13 7 10 1 1 0 1 0 0.384 0.944 1.000 218 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP6(5), ACPP(1), ENPP1(1), ENPP3(1) 732707 8 3 8 2 6 0 1 0 1 0 0.261 0.944 1.000 219 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(1), TAT(1) 430886 2 1 2 2 1 1 0 0 0 0 0.829 0.945 1.000 220 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CAPN2(2), CAPNS1(1), EP300(2), NFATC1(1), NFATC2(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(2), SYT1(2) 1215772 16 7 16 8 13 0 0 0 3 0 0.446 0.948 1.000 221 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 MAP2K1(1), MAPK8(1), RAF1(1), SOS1(1) 936010 4 3 4 2 0 0 0 4 0 0 0.867 0.948 1.000 222 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 TPK1(1) 313212 1 1 1 0 1 0 0 0 0 0 0.665 0.949 1.000 223 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(3), EGFR(3), MAP2K1(1), RXRA(1) 840401 8 6 8 5 5 1 0 1 1 0 0.749 0.951 1.000 224 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 DUSP10(1), GAB1(1), GCK(5), IL1R1(2), MAP2K5(1), MAP2K7(1), MAP3K13(3), MAP3K2(2), MAP3K4(3), MAP3K5(1), MAP3K9(3), MAPK8(1), MAPK9(3), PAPPA(4), TP53(2), TRAF6(1) 2462122 34 13 34 12 24 2 1 4 3 0 0.272 0.951 1.000 225 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR2(1) 310841 1 1 1 0 1 0 0 0 0 0 0.651 0.953 1.000 226 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(2), TAT(1) 231486 3 1 3 1 3 0 0 0 0 0 0.483 0.953 1.000 227 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(4), ADH1A(2), ADH1B(4), ADH1C(3), ADH5(1), ADH6(2), ADH7(1), ALDH3B2(1), AOC2(1), AOX1(3), DBH(1), DDC(2), FAH(1), HEMK1(1), HGD(2), HPD(1), METTL2B(2), METTL6(1), MYST3(4), MYST4(5), PNPLA3(1), PRMT5(1), PRMT8(2), TAT(1), TPO(3) 2916663 50 12 48 20 35 3 3 6 3 0 0.104 0.955 1.000 228 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(2), CD2(1), CD3D(1), IL12A(1), IL12RB1(2), IL12RB2(1), JAK2(1), STAT4(2) 719059 11 4 11 6 6 1 0 2 2 0 0.589 0.956 1.000 229 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 JAK1(1), JAK2(1), PLA2G2A(1), PTPRU(2) 563017 5 2 5 1 4 0 0 1 0 0 0.308 0.957 1.000 230 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA5(1), PSMA6(1) 439045 3 2 3 1 3 0 0 0 0 0 0.535 0.960 1.000 231 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP6(5), ACPP(1), ALPI(1), ALPP(1), ALPPL2(2), CYP3A4(3), CYP3A5(1), DHRS3(1), DHRSX(1) 881164 16 7 16 8 10 2 1 1 2 0 0.373 0.961 1.000 232 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 DIAPH2(2), MCM2(1), MCM4(2), MCM5(1), ORC6L(1), POLA2(2), POLE(2), PRIM1(1), RFC1(1), RFC2(1), RPA2(1), UBC(1) 2500596 16 8 16 9 9 1 1 1 4 0 0.747 0.962 1.000 233 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(1), APOC1(1), CYP7A1(1), HMGCR(3), LDLR(3), LRP1(1) 1372641 10 6 9 9 7 0 0 1 2 0 0.859 0.966 1.000 234 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3D(1), IL2RA(1), TGFBR3(1) 515397 3 3 3 3 2 0 0 0 1 0 0.882 0.968 1.000 235 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 GNAS(3), NFKB1(1), NOS3(3), SYT1(2) 867153 9 5 9 4 8 0 0 0 1 0 0.463 0.968 1.000 236 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 BCL2(1), CBL(1), CFLAR(1), CRKL(1), E2F1(1), IL2RA(1), IL2RB(2), IL2RG(1), IRS1(1), JAK1(1), JAK3(1), RAF1(1), RPS6KB1(1), SOS1(1), STAT5B(1), SYK(1) 1768589 17 6 17 6 7 2 3 3 2 0 0.369 0.969 1.000 237 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 IL2RA(1), IL2RB(2), IL2RG(1), JAK1(1), JAK3(1), LCK(1), MAP2K1(1), MAPK8(1), RAF1(1), SOS1(1), STAT5B(1), SYK(1) 1132123 13 5 13 4 6 1 1 4 1 0 0.300 0.969 1.000 238 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), ASPH(1), EDN1(2), EP300(2), LDHA(1), NOS3(3), P4HB(1) 842105 11 4 11 1 9 1 0 0 1 0 0.0441 0.969 1.000 239 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 BCL2(1), BCR(2), CRKL(1), JAK2(1), MAP2K1(1), MAPK8(1), RAF1(1), SOS1(1), STAT5B(1) 1365483 10 6 10 4 2 2 0 5 1 0 0.694 0.970 1.000 240 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(1), JAK2(1), MAP2K1(1), RAF1(1), SOS1(1), STAT5B(1) 862377 6 5 6 3 2 0 0 4 0 0 0.787 0.973 1.000 241 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT2(2), PIK3CD(1), PTEN(1), PTK2B(2), SOS1(1) 1009724 7 5 7 3 3 0 0 2 2 0 0.772 0.974 1.000 242 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), HAO2(1), HYI(1), MDH1(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1) 631924 9 5 9 5 5 2 0 2 0 0 0.664 0.976 1.000 243 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ADH1A(2), ADH1B(4), ADH1C(3), ADH5(1), ADH6(2), ADH7(1), DHRS3(1), DHRSX(1), MYST3(4), MYST4(5), PNPLA3(1) 1238860 26 10 24 10 15 1 2 6 2 0 0.346 0.980 1.000 244 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K7(1), MAPK13(1), MAPK8(1), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(2), MAPK9(3), NFKB1(1), NFKBIL1(1), PIK3CD(1), SYT1(2), TRAF2(1), TRAF6(1) 1640899 20 9 20 8 12 0 0 5 3 0 0.363 0.981 1.000 245 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), HAO2(1), HYI(1), MDH1(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1) 661933 9 5 9 5 5 2 0 2 0 0 0.657 0.981 1.000 246 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(1), JAK2(1), JAK3(1), STAT3(3) 574868 6 3 6 4 2 1 1 1 1 0 0.719 0.981 1.000 247 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(1), JAK1(1), JAK2(1), JAK3(1), STAT3(3), STAT5B(1) 897630 8 4 8 4 3 1 1 1 2 0 0.570 0.982 1.000 248 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL1(1) 282171 1 1 1 0 1 0 0 0 0 0 0.557 0.982 1.000 249 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACPP(1), ENPP1(1), ENPP3(1) 472408 3 2 3 2 3 0 0 0 0 0 0.744 0.984 1.000 250 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT6(5), ST3GAL1(1), WBSCR17(1) 712719 7 3 7 4 7 0 0 0 0 0 0.570 0.984 1.000 251 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 GALNS(1), GLB1(2), HEXA(1), HPSE(1), HPSE2(1), IDUA(1), LCT(3), NAGLU(1), SPAM1(2) 1000319 13 4 13 5 8 1 0 1 3 0 0.307 0.986 1.000 252 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 NEK1(1) 341180 1 1 1 0 1 0 0 0 0 0 0.690 0.986 1.000 253 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(2), LARS(2) 498497 5 4 5 3 4 0 0 1 0 0 0.769 0.986 1.000 254 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CHIA(1), CHIT1(1), CTBS(1), GFPT1(1), GFPT2(1), HEXA(1), HK2(1), HK3(3) 1414391 11 7 11 3 6 1 1 2 1 0 0.236 0.986 1.000 255 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(2), NFATC1(1), NFATC2(3), PRKACG(2), PRKAR1B(1) 593914 9 4 9 8 8 0 0 0 1 0 0.777 0.987 1.000 256 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 BRCA1(1), BRCA2(2), CHEK2(1), FANCA(1), FANCD2(2), RAD1(1), TP53(2) 2174056 10 6 10 3 3 2 2 1 2 0 0.446 0.987 1.000 257 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(1), APAF1(1), BCL2(1), BIRC3(1), CASP8(1), CFLAR(1), DAXX(2), DFFA(1), DFFB(1), LMNA(3), LMNB2(1), MAP2K7(1), MAP3K5(1), MAPK8(1), NFKB1(1), NUMA1(1), PAK2(1), PTK2(2), RB1(1), SPTAN1(2), TRAF1(1), TRAF2(1) 3400454 27 9 27 9 14 1 2 6 4 0 0.205 0.987 1.000 258 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(3), EP300(2), ESR1(1), PELP1(1) 725687 7 4 7 3 6 0 1 0 0 0 0.510 0.987 1.000 259 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(4), MDH1(1), ME1(1), PC(2) 461229 8 4 8 5 4 2 0 2 0 0 0.659 0.987 1.000 260 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(1), EIF2B1(2), EIF2B3(2), FLT1(4), FLT4(2), KDR(7), NOS3(3), PRKCA(2), PTK2(2), PXN(1) 1685571 26 9 25 8 18 2 0 3 3 0 0.0920 0.989 1.000 261 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 MAP3K5(1), MAPK8(1), NFKB1(1), TNFSF9(1), TRAF2(1) 929655 5 4 5 2 4 0 0 1 0 0 0.570 0.989 1.000 262 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), ACE2(3), AGTR1(2), AGTR2(1), ANPEP(2), CMA1(2), CPA3(2), ENPEP(3), MME(1), NLN(1), REN(2) 1031242 21 9 21 10 13 0 2 3 3 0 0.371 0.989 1.000 263 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1B(1), GLI2(5), GLI3(3), PRKACG(2), PRKAR1B(1), SMO(3) 814528 15 5 15 9 10 2 1 1 1 0 0.616 0.989 1.000 264 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2E2(1), GTF2H1(1), GTF2H4(1), GTF2I(1), GTF2IRD1(1), TAF1(1), TAF13(1), TAF1L(5), TAF4(2), TAF7(1), TAF7L(2) 1794914 17 6 17 4 10 4 1 1 1 0 0.121 0.990 1.000 265 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(2), GNAS(3) 319689 5 2 5 3 5 0 0 0 0 0 0.605 0.990 1.000 266 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP5(1), BMP6(1), BTRC(1), CSNK1A1L(2), CSNK1D(1), FBXW11(1), GLI1(2), GLI2(5), GLI3(3), HHIP(1), LRP2(7), PRKACG(2), PRKX(1), PTCH1(1), PTCH2(3), RAB23(1), SMO(3), STK36(1), WNT10A(1), WNT10B(1), WNT16(1), WNT2(2), WNT3(1), WNT3A(1), WNT5A(1), WNT5B(1), WNT7A(3), WNT7B(2), WNT8A(1), ZIC2(1) 2954111 53 10 53 21 38 5 3 4 3 0 0.0790 0.991 1.000 267 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(1), FYN(1), MAP2K1(1), MYLK(2), PTK2(2), PXN(1), RAF1(1), TLN1(1) 1842549 10 6 10 4 4 0 0 4 2 0 0.622 0.991 1.000 268 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH4A1(1), ALDH5A1(2), CAD(2), GAD2(1), GFPT1(1), GLS2(2), GPT(1), GSS(1), NADSYN1(2), QARS(2) 1640379 15 6 15 7 11 1 2 1 0 0 0.400 0.991 1.000 269 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 GNAQ(1), NFATC1(1), NFATC2(3), NFATC4(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(2), SP1(2), SYT1(2) 1025510 15 9 15 8 10 0 1 2 2 0 0.624 0.991 1.000 270 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(1), POLR2A(2) 663293 3 2 3 2 3 0 0 0 0 0 0.686 0.992 1.000 271 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), BCAT2(1), IARS(2), IARS2(2), LARS(2), VARS(4), VARS2(1) 936866 13 8 13 7 8 2 0 2 1 0 0.646 0.992 1.000 272 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 CHST1(1), CHST4(1), FUT8(1), ST3GAL1(1) 616445 4 2 4 1 4 0 0 0 0 0 0.282 0.993 1.000 273 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 MUSK(1), PTK2(2), PTK2B(2), TERT(2) 804412 7 5 7 3 6 0 0 1 0 0 0.411 0.993 1.000 274 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(3), GNAS(3), IGF1R(4), MAP2K1(1), MKNK2(1), PDGFRA(4), PTPRR(2), RAF1(1), SOS1(1), STAT3(3) 1618738 23 8 23 4 17 0 1 4 1 0 0.0222 0.994 1.000 275 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(2), CDH1(1), CREBBP(3), EP300(2), MAP2K1(1) 1263237 9 6 9 7 6 0 1 1 1 0 0.916 0.994 1.000 276 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(1), PIGB(1), PIGU(2) 1180674 4 4 4 3 2 0 0 1 1 0 0.860 0.995 1.000 277 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 FUT8(1), ST3GAL1(1) 389551 2 1 2 1 2 0 0 0 0 0 0.647 0.995 1.000 278 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACPP(1), ALPI(1), ALPP(1), ALPPL2(2), CYP19A1(3), CYP1A1(3), CYP1A2(1), CYP2A13(2), CYP2A6(2), CYP2A7(1), CYP2B6(3), CYP2C18(2), CYP2C19(2), CYP2C8(2), CYP2C9(3), CYP2E1(2), CYP2F1(1), CYP3A4(3), CYP3A5(1), CYP4B1(1), CYP4F8(1) 1422797 38 10 38 14 30 2 0 1 5 0 0.0215 0.996 1.000 279 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(2), ALDH7A1(2), ALDH9A1(1), CYP2C19(2), CYP2C9(3), DHRS3(1), DHRSX(1), EHHADH(2), HADHA(2), MYST3(4), MYST4(5), PNPLA3(1) 1535653 26 9 26 10 18 2 1 3 2 0 0.222 0.997 1.000 280 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 FUT1(2), FUT2(1), FUT3(1), FUT9(2) 787845 6 4 6 4 4 1 0 1 0 0 0.667 0.997 1.000 281 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA5(1), PSMA6(1) 801617 3 2 3 0 3 0 0 0 0 0 0.239 0.997 1.000 282 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ABP1(4), ALDH9A1(1), AOC2(1), AOX1(3), ASMT(1), CAT(1), CYP19A1(3), CYP1A1(3), CYP1A2(1), CYP2A13(2), CYP2A6(2), CYP2A7(1), CYP2B6(3), CYP2C18(2), CYP2C19(2), CYP2C8(2), CYP2C9(3), CYP2E1(2), CYP2F1(1), CYP3A4(3), CYP3A5(1), CYP4B1(1), CYP4F8(1), DDC(2), EHHADH(2), HADHA(2), KYNU(1), SDS(1), TDO2(1), TPH1(1) 2688671 54 13 54 22 45 1 0 2 6 0 0.0330 0.998 1.000 283 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 GCK(5), GFPT1(1), HEXA(1), HK2(1), HK3(3) 841804 11 3 11 4 9 0 1 1 0 0 0.333 0.998 1.000 284 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 DGKA(1), ITPR1(1), ITPR2(1), ITPR3(1), MAP2K1(1), NR1I3(1), PDE3A(1), PI3(2), PIK3C2G(4), PIK3CD(1), RIPK3(2) 2375117 16 7 16 5 8 2 0 4 2 0 0.243 0.998 1.000 285 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(2), PRKACG(2) 498433 4 2 4 2 4 0 0 0 0 0 0.593 0.998 1.000 286 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 CA1(1), CA12(1), CA2(3), CA9(1), GLS2(2) 927548 8 5 8 5 6 0 1 0 1 0 0.644 0.999 1.000 287 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(1), ALDOC(1), GPT(1), MDH1(1), ME1(1), PKLR(3), PKM2(1) 893423 9 6 9 7 7 1 0 0 1 0 0.674 0.999 1.000 288 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F11(1), F12(1), F13B(1), F2(1), F7(1), F8(2), F9(1), FGA(3), FGB(1), LPA(3), PLG(1), SERPINB2(3), SERPINE1(1), SERPINF2(2), VWF(6) 1722600 28 6 28 10 18 2 2 2 4 0 0.214 0.999 1.000 289 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 UBE2J2(2), UBE3A(1) 523670 3 2 3 2 3 0 0 0 0 0 0.757 0.999 1.000 290 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 HDAC5(1), IGF1(1), IGF1R(4), INSR(7), MAP2K6(1), MEF2B(1), NFATC1(1), NFATC2(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), SYT1(2) 1720199 24 10 24 10 15 4 0 3 2 0 0.218 0.999 1.000 291 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(3), EP300(2), NCOA1(1), PPARG(2), RXRA(1) 921235 9 5 9 4 7 1 1 0 0 0 0.556 0.999 1.000 292 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(5), HK2(1), HK3(3) 506948 9 3 9 4 9 0 0 0 0 0 0.365 0.999 1.000 293 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(1), F2R(1), MAP2K1(1), PLA2G4A(3), PLCB1(3), PRKCA(2), PTK2(2), RAF1(1), SYK(1) 1195049 15 8 15 9 8 1 1 4 1 0 0.818 0.999 1.000 294 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC3(1), CASP8(1), CFLAR(1), NFKB1(1), NFKBIL1(1), TRAF2(1) 1334347 6 4 6 5 4 0 0 1 1 0 0.921 0.999 1.000 295 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 BRCA1(1), CHEK2(1), MAPK8(1), NFKB1(1), TP53(2) 1456518 6 6 6 5 2 1 1 1 1 0 0.946 0.999 1.000 296 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK2A(1), CAMK4(1), HDAC5(1), MEF2B(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), SLC2A4(1), SYT1(2) 985509 10 5 10 6 6 1 1 1 1 0 0.602 0.999 1.000 297 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 APC(2), AR(1), CCL15(2), CCL16(1), EGFR(3), GNA11(3), GNAQ(1), ITPR1(1), ITPR2(1), ITPR3(1), KCNJ5(1), PIK3CD(1), RAF1(1) 2597219 19 11 18 9 11 0 0 5 3 0 0.587 0.999 1.000 298 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 27 BCAR1(1), CRKL(1), GNAQ(1), MAP2K1(1), MAPK8(1), PRKCA(2), PTK2B(2), RAF1(1), SOS1(1), SYT1(2) 1373431 13 8 13 9 6 1 0 5 1 0 0.909 0.999 1.000 299 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASRGL1(1), CA1(1), CA12(1), CA13(1), CA2(3), CA9(1), GLS2(2) 1038667 10 5 10 6 8 0 1 0 1 0 0.605 0.999 1.000 300 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ALDH5A1(2), ALDH9A1(1), EHHADH(2), GAD2(1), HADHA(2), OXCT1(1), SDS(1) 1282638 11 6 11 8 7 2 1 0 1 0 0.719 1.000 1.000 301 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 JAK2(1), MAP2K1(1), PRKCA(2), RAF1(1), SOS1(1), STAT3(3), STAT5B(1), THPO(1) 1466168 11 6 11 4 5 0 1 4 1 0 0.501 1.000 1.000 302 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(5), HK2(1), HK3(3) 576963 9 3 9 4 9 0 0 0 0 0 0.351 1.000 1.000 303 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 CREB5(2), DUSP10(1), IL1R1(2), MAP2K6(1), MAP3K4(3), MAP3K5(1), MAPK13(1), MKNK2(1), NFKB1(1), TRAF6(1) 1633528 14 8 14 9 11 1 0 1 1 0 0.741 1.000 1.000 304 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GHR(1), INSR(7), IRS1(1), JAK2(1), MAP2K1(1), PRKCA(2), RAF1(1), SLC2A4(1), SOS1(1), STAT5B(1) 1630487 17 9 17 9 8 3 0 6 0 0 0.655 1.000 1.000 305 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(1), COX15(1), CP(1), HMBS(1), PPOX(1), UGT1A10(3), UGT1A3(1), UGT1A4(3), UGT1A5(1), UGT2B10(1), UGT2B11(1), UGT2B15(4), UGT2B28(2), UGT2B4(2), UGT2B7(1), UROS(1) 2060078 25 9 25 11 15 1 5 1 3 0 0.303 1.000 1.000 306 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(3), SCAP(1), SREBF2(1) 588926 5 3 5 3 3 1 1 0 0 0 0.622 1.000 1.000 307 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(1), HLA-DRA(2), IL12A(1), IL12RB1(2), IL12RB2(1), IL18R1(1), IL2RA(1) 624707 9 4 9 4 8 0 0 1 0 0 0.455 1.000 1.000 308 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 CAD(2), CANT1(1), CTPS2(2), DPYD(4), ENTPD1(2), ENTPD3(1), ENTPD5(1), ENTPD6(1), NT5C1B(4), NT5E(1), POLA2(2), POLE(2), POLR1A(2), POLR1B(1), POLR2A(2), POLR3A(2), POLR3K(1), PRIM1(1), PRIM2(3), TXNRD2(1), UPP2(1) 3999073 37 12 37 16 27 1 1 5 3 0 0.331 1.000 1.000 309 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(2), POLR1B(1), POLR2A(2), POLR3A(2), POLR3K(1) 1162988 8 4 8 3 5 1 0 2 0 0 0.445 1.000 1.000 310 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ALDH9A1(1), AOX1(3), BCAT1(1), BCKDHB(1), EHHADH(2), HADHA(2), HIBADH(1), IVD(1), OXCT1(1), PCCB(1), SDS(1) 1780842 16 9 16 9 10 1 0 3 2 0 0.660 1.000 1.000 311 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(4), ALDH3B2(1), AOC2(1), DDC(2), HPD(1), LPO(3), MPO(3), MYST3(4), MYST4(5), PNPLA3(1), TAT(1), TPO(3) 1692936 29 8 29 13 21 1 1 3 3 0 0.242 1.000 1.000 312 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 38 DAXX(2), HMGN1(1), MAP2K6(1), MAP3K5(1), MAP3K9(3), MEF2B(1), PLA2G4A(3), TRAF2(1) 1756977 13 5 13 6 7 4 0 1 1 0 0.682 1.000 1.000 313 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 AKT2(2), GNAQ(1), ITPR1(1), ITPR2(1), ITPR3(1), NFKB1(1), NFKBIL1(1), PIK3CB(2), PLD2(1), PLD3(1) 2201880 12 6 12 9 6 0 0 3 3 0 0.861 1.000 1.000 314 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 CREB5(2), CREBBP(3), CRKL(1), EGR1(2), EGR4(1), GNAQ(1), MAP1B(3), MAP2K7(1), MAPK8(1), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(2), MAPK9(3), NTRK1(4), OPN1LW(1), PIK3C2G(4), PIK3CD(1), PTPN11(1) 2514027 36 12 36 15 17 2 3 7 7 0 0.486 1.000 1.000 315 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 BRCA1(1), CHEK2(1), EP300(2), MYT1(2), TP53(2) 2071196 8 6 8 6 5 1 1 0 1 0 0.890 1.000 1.000 316 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ALDH9A1(1), EHHADH(2), HADHA(2), LDHA(1), MLYCD(1), PCCB(1), SDS(1), SUCLG2(1) 1639933 10 8 10 9 8 1 0 0 1 0 0.882 1.000 1.000 317 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(1), ALDOC(1), G6PD(1), GPI(2), PGD(1), PRPS1L1(2), PRPS2(1), RBKS(1) 1010276 10 6 10 8 7 1 1 0 1 0 0.717 1.000 1.000 318 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 JAK2(1), MAP2K1(1), MAPK8(1), RAF1(1), SOS1(1), STAT5B(1) 1049581 6 4 6 4 1 0 0 5 0 0 0.910 1.000 1.000 319 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 IKBKAP(1), NFKB1(1), TRAF1(1), TRAF2(1) 1092341 4 3 4 6 2 0 0 1 1 0 0.977 1.000 1.000 320 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 MAP2K6(1), MAP4K2(1), MAPK8(1), NFKB1(1), TRAF2(1) 1163348 5 4 5 6 3 0 0 1 1 0 0.942 1.000 1.000 321 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 GTF2E2(1), GTF2H1(1), GTF2H4(1), POLR1A(2), POLR1B(1), POLR2A(2), POLR3K(1), TAF13(1), TAF7(1) 1740273 11 5 11 6 6 2 1 1 1 0 0.615 1.000 1.000 322 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 RPL14(1), RPL27A(1), RPL7(1), RPS2(1), RPS29(1), RPS3A(1), RPSA(1) 1115863 7 4 7 5 4 0 1 1 1 0 0.755 1.000 1.000 323 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 AP2A1(1), AP2M1(1), BTK(3), EEA1(1), PRKCZ(1), RPS6KB1(1) 1192504 8 6 8 6 5 1 1 0 1 0 0.685 1.000 1.000 324 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 26 AKT2(2), BCL2(1), IRS1(1), JAK1(1), JAK3(1), PIK3CD(1), RAF1(1), SOS1(1), SOS2(2), STAT6(1) 1793011 12 6 12 6 5 2 0 3 2 0 0.728 1.000 1.000 325 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(4), ALDH3B2(1), AOC2(1), DDC(2), HPD(1), LPO(3), MPO(3), PRDX1(2), TAT(1), TPO(3) 1080155 21 8 21 11 18 0 0 1 2 0 0.264 1.000 1.000 326 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 MYLK(2), NCF2(1), PDGFRA(4), RPS6KB1(1), VAV1(3) 1698883 11 7 11 9 9 0 1 0 1 0 0.875 1.000 1.000 327 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 CD74(1), CD8B(1), CIITA(1), HLA-B(1), HLA-DPB1(1), HLA-DQA1(2), HLA-DQB1(1), HLA-DRA(2), HSP90AA1(1), HSP90AB1(1), IFNA14(1), IFNA16(1), IFNA6(1), IFNA7(1), KIR2DL1(4), KIR2DL3(2), KIR2DL4(1), KIR2DS4(4), KIR3DL1(4), KLRC2(1), KLRD1(1), PDIA3(1), PSME2(1), TAP2(1) 2275377 36 8 36 15 26 4 2 3 1 0 0.115 1.000 1.000 328 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(1), G6PC2(1), GAA(1), GCK(5), GLA(1), GLB1(2), HK2(1), HK3(3), LCT(3), MGAM(12) 1886568 30 8 30 14 24 3 0 3 0 0 0.206 1.000 1.000 329 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(1), BAI1(1), BAX(1), CASP8(1), CCNB3(3), CCND3(1), CCNE1(1), CCNE2(3), CDKN2A(2), CHEK2(1), EI24(1), FAS(1), GTSE1(2), IGF1(1), PERP(1), PTEN(1), SERPINB5(2), SERPINE1(1), STEAP3(1), THBS1(1), TNFRSF10B(1), TP53(2), TSC2(1) 3185108 31 16 30 11 10 4 3 7 7 0 0.336 1.000 1.000 330 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(3), E2F1(1), ETS2(1), HDAC5(1), SIN3A(1) 1286104 7 5 7 6 3 1 0 2 1 0 0.891 1.000 1.000 331 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(4), ALDH3B2(1), ALDH7A1(2), ALDH9A1(1), AOC2(1), CNDP1(2), DDC(2), HARS(1), HARS2(1), HDC(2), HEMK1(1), HNMT(1), METTL2B(2), METTL6(1), PRMT5(1), PRMT8(2), PRPS2(1), UROC1(2) 1949559 28 7 28 12 22 2 0 2 2 0 0.120 1.000 1.000 332 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 JAK1(1), MAP2K1(1), MAPK8(1), PDGFRA(4), PRKCA(2), RAF1(1), SOS1(1), STAT3(3) 1705797 14 7 14 6 8 0 1 4 1 0 0.509 1.000 1.000 333 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(1), CREBBP(3), EP300(2), ESR1(1), GRIP1(2), HDAC3(1), HDAC4(2), HDAC5(1), NRIP1(1), PELP1(1), POLR2A(2) 2242208 17 7 17 9 13 0 1 3 0 0 0.590 1.000 1.000 334 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(4), ADH1A(2), ADH1B(4), ADH1C(3), ADH6(2), ADH7(1), ALDH3B2(1), AOC2(1), AOX1(3), DBH(1), DDC(2), FAH(1), HGD(2), HPD(1), TAT(1), TPO(3) 1547722 32 10 30 16 25 1 2 3 1 0 0.245 1.000 1.000 335 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(2), ITGAV(2), PDGFRA(4), PLCB1(3), PRKCA(2), PTK2(2) 1335449 15 7 15 7 13 0 0 2 0 0 0.453 1.000 1.000 336 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 ADSL(2), AGXT2(2), CAD(2), CRAT(1), GAD2(1), GPT(1), NARS(1), PC(2) 1295340 12 4 12 7 9 1 1 1 0 0 0.523 1.000 1.000 337 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(2), ANAPC5(2), ANAPC7(1), BTRC(1), CDC27(1), CUL3(1), FBXW11(1), FBXW7(1), FZR1(1), ITCH(2), SKP2(1), WWP2(1) 1962809 15 10 15 9 9 0 0 4 2 0 0.873 1.000 1.000 338 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 FPR1(4), MAP2K1(1), MAP2K6(1), NCF2(1), NFATC1(1), NFATC2(3), NFATC4(1), NFKB1(1), PIK3C2G(4), PLCB1(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), RAF1(1), SYT1(2) 1845151 26 10 26 11 19 0 0 3 4 0 0.309 1.000 1.000 339 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(4), ADH1C(3), ADH5(1), ADH6(2), ADH7(1), AGPAT1(2), AGPAT4(1), AKR1A1(1), AKR1B1(1), ALDH7A1(2), ALDH9A1(1), CEL(1), DGAT2(3), DGKA(1), DGKB(3), DGKD(2), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), GK(1), GK2(2), GLA(1), GLB1(2), LCT(3), LIPA(3), LIPF(4), LIPG(1), PNLIPRP1(2), PNLIPRP2(1), PNPLA3(1), PPAP2C(1) 2897133 60 16 58 28 41 5 3 8 3 0 0.222 1.000 1.000 340 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ABP1(4), ALDH7A1(2), ALDH9A1(1), AOC2(1), AOX1(3), ASMT(1), CAT(1), CYP1A1(3), CYP1A2(1), DDC(2), EHHADH(2), HADHA(2), HEMK1(1), HSD17B4(1), INMT(1), KYNU(1), LNX1(1), METTL2B(2), METTL6(1), OGDH(2), OGDHL(4), PRMT5(1), PRMT8(2), TDO2(1), TPH1(1) 2981115 42 10 42 19 39 2 0 1 0 0 0.120 1.000 1.000 341 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 32 AGTR1(2), EGFR(3), GNAQ(1), MAP2K1(1), MAPK8(1), MEF2B(1), PRKCA(2), PTK2(2), PTK2B(2), RAF1(1), SOS1(1), SYT1(2) 1617222 19 8 19 9 12 1 0 6 0 0 0.599 1.000 1.000 342 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 83 DAXX(2), MAP2K1(1), MAP2K5(1), MAP2K6(1), MAP2K7(1), MAP3K13(3), MAP3K2(2), MAP3K4(3), MAP3K5(1), MAP3K6(2), MAP3K9(3), MAP4K2(1), MAP4K3(1), MAPK13(1), MAPK8(1), MAPK9(3), MAPKAPK3(1), MEF2B(1), MKNK2(1), NFKB1(1), PAK2(1), RAF1(1), RPS6KA2(1), RPS6KA4(2), RPS6KB1(1), SP1(2), TRAF2(1) 4598981 40 14 40 17 24 4 2 7 3 0 0.350 1.000 1.000 343 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 68 AKT2(2), KDR(7), KRAS(3), MAP2K1(1), MAPK13(1), MAPKAPK3(1), NFATC1(1), NFATC2(3), NFATC4(1), NOS3(3), PIK3CB(2), PIK3CD(1), PIK3R2(1), PLA2G2A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCG2(2), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRKCA(2), PRKCG(1), PTGS2(2), PTK2(2), PXN(1), RAF1(1) 3527959 49 13 49 22 30 2 2 6 9 0 0.346 1.000 1.000 344 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(1), ABCA10(1), ABCA12(7), ABCA13(11), ABCA2(1), ABCA3(4), ABCA4(4), ABCA5(2), ABCA6(3), ABCA7(1), ABCA8(2), ABCA9(2), ABCB1(4), ABCB11(9), ABCB4(2), ABCB5(7), ABCC10(1), ABCC11(4), ABCC12(3), ABCC2(1), ABCC3(3), ABCC4(1), ABCC6(2), ABCC8(7), ABCC9(7), ABCD2(3), ABCG2(1), ABCG4(1), ABCG5(5), ABCG8(4), CFTR(4), TAP2(1) 5736751 109 13 109 44 78 9 3 10 9 0 0.00402 1.000 1.000 345 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACTG1(1), ACTN1(2), ACTN2(5), ACTN3(2), ACVR1C(2), CDH1(1), CREBBP(3), CTNNA2(4), CTNNA3(4), CTNNB1(1), CTNND1(1), EGFR(3), EP300(2), FYN(1), IGF1R(4), INSR(7), IQGAP1(1), MLLT4(4), PARD3(2), PTPN1(1), PTPRB(10), PTPRF(2), SNAI2(1), SORBS1(1), SSX2IP(1), TCF7(1), TCF7L1(1), TCF7L2(2), WAS(1), YES1(1) 5886815 72 17 71 28 53 4 4 6 5 0 0.0935 1.000 1.000 346 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(1), ADORA1(1), ADORA3(2), ADRA1A(1), AGTR1(2), AGTR2(1), BDKRB2(3), BRS3(2), C5AR1(2), CALCR(2), CHRM1(1), CHRM2(1), CHRM3(2), CHRM4(1), CHRM5(1), CRHR1(1), DRD2(2), DRD5(3), F2(1), F2R(1), F2RL1(2), FPR1(4), FSHR(2), GABBR1(1), GABBR2(1), GABRA1(1), GABRA2(1), GABRA4(1), GABRA6(5), GABRB1(1), GABRB2(3), GABRD(1), GABRE(2), GABRG1(2), GABRG2(1), GABRQ(1), GABRR1(2), GH2(1), GHR(1), GHRHR(1), GLP1R(2), GLRA1(4), GLRA2(1), GLRB(2), GPR156(1), GPR50(1), GPR63(1), GRIA1(5), GRIA2(1), GRIA4(2), GRID1(2), GRID2(2), GRIK2(1), GRIK3(3), GRIK4(1), GRIN1(1), GRIN2A(7), GRIN2B(3), GRIN3A(4), GRIN3B(1), GRM1(2), GRM3(4), GRM4(1), GRM5(1), GRM6(2), GRM7(3), GRM8(7), GZMA(1), HCRTR2(1), HRH1(1), HTR1A(1), HTR1E(1), HTR2A(1), HTR5A(1), LEPR(3), LHCGR(2), MC3R(1), MC5R(1), MTNR1B(1), NMUR1(1), NMUR2(2), NPBWR2(2), NPY1R(4), NPY2R(3), NPY5R(4), NTSR1(1), NTSR2(1), OPRK1(3), OPRM1(2), P2RX3(1), P2RX5(2), P2RX7(1), P2RY1(2), P2RY10(1), PARD3(2), PPYR1(1), PRLR(1), PRSS1(3), PTGDR(3), PTGER2(1), PTGFR(4), PTGIR(1), PTH2R(1), SSTR3(1), TAAR2(1), TAAR6(1), TAAR8(1), TACR1(1), TACR2(2), TACR3(1), TBXA2R(1), TRHR(1), VIPR2(1) 10744583 203 25 201 145 135 19 9 23 17 0 0.389 1.000 1.000 347 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 246 ACVR1C(2), AKT2(2), ARRB2(1), ATF4(1), CACNA1A(3), CACNA1B(4), CACNA1C(5), CACNA1D(2), CACNA1E(9), CACNA1F(1), CACNA1G(3), CACNA1H(1), CACNA1I(4), CACNA1S(3), CACNA2D1(3), CACNA2D3(3), CACNA2D4(2), CACNB2(2), CACNG2(1), CACNG3(3), CACNG5(1), CACNG7(1), CD14(1), CRK(1), CRKL(1), DAXX(2), DUSP10(1), EGF(3), EGFR(3), FAS(1), FASLG(3), FGF11(1), FGF12(1), FGF14(1), FGF4(1), FGF5(1), FGFR2(5), FGFR3(1), FLNA(1), FLNB(7), FLNC(4), IL1R1(2), IL1R2(1), JUND(1), KRAS(3), MAP2K1(1), MAP2K5(1), MAP2K6(1), MAP2K7(1), MAP3K13(3), MAP3K2(2), MAP3K4(3), MAP3K5(1), MAP3K6(2), MAP4K2(1), MAP4K3(1), MAPK13(1), MAPK8(1), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(2), MAPK9(3), MAPKAPK3(1), MAPT(1), MKNK2(1), MOS(2), NFATC2(3), NFATC4(1), NFKB1(1), NTRK1(4), NTRK2(1), PAK2(1), PDGFRA(4), PLA2G2A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRKACG(2), PRKCA(2), PRKCG(1), PRKX(1), PTPRR(2), RAF1(1), RAPGEF2(2), RASA2(2), RASGRF2(1), RASGRP1(1), RASGRP3(2), RPS6KA2(1), RPS6KA4(2), RPS6KA6(2), SOS1(1), SOS2(2), TAOK1(1), TAOK2(3), TAOK3(1), TP53(2), TRAF2(1), TRAF6(1) 13812674 197 23 197 125 138 7 11 20 21 0 0.815 1.000 1.000 348 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 AMHR2(4), BMPR2(1), CCL14(1), CCL15(2), CCL16(1), CCL7(1), CCR1(2), CCR5(2), CCR8(1), CCR9(1), CSF1R(3), CSF2RA(1), CSF2RB(1), CX3CR1(1), CXCR4(1), CXCR6(1), EGF(3), EGFR(3), FAS(1), FASLG(3), FLT1(4), FLT3(2), FLT4(2), GDF5(2), GH2(1), GHR(1), HGF(3), IFNA14(1), IFNA16(1), IFNA6(1), IFNA7(1), IFNAR2(1), IL10RA(1), IL12A(1), IL12RB1(2), IL12RB2(1), IL17RB(1), IL18R1(1), IL18RAP(1), IL1R1(2), IL1R2(1), IL1RAP(1), IL20(1), IL20RA(1), IL21(1), IL21R(3), IL23R(1), IL25(1), IL26(1), IL28RA(1), IL2RA(1), IL2RB(2), IL2RG(1), IL5RA(1), IL6(1), IL6R(1), IL6ST(1), IL7R(3), IL9R(1), INHBA(1), INHBC(2), KDR(7), KIT(4), LEPR(3), LIFR(4), OSMR(7), PDGFC(2), PDGFRA(4), PLEKHO2(1), PRLR(1), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11B(1), TNFRSF13B(1), TNFRSF17(2), TNFRSF21(1), TNFRSF25(1), TNFRSF8(3), TNFSF10(1), TNFSF14(1), TNFSF15(1), TNFSF9(1), TPO(3), XCR1(1) 8693843 144 23 144 93 97 12 5 14 16 0 0.806 1.000 1.000 349 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 191 ACTG1(1), ACTN1(2), ACTN2(5), ACTN3(2), AKT2(2), ARHGAP5(1), BCAR1(1), BCL2(1), BIRC3(1), CAPN2(2), CCND3(1), COL11A1(6), COL11A2(6), COL1A1(6), COL1A2(4), COL2A1(6), COL3A1(6), COL4A2(2), COL4A4(10), COL4A6(2), COL5A1(6), COL5A3(8), COL6A1(2), COL6A2(1), COL6A3(7), COL6A6(5), CRK(1), CRKL(1), CTNNB1(1), EGF(3), EGFR(3), FLNA(1), FLNB(7), FLNC(4), FLT1(4), FN1(2), FYN(1), GRLF1(1), HGF(3), IGF1(1), IGF1R(4), ITGA10(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA6(1), ITGA7(3), ITGA8(4), ITGAV(2), ITGB4(4), ITGB5(2), ITGB6(3), ITGB8(1), KDR(7), LAMA1(3), LAMA2(4), LAMA3(1), LAMA4(1), LAMA5(4), LAMB2(2), LAMB3(2), LAMB4(1), LAMC2(1), MAP2K1(1), MAPK8(1), MAPK9(3), MYLK(2), MYLK2(3), PAK2(1), PAK3(1), PAK7(1), PDGFC(2), PDGFD(1), PDGFRA(4), PIK3CB(2), PIK3CD(1), PIK3R2(1), PIP5K1C(1), PRKCA(2), PRKCG(1), PTEN(1), PTK2(2), PXN(1), RAF1(1), RELN(11), ROCK2(1), SHC3(1), SOS1(1), SOS2(2), THBS1(1), THBS3(1), THBS4(2), TLN1(1), TNC(5), TNN(4), TNR(8), TNXB(17), VAV1(3), VWF(6), ZYX(1) 18201587 281 23 280 132 206 13 5 31 25 1 0.240 1.000 1.000 350 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(2), ADCY2(1), ADCY7(3), ADCY8(1), ADCY9(2), ADRA1A(1), ADRA1D(1), AGTR1(2), ATP2A1(2), ATP2A2(1), ATP2A3(3), ATP2B1(1), ATP2B2(3), ATP2B3(1), BDKRB2(3), CACNA1A(3), CACNA1B(4), CACNA1C(5), CACNA1D(2), CACNA1E(9), CACNA1F(1), CACNA1G(3), CACNA1H(1), CACNA1I(4), CACNA1S(3), CAMK2A(1), CAMK4(1), CD38(2), CHRM1(1), CHRM2(1), CHRM3(2), CHRM5(1), EGFR(3), ERBB4(6), F2R(1), GNA11(3), GNAQ(1), GNAS(3), GRIN1(1), GRIN2A(7), GRM1(2), GRM5(1), HRH1(1), HTR2A(1), HTR5A(1), ITPR1(1), ITPR2(1), ITPR3(1), LHCGR(2), MYLK(2), MYLK2(3), NOS1(3), NOS3(3), NTSR1(1), P2RX3(1), P2RX5(2), P2RX7(1), PDE1A(3), PDE1B(2), PDE1C(4), PDGFRA(4), PHKA1(3), PHKB(1), PLCB1(3), PLCB3(1), PLCB4(9), PLCD1(1), PLCE1(3), PLCG2(2), PLCZ1(2), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRKACG(2), PRKCA(2), PRKCG(1), PRKX(1), PTGFR(4), PTK2B(2), RYR1(11), RYR2(8), RYR3(7), SLC8A1(2), SLC8A2(1), SLC8A3(5), TACR1(1), TACR2(2), TACR3(1), TBXA2R(1), TRHR(1), TRPC1(1) 13004097 218 22 216 143 155 12 11 25 14 1 0.369 1.000 1.000 351 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(2), ADCY2(1), ADCY5(3), ADCY7(3), ADCY8(1), ADCY9(2), CSNK1D(1), DRD2(2), EGF(3), EGFR(3), GJA1(1), GNA11(3), GNAQ(1), GNAS(3), GRM1(2), GRM5(1), GUCY1A3(4), GUCY1B3(2), GUCY2C(3), GUCY2D(1), GUCY2F(1), HTR2A(1), ITPR1(1), ITPR2(1), ITPR3(1), KRAS(3), MAP2K1(1), MAP2K5(1), MAP3K2(2), NPR1(1), NPR2(1), PDGFC(2), PDGFD(1), PDGFRA(4), PLCB1(3), PLCB3(1), PLCB4(9), PRKACG(2), PRKCA(2), PRKCG(1), PRKG1(1), PRKG2(3), PRKX(1), RAF1(1), SOS1(1), SOS2(2), TUBA1A(1), TUBA1B(4), TUBA3C(1), TUBA3E(1), TUBA4A(1), TUBB3(2), TUBB4Q(2), TUBB6(2), TUBB8(2) 6433006 106 22 102 61 67 6 7 19 7 0 0.459 1.000 1.000 352 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 202 ACTN1(2), ACTN2(5), ACTN3(2), APC(2), APC2(1), ARHGEF6(3), ARHGEF7(1), ARPC1B(3), BCAR1(1), BDKRB2(3), CD14(1), CHRM1(1), CHRM2(1), CHRM3(2), CHRM4(1), CHRM5(1), CRK(1), CRKL(1), CYFIP1(3), CYFIP2(2), DIAPH2(2), EGF(3), EGFR(3), F2(1), F2R(1), FGD3(2), FGF11(1), FGF12(1), FGF14(1), FGF4(1), FGF5(1), FGFR2(5), FGFR3(1), FN1(2), GNA13(1), GRLF1(1), IQGAP1(1), IQGAP2(2), IQGAP3(2), ITGA10(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA6(1), ITGA7(3), ITGA8(4), ITGAD(1), ITGAE(1), ITGAL(2), ITGAM(3), ITGAV(2), ITGAX(1), ITGB4(4), ITGB5(2), ITGB6(3), ITGB8(1), KRAS(3), LIMK2(2), MAP2K1(1), MOS(2), MYH10(2), MYH14(2), MYLK(2), MYLK2(3), NCKAP1(1), NCKAP1L(3), PAK2(1), PAK3(1), PAK7(1), PDGFRA(4), PIK3CB(2), PIK3CD(1), PIK3R2(1), PIP4K2A(1), PIP5K1A(2), PIP5K1B(1), PIP5K1C(1), PTK2(2), PXN(1), RAF1(1), ROCK2(1), SOS1(1), SOS2(2), SSH1(2), SSH2(2), TIAM1(6), TIAM2(4), VAV1(3), WAS(1) 13466036 164 22 163 87 110 9 5 24 15 1 0.355 1.000 1.000 353 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(2), ADCY2(1), ADCY5(3), ADCY7(3), ADCY8(1), ADCY9(2), ADRA1A(1), ADRA1D(1), ANXA6(1), ARRB2(1), ATP1A4(2), ATP2A2(1), ATP2A3(3), ATP2B1(1), ATP2B2(3), ATP2B3(1), CACNA1A(3), CACNA1B(4), CACNA1C(5), CACNA1D(2), CACNA1E(9), CACNA1S(3), CAMK2A(1), CAMK4(1), CASQ1(3), CHRM1(1), CHRM2(1), CHRM3(2), CHRM4(1), CHRM5(1), GJA1(1), GJA5(1), GNA11(3), GNAO1(1), GNAQ(1), GNB5(1), GRK4(1), GRK6(1), ITPR1(1), ITPR2(1), ITPR3(1), KCNB1(5), KCNJ5(1), PLCB3(1), PRKAR1B(1), PRKCA(2), PRKCG(1), PRKCH(3), PRKCQ(2), PRKCZ(1), RGS20(2), RGS3(1), RGS6(2), RGS7(3), RGS9(1), RYR1(11), RYR2(8), RYR3(7), SLC8A1(2), SLC8A3(5) 9097284 136 20 135 99 91 10 9 19 6 1 0.766 1.000 1.000 354 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(2), ACTN2(5), ACTN3(2), ARHGAP5(1), BCAR1(1), CD99(1), CDH5(2), CLDN14(2), CLDN2(3), CLDN22(1), CLDN4(1), CTNNA2(4), CTNNA3(4), CTNNB1(1), CTNND1(1), CXCR4(1), F11R(1), GRLF1(1), ITGA4(1), ITGAL(2), ITGAM(3), ITK(3), JAM2(2), MAPK13(1), MLLT4(4), NCF2(1), NOX1(1), NOX3(2), OCLN(1), PIK3CB(2), PIK3CD(1), PIK3R2(1), PLCG2(2), PRKCA(2), PRKCG(1), PTK2(2), PTK2B(2), PTPN11(1), PXN(1), ROCK2(1), SIPA1(2), VAV1(3), VCAM1(2) 6028920 78 20 77 40 51 5 1 9 12 0 0.355 1.000 1.000 355 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(2), ADCY2(1), ADCY5(3), ADCY7(3), ADCY8(1), ADCY9(2), ARRB2(1), ATF4(1), ATP2A2(1), ATP2A3(3), CAMK2A(1), CORIN(2), CRHR1(1), DGKZ(2), ETS2(1), GABPB2(1), GJA1(1), GNAQ(1), GNB5(1), GRK4(1), GRK6(1), GSTO1(1), GUCY1A3(4), IGFBP1(1), IL6(1), ITPR1(1), ITPR2(1), ITPR3(1), MYLK2(3), NFKB1(1), NOS1(3), NOS3(3), PDE4D(1), PLCB3(1), PLCD1(1), PLCG2(2), PRKAR1B(1), PRKCA(2), PRKCH(3), PRKCQ(2), PRKCZ(1), RGS20(2), RGS3(1), RGS6(2), RGS7(3), RGS9(1), RYR1(11), RYR2(8), RYR3(7), SLC8A1(2), SP1(2), TNXB(17) 8496195 121 20 121 78 81 10 9 14 6 1 0.562 1.000 1.000 356 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTG1(1), COL11A1(6), COL11A2(6), COL17A1(1), COL1A1(6), COL1A2(4), COL2A1(6), COL3A1(6), COL4A2(2), COL4A4(10), COL4A6(2), COL5A1(6), COL5A3(8), COL6A1(2), COL6A2(1), COL6A3(7), COL6A6(5), DES(1), DSC1(5), DSC2(1), DSC3(4), DSG1(5), DSG3(4), DSG4(1), FN1(2), GJA1(1), GJA5(1), GJA8(1), GJA9(1), GJC1(2), ITGA6(1), ITGB4(4), KRT1(3), KRT10(3), KRT12(2), KRT13(2), KRT15(1), KRT16(2), KRT17(1), KRT2(1), KRT23(1), KRT24(2), KRT25(2), KRT28(1), KRT31(1), KRT32(1), KRT33A(1), KRT34(1), KRT35(1), KRT36(4), KRT37(1), KRT39(1), KRT4(1), KRT5(2), KRT6B(2), KRT6C(3), KRT7(1), KRT71(3), KRT72(2), KRT74(3), KRT75(1), KRT77(2), KRT78(1), KRT79(2), KRT8(2), KRT85(2), KRT86(1), KRT9(1), LAMA1(3), LAMA2(4), LAMA3(1), LAMA4(1), LAMA5(4), LAMB2(2), LAMB3(2), LAMB4(1), LAMC2(1), LMNA(3), LMNB2(1), RELN(11), THBS1(1), THBS3(1), THBS4(2), TNC(5), TNN(4), TNR(8), TNXB(17), VIM(1), VWF(6) 12283104 253 19 253 118 196 16 4 19 17 1 0.108 1.000 1.000 357 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 126 ABLIM2(1), CXCR4(1), DCC(4), DPYSL2(2), DPYSL5(1), EFNA5(1), EPHA1(3), EPHA2(1), EPHA3(4), EPHA4(3), EPHA6(3), EPHA7(2), EPHB1(6), EPHB3(1), EPHB4(1), EPHB6(2), FYN(1), KRAS(3), L1CAM(2), LIMK2(2), LRRC4C(4), NFATC1(1), NFATC2(3), NFATC4(1), NGEF(1), NRP1(1), NTN4(2), NTNG1(2), PAK2(1), PAK3(1), PAK7(1), PLXNA2(1), PLXNA3(4), PLXNB2(4), PLXNC1(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PTK2(2), RGS3(1), RND1(1), ROBO1(2), ROBO2(1), ROCK2(1), SEMA3A(1), SEMA3C(1), SEMA3F(3), SEMA3G(4), SEMA4A(2), SEMA4D(1), SEMA4F(1), SEMA4G(2), SEMA5A(4), SEMA6B(1), SLIT1(3), SLIT2(6), SLIT3(4), SRGAP2(1), SRGAP3(2), UNC5C(1), UNC5D(4) 9512509 127 19 126 72 87 10 8 14 8 0 0.537 1.000 1.000 358 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(1), CD36(1), CD44(2), COL11A1(6), COL11A2(6), COL1A1(6), COL1A2(4), COL2A1(6), COL3A1(6), COL4A2(2), COL4A4(10), COL4A6(2), COL5A1(6), COL5A3(8), COL6A1(2), COL6A2(1), COL6A3(7), COL6A6(5), FN1(2), FNDC1(3), FNDC4(1), GP9(1), HSPG2(2), ITGA10(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA6(1), ITGA7(3), ITGA8(4), ITGAV(2), ITGB4(4), ITGB5(2), ITGB6(3), ITGB8(1), LAMA1(3), LAMA2(4), LAMA3(1), LAMA4(1), LAMA5(4), LAMB2(2), LAMB3(2), LAMB4(1), LAMC2(1), RELN(11), SDC4(1), SV2A(1), SV2B(5), SV2C(2), THBS1(1), THBS3(1), THBS4(2), TNC(5), TNN(4), TNR(8), TNXB(17), VWF(6) 10986913 197 19 197 92 151 9 4 15 17 1 0.390 1.000 1.000 359 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTG1(1), ACTN1(2), ACTN2(5), ACTN3(2), AKT2(2), AMOTL1(1), ASH1L(3), CASK(3), CLDN14(2), CLDN2(3), CLDN22(1), CLDN4(1), CSDA(2), CTNNA2(4), CTNNA3(4), CTNNB1(1), EPB41L2(5), EPB41L3(2), EXOC3(1), F11R(1), HCLS1(1), INADL(4), JAM2(2), KRAS(3), MAGI1(1), MAGI2(5), MLLT4(4), MYH1(6), MYH10(2), MYH11(3), MYH13(4), MYH14(2), MYH15(7), MYH2(9), MYH3(1), MYH4(5), MYH6(4), MYH7(4), MYH7B(3), MYH8(4), OCLN(1), PARD3(2), PPM1J(1), PPP2R3A(1), PPP2R3B(1), PPP2R4(1), PRKCA(2), PRKCG(1), PRKCH(3), PRKCI(1), PRKCQ(2), PRKCZ(1), PTEN(1), SPTAN1(2), TJAP1(2), TJP3(3), YES1(1) 9509911 146 19 145 83 103 17 8 12 6 0 0.226 1.000 1.000 360 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT2(2), CBL(1), CBLB(1), CBLC(5), CCND3(1), CREBBP(3), CSF2RA(1), CSF2RB(1), EP300(2), GH2(1), GHR(1), IFNA14(1), IFNA16(1), IFNA6(1), IFNA7(1), IFNAR2(1), IL10RA(1), IL12A(1), IL12RB1(2), IL12RB2(1), IL20(1), IL20RA(1), IL21(1), IL21R(3), IL23R(1), IL26(1), IL28RA(1), IL2RA(1), IL2RB(2), IL2RG(1), IL5RA(1), IL6(1), IL6R(1), IL6ST(1), IL7R(3), IL9R(1), IRF9(1), JAK1(1), JAK2(1), JAK3(1), LEPR(3), LIFR(4), OSMR(7), PIAS2(1), PIK3CB(2), PIK3CD(1), PIK3R2(1), PRLR(1), PTPN11(1), SOCS2(1), SOCS4(1), SOCS5(1), SOCS7(1), SOS1(1), SOS2(2), SPRED1(1), SPRY1(2), SPRY3(1), STAM(2), STAT3(3), STAT4(2), STAT5B(1), STAT6(1), TPO(3) 7164086 98 19 98 48 65 7 5 10 11 0 0.421 1.000 1.000 361 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 CACNA1A(3), CRHR1(1), GNA11(3), GNA13(1), GNAO1(1), GNAQ(1), GNAS(3), GRIA1(5), GRIA2(1), GRID2(2), GRM1(2), GRM5(1), GUCY1A3(4), GUCY1B3(2), GUCY2C(3), GUCY2D(1), GUCY2F(1), IGF1(1), IGF1R(4), ITPR1(1), ITPR2(1), ITPR3(1), KRAS(3), MAP2K1(1), NOS1(3), NOS3(3), NPR1(1), NPR2(1), PLA2G2A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCB1(3), PLCB3(1), PLCB4(9), PRKCA(2), PRKCG(1), PRKG1(1), PRKG2(3), RAF1(1), RYR1(11) 5337575 94 19 91 60 59 7 5 15 8 0 0.713 1.000 1.000 362 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTN2(5), ACTN3(2), DES(1), DMD(6), MYBPC1(4), MYBPC2(1), MYBPC3(2), MYH3(1), MYH6(4), MYH7(4), MYH8(4), MYL1(1), MYOM1(1), NEB(11), TNNT2(1), TPM1(1), TTN(82), VIM(1) 6348265 132 19 131 62 96 14 3 11 6 2 0.202 1.000 1.000 363 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(3), CTCFL(3), EHMT1(2), EHMT2(1), EZH1(2), EZH2(1), FBXO11(2), MLL(4), MLL2(5), MLL3(7), MLL4(6), MLL5(2), NSD1(1), PRDM2(2), PRDM7(2), PRDM9(2), PRMT5(1), PRMT8(2), SATB1(1), SETD1A(2), SETD2(2), SMYD3(1), STK38(1), WHSC1(1) 5836156 56 18 56 26 35 6 3 8 4 0 0.573 1.000 1.000 364 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(1), ADORA3(2), ADRA1A(1), ADRA1D(1), AGTR1(2), AGTR2(1), BDKRB2(3), BRS3(2), CCBP2(2), CCR1(2), CCR5(2), CCR8(1), CCR9(1), CHRM1(1), CHRM2(1), CHRM3(2), CHRM4(1), CHRM5(1), CMKLR1(1), CX3CR1(1), CXCR4(1), DRD2(2), DRD5(3), F2R(1), F2RL1(2), FPR1(4), FSHR(2), GPR174(2), GPR37L1(1), GPR50(1), GPR6(1), GPR63(1), GPR85(1), HCRTR2(1), HRH1(1), HTR1A(1), HTR1E(1), HTR2A(1), HTR5A(1), LHCGR(2), MC3R(1), MC5R(1), MTNR1B(1), NMUR1(1), NMUR2(2), NPY1R(4), NPY2R(3), NPY5R(4), NTSR1(1), NTSR2(1), OPRK1(3), OPRM1(2), OR11A1(1), OR1C1(2), P2RY1(2), P2RY10(1), PPYR1(1), PTGDR(3), PTGER2(1), PTGFR(4), PTGIR(1), RGR(1), RHO(1), SSTR3(1), TBXA2R(1), TRHR(1) 5952599 104 18 104 82 67 13 2 16 6 0 0.367 1.000 1.000 365 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(2), ADCY2(1), ADCY5(3), ADCY7(3), ADCY8(1), ADCY9(2), ADSL(2), ADSSL1(1), AK7(3), ALLC(1), AMPD1(3), AMPD2(2), AMPD3(3), APRT(1), CANT1(1), ENPP1(1), ENPP3(1), ENTPD1(2), ENTPD2(1), ENTPD3(1), ENTPD5(1), ENTPD6(1), GUCY1A3(4), GUCY1B3(2), GUCY2C(3), GUCY2D(1), GUCY2F(1), IMPDH1(1), NPR1(1), NPR2(1), NT5C1B(4), NT5E(1), PAPSS1(1), PAPSS2(3), PDE10A(1), PDE11A(2), PDE1A(3), PDE1C(4), PDE2A(4), PDE4C(2), PDE4D(1), PDE7B(3), PDE8B(2), PFAS(1), PKLR(3), PKM2(1), POLA2(2), POLE(2), POLR1A(2), POLR1B(1), POLR2A(2), POLR3A(2), POLR3K(1), PRIM1(1), PRIM2(3), PRPS1L1(2), PRPS2(1), XDH(9) 8020413 115 18 115 50 82 9 4 11 9 0 0.0349 1.000 1.000 366 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 CCNB3(3), CCND3(1), CCNE1(1), CCNE2(3), CDAN1(1), CDH1(1), CDKN2A(2), CHEK2(1), DTX4(1), E2F1(1), EP300(2), ESPL1(3), HDAC3(1), HDAC4(2), HDAC5(1), MAD1L1(1), MCM2(1), MCM4(2), MCM5(1), MPEG1(3), ORC6L(1), RB1(1), SKP2(1), TBC1D8(2), TP53(2) 5398494 39 17 38 19 22 4 1 7 5 0 0.495 1.000 1.000 367 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 INPP5A(1), INPP5B(1), INPPL1(1), ITPK1(1), PI4KA(6), PIK3CB(2), PIK3CD(1), PIP4K2A(1), PIP5K1A(2), PIP5K1B(1), PIP5K1C(1), PLCB1(3), PLCB3(1), PLCB4(9), PLCD1(1), PLCE1(3), PLCG2(2), PLCZ1(2), PTEN(1), SYNJ1(2), SYNJ2(3) 3613237 45 17 44 22 23 2 3 12 5 0 0.608 1.000 1.000 368 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CDS1(1), DGKA(1), DGKB(3), DGKD(2), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), INPP5A(1), INPP5B(1), INPPL1(1), ITPK1(1), ITPR1(1), ITPR2(1), ITPR3(1), PI4KA(6), PIK3C2B(1), PIK3C2G(4), PIK3CB(2), PIK3CD(1), PIK3R2(1), PIP4K2A(1), PIP5K1A(2), PIP5K1B(1), PIP5K1C(1), PLCB1(3), PLCB3(1), PLCB4(9), PLCD1(1), PLCE1(3), PLCG2(2), PLCZ1(2), PRKCA(2), PRKCG(1), PTEN(1), SYNJ1(2), SYNJ2(3) 6057252 71 17 70 39 44 2 4 14 7 0 0.677 1.000 1.000 369 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 110 ANAPC1(2), ANAPC5(2), ANAPC7(1), CCNB3(3), CCND3(1), CCNE1(1), CCNE2(3), CDC27(1), CDKN2A(2), CHEK2(1), CREBBP(3), E2F1(1), EP300(2), ESPL1(3), FZR1(1), MAD1L1(1), MCM2(1), MCM4(2), MCM5(1), ORC6L(1), RB1(1), SKP2(1), SMC1B(2), TP53(2) 6725765 39 17 38 21 21 3 3 7 5 0 0.690 1.000 1.000 370 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 143 APC(2), APC2(1), AXIN1(2), BTRC(1), CAMK2A(1), CCND3(1), CHD8(5), CREBBP(3), CSNK1A1L(2), CTNNB1(1), DAAM1(1), DAAM2(1), DKK1(1), DKK2(2), DVL3(1), EP300(2), FBXW11(1), FZD1(1), FZD5(1), LRP5(5), LRP6(3), MAPK8(1), MAPK9(3), MMP7(2), NFATC1(1), NFATC2(3), NFATC4(1), PLCB1(3), PLCB3(1), PLCB4(9), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRICKLE1(1), PRICKLE2(1), PRKACG(2), PRKCA(2), PRKCG(1), PRKX(1), ROCK2(1), SENP2(1), SFRP2(1), SFRP4(1), TCF7(1), TCF7L1(1), TCF7L2(2), TP53(2), WIF1(1), WNT10A(1), WNT10B(1), WNT16(1), WNT2(2), WNT3(1), WNT3A(1), WNT5A(1), WNT5B(1), WNT7A(3), WNT7B(2), WNT8A(1) 7860081 100 17 99 56 58 6 6 15 15 0 0.726 1.000 1.000 371 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(2), ADCY2(1), ADCY5(3), ADCY7(3), ADCY8(1), ADCY9(2), ATF4(1), CACNA1C(5), CACNA1D(2), CACNA1F(1), CACNA1S(3), CAMK2A(1), EGFR(3), GNA11(3), GNAQ(1), GNAS(3), ITPR1(1), ITPR2(1), ITPR3(1), KRAS(3), MAP2K1(1), MAP2K6(1), MAP2K7(1), MAP3K2(2), MAP3K4(3), MAPK13(1), MAPK8(1), MAPK9(3), PLA2G2A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCB1(3), PLCB3(1), PLCB4(9), PLD2(1), PRKACG(2), PRKCA(2), PRKX(1), PTK2B(2), RAF1(1), SOS1(1), SOS2(2) 6166827 86 17 84 57 55 4 5 15 7 0 0.797 1.000 1.000 372 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 65 CCND3(1), CCNE1(1), CCNE2(3), CDKN2A(2), E2F1(1), MCM2(1), MCM4(2), MCM5(1), MYT1(2), ORC6L(1), POLA2(2), POLE(2), PRIM1(1), RB1(1), RPA2(1), TNXB(17), TP53(2) 3908664 41 16 40 24 27 1 2 4 7 0 0.712 1.000 1.000 373 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(2), ADCY2(1), ADCY5(3), ADCY7(3), ADCY8(1), ADCY9(2), AKAP1(1), AKAP11(2), AKAP3(2), AKAP4(1), AKAP6(2), AKAP8(1), AKAP9(2), GNA11(3), GNA13(1), GNAO1(1), GNAQ(1), GNB5(1), ITPR1(1), KRAS(3), PDE1A(3), PDE1B(2), PDE1C(4), PDE4C(2), PDE4D(1), PDE7B(3), PDE8B(2), PLCB3(1), PPP3CA(1), PPP3CC(1), PRKACG(2), PRKAR1B(1), PRKCA(2), PRKCG(1), PRKCH(3), PRKCI(1), PRKCQ(2), PRKCZ(1) 5716816 67 16 66 54 43 5 3 14 2 0 0.976 1.000 1.000 374 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(2), CD14(1), CD1A(1), CD1B(1), CD1C(3), CD1D(2), CD2(1), CD22(2), CD33(1), CD34(1), CD36(1), CD38(2), CD3D(1), CD44(2), CD5(1), CD55(1), CD8B(1), CR1(4), CR2(3), CSF1R(3), CSF2RA(1), DNTT(1), FLT3(2), GP9(1), HLA-DRA(2), IL1R1(2), IL1R2(1), IL2RA(1), IL5RA(1), IL6(1), IL6R(1), IL7R(3), IL9R(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA6(1), ITGAM(3), KIT(4), MME(1), THPO(1), TPO(3) 3978287 68 16 67 42 44 6 4 8 6 0 0.777 1.000 1.000 375 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 125 CD247(1), FAS(1), FASLG(3), FCGR3A(1), FYN(1), HLA-B(1), IFNA14(1), IFNA16(1), IFNA6(1), IFNA7(1), IFNAR2(1), ITGAL(2), KIR2DL1(4), KIR2DL3(2), KIR2DL4(1), KIR3DL1(4), KLRC2(1), KLRD1(1), KLRK1(2), KRAS(3), LCK(1), MAP2K1(1), NCR1(1), NCR2(3), NFATC1(1), NFATC2(3), NFATC4(1), PIK3CB(2), PIK3CD(1), PIK3R2(1), PLCG2(2), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRF1(3), PRKCA(2), PRKCG(1), PTK2B(2), PTPN11(1), RAF1(1), SH2D1A(1), SHC3(1), SOS1(1), SOS2(2), SYK(1), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(1), TYROBP(1), ULBP3(1), VAV1(3) 5537346 79 16 79 48 48 6 4 12 9 0 0.802 1.000 1.000 376 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 73 AKT2(2), BTK(3), FCER1A(1), FYN(1), KRAS(3), MAP2K1(1), MAP2K6(1), MAP2K7(1), MAPK13(1), MAPK8(1), MAPK9(3), MS4A2(1), PIK3CB(2), PIK3CD(1), PIK3R2(1), PLA2G2A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCG2(2), PRKCA(2), RAF1(1), SOS1(1), SOS2(2), SYK(1), VAV1(3) 3528424 42 16 42 22 23 2 2 8 7 0 0.735 1.000 1.000 377 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(2), AGTR2(1), ATP8A1(3), BDKRB2(3), BRS3(2), CCR1(2), CCR5(2), CCR8(1), CX3CR1(1), CXCR4(1), CXCR6(1), FPR1(4), FSHR(2), LHCGR(2), MC3R(1), MC5R(1), NPY1R(4), NPY2R(3), NPY5R(4), NTSR1(1), NTSR2(1), OPRK1(3), OPRM1(2), PPYR1(1), SSTR3(1), TACR1(1), TACR2(2), TACR3(1), TRHR(1) 2578626 54 16 54 36 38 6 0 8 2 0 0.167 1.000 1.000 378 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVRL1(1), BMPR2(1), CDS1(1), CLK2(1), DGKA(1), DGKB(3), DGKD(2), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), INPP5A(1), INPPL1(1), MOS(2), NEK1(1), PIK3C2B(1), PIK3C2G(4), PIK3CB(2), PLCB1(3), PLCB3(1), PLCB4(9), PLCD1(1), PLCG2(2), PLK3(1), PRKACG(2), PRKAR1B(1), PRKCA(2), PRKCG(1), PRKCH(3), PRKCQ(2), PRKCZ(1), PRKG1(1), RAF1(1), RPS6KA2(1), RPS6KA4(2), RPS6KB1(1) 5497042 64 16 63 42 44 0 6 7 7 0 0.925 1.000 1.000 379 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT2(2), CDKN2A(2), CREB5(2), ERBB4(6), GAB1(1), IGF1(1), IGFBP1(1), INPPL1(1), IRS1(1), IRS4(2), NOLC1(1), PAK2(1), PAK3(1), PAK7(1), PARD3(2), PIK3CD(1), PREX1(1), PTEN(1), PTK2(2), PTPN1(1), RPS6KA2(1), RPS6KB1(1), SLC2A4(1), SOS1(1), SOS2(2), TSC1(1), TSC2(1) 3803599 39 16 39 22 17 6 2 6 8 0 0.849 1.000 1.000 380 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ACTN1(2), AKT2(2), ARHGEF6(3), ARHGEF7(1), BCAR1(1), CDKN2A(2), CRK(1), FYN(1), GRB7(1), GRLF1(1), ITGA10(1), ITGA4(1), ITGA5(1), ITGA6(1), ITGA7(3), ITGA8(4), MAP2K7(1), MAPK8(1), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(2), MAPK9(3), MYLK(2), MYLK2(3), P4HB(1), PAK2(1), PAK3(1), PAK7(1), PIK3CB(2), PKLR(3), PLCG2(2), PTEN(1), PTK2(2), RAF1(1), RHO(1), ROCK2(1), SOS1(1), SOS2(2), TLN1(1), WAS(1), ZYX(1) 5977061 66 16 66 34 35 2 1 16 12 0 0.661 1.000 1.000 381 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 BCL2(1), CAMK4(1), CREBBP(3), EP300(2), FCER1A(1), FCGR3A(1), GATA3(2), GRLF1(1), ICOS(1), IL2RA(1), IL6(1), ITK(3), MAP2K7(1), MAPK8(1), MAPK9(3), MEF2B(1), MYF5(2), NFATC1(1), NFATC2(3), NFATC4(1), NPPB(1), NUP214(2), P2RX7(1), PPP3CB(1), PPP3CC(1), PTPRC(2), SLA(1), SP1(2), TRAF2(1), TRPV6(5), VAV1(3), XPO5(1) 4477976 52 15 52 24 36 2 4 5 5 0 0.289 1.000 1.000 382 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(4), ADH1C(3), ADH6(2), ADH7(1), AGPAT1(2), AGPAT4(1), AKR1A1(1), AKR1B1(1), ALDH9A1(1), CEL(1), DGKA(1), DGKB(3), DGKD(2), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), GK(1), GLA(1), GLB1(2), LCT(3), LIPF(4), LIPG(1), PNLIPRP1(2), PNLIPRP2(1), PPAP2C(1) 2374123 48 15 46 24 35 4 2 5 2 0 0.287 1.000 1.000 383 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AKT2(2), APAF1(1), BAX(1), BCL2(1), BIRC3(1), CAPN2(2), CASP8(1), CFLAR(1), CSF2RB(1), DFFA(1), DFFB(1), FAS(1), FASLG(3), IL1R1(2), IL1RAP(1), IRAK2(2), NFKB1(1), NTRK1(4), PIK3CB(2), PIK3CD(1), PIK3R2(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRKACG(2), PRKAR1B(1), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(1), TP53(2), TRAF2(1) 4091469 45 15 45 30 24 0 5 5 11 0 0.934 1.000 1.000 384 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 CADM1(1), CADM3(2), CD2(1), CD22(2), CD276(1), CD34(1), CD6(2), CD86(1), CD8B(1), CD99(1), CDH1(1), CDH15(1), CDH2(1), CDH4(4), CDH5(2), CLDN14(2), CLDN2(3), CLDN22(1), CLDN4(1), CNTN1(2), CNTN2(1), CNTNAP1(1), CNTNAP2(4), F11R(1), HLA-B(1), HLA-DPB1(1), HLA-DQA1(2), HLA-DQB1(1), HLA-DRA(2), ICOS(1), ITGA4(1), ITGA6(1), ITGA8(4), ITGAL(2), ITGAM(3), ITGAV(2), ITGB8(1), JAM2(2), L1CAM(2), MAG(1), NEGR1(2), NEO1(4), NFASC(2), NRCAM(1), NRXN1(3), NRXN2(2), NRXN3(2), OCLN(1), PDCD1(1), PDCD1LG2(2), PTPRC(2), PTPRF(2), SDC4(1), SELE(9), SELP(1), SELPLG(1), SIGLEC1(2), VCAM1(2), VCAN(1) 7130436 106 15 106 44 81 7 1 7 10 0 0.0245 1.000 1.000 385 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(2), ADCY2(1), ADCY5(3), ADCY7(3), ADCY8(1), ADCY9(2), CAMK2A(1), CREB3L2(1), CREBBP(3), CTNNB1(1), DVL3(1), EDN1(2), EP300(2), FZD1(1), FZD5(1), GNAO1(1), GNAQ(1), GNAS(3), KIT(4), KRAS(3), MAP2K1(1), PLCB1(3), PLCB3(1), PLCB4(9), PRKACG(2), PRKCA(2), PRKCG(1), PRKX(1), RAF1(1), TCF7(1), TCF7L1(1), TCF7L2(2), WNT10A(1), WNT10B(1), WNT16(1), WNT2(2), WNT3(1), WNT3A(1), WNT5A(1), WNT5B(1), WNT7A(3), WNT7B(2), WNT8A(1) 5281570 77 15 76 49 47 6 7 13 4 0 0.723 1.000 1.000 386 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ACTG1(1), ARHGEF2(2), CD14(1), CDH1(1), CTNNB1(1), FYN(1), HCLS1(1), NCL(1), OCLN(1), PRKCA(2), ROCK2(1), TLR4(1), TLR5(4), TUBA1A(1), TUBA1B(4), TUBA3C(1), TUBA3E(1), TUBA4A(1), TUBB3(2), TUBB4Q(2), TUBB6(2), TUBB8(2), WAS(1) 2588153 35 15 34 22 20 2 4 7 2 0 0.758 1.000 1.000 387 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ACTG1(1), ARHGEF2(2), CD14(1), CDH1(1), CTNNB1(1), FYN(1), HCLS1(1), NCL(1), OCLN(1), PRKCA(2), ROCK2(1), TLR4(1), TLR5(4), TUBA1A(1), TUBA1B(4), TUBA3C(1), TUBA3E(1), TUBA4A(1), TUBB3(2), TUBB4Q(2), TUBB6(2), TUBB8(2), WAS(1) 2588153 35 15 34 22 20 2 4 7 2 0 0.758 1.000 1.000 388 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CLK2(1), COL2A1(6), DHX16(1), DHX38(1), DHX8(1), DICER1(3), GIPC1(1), LOC440563(1), LSM7(1), NONO(1), POLR2A(2), PRPF8(2), PTBP2(1), SF3A1(1), SF3A2(1), SF3A3(1), SF3B1(2), SF3B2(2), SF4(1), SFRS16(2), SFRS7(1), SNRPB(1), SRPK1(3), SRPK2(1), SRRM1(1) 5255801 39 15 38 16 23 8 2 1 5 0 0.420 1.000 1.000 389 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(2), ADH1B(4), ADH1C(3), ADH5(1), ADH6(2), ADH7(1), AKR1C2(1), AKR1C4(1), ALDH3B2(1), CYP1A1(3), CYP1A2(1), CYP2B6(3), CYP2C18(2), CYP2C19(2), CYP2C8(2), CYP2C9(3), CYP2E1(2), CYP2F1(1), CYP2S1(1), CYP3A4(3), CYP3A5(1), GSTA1(1), GSTA5(1), UGT1A10(3), UGT1A3(1), UGT1A4(3), UGT1A5(1), UGT2B10(1), UGT2B11(1), UGT2B15(4), UGT2B28(2), UGT2B4(2), UGT2B7(1) 2789578 61 14 59 32 44 1 7 4 5 0 0.265 1.000 1.000 390 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(3), DLL1(1), DTX2(2), DTX3L(1), DTX4(1), DVL3(1), EP300(2), JAG1(1), MAML3(1), NCSTN(1), NOTCH1(1), NOTCH2(11), NOTCH3(4), NOTCH4(8), SNW1(1) 3391505 39 14 39 22 20 2 2 12 3 0 0.818 1.000 1.000 391 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 97 AKT2(2), CASP8(1), CD14(1), CD86(1), IFNA14(1), IFNA16(1), IFNA6(1), IFNA7(1), IFNAR2(1), IL12A(1), IL6(1), IRF5(1), LBP(1), MAP2K1(1), MAP2K6(1), MAP2K7(1), MAPK13(1), MAPK8(1), MAPK9(3), NFKB1(1), PIK3CB(2), PIK3CD(1), PIK3R2(1), TLR1(2), TLR2(1), TLR4(1), TLR5(4), TLR7(1), TLR8(1), TLR9(1), TRAF6(1) 4396100 39 14 39 29 23 2 2 6 6 0 0.949 1.000 1.000 392 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT2(2), CARD11(8), CBL(1), CBLB(1), CBLC(5), CD247(1), CD3D(1), CD8B(1), FYN(1), GRAP2(1), ICOS(1), ITK(3), KRAS(3), LCK(1), MALT1(1), NFATC1(1), NFATC2(3), NFATC4(1), NFKB1(1), PAK2(1), PAK3(1), PAK7(1), PDCD1(1), PIK3CB(2), PIK3CD(1), PIK3R2(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRKCQ(2), PTPRC(2), RASGRP1(1), SOS1(1), SOS2(2), VAV1(3) 4978877 60 14 60 36 35 4 5 7 9 0 0.852 1.000 1.000 393 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(2), ADCY8(1), ATF4(1), CACNA1C(5), CAMK2A(1), CAMK4(1), CREBBP(3), EP300(2), GNAQ(1), GRIA1(5), GRIA2(1), GRIN1(1), GRIN2A(7), GRIN2B(3), GRM1(2), GRM5(1), ITPR1(1), ITPR2(1), ITPR3(1), KRAS(3), MAP2K1(1), PLCB1(3), PLCB3(1), PLCB4(9), PPP1R1A(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRKACG(2), PRKCA(2), PRKCG(1), PRKX(1), RAF1(1), RPS6KA2(1), RPS6KA6(2) 4803490 72 14 71 48 46 3 8 10 5 0 0.798 1.000 1.000 394 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 130 ACACB(2), AKT2(2), CBL(1), CBLB(1), CBLC(5), CRK(1), CRKL(1), EIF4EBP1(1), EXOC7(2), FASN(2), FOXO1(1), G6PC2(1), GCK(5), GYS1(1), GYS2(2), INSR(7), IRS1(1), IRS4(2), KRAS(3), LIPE(2), MAP2K1(1), MAPK8(1), MAPK9(3), MKNK2(1), PCK1(3), PDE3A(1), PHKA1(3), PHKB(1), PIK3CB(2), PIK3CD(1), PIK3R2(1), PKLR(3), PKM2(1), PPARGC1A(2), PPP1R3A(1), PRKAA2(1), PRKACG(2), PRKAG3(1), PRKAR1B(1), PRKCI(1), PRKCZ(1), PRKX(1), PTPN1(1), PTPRF(2), PYGB(1), PYGM(1), RAF1(1), RHEB(1), RPS6KB1(1), SH2B2(1), SHC3(1), SLC2A4(1), SOCS2(1), SOCS4(1), SORBS1(1), SOS1(1), SOS2(2), TSC1(1), TSC2(1) 7863193 95 14 95 46 57 10 4 15 9 0 0.381 1.000 1.000 395 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 89 BCAR1(1), CAPN11(2), CAPN2(2), CAPN3(1), CAPN6(2), CAPN9(2), CAPNS1(1), CRK(1), FYN(1), GIT2(3), ITGA10(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA6(1), ITGA7(3), ITGA8(4), ITGAD(1), ITGAE(1), ITGAL(2), ITGAM(3), ITGAV(2), ITGAX(1), ITGB4(4), ITGB5(2), ITGB6(3), ITGB8(1), MAP2K1(1), MAP2K6(1), MYLK2(3), PAK2(1), PAK3(1), PIK3R2(1), PTK2(2), PXN(1), RHO(1), ROCK2(1), SDCCAG8(1), SHC3(1), SORBS1(1), SOS1(1), TLN1(1), ZYX(1) 6494704 67 14 67 38 43 2 1 12 8 1 0.605 1.000 1.000 396 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(2), ADCY2(1), ADCY5(3), ADCY7(3), ADCY8(1), ADSL(2), ALLC(1), AMPD1(3), AMPD2(2), AMPD3(3), APRT(1), ATP5F1(1), ATP5J(1), CANT1(1), ENPP1(1), ENPP3(1), ENTPD1(2), ENTPD2(1), GUCY1A3(4), GUCY1B3(2), GUCY2C(3), GUCY2D(1), GUCY2F(1), IMPDH1(1), NPR1(1), NPR2(1), NT5E(1), PAPSS1(1), PAPSS2(3), PDE1A(3), PDE4C(2), PDE4D(1), PDE6B(3), PDE6C(1), PDE7B(3), PFAS(1), PKLR(3), PKM2(1), POLE(2), POLG(1), POLL(1), POLQ(2), POLR1B(1), POLR2A(2), PRPS1L1(2), PRPS2(1) 6273582 79 14 79 37 58 8 2 5 6 0 0.0801 1.000 1.000 397 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(2), CCR5(2), CELSR1(4), CELSR2(8), CELSR3(1), CHRM2(1), CHRM3(2), EMR3(4), F2R(1), FSHR(2), GHRHR(1), GPR116(2), GPR133(1), GPR55(1), GPR56(1), GPR61(2), GRM1(2), LGR6(5), LPHN2(3), LPHN3(1), NTSR1(1), OR2M4(1), OR8G2(2), PTGFR(4), SMO(3) 3258165 57 13 57 35 38 5 3 4 7 0 0.284 1.000 1.000 398 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS2(2), ADH1A(2), ADH1B(4), ADH1C(3), ADH5(1), ADH6(2), ADH7(1), AKR1A1(1), ALDH3B2(1), ALDH7A1(2), ALDH9A1(1), ALDOB(1), ALDOC(1), ENO2(1), G6PC2(1), GCK(5), GPI(2), HK2(1), HK3(3), LDHA(1), LDHAL6B(3), PGK2(3), PKLR(3), PKM2(1) 2876834 46 13 44 29 34 2 2 6 2 0 0.532 1.000 1.000 399 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ACAD8(1), ADH1A(2), ADH1B(4), ADH1C(3), ADH5(1), ADH6(2), ADH7(1), AKR1C4(1), ALDH7A1(2), ALDH9A1(1), CEL(1), CYP7A1(1), LIPA(3) 1564926 24 13 22 19 15 4 1 4 0 0 0.856 1.000 1.000 400 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), ARSD(1), ARSE(1), CYP11B1(1), CYP11B2(2), CYP19A1(3), HEMK1(1), HSD11B1(1), HSD3B1(1), HSD3B2(1), METTL2B(2), METTL6(1), PRMT5(1), PRMT8(2), STS(1), SULT2A1(1), SULT2B1(1), UGT1A10(3), UGT1A3(1), UGT1A4(3), UGT1A5(1), UGT2B10(1), UGT2B11(1), UGT2B15(4), UGT2B28(2), UGT2B4(2), UGT2B7(1) 2433551 41 13 41 20 28 3 6 1 3 0 0.243 1.000 1.000 401 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(1), AGPAT1(2), AGPAT4(1), CDS1(1), CHAT(1), DGKA(1), DGKB(3), DGKD(2), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), GNPAT(1), GPD1(1), MYST3(4), MYST4(5), PLA2G2A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLD2(1), PNPLA3(1), PPAP2C(1) 3211612 40 13 40 21 26 2 2 4 6 0 0.591 1.000 1.000 402 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 FARSA(1), GARS(1), HARS(1), HARS2(1), IARS(2), IARS2(2), KARS(1), LARS(2), MARS(3), MTFMT(1), NARS(1), NARS2(2), QARS(2), RARS(2), RARS2(2), SARS(2), SARS2(1), TARS2(1), VARS(4), VARS2(1) 2712456 33 13 33 15 20 5 0 4 4 0 0.338 1.000 1.000 403 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL2(1), AKT2(2), BTC(1), CAMK2A(1), CBL(1), CBLB(1), CBLC(5), CRK(1), CRKL(1), EGF(3), EGFR(3), EIF4EBP1(1), ERBB4(6), GAB1(1), KRAS(3), MAP2K1(1), MAP2K7(1), MAPK8(1), MAPK9(3), NRG1(3), PAK2(1), PAK3(1), PAK7(1), PIK3CB(2), PIK3CD(1), PIK3R2(1), PLCG2(2), PRKCA(2), PRKCG(1), PTK2(2), RAF1(1), RPS6KB1(1), SHC3(1), SOS1(1), SOS2(2), STAT5B(1) 5045304 61 13 61 34 35 3 4 13 6 0 0.849 1.000 1.000 404 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(2), BDKRB2(3), C1QA(1), C1QB(1), C1QC(1), C1R(1), C1S(3), C2(3), C3(4), C5AR1(2), C6(1), C7(5), C8A(3), C8B(1), CD55(1), CFB(3), CFH(4), CR1(4), CR2(3), F11(1), F12(1), F13A1(2), F13B(1), F2(1), F2R(1), F7(1), F8(2), F9(1), FGA(3), FGB(1), KLKB1(1), KNG1(1), MASP2(2), MBL2(1), PLG(1), PROC(1), PROS1(1), SERPINA1(1), SERPINA5(2), SERPINC1(1), SERPIND1(1), SERPINE1(1), SERPINF2(2), SERPING1(4), THBD(2), VWF(6) 4420459 89 13 88 44 58 7 4 13 7 0 0.496 1.000 1.000 405 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 61 AKT2(2), BLNK(1), BTK(3), CARD11(8), CD22(2), CR2(3), KRAS(3), LILRB3(1), MALT1(1), NFATC1(1), NFATC2(3), NFATC4(1), NFKB1(1), PIK3CB(2), PIK3CD(1), PIK3R2(1), PLCG2(2), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), RASGRP3(2), SYK(1), VAV1(3) 3646829 46 13 46 23 29 3 4 4 6 0 0.443 1.000 1.000 406 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(1), ADCY8(1), CACNA1A(3), CACNA1B(4), GNAS(3), GRM4(1), ITPR3(1), KCNB1(5), PDE1A(3), PRKACG(2), PRKX(1), SCNN1B(2), SCNN1G(2), TAS1R1(2), TAS1R2(1), TAS1R3(1), TAS2R1(1), TAS2R10(2), TAS2R13(2), TAS2R16(1), TAS2R38(2), TAS2R39(2), TAS2R41(1), TAS2R60(2), TAS2R7(1), TAS2R9(1), TRPM5(2) 2768149 50 13 50 35 36 2 5 5 2 0 0.461 1.000 1.000 407 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BAX(1), BTK(3), CAD(2), CASP8(1), DAXX(2), DEDD2(2), DFFA(1), EGFR(3), FAF1(1), FAIM2(1), MAP2K7(1), MAP3K5(1), MAPK8(1), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(2), MAPK9(3), NFKB1(1), NFKBIL1(1), PTPN13(1), TP53(2), TRAF2(1) 3551653 36 13 36 17 21 1 1 8 5 0 0.666 1.000 1.000 408 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT2(2), DRD2(2), EGFR(3), ITPR1(1), ITPR2(1), ITPR3(1), KCNJ5(1), PI3(2), PIK3CB(2), PLCB1(3), PLCB3(1), PLCB4(9), RAF1(1), RGS20(2), SOS1(1), SOS2(2), STAT3(3) 2868884 37 13 36 19 19 2 3 8 5 0 0.639 1.000 1.000 409 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(3), AGTR1(2), AGTR2(1), CMA1(2), COL4A2(2), COL4A3(4), COL4A4(10), COL4A5(3), COL4A6(2), REN(2) 1234589 31 12 31 13 26 0 1 3 1 0 0.880 1.000 1.000 410 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(2), AMY2A(1), AMY2B(1), ASCC3(2), ATP13A2(1), DDX23(1), DDX4(2), DDX47(1), DDX56(2), ENPP1(1), ENPP3(1), EP400(1), ERCC2(1), G6PC2(1), GAA(1), GBA(2), GBA3(1), GBE1(1), GCK(5), GPI(2), GYS1(1), GYS2(2), HK2(1), HK3(3), IFIH1(1), MGAM(12), MOV10L1(8), NUDT8(1), PYGB(1), PYGM(1), RAD54B(2), SETX(2), SI(8), SMARCA2(2), UGT1A10(3), UGT1A3(1), UGT1A4(3), UGT1A5(1), UGT2B10(1), UGT2B11(1), UGT2B15(4), UGT2B28(2), UGT2B4(2), UGT2B7(1) 5985893 94 12 93 36 67 6 6 5 10 0 0.0365 1.000 1.000 411 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1C(2), ACVRL1(1), AMHR2(4), BMP5(1), BMP6(1), BMPR2(1), CREBBP(3), EP300(2), GDF5(2), GDF7(2), ID2(2), INHBA(1), INHBC(2), LEFTY1(1), LEFTY2(1), LTBP1(5), ROCK2(1), RPS6KB1(1), SMAD5(1), SMAD6(1), SMAD9(2), SP1(2), THBS1(1), THBS3(1), THBS4(2), ZFYVE16(1), ZFYVE9(1) 4886845 45 12 45 32 24 2 5 8 6 0 0.952 1.000 1.000 412 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT2(2), BCL2(1), BCR(2), BLNK(1), BTK(3), CD22(2), CR2(3), ITPR1(1), ITPR2(1), ITPR3(1), NFATC1(1), NFATC2(3), PIK3CD(1), PLCG2(2), PPP3CA(1), PPP3CB(1), PPP3CC(1), PTPRC(2), RAF1(1), SOS1(1), SOS2(2), SYK(1), VAV1(3) 3621391 37 12 37 19 23 3 1 6 4 0 0.465 1.000 1.000 413 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT2(2), BCR(2), BTK(3), CDKN2A(2), GAB1(1), ITPR1(1), ITPR2(1), ITPR3(1), PLCG2(2), PREX1(1), PTEN(1), PTPRC(2), RPS6KA2(1), RPS6KB1(1), SAG(2), SYK(1), VAV1(3) 2695854 27 12 27 19 16 2 2 3 4 0 0.818 1.000 1.000 414 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 AKT2(2), BTK(3), CDKN2A(2), IARS(2), IGFBP1(1), PTEN(1), RPS6KA2(1), RPS6KB1(1), SOS1(1), SOS2(2) 1770974 16 12 16 10 8 1 1 3 3 0 0.842 1.000 1.000 415 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(2), AXIN1(2), CCND3(1), CTNNB1(1), DVL3(1), FZD1(1), FZD5(1), LDLR(3), MAPK9(3), PPP2R5C(1), PPP2R5E(2), PRKCA(2), PRKCG(1), PRKCH(3), PRKCI(1), PRKCQ(2), PRKCZ(1), SFRP4(1), TCF7(1), WNT10A(1), WNT10B(1), WNT16(1), WNT2(2), WNT3(1), WNT5A(1), WNT5B(1), WNT7A(3), WNT7B(2) 2904608 43 12 43 28 29 3 2 4 5 0 0.764 1.000 1.000 416 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BLNK(1), BTK(3), MAP2K1(1), MAPK8(1), NFATC1(1), NFATC2(3), NFATC4(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(2), RAF1(1), SOS1(1), SYK(1), SYT1(2), VAV1(3) 1858396 24 11 24 13 17 0 1 4 2 0 0.629 1.000 1.000 417 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ADH1A(2), ADH1B(4), ADH1C(3), ADH6(2), ADH7(1), AKR1C4(1), ALDH9A1(1), CEL(1), CYP7A1(1) 1146253 17 11 15 17 11 3 1 2 0 0 0.942 1.000 1.000 418 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(3), FCER1A(1), MAP2K1(1), MAP2K7(1), MAPK8(1), NFATC1(1), NFATC2(3), NFATC4(1), PAK2(1), PLA2G4A(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), RAF1(1), SOS1(1), SYK(1), SYT1(2), VAV1(3) 2105155 27 11 27 12 18 1 1 4 3 0 0.469 1.000 1.000 419 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(1), AGPAT1(2), AGPAT4(1), CDS1(1), CHAT(1), DGKA(1), DGKB(3), DGKD(2), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), GNPAT(1), GPD1(1), PAFAH2(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(2), PLCG2(2), PPAP2C(1) 2452149 31 11 31 18 23 1 1 3 3 0 0.574 1.000 1.000 420 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(1), ALDOC(1), ENO2(1), GCK(5), GPI(2), HK2(1), HK3(3), LDHA(1), LDHAL6B(3), MDH1(1), PC(2), PCK1(3), PDHX(1), PGK2(3), PKLR(3), PKM2(1) 2105874 32 11 32 18 24 2 1 3 2 0 0.351 1.000 1.000 421 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACOX1(1), ACOX3(4), ACSL3(1), ACSL5(1), ACSL6(2), ADH1A(2), ADH1B(4), ADH1C(3), ADH5(1), ADH6(2), ADH7(1), ALDH7A1(2), ALDH9A1(1), CPT1A(3), CPT1C(1), CYP4A11(1), CYP4A22(3), EHHADH(2), HADHA(2), HSD17B4(1) 2430228 39 11 37 19 29 2 1 3 4 0 0.269 1.000 1.000 422 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP4A(1), ATP5F1(1), ATP5J(1), ATP5O(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1G3(1), COX15(1), COX8A(1), NDUFA4(1), NDUFB2(1), NDUFB6(1), NDUFS7(2) 2775521 20 11 20 10 12 1 2 4 1 0 0.517 1.000 1.000 423 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 A4GNT(2), ALG14(1), ALG3(1), C1GALT1(1), CHST1(1), CHST4(1), EXT2(1), EXTL3(1), FUT8(1), GALNT13(2), GALNT14(5), GALNT6(5), GALNTL2(1), GALNTL5(1), GCNT3(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(1), HS3ST3B1(1), HS6ST2(1), HS6ST3(2), MAN1A1(1), MAN1B1(1), MAN2A1(1), MGAT4A(2), MGAT5(1), MGAT5B(1), NDST1(2), NDST3(3), NDST4(4), RPN2(1), ST3GAL1(1), ST6GAL1(1), WBSCR17(1) 5370952 52 11 52 32 40 1 1 7 3 0 0.600 1.000 1.000 424 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(1), ACOX1(1), ACOX2(1), ACOX3(4), ACSL3(1), ACSL5(1), ACSL6(2), CD36(1), CPT1A(3), CPT1C(1), CYP4A11(1), CYP4A22(3), CYP7A1(1), CYP8B1(1), EHHADH(2), FABP1(2), GK(1), GK2(2), HMGCS2(2), ME1(1), PCK1(3), PPARG(2), RXRA(1), SLC27A1(1), SLC27A2(2), SLC27A6(1), SORBS1(1), UBC(1) 3242806 44 11 43 29 34 4 1 0 5 0 0.610 1.000 1.000 425 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP5A(1), INPPL1(1), PIK3C2B(1), PIK3C2G(4), PIK3CB(2), PLCB1(3), PLCB3(1), PLCB4(9), PLCD1(1), PLCG2(2) 2182894 25 11 24 15 13 0 2 5 5 0 0.823 1.000 1.000 426 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(1), DAXX(2), EGF(3), EGFR(3), ETS2(1), HOXA7(1), MAP2K1(1), MAP2K6(1), MAP2K7(1), MAP3K5(1), MAPK13(1), MAPK8(1), NFKB1(1), PRKCA(2), PRKCG(1), PRKCH(3), PRKCQ(2), RAF1(1), SP1(2), TRAF2(1) 2407035 30 11 30 18 20 0 3 6 1 0 0.724 1.000 1.000 427 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 AKT2(2), ARHGEF11(2), BTK(3), INPPL1(1), ITPR1(1), ITPR2(1), ITPR3(1), MYLK(2), MYLK2(3), PAK2(1), PAK3(1), PAK7(1), PIK3CD(1), PTEN(1), RHO(1), ROCK2(1), SAG(2) 3436763 25 11 25 13 18 0 0 4 3 0 0.607 1.000 1.000 428 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT2(2), BCR(2), BLNK(1), BTK(3), MAP2K1(1), NFKB1(1), NFKBIL1(1), PI3(2), PIK3CD(1), PLCG2(2), RAF1(1), SERPINA4(1), SOS1(1), SOS2(2), SYK(1), VAV1(3) 2601578 25 11 25 14 13 3 1 6 2 0 0.721 1.000 1.000 429 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(3), F2(1), F2RL1(2), MAP2K5(1), MAPK8(1), PLD2(1), PLD3(1), PTK2(2), RAF1(1), RASAL1(1), VAV1(3) 1350932 17 11 17 13 11 1 0 4 1 0 0.831 1.000 1.000 430 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 41 CD3D(1), FYN(1), LCK(1), MAP2K1(1), MAPK8(1), NFATC1(1), NFATC2(3), NFATC4(1), NFKB1(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(2), RAF1(1), SOS1(1), SYT1(2), VAV1(3) 2315180 23 11 23 11 15 0 0 4 4 0 0.564 1.000 1.000 431 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), ARSD(1), ARSE(1), CYP11B1(1), CYP11B2(2), HSD11B1(1), HSD3B1(1), HSD3B2(1), STS(1), SULT2A1(1), UGT1A10(3), UGT1A3(1), UGT1A4(3), UGT1A5(1), UGT2B15(4), UGT2B4(2) 1337175 25 10 25 14 15 2 6 1 1 0 0.478 1.000 1.000 432 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(1), BAX(1), BCL2(1), BIRC3(1), BNIP3L(1), CASP8(1), DFFA(1), DFFB(1), FAS(1), FASLG(3), HELLS(2), IRF5(1), IRF6(3), NFKB1(1), PLEKHG5(2), PRF1(3), TNFRSF10B(1), TNFRSF21(1), TNFRSF25(1), TNFSF10(1), TP53(2), TRAF1(1), TRAF2(1) 2811663 32 10 32 22 18 3 3 2 6 0 0.877 1.000 1.000 433 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BAX(1), BCL2(1), CASP8(1), DAXX(2), DFFA(1), DFFB(1), FAS(1), FASLG(3), NFKB1(1), NTRK1(4), PTPN13(1), TRAF1(1), TRAF2(1), TRAF6(1) 2120905 21 10 21 18 9 0 3 3 6 0 0.982 1.000 1.000 434 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGTR2(1), CAMK2A(1), F2(1), FYN(1), GNA11(3), JAK2(1), MAP2K1(1), MAPK8(1), MAPT(1), MYLK(2), PRKCA(2), PTK2B(2), RAF1(1), SOS1(1), STAT3(3), SYT1(2) 2039643 24 10 23 15 12 0 2 8 2 0 0.806 1.000 1.000 435 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(2), ADH1B(4), ADH1C(3), ADH6(2), ADH7(1), AKR1A1(1), ALDH3B2(1), ALDH9A1(1), ALDOB(1), ALDOC(1), ENO2(1), GCK(5), GPI(2), HK2(1), HK3(3), LDHA(1), PKLR(3), PKM2(1) 2414380 34 10 32 25 27 2 2 2 1 0 0.704 1.000 1.000 436 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(2), ADH1B(4), ADH1C(3), ADH6(2), ADH7(1), AKR1A1(1), ALDH3B2(1), ALDH9A1(1), ALDOB(1), ALDOC(1), ENO2(1), GCK(5), GPI(2), HK2(1), HK3(3), LDHA(1), PKLR(3), PKM2(1) 2414380 34 10 32 25 27 2 2 2 1 0 0.704 1.000 1.000 437 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX12B(1), ALOX15(2), ALOX15B(2), ALOX5(2), CBR3(1), CYP2B6(3), CYP2C18(2), CYP2C19(2), CYP2C8(2), CYP2C9(3), CYP2E1(2), CYP4A11(1), CYP4A22(3), CYP4F2(1), EPHX2(1), GPX1(1), GPX5(2), GPX6(1), PLA2G2A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PTGES2(1), PTGS2(2) 1904026 42 10 42 23 32 3 1 1 5 0 0.272 1.000 1.000 438 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ARRB2(1), CAMK2A(1), CLCA2(2), CLCA4(1), CNGA3(4), CNGB1(2), GUCA1A(1), PDC(1), PDE1C(4), PRKACG(2), PRKG1(1), PRKG2(3), PRKX(1) 1469565 24 10 23 17 19 1 1 3 0 0 0.702 1.000 1.000 439 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(2), ACSL3(1), ACSL5(1), ACSL6(2), AKT2(2), CAMKK1(1), CD36(1), CPT1A(3), CPT1C(1), G6PC2(1), IRS1(1), IRS4(2), JAK1(1), JAK2(1), JAK3(1), LEPR(3), MAPK8(1), MAPK9(3), NFKB1(1), PCK1(3), PPARGC1A(2), PRKAA2(1), PRKAG3(1), PRKCQ(2), PTPN11(1), RXRA(1), SLC2A4(1), STAT3(3), TRAF2(1) 4096127 45 10 45 34 25 5 3 6 6 0 0.949 1.000 1.000 440 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1G3(1), EGFR(3), F11R(1), JAM2(2), MAPK13(1), MAPK8(1), MAPK9(3), NFKB1(1), PLCG2(2), PTPN11(1), PTPRZ1(2) 3450921 25 10 25 20 18 1 1 4 1 0 0.940 1.000 1.000 441 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 CRK(1), CRKL(1), GAB1(1), HGF(3), MAP2K1(1), MAPK8(1), PTEN(1), PTK2(2), PTK2B(2), PTPN11(1), PXN(1), RAF1(1), SOS1(1), STAT3(3) 2133656 20 10 20 12 9 0 1 8 2 0 0.908 1.000 1.000 442 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(2), CREB5(2), GNAQ(1), MAP2K7(1), MAPK8(1), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(2), MAPK9(3) 1391970 17 10 17 13 7 1 0 6 3 0 0.954 1.000 1.000 443 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 22 APC(2), GNAQ(1), ITPR1(1), ITPR2(1), ITPR3(1), KCNJ5(1), RHO(1), RYR1(11) 2209761 19 10 19 14 12 0 1 3 3 0 0.758 1.000 1.000 444 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(1), BAX(1), BCL2(1), BIRC3(1), CASP8(1), FAS(1), FASLG(3), NFKB1(1), PARP1(2), PRF1(3), TNFSF10(1), TP53(2), TRAF1(1), TRAF2(1) 1831340 20 9 20 14 10 1 2 0 7 0 0.906 1.000 1.000 445 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1QB(1), C1R(1), C1S(3), C2(3), C3(4), C6(1), C7(5), C8A(3), MASP2(2), MBL2(1) 1031562 25 9 25 14 18 1 2 3 1 0 0.609 1.000 1.000 446 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(4), AGXT2(2), AOC2(1), BHMT(2), CHDH(1), DAO(1), GARS(1), PLCG2(2), SARDH(2), SARS(2), SHMT2(1) 2075387 19 9 19 14 14 1 1 3 0 0 0.745 1.000 1.000 447 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(2), GNAQ(1), GNAS(3), MAP2K1(1), NFATC1(1), NFATC2(3), NFATC4(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(2), PRKAR1B(1), PRKCA(2), RAF1(1), SYT1(2) 1709861 23 9 23 18 18 0 0 3 2 0 0.889 1.000 1.000 448 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(1), UGT1A10(3), UGT1A3(1), UGT1A4(3), UGT1A5(1), UGT2B10(1), UGT2B11(1), UGT2B15(4), UGT2B28(2), UGT2B4(2), UGT2B7(1) 1322481 20 9 20 10 12 0 5 1 2 0 0.477 1.000 1.000 449 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(4), AGXT2(2), AOC2(1), BHMT(2), CHDH(1), DAO(1), GARS(1), GNMT(1), PHGDH(2), PIPOX(1), SARDH(2), SARS(2), SARS2(1), SDS(1), SHMT2(1), TARS2(1) 2113845 24 9 24 13 16 1 1 3 3 0 0.449 1.000 1.000 450 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA1(1), ALDH7A1(2), ALDH9A1(1), AOX1(3), AUH(1), BCAT1(1), BCAT2(1), BCKDHB(1), EHHADH(2), HADHA(2), HIBADH(1), HMGCS2(2), HSD17B4(1), IVD(1), OXCT1(1), OXCT2(1), PCCB(1) 2128434 23 9 23 12 17 1 1 3 1 0 0.573 1.000 1.000 451 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ASS1(1), DAO(1), NOS1(3), NOS3(3), P4HA3(1), RARS(2), RARS2(2) 1760860 14 9 14 13 10 2 0 0 2 0 0.868 1.000 1.000 452 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX15(2), ALOX5(2), CYP1A2(1), CYP2C18(2), CYP2C19(2), CYP2C8(2), CYP2C9(3), CYP2E1(2), CYP3A4(3), CYP3A5(1), PLA2G2A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2) 1170131 27 9 27 16 22 1 0 0 4 0 0.428 1.000 1.000 453 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(4), ADH1C(3), ADH5(1), ADH6(2), ADH7(1), ALDH7A1(2), ALDH9A1(1) 652357 16 9 14 11 11 1 1 3 0 0 0.719 1.000 1.000 454 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT2(2), EIF4EBP1(1), IGF1(1), PIK3CB(2), PIK3CD(1), PIK3R2(1), PRKAA2(1), RHEB(1), RICTOR(2), RPS6KA2(1), RPS6KA6(2), RPS6KB1(1), TSC1(1), TSC2(1), ULK1(1) 2591895 19 9 19 13 9 4 2 1 3 0 0.884 1.000 1.000 455 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IL1R1(2), IL1RAP(1), IL1RN(1), IL6(1), IRAK2(2), MAP2K6(1), MAPK8(1), NFKB1(1), TRAF6(1) 1446521 11 9 11 10 6 0 1 2 2 0 0.914 1.000 1.000 456 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A2(2), COL4A3(4), COL4A4(10), COL4A5(3), COL4A6(2), F11(1), F12(1), F2(1), F2R(1), F8(2), F9(1), FGA(3), FGB(1), KLKB1(1), PROC(1), PROS1(1), SERPINC1(1), SERPING1(4) 2181265 40 9 40 22 33 1 1 4 1 0 0.969 1.000 1.000 457 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(4), C6(1), C7(5), IL6(1), ITGA4(1), ITGAL(2), SELP(1), SELPLG(1), VCAM1(2) 1197579 18 9 18 12 10 1 2 2 3 0 0.820 1.000 1.000 458 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 CAMK4(1), CREBBP(3), EDN1(2), F2(1), FKBP1A(1), HAND2(1), IGF1(1), MAP2K1(1), MAPK8(1), MYH2(9), NFATC1(1), NFATC2(3), NFATC4(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(2), PRKAR1B(1), RAF1(1), RPS6KB1(1), SYT1(2) 2506510 36 9 36 19 27 2 2 3 2 0 0.437 1.000 1.000 459 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 GRIN1(1), GRIN2A(7), GRIN2B(3), NOS1(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(2), PRKAR1B(1), PRKCA(2), SYT1(2) 1251222 24 9 24 17 17 3 1 1 2 0 0.606 1.000 1.000 460 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(3), AR(1), ESR1(1), HNF4A(1), NR1D2(1), NR1I2(1), NR1I3(1), NR2E1(1), NR5A2(3), PGR(1), PPARG(2), ROR1(2), RORC(2), RXRA(1) 2054776 21 9 21 12 15 1 1 4 0 0 0.559 1.000 1.000 461 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(1), CD36(1), CREBBP(3), EHHADH(2), EP300(2), FABP1(2), HSD17B4(1), ME1(1), NCOA1(1), NCOR1(4), NRIP1(1), PRKACG(2), PRKAR1B(1), PRKCA(2), PTGS2(2), RB1(1), RXRA(1), SP1(2), STAT5B(1) 3127326 31 9 30 18 20 3 3 2 3 0 0.630 1.000 1.000 462 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX15(2), ALOX5(2), CBR3(1), CYP4F2(1), LPO(3), MPO(3), PLA2G2A(1), PLA2G4A(3), PLA2G6(2), PRDX1(2), PTGES2(1), PTGS2(2), TPO(3) 1378369 26 9 26 17 19 1 0 2 4 0 0.573 1.000 1.000 463 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(5), CDR1(1), IL6ST(1), RPL14(1), RPL22(1), RPL27A(1), RPL5(1), RPL7(1), RPLP0(1), RPS2(1), RPS29(1), RPS3A(1), RPS6KA2(1), RPS6KA6(2), RPS6KB1(1), RPSA(1), UBC(1) 2551012 22 9 22 17 13 2 2 2 3 0 0.917 1.000 1.000 464 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT2(2), ARHGEF11(2), BCL2(1), GNA13(1), LPA(3), MAP3K5(1), MAPK8(1), NFKB1(1), NFKBIL1(1), PI3(2), PIK3CB(2), PLD2(1), PLD3(1), PTK2(2), ROCK2(1), SERPINA4(1), TBXA2R(1) 2405202 24 9 24 14 14 1 0 5 4 0 0.776 1.000 1.000 465 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(1), CD3D(1), FBXW7(1), GRAP2(1), ITK(3), LCK(1), NFKB1(1), NFKBIL1(1), PAK2(1), PAK3(1), PAK7(1), PTPRC(2), RAF1(1), RASGRP1(1), RASGRP3(2), SOS1(1), SOS2(2), VAV1(3) 2709118 25 9 25 16 15 0 1 5 4 0 0.805 1.000 1.000 466 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT2(2), APC(2), AXIN1(2), CTNNB1(1), DKK1(1), DKK2(2), DKK3(2), LRP1(1), SENP2(1), WIF1(1) 1958785 15 9 14 16 8 2 1 2 2 0 0.986 1.000 1.000 467 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(4), ADH1C(3), ADH6(2), ADH7(1) 277259 12 8 10 7 9 0 1 2 0 0 0.641 1.000 1.000 468 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(2), AXIN1(2), BMP10(2), BMP5(1), BMPR2(1), CTNNB1(1), FZD1(1), NPPB(1), RFC1(1), TGFBR3(1) 1765543 13 8 13 12 8 1 0 1 3 0 0.974 1.000 1.000 469 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(4), ALDH4A1(1), ALDH9A1(1), AOC2(1), DAO(1), NOS1(3), NOS3(3), P4HA3(1), P4HB(1), RARS(2) 2163015 18 8 18 19 12 4 0 0 2 0 0.940 1.000 1.000 470 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABP1(4), ALDH9A1(1), AOC2(1), CNDP1(2), DPYD(4), EHHADH(2), GAD2(1), HADHA(2), MLYCD(1), SDS(1) 1432616 19 8 19 12 15 1 1 1 1 0 0.633 1.000 1.000 471 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), MAP2K1(1), NFKB1(1), PLCB1(3), PRKCA(2), RAF1(1) 768727 10 8 10 7 7 0 0 3 0 0 0.804 1.000 1.000 472 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1QB(1), C1R(1), C1S(3), C2(3), C3(4), C6(1), C7(5), C8A(3) 843061 22 8 22 10 16 1 2 3 0 0 0.401 1.000 1.000 473 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1QB(1), C1R(1), C1S(3), C2(3), C3(4), C6(1), C7(5), C8A(3), C8B(1) 1005036 23 8 23 13 17 1 2 3 0 0 0.603 1.000 1.000 474 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGF(3), EGFR(3), JAK1(1), MAP2K1(1), MAPK8(1), PRKCA(2), RAF1(1), SOS1(1), STAT3(3) 1833275 16 8 16 10 9 0 1 4 2 0 0.828 1.000 1.000 475 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 APC(2), AXIN1(2), CD14(1), CTNNB1(1), FZD1(1), GJA1(1), LBP(1), NFKB1(1), TLR4(1) 1480563 11 8 11 11 5 2 1 1 2 0 0.975 1.000 1.000 476 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(1), ALDOB(1), ALDOC(1), GMDS(2), GMPPB(1), HK2(1), HK3(3), PFKFB2(1), PFKFB3(1), PFKFB4(2) 1816766 14 8 14 12 12 1 0 1 0 0 0.766 1.000 1.000 477 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ADC(1), ALDH4A1(1), ALDH5A1(2), CAD(2), GAD2(1), GFPT1(1), GFPT2(1), GLS2(2), GPT(1), GSS(1), NADSYN1(2), QARS(2) 1951314 17 8 17 10 11 1 2 3 0 0 0.619 1.000 1.000 478 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABP1(4), ALDH7A1(2), ALDH9A1(1), AOC2(1), CNDP1(2), DPYD(4), EHHADH(2), GAD2(1), HADHA(2), MLYCD(1) 1333507 20 8 20 12 17 1 1 1 0 0 0.565 1.000 1.000 479 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(1), ARSE(1), DEGS1(1), ENPP7(4), GAL3ST1(3), GBA(2), GLA(1), GLB1(2), LCT(3), NEU1(1), NEU2(3), NEU3(1), PPAP2C(1), SGMS1(2), SGMS2(1), SGPP2(2), UGT8(1) 1741556 30 8 30 15 20 3 1 4 2 0 0.338 1.000 1.000 480 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(1), ALDOC(1), GPT(1), MDH1(1), ME1(1), PGK2(3), PKLR(3), PKM2(1), TKTL2(3) 1001691 15 8 15 11 11 1 0 2 1 0 0.684 1.000 1.000 481 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPP(1), ALPPL2(2), ASCC3(2), ATP13A2(1), DDX23(1), DDX4(2), DDX47(1), DDX56(2), EP400(1), ERCC2(1), IFIH1(1), MOV10L1(8), NUDT8(1), QDPR(1), RAD54B(2), SETX(2), SMARCA2(2), SPR(1) 3067308 33 8 33 16 24 3 0 1 5 0 0.358 1.000 1.000 482 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ADCY9(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1C2(1), ATP6V1G3(1), ERO1L(1), GNAS(3), PLCG2(2), PRKCA(2), SEC61A2(1), TRIM23(1) 1835870 20 8 20 16 14 1 2 2 1 0 0.808 1.000 1.000 483 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(1), ADRA1D(1), CHRM1(1), CHRM2(1), CHRM3(2), CHRM4(1), CHRM5(1), DRD2(2), DRD5(3), HRH1(1), HTR1A(1), HTR1E(1), HTR2A(1), HTR5A(1) 1234306 18 8 18 16 11 3 1 1 2 0 0.551 1.000 1.000 484 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP5O(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1G3(1), ATP7A(3), ATP7B(2), COX8A(1), NDUFA4(1), NDUFB2(1), NDUFB6(1) 1903848 16 8 16 11 9 0 4 3 0 0 0.770 1.000 1.000 485 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(2), AXIN1(2), CREBBP(3), CTNNB1(1), EP300(2), FZD1(1), TRRAP(5) 1638061 16 8 16 14 7 2 1 3 3 0 0.971 1.000 1.000 486 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(2), CANT1(1), CTPS2(2), DPYD(4), ENTPD1(2), NT5E(1), POLE(2), POLG(1), POLL(1), POLQ(2), POLR1B(1), POLR2A(2), UNG(1) 2834517 22 8 22 13 17 1 0 2 2 0 0.638 1.000 1.000 487 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 23 BCR(2), BLNK(1), MAP2K1(1), MAPK8IP3(2), PAPPA(4), SOS1(1), SYK(1), VAV1(3) 1531516 15 8 15 12 8 2 1 4 0 0 0.905 1.000 1.000 488 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), ITPR1(1), ITPR2(1), ITPR3(1), PDE6A(1), PDE6B(3), PDE6C(1), SLC6A13(2), TF(1) 1748580 12 8 12 9 9 1 1 1 0 0 0.685 1.000 1.000 489 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CCR5(2), CXCR4(1), GNAQ(1), MAPK8(1), PRKCA(2), PTK2B(2), SYT1(2) 685715 11 7 11 9 8 1 0 2 0 0 0.812 1.000 1.000 490 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CSNK1D(1), DRD2(2), GRM1(2), PLCB1(3), PPP3CA(1), PRKACG(2), PRKAR1B(1) 780850 12 7 12 15 9 0 1 1 1 0 0.989 1.000 1.000 491 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOB(1), ALDOC(1), GCK(5), GMDS(2), GMPPB(1), HK2(1), HK3(3), PFKFB3(1), PFKFB4(2) 1176607 18 7 18 12 16 1 0 1 0 0 0.483 1.000 1.000 492 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(1), GAA(1), GCK(5), GLA(1), GLB1(2), HK2(1), HK3(3), LCT(3), MGAM(12) 1593365 29 7 29 16 24 3 0 2 0 0 0.360 1.000 1.000 493 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSD(1), ARSE(1), GAL3ST1(3), GBA(2), GLA(1), GLB1(2), LCT(3), NEU1(1), NEU2(3), NEU3(1), PPAP2C(1) 1180356 19 7 19 13 13 3 1 2 0 0 0.737 1.000 1.000 494 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 26 ACLY(4), ACO1(1), MDH1(1), OGDH(2), OGDHL(4), PC(2), PCK1(3), SUCLG2(1) 1443605 18 7 18 10 15 1 0 2 0 0 0.464 1.000 1.000 495 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 ADSL(2), ADSSL1(1), AGXT2(2), ASRGL1(1), ASS1(1), CAD(2), CRAT(1), GAD2(1), GPT(1), NARS(1), NARS2(2), PC(2) 1878949 17 7 17 11 13 1 1 2 0 0 0.653 1.000 1.000 496 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 ALDH7A1(2), ALDH9A1(1), EHHADH(2), EHMT1(2), EHMT2(1), HADHA(2), HSD17B4(1), NSD1(1), OGDH(2), OGDHL(4), PIPOX(1), PLOD1(1), SETD1A(2), SHMT2(1) 2856201 23 7 23 12 20 3 0 0 0 0 0.372 1.000 1.000 497 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 C1GALT1(1), GALNT13(2), GALNT14(5), GALNT6(5), GALNTL2(1), GALNTL5(1), GCNT3(1), ST3GAL1(1), WBSCR17(1) 1591479 18 7 18 12 16 0 0 1 1 0 0.741 1.000 1.000 498 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(2), AGPAT4(1), PAFAH2(1), PLA2G2A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLD2(1), PPAP2C(1) 1151540 13 7 13 11 8 1 0 1 3 0 0.910 1.000 1.000 499 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACB(2), ACSS2(2), ALDH7A1(2), ALDH9A1(1), EHHADH(2), HADHA(2), LDHA(1), LDHAL6B(3), MLYCD(1), PCCB(1), SUCLG2(1) 1967120 18 7 18 13 16 1 0 0 1 0 0.724 1.000 1.000 500 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), ACSM1(1), ALDH5A1(2), ALDH7A1(2), ALDH9A1(1), BDH1(1), DDHD1(3), EHHADH(2), GAD2(1), HADHA(2), HMGCS2(2), HSD17B4(1), OXCT1(1), OXCT2(1), PLA1A(2), PPME1(1) 2008946 24 7 24 14 18 2 2 0 2 0 0.513 1.000 1.000 501 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B4GALNT1(1), FUT1(2), FUT2(1), FUT3(1), FUT9(2), PIGB(1), PIGU(2), ST3GAL1(1), ST6GALNAC3(2), ST6GALNAC5(2) 2388175 15 7 15 14 8 2 0 4 1 0 0.949 1.000 1.000 502 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 ALDH9A1(1), EHHADH(2), EHMT1(2), EHMT2(1), HADHA(2), PLOD1(1), SDS(1), SHMT2(1) 1812632 11 7 11 11 7 3 0 0 1 0 0.898 1.000 1.000 503 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(2), CCR5(2), CXCR4(1), IL12A(1), IL12RB1(2), IL12RB2(1), IL18R1(1) 988522 10 7 10 8 7 2 0 1 0 0 0.750 1.000 1.000 504 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 PLCB1(3), PRKCA(2), VAV1(3) 634465 8 7 8 5 7 0 0 1 0 0 0.738 1.000 1.000 505 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP5(1), ARHGAP6(1), ARHGEF11(2), ARHGEF5(3), ARPC1B(3), MYLK(2), PIP5K1A(2), PIP5K1B(1), TLN1(1) 2223287 16 7 16 10 11 0 1 3 1 0 0.692 1.000 1.000 506 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(1), FLNA(1), FLNC(4), FSCN1(1), FSCN3(1), MYH2(9), MYLK(2), MYLK2(3), PAK2(1), PAK3(1), PAK7(1), RHO(1), ROCK2(1) 2351178 27 7 27 17 21 2 2 2 0 0 0.553 1.000 1.000 507 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 CREB5(2), MAP2K1(1), MKNK2(1), MOS(2), NFKB1(1), RPS6KA2(1), SOS1(1), SOS2(2) 1445702 11 7 11 9 7 1 0 3 0 0 0.933 1.000 1.000 508 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), MAP2K6(1), MAPK8(1), NFKB1(1), TLR2(1), TLR4(1), TLR7(1), TLR9(1), TRAF6(1) 1778489 9 7 9 9 6 1 1 1 0 0 0.916 1.000 1.000 509 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 GNAQ(1), NFATC1(1), NFATC2(3), NFKB1(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(2), PRKAR1B(1), SYT1(2), VIPR2(1) 1363818 15 7 15 16 11 0 0 2 2 0 0.972 1.000 1.000 510 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A2(2), COL4A3(4), COL4A4(10), COL4A5(3), COL4A6(2), P4HB(1), SLC23A2(2), SLC2A3(1) 1221688 25 7 25 15 22 1 0 2 0 0 0.985 1.000 1.000 511 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 19 ACO1(1), MDH1(1), PC(2), PCK1(3), SUCLG2(1) 984934 8 6 8 7 7 1 0 0 0 0 0.811 1.000 1.000 512 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(4), GABBR1(1), GRM1(2), GRM3(4), GRM4(1), GRM5(1), GRM7(3), GRM8(7) 1020648 23 6 23 23 16 4 0 1 2 0 0.868 1.000 1.000 513 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(4), ALDH3B2(1), ALDH9A1(1), AOC2(1), CNDP1(2), DDC(2), HARS(1), HDC(2), HNMT(1), PRPS2(1) 1197103 16 6 16 10 11 1 0 2 2 0 0.524 1.000 1.000 514 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(4), ADC(1), ALDH7A1(2), ALDH9A1(1), AOC2(1), ASS1(1) 1431767 10 6 10 9 8 1 0 1 0 0 0.826 1.000 1.000 515 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG14(1), ALG3(1), DOLPP1(1), FUT8(1), MAN1A1(1), MAN1B1(1), MAN2A1(1), MGAT4A(2), MGAT5(1), MGAT5B(1), RPN2(1), ST6GAL1(1) 2080912 13 6 13 14 8 1 0 3 1 0 0.967 1.000 1.000 516 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(2), CD3D(1), ETV5(2), IL12A(1), IL12RB1(2), IL12RB2(1), IL18R1(1), JAK2(1), MAP2K6(1), MAPK8(1), STAT4(2) 917133 15 6 15 10 10 1 0 3 1 0 0.798 1.000 1.000 517 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 MDH1(1), OGDH(2), PC(2), PDHX(1), PDK4(1), PDP2(1), SUCLG2(1) 1407851 9 6 9 8 7 1 0 1 0 0 0.876 1.000 1.000 518 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 CAPN2(2), CAPNS1(1), EGF(3), EGFR(3), MYLK(2), PRKACG(2), PRKAR1B(1), PTK2(2), PXN(1), TLN1(1) 1601185 18 6 18 13 14 0 0 1 3 0 0.740 1.000 1.000 519 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(1), GNA13(1), GNAQ(1), MYLK(2), PLCB1(3), PRKCA(2) 1026313 10 6 10 8 7 0 0 3 0 0 0.930 1.000 1.000 520 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 19 KLRC2(1), KLRD1(1), MAP2K1(1), PTK2B(2), SYK(1), VAV1(3) 891595 9 6 9 5 7 0 1 1 0 0 0.644 1.000 1.000 521 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(2), F2(1), F2R(1), GNA13(1), GNAQ(1), PLCB1(3), PRKCA(2), PTK2B(2) 1268531 13 6 13 11 10 0 0 3 0 0 0.930 1.000 1.000 522 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ADH5(1), AKR1B1(1), ALDH9A1(1), LDHA(1), MDH1(1), ME1(1), PC(2), PCK1(3), PKLR(3), PKM2(1) 1825417 15 6 15 14 10 3 0 1 1 0 0.915 1.000 1.000 523 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), CD44(2), FCGR3A(1), IL6R(1), TNFRSF8(3) 634393 9 6 9 12 3 0 1 2 3 0 0.995 1.000 1.000 524 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT2(2), IARS(2), IL2RG(1), JAK1(1), JAK2(1), JAK3(1), PI3(2), RPS6KB1(1), SERPINA4(1), SOS1(1), SOS2(2), STAT6(1) 1812862 16 6 16 12 8 2 1 4 1 0 0.926 1.000 1.000 525 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(2), CD3D(1), CREBBP(3), GNAS(3), HLA-DRA(2), LCK(1), PRKACG(2), PRKAR1B(1), PTPRC(2) 1110203 17 5 17 12 15 0 1 0 1 0 0.711 1.000 1.000 526 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1G3(1) 747544 7 5 7 6 4 0 1 2 0 0 0.835 1.000 1.000 527 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 25 ADCY1(2), CAMK2A(1), GNAS(3), PRKACG(2), PRKAR1B(1), PRKCA(2), SOS1(1) 1396139 12 5 12 12 10 0 1 1 0 0 0.944 1.000 1.000 528 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(2), CD3D(1), CREBBP(3), GNAS(3), HLA-DRA(2), LCK(1), PRKACG(2), PRKAR1B(1), PTPRC(2) 1110203 17 5 17 12 15 0 1 0 1 0 0.711 1.000 1.000 529 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(2), CD2(1), CD33(1), CD5(1), IL12A(1), ITGAX(1), TLR2(1), TLR4(1), TLR7(1), TLR9(1) 914038 11 5 11 11 8 0 1 1 1 0 0.801 1.000 1.000 530 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15(2), ALOX15B(2), ALOX5(2), PLA2G2A(1), PLA2G6(2), PTGS2(2) 737577 11 5 11 10 10 0 0 0 1 0 0.718 1.000 1.000 531 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1G3(1) 747544 7 5 7 6 4 0 1 2 0 0 0.835 1.000 1.000 532 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(1), CALCR(2), CD97(1), CRHR1(1), ELTD1(3), EMR1(5), GHRHR(1), GLP1R(2), LPHN1(1), LPHN2(3), LPHN3(1), VIPR2(1) 1284588 22 5 22 23 14 1 1 2 4 0 0.953 1.000 1.000 533 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(1), GLB1(2), HEXA(1), LCT(3), ST3GAL1(1), ST6GALNAC3(2), ST6GALNAC5(2) 817413 12 5 12 9 7 2 0 3 0 0 0.820 1.000 1.000 534 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACB(2), ACOT12(1), ACSS2(2), AKR1B1(1), ALDH7A1(2), ALDH9A1(1), LDHA(1), LDHAL6B(3), MDH1(1), ME1(1), PC(2), PCK1(3), PKLR(3), PKM2(1) 2313584 24 5 24 18 19 3 0 0 2 0 0.726 1.000 1.000 535 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(1), CREBBP(3), EP300(2), FYN(1), IL2RG(1), IL7R(3), JAK1(1), JAK3(1), LCK(1), PTK2B(2), STAT5B(1) 1377788 17 5 17 10 14 1 1 0 1 0 0.671 1.000 1.000 536 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 CPT1A(3), LEPR(3), PRKAA2(1) 723462 7 5 7 6 6 0 0 1 0 0 0.889 1.000 1.000 537 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IL1R1(2), NFKB1(1), TLR4(1), TRAF6(1) 1169198 5 5 5 9 3 0 1 1 0 0 0.994 1.000 1.000 538 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(3), EP300(2), MAP2K6(1), NFKB1(1), TLR2(1) 1463337 8 5 8 9 7 0 1 0 0 0 0.955 1.000 1.000 539 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1G3(1), FDXR(1) 794886 8 5 8 7 5 0 1 2 0 0 0.834 1.000 1.000 540 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(2), GNAS(3), PLCE1(3), PRKACG(2), PRKAR1B(1) 714185 11 5 11 9 11 0 0 0 0 0 0.793 1.000 1.000 541 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(3), EP300(2), HDAC3(1), NFKB1(1), TRAF6(1) 1103552 8 5 8 6 7 0 1 0 0 0 0.803 1.000 1.000 542 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 MTNR1B(1), PTGDR(3), PTGER2(1), PTGFR(4), PTGIR(1), TBXA2R(1) 552506 11 5 11 10 9 1 1 0 0 0 0.651 1.000 1.000 543 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1G3(1) 747544 7 5 7 6 4 0 1 2 0 0 0.835 1.000 1.000 544 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNAS(3), PRKACG(2), PRKAR1B(1), PRKCA(2) 465924 8 4 8 7 8 0 0 0 0 0 0.860 1.000 1.000 545 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(3), EP300(2), NCOA3(1), PRKACG(2), PRKAR1B(1), RXRA(1) 1025246 10 4 10 9 7 1 1 1 0 0 0.929 1.000 1.000 546 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(2), CFTR(4), GNAS(3), PRKACG(2), PRKAR1B(1), SLC9A3R1(1) 629254 13 4 13 8 13 0 0 0 0 0 0.558 1.000 1.000 547 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(2), FHL5(1), FSHR(2), GNAS(3) 462309 8 4 8 5 8 0 0 0 0 0 0.657 1.000 1.000 548 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 OPRK1(3), POLR2A(2), PRKACG(2), PRKAR1B(1) 633502 8 4 8 9 7 1 0 0 0 0 0.900 1.000 1.000 549 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2(1), F2R(1), F7(1), FGA(3), FGB(1), PROC(1), PROS1(1), SERPINC1(1) 804594 10 4 10 9 7 2 0 1 0 0 0.937 1.000 1.000 550 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 29 ANPEP(2), G6PD(1), GPX1(1), GPX5(2), GSS(1), GSTA1(1), PGD(1) 852222 9 4 9 11 7 2 0 0 0 0 0.924 1.000 1.000 551 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 BDH1(1), HMGCS2(2), OXCT1(1), OXCT2(1) 352183 5 4 5 4 5 0 0 0 0 0 0.818 1.000 1.000 552 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 ANPEP(2), G6PD(1), GPX1(1), GPX5(2), GPX6(1), GSS(1), GSTA1(1), GSTA5(1) 1036659 10 4 10 14 8 2 0 0 0 0 0.968 1.000 1.000 553 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 PAPSS1(1), PAPSS2(3), SULT2A1(1), SULT2B1(1), SUOX(2) 449011 8 4 8 5 7 1 0 0 0 0 0.568 1.000 1.000 554 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 GALNS(1), GBA(2), GLB1(2), HEXA(1), HPSE(1), HPSE2(1), IDUA(1), LCT(3), NAGLU(1), NEU1(1), NEU2(3), NEU3(1), SPAM1(2) 1677810 20 4 20 10 13 2 1 1 3 0 0.402 1.000 1.000 555 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), FUT8(1), MAN1A1(1), MAN1B1(1), MGAT4A(2), MGAT5(1), RPN2(1), ST6GAL1(1) 988463 9 4 9 8 7 1 0 1 0 0 0.816 1.000 1.000 556 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 IFNAR2(1), MAPK8(1), NFKB1(1), TRAF6(1) 545346 4 4 4 6 3 0 0 1 0 0 0.986 1.000 1.000 557 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 HDAC3(1), NCOA1(1), NCOA3(1), POLR2A(2), RXRA(1) 1225923 6 4 6 5 4 1 0 1 0 0 0.851 1.000 1.000 558 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(2), GPT(1), LDHA(1), NCL(1) 447440 5 4 5 4 5 0 0 0 0 0 0.734 1.000 1.000 559 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(2), PRKACG(2) 878604 4 3 4 7 4 0 0 0 0 0 0.990 1.000 1.000 560 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK2A(1), CAMK4(1), CAMKK1(1), SYT1(2) 572460 5 3 5 8 3 0 1 1 0 0 0.976 1.000 1.000 561 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(1), HS3ST2(1), HS3ST3A1(1), HS3ST3B1(1) 315333 4 3 4 5 3 0 0 1 0 0 0.917 1.000 1.000 562 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(2), GNAS(3), PRKAA2(1), PRKACG(2), PRKAR1B(1) 751530 9 3 9 9 9 0 0 0 0 0 0.913 1.000 1.000 563 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 LCT(3), PYGM(1) 653136 4 3 4 4 3 1 0 0 0 0 0.781 1.000 1.000 564 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1), GRIA2(1), JUND(1) 177103 3 3 3 6 2 0 1 0 0 0 0.982 1.000 1.000 565 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(1), HS3ST2(1), HS3ST3A1(1), HS3ST3B1(1) 315333 4 3 4 5 3 0 0 1 0 0 0.917 1.000 1.000 566 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACB(2), FASN(2), OLAH(1) 782087 5 3 5 7 4 0 0 1 0 0 0.945 1.000 1.000 567 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 GLB1(2), HEXA(1), LCT(3), NEU1(1), NEU2(3), NEU3(1) 1000692 11 3 11 8 7 2 1 1 0 0 0.757 1.000 1.000 568 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 10 ACLY(4), ACO1(1), ACSS2(2), MDH1(1) 620291 8 3 8 5 6 0 0 2 0 0 0.655 1.000 1.000 569 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 HLA-DRA(2), IL5RA(1), IL6(1) 263806 4 3 4 4 3 0 1 0 0 0 0.799 1.000 1.000 570 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 HLA-DRA(2), IL12A(1), IL6(1) 648302 4 3 4 5 2 0 1 1 0 0 0.910 1.000 1.000 571 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 PRKCA(2), PTK2B(2) 337462 4 3 4 5 4 0 0 0 0 0 0.856 1.000 1.000 572 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(2), GNAS(3), MYT1(2), PRKACG(2), PRKAR1B(1) 1007281 10 3 10 13 10 0 0 0 0 0 0.959 1.000 1.000 573 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 GLB1(2), HEXA(1), LCT(3), NEU1(1), NEU2(3), NEU3(1) 813238 11 3 11 8 7 2 1 1 0 0 0.783 1.000 1.000 574 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 SNCAIP(5) 316142 5 3 5 5 5 0 0 0 0 0 0.884 1.000 1.000 575 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 20 MAP2K1(1), NFKB1(1), RAF1(1) 911491 3 3 3 4 1 0 0 2 0 0 0.980 1.000 1.000 576 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), PPARG(2), RXRA(1) 288484 4 3 4 5 3 1 0 0 0 0 0.894 1.000 1.000 577 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 GHR(1), NFKB1(1) 686780 2 2 2 3 1 0 0 1 0 0 0.967 1.000 1.000 578 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 IKBKAP(1), NFKB1(1), TRAF6(1) 883300 3 2 3 5 2 0 0 1 0 0 0.981 1.000 1.000 579 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 MYT1(2) 676263 2 2 2 4 2 0 0 0 0 0 0.979 1.000 1.000 580 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IL12A(1), IL6(1) 487624 2 2 2 5 0 0 1 1 0 0 0.989 1.000 1.000 581 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH7A1(2), ALDH9A1(1) 418868 3 2 3 5 2 1 0 0 0 0 0.945 1.000 1.000 582 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 CSAD(1), GAD2(1) 277421 2 2 2 3 1 0 1 0 0 0 0.927 1.000 1.000 583 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS2(2) 225646 2 2 2 4 2 0 0 0 0 0 0.970 1.000 1.000 584 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 DSE(3) 650159 3 2 3 7 3 0 0 0 0 0 0.978 1.000 1.000 585 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 FUT1(2), FUT2(1), FUT3(1) 357388 4 2 4 5 3 1 0 0 0 0 0.887 1.000 1.000 586 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 APOBEC1(1), APOBEC3A(1) 369383 2 2 2 3 2 0 0 0 0 0 0.925 1.000 1.000 587 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR2(1), JAK1(1) 533614 2 2 2 4 2 0 0 0 0 0 0.978 1.000 1.000 588 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 MDH1(1), OGDH(2) 470013 3 2 3 4 3 0 0 0 0 0 0.903 1.000 1.000 589 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 HDAC9(3), MEF2B(1) 356226 4 2 4 4 2 2 0 0 0 0 0.857 1.000 1.000 590 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ESR1(1), GREB1(1) 521063 2 2 2 6 1 0 1 0 0 0 0.995 1.000 1.000 591 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1), NOTCH1(1) 456274 2 2 2 5 1 0 1 0 0 0 0.986 1.000 1.000 592 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO2(1), TAT(1) 414027 2 2 2 3 1 1 0 0 0 0 0.901 1.000 1.000 593 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 8 ACO1(1), MDH1(1) 402279 2 2 2 4 2 0 0 0 0 0 0.964 1.000 1.000 594 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 FMOD(1), KERA(1) 171211 2 2 2 3 1 1 0 0 0 0 0.918 1.000 1.000 595 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 PRKCA(2) 462719 2 2 2 4 2 0 0 0 0 0 0.961 1.000 1.000 596 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 CREB5(2), RAF1(1) 549915 3 2 3 3 1 1 0 1 0 0 0.947 1.000 1.000 597 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 JAK1(1), PTPRU(2) 620803 3 2 3 3 3 0 0 0 0 0 0.860 1.000 1.000 598 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH9A1(1) 391741 1 1 1 5 0 1 0 0 0 0 0.996 1.000 1.000 599 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1) 266662 1 1 1 2 0 1 0 0 0 0 0.950 1.000 1.000 600 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH9A1(1) 391741 1 1 1 5 0 1 0 0 0 0 0.996 1.000 1.000 601 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 MST1R(1) 324819 1 1 1 7 1 0 0 0 0 0 0.999 1.000 1.000 602 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 JAK1(1), JAK2(1) 517273 2 1 2 3 1 0 0 1 0 0 0.957 1.000 1.000 603 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 JAK1(1), JAK2(1) 517273 2 1 2 3 1 0 0 1 0 0 0.957 1.000 1.000 604 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 327636 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 605 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 82686 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 606 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 195731 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 607 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 243817 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 608 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 25727 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 609 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 105566 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 610 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 154059 0 0 0 3 0 0 0 0 0 0 1.000 1.000 1.000 611 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 77610 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 612 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 191335 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 613 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 432200 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 614 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 156996 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 847907 0 0 0 4 0 0 0 0 0 0 1.000 1.000 1.000 616 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 370879 0 0 0 3 0 0 0 0 0 0 1.000 1.000 1.000