		Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Chi-square test_P	Chi-square test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
TP53	35 (15%)	193	0.14268	1	0.027085	1	0.31446	1	0.13834	1	0.22544	1	0.45799	1	0.3756	1	0.12067	1
BRAF	117 (51%)	111	2.222e-07	0.000201	0.058578	1	0.031116	1	0.0098264	1	0.031391	1	8.8803e-05	0.0804	0.23133	1	0.15416	1
C15ORF23	14 (6%)	214	0.12845	1	0.2629	1	0.86034	1	0.82559	1	0.78415	1	1	1	0.7757	1	0.77911	1
CDKN2A	33 (14%)	195	0.11048	1	0.25999	1	0.37395	1	0.78937	1	0.89011	1	0.47865	1	0.73995	1	0.7308	1
NRAS	67 (29%)	161	0.0005311	0.48	0.083969	1	0.092324	1	0.32888	1	0.96562	1	0.85837	1	0.85029	1	0.82882	1
OXA1L	7 (3%)	221	0.43712	1	0.43413	1	0.61495	1	0.47172	1	0.50301	1	0.27586	1	0.61758	1	0.62738	1
STK19	11 (5%)	217	0.7369	1	0.14733	1	0.22397	1	0.99881	1	0.86136	1	0.36214	1	0.5773	1	0.6046	1
PTEN	18 (8%)	210	0.6428	1	0.21372	1	0.14937	1	0.13056	1	0.90814	1	0.062529	1	0.81862	1	0.32341	1
RAC1	17 (7%)	211	0.63124	1	0.77159	1	0.94006	1	0.46967	1	0.51222	1	0.84872	1	0.58235	1	0.32079	1
IDH1	12 (5%)	216	0.31122	1	0.33604	1	0.089075	1	0.2525	1	0.31708	1	0.79481	1	0.15989	1	0.11542	1
ACSM2B	38 (17%)	190	0.65763	1	0.44964	1	0.79211	1	0.43767	1	0.37073	1	0.58303	1	0.29564	1	0.70427	1
PPP6C	18 (8%)	210	0.55793	1	0.25358	1	0.099245	1	0.79008	1	0.55766	1	0.65317	1	0.34522	1	0.11301	1
LCE1B	12 (5%)	216	0.14641	1	0.60549	1	0.3173	1	0.85812	1	0.57116	1	0.79481	1	0.92949	1	0.91004	1
MUC7	19 (8%)	209	0.95484	1	0.48733	1	0.13051	1	0.71322	1	0.50324	1	0.037731	1	0.087017	1	0.049653	1
OR51S1	27 (12%)	201	0.31584	1	0.83975	1	0.88427	1	0.10846	1	0.38292	1	0.68998	1	0.63031	1	0.87135	1
NAP1L2	23 (10%)	205	0.70028	1	1	1	0.80156	1	0.82878	1	0.59838	1	1	1	0.92227	1	1	1
PRB2	31 (14%)	197	0.50856	1	0.53532	1	0.73346	1	0.76656	1	0.016145	1	0.038057	1	0.19551	1	0.19334	1
TAF1A	13 (6%)	215	0.67642	1	0.87741	1	0.54602	1	0.083809	1	0.82345	1	0.38811	1	0.4099	1	0.91364	1
HIST1H2AA	10 (4%)	218	0.36277	1	0.7115	1	0.65164	1	0.70851	1	0.39859	1	0.91706	1	0.31469	1	0.22852	1
FRG2B	16 (7%)	212	0.89814	1	0.71657	1	0.97542	1	0.99498	1	0.2503	1	0.83704	1	0.6026	1	0.18722	1
CDH9	33 (14%)	195	0.83929	1	0.13683	1	0.21565	1	0.56212	1	0.81651	1	0.58079	1	0.003658	1	0.41869	1
PRAMEF11	21 (9%)	207	0.77312	1	0.063101	1	0.93732	1	0.95167	1	0.21669	1	0.49664	1	0.80438	1	0.63058	1
HBG2	8 (4%)	220	0.60129	1	0.42077	1	0.25787	1	0.34399	1	0.35439	1	0.89387	1	0.11435	1	0.20636	1
DDX3X	18 (8%)	210	0.61444	1	0.95143	1	0.23055	1	0.17631	1	0.67589	1	0.9489	1	0.86179	1	0.20807	1
PRB4	19 (8%)	209	0.41029	1	0.56417	1	0.12903	1	0.17412	1	0.029854	1	0.14945	1	0.36097	1	0.26002	1
GRXCR1	18 (8%)	210	0.86682	1	0.072901	1	0.39102	1	0.95545	1	0.039199	1	1	1	0.63576	1	0.20807	1
HHLA2	17 (7%)	211	0.051862	1	0.77159	1	0.45585	1	0.0044067	1	0.89812	1	0.079456	1	0.014979	1	0.49272	1
RBM11	13 (6%)	215	0.24241	1	0.03939	1	0.77063	1	0.88126	1	0.77054	1	0.051919	1	0.21335	1	0.45354	1
FUT9	22 (10%)	206	0.41775	1	0.025842	1	0.50487	1	0.86053	1	0.44155	1	0.25411	1	0.2751	1	0.67775	1
TTN	176 (77%)	52	0.4098	1	0.013727	1	0.49483	1	0.11376	1	0.19811	1	0.21998	1	0.11917	1	0.3143	1
HBD	10 (4%)	218	0.29953	1	0.77863	1	0.83228	1	0.25229	1	0.035177	1	0.16637	1	0.55085	1	0.89081	1
KIAA1257	14 (6%)	214	0.41959	1	0.94078	1	0.58218	1	0.74693	1	0.78415	1	0.76529	1	0.56778	1	0.51481	1
USP17L2	19 (8%)	209	0.22897	1	0.1545	1	0.16726	1	0.25012	1	0.23992	1	0.35961	1	0.27936	1	0.46226	1
CADM2	23 (10%)	205	0.72881	1	0.11171	1	0.16917	1	0.37056	1	0.67533	1	0.71053	1	0.27555	1	0.0059113	1
GFRAL	31 (14%)	197	0.16388	1	0.21195	1	0.69878	1	0.74051	1	0.85892	1	0.87374	1	0.51456	1	0.95974	1
OR4N2	22 (10%)	206	0.2987	1	0.17405	1	0.61417	1	0.37033	1	0.022162	1	0.22989	1	0.60006	1	0.18452	1
UGT2B15	21 (9%)	207	0.43871	1	0.37969	1	0.81502	1	0.73987	1	0.43859	1	0.8728	1	0.15091	1	0.34473	1
UNC119B	6 (3%)	222	0.44999	1	0.44971	1	0.21258	1	0.91979	1	0.59009	1	0.55071	1	1	1	0.46189	1
RAPGEF5	12 (5%)	216	1	1	0.60549	1	0.62719	1	0.50272	1	0.49083	1	0.6855	1	0.23841	1	0.062404	1
C8A	27 (12%)	201	0.61526	1	0.080069	1	0.25593	1	0.36372	1	0.11238	1	0.68998	1	0.34043	1	0.16307	1
ANKRD20A4	5 (2%)	223	0.27021	1	0.45027	1	0.31977	1	0.14289	1	0.23011	1	0.60444	1	0.61552	1	1	1
ELF5	6 (3%)	222	1	1	1	1	0.93438	1	0.5189	1	0.59009	1	1	1	0.2044	1	0.15658	1
SPAG16	16 (7%)	212	0.8474	1	0.84911	1	0.14438	1	0.30564	1	0.10975	1	0.12319	1	0.072475	1	0.10588	1
PHGDH	9 (4%)	219	0.47988	1	0.91249	1	1	1	0.43302	1	0.76257	1	0.74674	1	0.7657	1	0.3496	1
COPG2	9 (4%)	219	0.32099	1	0.91249	1	0.27075	1	0.25968	1	0.69183	1	0.61403	1	0.90742	1	0.77943	1
GML	9 (4%)	219	0.17449	1	0.37826	1	0.94065	1	0.42935	1	0.8343	1	0.90228	1	0.18112	1	0.77943	1
TBC1D3B	5 (2%)	223	0.22507	1	0.84789	1	0.059099	1	0.24109	1	0.86106	1	1	1	0.85305	1	0.64053	1
TFEC	15 (7%)	213	1	1	0.5924	1	0.056842	1	0.074215	1	0.29459	1	1	1	0.58763	1	0.72791	1
TRAT1	13 (6%)	215	1	1	0.29009	1	0.73139	1	0.69735	1	0.31708	1	0.92573	1	0.31241	1	0.58723	1
PRR23B	15 (7%)	213	0.39209	1	0.037131	1	0.0068491	1	0.12465	1	0.53063	1	0.16168	1	0.090015	1	0.0010898	0.984
C9ORF119	8 (4%)	220	0.48257	1	0.59807	1	0.47592	1	0.5596	1	0.66474	1	0.38725	1	0.24689	1	0.30408	1
LIN7A	11 (5%)	217	0.85842	1	0.17947	1	0.55169	1	0.64417	1	0.16077	1	0.60541	1	0.12689	1	0.81023	1
PARM1	18 (8%)	210	0.86682	1	1	1	0.75013	1	0.14174	1	0.95197	1	0.85057	1	0.16103	1	0.39024	1
CCK	6 (3%)	222	0.58164	1	0.65826	1	0.31977	1	0.077061	1	0.44687	1	0.87588	1	0.57635	1	0.71353	1
FIGLA	3 (1%)	225	0.62875	1	0.62272	1	NA	NA	NA	NA	0.51401	1	0.42936	1	0.47226	1	0.68966	1
TCEB3C	26 (11%)	202	0.50626	1	0.30897	1	0.3631	1	0.55651	1	0.30832	1	0.042814	1	0.66648	1	0.25162	1
DEFB118	9 (4%)	219	0.39093	1	0.21607	1	0.93438	1	0.2836	1	0.8343	1	0.61403	1	0.69684	1	0.77943	1
VEGFC	17 (7%)	211	0.59818	1	0.12003	1	0.3342	1	0.027575	1	0.19735	1	0.29935	1	0.018162	1	0.14769	1
MARCH11	11 (5%)	217	1	1	0.85792	1	0.37425	1	0.70851	1	0.16077	1	0.14203	1	1	1	1	1
ZFP106	10 (4%)	218	0.84896	1	0.77863	1	0.23403	1	0.25731	1	0.50932	1	0.91706	1	0.55085	1	0.44694	1
PDE1A	32 (14%)	196	0.33711	1	0.91279	1	0.4751	1	0.40562	1	0.036085	1	0.22813	1	0.52296	1	0.29864	1
NUDT4	5 (2%)	223	1	1	0.3724	1	0.35693	1	0.15084	1	1	1	0.83746	1	0.53002	1	0.49838	1
FGF16	7 (3%)	221	1	1	0.79715	1	0.004686	1	0.01568	1	1	1	0.14833	1	0.093997	1	0.52376	1
OR4F6	15 (7%)	213	0.94276	1	0.43331	1	0.4326	1	0.44972	1	0.040032	1	0.16168	1	0.13026	1	0.39196	1
CD2	17 (7%)	211	0.41074	1	0.40952	1	0.75598	1	0.53952	1	0.95019	1	0.75788	1	0.76946	1	0.70329	1
EIF3D	4 (2%)	224	0.82902	1	0.83579	1	0.2405	1	0.4188	1	1	1	0.36076	1	0.56615	1	0.4292	1
MKX	15 (7%)	213	0.11989	1	0.20999	1	0.55123	1	0.97739	1	0.079515	1	0.29513	1	0.31401	1	0.49209	1
ARL16	7 (3%)	221	0.18037	1	0.34484	1	0.13778	1	0.63649	1	0.39107	1	1	1	1	1	1	1
OR2L3	15 (7%)	213	0.53126	1	0.010843	1	0.74391	1	0.48818	1	0.89211	1	0.35699	1	0.88857	1	0.42354	1
DEFB119	6 (3%)	222	1	1	0.77012	1	0.49204	1	0.88029	1	0.87685	1	0.87588	1	0.43819	1	1	1
KLHL4	21 (9%)	207	0.80747	1	0.54369	1	0.78791	1	0.85856	1	0.20761	1	0.22958	1	0.84091	1	0.34473	1
NR1H4	12 (5%)	216	0.42667	1	0.24615	1	0.34134	1	0.37525	1	0.93415	1	0.58018	1	1	1	0.37123	1
IL32	9 (4%)	219	0.39093	1	0.12612	1	0.68761	1	0.14582	1	0.52776	1	1	1	0.62869	1	1	1
DGAT2L6	11 (5%)	217	0.33856	1	0.53553	1	0.88467	1	0.11987	1	0.24283	1	0.60541	1	0.78915	1	0.81023	1
OR8D4	11 (5%)	217	0.58476	1	0.42064	1	0.07232	1	0.015148	1	0.20685	1	0.070748	1	0.5773	1	0.66689	1
GRXCR2	15 (7%)	213	0.39209	1	0.945	1	0.13384	1	0.65316	1	0.47026	1	0.46784	1	0.88857	1	0.79057	1
OR5H2	15 (7%)	213	0.70685	1	0.89034	1	0.43167	1	0.50958	1	0.89211	1	0.77451	1	0.48751	1	0.49209	1
SIGLEC14	12 (5%)	216	0.31122	1	0.24615	1	0.034959	1	0.44476	1	0.65965	1	0.79481	1	0.86763	1	0.91004	1
ZNF479	24 (11%)	204	0.65654	1	1	1	0.73933	1	0.11482	1	0.53252	1	0.42355	1	0.074008	1	0.63274	1
C2	12 (5%)	216	0.032855	1	0.28849	1	0.054874	1	0.39523	1	0.0989	1	0.58018	1	0.45023	1	0.41483	1
GH2	10 (4%)	218	0.098703	1	0.60114	1	0.85233	1	0.87971	1	0.66046	1	0.58505	1	0.46058	1	0.57342	1
GK2	29 (13%)	199	0.77072	1	0.5332	1	0.35659	1	0.2091	1	0.70073	1	0.6348	1	0.15024	1	0.80714	1
C2ORF40	7 (3%)	221	0.2361	1	0.89827	1	0.94065	1	0.72573	1	0.8924	1	0.78577	1	0.38065	1	0.62738	1
CXCR2	13 (6%)	215	0.59373	1	0.33581	1	0.86613	1	0.9544	1	0.55473	1	0.55803	1	0.81881	1	0.91364	1
RPTN	39 (17%)	189	0.31502	1	0.24347	1	0.32928	1	0.39568	1	0.029629	1	0.32884	1	0.56268	1	0.45223	1
PRIM2	13 (6%)	215	0.36632	1	0.062478	1	0.11595	1	0.45637	1	0.17366	1	0.017701	1	0.50332	1	0.41169	1
MUM1L1	26 (11%)	202	0.62907	1	0.77696	1	0.79861	1	0.098813	1	0.58661	1	0.15519	1	0.49845	1	0.58748	1
TLL1	44 (19%)	184	0.93261	1	0.018726	1	0.67045	1	0.050845	1	0.11731	1	0.10323	1	0.88696	1	0.4557	1
PRC1	13 (6%)	215	0.93779	1	0.44806	1	0.059666	1	0.7173	1	0.32043	1	0.52173	1	0.31241	1	0.54073	1
GLRB	23 (10%)	205	0.28593	1	0.4637	1	0.059756	1	0.034615	1	0.4023	1	0.26648	1	0.40774	1	0.49956	1
AREG	6 (3%)	222	0.76895	1	0.58051	1	0.38473	1	0.28688	1	0.77327	1	0.21638	1	0.76568	1	0.46189	1
SPINK13	8 (4%)	220	0.13967	1	0.46857	1	0.89288	1	0.46861	1	0.43986	1	0.44651	1	0.21961	1	0.4846	1
ACD	9 (4%)	219	0.28895	1	0.69055	1	0.47	1	0.54089	1	0.39436	1	0.13765	1	0.086231	1	0.058432	1
C2ORF39	9 (4%)	219	0.39093	1	0.21607	1	0.86613	1	0.26974	1	0.032245	1	0.017989	1	0.50336	1	0.88929	1
RERG	9 (4%)	219	0.47988	1	0.57914	1	0.29154	1	0.22821	1	0.52776	1	0.43708	1	0.18112	1	0.68787	1
TUBB8	13 (6%)	215	0.63485	1	0.82297	1	0.21176	1	0.13689	1	0.42519	1	0.37082	1	0.47147	1	0.37296	1
AGXT2	18 (8%)	210	0.7447	1	1	1	0.095928	1	0.54124	1	0.74598	1	0.80839	1	0.73803	1	0.34466	1
C9	16 (7%)	212	0.94902	1	0.515	1	0.87396	1	0.58259	1	0.72272	1	0.65962	1	0.89642	1	0.68794	1
CX3CL1	4 (2%)	224	0.13954	1	0.13435	1	NA	NA	NA	NA	1	1	0.54803	1	0.12235	1	0.4292	1
DEFB112	8 (4%)	220	0.17749	1	0.42077	1	0.39258	1	0.61598	1	0.35439	1	0.44651	1	0.90514	1	0.42084	1
FAM19A1	8 (4%)	220	0.15791	1	0.37939	1	0.45621	1	0.11744	1	0.48839	1	1	1	1	1	0.87566	1
LONRF2	16 (7%)	212	1	1	0.34133	1	0.94426	1	0.98728	1	0.94751	1	0.83704	1	0.4299	1	0.68794	1
NAP1L4	9 (4%)	219	0.025919	1	0.043846	1	0.034959	1	0.60504	1	0.63584	1	0.060586	1	0.62869	1	1	1
OR5J2	14 (6%)	214	0.57394	1	0.77864	1	0.31875	1	0.49191	1	1	1	1	1	0.055671	1	0.37024	1
POM121	14 (6%)	214	0.47384	1	0.36343	1	0.29935	1	0.2653	1	0.69418	1	0.35694	1	0.88266	1	0.55314	1
RBM22	7 (3%)	221	0.43712	1	0.12768	1	NA	NA	NA	NA	0.34183	1	0.45923	1	1	1	0.52376	1
SLC10A2	20 (9%)	208	0.42579	1	0.15348	1	0.74751	1	0.32811	1	0.16043	1	0.61529	1	0.47811	1	0.14493	1
C4ORF22	11 (5%)	217	0.63385	1	0.92651	1	0.62125	1	0.27399	1	0.86136	1	0.85006	1	0.13772	1	0.26672	1
CLEC14A	19 (8%)	209	0.027035	1	0.34738	1	0.13675	1	0.47823	1	0.26372	1	0.60353	1	0.36097	1	1	1
GNAI2	4 (2%)	224	1	1	0.36957	1	0.69591	1	0.7965	1	0.83402	1	0.80927	1	0.21855	1	0.14388	1
IGF2BP3	6 (3%)	222	0.88062	1	0.88267	1	0.86573	1	0.65943	1	0.51788	1	1	1	0.17364	1	0.71353	1
RBM46	15 (7%)	213	0.7521	1	0.17209	1	0.087177	1	0.15499	1	0.94444	1	0.68663	1	0.45761	1	0.17724	1
SERPINB4	30 (13%)	198	0.75245	1	0.90837	1	0.39478	1	0.15632	1	0.2184	1	0.37956	1	0.63496	1	0.31492	1
SORT1	10 (4%)	218	0.9204	1	0.77863	1	1	1	0.49761	1	0.25294	1	0.16637	1	1	1	0.50993	1
