Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.02 0.081 -9999.0 0.0 -0.191 6.0 6.0 epithelial cell differentiation 0.014 0.084 -9999.0 0.0 -0.178 5.0 5.0 CYFIP2 0.012 0.099 0.185 2.0 -0.346 2.0 4.0 ENAH -0.046 0.046 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.009 0.131 0.185 2.0 -0.346 4.0 6.0 EPHA2 0.031 0.028 0.185 1.0 -9999.0 0.0 1.0 MYO6 -0.033 0.092 0.344 1.0 -9999.0 0.0 1.0 CTNNB1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.041 0.068 -9999.0 0.0 -0.198 2.0 2.0 AQP5 -0.046 0.175 0.471 1.0 -0.47 3.0 4.0 CTNND1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.031 0.088 0.342 1.0 -9999.0 0.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.017 0.09 0.342 1.0 -9999.0 0.0 1.0 EGF -0.018 0.146 0.185 3.0 -0.346 5.0 8.0 NCKAP1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.049 0.155 0.377 1.0 -0.36 4.0 5.0 cortical microtubule organization 0.014 0.084 -9999.0 0.0 -0.178 5.0 5.0 GO:0000145 -0.029 0.084 0.328 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.018 0.087 -9999.0 0.0 -0.18 5.0 5.0 MLLT4 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.052 0.052 -9999.0 0.0 -0.172 5.0 5.0 ARF6 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.061 0.023 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.018 0.085 0.336 1.0 -9999.0 0.0 1.0 PVRL2 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.031 0.089 0.344 1.0 -0.175 5.0 6.0 ARF6/GTP 0.067 0.025 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.027 0.138 0.185 1.0 -0.346 5.0 6.0 EGFR/EGFR/EGF/EGF -0.036 0.123 -9999.0 0.0 -0.207 10.0 10.0 RhoA/GDP 0.015 0.083 -9999.0 0.0 -0.174 5.0 5.0 actin cytoskeleton organization -0.033 0.09 0.326 1.0 -0.179 4.0 5.0 IGF-1R heterotetramer 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.009 0.094 0.185 1.0 -0.346 2.0 3.0 DIAPH1 -0.018 0.2 -9999.0 0.0 -0.578 3.0 3.0 Wnt receptor signaling pathway -0.014 0.084 0.178 5.0 -9999.0 0.0 5.0 RHOA 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.052 0.053 -9999.0 0.0 -0.173 5.0 5.0 CTNNA1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.034 0.091 0.328 1.0 -0.182 4.0 5.0 EFNA1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.03 0.088 0.334 1.0 -9999.0 0.0 1.0 Ephrin A1/EPHA2 0.007 0.08 -9999.0 0.0 -0.174 5.0 5.0 SEC6/SEC8 -0.047 0.056 -9999.0 0.0 -0.174 5.0 5.0 MGAT3 -0.017 0.091 0.344 1.0 -9999.0 0.0 1.0 HGF/MET -0.006 0.102 -9999.0 0.0 -0.169 8.0 8.0 HGF 0.03 0.081 0.185 3.0 -0.346 1.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.02 0.081 -9999.0 0.0 -0.192 6.0 6.0 actin cable formation -0.001 0.142 0.685 1.0 -0.252 1.0 2.0 KIAA1543 -0.033 0.094 0.331 1.0 -0.309 1.0 2.0 KIFC3 -0.033 0.087 0.344 1.0 -9999.0 0.0 1.0 NCK1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.031 0.089 0.344 1.0 -9999.0 0.0 1.0 NCK1/GIT1 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.014 0.084 -9999.0 0.0 -0.178 5.0 5.0 EXOC4 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.03 0.089 0.344 1.0 -9999.0 0.0 1.0 PIP5K1C -0.031 0.089 0.344 1.0 -9999.0 0.0 1.0 LIMA1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.026 0.126 0.596 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.046 0.121 0.386 1.0 -0.359 2.0 3.0 IGF-1R heterotetramer/IGF1 -0.006 0.091 -9999.0 0.0 -0.175 7.0 7.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.033 0.015 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.009 0.131 0.185 2.0 -0.346 4.0 6.0 PLEKHA7 -0.034 0.099 0.344 1.0 -0.324 1.0 2.0 mol:GTP 0.059 0.022 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.019 0.117 0.463 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization -0.02 0.081 -9999.0 0.0 -0.191 6.0 6.0 regulation of cell-cell adhesion -0.033 0.09 0.326 1.0 -0.179 4.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.02 0.081 -9999.0 0.0 -0.192 6.0 6.0