Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.022 0.096 -9999.0 0.0 -0.226 6.0 6.0 epithelial cell differentiation -0.023 0.103 -9999.0 0.0 -0.24 6.0 6.0 CYFIP2 -0.014 0.123 -9999.0 0.0 -0.493 2.0 2.0 ENAH 0.001 0.076 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.045 0.168 -9999.0 0.0 -0.493 4.0 4.0 EPHA2 0.014 0.015 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.029 0.102 -9999.0 0.0 -0.225 7.0 7.0 CTNNB1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.007 0.077 -9999.0 0.0 -0.29 2.0 2.0 AQP5 -0.052 0.165 -9999.0 0.0 -0.495 3.0 3.0 CTNND1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.021 0.095 -9999.0 0.0 -0.222 6.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.018 0.098 -9999.0 0.0 -0.223 6.0 6.0 EGF -0.056 0.187 -9999.0 0.0 -0.493 5.0 5.0 NCKAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.032 0.153 -9999.0 0.0 -0.529 2.0 2.0 cortical microtubule organization -0.023 0.103 -9999.0 0.0 -0.24 6.0 6.0 GO:0000145 -0.021 0.09 -9999.0 0.0 -0.212 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.021 0.104 -9999.0 0.0 -0.242 6.0 6.0 MLLT4 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.033 0.07 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.012 0.091 -9999.0 0.0 -0.206 6.0 6.0 PVRL2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.021 0.096 -9999.0 0.0 -0.225 6.0 6.0 ARF6/GTP 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.078 0.196 -9999.0 0.0 -0.493 6.0 6.0 EGFR/EGFR/EGF/EGF -0.094 0.164 -9999.0 0.0 -0.306 11.0 11.0 RhoA/GDP -0.02 0.096 -9999.0 0.0 -0.223 6.0 6.0 actin cytoskeleton organization -0.024 0.099 -9999.0 0.0 -0.215 7.0 7.0 IGF-1R heterotetramer 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.017 0.122 -9999.0 0.0 -0.493 2.0 2.0 DIAPH1 -0.027 0.138 -9999.0 0.0 -0.565 2.0 2.0 Wnt receptor signaling pathway 0.023 0.103 0.24 6.0 -9999.0 0.0 6.0 RHOA 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.034 0.071 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.025 0.101 -9999.0 0.0 -0.219 7.0 7.0 EFNA1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.016 0.092 -9999.0 0.0 -0.211 6.0 6.0 Ephrin A1/EPHA2 -0.036 0.085 -9999.0 0.0 -0.214 6.0 6.0 SEC6/SEC8 -0.035 0.075 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.018 0.099 -9999.0 0.0 -0.226 6.0 6.0 HGF/MET -0.068 0.124 -9999.0 0.0 -0.245 10.0 10.0 HGF 0.003 0.091 -9999.0 0.0 -0.493 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.023 0.097 -9999.0 0.0 -0.227 6.0 6.0 actin cable formation 0.009 0.074 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 -0.038 0.137 -9999.0 0.0 -0.282 7.0 7.0 KIFC3 -0.021 0.096 -9999.0 0.0 -0.225 6.0 6.0 NCK1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.014 0.015 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.021 0.096 -9999.0 0.0 -0.225 6.0 6.0 NCK1/GIT1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.023 0.103 -9999.0 0.0 -0.24 6.0 6.0 EXOC4 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.021 0.096 -9999.0 0.0 -0.225 6.0 6.0 PIP5K1C -0.021 0.096 -9999.0 0.0 -0.225 6.0 6.0 LIMA1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.005 0.086 -9999.0 0.0 -0.205 1.0 1.0 adherens junction assembly -0.031 0.139 -9999.0 0.0 -0.474 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.049 0.094 -9999.0 0.0 -0.214 8.0 8.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.045 0.168 -9999.0 0.0 -0.493 4.0 4.0 PLEKHA7 -0.036 0.123 -9999.0 0.0 -0.26 7.0 7.0 mol:GTP 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.002 0.086 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.022 0.096 -9999.0 0.0 -0.226 6.0 6.0 regulation of cell-cell adhesion -0.024 0.099 -9999.0 0.0 -0.215 7.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.023 0.097 -9999.0 0.0 -0.227 6.0 6.0