rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CDKN2A(2), E2F1(1), PRB1(5), TP53(2)	422815	10	6	10	3	4	0	1	1	4	0	0.342	0.00149	0.916
2	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	SP1(2), TP53(2)	351795	4	4	4	1	0	0	2	1	1	0	0.690	0.0252	1.000
3	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), MARS(3), MAT1A(2), PAPSS1(1), PAPSS2(3), SCLY(1)	615278	11	7	11	2	7	2	0	1	1	0	0.0773	0.0549	1.000
4	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNE1(1), CCNE2(3), CDKN2A(2), E2F1(1), PRB1(5)	448780	12	8	11	3	5	0	0	4	3	0	0.274	0.0551	1.000
5	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), EHHADH(2), HADHA(2), SDS(1)	240462	6	5	6	0	5	0	0	0	1	0	0.0445	0.0651	1.000
6	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGTR1(2), AGTR2(1), BDKRB2(3), KNG1(1), NOS3(3), REN(2)	489373	14	8	14	4	6	0	1	4	3	0	0.131	0.0724	1.000
7	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(2), CRY1(2), PER1(1)	417978	5	4	4	0	1	1	0	1	2	0	0.350	0.0817	1.000
8	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(3), CD38(2), ENPP1(1), ENPP3(1), NADSYN1(2), NNMT(1), NT5E(1), QPRT(1)	714118	12	7	12	2	7	1	0	2	2	0	0.132	0.0835	1.000
9	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(3), NR1H4(2), RXRA(1)	270174	6	4	6	1	3	2	1	0	0	0	0.167	0.0868	1.000
10	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(2)	111602	3	3	3	2	1	1	1	0	0	0	0.750	0.0929	1.000
11	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	15	CDKN2A(2), E2F1(1), POLR1A(2), POLR1B(1), RB1(1), TP53(2)	980254	9	8	9	3	3	0	1	1	4	0	0.447	0.0962	1.000
12	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(1), BAX(1), BCL2(1), CCNE1(1), E2F1(1), RB1(1), TP53(2)	883898	8	7	8	1	3	0	2	0	3	0	0.250	0.0985	1.000
13	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD34(1), CD3D(1), IL6(1)	302696	4	4	4	1	1	0	1	0	2	0	0.352	0.130	1.000
14	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	RB1(1), SP1(2)	328596	3	3	3	1	0	0	1	1	1	0	0.639	0.132	1.000
15	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	JAK2(1), LIN7A(1), NFKB1(1), RB1(1), TP53(2), USH1C(4)	885827	10	8	10	3	3	0	1	3	3	0	0.493	0.135	1.000
16	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1), SLPI(1)	85455	2	2	2	0	0	1	0	1	0	0	0.532	0.136	1.000
17	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(2), ITGA4(1), ITGAL(2), ITGAM(3), SELE(9), SELP(1)	760406	18	7	18	4	14	0	0	1	3	0	0.0911	0.145	1.000
18	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(2), ITGAL(2), ITGAM(3), SELE(9)	497480	16	6	16	3	13	0	0	1	2	0	0.0342	0.148	1.000
19	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	HLA-DRA(2)	116716	2	2	2	0	2	0	0	0	0	0	0.312	0.152	1.000
20	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(2), MAP2K1(1), RAF1(1)	401384	4	4	4	1	0	1	0	2	1	0	0.469	0.160	1.000
21	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(1), PLCB1(3), PRKCA(2)	401203	7	7	7	3	5	0	0	2	0	0	0.631	0.164	1.000
22	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(1)	90631	1	1	1	1	0	1	0	0	0	0	0.860	0.170	1.000
23	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	17	ARPC1B(3), NCKAP1(1), NTRK1(4)	732085	8	7	8	2	3	0	2	2	1	0	0.457	0.172	1.000
24	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT2(2), MAP2K1(1), NTRK1(4), PIK3CD(1), SOS1(1)	780886	9	7	9	2	2	0	1	3	3	0	0.573	0.179	1.000
25	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(1), SRP54(1), SRP68(2)	382094	5	4	5	0	2	0	1	1	1	0	0.189	0.181	1.000
26	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(2), GBA3(1), SHMT2(1)	263675	5	4	5	1	5	0	0	0	0	0	0.202	0.200	1.000
27	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(2), CD3D(1)	159157	3	2	3	1	1	1	0	0	1	0	0.446	0.200	1.000
28	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	HLA-DRA(2)	148998	2	2	2	1	2	0	0	0	0	0	0.565	0.213	1.000
29	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(1), CASP8(1), CFLAR(1)	195346	3	2	3	1	1	0	0	1	1	0	0.784	0.219	1.000
30	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(3), DAXX(2), PAX3(1), RB1(1), SP100(2), TP53(2)	921061	11	8	11	4	5	0	3	1	2	0	0.460	0.243	1.000
31	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(2), ITGA4(1), ITGAL(2), SELE(9)	577706	14	6	14	2	10	0	0	1	3	0	0.0774	0.244	1.000
32	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), BHMT(2), DNMT3B(2), MARS(3), MAT1A(2), MTAP(1), MTFMT(1), TAT(1)	1041401	13	6	13	4	8	1	1	2	1	0	0.201	0.249	1.000
33	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), EHHADH(2), HADHA(2), SDS(1)	415003	6	5	6	1	5	0	0	0	1	0	0.189	0.252	1.000
34	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1)	55390	1	1	1	1	0	0	0	0	1	0	0.873	0.261	1.000
35	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	ABP1(4), AOC2(1), CES1(5), DDHD1(3), LIPA(3), MYST3(4), MYST4(5), PLA1A(2), PNPLA3(1), PPME1(1)	1253489	29	11	29	8	17	3	2	3	4	0	0.0848	0.262	1.000
36	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(4), AOC2(1), CES1(5), ESD(1)	296797	11	6	11	2	9	1	1	0	0	0	0.0570	0.268	1.000
37	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	NFKB1(1), TP53(2)	476878	3	3	3	0	1	0	1	0	1	0	0.437	0.268	1.000
38	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(2), CRY1(2), CSNK1D(1), PER1(1), PER2(2), PER3(1)	842627	9	7	8	2	3	1	0	2	3	0	0.502	0.276	1.000
39	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCND3(1), CCNE1(1), CDKN2A(2), E2F1(1), RB1(1)	802915	6	6	6	1	3	0	0	0	3	0	0.198	0.288	1.000
40	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	EIF4EBP1(1), IGF1(1), IGF1R(4), INPPL1(1), PTEN(1), RPS6KB1(1)	969601	9	6	9	1	4	1	1	2	1	0	0.168	0.290	1.000
41	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BAX(1), BCL2(1), CES1(5)	526714	8	6	8	2	5	1	1	0	1	0	0.369	0.292	1.000
42	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	HLA-DRA(2)	194043	2	2	2	0	2	0	0	0	0	0	0.305	0.304	1.000
43	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ANKRD1(1), EIF4EBP1(1), IL1R1(2), JUND(1), NR4A3(2)	521526	7	6	7	3	5	0	1	1	0	0	0.536	0.307	1.000
44	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(1), ACOX3(4), PLA2G2A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2)	500476	12	6	12	5	7	1	0	0	4	0	0.364	0.311	1.000
45	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(3), CD38(2), ENPP1(1), ENPP3(1), NADK(1), NADSYN1(2), NNMT(1), NT5C1B(4), NT5E(1), QPRT(1)	1057766	17	7	17	4	11	1	1	2	2	0	0.143	0.314	1.000
46	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(1), LPO(3), MPO(3), PRDX1(2), SHMT2(1), TPO(3)	587393	14	9	14	7	10	0	0	2	2	0	0.408	0.321	1.000
47	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	35575	1	1	1	0	1	0	0	0	0	0	0.608	0.322	1.000
48	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	EIF4A1(1), EIF4EBP1(1), EIF4G1(1), EIF4G2(2), EIF4G3(1), FKBP1A(1), PTEN(1), RPS6KB1(1), TSC1(1), TSC2(1)	1368303	11	8	11	2	5	1	2	2	1	0	0.190	0.344	1.000
49	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), HEMK1(1), MARS(3), MAT1A(2), METTL2B(2), METTL6(1), PAPSS1(1), PAPSS2(3), PRMT5(1), PRMT8(2), SCLY(1)	1238244	18	9	18	4	13	3	0	1	1	0	0.0446	0.362	1.000
50	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	CCNE1(1), CDKN2A(2), E2F1(1), RB1(1), SKP2(1), TP53(2)	1484464	8	8	8	3	3	0	1	0	4	0	0.505	0.362	1.000
51	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), GPI(2), PKLR(3)	452982	6	5	6	1	4	0	1	0	1	0	0.124	0.367	1.000
52	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	IL12A(1)	142826	1	1	1	0	0	0	0	1	0	0	0.854	0.381	1.000
53	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	CHEK2(1), TP53(2)	784020	3	3	3	1	0	1	1	0	1	0	0.760	0.384	1.000
54	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), EHHADH(2), HADHA(2), HSD17B4(1), NTAN1(1), VNN2(3)	584931	10	6	10	0	8	0	0	2	0	0	0.0183	0.388	1.000
55	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	GPR109B(3), GPR161(1), GPR171(1), GPR39(1)	480655	6	3	6	3	3	0	1	2	0	0	0.489	0.391	1.000
56	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	CAT(1), GHR(1), IGF1(1), IGF1R(4)	653384	7	5	7	1	4	1	0	2	0	0	0.216	0.392	1.000
57	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), HDC(2), TPH1(1)	293593	4	3	4	1	3	0	0	0	1	0	0.286	0.395	1.000
58	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT2(1), EXTL3(1), GLCE(2), HS3ST1(1), HS3ST2(1), HS3ST3A1(1), HS3ST3B1(1), HS6ST2(1), HS6ST3(2), NDST1(2), NDST3(3), NDST4(4)	998847	20	7	20	1	14	1	1	2	2	0	0.000769	0.396	1.000
59	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	EHHADH(2), HADHA(2), SDS(1)	387362	5	4	5	0	4	0	0	0	1	0	0.0867	0.397	1.000
60	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), FYN(1), THBS1(1)	364331	3	3	3	5	0	0	1	0	2	0	0.990	0.398	1.000
61	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), HMBS(1), PPOX(1), UROS(1)	376416	4	4	4	0	2	1	0	0	1	0	0.152	0.413	1.000
62	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(1), SHMT2(1)	199500	2	2	2	2	2	0	0	0	0	0	0.766	0.414	1.000
63	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	11	ARPC1B(3)	379543	3	3	3	1	2	0	1	0	0	0	0.572	0.416	1.000
64	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	IGF1R(4), IRS1(1), MAP2K1(1), RAF1(1), SOS1(1)	938594	8	6	8	1	3	1	0	4	0	0	0.230	0.421	1.000
65	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(4), BAX(1), CSNK1D(1), MAPK8(1), TP53(2)	1019939	9	6	9	3	3	1	1	1	3	0	0.667	0.421	1.000
66	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOB(1), ALDOC(1)	196835	2	2	2	1	2	0	0	0	0	0	0.669	0.427	1.000
67	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPP(1), ALPPL2(2), SPR(1)	312944	5	3	5	2	3	2	0	0	0	0	0.363	0.428	1.000
68	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), FYN(1), HLA-DRA(2), LCK(1), PTPRC(2)	431159	7	4	7	2	5	0	0	0	2	0	0.335	0.435	1.000
69	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(1), ADORA3(2), P2RY1(2)	297078	5	4	5	4	3	1	0	1	0	0	0.561	0.435	1.000
70	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(2), FUT2(1), FUT9(2), GLA(1), HEXA(1), ST3GAL1(1)	498132	8	5	8	2	5	0	0	3	0	0	0.260	0.437	1.000
71	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	39	CLOCK(2), CRY1(2), EIF4G2(2), ETV6(2), GFRA1(2), HERPUD1(1), KLF9(1), MYF6(2), NCKAP1(1), NR1D2(1), PER1(1), PER2(2), PURA(1), SF3A3(1), TUBB3(2), ZFR(1)	1795446	24	13	23	8	10	1	2	7	4	0	0.557	0.437	1.000
72	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	BCL2(1), EGFR(3), IGF1R(4), POLR2A(2), PRKCA(2), RB1(1), TEP1(2), TERT(2), TP53(2)	1393676	19	10	19	6	13	0	1	3	2	0	0.197	0.437	1.000
73	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(1), PAPSS2(3), SULT2A1(1), SUOX(2)	300728	7	3	7	1	6	1	0	0	0	0	0.158	0.443	1.000
74	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(1), IL6R(1), JAK1(1), JAK2(1), JAK3(1), PTPRU(2), STAT3(3)	750978	10	5	10	2	5	1	2	1	1	0	0.128	0.445	1.000
75	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(3)	238847	3	3	3	2	2	0	0	1	0	0	0.785	0.464	1.000
76	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA4(1), NDUFB2(1), NDUFB6(1)	348016	3	3	3	0	2	0	0	1	0	0	0.360	0.469	1.000
77	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), CREBBP(3), DFFA(1), DFFB(1), GZMA(1), PRF1(3)	525713	10	5	10	2	5	1	2	1	1	0	0.193	0.474	1.000
78	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), BHMT(2), DNMT3B(2), MARS(3), MAT1A(2)	877461	10	5	10	2	6	1	1	2	0	0	0.148	0.478	1.000
79	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(1), PRKCA(2), TGM2(2)	247644	5	3	5	1	5	0	0	0	0	0	0.152	0.480	1.000
80	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT2(2), BRD4(2), CBL(1), CDKN2A(2), IGFBP1(1), INPPL1(1), IRS1(1), IRS4(2), PARD3(2), PIK3CD(1), PPYR1(1), PTEN(1), PTPN1(1), RAF1(1), RPS6KA2(1), RPS6KB1(1), SLC2A4(1), SORBS1(1), SOS1(1), SOS2(2)	2939426	26	15	26	9	10	2	2	5	7	0	0.380	0.488	1.000
81	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(2), F13B(1), HSD17B4(1), HSD3B1(1), HSD3B2(1)	388450	6	4	6	1	6	0	0	0	0	0	0.157	0.492	1.000
82	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(1), EGF(3), EGFR(3), MAP2K1(1), PTPRB(10), RAF1(1), SOS1(1), SPRY1(2), SPRY3(1)	1222812	23	10	23	6	17	0	2	3	1	0	0.124	0.494	1.000
83	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(2), IMPDH1(1), MTHFD2(1), POLG(1), PRPS2(1)	613397	6	4	6	1	3	0	0	2	1	0	0.253	0.500	1.000
84	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS3(1), DHRSX(1), MYST3(4), MYST4(5), PNPLA3(1)	826655	12	6	12	3	5	1	1	3	2	0	0.300	0.502	1.000
85	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), BIRC3(1), CASP8(1), DFFA(1), DFFB(1), LMNA(3), LMNB2(1), PRF1(3)	966308	12	7	12	4	4	2	2	3	1	0	0.469	0.503	1.000
86	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	11	ALAD(1), HBB(1), HMBS(1), UROS(1)	376852	4	3	4	1	2	1	0	0	1	0	0.359	0.512	1.000
87	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(2), CYP2C9(3)	98638	5	3	5	3	5	0	0	0	0	0	0.607	0.515	1.000
88	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	CPEB1(1), EGFR(3), ERBB4(6), ETS2(1), ETV6(2), FMN2(5), KRAS(3), MAP2K1(1), NOTCH1(1), NOTCH2(11), NOTCH3(4), NOTCH4(8), PIWIL1(4), PIWIL2(1), PIWIL3(3), RAF1(1), SOS1(1), SOS2(2), SPIRE2(1)	2593598	59	14	59	18	36	2	2	16	3	0	0.102	0.515	1.000
89	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	MAP2K1(1), MAP2K6(1), NFKB1(1), RB1(1), SP1(2)	942083	6	6	6	2	2	0	1	2	1	0	0.548	0.524	1.000
90	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLE(2), POLG(1), POLL(1), POLQ(2)	826792	6	5	6	2	1	1	0	2	2	0	0.597	0.525	1.000
91	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), E2F1(1), FBXW7(1), RB1(1)	397742	4	3	4	0	2	0	0	0	2	0	0.218	0.533	1.000
92	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	HMGCR(3), SC5DL(1)	543522	4	4	3	3	1	0	0	1	2	0	0.876	0.534	1.000
93	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ARPC1B(3), PDGFRA(4)	643294	7	5	7	1	6	0	1	0	0	0	0.185	0.537	1.000
94	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(1), CYP2E1(2), NR1I3(1), PTGS2(2)	269257	6	5	6	4	4	0	0	1	1	0	0.647	0.541	1.000
95	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNE1(1), E2F1(1), RB1(1), SKP2(1)	419911	4	4	4	0	3	0	0	0	1	0	0.152	0.558	1.000
96	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	GBA3(1), LPO(3), MPO(3), PRDX1(2), TPO(3)	476515	12	7	12	6	9	0	0	1	2	0	0.456	0.562	1.000
97	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BIRC3(1), CASP8(1), TRAF2(1)	405276	3	3	3	2	2	0	0	0	1	0	0.834	0.564	1.000
98	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	IL6(1), LDLR(3)	266317	4	3	4	3	3	0	1	0	0	0	0.741	0.564	1.000
99	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA4(1), ANXA6(1), CYP11A1(1), EDN1(2), HSD11B1(1), PLA2G4A(3), PTGDR(3), PTGER2(1), PTGFR(4), PTGIR(1), PTGS2(2)	1002943	20	6	20	6	16	1	1	0	2	0	0.0591	0.565	1.000
100	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CAPNS1(1), CSNK1D(1), MAPT(1)	439505	4	3	4	2	2	0	0	0	2	0	0.684	0.566	1.000
101	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), E2F1(1), RB1(1), SKP2(1)	424718	4	4	4	0	3	0	0	0	1	0	0.151	0.567	1.000
102	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	HADHA(2), HSD17B4(1), PPT2(2)	420644	5	5	5	2	3	0	0	2	0	0	0.629	0.568	1.000
103	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	COPA(3), GBF1(1), GPLD1(1)	816489	5	4	5	2	2	2	0	0	1	0	0.451	0.577	1.000
104	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(1), MTFMT(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1), MTHFR(1), SHMT2(1)	941393	9	4	9	1	6	2	0	0	1	0	0.0608	0.581	1.000
105	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	CASP8(1), INSR(7), ITCH(2), MAGI1(1), MAGI2(5), RERE(4), WWP2(1)	1189734	21	9	21	4	13	4	1	2	1	0	0.0603	0.593	1.000
106	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	GNAQ(1)	294952	1	1	1	1	0	0	0	1	0	0	0.922	0.597	1.000
107	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(1), BAX(1), BCL2(1), BIRC3(1), CASP8(1), DFFA(1), DFFB(1)	670372	7	4	7	3	2	0	2	1	2	0	0.772	0.600	1.000
108	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(2), FYN(1), RELN(11)	680722	14	7	14	7	10	0	0	2	2	0	0.722	0.606	1.000
109	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2)	575951	2	2	2	0	0	0	0	0	2	0	0.845	0.609	1.000
110	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), CP(1), HMBS(1), PPOX(1), UGT1A10(3), UGT1A3(1), UGT1A4(3), UGT1A5(1), UGT2B15(4), UGT2B4(2), UROS(1)	1364339	19	9	19	6	10	1	5	1	2	0	0.152	0.616	1.000
111	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	IL6(1)	298261	1	1	1	1	0	0	1	0	0	0	0.880	0.619	1.000
112	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT1(2), FUT2(1), FUT9(2)	294492	5	4	5	2	4	0	0	1	0	0	0.441	0.626	1.000
113	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(1), CYP2A13(2), CYP2A6(2), CYP2A7(1), NAT2(1), XDH(9)	399469	16	6	16	5	14	0	0	1	1	0	0.0411	0.627	1.000
114	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(2), ACTN2(5), ACTN3(2), BCAR1(1), BCR(2), CAPNS1(1), CRKL(1), FYN(1), MAP2K1(1), MAPK8(1), PTK2(2), PXN(1), RAF1(1), SOS1(1), TLN1(1), ZYX(1)	2292199	24	10	23	7	10	4	0	5	5	0	0.183	0.637	1.000
115	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	HMGCR(3), SC4MOL(1), SC5DL(1)	650120	5	5	4	4	2	0	0	1	2	0	0.886	0.640	1.000
116	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ACOX1(1), ACOX3(4), FASN(2), HADHA(2)	708001	10	6	10	1	8	0	0	0	2	0	0.0150	0.643	1.000
117	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA2(2), POLE(2), POLG(1), POLG2(1), POLL(1), POLM(1), POLQ(2), PRIM1(1), PRIM2(3), REV1(1), REV3L(2)	1992498	17	9	17	4	9	1	0	3	4	0	0.232	0.651	1.000
118	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	LDHA(1), LDHAL6B(3), MPST(1), SDS(1), SULT1B1(1), SULT1C4(1)	623945	8	4	8	2	4	0	1	0	3	0	0.197	0.665	1.000
119	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(1), UGT1A10(3), UGT1A3(1), UGT1A4(3), UGT1A5(1), UGT2B15(4), UGT2B4(2)	873035	15	8	15	7	8	0	5	1	1	0	0.417	0.668	1.000
120	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(2), ACTN2(5), ACTN3(2), BCAR1(1), CTNNA2(4), CTNNB1(1), PTK2(2), PXN(1)	927159	18	8	17	4	12	3	0	2	1	0	0.0426	0.673	1.000
121	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	KARS(1)	225603	1	1	1	1	1	0	0	0	0	0	0.893	0.683	1.000
122	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(4), ABCB11(9), ABCB4(2), ABCC3(3)	691694	18	6	18	9	14	2	0	1	1	0	0.273	0.683	1.000
123	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACOT11(2), DHRS3(1), DHRSX(1), EHHADH(2), HADHA(2), MYST3(4), MYST4(5), PNPLA3(1)	1293261	18	7	18	3	11	1	1	3	2	0	0.0527	0.695	1.000
124	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(1), GNAQ(1), PLCB1(3), TUB(1)	351655	6	5	6	4	4	0	0	2	0	0	0.796	0.700	1.000
125	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(1)	239591	1	1	1	0	0	0	1	0	0	0	0.751	0.707	1.000
126	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	DMC1(2), EGR1(2), FSHR(2), INHA(1), LHCGR(2), MLH1(3), MSH5(2), NCOR1(4), NRIP1(1), PGR(1), PRLR(1), PTGER2(1), ZP2(1)	1704981	23	10	23	4	15	2	0	3	3	0	0.0422	0.710	1.000
127	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC2(1), ABCG2(1), BCHE(1), CES1(5), CYP3A4(3), CYP3A5(1), UGT1A10(3), UGT1A3(1), UGT1A4(3), UGT1A5(1)	1128038	20	9	20	9	12	1	5	0	2	0	0.286	0.713	1.000
128	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1)	250456	1	1	1	1	0	0	0	1	0	0	0.946	0.715	1.000
129	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS3(1), DHRSX(1), HEMK1(1), METTL2B(2), METTL6(1), PRMT5(1), PRMT8(2)	746303	9	5	9	1	7	1	0	1	0	0	0.0586	0.718	1.000
130	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	EIF4A1(1), EIF4EBP1(1), EIF4G1(1), EIF4G2(2), EIF4G3(1), GHR(1), IRS1(1), PABPC1(1), PRKCA(2), PTEN(1), RPS6KB1(1)	1399886	13	8	13	4	6	1	1	3	2	0	0.449	0.723	1.000
131	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(1), CYP11B2(2), CYP17A1(2), HSD11B1(1), HSD3B1(1), HSD3B2(1)	339015	9	4	9	5	8	0	0	0	1	0	0.246	0.724	1.000
132	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(6), PRKCA(2)	439742	8	5	8	2	7	0	0	1	0	0	0.272	0.725	1.000
133	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(1), EGF(3), EGFR(3), TF(1)	632797	8	6	8	6	6	0	0	0	2	0	0.838	0.728	1.000
134	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	NTRK1(4), PRKCA(2), SOS1(1)	765159	7	5	7	3	3	0	1	2	1	0	0.700	0.729	1.000
135	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(1), GABRA2(1), GABRA4(1), GABRA6(5), GPX1(1)	375591	9	5	8	5	6	1	1	1	0	0	0.624	0.734	1.000
136	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(4), ACO1(1), ACSS2(2), IDH1(3), MDH1(1)	662920	11	6	10	5	8	0	0	3	0	0	0.442	0.743	1.000
137	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(1), LPO(3), MPO(3), MTHFR(1), SHMT2(1), TPO(3)	580769	13	7	13	5	10	0	0	2	1	0	0.213	0.743	1.000
138	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(2), EEF2(1), EIF2AK3(2), EIF2B1(2), EIF2B3(2), EIF4A1(1), EIF4EBP1(1), EIF4G1(1), EIF4G3(1), ETF1(1), GSPT2(1), KIAA0664(1), PABPC1(1), PABPC3(2), PAIP1(2)	2167856	21	12	20	6	11	1	1	1	7	0	0.248	0.744	1.000
139	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	GNAQ(1), GNAS(3), MAP2K1(1), NOX1(1), PIK3C2G(4), PLCB1(3), PRKCA(2), PTK2(2), RAF1(1), ROCK2(1)	1225769	19	9	19	7	13	0	0	5	1	0	0.414	0.744	1.000
140	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	FUT1(2), FUT2(1), FUT9(2), GLA(1), HEXA(1), ST3GAL1(1)	529142	8	5	8	4	5	0	0	3	0	0	0.566	0.748	1.000
141	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(2), DPYD(4), ENPP1(1), ENPP3(1), PANK1(1), PANK4(1)	679943	11	7	11	4	9	0	0	2	0	0	0.435	0.756	1.000
142	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11A1(1), CYP11B1(1), CYP11B2(2), CYP17A1(2), CYP21A2(2), HSD11B1(1), HSD3B1(1), HSD3B2(1)	480428	12	5	12	6	10	1	0	1	0	0	0.261	0.761	1.000
143	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11A1(1), CYP11B1(1), CYP11B2(2), CYP17A1(2), CYP21A2(2), HSD11B1(1), HSD3B1(1), HSD3B2(1)	480428	12	5	12	6	10	1	0	1	0	0	0.261	0.761	1.000
144	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA5(1), PSMA6(1), PSMD14(1), RPN2(1), UBE3A(1)	643716	6	3	6	1	4	0	0	2	0	0	0.306	0.765	1.000
145	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	CD3D(1), ITGAL(2), PRF1(3)	430073	6	3	6	3	3	1	0	0	2	0	0.404	0.769	1.000
146	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSS(1), NFKB1(1), NOX1(1), XDH(9)	485726	13	5	13	5	11	1	0	0	1	0	0.184	0.770	1.000
147	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	IL2RG(1), IRS1(1), JAK1(1), JAK3(1), RPS6KB1(1), STAT6(1)	733147	6	5	6	3	3	2	1	0	0	0	0.566	0.774	1.000
148	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AP2A1(1), AP2M1(1), DNM1(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), SYNJ1(2), SYNJ2(3), SYT1(2)	1048009	13	7	13	4	9	1	0	2	1	0	0.253	0.778	1.000
149	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), BCL2(1), CASP8(1), MAP2K1(1), MAPK8(1), NFKB1(1), RAF1(1), TRAF2(1)	998717	8	5	8	2	3	0	0	3	2	0	0.565	0.783	1.000
150	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1), MTHFR(1), SHMT2(1)	889881	8	3	8	2	6	2	0	0	0	0	0.202	0.784	1.000
151	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	OXCT1(1)	165729	1	1	1	0	1	0	0	0	0	0	0.655	0.790	1.000
152	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	SEC22B(1), STX16(2), STX2(2), STX3(1), VTI1A(1), VTI1B(1)	813428	8	6	8	2	6	1	0	1	0	0	0.194	0.791	1.000
153	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), BIRC3(1), CASP8(1), DFFA(1), DFFB(1), PRF1(3), SCAP(1), SREBF2(1)	904384	10	6	10	4	3	2	3	1	1	0	0.524	0.793	1.000
154	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB27A(1), RAB3A(2)	207965	3	2	3	0	3	0	0	0	0	0	0.234	0.795	1.000
155	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	BCMO1(1)	192446	1	1	1	1	1	0	0	0	0	0	0.827	0.796	1.000
156	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(3), EGFR(3), NRG1(3)	511323	9	6	9	6	8	0	0	0	1	0	0.813	0.797	1.000
157	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	KEAP1(1), MAPK8(1), PRKCA(2)	432229	4	3	4	2	3	0	0	1	0	0	0.652	0.799	1.000
158	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	GARS(1), HARS(1), IARS(2), KARS(1), LARS(2), MARS(3), NARS(1), QARS(2), RARS(2), SARS(2)	1596901	17	10	17	7	12	2	0	2	1	0	0.345	0.799	1.000
159	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	IDI2(1)	209933	1	1	1	0	1	0	0	0	0	0	0.616	0.813	1.000
160	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	IL6(1), IL6R(1), IL6ST(1), JAK1(1), JAK2(1), JAK3(1), MAP2K1(1), PTPN11(1), RAF1(1), SOS1(1), STAT3(3)	1164666	13	9	13	5	4	1	2	5	1	0	0.512	0.816	1.000
161	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG7(2), IFNA14(1), IFNA16(1), IFNA6(1), IFNA7(1), PIK3R4(2), PRKAA2(1), ULK1(1)	1030270	10	6	10	4	4	3	1	2	0	0	0.467	0.818	1.000
162	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	HADHA(2)	271079	2	2	2	0	2	0	0	0	0	0	0.394	0.822	1.000
163	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS3(1), DHRSX(1)	448293	2	2	2	1	1	0	0	1	0	0	0.770	0.823	1.000
164	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(2), FUT2(1), FUT3(1)	248200	4	2	4	3	3	1	0	0	0	0	0.625	0.824	1.000
165	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	TAT(1)	129885	1	1	1	0	1	0	0	0	0	0	0.587	0.830	1.000
166	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	MYT1(2), RB1(1), TP53(2)	863944	5	5	5	4	2	0	1	0	2	0	0.900	0.830	1.000
167	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(2), AMY2A(1), AMY2B(1), ENPP1(1), ENPP3(1), GAA(1), GBA3(1), GBE1(1), GCK(5), GPI(2), GYS1(1), GYS2(2), HK2(1), HK3(3), MGAM(12), PYGB(1), PYGM(1), SI(8), UGT1A10(3), UGT1A3(1), UGT1A4(3), UGT1A5(1), UGT2B15(4), UGT2B4(2)	2759161	59	11	58	20	41	5	6	3	4	0	0.0305	0.835	1.000
168	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	KARS(1)	337249	1	1	1	1	1	0	0	0	0	0	0.900	0.837	1.000
169	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(3), RANGAP1(1)	423652	4	3	4	2	3	0	0	0	1	0	0.796	0.846	1.000
170	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), HMGCR(3), IDI2(1), SC4MOL(1), SC5DL(1)	953380	7	5	6	5	4	0	0	1	2	0	0.798	0.852	1.000
171	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	15	ACTN1(2), ACTN2(5), ACTN3(2), CAPNS1(1), PTK2(2), PXN(1), SPTAN1(2), TLN1(1)	1369063	16	7	15	3	11	1	0	1	3	0	0.0189	0.853	1.000
172	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(1), GABRA1(1), GABRA2(1), GABRA4(1), GABRA6(5), NSF(1), UBQLN1(1)	571978	11	7	10	5	8	0	2	1	0	0	0.470	0.855	1.000
173	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), BCAT2(1), COASY(2), DPYD(4), ENPP1(1), ENPP3(1), PANK1(1), PANK4(1), VNN1(1)	843454	13	7	13	4	11	0	0	2	0	0	0.259	0.856	1.000
174	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	APAF1(1), BCL2(1), DAXX(2), FAS(1), FASLG(3), MAPKAPK3(1)	565223	9	6	9	8	5	0	1	1	2	0	0.911	0.861	1.000
175	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(4), AGTR2(1), EDN1(2), EGF(3), EGFR(3), NFKB1(1), PRKCA(2)	1014161	16	9	16	7	14	0	0	1	1	0	0.335	0.862	1.000
176	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	PTK2B(2), SOS1(1)	432481	3	2	3	2	2	0	0	1	0	0	0.796	0.864	1.000
177	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD3D(1), ITGAL(2), PTPRC(2)	520205	6	3	6	4	3	0	0	0	3	0	0.604	0.865	1.000
178	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), PDE1A(3), PDE1B(2), PLCB1(3)	535603	9	7	9	5	7	0	0	2	0	0	0.630	0.873	1.000
179	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	RECK(1), TIMP2(1)	366009	2	2	2	2	1	0	0	1	0	0	0.893	0.877	1.000
180	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACSL3(1), CPT1A(3), EHHADH(2), HADHA(2)	841044	8	5	8	2	7	0	0	0	1	0	0.263	0.880	1.000
181	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD3D(1), ITGAL(2), PTPRC(2)	545776	6	3	6	4	3	0	0	0	3	0	0.597	0.882	1.000
182	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(1), SLC18A3(1)	341277	3	2	3	4	2	0	0	0	1	0	0.893	0.887	1.000
183	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(2), AXIN1(2), BTRC(1), CTNNB1(1), DLL1(1), FZD1(1), NOTCH1(1)	1031681	9	8	9	9	4	1	1	1	2	0	0.974	0.888	1.000
184	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(2), IGF1(1), IL6(1)	406195	4	4	4	3	2	1	1	0	0	0	0.798	0.889	1.000
185	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	APAF1(1), BAX(1), BCL2(1), PRKCA(2), PTK2(2), PXN(1), TLN1(1), TP53(2)	1346512	11	7	11	6	5	0	2	1	3	0	0.752	0.892	1.000
186	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP8(1), CFLAR(1), DAXX(2), DFFA(1), DFFB(1), FAF1(1), LMNA(3), LMNB2(1), MAPK8(1), PAK2(1), PTPN13(1), RB1(1), SPTAN1(2)	2003260	17	9	17	5	6	1	1	7	2	0	0.401	0.892	1.000
187	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	LDHA(1), MPST(1)	340912	2	2	2	0	2	0	0	0	0	0	0.370	0.894	1.000
188	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	IL10RA(1), IL6(1), JAK1(1), STAT3(3)	604730	6	4	6	4	2	0	2	0	2	0	0.706	0.896	1.000
189	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(1)	162037	1	1	1	0	1	0	0	0	0	0	0.538	0.897	1.000
190	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(2), F2(1), F2R(1), FGA(3), FGB(1), PLG(1), SERPINB2(3), SERPINE1(1)	656945	13	4	13	4	9	1	0	2	1	0	0.278	0.897	1.000
191	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), BCL2(1), BIRC3(1), CASP8(1), CFLAR(1), DFFA(1), DFFB(1), LMNA(3), NFKB1(1), SPTAN1(2), TNFRSF10B(1), TNFRSF25(1), TNFSF10(1), TRAF2(1)	1653162	17	9	17	7	8	2	2	4	1	0	0.472	0.898	1.000
192	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	CASP8(1), DFFA(1), DFFB(1), LMNA(3), LMNB2(1), MADD(2), MAPK8(1), PAK2(1), RB1(1), SPTAN1(2), TRAF2(1)	1915550	15	8	15	6	7	1	1	4	2	0	0.499	0.899	1.000
193	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	GBA(2), GBA3(1), LPO(3), MPO(3), TPO(3)	414211	12	5	12	5	10	0	0	1	1	0	0.247	0.903	1.000
194	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3D(1), CD86(1), HLA-DRA(2), ICOS(1), ITK(3), LCK(1), PTPN11(1)	627922	10	5	10	3	8	0	0	0	2	0	0.277	0.905	1.000
195	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	INSR(7), IRS1(1), MAP2K1(1), MAPK8(1), PTPN11(1), RAF1(1), SLC2A4(1), SOS1(1)	1258977	14	8	14	4	6	3	0	5	0	0	0.290	0.910	1.000
196	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	JAK1(1), JAK2(1)	401797	2	1	2	1	1	0	0	1	0	0	0.804	0.912	1.000
197	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	IGF1(1), IGF1R(4), IRS1(1), MAP2K1(1), MAPK8(1), PTPN11(1), RAF1(1), SOS1(1)	1215093	11	7	11	4	4	2	0	5	0	0	0.528	0.914	1.000
198	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), CSF1R(3), EGF(3), EGFR(3), PDGFRA(4), PRKCA(2), SH3KBP1(1)	963036	17	8	17	9	13	1	1	0	2	0	0.573	0.915	1.000
199	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(2), BAX(1), BCL2(1), CSF2RB(1), IGF1(1), IGF1R(4), KIT(4), PRKACG(2), PRKAR1B(1)	1073268	17	8	17	9	10	1	2	3	1	0	0.590	0.915	1.000
200	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), GRIN1(1), JAK2(1), NFKB1(1)	616686	4	2	4	1	2	0	0	1	1	0	0.476	0.915	1.000
201	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	CCNE1(1), E2F1(1), NFKB1(1), RAF1(1), RB1(1)	969341	5	4	5	0	3	0	0	1	1	0	0.126	0.917	1.000
202	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	MAPK8(1), NFKB1(1), TNFRSF13B(1), TNFRSF17(2), TRAF2(1), TRAF6(1)	706258	7	5	7	3	6	0	0	1	0	0	0.512	0.917	1.000
203	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(1), JAK2(1), JAK3(1), PTPRU(2)	672601	5	3	5	2	3	1	0	1	0	0	0.509	0.921	1.000
204	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGAP5(1), CASP8(1), PRF1(3)	640035	6	4	6	4	2	1	1	1	1	0	0.869	0.923	1.000
205	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GALNS(1), GLB1(2), HEXA(1), IDUA(1), LCT(3), NAGLU(1)	706868	9	3	9	4	5	1	0	1	2	0	0.484	0.925	1.000
206	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), CHAT(1), DBH(1), DDC(2), GAD2(1), HDC(2), SLC18A3(1), TPH1(1)	693860	10	4	10	4	7	0	1	0	2	0	0.254	0.929	1.000
207	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	BDKRB2(3), CHRM1(1), FLT1(4), FLT4(2), KDR(7), NOS3(3), PDE2A(4), PDE3A(1), PRKACG(2), PRKAR1B(1), PRKG1(1), PRKG2(3), RYR2(8), SLC7A1(1), SYT1(2)	1985593	43	13	42	18	27	3	3	9	1	0	0.175	0.930	1.000
208	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(1), CRK(1), CXCR4(1), GNAQ(1), MAP2K1(1), NFKB1(1), PIK3C2G(4), PRKCA(2), PTK2(2), PTK2B(2), PXN(1), RAF1(1)	1346767	18	10	18	7	11	1	0	5	1	0	0.414	0.931	1.000
209	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	DFFA(1), DFFB(1), TOP2A(1)	440214	3	1	3	2	1	0	1	1	0	0	0.857	0.935	1.000
210	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(2), AXIN1(2), BTRC(1), CREBBP(3), CSNK1D(1), CTNNB1(1), FZD1(1), TLE1(1), WIF1(1)	1430650	13	8	13	9	6	1	1	2	3	0	0.924	0.937	1.000
211	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	MEF2B(1), NTRK1(4)	930482	5	5	5	3	1	1	1	1	1	0	0.818	0.940	1.000
212	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(4), C6(1), C7(5), C8A(3)	603138	13	7	13	5	10	0	1	2	0	0	0.389	0.940	1.000
213	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(4), CR2(3), HLA-DRA(2), ITGAL(2), PTPRC(2)	730654	13	6	13	5	9	2	0	1	1	0	0.356	0.941	1.000
214	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(3), EPHB1(6), FYN(1), L1CAM(2), SELP(1)	777121	13	8	13	7	11	0	0	1	1	0	0.604	0.941	1.000
215	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH9A1(1), EHHADH(2), HADHA(2), SDS(1)	598729	6	5	6	5	4	1	0	0	1	0	0.738	0.941	1.000
216	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	HEMK1(1), METTL2B(2), METTL6(1), PRMT5(1), PRMT8(2)	693653	7	4	7	2	6	1	0	0	0	0	0.257	0.943	1.000
217	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	BCAR1(1), PTEN(1), PTK2(2), SOS1(1)	936660	5	4	5	2	2	1	0	2	0	0	0.725	0.944	1.000
218	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(1), ALDOC(1), G6PD(1), GPI(2), PGD(1), PRPS1L1(2), PRPS2(1), RBKS(1), TKTL2(3)	1195523	13	6	13	7	10	1	1	0	1	0	0.384	0.944	1.000
219	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP6(5), ACPP(1), ENPP1(1), ENPP3(1)	732707	8	3	8	2	6	0	1	0	1	0	0.261	0.944	1.000
220	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(1), TAT(1)	430886	2	1	2	2	1	1	0	0	0	0	0.829	0.945	1.000
221	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CAPN2(2), CAPNS1(1), EP300(2), NFATC1(1), NFATC2(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(2), SYT1(2)	1215772	16	7	16	8	13	0	0	0	3	0	0.446	0.948	1.000
222	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	MAP2K1(1), MAPK8(1), RAF1(1), SOS1(1)	936010	4	3	4	2	0	0	0	4	0	0	0.867	0.948	1.000
223	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	TPK1(1)	313212	1	1	1	0	1	0	0	0	0	0	0.665	0.949	1.000
224	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(3), EGFR(3), MAP2K1(1), RXRA(1)	840401	8	6	8	5	5	1	0	1	1	0	0.749	0.951	1.000
225	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	DUSP10(1), GAB1(1), GCK(5), IL1R1(2), MAP2K5(1), MAP2K7(1), MAP3K13(3), MAP3K2(2), MAP3K4(3), MAP3K5(1), MAP3K9(3), MAPK8(1), MAPK9(3), PAPPA(4), TP53(2), TRAF6(1)	2462122	34	13	34	12	24	2	1	4	3	0	0.272	0.951	1.000
226	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR2(1)	310841	1	1	1	0	1	0	0	0	0	0	0.651	0.953	1.000
227	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(2), TAT(1)	231486	3	1	3	1	3	0	0	0	0	0	0.483	0.953	1.000
228	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(4), ADH1A(2), ADH1B(4), ADH1C(3), ADH5(1), ADH6(2), ADH7(1), ALDH3B2(1), AOC2(1), AOX1(3), DBH(1), DDC(2), FAH(1), HEMK1(1), HGD(2), HPD(1), METTL2B(2), METTL6(1), MYST3(4), MYST4(5), PNPLA3(1), PRMT5(1), PRMT8(2), TAT(1), TPO(3)	2916663	50	12	48	20	35	3	3	6	3	0	0.104	0.955	1.000
229	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(2), CD2(1), CD3D(1), IL12A(1), IL12RB1(2), IL12RB2(1), JAK2(1), STAT4(2)	719059	11	4	11	6	6	1	0	2	2	0	0.589	0.956	1.000
230	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	JAK1(1), JAK2(1), PLA2G2A(1), PTPRU(2)	563017	5	2	5	1	4	0	0	1	0	0	0.308	0.957	1.000
231	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA5(1), PSMA6(1)	439045	3	2	3	1	3	0	0	0	0	0	0.535	0.960	1.000
232	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP6(5), ACPP(1), ALPI(1), ALPP(1), ALPPL2(2), CYP3A4(3), CYP3A5(1), DHRS3(1), DHRSX(1)	881164	16	7	16	8	10	2	1	1	2	0	0.373	0.961	1.000
233	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	DIAPH2(2), MCM2(1), MCM4(2), MCM5(1), ORC6L(1), POLA2(2), POLE(2), PRIM1(1), RFC1(1), RFC2(1), RPA2(1), UBC(1)	2500596	16	8	16	9	9	1	1	1	4	0	0.747	0.962	1.000
234	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(1), APOC1(1), CYP7A1(1), HMGCR(3), LDLR(3), LRP1(1)	1372641	10	6	9	9	7	0	0	1	2	0	0.859	0.966	1.000
235	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3D(1), IL2RA(1), TGFBR3(1)	515397	3	3	3	3	2	0	0	0	1	0	0.882	0.968	1.000
236	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	GNAS(3), NFKB1(1), NOS3(3), SYT1(2)	867153	9	5	9	4	8	0	0	0	1	0	0.463	0.968	1.000
237	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	BCL2(1), CBL(1), CFLAR(1), CRKL(1), E2F1(1), IL2RA(1), IL2RB(2), IL2RG(1), IRS1(1), JAK1(1), JAK3(1), RAF1(1), RPS6KB1(1), SOS1(1), STAT5B(1), SYK(1)	1768589	17	6	17	6	7	2	3	3	2	0	0.369	0.969	1.000
238	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	IL2RA(1), IL2RB(2), IL2RG(1), JAK1(1), JAK3(1), LCK(1), MAP2K1(1), MAPK8(1), RAF1(1), SOS1(1), STAT5B(1), SYK(1)	1132123	13	5	13	4	6	1	1	4	1	0	0.300	0.969	1.000
239	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(1), ASPH(1), EDN1(2), EP300(2), LDHA(1), NOS3(3), P4HB(1)	842105	11	4	11	1	9	1	0	0	1	0	0.0441	0.969	1.000
240	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	BCL2(1), BCR(2), CRKL(1), JAK2(1), MAP2K1(1), MAPK8(1), RAF1(1), SOS1(1), STAT5B(1)	1365483	10	6	10	4	2	2	0	5	1	0	0.694	0.970	1.000
241	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(1), JAK2(1), MAP2K1(1), RAF1(1), SOS1(1), STAT5B(1)	862377	6	5	6	3	2	0	0	4	0	0	0.787	0.973	1.000
242	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT2(2), PIK3CD(1), PTEN(1), PTK2B(2), SOS1(1)	1009724	7	5	7	3	3	0	0	2	2	0	0.772	0.974	1.000
243	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), HAO2(1), HYI(1), MDH1(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1)	631924	9	5	9	5	5	2	0	2	0	0	0.664	0.976	1.000
244	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ADH1A(2), ADH1B(4), ADH1C(3), ADH5(1), ADH6(2), ADH7(1), DHRS3(1), DHRSX(1), MYST3(4), MYST4(5), PNPLA3(1)	1238860	26	10	24	10	15	1	2	6	2	0	0.346	0.980	1.000
245	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K7(1), MAPK13(1), MAPK8(1), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(2), MAPK9(3), NFKB1(1), NFKBIL1(1), PIK3CD(1), SYT1(2), TRAF2(1), TRAF6(1)	1640899	20	9	20	8	12	0	0	5	3	0	0.363	0.981	1.000
246	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), HAO2(1), HYI(1), MDH1(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1)	661933	9	5	9	5	5	2	0	2	0	0	0.657	0.981	1.000
247	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(1), JAK3(1), STAT3(3)	574868	6	3	6	4	2	1	1	1	1	0	0.719	0.981	1.000
248	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(1), JAK1(1), JAK2(1), JAK3(1), STAT3(3), STAT5B(1)	897630	8	4	8	4	3	1	1	1	2	0	0.570	0.982	1.000
249	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(1)	282171	1	1	1	0	1	0	0	0	0	0	0.557	0.982	1.000
250	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACPP(1), ENPP1(1), ENPP3(1)	472408	3	2	3	2	3	0	0	0	0	0	0.744	0.984	1.000
251	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT6(5), ST3GAL1(1), WBSCR17(1)	712719	7	3	7	4	7	0	0	0	0	0	0.570	0.984	1.000
252	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GALNS(1), GLB1(2), HEXA(1), HPSE(1), HPSE2(1), IDUA(1), LCT(3), NAGLU(1), SPAM1(2)	1000319	13	4	13	5	8	1	0	1	3	0	0.307	0.986	1.000
253	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	NEK1(1)	341180	1	1	1	0	1	0	0	0	0	0	0.690	0.986	1.000
254	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(2), LARS(2)	498497	5	4	5	3	4	0	0	1	0	0	0.769	0.986	1.000
255	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(1), CHIT1(1), CTBS(1), GFPT1(1), GFPT2(1), HEXA(1), HK2(1), HK3(3)	1414391	11	7	11	3	6	1	1	2	1	0	0.236	0.986	1.000
256	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(2), NFATC1(1), NFATC2(3), PRKACG(2), PRKAR1B(1)	593914	9	4	9	8	8	0	0	0	1	0	0.777	0.987	1.000
257	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	BRCA1(1), BRCA2(2), CHEK2(1), FANCA(1), FANCD2(2), RAD1(1), TP53(2)	2174056	10	6	10	3	3	2	2	1	2	0	0.446	0.987	1.000
258	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(1), APAF1(1), BCL2(1), BIRC3(1), CASP8(1), CFLAR(1), DAXX(2), DFFA(1), DFFB(1), LMNA(3), LMNB2(1), MAP2K7(1), MAP3K5(1), MAPK8(1), NFKB1(1), NUMA1(1), PAK2(1), PTK2(2), RB1(1), SPTAN1(2), TRAF1(1), TRAF2(1)	3400454	27	9	27	9	14	1	2	6	4	0	0.205	0.987	1.000
259	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(3), EP300(2), ESR1(1), PELP1(1)	725687	7	4	7	3	6	0	1	0	0	0	0.510	0.987	1.000
260	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(4), MDH1(1), ME1(1), PC(2)	461229	8	4	8	5	4	2	0	2	0	0	0.659	0.987	1.000
261	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(1), EIF2B1(2), EIF2B3(2), FLT1(4), FLT4(2), KDR(7), NOS3(3), PRKCA(2), PTK2(2), PXN(1)	1685571	26	9	25	8	18	2	0	3	3	0	0.0920	0.989	1.000
262	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	MAP3K5(1), MAPK8(1), NFKB1(1), TNFSF9(1), TRAF2(1)	929655	5	4	5	2	4	0	0	1	0	0	0.570	0.989	1.000
263	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ACE2(3), AGTR1(2), AGTR2(1), ANPEP(2), CMA1(2), CPA3(2), ENPEP(3), MME(1), NLN(1), REN(2)	1031242	21	9	21	10	13	0	2	3	3	0	0.371	0.989	1.000
264	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1B(1), GLI2(5), GLI3(3), PRKACG(2), PRKAR1B(1), SMO(3)	814528	15	5	15	9	10	2	1	1	1	0	0.616	0.989	1.000
265	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2E2(1), GTF2H1(1), GTF2H4(1), GTF2I(1), GTF2IRD1(1), TAF1(1), TAF13(1), TAF1L(5), TAF4(2), TAF7(1), TAF7L(2)	1794914	17	6	17	4	10	4	1	1	1	0	0.121	0.990	1.000
266	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(2), GNAS(3)	319689	5	2	5	3	5	0	0	0	0	0	0.605	0.990	1.000
267	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP5(1), BMP6(1), BTRC(1), CSNK1A1L(2), CSNK1D(1), FBXW11(1), GLI1(2), GLI2(5), GLI3(3), HHIP(1), LRP2(7), PRKACG(2), PRKX(1), PTCH1(1), PTCH2(3), RAB23(1), SMO(3), STK36(1), WNT10A(1), WNT10B(1), WNT16(1), WNT2(2), WNT3(1), WNT3A(1), WNT5A(1), WNT5B(1), WNT7A(3), WNT7B(2), WNT8A(1), ZIC2(1)	2954111	53	10	53	21	38	5	3	4	3	0	0.0790	0.991	1.000
268	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(1), FYN(1), MAP2K1(1), MYLK(2), PTK2(2), PXN(1), RAF1(1), TLN1(1)	1842549	10	6	10	4	4	0	0	4	2	0	0.622	0.991	1.000
269	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH4A1(1), ALDH5A1(2), CAD(2), GAD2(1), GFPT1(1), GLS2(2), GPT(1), GSS(1), NADSYN1(2), QARS(2)	1640379	15	6	15	7	11	1	2	1	0	0	0.400	0.991	1.000
270	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	GNAQ(1), NFATC1(1), NFATC2(3), NFATC4(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(2), SP1(2), SYT1(2)	1025510	15	9	15	8	10	0	1	2	2	0	0.624	0.991	1.000
271	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(1), POLR2A(2)	663293	3	2	3	2	3	0	0	0	0	0	0.686	0.992	1.000
272	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), BCAT2(1), IARS(2), IARS2(2), LARS(2), VARS(4), VARS2(1)	936866	13	8	13	7	8	2	0	2	1	0	0.646	0.992	1.000
273	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	CHST1(1), CHST4(1), FUT8(1), ST3GAL1(1)	616445	4	2	4	1	4	0	0	0	0	0	0.282	0.993	1.000
274	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	MUSK(1), PTK2(2), PTK2B(2), TERT(2)	804412	7	5	7	3	6	0	0	1	0	0	0.411	0.993	1.000
275	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(3), GNAS(3), IGF1R(4), MAP2K1(1), MKNK2(1), PDGFRA(4), PTPRR(2), RAF1(1), SOS1(1), STAT3(3)	1618738	23	8	23	4	17	0	1	4	1	0	0.0222	0.994	1.000
276	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(2), CDH1(1), CREBBP(3), EP300(2), MAP2K1(1)	1263237	9	6	9	7	6	0	1	1	1	0	0.916	0.994	1.000
277	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(1), PIGB(1), PIGU(2)	1180674	4	4	4	3	2	0	0	1	1	0	0.860	0.995	1.000
278	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	FUT8(1), ST3GAL1(1)	389551	2	1	2	1	2	0	0	0	0	0	0.647	0.995	1.000
279	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACPP(1), ALPI(1), ALPP(1), ALPPL2(2), CYP19A1(3), CYP1A1(3), CYP1A2(1), CYP2A13(2), CYP2A6(2), CYP2A7(1), CYP2B6(3), CYP2C18(2), CYP2C19(2), CYP2C8(2), CYP2C9(3), CYP2E1(2), CYP2F1(1), CYP3A4(3), CYP3A5(1), CYP4B1(1), CYP4F8(1)	1422797	38	10	38	14	30	2	0	1	5	0	0.0215	0.996	1.000
280	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(2), ALDH7A1(2), ALDH9A1(1), CYP2C19(2), CYP2C9(3), DHRS3(1), DHRSX(1), EHHADH(2), HADHA(2), MYST3(4), MYST4(5), PNPLA3(1)	1535653	26	9	26	10	18	2	1	3	2	0	0.222	0.997	1.000
281	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	FUT1(2), FUT2(1), FUT3(1), FUT9(2)	787845	6	4	6	4	4	1	0	1	0	0	0.667	0.997	1.000
282	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA5(1), PSMA6(1)	801617	3	2	3	0	3	0	0	0	0	0	0.239	0.997	1.000
283	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ABP1(4), ALDH9A1(1), AOC2(1), AOX1(3), ASMT(1), CAT(1), CYP19A1(3), CYP1A1(3), CYP1A2(1), CYP2A13(2), CYP2A6(2), CYP2A7(1), CYP2B6(3), CYP2C18(2), CYP2C19(2), CYP2C8(2), CYP2C9(3), CYP2E1(2), CYP2F1(1), CYP3A4(3), CYP3A5(1), CYP4B1(1), CYP4F8(1), DDC(2), EHHADH(2), HADHA(2), KYNU(1), SDS(1), TDO2(1), TPH1(1)	2688671	54	13	54	22	45	1	0	2	6	0	0.0330	0.998	1.000
284	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GCK(5), GFPT1(1), HEXA(1), HK2(1), HK3(3)	841804	11	3	11	4	9	0	1	1	0	0	0.333	0.998	1.000
285	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	DGKA(1), ITPR1(1), ITPR2(1), ITPR3(1), MAP2K1(1), NR1I3(1), PDE3A(1), PI3(2), PIK3C2G(4), PIK3CD(1), RIPK3(2)	2375117	16	7	16	5	8	2	0	4	2	0	0.243	0.998	1.000
286	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(2), PRKACG(2)	498433	4	2	4	2	4	0	0	0	0	0	0.593	0.998	1.000
287	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	CA1(1), CA12(1), CA2(3), CA9(1), GLS2(2)	927548	8	5	8	5	6	0	1	0	1	0	0.644	0.999	1.000
288	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(1), ALDOC(1), GPT(1), MDH1(1), ME1(1), PKLR(3), PKM2(1)	893423	9	6	9	7	7	1	0	0	1	0	0.674	0.999	1.000
289	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F11(1), F12(1), F13B(1), F2(1), F7(1), F8(2), F9(1), FGA(3), FGB(1), LPA(3), PLG(1), SERPINB2(3), SERPINE1(1), SERPINF2(2), VWF(6)	1722600	28	6	28	10	18	2	2	2	4	0	0.214	0.999	1.000
290	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	UBE2J2(2), UBE3A(1)	523670	3	2	3	2	3	0	0	0	0	0	0.757	0.999	1.000
291	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	HDAC5(1), IGF1(1), IGF1R(4), INSR(7), MAP2K6(1), MEF2B(1), NFATC1(1), NFATC2(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), SYT1(2)	1720199	24	10	24	10	15	4	0	3	2	0	0.218	0.999	1.000
292	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(3), EP300(2), NCOA1(1), PPARG(2), RXRA(1)	921235	9	5	9	4	7	1	1	0	0	0	0.556	0.999	1.000
293	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(5), HK2(1), HK3(3)	506948	9	3	9	4	9	0	0	0	0	0	0.365	0.999	1.000
294	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(1), F2R(1), MAP2K1(1), PLA2G4A(3), PLCB1(3), PRKCA(2), PTK2(2), RAF1(1), SYK(1)	1195049	15	8	15	9	8	1	1	4	1	0	0.818	0.999	1.000
295	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC3(1), CASP8(1), CFLAR(1), NFKB1(1), NFKBIL1(1), TRAF2(1)	1334347	6	4	6	5	4	0	0	1	1	0	0.921	0.999	1.000
296	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	BRCA1(1), CHEK2(1), MAPK8(1), NFKB1(1), TP53(2)	1456518	6	6	6	5	2	1	1	1	1	0	0.946	0.999	1.000
297	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK2A(1), CAMK4(1), HDAC5(1), MEF2B(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), SLC2A4(1), SYT1(2)	985509	10	5	10	6	6	1	1	1	1	0	0.602	0.999	1.000
298	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	APC(2), AR(1), CCL15(2), CCL16(1), EGFR(3), GNA11(3), GNAQ(1), ITPR1(1), ITPR2(1), ITPR3(1), KCNJ5(1), PIK3CD(1), RAF1(1)	2597219	19	11	18	9	11	0	0	5	3	0	0.587	0.999	1.000
299	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	27	BCAR1(1), CRKL(1), GNAQ(1), MAP2K1(1), MAPK8(1), PRKCA(2), PTK2B(2), RAF1(1), SOS1(1), SYT1(2)	1373431	13	8	13	9	6	1	0	5	1	0	0.909	0.999	1.000
300	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASRGL1(1), CA1(1), CA12(1), CA13(1), CA2(3), CA9(1), GLS2(2)	1038667	10	5	10	6	8	0	1	0	1	0	0.605	0.999	1.000
301	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ALDH5A1(2), ALDH9A1(1), EHHADH(2), GAD2(1), HADHA(2), OXCT1(1), SDS(1)	1282638	11	6	11	8	7	2	1	0	1	0	0.719	1.000	1.000
302	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	JAK2(1), MAP2K1(1), PRKCA(2), RAF1(1), SOS1(1), STAT3(3), STAT5B(1), THPO(1)	1466168	11	6	11	4	5	0	1	4	1	0	0.501	1.000	1.000
303	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(5), HK2(1), HK3(3)	576963	9	3	9	4	9	0	0	0	0	0	0.351	1.000	1.000
304	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	CREB5(2), DUSP10(1), IL1R1(2), MAP2K6(1), MAP3K4(3), MAP3K5(1), MAPK13(1), MKNK2(1), NFKB1(1), TRAF6(1)	1633528	14	8	14	9	11	1	0	1	1	0	0.741	1.000	1.000
305	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GHR(1), INSR(7), IRS1(1), JAK2(1), MAP2K1(1), PRKCA(2), RAF1(1), SLC2A4(1), SOS1(1), STAT5B(1)	1630487	17	9	17	9	8	3	0	6	0	0	0.655	1.000	1.000
306	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(1), COX15(1), CP(1), HMBS(1), PPOX(1), UGT1A10(3), UGT1A3(1), UGT1A4(3), UGT1A5(1), UGT2B10(1), UGT2B11(1), UGT2B15(4), UGT2B28(2), UGT2B4(2), UGT2B7(1), UROS(1)	2060078	25	9	25	11	15	1	5	1	3	0	0.303	1.000	1.000
307	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(3), SCAP(1), SREBF2(1)	588926	5	3	5	3	3	1	1	0	0	0	0.622	1.000	1.000
308	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(1), HLA-DRA(2), IL12A(1), IL12RB1(2), IL12RB2(1), IL18R1(1), IL2RA(1)	624707	9	4	9	4	8	0	0	1	0	0	0.455	1.000	1.000
309	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	CAD(2), CANT1(1), CTPS2(2), DPYD(4), ENTPD1(2), ENTPD3(1), ENTPD5(1), ENTPD6(1), NT5C1B(4), NT5E(1), POLA2(2), POLE(2), POLR1A(2), POLR1B(1), POLR2A(2), POLR3A(2), POLR3K(1), PRIM1(1), PRIM2(3), TXNRD2(1), UPP2(1)	3999073	37	12	37	16	27	1	1	5	3	0	0.331	1.000	1.000
310	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(2), POLR1B(1), POLR2A(2), POLR3A(2), POLR3K(1)	1162988	8	4	8	3	5	1	0	2	0	0	0.445	1.000	1.000
311	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ALDH9A1(1), AOX1(3), BCAT1(1), BCKDHB(1), EHHADH(2), HADHA(2), HIBADH(1), IVD(1), OXCT1(1), PCCB(1), SDS(1)	1780842	16	9	16	9	10	1	0	3	2	0	0.660	1.000	1.000
312	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(4), ALDH3B2(1), AOC2(1), DDC(2), HPD(1), LPO(3), MPO(3), MYST3(4), MYST4(5), PNPLA3(1), TAT(1), TPO(3)	1692936	29	8	29	13	21	1	1	3	3	0	0.242	1.000	1.000
313	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	38	DAXX(2), HMGN1(1), MAP2K6(1), MAP3K5(1), MAP3K9(3), MEF2B(1), PLA2G4A(3), TRAF2(1)	1756977	13	5	13	6	7	4	0	1	1	0	0.682	1.000	1.000
314	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	AKT2(2), GNAQ(1), ITPR1(1), ITPR2(1), ITPR3(1), NFKB1(1), NFKBIL1(1), PIK3CB(2), PLD2(1), PLD3(1)	2201880	12	6	12	9	6	0	0	3	3	0	0.861	1.000	1.000
315	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	CREB5(2), CREBBP(3), CRKL(1), EGR1(2), EGR4(1), GNAQ(1), MAP1B(3), MAP2K7(1), MAPK8(1), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(2), MAPK9(3), NTRK1(4), OPN1LW(1), PIK3C2G(4), PIK3CD(1), PTPN11(1)	2514027	36	12	36	15	17	2	3	7	7	0	0.486	1.000	1.000
316	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	BRCA1(1), CHEK2(1), EP300(2), MYT1(2), TP53(2)	2071196	8	6	8	6	5	1	1	0	1	0	0.890	1.000	1.000
317	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ALDH9A1(1), EHHADH(2), HADHA(2), LDHA(1), MLYCD(1), PCCB(1), SDS(1), SUCLG2(1)	1639933	10	8	10	9	8	1	0	0	1	0	0.882	1.000	1.000
318	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(1), ALDOC(1), G6PD(1), GPI(2), PGD(1), PRPS1L1(2), PRPS2(1), RBKS(1)	1010276	10	6	10	8	7	1	1	0	1	0	0.717	1.000	1.000
319	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	JAK2(1), MAP2K1(1), MAPK8(1), RAF1(1), SOS1(1), STAT5B(1)	1049581	6	4	6	4	1	0	0	5	0	0	0.910	1.000	1.000
320	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	IKBKAP(1), NFKB1(1), TRAF1(1), TRAF2(1)	1092341	4	3	4	6	2	0	0	1	1	0	0.977	1.000	1.000
321	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	MAP2K6(1), MAP4K2(1), MAPK8(1), NFKB1(1), TRAF2(1)	1163348	5	4	5	6	3	0	0	1	1	0	0.942	1.000	1.000
322	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	GTF2E2(1), GTF2H1(1), GTF2H4(1), POLR1A(2), POLR1B(1), POLR2A(2), POLR3K(1), TAF13(1), TAF7(1)	1740273	11	5	11	6	6	2	1	1	1	0	0.615	1.000	1.000
323	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	RPL14(1), RPL27A(1), RPL7(1), RPS2(1), RPS29(1), RPS3A(1), RPSA(1)	1115863	7	4	7	5	4	0	1	1	1	0	0.755	1.000	1.000
324	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AP2A1(1), AP2M1(1), BTK(3), EEA1(1), PRKCZ(1), RPS6KB1(1)	1192504	8	6	8	6	5	1	1	0	1	0	0.685	1.000	1.000
325	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT2(2), BCL2(1), IRS1(1), JAK1(1), JAK3(1), PIK3CD(1), RAF1(1), SOS1(1), SOS2(2), STAT6(1)	1793011	12	6	12	6	5	2	0	3	2	0	0.728	1.000	1.000
326	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(4), ALDH3B2(1), AOC2(1), DDC(2), HPD(1), LPO(3), MPO(3), PRDX1(2), TAT(1), TPO(3)	1080155	21	8	21	11	18	0	0	1	2	0	0.264	1.000	1.000
327	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	MYLK(2), NCF2(1), PDGFRA(4), RPS6KB1(1), VAV1(3)	1698883	11	7	11	9	9	0	1	0	1	0	0.875	1.000	1.000
328	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	CD74(1), CD8B(1), CIITA(1), HLA-B(1), HLA-DPB1(1), HLA-DQA1(2), HLA-DQB1(1), HLA-DRA(2), HSP90AA1(1), HSP90AB1(1), IFNA14(1), IFNA16(1), IFNA6(1), IFNA7(1), KIR2DL1(4), KIR2DL3(2), KIR2DL4(1), KIR2DS4(4), KIR3DL1(4), KLRC2(1), KLRD1(1), PDIA3(1), PSME2(1), TAP2(1)	2275377	36	8	36	15	26	4	2	3	1	0	0.115	1.000	1.000
329	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(1), G6PC2(1), GAA(1), GCK(5), GLA(1), GLB1(2), HK2(1), HK3(3), LCT(3), MGAM(12)	1886568	30	8	30	14	24	3	0	3	0	0	0.206	1.000	1.000
330	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(1), BAI1(1), BAX(1), CASP8(1), CCNB3(3), CCND3(1), CCNE1(1), CCNE2(3), CDKN2A(2), CHEK2(1), EI24(1), FAS(1), GTSE1(2), IGF1(1), PERP(1), PTEN(1), SERPINB5(2), SERPINE1(1), STEAP3(1), THBS1(1), TNFRSF10B(1), TP53(2), TSC2(1)	3185108	31	16	30	11	10	4	3	7	7	0	0.336	1.000	1.000
331	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(3), E2F1(1), ETS2(1), HDAC5(1), SIN3A(1)	1286104	7	5	7	6	3	1	0	2	1	0	0.891	1.000	1.000
332	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(4), ALDH3B2(1), ALDH7A1(2), ALDH9A1(1), AOC2(1), CNDP1(2), DDC(2), HARS(1), HARS2(1), HDC(2), HEMK1(1), HNMT(1), METTL2B(2), METTL6(1), PRMT5(1), PRMT8(2), PRPS2(1), UROC1(2)	1949559	28	7	28	12	22	2	0	2	2	0	0.120	1.000	1.000
333	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	JAK1(1), MAP2K1(1), MAPK8(1), PDGFRA(4), PRKCA(2), RAF1(1), SOS1(1), STAT3(3)	1705797	14	7	14	6	8	0	1	4	1	0	0.509	1.000	1.000
334	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(4), ACO1(1), IDH1(3), MDH1(1), OGDH(2), OGDHL(4), PC(2), PCK1(3), SUCLG2(1)	1486234	21	10	20	10	17	1	0	3	0	0	0.326	1.000	1.000
335	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(1), CREBBP(3), EP300(2), ESR1(1), GRIP1(2), HDAC3(1), HDAC4(2), HDAC5(1), NRIP1(1), PELP1(1), POLR2A(2)	2242208	17	7	17	9	13	0	1	3	0	0	0.590	1.000	1.000
336	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(4), ADH1A(2), ADH1B(4), ADH1C(3), ADH6(2), ADH7(1), ALDH3B2(1), AOC2(1), AOX1(3), DBH(1), DDC(2), FAH(1), HGD(2), HPD(1), TAT(1), TPO(3)	1547722	32	10	30	16	25	1	2	3	1	0	0.245	1.000	1.000
337	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(2), ITGAV(2), PDGFRA(4), PLCB1(3), PRKCA(2), PTK2(2)	1335449	15	7	15	7	13	0	0	2	0	0	0.453	1.000	1.000
338	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	ADSL(2), AGXT2(2), CAD(2), CRAT(1), GAD2(1), GPT(1), NARS(1), PC(2)	1295340	12	4	12	7	9	1	1	1	0	0	0.523	1.000	1.000
339	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(2), ANAPC5(2), ANAPC7(1), BTRC(1), CDC27(1), CUL3(1), FBXW11(1), FBXW7(1), FZR1(1), ITCH(2), SKP2(1), WWP2(1)	1962809	15	10	15	9	9	0	0	4	2	0	0.873	1.000	1.000
340	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	FPR1(4), MAP2K1(1), MAP2K6(1), NCF2(1), NFATC1(1), NFATC2(3), NFATC4(1), NFKB1(1), PIK3C2G(4), PLCB1(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), RAF1(1), SYT1(2)	1845151	26	10	26	11	19	0	0	3	4	0	0.309	1.000	1.000
341	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(4), ADH1C(3), ADH5(1), ADH6(2), ADH7(1), AGPAT1(2), AGPAT4(1), AKR1A1(1), AKR1B1(1), ALDH7A1(2), ALDH9A1(1), CEL(1), DGAT2(3), DGKA(1), DGKB(3), DGKD(2), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), GK(1), GK2(2), GLA(1), GLB1(2), LCT(3), LIPA(3), LIPF(4), LIPG(1), PNLIPRP1(2), PNLIPRP2(1), PNPLA3(1), PPAP2C(1)	2897133	60	16	58	28	41	5	3	8	3	0	0.222	1.000	1.000
342	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ABP1(4), ALDH7A1(2), ALDH9A1(1), AOC2(1), AOX1(3), ASMT(1), CAT(1), CYP1A1(3), CYP1A2(1), DDC(2), EHHADH(2), HADHA(2), HEMK1(1), HSD17B4(1), INMT(1), KYNU(1), LNX1(1), METTL2B(2), METTL6(1), OGDH(2), OGDHL(4), PRMT5(1), PRMT8(2), TDO2(1), TPH1(1)	2981115	42	10	42	19	39	2	0	1	0	0	0.120	1.000	1.000
343	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGTR1(2), EGFR(3), GNAQ(1), MAP2K1(1), MAPK8(1), MEF2B(1), PRKCA(2), PTK2(2), PTK2B(2), RAF1(1), SOS1(1), SYT1(2)	1617222	19	8	19	9	12	1	0	6	0	0	0.599	1.000	1.000
344	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	83	DAXX(2), MAP2K1(1), MAP2K5(1), MAP2K6(1), MAP2K7(1), MAP3K13(3), MAP3K2(2), MAP3K4(3), MAP3K5(1), MAP3K6(2), MAP3K9(3), MAP4K2(1), MAP4K3(1), MAPK13(1), MAPK8(1), MAPK9(3), MAPKAPK3(1), MEF2B(1), MKNK2(1), NFKB1(1), PAK2(1), RAF1(1), RPS6KA2(1), RPS6KA4(2), RPS6KB1(1), SP1(2), TRAF2(1)	4598981	40	14	40	17	24	4	2	7	3	0	0.350	1.000	1.000
345	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	68	AKT2(2), KDR(7), KRAS(3), MAP2K1(1), MAPK13(1), MAPKAPK3(1), NFATC1(1), NFATC2(3), NFATC4(1), NOS3(3), PIK3CB(2), PIK3CD(1), PIK3R2(1), PLA2G2A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCG2(2), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRKCA(2), PRKCG(1), PTGS2(2), PTK2(2), PXN(1), RAF1(1)	3527959	49	13	49	22	30	2	2	6	9	0	0.346	1.000	1.000
346	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(1), ABCA10(1), ABCA12(7), ABCA13(11), ABCA2(1), ABCA3(4), ABCA4(4), ABCA5(2), ABCA6(3), ABCA7(1), ABCA8(2), ABCA9(2), ABCB1(4), ABCB11(9), ABCB4(2), ABCB5(7), ABCC10(1), ABCC11(4), ABCC12(3), ABCC2(1), ABCC3(3), ABCC4(1), ABCC6(2), ABCC8(7), ABCC9(7), ABCD2(3), ABCG2(1), ABCG4(1), ABCG5(5), ABCG8(4), CFTR(4), TAP2(1)	5736751	109	13	109	44	78	9	3	10	9	0	0.00402	1.000	1.000
347	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACTG1(1), ACTN1(2), ACTN2(5), ACTN3(2), ACVR1C(2), CDH1(1), CREBBP(3), CTNNA2(4), CTNNA3(4), CTNNB1(1), CTNND1(1), EGFR(3), EP300(2), FYN(1), IGF1R(4), INSR(7), IQGAP1(1), MLLT4(4), PARD3(2), PTPN1(1), PTPRB(10), PTPRF(2), SNAI2(1), SORBS1(1), SSX2IP(1), TCF7(1), TCF7L1(1), TCF7L2(2), WAS(1), YES1(1)	5886815	72	17	71	28	53	4	4	6	5	0	0.0935	1.000	1.000
348	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(1), ADORA1(1), ADORA3(2), ADRA1A(1), AGTR1(2), AGTR2(1), BDKRB2(3), BRS3(2), C5AR1(2), CALCR(2), CHRM1(1), CHRM2(1), CHRM3(2), CHRM4(1), CHRM5(1), CRHR1(1), DRD2(2), DRD5(3), F2(1), F2R(1), F2RL1(2), FPR1(4), FSHR(2), GABBR1(1), GABBR2(1), GABRA1(1), GABRA2(1), GABRA4(1), GABRA6(5), GABRB1(1), GABRB2(3), GABRD(1), GABRE(2), GABRG1(2), GABRG2(1), GABRQ(1), GABRR1(2), GH2(1), GHR(1), GHRHR(1), GLP1R(2), GLRA1(4), GLRA2(1), GLRB(2), GPR156(1), GPR50(1), GPR63(1), GRIA1(5), GRIA2(1), GRIA4(2), GRID1(2), GRID2(2), GRIK2(1), GRIK3(3), GRIK4(1), GRIN1(1), GRIN2A(7), GRIN2B(3), GRIN3A(4), GRIN3B(1), GRM1(2), GRM3(4), GRM4(1), GRM5(1), GRM6(2), GRM7(3), GRM8(7), GZMA(1), HCRTR2(1), HRH1(1), HTR1A(1), HTR1E(1), HTR2A(1), HTR5A(1), LEPR(3), LHCGR(2), MC3R(1), MC5R(1), MTNR1B(1), NMUR1(1), NMUR2(2), NPBWR2(2), NPY1R(4), NPY2R(3), NPY5R(4), NTSR1(1), NTSR2(1), OPRK1(3), OPRM1(2), P2RX3(1), P2RX5(2), P2RX7(1), P2RY1(2), P2RY10(1), PARD3(2), PPYR1(1), PRLR(1), PRSS1(3), PTGDR(3), PTGER2(1), PTGFR(4), PTGIR(1), PTH2R(1), SSTR3(1), TAAR2(1), TAAR6(1), TAAR8(1), TACR1(1), TACR2(2), TACR3(1), TBXA2R(1), TRHR(1), VIPR2(1)	10744583	203	25	201	145	135	19	9	23	17	0	0.389	1.000	1.000
349	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	246	ACVR1C(2), AKT2(2), ARRB2(1), ATF4(1), CACNA1A(3), CACNA1B(4), CACNA1C(5), CACNA1D(2), CACNA1E(9), CACNA1F(1), CACNA1G(3), CACNA1H(1), CACNA1I(4), CACNA1S(3), CACNA2D1(3), CACNA2D3(3), CACNA2D4(2), CACNB2(2), CACNG2(1), CACNG3(3), CACNG5(1), CACNG7(1), CD14(1), CRK(1), CRKL(1), DAXX(2), DUSP10(1), EGF(3), EGFR(3), FAS(1), FASLG(3), FGF11(1), FGF12(1), FGF14(1), FGF4(1), FGF5(1), FGFR2(5), FGFR3(1), FLNA(1), FLNB(7), FLNC(4), IL1R1(2), IL1R2(1), JUND(1), KRAS(3), MAP2K1(1), MAP2K5(1), MAP2K6(1), MAP2K7(1), MAP3K13(3), MAP3K2(2), MAP3K4(3), MAP3K5(1), MAP3K6(2), MAP4K2(1), MAP4K3(1), MAPK13(1), MAPK8(1), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(2), MAPK9(3), MAPKAPK3(1), MAPT(1), MKNK2(1), MOS(2), NFATC2(3), NFATC4(1), NFKB1(1), NTRK1(4), NTRK2(1), PAK2(1), PDGFRA(4), PLA2G2A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRKACG(2), PRKCA(2), PRKCG(1), PRKX(1), PTPRR(2), RAF1(1), RAPGEF2(2), RASA2(2), RASGRF2(1), RASGRP1(1), RASGRP3(2), RPS6KA2(1), RPS6KA4(2), RPS6KA6(2), SOS1(1), SOS2(2), TAOK1(1), TAOK2(3), TAOK3(1), TP53(2), TRAF2(1), TRAF6(1)	13812674	197	23	197	125	138	7	11	20	21	0	0.815	1.000	1.000
350	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	AMHR2(4), BMPR2(1), CCL14(1), CCL15(2), CCL16(1), CCL7(1), CCR1(2), CCR5(2), CCR8(1), CCR9(1), CSF1R(3), CSF2RA(1), CSF2RB(1), CX3CR1(1), CXCR4(1), CXCR6(1), EGF(3), EGFR(3), FAS(1), FASLG(3), FLT1(4), FLT3(2), FLT4(2), GDF5(2), GH2(1), GHR(1), HGF(3), IFNA14(1), IFNA16(1), IFNA6(1), IFNA7(1), IFNAR2(1), IL10RA(1), IL12A(1), IL12RB1(2), IL12RB2(1), IL17RB(1), IL18R1(1), IL18RAP(1), IL1R1(2), IL1R2(1), IL1RAP(1), IL20(1), IL20RA(1), IL21(1), IL21R(3), IL23R(1), IL25(1), IL26(1), IL28RA(1), IL2RA(1), IL2RB(2), IL2RG(1), IL5RA(1), IL6(1), IL6R(1), IL6ST(1), IL7R(3), IL9R(1), INHBA(1), INHBC(2), KDR(7), KIT(4), LEPR(3), LIFR(4), OSMR(7), PDGFC(2), PDGFRA(4), PLEKHO2(1), PRLR(1), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11B(1), TNFRSF13B(1), TNFRSF17(2), TNFRSF21(1), TNFRSF25(1), TNFRSF8(3), TNFSF10(1), TNFSF14(1), TNFSF15(1), TNFSF9(1), TPO(3), XCR1(1)	8693843	144	23	144	93	97	12	5	14	16	0	0.806	1.000	1.000
351	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	191	ACTG1(1), ACTN1(2), ACTN2(5), ACTN3(2), AKT2(2), ARHGAP5(1), BCAR1(1), BCL2(1), BIRC3(1), CAPN2(2), CCND3(1), COL11A1(6), COL11A2(6), COL1A1(6), COL1A2(4), COL2A1(6), COL3A1(6), COL4A2(2), COL4A4(10), COL4A6(2), COL5A1(6), COL5A3(8), COL6A1(2), COL6A2(1), COL6A3(7), COL6A6(5), CRK(1), CRKL(1), CTNNB1(1), EGF(3), EGFR(3), FLNA(1), FLNB(7), FLNC(4), FLT1(4), FN1(2), FYN(1), GRLF1(1), HGF(3), IGF1(1), IGF1R(4), ITGA10(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA6(1), ITGA7(3), ITGA8(4), ITGAV(2), ITGB4(4), ITGB5(2), ITGB6(3), ITGB8(1), KDR(7), LAMA1(3), LAMA2(4), LAMA3(1), LAMA4(1), LAMA5(4), LAMB2(2), LAMB3(2), LAMB4(1), LAMC2(1), MAP2K1(1), MAPK8(1), MAPK9(3), MYLK(2), MYLK2(3), PAK2(1), PAK3(1), PAK7(1), PDGFC(2), PDGFD(1), PDGFRA(4), PIK3CB(2), PIK3CD(1), PIK3R2(1), PIP5K1C(1), PRKCA(2), PRKCG(1), PTEN(1), PTK2(2), PXN(1), RAF1(1), RELN(11), ROCK2(1), SHC3(1), SOS1(1), SOS2(2), THBS1(1), THBS3(1), THBS4(2), TLN1(1), TNC(5), TNN(4), TNR(8), TNXB(17), VAV1(3), VWF(6), ZYX(1)	18201587	281	23	280	132	206	13	5	31	25	1	0.240	1.000	1.000
352	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(2), ADCY2(1), ADCY7(3), ADCY8(1), ADCY9(2), ADRA1A(1), ADRA1D(1), AGTR1(2), ATP2A1(2), ATP2A2(1), ATP2A3(3), ATP2B1(1), ATP2B2(3), ATP2B3(1), BDKRB2(3), CACNA1A(3), CACNA1B(4), CACNA1C(5), CACNA1D(2), CACNA1E(9), CACNA1F(1), CACNA1G(3), CACNA1H(1), CACNA1I(4), CACNA1S(3), CAMK2A(1), CAMK4(1), CD38(2), CHRM1(1), CHRM2(1), CHRM3(2), CHRM5(1), EGFR(3), ERBB4(6), F2R(1), GNA11(3), GNAQ(1), GNAS(3), GRIN1(1), GRIN2A(7), GRM1(2), GRM5(1), HRH1(1), HTR2A(1), HTR5A(1), ITPR1(1), ITPR2(1), ITPR3(1), LHCGR(2), MYLK(2), MYLK2(3), NOS1(3), NOS3(3), NTSR1(1), P2RX3(1), P2RX5(2), P2RX7(1), PDE1A(3), PDE1B(2), PDE1C(4), PDGFRA(4), PHKA1(3), PHKB(1), PLCB1(3), PLCB3(1), PLCB4(9), PLCD1(1), PLCE1(3), PLCG2(2), PLCZ1(2), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRKACG(2), PRKCA(2), PRKCG(1), PRKX(1), PTGFR(4), PTK2B(2), RYR1(11), RYR2(8), RYR3(7), SLC8A1(2), SLC8A2(1), SLC8A3(5), TACR1(1), TACR2(2), TACR3(1), TBXA2R(1), TRHR(1), TRPC1(1)	13004097	218	22	216	143	155	12	11	25	14	1	0.369	1.000	1.000
353	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(2), ADCY2(1), ADCY5(3), ADCY7(3), ADCY8(1), ADCY9(2), CSNK1D(1), DRD2(2), EGF(3), EGFR(3), GJA1(1), GNA11(3), GNAQ(1), GNAS(3), GRM1(2), GRM5(1), GUCY1A3(4), GUCY1B3(2), GUCY2C(3), GUCY2D(1), GUCY2F(1), HTR2A(1), ITPR1(1), ITPR2(1), ITPR3(1), KRAS(3), MAP2K1(1), MAP2K5(1), MAP3K2(2), NPR1(1), NPR2(1), PDGFC(2), PDGFD(1), PDGFRA(4), PLCB1(3), PLCB3(1), PLCB4(9), PRKACG(2), PRKCA(2), PRKCG(1), PRKG1(1), PRKG2(3), PRKX(1), RAF1(1), SOS1(1), SOS2(2), TUBA1A(1), TUBA1B(4), TUBA3C(1), TUBA3E(1), TUBA4A(1), TUBB3(2), TUBB4Q(2), TUBB6(2), TUBB8(2)	6433006	106	22	102	61	67	6	7	19	7	0	0.459	1.000	1.000
354	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	202	ACTN1(2), ACTN2(5), ACTN3(2), APC(2), APC2(1), ARHGEF6(3), ARHGEF7(1), ARPC1B(3), BCAR1(1), BDKRB2(3), CD14(1), CHRM1(1), CHRM2(1), CHRM3(2), CHRM4(1), CHRM5(1), CRK(1), CRKL(1), CYFIP1(3), CYFIP2(2), DIAPH2(2), EGF(3), EGFR(3), F2(1), F2R(1), FGD3(2), FGF11(1), FGF12(1), FGF14(1), FGF4(1), FGF5(1), FGFR2(5), FGFR3(1), FN1(2), GNA13(1), GRLF1(1), IQGAP1(1), IQGAP2(2), IQGAP3(2), ITGA10(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA6(1), ITGA7(3), ITGA8(4), ITGAD(1), ITGAE(1), ITGAL(2), ITGAM(3), ITGAV(2), ITGAX(1), ITGB4(4), ITGB5(2), ITGB6(3), ITGB8(1), KRAS(3), LIMK2(2), MAP2K1(1), MOS(2), MYH10(2), MYH14(2), MYLK(2), MYLK2(3), NCKAP1(1), NCKAP1L(3), PAK2(1), PAK3(1), PAK7(1), PDGFRA(4), PIK3CB(2), PIK3CD(1), PIK3R2(1), PIP4K2A(1), PIP5K1A(2), PIP5K1B(1), PIP5K1C(1), PTK2(2), PXN(1), RAF1(1), ROCK2(1), SOS1(1), SOS2(2), SSH1(2), SSH2(2), TIAM1(6), TIAM2(4), VAV1(3), WAS(1)	13466036	164	22	163	87	110	9	5	24	15	1	0.355	1.000	1.000
355	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(2), ADCY2(1), ADCY5(3), ADCY7(3), ADCY8(1), ADCY9(2), ADRA1A(1), ADRA1D(1), ANXA6(1), ARRB2(1), ATP1A4(2), ATP2A2(1), ATP2A3(3), ATP2B1(1), ATP2B2(3), ATP2B3(1), CACNA1A(3), CACNA1B(4), CACNA1C(5), CACNA1D(2), CACNA1E(9), CACNA1S(3), CAMK2A(1), CAMK4(1), CASQ1(3), CHRM1(1), CHRM2(1), CHRM3(2), CHRM4(1), CHRM5(1), GJA1(1), GJA5(1), GNA11(3), GNAO1(1), GNAQ(1), GNB5(1), GRK4(1), GRK6(1), ITPR1(1), ITPR2(1), ITPR3(1), KCNB1(5), KCNJ5(1), PLCB3(1), PRKAR1B(1), PRKCA(2), PRKCG(1), PRKCH(3), PRKCQ(2), PRKCZ(1), RGS20(2), RGS3(1), RGS6(2), RGS7(3), RGS9(1), RYR1(11), RYR2(8), RYR3(7), SLC8A1(2), SLC8A3(5)	9097284	136	20	135	99	91	10	9	19	6	1	0.766	1.000	1.000
356	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN1(2), ACTN2(5), ACTN3(2), ARHGAP5(1), BCAR1(1), CD99(1), CDH5(2), CLDN14(2), CLDN2(3), CLDN22(1), CLDN4(1), CTNNA2(4), CTNNA3(4), CTNNB1(1), CTNND1(1), CXCR4(1), F11R(1), GRLF1(1), ITGA4(1), ITGAL(2), ITGAM(3), ITK(3), JAM2(2), MAPK13(1), MLLT4(4), NCF2(1), NOX1(1), NOX3(2), OCLN(1), PIK3CB(2), PIK3CD(1), PIK3R2(1), PLCG2(2), PRKCA(2), PRKCG(1), PTK2(2), PTK2B(2), PTPN11(1), PXN(1), ROCK2(1), SIPA1(2), VAV1(3), VCAM1(2)	6028920	78	20	77	40	51	5	1	9	12	0	0.355	1.000	1.000
357	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(2), ADCY2(1), ADCY5(3), ADCY7(3), ADCY8(1), ADCY9(2), ARRB2(1), ATF4(1), ATP2A2(1), ATP2A3(3), CAMK2A(1), CORIN(2), CRHR1(1), DGKZ(2), ETS2(1), GABPB2(1), GJA1(1), GNAQ(1), GNB5(1), GRK4(1), GRK6(1), GSTO1(1), GUCY1A3(4), IGFBP1(1), IL6(1), ITPR1(1), ITPR2(1), ITPR3(1), MYLK2(3), NFKB1(1), NOS1(3), NOS3(3), PDE4D(1), PLCB3(1), PLCD1(1), PLCG2(2), PRKAR1B(1), PRKCA(2), PRKCH(3), PRKCQ(2), PRKCZ(1), RGS20(2), RGS3(1), RGS6(2), RGS7(3), RGS9(1), RYR1(11), RYR2(8), RYR3(7), SLC8A1(2), SP1(2), TNXB(17)	8496195	121	20	121	78	81	10	9	14	6	1	0.562	1.000	1.000
358	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTG1(1), COL11A1(6), COL11A2(6), COL17A1(1), COL1A1(6), COL1A2(4), COL2A1(6), COL3A1(6), COL4A2(2), COL4A4(10), COL4A6(2), COL5A1(6), COL5A3(8), COL6A1(2), COL6A2(1), COL6A3(7), COL6A6(5), DES(1), DSC1(5), DSC2(1), DSC3(4), DSG1(5), DSG3(4), DSG4(1), FN1(2), GJA1(1), GJA5(1), GJA8(1), GJA9(1), GJC1(2), ITGA6(1), ITGB4(4), KRT1(3), KRT10(3), KRT12(2), KRT13(2), KRT15(1), KRT16(2), KRT17(1), KRT2(1), KRT23(1), KRT24(2), KRT25(2), KRT28(1), KRT31(1), KRT32(1), KRT33A(1), KRT34(1), KRT35(1), KRT36(4), KRT37(1), KRT39(1), KRT4(1), KRT5(2), KRT6B(2), KRT6C(3), KRT7(1), KRT71(3), KRT72(2), KRT74(3), KRT75(1), KRT77(2), KRT78(1), KRT79(2), KRT8(2), KRT85(2), KRT86(1), KRT9(1), LAMA1(3), LAMA2(4), LAMA3(1), LAMA4(1), LAMA5(4), LAMB2(2), LAMB3(2), LAMB4(1), LAMC2(1), LMNA(3), LMNB2(1), RELN(11), THBS1(1), THBS3(1), THBS4(2), TNC(5), TNN(4), TNR(8), TNXB(17), VIM(1), VWF(6)	12283104	253	19	253	118	196	16	4	19	17	1	0.108	1.000	1.000
359	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	126	ABLIM2(1), CXCR4(1), DCC(4), DPYSL2(2), DPYSL5(1), EFNA5(1), EPHA1(3), EPHA2(1), EPHA3(4), EPHA4(3), EPHA6(3), EPHA7(2), EPHB1(6), EPHB3(1), EPHB4(1), EPHB6(2), FYN(1), KRAS(3), L1CAM(2), LIMK2(2), LRRC4C(4), NFATC1(1), NFATC2(3), NFATC4(1), NGEF(1), NRP1(1), NTN4(2), NTNG1(2), PAK2(1), PAK3(1), PAK7(1), PLXNA2(1), PLXNA3(4), PLXNB2(4), PLXNC1(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PTK2(2), RGS3(1), RND1(1), ROBO1(2), ROBO2(1), ROCK2(1), SEMA3A(1), SEMA3C(1), SEMA3F(3), SEMA3G(4), SEMA4A(2), SEMA4D(1), SEMA4F(1), SEMA4G(2), SEMA5A(4), SEMA6B(1), SLIT1(3), SLIT2(6), SLIT3(4), SRGAP2(1), SRGAP3(2), UNC5C(1), UNC5D(4)	9512509	127	19	126	72	87	10	8	14	8	0	0.537	1.000	1.000
360	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(1), CD36(1), CD44(2), COL11A1(6), COL11A2(6), COL1A1(6), COL1A2(4), COL2A1(6), COL3A1(6), COL4A2(2), COL4A4(10), COL4A6(2), COL5A1(6), COL5A3(8), COL6A1(2), COL6A2(1), COL6A3(7), COL6A6(5), FN1(2), FNDC1(3), FNDC4(1), GP9(1), HSPG2(2), ITGA10(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA6(1), ITGA7(3), ITGA8(4), ITGAV(2), ITGB4(4), ITGB5(2), ITGB6(3), ITGB8(1), LAMA1(3), LAMA2(4), LAMA3(1), LAMA4(1), LAMA5(4), LAMB2(2), LAMB3(2), LAMB4(1), LAMC2(1), RELN(11), SDC4(1), SV2A(1), SV2B(5), SV2C(2), THBS1(1), THBS3(1), THBS4(2), TNC(5), TNN(4), TNR(8), TNXB(17), VWF(6)	10986913	197	19	197	92	151	9	4	15	17	1	0.390	1.000	1.000
361	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTG1(1), ACTN1(2), ACTN2(5), ACTN3(2), AKT2(2), AMOTL1(1), ASH1L(3), CASK(3), CLDN14(2), CLDN2(3), CLDN22(1), CLDN4(1), CSDA(2), CTNNA2(4), CTNNA3(4), CTNNB1(1), EPB41L2(5), EPB41L3(2), EXOC3(1), F11R(1), HCLS1(1), INADL(4), JAM2(2), KRAS(3), MAGI1(1), MAGI2(5), MLLT4(4), MYH1(6), MYH10(2), MYH11(3), MYH13(4), MYH14(2), MYH15(7), MYH2(9), MYH3(1), MYH4(5), MYH6(4), MYH7(4), MYH7B(3), MYH8(4), OCLN(1), PARD3(2), PPM1J(1), PPP2R3A(1), PPP2R3B(1), PPP2R4(1), PRKCA(2), PRKCG(1), PRKCH(3), PRKCI(1), PRKCQ(2), PRKCZ(1), PTEN(1), SPTAN1(2), TJAP1(2), TJP3(3), YES1(1)	9509911	146	19	145	83	103	17	8	12	6	0	0.226	1.000	1.000
362	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	150	AKT2(2), CBL(1), CBLB(1), CBLC(5), CCND3(1), CREBBP(3), CSF2RA(1), CSF2RB(1), EP300(2), GH2(1), GHR(1), IFNA14(1), IFNA16(1), IFNA6(1), IFNA7(1), IFNAR2(1), IL10RA(1), IL12A(1), IL12RB1(2), IL12RB2(1), IL20(1), IL20RA(1), IL21(1), IL21R(3), IL23R(1), IL26(1), IL28RA(1), IL2RA(1), IL2RB(2), IL2RG(1), IL5RA(1), IL6(1), IL6R(1), IL6ST(1), IL7R(3), IL9R(1), IRF9(1), JAK1(1), JAK2(1), JAK3(1), LEPR(3), LIFR(4), OSMR(7), PIAS2(1), PIK3CB(2), PIK3CD(1), PIK3R2(1), PRLR(1), PTPN11(1), SOCS2(1), SOCS4(1), SOCS5(1), SOCS7(1), SOS1(1), SOS2(2), SPRED1(1), SPRY1(2), SPRY3(1), STAM(2), STAT3(3), STAT4(2), STAT5B(1), STAT6(1), TPO(3)	7164086	98	19	98	48	65	7	5	10	11	0	0.421	1.000	1.000
363	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	CACNA1A(3), CRHR1(1), GNA11(3), GNA13(1), GNAO1(1), GNAQ(1), GNAS(3), GRIA1(5), GRIA2(1), GRID2(2), GRM1(2), GRM5(1), GUCY1A3(4), GUCY1B3(2), GUCY2C(3), GUCY2D(1), GUCY2F(1), IGF1(1), IGF1R(4), ITPR1(1), ITPR2(1), ITPR3(1), KRAS(3), MAP2K1(1), NOS1(3), NOS3(3), NPR1(1), NPR2(1), PLA2G2A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCB1(3), PLCB3(1), PLCB4(9), PRKCA(2), PRKCG(1), PRKG1(1), PRKG2(3), RAF1(1), RYR1(11)	5337575	94	19	91	60	59	7	5	15	8	0	0.713	1.000	1.000
364	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTN2(5), ACTN3(2), DES(1), DMD(6), MYBPC1(4), MYBPC2(1), MYBPC3(2), MYH3(1), MYH6(4), MYH7(4), MYH8(4), MYL1(1), MYOM1(1), NEB(11), TNNT2(1), TPM1(1), TTN(82), VIM(1)	6348265	132	19	131	62	96	14	3	11	6	2	0.202	1.000	1.000
365	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(3), CTCFL(3), EHMT1(2), EHMT2(1), EZH1(2), EZH2(1), FBXO11(2), MLL(4), MLL2(5), MLL3(7), MLL4(6), MLL5(2), NSD1(1), PRDM2(2), PRDM7(2), PRDM9(2), PRMT5(1), PRMT8(2), SATB1(1), SETD1A(2), SETD2(2), SMYD3(1), STK38(1), WHSC1(1)	5836156	56	18	56	26	35	6	3	8	4	0	0.573	1.000	1.000
366	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(1), ADORA3(2), ADRA1A(1), ADRA1D(1), AGTR1(2), AGTR2(1), BDKRB2(3), BRS3(2), CCBP2(2), CCR1(2), CCR5(2), CCR8(1), CCR9(1), CHRM1(1), CHRM2(1), CHRM3(2), CHRM4(1), CHRM5(1), CMKLR1(1), CX3CR1(1), CXCR4(1), DRD2(2), DRD5(3), F2R(1), F2RL1(2), FPR1(4), FSHR(2), GPR174(2), GPR37L1(1), GPR50(1), GPR6(1), GPR63(1), GPR85(1), HCRTR2(1), HRH1(1), HTR1A(1), HTR1E(1), HTR2A(1), HTR5A(1), LHCGR(2), MC3R(1), MC5R(1), MTNR1B(1), NMUR1(1), NMUR2(2), NPY1R(4), NPY2R(3), NPY5R(4), NTSR1(1), NTSR2(1), OPRK1(3), OPRM1(2), OR11A1(1), OR1C1(2), P2RY1(2), P2RY10(1), PPYR1(1), PTGDR(3), PTGER2(1), PTGFR(4), PTGIR(1), RGR(1), RHO(1), SSTR3(1), TBXA2R(1), TRHR(1)	5952599	104	18	104	82	67	13	2	16	6	0	0.367	1.000	1.000
367	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(2), ADCY2(1), ADCY5(3), ADCY7(3), ADCY8(1), ADCY9(2), ADSL(2), ADSSL1(1), AK7(3), ALLC(1), AMPD1(3), AMPD2(2), AMPD3(3), APRT(1), CANT1(1), ENPP1(1), ENPP3(1), ENTPD1(2), ENTPD2(1), ENTPD3(1), ENTPD5(1), ENTPD6(1), GUCY1A3(4), GUCY1B3(2), GUCY2C(3), GUCY2D(1), GUCY2F(1), IMPDH1(1), NPR1(1), NPR2(1), NT5C1B(4), NT5E(1), PAPSS1(1), PAPSS2(3), PDE10A(1), PDE11A(2), PDE1A(3), PDE1C(4), PDE2A(4), PDE4C(2), PDE4D(1), PDE7B(3), PDE8B(2), PFAS(1), PKLR(3), PKM2(1), POLA2(2), POLE(2), POLR1A(2), POLR1B(1), POLR2A(2), POLR3A(2), POLR3K(1), PRIM1(1), PRIM2(3), PRPS1L1(2), PRPS2(1), XDH(9)	8020413	115	18	115	50	82	9	4	11	9	0	0.0349	1.000	1.000
368	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	CCNB3(3), CCND3(1), CCNE1(1), CCNE2(3), CDAN1(1), CDH1(1), CDKN2A(2), CHEK2(1), DTX4(1), E2F1(1), EP300(2), ESPL1(3), HDAC3(1), HDAC4(2), HDAC5(1), MAD1L1(1), MCM2(1), MCM4(2), MCM5(1), MPEG1(3), ORC6L(1), RB1(1), SKP2(1), TBC1D8(2), TP53(2)	5398494	39	17	38	19	22	4	1	7	5	0	0.495	1.000	1.000
369	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	INPP5A(1), INPP5B(1), INPPL1(1), ITPK1(1), PI4KA(6), PIK3CB(2), PIK3CD(1), PIP4K2A(1), PIP5K1A(2), PIP5K1B(1), PIP5K1C(1), PLCB1(3), PLCB3(1), PLCB4(9), PLCD1(1), PLCE1(3), PLCG2(2), PLCZ1(2), PTEN(1), SYNJ1(2), SYNJ2(3)	3613237	45	17	44	22	23	2	3	12	5	0	0.608	1.000	1.000
370	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CDS1(1), DGKA(1), DGKB(3), DGKD(2), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), INPP5A(1), INPP5B(1), INPPL1(1), ITPK1(1), ITPR1(1), ITPR2(1), ITPR3(1), PI4KA(6), PIK3C2B(1), PIK3C2G(4), PIK3CB(2), PIK3CD(1), PIK3R2(1), PIP4K2A(1), PIP5K1A(2), PIP5K1B(1), PIP5K1C(1), PLCB1(3), PLCB3(1), PLCB4(9), PLCD1(1), PLCE1(3), PLCG2(2), PLCZ1(2), PRKCA(2), PRKCG(1), PTEN(1), SYNJ1(2), SYNJ2(3)	6057252	71	17	70	39	44	2	4	14	7	0	0.677	1.000	1.000
371	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ANAPC1(2), ANAPC5(2), ANAPC7(1), CCNB3(3), CCND3(1), CCNE1(1), CCNE2(3), CDC27(1), CDKN2A(2), CHEK2(1), CREBBP(3), E2F1(1), EP300(2), ESPL1(3), FZR1(1), MAD1L1(1), MCM2(1), MCM4(2), MCM5(1), ORC6L(1), RB1(1), SKP2(1), SMC1B(2), TP53(2)	6725765	39	17	38	21	21	3	3	7	5	0	0.690	1.000	1.000
372	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(2), APC2(1), AXIN1(2), BTRC(1), CAMK2A(1), CCND3(1), CHD8(5), CREBBP(3), CSNK1A1L(2), CTNNB1(1), DAAM1(1), DAAM2(1), DKK1(1), DKK2(2), DVL3(1), EP300(2), FBXW11(1), FZD1(1), FZD5(1), LRP5(5), LRP6(3), MAPK8(1), MAPK9(3), MMP7(2), NFATC1(1), NFATC2(3), NFATC4(1), PLCB1(3), PLCB3(1), PLCB4(9), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRICKLE1(1), PRICKLE2(1), PRKACG(2), PRKCA(2), PRKCG(1), PRKX(1), ROCK2(1), SENP2(1), SFRP2(1), SFRP4(1), TCF7(1), TCF7L1(1), TCF7L2(2), TP53(2), WIF1(1), WNT10A(1), WNT10B(1), WNT16(1), WNT2(2), WNT3(1), WNT3A(1), WNT5A(1), WNT5B(1), WNT7A(3), WNT7B(2), WNT8A(1)	7860081	100	17	99	56	58	6	6	15	15	0	0.726	1.000	1.000
373	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(2), ADCY2(1), ADCY5(3), ADCY7(3), ADCY8(1), ADCY9(2), ATF4(1), CACNA1C(5), CACNA1D(2), CACNA1F(1), CACNA1S(3), CAMK2A(1), EGFR(3), GNA11(3), GNAQ(1), GNAS(3), ITPR1(1), ITPR2(1), ITPR3(1), KRAS(3), MAP2K1(1), MAP2K6(1), MAP2K7(1), MAP3K2(2), MAP3K4(3), MAPK13(1), MAPK8(1), MAPK9(3), PLA2G2A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCB1(3), PLCB3(1), PLCB4(9), PLD2(1), PRKACG(2), PRKCA(2), PRKX(1), PTK2B(2), RAF1(1), SOS1(1), SOS2(2)	6166827	86	17	84	57	55	4	5	15	7	0	0.797	1.000	1.000
374	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	CCND3(1), CCNE1(1), CCNE2(3), CDKN2A(2), E2F1(1), MCM2(1), MCM4(2), MCM5(1), MYT1(2), ORC6L(1), POLA2(2), POLE(2), PRIM1(1), RB1(1), RPA2(1), TNXB(17), TP53(2)	3908664	41	16	40	24	27	1	2	4	7	0	0.712	1.000	1.000
375	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(2), ADCY2(1), ADCY5(3), ADCY7(3), ADCY8(1), ADCY9(2), AKAP1(1), AKAP11(2), AKAP3(2), AKAP4(1), AKAP6(2), AKAP8(1), AKAP9(2), GNA11(3), GNA13(1), GNAO1(1), GNAQ(1), GNB5(1), ITPR1(1), KRAS(3), PDE1A(3), PDE1B(2), PDE1C(4), PDE4C(2), PDE4D(1), PDE7B(3), PDE8B(2), PLCB3(1), PPP3CA(1), PPP3CC(1), PRKACG(2), PRKAR1B(1), PRKCA(2), PRKCG(1), PRKCH(3), PRKCI(1), PRKCQ(2), PRKCZ(1)	5716816	67	16	66	54	43	5	3	14	2	0	0.976	1.000	1.000
376	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(2), CD14(1), CD1A(1), CD1B(1), CD1C(3), CD1D(2), CD2(1), CD22(2), CD33(1), CD34(1), CD36(1), CD38(2), CD3D(1), CD44(2), CD5(1), CD55(1), CD8B(1), CR1(4), CR2(3), CSF1R(3), CSF2RA(1), DNTT(1), FLT3(2), GP9(1), HLA-DRA(2), IL1R1(2), IL1R2(1), IL2RA(1), IL5RA(1), IL6(1), IL6R(1), IL7R(3), IL9R(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA6(1), ITGAM(3), KIT(4), MME(1), THPO(1), TPO(3)	3978287	68	16	67	42	44	6	4	8	6	0	0.777	1.000	1.000
377	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	125	CD247(1), FAS(1), FASLG(3), FCGR3A(1), FYN(1), HLA-B(1), IFNA14(1), IFNA16(1), IFNA6(1), IFNA7(1), IFNAR2(1), ITGAL(2), KIR2DL1(4), KIR2DL3(2), KIR2DL4(1), KIR3DL1(4), KLRC2(1), KLRD1(1), KLRK1(2), KRAS(3), LCK(1), MAP2K1(1), NCR1(1), NCR2(3), NFATC1(1), NFATC2(3), NFATC4(1), PIK3CB(2), PIK3CD(1), PIK3R2(1), PLCG2(2), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRF1(3), PRKCA(2), PRKCG(1), PTK2B(2), PTPN11(1), RAF1(1), SH2D1A(1), SHC3(1), SOS1(1), SOS2(2), SYK(1), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(1), TYROBP(1), ULBP3(1), VAV1(3)	5537346	79	16	79	48	48	6	4	12	9	0	0.802	1.000	1.000
378	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	73	AKT2(2), BTK(3), FCER1A(1), FYN(1), KRAS(3), MAP2K1(1), MAP2K6(1), MAP2K7(1), MAPK13(1), MAPK8(1), MAPK9(3), MS4A2(1), PIK3CB(2), PIK3CD(1), PIK3R2(1), PLA2G2A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCG2(2), PRKCA(2), RAF1(1), SOS1(1), SOS2(2), SYK(1), VAV1(3)	3528424	42	16	42	22	23	2	2	8	7	0	0.735	1.000	1.000
379	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(2), AGTR2(1), ATP8A1(3), BDKRB2(3), BRS3(2), CCR1(2), CCR5(2), CCR8(1), CX3CR1(1), CXCR4(1), CXCR6(1), FPR1(4), FSHR(2), LHCGR(2), MC3R(1), MC5R(1), NPY1R(4), NPY2R(3), NPY5R(4), NTSR1(1), NTSR2(1), OPRK1(3), OPRM1(2), PPYR1(1), SSTR3(1), TACR1(1), TACR2(2), TACR3(1), TRHR(1)	2578626	54	16	54	36	38	6	0	8	2	0	0.167	1.000	1.000
380	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVRL1(1), BMPR2(1), CDS1(1), CLK2(1), DGKA(1), DGKB(3), DGKD(2), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), INPP5A(1), INPPL1(1), MOS(2), NEK1(1), PIK3C2B(1), PIK3C2G(4), PIK3CB(2), PLCB1(3), PLCB3(1), PLCB4(9), PLCD1(1), PLCG2(2), PLK3(1), PRKACG(2), PRKAR1B(1), PRKCA(2), PRKCG(1), PRKCH(3), PRKCQ(2), PRKCZ(1), PRKG1(1), RAF1(1), RPS6KA2(1), RPS6KA4(2), RPS6KB1(1)	5497042	64	16	63	42	44	0	6	7	7	0	0.925	1.000	1.000
381	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT2(2), CDKN2A(2), CREB5(2), ERBB4(6), GAB1(1), IGF1(1), IGFBP1(1), INPPL1(1), IRS1(1), IRS4(2), NOLC1(1), PAK2(1), PAK3(1), PAK7(1), PARD3(2), PIK3CD(1), PREX1(1), PTEN(1), PTK2(2), PTPN1(1), RPS6KA2(1), RPS6KB1(1), SLC2A4(1), SOS1(1), SOS2(2), TSC1(1), TSC2(1)	3803599	39	16	39	22	17	6	2	6	8	0	0.849	1.000	1.000
382	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ACTN1(2), AKT2(2), ARHGEF6(3), ARHGEF7(1), BCAR1(1), CDKN2A(2), CRK(1), FYN(1), GRB7(1), GRLF1(1), ITGA10(1), ITGA4(1), ITGA5(1), ITGA6(1), ITGA7(3), ITGA8(4), MAP2K7(1), MAPK8(1), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(2), MAPK9(3), MYLK(2), MYLK2(3), P4HB(1), PAK2(1), PAK3(1), PAK7(1), PIK3CB(2), PKLR(3), PLCG2(2), PTEN(1), PTK2(2), RAF1(1), RHO(1), ROCK2(1), SOS1(1), SOS2(2), TLN1(1), WAS(1), ZYX(1)	5977061	66	16	66	34	35	2	1	16	12	0	0.661	1.000	1.000
383	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	BCL2(1), CAMK4(1), CREBBP(3), EP300(2), FCER1A(1), FCGR3A(1), GATA3(2), GRLF1(1), ICOS(1), IL2RA(1), IL6(1), ITK(3), MAP2K7(1), MAPK8(1), MAPK9(3), MEF2B(1), MYF5(2), NFATC1(1), NFATC2(3), NFATC4(1), NPPB(1), NUP214(2), P2RX7(1), PPP3CB(1), PPP3CC(1), PTPRC(2), SLA(1), SP1(2), TRAF2(1), TRPV6(5), VAV1(3), XPO5(1)	4477976	52	15	52	24	36	2	4	5	5	0	0.289	1.000	1.000
384	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(4), ADH1C(3), ADH6(2), ADH7(1), AGPAT1(2), AGPAT4(1), AKR1A1(1), AKR1B1(1), ALDH9A1(1), CEL(1), DGKA(1), DGKB(3), DGKD(2), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), GK(1), GLA(1), GLB1(2), LCT(3), LIPF(4), LIPG(1), PNLIPRP1(2), PNLIPRP2(1), PPAP2C(1)	2374123	48	15	46	24	35	4	2	5	2	0	0.287	1.000	1.000
385	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AKT2(2), APAF1(1), BAX(1), BCL2(1), BIRC3(1), CAPN2(2), CASP8(1), CFLAR(1), CSF2RB(1), DFFA(1), DFFB(1), FAS(1), FASLG(3), IL1R1(2), IL1RAP(1), IRAK2(2), NFKB1(1), NTRK1(4), PIK3CB(2), PIK3CD(1), PIK3R2(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRKACG(2), PRKAR1B(1), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(1), TP53(2), TRAF2(1)	4091469	45	15	45	30	24	0	5	5	11	0	0.934	1.000	1.000
386	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	CADM1(1), CADM3(2), CD2(1), CD22(2), CD276(1), CD34(1), CD6(2), CD86(1), CD8B(1), CD99(1), CDH1(1), CDH15(1), CDH2(1), CDH4(4), CDH5(2), CLDN14(2), CLDN2(3), CLDN22(1), CLDN4(1), CNTN1(2), CNTN2(1), CNTNAP1(1), CNTNAP2(4), F11R(1), HLA-B(1), HLA-DPB1(1), HLA-DQA1(2), HLA-DQB1(1), HLA-DRA(2), ICOS(1), ITGA4(1), ITGA6(1), ITGA8(4), ITGAL(2), ITGAM(3), ITGAV(2), ITGB8(1), JAM2(2), L1CAM(2), MAG(1), NEGR1(2), NEO1(4), NFASC(2), NRCAM(1), NRXN1(3), NRXN2(2), NRXN3(2), OCLN(1), PDCD1(1), PDCD1LG2(2), PTPRC(2), PTPRF(2), SDC4(1), SELE(9), SELP(1), SELPLG(1), SIGLEC1(2), VCAM1(2), VCAN(1)	7130436	106	15	106	44	81	7	1	7	10	0	0.0245	1.000	1.000
387	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(2), ADCY2(1), ADCY5(3), ADCY7(3), ADCY8(1), ADCY9(2), CAMK2A(1), CREB3L2(1), CREBBP(3), CTNNB1(1), DVL3(1), EDN1(2), EP300(2), FZD1(1), FZD5(1), GNAO1(1), GNAQ(1), GNAS(3), KIT(4), KRAS(3), MAP2K1(1), PLCB1(3), PLCB3(1), PLCB4(9), PRKACG(2), PRKCA(2), PRKCG(1), PRKX(1), RAF1(1), TCF7(1), TCF7L1(1), TCF7L2(2), WNT10A(1), WNT10B(1), WNT16(1), WNT2(2), WNT3(1), WNT3A(1), WNT5A(1), WNT5B(1), WNT7A(3), WNT7B(2), WNT8A(1)	5281570	77	15	76	49	47	6	7	13	4	0	0.723	1.000	1.000
388	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ACTG1(1), ARHGEF2(2), CD14(1), CDH1(1), CTNNB1(1), FYN(1), HCLS1(1), NCL(1), OCLN(1), PRKCA(2), ROCK2(1), TLR4(1), TLR5(4), TUBA1A(1), TUBA1B(4), TUBA3C(1), TUBA3E(1), TUBA4A(1), TUBB3(2), TUBB4Q(2), TUBB6(2), TUBB8(2), WAS(1)	2588153	35	15	34	22	20	2	4	7	2	0	0.758	1.000	1.000
389	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ACTG1(1), ARHGEF2(2), CD14(1), CDH1(1), CTNNB1(1), FYN(1), HCLS1(1), NCL(1), OCLN(1), PRKCA(2), ROCK2(1), TLR4(1), TLR5(4), TUBA1A(1), TUBA1B(4), TUBA3C(1), TUBA3E(1), TUBA4A(1), TUBB3(2), TUBB4Q(2), TUBB6(2), TUBB8(2), WAS(1)	2588153	35	15	34	22	20	2	4	7	2	0	0.758	1.000	1.000
390	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CLK2(1), COL2A1(6), DHX16(1), DHX38(1), DHX8(1), DICER1(3), GIPC1(1), LOC440563(1), LSM7(1), NONO(1), POLR2A(2), PRPF8(2), PTBP2(1), SF3A1(1), SF3A2(1), SF3A3(1), SF3B1(2), SF3B2(2), SF4(1), SFRS16(2), SFRS7(1), SNRPB(1), SRPK1(3), SRPK2(1), SRRM1(1)	5255801	39	15	38	16	23	8	2	1	5	0	0.420	1.000	1.000
391	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(2), ADH1B(4), ADH1C(3), ADH5(1), ADH6(2), ADH7(1), AKR1C2(1), AKR1C4(1), ALDH3B2(1), CYP1A1(3), CYP1A2(1), CYP2B6(3), CYP2C18(2), CYP2C19(2), CYP2C8(2), CYP2C9(3), CYP2E1(2), CYP2F1(1), CYP2S1(1), CYP3A4(3), CYP3A5(1), GSTA1(1), GSTA5(1), UGT1A10(3), UGT1A3(1), UGT1A4(3), UGT1A5(1), UGT2B10(1), UGT2B11(1), UGT2B15(4), UGT2B28(2), UGT2B4(2), UGT2B7(1)	2789578	61	14	59	32	44	1	7	4	5	0	0.265	1.000	1.000
392	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(3), DLL1(1), DTX2(2), DTX3L(1), DTX4(1), DVL3(1), EP300(2), JAG1(1), MAML3(1), NCSTN(1), NOTCH1(1), NOTCH2(11), NOTCH3(4), NOTCH4(8), SNW1(1)	3391505	39	14	39	22	20	2	2	12	3	0	0.818	1.000	1.000
393	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	97	AKT2(2), CASP8(1), CD14(1), CD86(1), IFNA14(1), IFNA16(1), IFNA6(1), IFNA7(1), IFNAR2(1), IL12A(1), IL6(1), IRF5(1), LBP(1), MAP2K1(1), MAP2K6(1), MAP2K7(1), MAPK13(1), MAPK8(1), MAPK9(3), NFKB1(1), PIK3CB(2), PIK3CD(1), PIK3R2(1), TLR1(2), TLR2(1), TLR4(1), TLR5(4), TLR7(1), TLR8(1), TLR9(1), TRAF6(1)	4396100	39	14	39	29	23	2	2	6	6	0	0.949	1.000	1.000
394	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT2(2), CARD11(8), CBL(1), CBLB(1), CBLC(5), CD247(1), CD3D(1), CD8B(1), FYN(1), GRAP2(1), ICOS(1), ITK(3), KRAS(3), LCK(1), MALT1(1), NFATC1(1), NFATC2(3), NFATC4(1), NFKB1(1), PAK2(1), PAK3(1), PAK7(1), PDCD1(1), PIK3CB(2), PIK3CD(1), PIK3R2(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRKCQ(2), PTPRC(2), RASGRP1(1), SOS1(1), SOS2(2), VAV1(3)	4978877	60	14	60	36	35	4	5	7	9	0	0.852	1.000	1.000
395	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(2), ADCY8(1), ATF4(1), CACNA1C(5), CAMK2A(1), CAMK4(1), CREBBP(3), EP300(2), GNAQ(1), GRIA1(5), GRIA2(1), GRIN1(1), GRIN2A(7), GRIN2B(3), GRM1(2), GRM5(1), ITPR1(1), ITPR2(1), ITPR3(1), KRAS(3), MAP2K1(1), PLCB1(3), PLCB3(1), PLCB4(9), PPP1R1A(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRKACG(2), PRKCA(2), PRKCG(1), PRKX(1), RAF1(1), RPS6KA2(1), RPS6KA6(2)	4803490	72	14	71	48	46	3	8	10	5	0	0.798	1.000	1.000
396	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	130	ACACB(2), AKT2(2), CBL(1), CBLB(1), CBLC(5), CRK(1), CRKL(1), EIF4EBP1(1), EXOC7(2), FASN(2), FOXO1(1), G6PC2(1), GCK(5), GYS1(1), GYS2(2), INSR(7), IRS1(1), IRS4(2), KRAS(3), LIPE(2), MAP2K1(1), MAPK8(1), MAPK9(3), MKNK2(1), PCK1(3), PDE3A(1), PHKA1(3), PHKB(1), PIK3CB(2), PIK3CD(1), PIK3R2(1), PKLR(3), PKM2(1), PPARGC1A(2), PPP1R3A(1), PRKAA2(1), PRKACG(2), PRKAG3(1), PRKAR1B(1), PRKCI(1), PRKCZ(1), PRKX(1), PTPN1(1), PTPRF(2), PYGB(1), PYGM(1), RAF1(1), RHEB(1), RPS6KB1(1), SH2B2(1), SHC3(1), SLC2A4(1), SOCS2(1), SOCS4(1), SORBS1(1), SOS1(1), SOS2(2), TSC1(1), TSC2(1)	7863193	95	14	95	46	57	10	4	15	9	0	0.381	1.000	1.000
397	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	89	BCAR1(1), CAPN11(2), CAPN2(2), CAPN3(1), CAPN6(2), CAPN9(2), CAPNS1(1), CRK(1), FYN(1), GIT2(3), ITGA10(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA6(1), ITGA7(3), ITGA8(4), ITGAD(1), ITGAE(1), ITGAL(2), ITGAM(3), ITGAV(2), ITGAX(1), ITGB4(4), ITGB5(2), ITGB6(3), ITGB8(1), MAP2K1(1), MAP2K6(1), MYLK2(3), PAK2(1), PAK3(1), PIK3R2(1), PTK2(2), PXN(1), RHO(1), ROCK2(1), SDCCAG8(1), SHC3(1), SORBS1(1), SOS1(1), TLN1(1), ZYX(1)	6494704	67	14	67	38	43	2	1	12	8	1	0.605	1.000	1.000
398	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(2), ADCY2(1), ADCY5(3), ADCY7(3), ADCY8(1), ADSL(2), ALLC(1), AMPD1(3), AMPD2(2), AMPD3(3), APRT(1), ATP5F1(1), ATP5J(1), CANT1(1), ENPP1(1), ENPP3(1), ENTPD1(2), ENTPD2(1), GUCY1A3(4), GUCY1B3(2), GUCY2C(3), GUCY2D(1), GUCY2F(1), IMPDH1(1), NPR1(1), NPR2(1), NT5E(1), PAPSS1(1), PAPSS2(3), PDE1A(3), PDE4C(2), PDE4D(1), PDE6B(3), PDE6C(1), PDE7B(3), PFAS(1), PKLR(3), PKM2(1), POLE(2), POLG(1), POLL(1), POLQ(2), POLR1B(1), POLR2A(2), PRPS1L1(2), PRPS2(1)	6273582	79	14	79	37	58	8	2	5	6	0	0.0801	1.000	1.000
399	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(2), CCR5(2), CELSR1(4), CELSR2(8), CELSR3(1), CHRM2(1), CHRM3(2), EMR3(4), F2R(1), FSHR(2), GHRHR(1), GPR116(2), GPR133(1), GPR55(1), GPR56(1), GPR61(2), GRM1(2), LGR6(5), LPHN2(3), LPHN3(1), NTSR1(1), OR2M4(1), OR8G2(2), PTGFR(4), SMO(3)	3258165	57	13	57	35	38	5	3	4	7	0	0.284	1.000	1.000
400	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS2(2), ADH1A(2), ADH1B(4), ADH1C(3), ADH5(1), ADH6(2), ADH7(1), AKR1A1(1), ALDH3B2(1), ALDH7A1(2), ALDH9A1(1), ALDOB(1), ALDOC(1), ENO2(1), G6PC2(1), GCK(5), GPI(2), HK2(1), HK3(3), LDHA(1), LDHAL6B(3), PGK2(3), PKLR(3), PKM2(1)	2876834	46	13	44	29	34	2	2	6	2	0	0.532	1.000	1.000
401	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAD8(1), ADH1A(2), ADH1B(4), ADH1C(3), ADH5(1), ADH6(2), ADH7(1), AKR1C4(1), ALDH7A1(2), ALDH9A1(1), CEL(1), CYP7A1(1), LIPA(3)	1564926	24	13	22	19	15	4	1	4	0	0	0.856	1.000	1.000
402	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), ARSD(1), ARSE(1), CYP11B1(1), CYP11B2(2), CYP19A1(3), HEMK1(1), HSD11B1(1), HSD3B1(1), HSD3B2(1), METTL2B(2), METTL6(1), PRMT5(1), PRMT8(2), STS(1), SULT2A1(1), SULT2B1(1), UGT1A10(3), UGT1A3(1), UGT1A4(3), UGT1A5(1), UGT2B10(1), UGT2B11(1), UGT2B15(4), UGT2B28(2), UGT2B4(2), UGT2B7(1)	2433551	41	13	41	20	28	3	6	1	3	0	0.243	1.000	1.000
403	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(1), AGPAT1(2), AGPAT4(1), CDS1(1), CHAT(1), DGKA(1), DGKB(3), DGKD(2), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), GNPAT(1), GPD1(1), MYST3(4), MYST4(5), PLA2G2A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLD2(1), PNPLA3(1), PPAP2C(1)	3211612	40	13	40	21	26	2	2	4	6	0	0.591	1.000	1.000
404	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	FARSA(1), GARS(1), HARS(1), HARS2(1), IARS(2), IARS2(2), KARS(1), LARS(2), MARS(3), MTFMT(1), NARS(1), NARS2(2), QARS(2), RARS(2), RARS2(2), SARS(2), SARS2(1), TARS2(1), VARS(4), VARS2(1)	2712456	33	13	33	15	20	5	0	4	4	0	0.338	1.000	1.000
405	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL2(1), AKT2(2), BTC(1), CAMK2A(1), CBL(1), CBLB(1), CBLC(5), CRK(1), CRKL(1), EGF(3), EGFR(3), EIF4EBP1(1), ERBB4(6), GAB1(1), KRAS(3), MAP2K1(1), MAP2K7(1), MAPK8(1), MAPK9(3), NRG1(3), PAK2(1), PAK3(1), PAK7(1), PIK3CB(2), PIK3CD(1), PIK3R2(1), PLCG2(2), PRKCA(2), PRKCG(1), PTK2(2), RAF1(1), RPS6KB1(1), SHC3(1), SOS1(1), SOS2(2), STAT5B(1)	5045304	61	13	61	34	35	3	4	13	6	0	0.849	1.000	1.000
406	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(2), BDKRB2(3), C1QA(1), C1QB(1), C1QC(1), C1R(1), C1S(3), C2(3), C3(4), C5AR1(2), C6(1), C7(5), C8A(3), C8B(1), CD55(1), CFB(3), CFH(4), CR1(4), CR2(3), F11(1), F12(1), F13A1(2), F13B(1), F2(1), F2R(1), F7(1), F8(2), F9(1), FGA(3), FGB(1), KLKB1(1), KNG1(1), MASP2(2), MBL2(1), PLG(1), PROC(1), PROS1(1), SERPINA1(1), SERPINA5(2), SERPINC1(1), SERPIND1(1), SERPINE1(1), SERPINF2(2), SERPING1(4), THBD(2), VWF(6)	4420459	89	13	88	44	58	7	4	13	7	0	0.496	1.000	1.000
407	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	61	AKT2(2), BLNK(1), BTK(3), CARD11(8), CD22(2), CR2(3), KRAS(3), LILRB3(1), MALT1(1), NFATC1(1), NFATC2(3), NFATC4(1), NFKB1(1), PIK3CB(2), PIK3CD(1), PIK3R2(1), PLCG2(2), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), RASGRP3(2), SYK(1), VAV1(3)	3646829	46	13	46	23	29	3	4	4	6	0	0.443	1.000	1.000
408	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(1), ADCY8(1), CACNA1A(3), CACNA1B(4), GNAS(3), GRM4(1), ITPR3(1), KCNB1(5), PDE1A(3), PRKACG(2), PRKX(1), SCNN1B(2), SCNN1G(2), TAS1R1(2), TAS1R2(1), TAS1R3(1), TAS2R1(1), TAS2R10(2), TAS2R13(2), TAS2R16(1), TAS2R38(2), TAS2R39(2), TAS2R41(1), TAS2R60(2), TAS2R7(1), TAS2R9(1), TRPM5(2)	2768149	50	13	50	35	36	2	5	5	2	0	0.461	1.000	1.000
409	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	BAX(1), BTK(3), CAD(2), CASP8(1), DAXX(2), DEDD2(2), DFFA(1), EGFR(3), FAF1(1), FAIM2(1), MAP2K7(1), MAP3K5(1), MAPK8(1), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(2), MAPK9(3), NFKB1(1), NFKBIL1(1), PTPN13(1), TP53(2), TRAF2(1)	3551653	36	13	36	17	21	1	1	8	5	0	0.666	1.000	1.000
410	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT2(2), DRD2(2), EGFR(3), ITPR1(1), ITPR2(1), ITPR3(1), KCNJ5(1), PI3(2), PIK3CB(2), PLCB1(3), PLCB3(1), PLCB4(9), RAF1(1), RGS20(2), SOS1(1), SOS2(2), STAT3(3)	2868884	37	13	36	19	19	2	3	8	5	0	0.639	1.000	1.000
411	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(3), AGTR1(2), AGTR2(1), CMA1(2), COL4A2(2), COL4A3(4), COL4A4(10), COL4A5(3), COL4A6(2), REN(2)	1234589	31	12	31	13	26	0	1	3	1	0	0.880	1.000	1.000
412	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(2), AMY2A(1), AMY2B(1), ASCC3(2), ATP13A2(1), DDX23(1), DDX4(2), DDX47(1), DDX56(2), ENPP1(1), ENPP3(1), EP400(1), ERCC2(1), G6PC2(1), GAA(1), GBA(2), GBA3(1), GBE1(1), GCK(5), GPI(2), GYS1(1), GYS2(2), HK2(1), HK3(3), IFIH1(1), MGAM(12), MOV10L1(8), NUDT8(1), PYGB(1), PYGM(1), RAD54B(2), SETX(2), SI(8), SMARCA2(2), UGT1A10(3), UGT1A3(1), UGT1A4(3), UGT1A5(1), UGT2B10(1), UGT2B11(1), UGT2B15(4), UGT2B28(2), UGT2B4(2), UGT2B7(1)	5985893	94	12	93	36	67	6	6	5	10	0	0.0365	1.000	1.000
413	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1C(2), ACVRL1(1), AMHR2(4), BMP5(1), BMP6(1), BMPR2(1), CREBBP(3), EP300(2), GDF5(2), GDF7(2), ID2(2), INHBA(1), INHBC(2), LEFTY1(1), LEFTY2(1), LTBP1(5), ROCK2(1), RPS6KB1(1), SMAD5(1), SMAD6(1), SMAD9(2), SP1(2), THBS1(1), THBS3(1), THBS4(2), ZFYVE16(1), ZFYVE9(1)	4886845	45	12	45	32	24	2	5	8	6	0	0.952	1.000	1.000
414	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT2(2), BCL2(1), BCR(2), BLNK(1), BTK(3), CD22(2), CR2(3), ITPR1(1), ITPR2(1), ITPR3(1), NFATC1(1), NFATC2(3), PIK3CD(1), PLCG2(2), PPP3CA(1), PPP3CB(1), PPP3CC(1), PTPRC(2), RAF1(1), SOS1(1), SOS2(2), SYK(1), VAV1(3)	3621391	37	12	37	19	23	3	1	6	4	0	0.465	1.000	1.000
415	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT2(2), BCR(2), BTK(3), CDKN2A(2), GAB1(1), ITPR1(1), ITPR2(1), ITPR3(1), PLCG2(2), PREX1(1), PTEN(1), PTPRC(2), RPS6KA2(1), RPS6KB1(1), SAG(2), SYK(1), VAV1(3)	2695854	27	12	27	19	16	2	2	3	4	0	0.818	1.000	1.000
416	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	AKT2(2), BTK(3), CDKN2A(2), IARS(2), IGFBP1(1), PTEN(1), RPS6KA2(1), RPS6KB1(1), SOS1(1), SOS2(2)	1770974	16	12	16	10	8	1	1	3	3	0	0.842	1.000	1.000
417	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(2), AXIN1(2), CCND3(1), CTNNB1(1), DVL3(1), FZD1(1), FZD5(1), LDLR(3), MAPK9(3), PPP2R5C(1), PPP2R5E(2), PRKCA(2), PRKCG(1), PRKCH(3), PRKCI(1), PRKCQ(2), PRKCZ(1), SFRP4(1), TCF7(1), WNT10A(1), WNT10B(1), WNT16(1), WNT2(2), WNT3(1), WNT5A(1), WNT5B(1), WNT7A(3), WNT7B(2)	2904608	43	12	43	28	29	3	2	4	5	0	0.764	1.000	1.000
418	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BLNK(1), BTK(3), MAP2K1(1), MAPK8(1), NFATC1(1), NFATC2(3), NFATC4(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(2), RAF1(1), SOS1(1), SYK(1), SYT1(2), VAV1(3)	1858396	24	11	24	13	17	0	1	4	2	0	0.629	1.000	1.000
419	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ADH1A(2), ADH1B(4), ADH1C(3), ADH6(2), ADH7(1), AKR1C4(1), ALDH9A1(1), CEL(1), CYP7A1(1)	1146253	17	11	15	17	11	3	1	2	0	0	0.942	1.000	1.000
420	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(3), FCER1A(1), MAP2K1(1), MAP2K7(1), MAPK8(1), NFATC1(1), NFATC2(3), NFATC4(1), PAK2(1), PLA2G4A(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), RAF1(1), SOS1(1), SYK(1), SYT1(2), VAV1(3)	2105155	27	11	27	12	18	1	1	4	3	0	0.469	1.000	1.000
421	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPAT1(2), AGPAT4(1), CDS1(1), CHAT(1), DGKA(1), DGKB(3), DGKD(2), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), GNPAT(1), GPD1(1), PAFAH2(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(2), PLCG2(2), PPAP2C(1)	2452149	31	11	31	18	23	1	1	3	3	0	0.574	1.000	1.000
422	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(1), ALDOC(1), ENO2(1), GCK(5), GPI(2), HK2(1), HK3(3), LDHA(1), LDHAL6B(3), MDH1(1), PC(2), PCK1(3), PDHX(1), PGK2(3), PKLR(3), PKM2(1)	2105874	32	11	32	18	24	2	1	3	2	0	0.351	1.000	1.000
423	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACOX1(1), ACOX3(4), ACSL3(1), ACSL5(1), ACSL6(2), ADH1A(2), ADH1B(4), ADH1C(3), ADH5(1), ADH6(2), ADH7(1), ALDH7A1(2), ALDH9A1(1), CPT1A(3), CPT1C(1), CYP4A11(1), CYP4A22(3), EHHADH(2), HADHA(2), HSD17B4(1)	2430228	39	11	37	19	29	2	1	3	4	0	0.269	1.000	1.000
424	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP4A(1), ATP5F1(1), ATP5J(1), ATP5O(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1G3(1), COX15(1), COX8A(1), NDUFA4(1), NDUFB2(1), NDUFB6(1), NDUFS7(2)	2775521	20	11	20	10	12	1	2	4	1	0	0.517	1.000	1.000
425	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(2), ALG14(1), ALG3(1), C1GALT1(1), CHST1(1), CHST4(1), EXT2(1), EXTL3(1), FUT8(1), GALNT13(2), GALNT14(5), GALNT6(5), GALNTL2(1), GALNTL5(1), GCNT3(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(1), HS3ST3B1(1), HS6ST2(1), HS6ST3(2), MAN1A1(1), MAN1B1(1), MAN2A1(1), MGAT4A(2), MGAT5(1), MGAT5B(1), NDST1(2), NDST3(3), NDST4(4), RPN2(1), ST3GAL1(1), ST6GAL1(1), WBSCR17(1)	5370952	52	11	52	32	40	1	1	7	3	0	0.600	1.000	1.000
426	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(1), ACOX1(1), ACOX2(1), ACOX3(4), ACSL3(1), ACSL5(1), ACSL6(2), CD36(1), CPT1A(3), CPT1C(1), CYP4A11(1), CYP4A22(3), CYP7A1(1), CYP8B1(1), EHHADH(2), FABP1(2), GK(1), GK2(2), HMGCS2(2), ME1(1), PCK1(3), PPARG(2), RXRA(1), SLC27A1(1), SLC27A2(2), SLC27A6(1), SORBS1(1), UBC(1)	3242806	44	11	43	29	34	4	1	0	5	0	0.610	1.000	1.000
427	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP5A(1), INPPL1(1), PIK3C2B(1), PIK3C2G(4), PIK3CB(2), PLCB1(3), PLCB3(1), PLCB4(9), PLCD1(1), PLCG2(2)	2182894	25	11	24	15	13	0	2	5	5	0	0.823	1.000	1.000
428	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(1), DAXX(2), EGF(3), EGFR(3), ETS2(1), HOXA7(1), MAP2K1(1), MAP2K6(1), MAP2K7(1), MAP3K5(1), MAPK13(1), MAPK8(1), NFKB1(1), PRKCA(2), PRKCG(1), PRKCH(3), PRKCQ(2), RAF1(1), SP1(2), TRAF2(1)	2407035	30	11	30	18	20	0	3	6	1	0	0.724	1.000	1.000
429	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	AKT2(2), ARHGEF11(2), BTK(3), INPPL1(1), ITPR1(1), ITPR2(1), ITPR3(1), MYLK(2), MYLK2(3), PAK2(1), PAK3(1), PAK7(1), PIK3CD(1), PTEN(1), RHO(1), ROCK2(1), SAG(2)	3436763	25	11	25	13	18	0	0	4	3	0	0.607	1.000	1.000
430	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT2(2), BCR(2), BLNK(1), BTK(3), MAP2K1(1), NFKB1(1), NFKBIL1(1), PI3(2), PIK3CD(1), PLCG2(2), RAF1(1), SERPINA4(1), SOS1(1), SOS2(2), SYK(1), VAV1(3)	2601578	25	11	25	14	13	3	1	6	2	0	0.721	1.000	1.000
431	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(3), F2(1), F2RL1(2), MAP2K5(1), MAPK8(1), PLD2(1), PLD3(1), PTK2(2), RAF1(1), RASAL1(1), VAV1(3)	1350932	17	11	17	13	11	1	0	4	1	0	0.831	1.000	1.000
432	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CD3D(1), FYN(1), LCK(1), MAP2K1(1), MAPK8(1), NFATC1(1), NFATC2(3), NFATC4(1), NFKB1(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(2), RAF1(1), SOS1(1), SYT1(2), VAV1(3)	2315180	23	11	23	11	15	0	0	4	4	0	0.564	1.000	1.000
433	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), ARSD(1), ARSE(1), CYP11B1(1), CYP11B2(2), HSD11B1(1), HSD3B1(1), HSD3B2(1), STS(1), SULT2A1(1), UGT1A10(3), UGT1A3(1), UGT1A4(3), UGT1A5(1), UGT2B15(4), UGT2B4(2)	1337175	25	10	25	14	15	2	6	1	1	0	0.478	1.000	1.000
434	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(1), BAX(1), BCL2(1), BIRC3(1), BNIP3L(1), CASP8(1), DFFA(1), DFFB(1), FAS(1), FASLG(3), HELLS(2), IRF5(1), IRF6(3), NFKB1(1), PLEKHG5(2), PRF1(3), TNFRSF10B(1), TNFRSF21(1), TNFRSF25(1), TNFSF10(1), TP53(2), TRAF1(1), TRAF2(1)	2811663	32	10	32	22	18	3	3	2	6	0	0.877	1.000	1.000
435	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BAX(1), BCL2(1), CASP8(1), DAXX(2), DFFA(1), DFFB(1), FAS(1), FASLG(3), NFKB1(1), NTRK1(4), PTPN13(1), TRAF1(1), TRAF2(1), TRAF6(1)	2120905	21	10	21	18	9	0	3	3	6	0	0.982	1.000	1.000
436	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGTR2(1), CAMK2A(1), F2(1), FYN(1), GNA11(3), JAK2(1), MAP2K1(1), MAPK8(1), MAPT(1), MYLK(2), PRKCA(2), PTK2B(2), RAF1(1), SOS1(1), STAT3(3), SYT1(2)	2039643	24	10	23	15	12	0	2	8	2	0	0.806	1.000	1.000
437	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(4), ADH1C(3), ADH6(2), ADH7(1), AKR1A1(1), ALDH3B2(1), ALDH9A1(1), ALDOB(1), ALDOC(1), ENO2(1), GCK(5), GPI(2), HK2(1), HK3(3), LDHA(1), PKLR(3), PKM2(1)	2414380	34	10	32	25	27	2	2	2	1	0	0.704	1.000	1.000
438	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(4), ADH1C(3), ADH6(2), ADH7(1), AKR1A1(1), ALDH3B2(1), ALDH9A1(1), ALDOB(1), ALDOC(1), ENO2(1), GCK(5), GPI(2), HK2(1), HK3(3), LDHA(1), PKLR(3), PKM2(1)	2414380	34	10	32	25	27	2	2	2	1	0	0.704	1.000	1.000
439	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX12B(1), ALOX15(2), ALOX15B(2), ALOX5(2), CBR3(1), CYP2B6(3), CYP2C18(2), CYP2C19(2), CYP2C8(2), CYP2C9(3), CYP2E1(2), CYP4A11(1), CYP4A22(3), CYP4F2(1), EPHX2(1), GPX1(1), GPX5(2), GPX6(1), PLA2G2A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PTGES2(1), PTGS2(2)	1904026	42	10	42	23	32	3	1	1	5	0	0.272	1.000	1.000
440	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ARRB2(1), CAMK2A(1), CLCA2(2), CLCA4(1), CNGA3(4), CNGB1(2), GUCA1A(1), PDC(1), PDE1C(4), PRKACG(2), PRKG1(1), PRKG2(3), PRKX(1)	1469565	24	10	23	17	19	1	1	3	0	0	0.702	1.000	1.000
441	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(2), ACSL3(1), ACSL5(1), ACSL6(2), AKT2(2), CAMKK1(1), CD36(1), CPT1A(3), CPT1C(1), G6PC2(1), IRS1(1), IRS4(2), JAK1(1), JAK2(1), JAK3(1), LEPR(3), MAPK8(1), MAPK9(3), NFKB1(1), PCK1(3), PPARGC1A(2), PRKAA2(1), PRKAG3(1), PRKCQ(2), PTPN11(1), RXRA(1), SLC2A4(1), STAT3(3), TRAF2(1)	4096127	45	10	45	34	25	5	3	6	6	0	0.949	1.000	1.000
442	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1G3(1), EGFR(3), F11R(1), JAM2(2), MAPK13(1), MAPK8(1), MAPK9(3), NFKB1(1), PLCG2(2), PTPN11(1), PTPRZ1(2)	3450921	25	10	25	20	18	1	1	4	1	0	0.940	1.000	1.000
443	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	CRK(1), CRKL(1), GAB1(1), HGF(3), MAP2K1(1), MAPK8(1), PTEN(1), PTK2(2), PTK2B(2), PTPN11(1), PXN(1), RAF1(1), SOS1(1), STAT3(3)	2133656	20	10	20	12	9	0	1	8	2	0	0.908	1.000	1.000
444	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(2), CREB5(2), GNAQ(1), MAP2K7(1), MAPK8(1), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(2), MAPK9(3)	1391970	17	10	17	13	7	1	0	6	3	0	0.954	1.000	1.000
445	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	APC(2), GNAQ(1), ITPR1(1), ITPR2(1), ITPR3(1), KCNJ5(1), RHO(1), RYR1(11)	2209761	19	10	19	14	12	0	1	3	3	0	0.758	1.000	1.000
446	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(1), BAX(1), BCL2(1), BIRC3(1), CASP8(1), FAS(1), FASLG(3), NFKB1(1), PARP1(2), PRF1(3), TNFSF10(1), TP53(2), TRAF1(1), TRAF2(1)	1831340	20	9	20	14	10	1	2	0	7	0	0.906	1.000	1.000
447	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), IDH1(3), MDH1(1), PC(2), PCK1(3), SUCLG2(1)	1027563	11	9	10	7	9	1	0	1	0	0	0.637	1.000	1.000
448	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1QB(1), C1R(1), C1S(3), C2(3), C3(4), C6(1), C7(5), C8A(3), MASP2(2), MBL2(1)	1031562	25	9	25	14	18	1	2	3	1	0	0.609	1.000	1.000
449	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(4), AGXT2(2), AOC2(1), BHMT(2), CHDH(1), DAO(1), GARS(1), PLCG2(2), SARDH(2), SARS(2), SHMT2(1)	2075387	19	9	19	14	14	1	1	3	0	0	0.745	1.000	1.000
450	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(2), GNAQ(1), GNAS(3), MAP2K1(1), NFATC1(1), NFATC2(3), NFATC4(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(2), PRKAR1B(1), PRKCA(2), RAF1(1), SYT1(2)	1709861	23	9	23	18	18	0	0	3	2	0	0.889	1.000	1.000
451	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(1), UGT1A10(3), UGT1A3(1), UGT1A4(3), UGT1A5(1), UGT2B10(1), UGT2B11(1), UGT2B15(4), UGT2B28(2), UGT2B4(2), UGT2B7(1)	1322481	20	9	20	10	12	0	5	1	2	0	0.477	1.000	1.000
452	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(4), AGXT2(2), AOC2(1), BHMT(2), CHDH(1), DAO(1), GARS(1), GNMT(1), PHGDH(2), PIPOX(1), SARDH(2), SARS(2), SARS2(1), SDS(1), SHMT2(1), TARS2(1)	2113845	24	9	24	13	16	1	1	3	3	0	0.449	1.000	1.000
453	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA1(1), ALDH7A1(2), ALDH9A1(1), AOX1(3), AUH(1), BCAT1(1), BCAT2(1), BCKDHB(1), EHHADH(2), HADHA(2), HIBADH(1), HMGCS2(2), HSD17B4(1), IVD(1), OXCT1(1), OXCT2(1), PCCB(1)	2128434	23	9	23	12	17	1	1	3	1	0	0.573	1.000	1.000
454	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ASS1(1), DAO(1), NOS1(3), NOS3(3), P4HA3(1), RARS(2), RARS2(2)	1760860	14	9	14	13	10	2	0	0	2	0	0.868	1.000	1.000
455	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(2), ALOX5(2), CYP1A2(1), CYP2C18(2), CYP2C19(2), CYP2C8(2), CYP2C9(3), CYP2E1(2), CYP3A4(3), CYP3A5(1), PLA2G2A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2)	1170131	27	9	27	16	22	1	0	0	4	0	0.428	1.000	1.000
456	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(4), ADH1C(3), ADH5(1), ADH6(2), ADH7(1), ALDH7A1(2), ALDH9A1(1)	652357	16	9	14	11	11	1	1	3	0	0	0.719	1.000	1.000
457	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT2(2), EIF4EBP1(1), IGF1(1), PIK3CB(2), PIK3CD(1), PIK3R2(1), PRKAA2(1), RHEB(1), RICTOR(2), RPS6KA2(1), RPS6KA6(2), RPS6KB1(1), TSC1(1), TSC2(1), ULK1(1)	2591895	19	9	19	13	9	4	2	1	3	0	0.884	1.000	1.000
458	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IL1R1(2), IL1RAP(1), IL1RN(1), IL6(1), IRAK2(2), MAP2K6(1), MAPK8(1), NFKB1(1), TRAF6(1)	1446521	11	9	11	10	6	0	1	2	2	0	0.914	1.000	1.000
459	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A2(2), COL4A3(4), COL4A4(10), COL4A5(3), COL4A6(2), F11(1), F12(1), F2(1), F2R(1), F8(2), F9(1), FGA(3), FGB(1), KLKB1(1), PROC(1), PROS1(1), SERPINC1(1), SERPING1(4)	2181265	40	9	40	22	33	1	1	4	1	0	0.969	1.000	1.000
460	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(4), C6(1), C7(5), IL6(1), ITGA4(1), ITGAL(2), SELP(1), SELPLG(1), VCAM1(2)	1197579	18	9	18	12	10	1	2	2	3	0	0.820	1.000	1.000
461	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	CAMK4(1), CREBBP(3), EDN1(2), F2(1), FKBP1A(1), HAND2(1), IGF1(1), MAP2K1(1), MAPK8(1), MYH2(9), NFATC1(1), NFATC2(3), NFATC4(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(2), PRKAR1B(1), RAF1(1), RPS6KB1(1), SYT1(2)	2506510	36	9	36	19	27	2	2	3	2	0	0.437	1.000	1.000
462	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	GRIN1(1), GRIN2A(7), GRIN2B(3), NOS1(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(2), PRKAR1B(1), PRKCA(2), SYT1(2)	1251222	24	9	24	17	17	3	1	1	2	0	0.606	1.000	1.000
463	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(3), AR(1), ESR1(1), HNF4A(1), NR1D2(1), NR1I2(1), NR1I3(1), NR2E1(1), NR5A2(3), PGR(1), PPARG(2), ROR1(2), RORC(2), RXRA(1)	2054776	21	9	21	12	15	1	1	4	0	0	0.559	1.000	1.000
464	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(1), CD36(1), CREBBP(3), EHHADH(2), EP300(2), FABP1(2), HSD17B4(1), ME1(1), NCOA1(1), NCOR1(4), NRIP1(1), PRKACG(2), PRKAR1B(1), PRKCA(2), PTGS2(2), RB1(1), RXRA(1), SP1(2), STAT5B(1)	3127326	31	9	30	18	20	3	3	2	3	0	0.630	1.000	1.000
465	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX15(2), ALOX5(2), CBR3(1), CYP4F2(1), LPO(3), MPO(3), PLA2G2A(1), PLA2G4A(3), PLA2G6(2), PRDX1(2), PTGES2(1), PTGS2(2), TPO(3)	1378369	26	9	26	17	19	1	0	2	4	0	0.573	1.000	1.000
466	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(5), CDR1(1), IL6ST(1), RPL14(1), RPL22(1), RPL27A(1), RPL5(1), RPL7(1), RPLP0(1), RPS2(1), RPS29(1), RPS3A(1), RPS6KA2(1), RPS6KA6(2), RPS6KB1(1), RPSA(1), UBC(1)	2551012	22	9	22	17	13	2	2	2	3	0	0.917	1.000	1.000
467	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT2(2), ARHGEF11(2), BCL2(1), GNA13(1), LPA(3), MAP3K5(1), MAPK8(1), NFKB1(1), NFKBIL1(1), PI3(2), PIK3CB(2), PLD2(1), PLD3(1), PTK2(2), ROCK2(1), SERPINA4(1), TBXA2R(1)	2405202	24	9	24	14	14	1	0	5	4	0	0.776	1.000	1.000
468	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(1), CD3D(1), FBXW7(1), GRAP2(1), ITK(3), LCK(1), NFKB1(1), NFKBIL1(1), PAK2(1), PAK3(1), PAK7(1), PTPRC(2), RAF1(1), RASGRP1(1), RASGRP3(2), SOS1(1), SOS2(2), VAV1(3)	2709118	25	9	25	16	15	0	1	5	4	0	0.805	1.000	1.000
469	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT2(2), APC(2), AXIN1(2), CTNNB1(1), DKK1(1), DKK2(2), DKK3(2), LRP1(1), SENP2(1), WIF1(1)	1958785	15	9	14	16	8	2	1	2	2	0	0.986	1.000	1.000
470	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(4), ADH1C(3), ADH6(2), ADH7(1)	277259	12	8	10	7	9	0	1	2	0	0	0.641	1.000	1.000
471	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(2), AXIN1(2), BMP10(2), BMP5(1), BMPR2(1), CTNNB1(1), FZD1(1), NPPB(1), RFC1(1), TGFBR3(1)	1765543	13	8	13	12	8	1	0	1	3	0	0.974	1.000	1.000
472	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(4), ALDH4A1(1), ALDH9A1(1), AOC2(1), DAO(1), NOS1(3), NOS3(3), P4HA3(1), P4HB(1), RARS(2)	2163015	18	8	18	19	12	4	0	0	2	0	0.940	1.000	1.000
473	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABP1(4), ALDH9A1(1), AOC2(1), CNDP1(2), DPYD(4), EHHADH(2), GAD2(1), HADHA(2), MLYCD(1), SDS(1)	1432616	19	8	19	12	15	1	1	1	1	0	0.633	1.000	1.000
474	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), MAP2K1(1), NFKB1(1), PLCB1(3), PRKCA(2), RAF1(1)	768727	10	8	10	7	7	0	0	3	0	0	0.804	1.000	1.000
475	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1QB(1), C1R(1), C1S(3), C2(3), C3(4), C6(1), C7(5), C8A(3)	843061	22	8	22	10	16	1	2	3	0	0	0.401	1.000	1.000
476	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1QB(1), C1R(1), C1S(3), C2(3), C3(4), C6(1), C7(5), C8A(3), C8B(1)	1005036	23	8	23	13	17	1	2	3	0	0	0.603	1.000	1.000
477	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGF(3), EGFR(3), JAK1(1), MAP2K1(1), MAPK8(1), PRKCA(2), RAF1(1), SOS1(1), STAT3(3)	1833275	16	8	16	10	9	0	1	4	2	0	0.828	1.000	1.000
478	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	APC(2), AXIN1(2), CD14(1), CTNNB1(1), FZD1(1), GJA1(1), LBP(1), NFKB1(1), TLR4(1)	1480563	11	8	11	11	5	2	1	1	2	0	0.975	1.000	1.000
479	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), ALDOB(1), ALDOC(1), GMDS(2), GMPPB(1), HK2(1), HK3(3), PFKFB2(1), PFKFB3(1), PFKFB4(2)	1816766	14	8	14	12	12	1	0	1	0	0	0.766	1.000	1.000
480	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ADC(1), ALDH4A1(1), ALDH5A1(2), CAD(2), GAD2(1), GFPT1(1), GFPT2(1), GLS2(2), GPT(1), GSS(1), NADSYN1(2), QARS(2)	1951314	17	8	17	10	11	1	2	3	0	0	0.619	1.000	1.000
481	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABP1(4), ALDH7A1(2), ALDH9A1(1), AOC2(1), CNDP1(2), DPYD(4), EHHADH(2), GAD2(1), HADHA(2), MLYCD(1)	1333507	20	8	20	12	17	1	1	1	0	0	0.565	1.000	1.000
482	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(1), ARSE(1), DEGS1(1), ENPP7(4), GAL3ST1(3), GBA(2), GLA(1), GLB1(2), LCT(3), NEU1(1), NEU2(3), NEU3(1), PPAP2C(1), SGMS1(2), SGMS2(1), SGPP2(2), UGT8(1)	1741556	30	8	30	15	20	3	1	4	2	0	0.338	1.000	1.000
483	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(1), ALDOC(1), GPT(1), MDH1(1), ME1(1), PGK2(3), PKLR(3), PKM2(1), TKTL2(3)	1001691	15	8	15	11	11	1	0	2	1	0	0.684	1.000	1.000
484	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPP(1), ALPPL2(2), ASCC3(2), ATP13A2(1), DDX23(1), DDX4(2), DDX47(1), DDX56(2), EP400(1), ERCC2(1), IFIH1(1), MOV10L1(8), NUDT8(1), QDPR(1), RAD54B(2), SETX(2), SMARCA2(2), SPR(1)	3067308	33	8	33	16	24	3	0	1	5	0	0.358	1.000	1.000
485	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ADCY9(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1C2(1), ATP6V1G3(1), ERO1L(1), GNAS(3), PLCG2(2), PRKCA(2), SEC61A2(1), TRIM23(1)	1835870	20	8	20	16	14	1	2	2	1	0	0.808	1.000	1.000
486	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(1), ADRA1D(1), CHRM1(1), CHRM2(1), CHRM3(2), CHRM4(1), CHRM5(1), DRD2(2), DRD5(3), HRH1(1), HTR1A(1), HTR1E(1), HTR2A(1), HTR5A(1)	1234306	18	8	18	16	11	3	1	1	2	0	0.551	1.000	1.000
487	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP5O(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1G3(1), ATP7A(3), ATP7B(2), COX8A(1), NDUFA4(1), NDUFB2(1), NDUFB6(1)	1903848	16	8	16	11	9	0	4	3	0	0	0.770	1.000	1.000
488	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(2), AXIN1(2), CREBBP(3), CTNNB1(1), EP300(2), FZD1(1), TRRAP(5)	1638061	16	8	16	14	7	2	1	3	3	0	0.971	1.000	1.000
489	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(2), CANT1(1), CTPS2(2), DPYD(4), ENTPD1(2), NT5E(1), POLE(2), POLG(1), POLL(1), POLQ(2), POLR1B(1), POLR2A(2), UNG(1)	2834517	22	8	22	13	17	1	0	2	2	0	0.638	1.000	1.000
490	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	BCR(2), BLNK(1), MAP2K1(1), MAPK8IP3(2), PAPPA(4), SOS1(1), SYK(1), VAV1(3)	1531516	15	8	15	12	8	2	1	4	0	0	0.905	1.000	1.000
491	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), ITPR1(1), ITPR2(1), ITPR3(1), PDE6A(1), PDE6B(3), PDE6C(1), SLC6A13(2), TF(1)	1748580	12	8	12	9	9	1	1	1	0	0	0.685	1.000	1.000
492	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CCR5(2), CXCR4(1), GNAQ(1), MAPK8(1), PRKCA(2), PTK2B(2), SYT1(2)	685715	11	7	11	9	8	1	0	2	0	0	0.812	1.000	1.000
493	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CSNK1D(1), DRD2(2), GRM1(2), PLCB1(3), PPP3CA(1), PRKACG(2), PRKAR1B(1)	780850	12	7	12	15	9	0	1	1	1	0	0.989	1.000	1.000
494	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOB(1), ALDOC(1), GCK(5), GMDS(2), GMPPB(1), HK2(1), HK3(3), PFKFB3(1), PFKFB4(2)	1176607	18	7	18	12	16	1	0	1	0	0	0.483	1.000	1.000
495	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), GAA(1), GCK(5), GLA(1), GLB1(2), HK2(1), HK3(3), LCT(3), MGAM(12)	1593365	29	7	29	16	24	3	0	2	0	0	0.360	1.000	1.000
496	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(2), G6PD(1), GPX1(1), GPX5(2), GSS(1), GSTA1(1), IDH1(3), PGD(1)	894851	12	7	11	11	9	2	0	1	0	0	0.824	1.000	1.000
497	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSD(1), ARSE(1), GAL3ST1(3), GBA(2), GLA(1), GLB1(2), LCT(3), NEU1(1), NEU2(3), NEU3(1), PPAP2C(1)	1180356	19	7	19	13	13	3	1	2	0	0	0.737	1.000	1.000
498	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	ADSL(2), ADSSL1(1), AGXT2(2), ASRGL1(1), ASS1(1), CAD(2), CRAT(1), GAD2(1), GPT(1), NARS(1), NARS2(2), PC(2)	1878949	17	7	17	11	13	1	1	2	0	0	0.653	1.000	1.000
499	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	ALDH7A1(2), ALDH9A1(1), EHHADH(2), EHMT1(2), EHMT2(1), HADHA(2), HSD17B4(1), NSD1(1), OGDH(2), OGDHL(4), PIPOX(1), PLOD1(1), SETD1A(2), SHMT2(1)	2856201	23	7	23	12	20	3	0	0	0	0	0.372	1.000	1.000
500	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(2), G6PD(1), GPX1(1), GPX5(2), GPX6(1), GSS(1), GSTA1(1), GSTA5(1), IDH1(3)	1079288	13	7	12	14	10	2	0	1	0	0	0.916	1.000	1.000
501	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	C1GALT1(1), GALNT13(2), GALNT14(5), GALNT6(5), GALNTL2(1), GALNTL5(1), GCNT3(1), ST3GAL1(1), WBSCR17(1)	1591479	18	7	18	12	16	0	0	1	1	0	0.741	1.000	1.000
502	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT4(1), PAFAH2(1), PLA2G2A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLD2(1), PPAP2C(1)	1151540	13	7	13	11	8	1	0	1	3	0	0.910	1.000	1.000
503	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACB(2), ACSS2(2), ALDH7A1(2), ALDH9A1(1), EHHADH(2), HADHA(2), LDHA(1), LDHAL6B(3), MLYCD(1), PCCB(1), SUCLG2(1)	1967120	18	7	18	13	16	1	0	0	1	0	0.724	1.000	1.000
504	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), ACSM1(1), ALDH5A1(2), ALDH7A1(2), ALDH9A1(1), BDH1(1), DDHD1(3), EHHADH(2), GAD2(1), HADHA(2), HMGCS2(2), HSD17B4(1), OXCT1(1), OXCT2(1), PLA1A(2), PPME1(1)	2008946	24	7	24	14	18	2	2	0	2	0	0.513	1.000	1.000
505	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B4GALNT1(1), FUT1(2), FUT2(1), FUT3(1), FUT9(2), PIGB(1), PIGU(2), ST3GAL1(1), ST6GALNAC3(2), ST6GALNAC5(2)	2388175	15	7	15	14	8	2	0	4	1	0	0.949	1.000	1.000
506	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	ALDH9A1(1), EHHADH(2), EHMT1(2), EHMT2(1), HADHA(2), PLOD1(1), SDS(1), SHMT2(1)	1812632	11	7	11	11	7	3	0	0	1	0	0.898	1.000	1.000
507	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(2), CCR5(2), CXCR4(1), IL12A(1), IL12RB1(2), IL12RB2(1), IL18R1(1)	988522	10	7	10	8	7	2	0	1	0	0	0.750	1.000	1.000
508	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PLCB1(3), PRKCA(2), VAV1(3)	634465	8	7	8	5	7	0	0	1	0	0	0.738	1.000	1.000
509	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP5(1), ARHGAP6(1), ARHGEF11(2), ARHGEF5(3), ARPC1B(3), MYLK(2), PIP5K1A(2), PIP5K1B(1), TLN1(1)	2223287	16	7	16	10	11	0	1	3	1	0	0.692	1.000	1.000
510	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), FLNA(1), FLNC(4), FSCN1(1), FSCN3(1), MYH2(9), MYLK(2), MYLK2(3), PAK2(1), PAK3(1), PAK7(1), RHO(1), ROCK2(1)	2351178	27	7	27	17	21	2	2	2	0	0	0.553	1.000	1.000
511	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	CREB5(2), MAP2K1(1), MKNK2(1), MOS(2), NFKB1(1), RPS6KA2(1), SOS1(1), SOS2(2)	1445702	11	7	11	9	7	1	0	3	0	0	0.933	1.000	1.000
512	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), MAP2K6(1), MAPK8(1), NFKB1(1), TLR2(1), TLR4(1), TLR7(1), TLR9(1), TRAF6(1)	1778489	9	7	9	9	6	1	1	1	0	0	0.916	1.000	1.000
513	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	GNAQ(1), NFATC1(1), NFATC2(3), NFKB1(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(2), PRKAR1B(1), SYT1(2), VIPR2(1)	1363818	15	7	15	16	11	0	0	2	2	0	0.972	1.000	1.000
514	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A2(2), COL4A3(4), COL4A4(10), COL4A5(3), COL4A6(2), P4HB(1), SLC23A2(2), SLC2A3(1)	1221688	25	7	25	15	22	1	0	2	0	0	0.985	1.000	1.000
515	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(4), GABBR1(1), GRM1(2), GRM3(4), GRM4(1), GRM5(1), GRM7(3), GRM8(7)	1020648	23	6	23	23	16	4	0	1	2	0	0.868	1.000	1.000
516	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(4), ALDH3B2(1), ALDH9A1(1), AOC2(1), CNDP1(2), DDC(2), HARS(1), HDC(2), HNMT(1), PRPS2(1)	1197103	16	6	16	10	11	1	0	2	2	0	0.524	1.000	1.000
517	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(4), ADC(1), ALDH7A1(2), ALDH9A1(1), AOC2(1), ASS1(1)	1431767	10	6	10	9	8	1	0	1	0	0	0.826	1.000	1.000
518	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG14(1), ALG3(1), DOLPP1(1), FUT8(1), MAN1A1(1), MAN1B1(1), MAN2A1(1), MGAT4A(2), MGAT5(1), MGAT5B(1), RPN2(1), ST6GAL1(1)	2080912	13	6	13	14	8	1	0	3	1	0	0.967	1.000	1.000
519	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(2), CD3D(1), ETV5(2), IL12A(1), IL12RB1(2), IL12RB2(1), IL18R1(1), JAK2(1), MAP2K6(1), MAPK8(1), STAT4(2)	917133	15	6	15	10	10	1	0	3	1	0	0.798	1.000	1.000
520	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	MDH1(1), OGDH(2), PC(2), PDHX(1), PDK4(1), PDP2(1), SUCLG2(1)	1407851	9	6	9	8	7	1	0	1	0	0	0.876	1.000	1.000
521	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPN2(2), CAPNS1(1), EGF(3), EGFR(3), MYLK(2), PRKACG(2), PRKAR1B(1), PTK2(2), PXN(1), TLN1(1)	1601185	18	6	18	13	14	0	0	1	3	0	0.740	1.000	1.000
522	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(1), GNA13(1), GNAQ(1), MYLK(2), PLCB1(3), PRKCA(2)	1026313	10	6	10	8	7	0	0	3	0	0	0.930	1.000	1.000
523	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	19	KLRC2(1), KLRD1(1), MAP2K1(1), PTK2B(2), SYK(1), VAV1(3)	891595	9	6	9	5	7	0	1	1	0	0	0.644	1.000	1.000
524	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(2), F2(1), F2R(1), GNA13(1), GNAQ(1), PLCB1(3), PRKCA(2), PTK2B(2)	1268531	13	6	13	11	10	0	0	3	0	0	0.930	1.000	1.000
525	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ADH5(1), AKR1B1(1), ALDH9A1(1), LDHA(1), MDH1(1), ME1(1), PC(2), PCK1(3), PKLR(3), PKM2(1)	1825417	15	6	15	14	10	3	0	1	1	0	0.915	1.000	1.000
526	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CD44(2), FCGR3A(1), IL6R(1), TNFRSF8(3)	634393	9	6	9	12	3	0	1	2	3	0	0.995	1.000	1.000
527	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT2(2), IARS(2), IL2RG(1), JAK1(1), JAK2(1), JAK3(1), PI3(2), RPS6KB1(1), SERPINA4(1), SOS1(1), SOS2(2), STAT6(1)	1812862	16	6	16	12	8	2	1	4	1	0	0.926	1.000	1.000
528	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(2), CD3D(1), CREBBP(3), GNAS(3), HLA-DRA(2), LCK(1), PRKACG(2), PRKAR1B(1), PTPRC(2)	1110203	17	5	17	12	15	0	1	0	1	0	0.711	1.000	1.000
529	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1G3(1)	747544	7	5	7	6	4	0	1	2	0	0	0.835	1.000	1.000
530	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(2), CAMK2A(1), GNAS(3), PRKACG(2), PRKAR1B(1), PRKCA(2), SOS1(1)	1396139	12	5	12	12	10	0	1	1	0	0	0.944	1.000	1.000
531	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(2), CD3D(1), CREBBP(3), GNAS(3), HLA-DRA(2), LCK(1), PRKACG(2), PRKAR1B(1), PTPRC(2)	1110203	17	5	17	12	15	0	1	0	1	0	0.711	1.000	1.000
532	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(2), CD2(1), CD33(1), CD5(1), IL12A(1), ITGAX(1), TLR2(1), TLR4(1), TLR7(1), TLR9(1)	914038	11	5	11	11	8	0	1	1	1	0	0.801	1.000	1.000
533	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15(2), ALOX15B(2), ALOX5(2), PLA2G2A(1), PLA2G6(2), PTGS2(2)	737577	11	5	11	10	10	0	0	0	1	0	0.718	1.000	1.000
534	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1G3(1)	747544	7	5	7	6	4	0	1	2	0	0	0.835	1.000	1.000
535	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(1), CALCR(2), CD97(1), CRHR1(1), ELTD1(3), EMR1(5), GHRHR(1), GLP1R(2), LPHN1(1), LPHN2(3), LPHN3(1), VIPR2(1)	1284588	22	5	22	23	14	1	1	2	4	0	0.953	1.000	1.000
536	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(1), GLB1(2), HEXA(1), LCT(3), ST3GAL1(1), ST6GALNAC3(2), ST6GALNAC5(2)	817413	12	5	12	9	7	2	0	3	0	0	0.820	1.000	1.000
537	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACB(2), ACOT12(1), ACSS2(2), AKR1B1(1), ALDH7A1(2), ALDH9A1(1), LDHA(1), LDHAL6B(3), MDH1(1), ME1(1), PC(2), PCK1(3), PKLR(3), PKM2(1)	2313584	24	5	24	18	19	3	0	0	2	0	0.726	1.000	1.000
538	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(1), CREBBP(3), EP300(2), FYN(1), IL2RG(1), IL7R(3), JAK1(1), JAK3(1), LCK(1), PTK2B(2), STAT5B(1)	1377788	17	5	17	10	14	1	1	0	1	0	0.671	1.000	1.000
539	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	CPT1A(3), LEPR(3), PRKAA2(1)	723462	7	5	7	6	6	0	0	1	0	0	0.889	1.000	1.000
540	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IL1R1(2), NFKB1(1), TLR4(1), TRAF6(1)	1169198	5	5	5	9	3	0	1	1	0	0	0.994	1.000	1.000
541	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(3), EP300(2), MAP2K6(1), NFKB1(1), TLR2(1)	1463337	8	5	8	9	7	0	1	0	0	0	0.955	1.000	1.000
542	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1G3(1), FDXR(1)	794886	8	5	8	7	5	0	1	2	0	0	0.834	1.000	1.000
543	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(2), GNAS(3), PLCE1(3), PRKACG(2), PRKAR1B(1)	714185	11	5	11	9	11	0	0	0	0	0	0.793	1.000	1.000
544	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), IDH1(3), MDH1(1)	444908	5	5	4	4	4	0	0	1	0	0	0.803	1.000	1.000
545	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(3), EP300(2), HDAC3(1), NFKB1(1), TRAF6(1)	1103552	8	5	8	6	7	0	1	0	0	0	0.803	1.000	1.000
546	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	MTNR1B(1), PTGDR(3), PTGER2(1), PTGFR(4), PTGIR(1), TBXA2R(1)	552506	11	5	11	10	9	1	1	0	0	0	0.651	1.000	1.000
547	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1G3(1)	747544	7	5	7	6	4	0	1	2	0	0	0.835	1.000	1.000
548	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(3), PRKACG(2), PRKAR1B(1), PRKCA(2)	465924	8	4	8	7	8	0	0	0	0	0	0.860	1.000	1.000
549	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(3), EP300(2), NCOA3(1), PRKACG(2), PRKAR1B(1), RXRA(1)	1025246	10	4	10	9	7	1	1	1	0	0	0.929	1.000	1.000
550	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(2), CFTR(4), GNAS(3), PRKACG(2), PRKAR1B(1), SLC9A3R1(1)	629254	13	4	13	8	13	0	0	0	0	0	0.558	1.000	1.000
551	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(2), FHL5(1), FSHR(2), GNAS(3)	462309	8	4	8	5	8	0	0	0	0	0	0.657	1.000	1.000
552	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	OPRK1(3), POLR2A(2), PRKACG(2), PRKAR1B(1)	633502	8	4	8	9	7	1	0	0	0	0	0.900	1.000	1.000
553	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(1), F2R(1), F7(1), FGA(3), FGB(1), PROC(1), PROS1(1), SERPINC1(1)	804594	10	4	10	9	7	2	0	1	0	0	0.937	1.000	1.000
554	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	BDH1(1), HMGCS2(2), OXCT1(1), OXCT2(1)	352183	5	4	5	4	5	0	0	0	0	0	0.818	1.000	1.000
555	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	PAPSS1(1), PAPSS2(3), SULT2A1(1), SULT2B1(1), SUOX(2)	449011	8	4	8	5	7	1	0	0	0	0	0.568	1.000	1.000
556	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	GALNS(1), GBA(2), GLB1(2), HEXA(1), HPSE(1), HPSE2(1), IDUA(1), LCT(3), NAGLU(1), NEU1(1), NEU2(3), NEU3(1), SPAM1(2)	1677810	20	4	20	10	13	2	1	1	3	0	0.402	1.000	1.000
557	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), FUT8(1), MAN1A1(1), MAN1B1(1), MGAT4A(2), MGAT5(1), RPN2(1), ST6GAL1(1)	988463	9	4	9	8	7	1	0	1	0	0	0.816	1.000	1.000
558	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	IFNAR2(1), MAPK8(1), NFKB1(1), TRAF6(1)	545346	4	4	4	6	3	0	0	1	0	0	0.986	1.000	1.000
559	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	HDAC3(1), NCOA1(1), NCOA3(1), POLR2A(2), RXRA(1)	1225923	6	4	6	5	4	1	0	1	0	0	0.851	1.000	1.000
560	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(2), GPT(1), LDHA(1), NCL(1)	447440	5	4	5	4	5	0	0	0	0	0	0.734	1.000	1.000
561	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(2), PRKACG(2)	878604	4	3	4	7	4	0	0	0	0	0	0.990	1.000	1.000
562	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK2A(1), CAMK4(1), CAMKK1(1), SYT1(2)	572460	5	3	5	8	3	0	1	1	0	0	0.976	1.000	1.000
563	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST2(1), HS3ST3A1(1), HS3ST3B1(1)	315333	4	3	4	5	3	0	0	1	0	0	0.917	1.000	1.000
564	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(2), GNAS(3), PRKAA2(1), PRKACG(2), PRKAR1B(1)	751530	9	3	9	9	9	0	0	0	0	0	0.913	1.000	1.000
565	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	LCT(3), PYGM(1)	653136	4	3	4	4	3	1	0	0	0	0	0.781	1.000	1.000
566	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1), GRIA2(1), JUND(1)	177103	3	3	3	6	2	0	1	0	0	0	0.982	1.000	1.000
567	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST2(1), HS3ST3A1(1), HS3ST3B1(1)	315333	4	3	4	5	3	0	0	1	0	0	0.917	1.000	1.000
568	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACB(2), FASN(2), OLAH(1)	782087	5	3	5	7	4	0	0	1	0	0	0.945	1.000	1.000
569	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	GLB1(2), HEXA(1), LCT(3), NEU1(1), NEU2(3), NEU3(1)	1000692	11	3	11	8	7	2	1	1	0	0	0.757	1.000	1.000
570	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	HLA-DRA(2), IL5RA(1), IL6(1)	263806	4	3	4	4	3	0	1	0	0	0	0.799	1.000	1.000
571	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	HLA-DRA(2), IL12A(1), IL6(1)	648302	4	3	4	5	2	0	1	1	0	0	0.910	1.000	1.000
572	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	PRKCA(2), PTK2B(2)	337462	4	3	4	5	4	0	0	0	0	0	0.856	1.000	1.000
573	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(2), GNAS(3), MYT1(2), PRKACG(2), PRKAR1B(1)	1007281	10	3	10	13	10	0	0	0	0	0	0.959	1.000	1.000
574	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	GLB1(2), HEXA(1), LCT(3), NEU1(1), NEU2(3), NEU3(1)	813238	11	3	11	8	7	2	1	1	0	0	0.783	1.000	1.000
575	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	SNCAIP(5)	316142	5	3	5	5	5	0	0	0	0	0	0.884	1.000	1.000
576	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	MAP2K1(1), NFKB1(1), RAF1(1)	911491	3	3	3	4	1	0	0	2	0	0	0.980	1.000	1.000
577	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), PPARG(2), RXRA(1)	288484	4	3	4	5	3	1	0	0	0	0	0.894	1.000	1.000
578	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	GHR(1), NFKB1(1)	686780	2	2	2	3	1	0	0	1	0	0	0.967	1.000	1.000
579	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	IKBKAP(1), NFKB1(1), TRAF6(1)	883300	3	2	3	5	2	0	0	1	0	0	0.981	1.000	1.000
580	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	MYT1(2)	676263	2	2	2	4	2	0	0	0	0	0	0.979	1.000	1.000
581	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL12A(1), IL6(1)	487624	2	2	2	5	0	0	1	1	0	0	0.989	1.000	1.000
582	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH7A1(2), ALDH9A1(1)	418868	3	2	3	5	2	1	0	0	0	0	0.945	1.000	1.000
583	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	CSAD(1), GAD2(1)	277421	2	2	2	3	1	0	1	0	0	0	0.927	1.000	1.000
584	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS2(2)	225646	2	2	2	4	2	0	0	0	0	0	0.970	1.000	1.000
585	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	DSE(3)	650159	3	2	3	7	3	0	0	0	0	0	0.978	1.000	1.000
586	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	FUT1(2), FUT2(1), FUT3(1)	357388	4	2	4	5	3	1	0	0	0	0	0.887	1.000	1.000
587	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	APOBEC1(1), APOBEC3A(1)	369383	2	2	2	3	2	0	0	0	0	0	0.925	1.000	1.000
588	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR2(1), JAK1(1)	533614	2	2	2	4	2	0	0	0	0	0	0.978	1.000	1.000
589	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	MDH1(1), OGDH(2)	470013	3	2	3	4	3	0	0	0	0	0	0.903	1.000	1.000
590	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	HDAC9(3), MEF2B(1)	356226	4	2	4	4	2	2	0	0	0	0	0.857	1.000	1.000
591	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ESR1(1), GREB1(1)	521063	2	2	2	6	1	0	1	0	0	0	0.995	1.000	1.000
592	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(1), NOTCH1(1)	456274	2	2	2	5	1	0	1	0	0	0	0.986	1.000	1.000
593	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(1), TAT(1)	414027	2	2	2	3	1	1	0	0	0	0	0.901	1.000	1.000
594	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	FMOD(1), KERA(1)	171211	2	2	2	3	1	1	0	0	0	0	0.918	1.000	1.000
595	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	PRKCA(2)	462719	2	2	2	4	2	0	0	0	0	0	0.961	1.000	1.000
596	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	CREB5(2), RAF1(1)	549915	3	2	3	3	1	1	0	1	0	0	0.947	1.000	1.000
597	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	JAK1(1), PTPRU(2)	620803	3	2	3	3	3	0	0	0	0	0	0.860	1.000	1.000
598	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH9A1(1)	391741	1	1	1	5	0	1	0	0	0	0	0.996	1.000	1.000
599	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1)	266662	1	1	1	2	0	1	0	0	0	0	0.950	1.000	1.000
600	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH9A1(1)	391741	1	1	1	5	0	1	0	0	0	0	0.996	1.000	1.000
601	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	MST1R(1)	324819	1	1	1	7	1	0	0	0	0	0	0.999	1.000	1.000
602	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	JAK1(1), JAK2(1)	517273	2	1	2	3	1	0	0	1	0	0	0.957	1.000	1.000
603	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	JAK1(1), JAK2(1)	517273	2	1	2	3	1	0	0	1	0	0	0.957	1.000	1.000
604	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9		327636	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
605	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2		82686	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
606	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8		195731	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
607	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6		243817	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
608	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		25727	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
609	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2		105566	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
610	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4		154059	0	0	0	3	0	0	0	0	0	0	1.000	1.000	1.000
611	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		77610	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
612	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5		191335	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
613	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9		432200	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
614	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4		156996	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20		847907	0	0	0	4	0	0	0	0	0	0	1.000	1.000	1.000
616	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6		370879	0	0	0	3	0	0	0	0	0	0	1.000	1.000	1.000
