rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	CDKN2A(1), E2F1(2), MDM2(1), MYC(1), PIK3CA(1), PIK3R1(4), POLR1B(1), TP53(4)	1134716	15	13	15	1	3	1	3	3	5	0	0.0234	0.00210	0.754
2	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	HRAS(1), MEF2B(1), MEF2C(1), MEF2D(1), NTRK1(4), PIK3CA(1), PIK3R1(4), RPS6KA1(3), SHC1(2)	1061373	18	13	18	2	5	3	3	2	5	0	0.0151	0.00245	0.754
3	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CDKN2A(1), E2F1(2), MDM2(1), PRB1(5), TP53(4)	471635	13	9	13	1	7	1	2	1	2	0	0.0205	0.00580	1.000
4	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(2), HDAC9(6), MEF2B(1), MEF2C(1), MEF2D(1)	421151	12	9	12	1	8	1	0	1	2	0	0.0239	0.0144	1.000
5	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(3), GNAS(3), PRKACA(1), PRKAR1A(1)	366518	8	8	7	1	6	0	0	1	1	0	0.149	0.0164	1.000
6	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(2), COQ5(1), COQ6(1), NDUFA13(1)	224210	5	5	5	1	2	0	1	1	1	0	0.393	0.0250	1.000
7	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(7), CYP2C9(3)	113730	10	8	10	4	5	1	0	3	1	0	0.449	0.0328	1.000
8	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	19	B2M(1), KLRC1(1), PIK3CA(1), PIK3R1(4), PTK2B(1), SYK(2), VAV1(2)	999149	12	9	12	1	5	1	1	2	3	0	0.0471	0.0345	1.000
9	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC1A(1), CDC42(1), PDGFRA(5), PIK3CA(1), PIK3R1(4)	755052	12	11	12	3	3	2	2	2	3	0	0.305	0.0474	1.000
10	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(3), FHL5(1), FSHR(4), GNAS(3)	532879	11	10	10	1	10	1	0	0	0	0	0.0338	0.0482	1.000
11	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(5), CCNE2(2), CDKN2A(1), E2F1(2), PRB1(5)	501991	15	8	15	1	10	0	2	2	1	0	0.0170	0.0495	1.000
12	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	CAT(1), GHR(5), HRAS(1), IGF1R(1), PIK3CA(1), PIK3R1(4), SHC1(2)	747769	15	11	15	3	8	0	2	1	4	0	0.0925	0.0561	1.000
13	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), GAD1(2), HDC(3), TPH1(4)	336252	10	7	10	1	7	1	0	2	0	0	0.0379	0.0691	1.000
14	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(3), CAMK2B(3), CAMK2G(1), GNAS(3), HRAS(1), PIK3CA(1), PIK3R1(4), PRKAR1A(1), PRKCA(1), RPS6KA1(3), SOS1(1)	1626999	22	16	21	4	12	2	2	2	4	0	0.0476	0.0851	1.000
15	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(1), BCMO1(3)	219636	5	5	5	2	3	0	0	1	1	0	0.496	0.0855	1.000
16	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(5), CUL1(2), E2F1(2), TFDP1(1)	479089	10	8	10	0	8	1	0	1	0	0	0.0126	0.0879	1.000
17	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CDO1(1), GAD1(2), GAD2(3), GGT1(1)	319432	9	6	9	1	7	0	0	2	0	0	0.0708	0.106	1.000
18	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	HRAS(1), IGF1R(1), IRS1(1), PIK3CA(1), PIK3R1(4), SHC1(2), SOS1(1)	1025175	11	9	11	1	3	0	2	2	4	0	0.111	0.110	1.000
19	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(2), EGF(1), EGFR(1), HGS(1), TF(2), TFRC(1)	720711	8	8	8	2	2	0	3	1	2	0	0.364	0.113	1.000
20	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD80(1), CD86(2), HLA-DRB1(1), ITK(1), LCK(2), PIK3CA(1), PIK3R1(4), PTPN11(1)	717699	13	8	13	3	5	0	2	2	4	0	0.221	0.116	1.000
21	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ARPC1A(1), NCKAP1(2), NTRK1(4), WASF1(1), WASF2(1)	857481	10	9	10	1	5	3	0	1	1	0	0.0856	0.120	1.000
22	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	GUSB(1), UCHL1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2B15(4), UGT2B4(5)	987513	18	14	18	4	13	1	1	2	1	0	0.0494	0.125	1.000
23	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	HRAS(1), NTRK1(4), PIK3CA(1), PIK3R1(4), PRKCA(1), SHC1(2), SOS1(1)	873858	14	11	14	3	4	2	2	3	3	0	0.176	0.126	1.000
24	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	EGFR(1), GNAS(3), HRAS(1), IGF1R(1), MAP2K2(1), MYC(1), NGFR(1), PDGFRA(5), PTPRR(2), RPS6KA1(3), SHC1(2), SOS1(1), STAT3(1)	1804489	23	16	23	2	15	2	4	2	0	0	0.00257	0.128	1.000
25	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR2(2), ITPKA(1), PDE1A(2), PDE1B(1), PLCB1(4), PLCB2(1), VIP(1)	618577	12	10	12	3	6	2	1	2	1	0	0.150	0.130	1.000
26	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	HRAS(1), MAP2K2(1), NGFR(1), NTRK1(4), PIK3CA(1), SHC1(2), SOS1(1)	856162	11	9	11	1	5	2	1	2	1	0	0.0464	0.131	1.000
27	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	DAG1(1), GNAQ(2), ITPKA(1)	337647	4	4	4	0	1	1	0	2	0	0	0.250	0.136	1.000
28	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	MAP3K14(1), RELA(1), TP53(4)	544617	6	6	6	1	2	2	0	0	2	0	0.285	0.137	1.000
29	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1D1(3), CYP11A1(2), CYP11B1(3), CYP11B2(1), HSD3B2(1)	543122	10	8	10	2	7	1	0	1	1	0	0.0761	0.146	1.000
30	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1D1(3), CYP11A1(2), CYP11B1(3), CYP11B2(1), HSD3B2(1)	543122	10	8	10	2	7	1	0	1	1	0	0.0761	0.146	1.000
31	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(2), GGT1(1), SHMT2(1)	303423	4	4	4	1	2	1	0	1	0	0	0.407	0.164	1.000
32	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(1), HLA-DRB1(1), IL1B(1), IL5RA(2)	299287	5	5	5	1	3	1	0	0	1	0	0.233	0.177	1.000
33	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25B(2), NEK1(1), WEE1(1)	388736	4	4	4	1	1	1	0	1	1	0	0.638	0.187	1.000
34	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ANGPTL2(1), DAG1(1), DGKA(1), ITGA9(1), ITPKA(1), ITPR1(7), ITPR2(1), ITPR3(3), PDE3A(3), PIK3C2G(7), PIK3CA(1), PIK3R1(4)	2683886	31	18	31	4	14	3	3	6	5	0	0.00217	0.189	1.000
35	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(1), G6PD(1), H6PD(2), PFKM(1), PGD(1), PGM3(3), PRPS1L1(1), PRPS2(1), RPIA(1), TAL1(1)	1145157	13	11	13	3	7	1	0	4	1	0	0.0941	0.200	1.000
36	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	HRAS(1), MAPK8(1), NGFR(1), PIK3CA(1), PIK3R1(4), SHC1(2), SOS1(1)	1025971	11	9	11	2	4	0	2	2	3	0	0.180	0.201	1.000
37	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	GHR(5), PIK3CA(1), PIK3R1(4), RELA(1)	786604	11	9	11	3	5	0	1	1	4	0	0.335	0.203	1.000
38	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	BCR(1), BLNK(2), HRAS(1), LYN(1), MAP3K1(1), MAPK8IP3(1), PAPPA(9), RPS6KA1(3), SHC1(2), SOS1(1), SYK(2), VAV1(2), VAV2(1), VAV3(1)	1747204	28	14	28	2	21	3	2	2	0	0	0.000205	0.209	1.000
39	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2B(3), CAMK2G(1), DAG1(1), ITPKA(1), ITPR1(7), ITPR2(1), ITPR3(3), NFAT5(1), PDE6A(3), PDE6B(2), PDE6C(4), SLC6A13(2), TF(2)	2004054	31	19	31	5	20	4	1	5	1	0	0.00185	0.214	1.000
40	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(3), FYN(1), IL7R(6), JAK3(1), LCK(2), PIK3CA(1), PIK3R1(4), PTK2B(1), STAT5A(1)	1565441	20	13	20	4	6	2	2	5	5	0	0.103	0.225	1.000
41	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIPT1(1)	86771	1	1	1	0	0	0	1	0	0	0	0.624	0.233	1.000
42	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CUL1(2), E2F1(2), FBXW7(1), TFDP1(1)	459151	6	6	6	0	5	1	0	0	0	0	0.0702	0.233	1.000
43	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	BCR(1), HRAS(1), MAP3K1(1), MAPK8(1), MYC(1), PIK3CA(1), PIK3R1(4), SOS1(1), STAT5A(1)	1529398	12	11	12	1	3	1	1	4	3	0	0.0779	0.240	1.000
44	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(1)	102044	1	1	1	0	0	1	0	0	0	0	0.642	0.243	1.000
45	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(3), GNAS(3), PLCE1(5), PRKAR1A(1)	822197	12	11	11	3	9	0	0	2	1	0	0.210	0.256	1.000
46	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	CBL(3), E2F1(2), HRAS(1), IRS1(1), JAK3(1), MYC(1), PIK3CA(1), PIK3R1(4), SHC1(2), SOS1(1), STAT5A(1), SYK(2)	2021874	20	12	20	1	6	1	2	6	5	0	0.00717	0.261	1.000
47	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP9(1), RECK(2)	418971	4	4	4	1	2	0	1	0	1	0	0.390	0.261	1.000
48	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(1), ICAM1(1), ITGA4(2), ITGB2(1), SELE(2)	673675	7	7	7	1	3	0	1	0	3	0	0.272	0.269	1.000
49	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(3), CSF1R(1), EGF(1), EGFR(1), MET(4), PDGFRA(5), PRKCA(1)	1091821	16	13	16	4	6	3	3	3	1	0	0.170	0.282	1.000
50	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(1), EGFR(1), ERBB3(1), NRG1(3)	578413	6	6	6	1	3	1	2	0	0	0	0.266	0.289	1.000
51	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD1(3), DRD2(2), GRM1(1), PLCB1(4), PPP1CA(1), PRKAR1A(1)	894207	12	10	12	4	5	3	1	1	2	0	0.344	0.293	1.000
52	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(2)	93001	2	2	2	0	2	0	0	0	0	0	0.344	0.299	1.000
53	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	41	ATF1(1), CREB5(2), CREBBP(3), DAG1(1), FRS2(1), GNAQ(2), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(1), MAPK9(2), NTRK1(4), OPN1LW(1), PIK3C2G(7), PIK3CA(1), PIK3R1(4), PTPN11(1), SHC1(2), TERF2IP(1)	2780342	39	19	39	5	19	3	3	9	5	0	0.00131	0.311	1.000
54	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(1), HSD17B2(1), HSD17B3(1), HSD17B7(1), HSD3B2(1)	451692	5	5	5	0	4	1	0	0	0	0	0.0873	0.322	1.000
55	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	27	ATF1(1), CREB5(2), DUSP4(2), EEF2K(2), EIF4E(1), MAP2K2(1), RPS6KA1(3), RPS6KA2(1), SHC1(2), SOS1(1), SOS2(2)	1522714	18	13	18	2	11	3	2	2	0	0	0.0179	0.337	1.000
56	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	HRAS(1), IGF1R(1), IRS1(1), MAPK8(1), PIK3CA(1), PIK3R1(4), PTPN11(1), SHC1(2), SOS1(1)	1347975	13	10	13	2	4	0	2	3	4	0	0.164	0.340	1.000
57	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASS(1), KARS(2)	263246	3	3	3	0	2	0	1	0	0	0	0.300	0.346	1.000
58	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	CDC42(1), HRAS(1), PIK3CA(1), PIK3R1(4), RELA(1)	1017657	8	7	8	2	2	0	1	2	3	0	0.427	0.375	1.000
59	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(1), SHMT2(1)	230400	2	2	2	1	1	1	0	0	0	0	0.628	0.382	1.000
60	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADM(1), ACSL1(2), CPT1A(1), EHHADH(1), SCP2(2)	950646	7	7	7	1	4	1	0	2	0	0	0.226	0.397	1.000
61	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CUL1(2), E2F1(2), TFDP1(1)	483056	5	5	5	0	4	1	0	0	0	0	0.0968	0.404	1.000
62	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	MAP2K2(1), MAP2K3(2), MAP3K1(1), PIK3CA(1), PIK3R1(4), RELA(1)	1044218	10	9	10	3	2	1	2	1	4	0	0.424	0.405	1.000
63	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	HRAS(1), MAP3K1(1), MAPK8(1), PDGFRA(5), PIK3CA(1), PIK3R1(4), PRKCA(1), SHC1(2), SOS1(1), STAT3(1), STAT5A(1)	1915372	19	16	19	4	8	2	3	3	3	0	0.0961	0.406	1.000
64	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1)	475994	5	5	5	1	3	1	0	1	0	0	0.289	0.408	1.000
65	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA2(1), GABRA4(1), GABRA5(1), GABRA6(2)	436504	5	5	5	1	4	0	0	1	0	0	0.312	0.413	1.000
66	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(1), HLA-DRB1(1)	170264	2	2	2	0	1	1	0	0	0	0	0.346	0.414	1.000
67	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1), GRIA2(4)	206828	5	4	5	2	5	0	0	0	0	0	0.437	0.425	1.000
68	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(2), NR1H4(2)	305149	4	4	4	1	4	0	0	0	0	0	0.299	0.428	1.000
69	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ARPC1A(1), CDC42(1), WASF1(1)	456250	4	4	4	1	2	1	0	1	0	0	0.513	0.431	1.000
70	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(3), CDC25C(1), GNAS(3), HRAS(1), MYT1(2), PRKAR1A(1), RPS6KA1(3)	1151859	15	13	14	4	11	1	1	1	1	0	0.145	0.432	1.000
71	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	SULT1A2(2), SULT1E1(4), SULT2A1(1), SUOX(1)	343556	8	6	8	3	6	1	0	0	1	0	0.403	0.437	1.000
72	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	15	BCAR1(1), PIK3CA(1), PIK3R1(4), SHC1(2), SOS1(1)	1034063	9	9	9	2	2	0	2	2	3	0	0.334	0.439	1.000
73	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	APOA4(1), CYP7A1(1), HMGCR(6), LDLR(2), LIPC(1), LRP1(9), SCARB1(1)	1543544	21	13	21	3	11	1	0	7	2	0	0.0159	0.442	1.000
74	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	21	EIF4A2(1), EIF4E(1), EIF4G1(1), GHR(5), IRS1(1), PIK3CA(1), PIK3R1(4), PRKCA(1)	1541076	15	12	15	4	7	0	1	1	6	0	0.305	0.444	1.000
75	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	CHRNB1(1), PIK3CA(1), PIK3R1(4), PTK2B(1), TERT(3)	914556	10	7	10	3	2	3	1	1	3	0	0.270	0.463	1.000
76	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(1), G6PD(1), H6PD(2), PFKM(1), PGD(1), PGM3(3), PRPS1L1(1), PRPS2(1), RPIA(1), TKTL1(1), TKTL2(5)	1358888	18	14	18	5	10	2	0	5	1	0	0.0986	0.468	1.000
77	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CREBBP(3), GNAS(3), HLA-DRB1(1), LCK(2), PRKAR1A(1), PTPRC(3)	1274929	16	13	15	3	13	0	1	1	1	0	0.0577	0.469	1.000
78	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CREBBP(3), GNAS(3), HLA-DRB1(1), LCK(2), PRKAR1A(1), PTPRC(3)	1274929	16	13	15	3	13	0	1	1	1	0	0.0577	0.469	1.000
79	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(1), CREBBP(3), PRF1(2)	593872	6	6	6	1	4	0	0	1	1	0	0.238	0.469	1.000
80	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	18	EIF4E(1), IGF1R(1), PIK3CA(1), PIK3R1(4)	1059280	7	7	7	2	2	0	1	1	3	0	0.421	0.474	1.000
81	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	MYC(1), TP53(4), WT1(1)	397838	6	6	6	3	1	1	0	1	3	0	0.693	0.478	1.000
82	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(3), C5(2), C6(10), C7(9), C8A(3), C9(3)	701493	30	13	30	9	24	2	0	2	2	0	0.0710	0.480	1.000
83	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	IL4R(1), IRS1(1), JAK3(1), PIK3CA(1), PIK3R1(4), PPP1R13B(2), SHC1(2), SOS1(1), SOS2(2), STAT6(1)	2051114	16	12	16	1	6	1	2	3	4	0	0.0187	0.480	1.000
84	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(1), ICAM1(1), ITGA4(2), ITGB2(1), SELE(2), SELP(1)	887550	8	8	8	2	4	0	1	0	3	0	0.359	0.488	1.000
85	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	15	PIK3CA(1), PTK2B(1), RBL2(2), SHC1(2), SOS1(1)	1105901	7	7	7	1	1	1	2	2	1	0	0.253	0.497	1.000
86	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	HRAS(1), INSR(2), IRS1(1), MAPK8(1), PIK3CA(1), PIK3R1(4), PTPN11(1), SHC1(2), SOS1(1)	1392059	14	9	14	3	4	0	2	4	4	0	0.251	0.503	1.000
87	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	SLPI(1)	96602	1	1	1	1	1	0	0	0	0	0	0.853	0.517	1.000
88	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	HRAS(1), PTK2B(1), SHC1(2), SOS1(1)	494953	5	4	5	0	2	1	1	1	0	0	0.149	0.518	1.000
89	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(5), CDK6(1), CDKN2A(1), E2F1(2), RBL1(1), TFDP1(1)	903066	11	8	11	2	8	0	1	2	0	0	0.135	0.521	1.000
90	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(2), ALDOB(1)	221391	3	3	3	1	3	0	0	0	0	0	0.416	0.529	1.000
91	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	FYN(1), HLA-DRB1(1), LCK(2), PTPRC(3)	498126	7	4	7	0	5	0	1	0	1	0	0.0373	0.537	1.000
92	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2), EIF2AK4(1), EIF5(1), PPP1CA(1)	651806	5	5	5	0	2	0	1	1	1	0	0.240	0.538	1.000
93	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1)	447276	6	6	6	3	4	1	0	0	1	0	0.483	0.544	1.000
94	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1)	447276	6	6	6	3	4	1	0	0	1	0	0.483	0.544	1.000
95	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(1), PRKCA(1), TGM2(1)	279183	4	3	4	1	3	0	0	0	1	0	0.375	0.547	1.000
96	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(3), PRKAR1A(1), PRKCA(1)	533508	5	5	5	2	4	0	0	0	1	0	0.617	0.548	1.000
97	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	HRAS(1), MPL(1), PIK3CA(1), PIK3R1(4), PRKCA(1), SHC1(2), SOS1(1), STAT3(1), STAT5A(1), THPO(1)	1635660	14	10	14	3	5	1	2	3	3	0	0.186	0.551	1.000
98	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	ATM(1), E2F1(2), MDM2(1), TP53(4)	1017334	8	8	8	2	3	1	1	1	2	0	0.328	0.554	1.000
99	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), IL1B(1), MST1(1), MST1R(1)	368467	4	4	4	1	3	0	0	0	1	0	0.533	0.561	1.000
100	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(1), RELA(1), XDH(6)	553453	8	7	8	3	7	1	0	0	0	0	0.386	0.566	1.000
101	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	CDK6(1), E2F1(2), HRAS(1), PIK3CA(1), PIK3R1(4), RELA(1), TFDP1(1)	1132551	11	9	11	3	5	0	1	2	3	0	0.331	0.578	1.000
102	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT9(3), HEXA(2), NAGA(1)	566756	7	6	7	2	5	0	1	1	0	0	0.278	0.579	1.000
103	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASS(1), KARS(2)	389447	3	3	3	0	2	0	1	0	0	0	0.303	0.579	1.000
104	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(3), GNAS(3), PRKAA2(2), PRKAG2(2), PRKAR1A(1)	857937	11	10	10	4	9	1	0	0	1	0	0.371	0.581	1.000
105	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	CBS(1), MUT(2)	283496	3	3	3	0	2	0	0	1	0	0	0.322	0.584	1.000
106	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(1), ICAM1(1), ITGB2(1), SELE(2)	577785	5	5	5	1	3	0	0	0	2	0	0.321	0.594	1.000
107	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1B(1), BMPR2(1)	352468	2	2	2	1	0	0	0	0	2	0	0.804	0.595	1.000
108	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(3)	272232	3	3	3	1	3	0	0	0	0	0	0.504	0.597	1.000
109	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ATM(1), ATR(5), CCNA1(5), CDK6(1), CDKN2A(1), E2F1(2), TFDP1(1), TP53(4)	1693749	20	14	20	4	10	1	2	4	3	0	0.0889	0.597	1.000
110	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT2(2)	148134	2	2	2	1	2	0	0	0	0	0	0.630	0.599	1.000
111	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	21	HRAS(1), JAK3(1), LCK(2), MAPK8(1), SHC1(2), SOS1(1), STAT5A(1), SYK(2)	1252389	11	8	11	0	6	1	2	2	0	0	0.0113	0.599	1.000
112	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), UGP2(1)	275948	2	2	2	0	1	0	0	0	1	0	0.408	0.601	1.000
113	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), ICAM1(1), ITGB2(1), PRF1(2)	486744	5	5	5	2	3	0	0	1	1	0	0.421	0.607	1.000
114	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), CSF1R(1), E2F1(2), ETS1(1), ETS2(1), HDAC5(1), HRAS(1), NCOR2(2), RBL1(1), RBL2(2), SIN3A(3)	1450925	16	10	16	2	9	2	1	3	1	0	0.0227	0.607	1.000
115	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST2(1), XYLT1(3)	359670	5	5	5	2	4	1	0	0	0	0	0.319	0.624	1.000
116	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST2(1), XYLT1(3)	359670	5	5	5	2	4	1	0	0	0	0	0.319	0.624	1.000
117	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	DAG1(1), GNAQ(2), ITPKA(1), ITPR1(7), ITPR2(1), ITPR3(3), NFKB2(1), PIK3CB(5), PLD1(1), PLD2(2)	2512798	24	15	23	7	8	2	2	10	2	0	0.211	0.624	1.000
118	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAA2(1), EHHADH(1)	469265	3	3	3	0	2	0	1	0	0	0	0.254	0.635	1.000
119	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(1), ATR(5), CDC25C(1), TP53(4)	900674	11	10	11	4	3	1	1	3	3	0	0.656	0.638	1.000
120	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CSF1(1), LDLR(2)	300636	3	3	3	0	3	0	0	0	0	0	0.213	0.640	1.000
121	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	BCAR1(1), CRK(1), CXCR4(1), GNAQ(2), HRAS(1), PIK3C2G(7), PIK3CA(1), PIK3R1(4), PRKCA(1), PTK2B(1), RELA(1)	1497606	21	13	21	6	10	2	2	3	4	0	0.151	0.641	1.000
122	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(1), PIK3R1(4), PLCB1(4), PRKCA(1), VAV1(2)	721294	12	10	12	6	5	0	2	2	3	0	0.627	0.651	1.000
123	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR2(1), TPK1(1)	359971	2	2	2	0	1	0	0	0	1	0	0.443	0.666	1.000
124	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(1), CASP8(1), TRAF2(1)	462260	4	4	4	1	4	0	0	0	0	0	0.356	0.667	1.000
125	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	HLA-DRB1(1)	131815	1	1	1	1	1	0	0	0	0	0	0.834	0.670	1.000
126	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1QB(2), C1R(1), C1S(5), C2(2), C3(3), C5(2), C6(10), C7(9), C8A(3), C9(3)	973231	41	17	41	10	31	3	1	3	3	0	0.00827	0.675	1.000
127	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(1), AGTR1(1), EGFR(1), GNAQ(2), HRAS(1), MAP2K2(1), MAP3K1(1), MAPK8(1), MEF2B(1), MEF2C(1), MEF2D(1), PRKCA(1), PTK2B(1), SHC1(2), SOS1(1), SYT1(1)	1831542	18	12	18	4	9	2	2	3	2	0	0.0932	0.677	1.000
128	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(3), CSF2RB(1), IGF1R(1), IL3RA(1), KIT(1), KITLG(1), PIK3CA(1), PIK3R1(4), PRKAR1A(1)	1231595	14	11	13	5	6	0	2	1	5	0	0.330	0.682	1.000
129	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	33	ACTA1(1), CRK(1), HGF(1), HRAS(1), MAP2K2(1), MAPK8(1), MET(4), PIK3CA(1), PIK3R1(4), PTK2B(1), PTPN11(1), SOS1(1), STAT3(1)	2363613	19	15	19	3	8	2	1	4	4	0	0.0569	0.685	1.000
130	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	FMOD(1), KERA(1), LUM(1)	199830	3	3	3	2	3	0	0	0	0	0	0.646	0.685	1.000
131	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), HMGCR(6), MVK(1), SQLE(1)	616813	9	5	9	0	4	0	0	4	1	0	0.0487	0.688	1.000
132	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ACAA2(1), ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), AKR1D1(3), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), BAAT(2), CEL(2), CYP7A1(1), SRD5A1(1), SRD5A2(1)	1307400	26	17	26	8	20	2	1	2	1	0	0.0509	0.693	1.000
133	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	APC(3), CCL13(1), DAG1(1), EGFR(1), GNAQ(2), ITPKA(1), ITPR1(7), ITPR2(1), ITPR3(3), KCNJ3(4), KCNJ5(3), MAPK10(1), PIK3CA(1), PIK3R1(4)	2902986	33	19	33	9	16	2	3	9	3	0	0.0595	0.694	1.000
134	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	MAP2K3(2), PRKAR1A(1)	678735	3	3	3	1	0	0	1	0	2	0	0.712	0.704	1.000
135	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	BTK(2), EEA1(2), LYN(1), PFKM(1), PRKCZ(1), VAV2(1)	1390778	8	7	8	2	5	0	0	1	2	0	0.222	0.711	1.000
136	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(1), IL22(1), IL22RA1(1), JAK3(1), STAT3(1), STAT5A(1), TYK2(1)	1023676	7	6	7	1	3	2	0	2	0	0	0.203	0.712	1.000
137	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(1), CDO1(1), GOT2(2), LDHA(1), LDHAL6A(1), SULT1C2(1), SULT4A1(1)	704427	8	7	8	2	6	0	0	1	1	0	0.299	0.712	1.000
138	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD80(1), HLA-DRB1(1)	221509	2	2	2	1	2	0	0	0	0	0	0.615	0.715	1.000
139	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(1), GOT2(2), LDHA(1)	385554	4	3	4	2	3	0	0	0	1	0	0.697	0.725	1.000
140	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYC(1)	374957	2	2	2	1	1	0	1	0	0	0	0.730	0.728	1.000
141	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GHR(5), HRAS(1), INSR(2), IRS1(1), PIK3CA(1), PIK3R1(4), PRKCA(1), RPS6KA1(3), SHC1(2), SOS1(1), STAT5A(1)	1816817	22	14	22	6	9	1	3	4	5	0	0.150	0.731	1.000
142	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA2(1), GABRA4(1), GABRA5(1), GABRA6(2), GPHN(2), UBQLN1(1)	662976	8	6	8	2	7	0	0	1	0	0	0.232	0.735	1.000
143	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(2), SREBF2(2)	668714	4	4	4	2	2	0	0	1	1	0	0.744	0.738	1.000
144	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	SULT1A2(2), SULT1E1(4), SULT2A1(1), SULT2B1(1), SUOX(1)	512958	9	7	9	4	7	1	0	0	1	0	0.349	0.738	1.000
145	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	BFAR(1), CREB5(2), TERF2IP(1)	543516	4	3	4	1	2	0	0	2	0	0	0.550	0.744	1.000
146	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	SQLE(1)	178374	1	1	1	0	1	0	0	0	0	0	0.609	0.745	1.000
147	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1QB(2), C1R(1), C1S(5), C2(2), C3(3), C5(2), C6(10), C7(9), C8A(3), C8B(5), C9(3), MASP1(1)	1158249	47	19	47	11	35	4	1	3	4	0	0.00295	0.746	1.000
148	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(1), EIF4E(1), LDHA(1)	503425	3	2	3	1	1	0	1	0	1	0	0.708	0.748	1.000
149	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), EHHADH(1)	680576	7	7	7	3	5	1	0	0	1	0	0.395	0.748	1.000
150	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	FYN(1), THBS1(3)	415999	4	3	4	1	3	0	0	0	1	0	0.392	0.750	1.000
151	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IL12B(1)	167006	2	1	2	1	2	0	0	0	0	0	0.660	0.758	1.000
152	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC2(1), ABCG2(1), CES2(1), CYP3A4(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1)	1284804	11	9	11	2	9	1	0	1	0	0	0.0594	0.763	1.000
153	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADM(1)	306466	1	1	1	0	0	0	0	1	0	0	0.832	0.763	1.000
154	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(3), AXIN1(1), BTRC(1), CREBBP(3), CSNK1A1(1), CTNNB1(2), MYC(1), NLK(2), TLE1(1), WIF1(1)	1640685	16	12	16	4	7	0	2	5	2	0	0.269	0.766	1.000
155	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT3(2), ST3GAL3(1)	280936	3	2	3	1	2	0	0	1	0	0	0.505	0.766	1.000
156	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(2)	475919	3	3	3	1	2	0	0	0	1	0	0.645	0.769	1.000
157	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(1), NPAS2(3), PER2(2)	956355	6	5	6	2	3	1	1	0	1	0	0.407	0.772	1.000
158	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT9(3)	336328	3	3	3	1	3	0	0	0	0	0	0.433	0.780	1.000
159	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	20	EIF4A2(1), EIF4E(1), EIF4G1(1), PIK3CA(1), PIK3R1(4), TSC2(1)	1505792	9	7	9	3	3	0	1	1	4	0	0.524	0.783	1.000
160	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACAA2(1), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH6A1(2), ALDH9A1(1), AOX1(3), BCKDHA(1), EHHADH(1), MCCC2(2), MUT(2), OXCT1(1), PCCA(2), PCCB(1)	2025923	24	14	24	5	17	1	2	2	2	0	0.0354	0.788	1.000
161	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), HMGCR(6), MVK(1), SQLE(1)	737196	9	5	9	0	4	0	0	4	1	0	0.0549	0.799	1.000
162	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(1)	219521	1	1	1	1	1	0	0	0	0	0	0.832	0.801	1.000
163	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPP(2), ALPPL2(1)	358385	4	4	4	8	2	1	0	0	1	0	0.987	0.801	1.000
164	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), IL10RA(1), STAT3(1), STAT5A(1)	686847	4	4	4	0	2	0	0	2	0	0	0.227	0.813	1.000
165	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1)	238079	1	1	1	1	1	0	0	0	0	0	0.853	0.814	1.000
166	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(6), ATM(1), CSNK1A1(1), MAPK8(1), MDM2(1), TP53(4)	1169756	14	11	14	4	7	1	2	2	2	0	0.248	0.820	1.000
167	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO2(1), IDH1(3)	502443	4	4	3	2	3	1	0	0	0	0	0.606	0.825	1.000
168	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	STX1A(1)	183803	1	1	1	1	1	0	0	0	0	0	0.787	0.828	1.000
169	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACOT11(3), DHRS2(1), EHHADH(1), ESCO1(1), ESCO2(1), ITGB1BP3(2), MYST3(1), MYST4(2)	1460909	12	9	12	3	6	1	2	2	1	0	0.253	0.830	1.000
170	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR7(1), GGCX(1), HMGCR(6), HSD17B7(1), MVK(1), SQLE(1), TM7SF2(1)	1079542	12	7	12	0	7	0	0	4	1	0	0.0102	0.830	1.000
171	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK3(1), STAT3(1), TYK2(1)	653740	3	3	3	1	1	2	0	0	0	0	0.537	0.835	1.000
172	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	APOBEC1(3), APOBEC2(1)	414701	4	4	4	2	4	0	0	0	0	0	0.580	0.835	1.000
173	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1QB(2), C1R(1), C1S(5), C2(2), C3(3), C5(2), C6(10), C7(9), C8A(3), C9(3), MASP1(1), MBL2(1)	1186699	43	17	43	11	32	4	1	3	3	0	0.00836	0.836	1.000
174	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	SQLE(1)	238765	1	1	1	0	1	0	0	0	0	0	0.616	0.841	1.000
175	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(1), HRAS(1), IL3RA(1), SHC1(2), SOS1(1), STAT5A(1)	944884	7	6	7	2	3	0	1	2	1	0	0.397	0.843	1.000
176	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(1)	428560	2	2	2	2	1	0	0	1	0	0	0.909	0.850	1.000
177	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(3), CFTR(2), GNAS(3), PRKAR1A(1)	727624	9	9	8	4	7	0	0	0	2	0	0.521	0.850	1.000
178	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(1)	173494	1	1	1	0	1	0	0	0	0	0	0.607	0.852	1.000
179	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT3(1), B4GALT5(1), ST3GAL3(1)	439468	3	3	3	2	2	0	0	0	1	0	0.681	0.852	1.000
180	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	OXCT1(1)	189754	1	1	1	0	1	0	0	0	0	0	0.655	0.854	1.000
181	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(3), C5(2), C6(10), C7(9), ICAM1(1), ITGA4(2), ITGB2(1), SELP(1), VCAM1(2)	1382673	31	14	31	9	23	2	2	1	3	0	0.0380	0.857	1.000
182	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(1), GLI2(2), GLI3(2), PRKAR1A(1), SHH(1), SMO(1), SUFU(1)	930334	9	8	9	3	6	2	0	0	1	0	0.366	0.859	1.000
183	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	IL4R(1), IRS1(1), JAK3(1), SHC1(2), STAT6(1)	828013	6	4	6	0	3	1	1	0	1	0	0.0968	0.863	1.000
184	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	GNAS(3), NOS3(1), PIK3CA(1), PIK3R1(4), RELA(1), SYT1(1)	999611	11	11	11	9	6	0	1	1	3	0	0.924	0.863	1.000
185	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFB2(1)	392185	1	1	1	0	0	0	1	0	0	0	0.677	0.870	1.000
186	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	GATA1(1), HMBS(1)	436169	2	2	2	1	1	0	0	0	1	0	0.640	0.872	1.000
187	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1)	216519	1	1	1	0	1	0	0	0	0	0	0.632	0.874	1.000
188	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABP1(2), ACADM(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), AOC2(1), CNDP1(1), DPYD(5), DPYS(2), EHHADH(1), GAD1(2), GAD2(3), MLYCD(1), SMS(1)	1514752	25	13	25	6	16	2	0	4	3	0	0.0449	0.881	1.000
189	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(3), AXIN1(1), BTRC(1), CTNNB1(2), DLL1(2)	1189128	9	7	9	2	6	0	1	1	1	0	0.224	0.882	1.000
190	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	HMGCS2(1), OXCT1(1), OXCT2(1)	402058	3	3	3	3	1	0	0	1	1	0	0.891	0.883	1.000
191	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	32	BTK(2), CDKN2A(1), DAPP1(1), INPP5D(6), PIK3CA(1), PPP1R13B(2), RPS6KA1(3), RPS6KA2(1), SHC1(2), SOS1(1), SOS2(2)	1976952	22	14	22	5	13	2	4	2	1	0	0.0797	0.884	1.000
192	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	CHAT(1), DBH(1), GAD1(2), GAD2(3), HDC(3), MAOA(1), PAH(1), SLC18A3(1), TPH1(4)	794189	17	10	17	5	14	1	0	2	0	0	0.0842	0.887	1.000
193	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	MAP3K14(1), MAPK8(1), RELA(1), TRAF2(1), TRAF6(1)	808459	5	5	5	1	4	1	0	0	0	0	0.349	0.888	1.000
194	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	SDHA(2), SDHC(1)	374105	3	3	3	2	3	0	0	0	0	0	0.738	0.888	1.000
195	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	EGF(1), EGFR(1), HRAS(1), MAP3K1(1), MAPK8(1), PIK3CA(1), PIK3R1(4), PRKCA(1), SHC1(2), SOS1(1), STAT3(1), STAT5A(1)	2058559	16	11	16	4	5	1	4	3	3	0	0.211	0.889	1.000
196	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	11	HRAS(1), MAP2K2(1), NGFR(1)	413313	3	3	3	1	3	0	0	0	0	0	0.398	0.891	1.000
197	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGF(1), EGFR(1), MAP3K1(1), NCOR2(2), THRA(2), THRB(3)	917097	10	8	10	4	4	2	2	1	1	0	0.432	0.893	1.000
198	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(1), ME1(1), PC(1)	521617	3	3	3	2	1	1	0	1	0	0	0.750	0.893	1.000
199	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15(1), ALOX15B(2), ALOX5(1), DPEP1(1), GGT1(1), PLA2G6(2), PTGS2(1), TBXAS1(3)	838295	12	11	12	5	8	1	0	1	2	0	0.290	0.894	1.000
200	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(3), PELP1(2)	826026	5	4	5	1	4	0	0	1	0	0	0.424	0.902	1.000
201	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	JAK3(1), PTPRU(1), REG1A(1), STAT3(1)	851973	4	4	4	1	2	1	0	0	1	0	0.327	0.902	1.000
202	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	EGFR(1), IGF1R(1), MYC(1), POLR2A(1), PRKCA(1), TEP1(1), TERT(3), TP53(4)	1583574	13	10	13	4	6	3	1	1	2	0	0.182	0.905	1.000
203	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), CAMK2B(3), CAMK2G(1), CLCA1(1), CLCA2(1), CLCA4(4), CNGA3(2), CNGB1(1), GUCA1C(1), PDC(1), PDE1C(3), PRKACA(1), PRKG1(1), PRKG2(3), PRKX(1)	1696325	25	14	25	7	17	2	0	4	2	0	0.0531	0.908	1.000
204	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(2), AOC2(1)	338086	3	2	3	2	2	0	0	0	1	0	0.668	0.909	1.000
205	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	PARK2(1), SNCAIP(7), UBE2F(1)	361868	9	8	9	6	7	0	1	0	1	0	0.762	0.913	1.000
206	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), FUT9(3), HEXA(2), NAGA(1)	601902	7	6	7	4	5	0	1	1	0	0	0.593	0.913	1.000
207	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(2), CYP11B2(1), HSD3B2(1)	387284	5	5	5	5	3	1	0	0	1	0	0.770	0.918	1.000
208	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(1), G6PD(1), GGT1(1), GPX5(1), IDH1(3), PGD(1)	1016033	8	8	7	3	6	0	1	1	0	0	0.300	0.918	1.000
209	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(3), ITGB3(1), PDGFRA(5), PIK3CA(1), PIK3R1(4), PLCB1(4), PRKCA(1), SMPD2(1)	1544614	20	17	19	8	11	1	3	2	3	0	0.319	0.918	1.000
210	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA1(1), ACAA2(1), ACADM(1), ALDH1B1(1), ALDH3A1(2), ALDH6A1(2), ALDH7A1(1), ALDH9A1(1), AOX1(3), BCAT2(1), BCKDHA(1), EHHADH(1), HMGCS2(1), MCCC2(2), MUT(2), OXCT1(1), OXCT2(1), PCCA(2), PCCB(1)	2419190	26	17	26	5	17	1	2	4	2	0	0.0263	0.918	1.000
211	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(2), HLA-DRB1(1), IL12B(1), IL12RB1(2), IL4R(1)	710194	7	7	7	3	6	0	0	0	1	0	0.431	0.918	1.000
212	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK3(1), PTPRU(1), REG1A(1)	766131	3	3	3	1	1	1	0	0	1	0	0.494	0.919	1.000
213	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CD8B(1), CIITA(2), CTSB(2), CTSL1(1), CTSS(1), HLA-DOA(1), HLA-DRB1(1), HLA-G(1), HSP90AA1(1), HSP90AB1(1), IFNA16(1), IFNA21(2), IFNA6(1), KIR2DL4(1), KIR2DS4(2), KIR3DL1(1), KIR3DL3(3), KLRC1(1), LGMN(1), NFYA(1), NFYC(1), PDIA3(1), TAP1(1)	2587009	30	17	30	7	17	5	2	5	1	0	0.0295	0.921	1.000
214	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA4(1), PSMA5(1)	493051	2	2	2	0	1	0	0	0	1	0	0.523	0.924	1.000
215	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), MECR(1)	476390	2	2	2	0	1	0	0	1	0	0	0.509	0.925	1.000
216	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ARG1(1)	307027	1	1	1	0	1	0	0	0	0	0	0.613	0.927	1.000
217	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	IL4R(1), INPP5D(6), JAK3(1), PIK3CA(1), PPP1R13B(2), SERPINA4(2), SHC1(2), SOS1(1), SOS2(2), STAT6(1), TYK2(1)	2067778	20	12	20	3	13	3	1	2	1	0	0.0193	0.927	1.000
218	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	IKBKB(1), RELA(1), TP53(4), WT1(1)	1013495	7	7	7	3	3	1	0	0	3	0	0.565	0.929	1.000
219	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	GOT2(2)	264740	2	2	2	2	2	0	0	0	0	0	0.827	0.929	1.000
220	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDC25B(2), CDC25C(1), SHH(1)	490559	4	3	4	3	0	2	0	1	1	0	0.928	0.929	1.000
221	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(1), CDC25B(2), CDC25C(1), MYT1(2), TP53(4), WEE1(1)	990254	11	10	11	6	3	2	1	2	3	0	0.790	0.929	1.000
222	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXTL3(1), GLCE(1), HS3ST1(1), HS3ST2(1), HS6ST2(1), HS6ST3(4), NDST3(2), NDST4(5)	1147535	16	8	16	6	11	2	1	1	1	0	0.195	0.930	1.000
223	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(1), ANAPC2(1), ANAPC5(1), BTRC(1), CDC16(1), CDC27(1), CUL1(2), CUL3(2), FBXW7(1), FZR1(1), ITCH(1)	2244050	13	12	13	3	6	1	3	1	2	0	0.236	0.930	1.000
224	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(3), NCOA3(3), PRKAR1A(1)	1160492	7	6	7	1	4	1	0	1	1	0	0.329	0.931	1.000
225	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT2(1), IARS2(1), LARS2(1), PDHA2(2)	1055053	5	5	5	1	5	0	0	0	0	0	0.277	0.933	1.000
226	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(3), HK3(2), IMPA1(1), ISYNA1(1), PGM3(3)	652450	10	7	10	6	4	2	0	2	2	0	0.583	0.935	1.000
227	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	CASP8AP2(2)	604414	2	2	2	0	1	0	0	0	1	0	0.436	0.938	1.000
228	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(3), F2R(1), GNAQ(2), PIK3CA(1), PIK3R1(4), PLCB1(4), PRKCA(1), PTK2B(1)	1448116	17	15	16	7	7	1	2	4	3	0	0.450	0.939	1.000
229	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	HEMK1(1), METTL2B(1), METTL6(1), PCYT1B(1)	787862	4	4	4	1	3	0	0	1	0	0	0.434	0.940	1.000
230	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	PTPRU(1), REG1A(1)	641018	2	2	2	1	1	0	0	0	1	0	0.658	0.940	1.000
231	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	OPRK1(2), POLR2A(1), PRKAR1A(1)	722932	4	4	4	2	3	0	0	0	1	0	0.661	0.943	1.000
232	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	LARS2(1), PDHA2(2)	565212	3	3	3	0	3	0	0	0	0	0	0.280	0.943	1.000
233	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(2), FYN(1), RELN(6)	785182	9	7	9	9	6	0	1	0	2	0	0.974	0.944	1.000
234	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(1)	566605	1	1	1	1	0	1	0	0	0	0	0.878	0.947	1.000
235	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(1), ARG1(1), CPS1(1), PYCR1(1), SMS(1)	974453	5	5	5	2	2	1	1	0	1	0	0.606	0.947	1.000
236	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(3), EGF(1), EGFR(1), HRAS(1), PTPRB(12), SHC1(2), SOS1(1), SPRY3(1), SPRY4(1)	1357019	23	14	23	6	12	0	3	6	2	0	0.199	0.948	1.000
237	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(1), SHMT2(1), TPO(5)	654036	7	4	6	2	6	1	0	0	0	0	0.197	0.948	1.000
238	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(1), CP(1), EPRS(2), GUSB(1), HMBS(1), HMOX2(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2B15(4), UGT2B4(5)	1543139	23	16	23	6	18	1	1	2	1	0	0.0533	0.949	1.000
239	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	GUSB(1), UGP2(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2A1(4), UGT2B10(2), UGT2B11(3), UGT2B15(4), UGT2B28(2), UGT2B4(5), UGT2B7(4), XYLB(1)	1515928	34	18	34	10	23	3	1	2	5	0	0.0500	0.949	1.000
240	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	18	EPO(1), HRAS(1), MAPK8(1), SHC1(2), SOS1(1), STAT5A(1)	1154337	7	6	7	2	4	0	1	2	0	0	0.390	0.950	1.000
241	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), IKBKB(1), MAP2K3(2), MAP3K1(1), MAP3K14(1), MAPK8(1), RELA(1), TRAF2(1)	1335540	9	9	9	3	5	2	1	0	1	0	0.343	0.951	1.000
242	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	EHHADH(1)	438508	1	1	1	0	1	0	0	0	0	0	0.613	0.951	1.000
243	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	APC(3), AXIN1(1), CTNNB1(2), GJA1(1), IRAK1(1), LBP(1), PIK3CA(1), PIK3R1(4), RELA(1), TLR4(3)	1712803	18	10	18	5	8	2	3	2	3	0	0.202	0.953	1.000
244	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25B(2), CDC25C(1), PRKCA(1)	521024	4	3	4	5	1	1	0	1	1	0	0.973	0.954	1.000
245	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABP1(2), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), AOC2(1), CNDP1(1), DPYD(5), DPYS(2), EHHADH(1), GAD1(2), GAD2(3), MLYCD(1), SMS(1)	1629728	26	14	26	8	17	2	0	3	4	0	0.0945	0.954	1.000
246	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	IKBKB(1), MAP3K1(1), MAP3K14(1), RELA(1), TRAF6(1)	1013183	5	4	5	1	3	2	0	0	0	0	0.369	0.955	1.000
247	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA2(1), POLE(1), POLG(1), POLG2(2), POLI(3), POLQ(2), PRIM2(1), REV1(3), REV3L(2)	2271990	16	12	16	4	9	1	1	3	2	0	0.254	0.957	1.000
248	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(3), ENPP1(2), ENPP3(1)	815580	6	5	6	3	3	2	1	0	0	0	0.608	0.959	1.000
249	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), AOC2(1), CNDP1(1), HDC(3), MAOA(1), PRPS2(1)	1366091	15	11	15	6	11	2	0	0	2	0	0.182	0.960	1.000
250	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS2(1), HEMK1(1), METTL2B(1), METTL6(1)	844543	4	4	4	1	3	0	0	1	0	0	0.405	0.961	1.000
251	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACPT(1), ALPI(1), ALPP(2), ALPPL2(1), CYP3A4(1), CYP3A43(1), CYP3A7(3), DHRS2(1), PON1(1), PON3(1)	1006757	13	12	13	9	7	2	1	1	2	0	0.734	0.962	1.000
252	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(1), CA1(2), CA2(1), CA4(1), CA7(1), CPS1(1)	1058916	8	8	8	3	4	2	0	1	1	0	0.415	0.962	1.000
253	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(1), CD44(1), CSF1(1), FCGR3A(1), IL1B(1), SPN(1), TNFRSF8(3), TNFSF8(1)	726987	10	8	10	5	6	1	0	1	2	0	0.602	0.965	1.000
254	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(1), BMPR1B(1), ESR2(2), FSHR(4), LHCGR(3), MSH5(2), NCOR1(1), NRIP1(1), PRLR(1), VDR(1), ZP2(1)	1958389	18	14	18	5	9	1	3	1	4	0	0.219	0.965	1.000
255	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(3), NRG3(1), PRKCA(1)	501083	5	4	5	3	3	0	0	1	1	0	0.786	0.966	1.000
256	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	HRAS(1), JAK3(1), PTPN11(1), SHC1(2), SOS1(1), STAT3(1)	1291523	7	5	7	0	3	1	1	2	0	0	0.0782	0.966	1.000
257	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACPT(1), ENPP1(2), ENPP3(1), MTMR2(1)	841314	5	5	5	3	0	2	1	1	1	0	0.777	0.966	1.000
258	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	BIRC3(1), CASP7(1), CASP8(1)	757545	3	3	3	1	3	0	0	0	0	0	0.536	0.967	1.000
259	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	BAIAP2(2), CASP1(1), CASP7(1), CASP8(1), GAPDH(2), INSR(2), ITCH(1), MAGI1(2), MAGI2(7)	1348832	19	9	19	8	13	1	0	3	2	0	0.412	0.968	1.000
260	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	MAFK(1), MAPK8(1), PRKCA(1)	494718	3	2	3	1	3	0	0	0	0	0	0.496	0.968	1.000
261	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1D1(3), CYP11B1(3), CYP11B2(1), HSD17B2(1), HSD17B3(1), HSD3B2(1), SRD5A1(1), SRD5A2(1), SULT1E1(4), SULT2A1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2B15(4), UGT2B4(5)	1527950	33	18	33	10	25	3	1	3	1	0	0.0291	0.969	1.000
262	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(3), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), CYP2C19(7), CYP2C9(3), DHRS2(1), EHHADH(1), ESCO1(1), ESCO2(1), MYST3(1), MYST4(2)	1736023	25	14	25	8	13	2	2	6	2	0	0.198	0.970	1.000
263	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(2)	516524	2	2	2	1	2	0	0	0	0	0	0.634	0.971	1.000
264	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	TOB1(1)	593198	1	1	1	2	0	0	0	0	1	0	0.944	0.973	1.000
265	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	HMBS(1)	424834	1	1	1	1	1	0	0	0	0	0	0.847	0.973	1.000
266	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(3), HK3(2), IMPA1(1), PGM3(3)	572913	9	7	9	6	4	2	0	2	1	0	0.686	0.973	1.000
267	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	IKBKB(1), MAP3K1(1), MAP3K14(1), RELA(1), TRAF2(1)	1253332	5	5	5	1	3	2	0	0	0	0	0.347	0.973	1.000
268	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	GORASP1(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(1), MAPK9(2), NFKB2(1), PIK3CA(1), PIK3R1(4), SYT1(1), TRAF2(1), TRAF6(1)	1874591	20	15	20	7	12	0	2	2	4	0	0.227	0.974	1.000
269	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACPT(1), ENPP1(2), ENPP3(1)	541476	4	4	4	3	0	2	1	1	0	0	0.857	0.976	1.000
270	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), CYSLTR2(2), GPR109B(1), GPR18(1), GPR39(1), GPR81(1)	549471	7	6	7	7	5	1	0	0	1	0	0.731	0.976	1.000
271	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), CPS1(1)	432747	2	2	2	2	1	1	0	0	0	0	0.869	0.976	1.000
272	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	ICAM1(1), ITGB2(1), PTPRC(3)	597674	5	4	5	2	5	0	0	0	0	0	0.410	0.977	1.000
273	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	BIRC3(1), CASP10(1), CASP7(1), CASP8(1), PRF1(2), SREBF2(2)	1023382	8	8	8	5	5	0	0	1	2	0	0.724	0.977	1.000
274	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ACOX3(2), FADS2(1)	797972	4	4	4	3	3	0	1	0	0	0	0.680	0.977	1.000
275	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ATM(1), MAPK8(1), MDM2(1), MRE11A(1), RAD51(1), RBBP8(2), RELA(1), TP53(4)	1670201	12	9	12	4	7	1	1	1	2	0	0.427	0.979	1.000
276	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(1), POLR2A(1), POLR2I(1)	753329	3	3	3	2	1	0	1	1	0	0	0.805	0.981	1.000
277	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	IKBKB(1), MAP3K1(1), MAP3K5(2), MAPK8(1), RELA(1), TRAF2(1)	1075378	7	7	7	3	6	1	0	0	0	0	0.549	0.981	1.000
278	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	ICAM1(1), ITGB2(1), PTPRC(3)	626578	5	4	5	2	5	0	0	0	0	0	0.405	0.982	1.000
279	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(1), FUT3(2), ST3GAL3(1)	401636	4	3	4	3	3	0	0	1	0	0	0.758	0.982	1.000
280	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH5A1(1), ALDH9A1(1), EHHADH(1), GAD1(2), GAD2(3), OXCT1(1), PDHA2(2)	1451462	16	10	16	5	12	1	0	2	1	0	0.154	0.982	1.000
281	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAA2(1), ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), AKR1D1(3), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), BAAT(2), CEL(2), CYP7A1(1), SLC27A5(1), SRD5A1(1), SRD5A2(1)	1778438	26	18	26	9	19	3	1	3	0	0	0.0890	0.982	1.000
282	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX3(2), FADS2(1), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2)	568420	10	7	10	6	8	0	0	2	0	0	0.645	0.982	1.000
283	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	CDC42(1), DUSP4(2), DUSP8(1), GCK(3), IL1R1(1), MAP3K1(1), MAP3K12(1), MAP3K5(2), MAP3K9(2), MAPK10(1), MAPK8(1), MAPK9(2), PAPPA(9), SHC1(2), TP53(4), TRAF6(1), ZAK(1)	2816626	35	16	35	7	21	8	1	1	4	0	0.0119	0.983	1.000
284	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(1), ESCO1(1), ESCO2(1), MYST3(1), MYST4(2)	932068	6	4	6	3	3	0	2	1	0	0	0.726	0.983	1.000
285	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	GBA(2), TPO(5)	470215	7	5	6	3	6	0	0	1	0	0	0.392	0.983	1.000
286	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF2B2(1), FLT4(4), HRAS(1), KDR(3), NOS3(1), PIK3CA(1), PIK3R1(4), PRKCA(1), SHC1(2)	1912555	18	13	18	7	11	0	2	1	4	0	0.327	0.983	1.000
287	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), POLG(1), PRPS2(1)	698244	3	2	3	1	2	0	0	0	1	0	0.645	0.984	1.000
288	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B4GALT3(1), CHST4(2), ST3GAL3(1)	695896	4	4	4	7	3	0	0	0	1	0	0.952	0.984	1.000
289	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO2(1), HAO1(1), HAO2(3)	717924	5	4	5	4	3	1	0	0	1	0	0.821	0.985	1.000
290	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT4(2), GALNT6(2), GALNT8(1), GCNT1(1), WBSCR17(2)	812003	8	6	8	4	6	0	1	0	1	0	0.532	0.985	1.000
291	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	BIRC3(1), CASP7(1), CASP8(1), MAP3K1(1), MAP3K14(1), MAPK10(1), MDM2(1), MYC(1), PARP1(2), PRF1(2), RELA(1), TNFSF10(1), TP53(4), TRAF2(1)	2090059	19	17	19	7	9	4	0	3	3	0	0.286	0.985	1.000
292	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	B4GALT3(1), B4GALT5(1), DDOST(1), MAN1A1(2), MGAT2(1), MGAT5(1)	1118698	7	7	7	5	3	1	1	0	2	0	0.764	0.985	1.000
293	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	CDC42(1), DAXX(1), HRAS(1), MAP3K1(1), MAP3K5(2), MAP3K9(2), MEF2B(1), MEF2C(1), MEF2D(1), MYC(1), SHC1(2), TRAF2(1)	2040314	15	11	15	4	8	2	1	2	2	0	0.201	0.986	1.000
294	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	EIF4E(1), IL1R1(1), WDR1(1)	597799	3	3	3	2	3	0	0	0	0	0	0.732	0.987	1.000
295	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	CHAT(1), PDHA2(2), SLC18A3(1)	386030	4	4	4	3	4	0	0	0	0	0	0.744	0.987	1.000
296	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	20	CASP8(1), MAP3K1(1), MAPK8(1), RELA(1), TRAF2(1)	1100823	5	5	5	2	4	1	0	0	0	0	0.556	0.987	1.000
297	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL12B(1), IL16(1)	556106	2	2	2	1	2	0	0	0	0	0	0.603	0.988	1.000
298	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO2(1), AFMID(1), HAO1(1), HAO2(3)	751964	6	4	6	4	4	1	0	0	1	0	0.725	0.988	1.000
299	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	CYP11A1(2), EDN1(1), EDNRA(1), EDNRB(1), PTGFR(2), PTGIR(1), PTGS2(1), TBXAS1(3)	1151998	12	9	12	6	8	1	0	1	2	0	0.514	0.989	1.000
300	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(1), CR2(1), HLA-DRB1(1), ICAM1(1), ITGB2(1), PTPRC(3)	844066	9	5	9	2	9	0	0	0	0	0	0.193	0.989	1.000
301	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(2), F2R(1), FGA(4), FGG(1), PLAT(1), PLG(3), SERPINB2(3)	749356	15	13	15	8	10	2	0	2	1	0	0.663	0.990	1.000
302	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(1), CDC25B(2), CDC25C(1), MYT1(2), WEE1(1)	775335	7	6	7	6	2	1	1	2	1	0	0.958	0.990	1.000
303	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(3), HDAC3(1), IKBKB(1), RELA(1), TRAF6(1)	1247786	7	6	7	3	5	0	0	1	1	0	0.647	0.990	1.000
304	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	ARHGAP5(1), CASP1(1), CASP10(1), CASP8(1), PRF1(2)	724299	6	5	6	4	5	0	0	0	1	0	0.728	0.990	1.000
305	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(1), CYP2A6(1), NAT2(1), XDH(6)	449615	11	9	11	7	9	1	0	1	0	0	0.424	0.991	1.000
306	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	DPYD(5), DPYS(2), ENPP1(2), ENPP3(1), PANK3(1)	779335	11	8	11	6	6	3	1	0	1	0	0.624	0.991	1.000
307	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA4(1), PSMA5(1), UBE3A(1)	726853	3	3	3	3	2	0	0	0	1	0	0.928	0.991	1.000
308	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH6A1(2), ALDH9A1(1), EHHADH(1), LDHA(1), MLYCD(1), MUT(2), PCCA(2), PCCB(1)	1862067	17	11	17	5	13	1	0	1	2	0	0.193	0.991	1.000
309	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASS(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), BBOX1(1), DOT1L(3), EHHADH(1), EHMT1(1), PLOD2(1), PLOD3(1), SHMT2(1), TMLHE(1)	2070062	17	14	17	5	13	3	0	0	1	0	0.103	0.991	1.000
310	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(2), APC(3), AXIN1(1), BMP10(2), BMP2(2), BMP5(2), BMPR2(1), CTNNB1(2), GATA4(1), MEF2C(1), NKX2-5(1), RFC1(2)	2033868	20	9	20	4	13	1	1	3	2	0	0.0719	0.991	1.000
311	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), PGK1(1)	515025	2	2	2	2	1	0	0	1	0	0	0.843	0.991	1.000
312	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT4(1), B4GALT3(1), FUT3(2), FUT9(3)	894613	7	6	7	4	5	0	0	1	1	0	0.563	0.992	1.000
313	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN2(3), BCAR1(1), CTNNA2(4), CTNNB1(2)	1062487	10	7	10	6	7	0	1	0	2	0	0.513	0.992	1.000
314	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	27	BCAR1(1), GNAQ(2), HRAS(1), MAP2K2(1), MAP2K3(2), MAP3K1(1), MAPK8(1), PRKCA(1), PTK2B(1), SHC1(2), SOS1(1), SYT1(1)	1552933	15	11	15	5	7	2	2	3	1	0	0.282	0.993	1.000
315	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A4(1), ATP6V1B2(1), ATP6V1C2(1)	846277	3	2	3	2	1	1	0	0	1	0	0.792	0.993	1.000
316	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A4(1), ATP6V1B2(1), ATP6V1C2(1)	846277	3	2	3	2	1	1	0	0	1	0	0.792	0.993	1.000
317	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A4(1), ATP6V1B2(1), ATP6V1C2(1)	846277	3	2	3	2	1	1	0	0	1	0	0.792	0.993	1.000
318	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(1), CHPF(1), DSE(1), XYLT1(3)	756015	6	5	6	4	3	2	0	1	0	0	0.612	0.993	1.000
319	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(3), DAXX(1), HRAS(1), PAX3(1), SP100(2), TP53(4)	1057508	12	8	12	6	6	2	1	1	2	0	0.555	0.994	1.000
320	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	PTPRU(1), REG1A(1), TYK2(1)	702606	3	3	3	3	1	1	0	0	1	0	0.840	0.994	1.000
321	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	LCT(3), PYGL(2)	741966	5	4	5	5	4	0	0	0	1	0	0.856	0.994	1.000
322	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	12	APC(3), CDH1(2), CREBBP(3)	1400794	8	7	8	2	7	0	0	1	0	0	0.400	0.994	1.000
323	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(1), ACO2(1), IDH1(3)	749348	5	5	4	3	3	1	0	1	0	0	0.686	0.995	1.000
324	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT6(1), AGPS(2), ENPP2(1), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PLD1(1), PLD2(2), PPAP2B(3)	1306635	17	11	17	9	11	0	1	3	2	0	0.597	0.995	1.000
325	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA4(1), PSMA5(1)	903807	2	2	2	0	1	0	0	0	1	0	0.520	0.995	1.000
326	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	UBE2I(1), UBE3A(1)	593128	2	1	2	2	2	0	0	0	0	0	0.923	0.995	1.000
327	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(4), PIGA(1), PIGN(1), PIGO(1), PIGU(1)	1341384	8	8	8	6	4	1	0	1	2	0	0.813	0.996	1.000
328	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(2), ADRA1B(1), CHRM2(1), CHRM3(3), DRD1(3), DRD2(2), DRD3(1), DRD5(1), HRH1(4), HRH2(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(1)	1418344	26	17	26	14	12	10	1	0	3	0	0.153	0.996	1.000
329	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A4(1), ATP6V1B2(1), ATP6V1C2(1)	900546	3	2	3	2	1	1	0	0	1	0	0.789	0.996	1.000
330	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	CDC42(1), CDH1(2), CTNNB1(2), CTTN(1), FYN(1), HCLS1(5), KRT18(1), NCK2(2), PRKCA(1), ROCK2(1), TLR4(3), TLR5(1), TUBA1B(1), TUBA3C(1), TUBA3D(1), TUBA3E(1), TUBAL3(2), TUBB4(1), TUBB4Q(1), TUBB8(2)	2938856	31	16	31	6	18	5	1	4	3	0	0.00566	0.996	1.000
331	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	CDC42(1), CDH1(2), CTNNB1(2), CTTN(1), FYN(1), HCLS1(5), KRT18(1), NCK2(2), PRKCA(1), ROCK2(1), TLR4(3), TLR5(1), TUBA1B(1), TUBA3C(1), TUBA3D(1), TUBA3E(1), TUBAL3(2), TUBB4(1), TUBB4Q(1), TUBB8(2)	2938856	31	16	31	6	18	5	1	4	3	0	0.00566	0.996	1.000
332	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), DAXX(1), MAPKAPK3(1)	638975	3	2	3	2	3	0	0	0	0	0	0.689	0.996	1.000
333	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), GCK(3), GNPDA2(1), HEXA(2), HK3(2), PGM3(3)	949220	12	9	12	6	7	2	1	1	1	0	0.471	0.996	1.000
334	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(4), PPP1CA(1)	1016146	5	5	5	2	4	0	1	0	0	0	0.557	0.997	1.000
335	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	82	DAXX(1), HRAS(1), IKBKB(1), MAP2K2(1), MAP2K3(2), MAP3K1(1), MAP3K12(1), MAP3K14(1), MAP3K5(2), MAP3K9(2), MAP4K4(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK4(3), MAPK8(1), MAPK9(2), MAPKAPK3(1), MEF2B(1), MEF2C(1), MEF2D(1), MYC(1), RELA(1), RPS6KA1(3), RPS6KA2(1), RPS6KA4(1), SHC1(2), TRAF2(1)	5170124	37	22	37	7	24	4	3	3	3	0	0.00484	0.997	1.000
336	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(2), EPHB1(2), FYN(1), L1CAM(1), LYN(1), SELP(1)	886792	9	7	9	6	6	1	0	1	1	0	0.774	0.997	1.000
337	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	20	CCR3(1), GNAQ(2), GNAS(3), HRAS(1), PIK3C2G(7), PLCB1(4), PRKCA(1), ROCK2(1)	1361582	20	13	20	8	11	2	2	3	2	0	0.375	0.997	1.000
338	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	BCR(1), BLNK(2), BTK(2), CD22(4), CR2(1), DAG1(1), INPP5D(6), ITPR1(7), ITPR2(1), ITPR3(3), LYN(1), PIK3CA(1), PIK3R1(4), PPP1R13B(2), PTPRC(3), SHC1(2), SOS1(1), SOS2(2), SYK(2), VAV1(2)	4148905	48	21	48	12	30	2	3	10	3	0	0.00995	0.997	1.000
339	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	EDN1(1), EPO(1), LDHA(1), NOS3(1), P4HB(1)	958170	5	3	5	3	3	1	0	0	1	0	0.850	0.998	1.000
340	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT2(1), DPYD(5), DPYS(2), ENPP1(2), ENPP3(1), PANK3(1), VNN1(1)	966873	13	10	13	7	8	3	1	0	1	0	0.565	0.998	1.000
341	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(1), CCR2(1), CCR3(1), CCR4(1), CXCR3(1), CXCR4(1), IL12B(1), IL12RB1(2), IL4R(1)	1120301	10	9	10	7	8	1	0	0	1	0	0.555	0.998	1.000
342	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(1), GOT2(2), ME1(1), ME3(2), PGK1(1), PGK2(3), RPIA(1), TKTL1(1), TKTL2(5)	1134029	17	9	17	8	11	1	0	4	1	0	0.355	0.998	1.000
343	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN2(3), ITGB3(1), SPTAN1(1), TLN1(2)	1582936	8	8	8	6	5	0	0	0	3	0	0.753	0.998	1.000
344	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	ARHGEF11(2), CDC42(1), DLG4(2), LPA(6), MAP3K1(1), MAP3K5(2), MAPK8(1), NFKB2(1), PIK3CB(5), PLD1(1), PLD2(2), ROCK2(1), SERPINA4(2)	2748740	27	17	26	9	15	1	1	6	4	0	0.230	0.998	1.000
345	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	CLOCK(1), ETV6(2), HERPUD1(1), NCKAP1(2), NCOA4(1), NR1D2(1), PER2(2), PSMA4(1), TOB1(1), UGP2(1), ZFR(1)	2047961	14	10	14	6	7	1	2	0	4	0	0.451	0.998	1.000
346	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(1), G6PD(1), GGT1(1), GPX5(1), GPX6(1), GSR(1), IDH1(3), OPLAH(2)	1229750	11	10	10	5	10	0	1	0	0	0	0.297	0.998	1.000
347	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), LDHA(1), LDHD(2), ME1(1), ME3(2), PC(1), PDHA2(2)	2075753	15	12	15	6	10	2	0	1	2	0	0.354	0.998	1.000
348	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGEF2(4), COPA(1), GPLD1(4), KDELR3(1)	917297	10	8	10	8	7	0	1	1	1	0	0.821	0.998	1.000
349	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	TPO(5)	542072	5	3	4	4	5	0	0	0	0	0	0.712	0.998	1.000
350	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(1), TYK2(1)	587082	2	2	2	2	1	1	0	0	0	0	0.870	0.998	1.000
351	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(1), TYK2(1)	587082	2	2	2	2	1	1	0	0	0	0	0.870	0.998	1.000
352	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	DAG1(1), DRD2(2), EGFR(1), EPHB2(2), ITPKA(1), ITPR1(7), ITPR2(1), ITPR3(3), KCNJ3(4), KCNJ5(3), PIK3CB(5), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), SHC1(2), SOS1(1), SOS2(2), STAT3(1), TERF2IP(1)	3194919	48	20	47	16	23	5	5	12	3	0	0.0874	0.998	1.000
353	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(2), ACY1(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), AOC2(1), ARG1(1), ASS1(1), CPS1(1), MAOA(1), SMS(1)	1640757	14	12	14	6	8	2	1	1	2	0	0.370	0.998	1.000
354	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACB(4), ACADM(1), ALDH1B1(1), ALDH3A1(2), ALDH6A1(2), ALDH7A1(1), ALDH9A1(1), EHHADH(1), LDHA(1), LDHAL6A(1), MLYCD(1), MUT(2), PCCA(2), PCCB(1)	2229712	21	12	21	5	15	2	0	3	1	0	0.0788	0.999	1.000
355	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	EGFR(1), ERBB4(3), ETS1(1), ETS2(1), ETV6(2), FMN2(3), NOTCH2(4), NOTCH4(3), PIWIL1(1), PIWIL2(2), PIWIL4(2), SOS1(1), SOS2(2)	2810247	26	16	26	9	12	1	1	7	5	0	0.368	0.999	1.000
356	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLE(1), POLG(1), POLQ(2)	936648	4	3	4	3	2	0	0	1	1	0	0.895	0.999	1.000
357	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(1), GOT2(2), ME1(1), ME3(2), PGK1(1), RPIA(1)	1013636	8	6	8	6	5	0	0	2	1	0	0.721	0.999	1.000
358	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL2(1), MAPK8(1), RELA(1), TRAF6(1)	620140	4	4	4	3	4	0	0	0	0	0	0.829	0.999	1.000
359	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CBS(1), GGT1(1), HEMK1(1), MAT2B(1), METTL2B(1), METTL6(1)	1404737	6	6	6	3	4	0	0	2	0	0	0.597	0.999	1.000
360	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(2), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), AMDHD1(1), AOC2(1), CNDP1(1), FTCD(1), HDC(3), HEMK1(1), MAOA(1), METTL2B(1), METTL6(1), PRPS2(1), UROC1(2)	2215490	21	13	21	5	15	2	0	3	1	0	0.0307	0.999	1.000
361	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	BRD4(1), CBL(3), CDC42(1), CDKN2A(1), IRS1(1), PARD3(2), PARD6A(1), PIK3CA(1), PIK3R1(4), RPS6KA1(3), RPS6KA2(1), SHC1(2), SOS1(1), SOS2(2)	3303452	24	15	24	9	6	2	4	7	5	0	0.503	0.999	1.000
362	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	GNAQ(2), MAP3K1(1), MYC(1), PRKAR1A(1), RELA(1), SYT1(1), VIP(1)	1564867	8	8	8	6	2	1	0	3	2	0	0.930	0.999	1.000
363	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(1), CA1(2), CA2(1), CA4(1), CA7(1), CPS1(1)	1183869	8	8	8	4	4	2	0	1	1	0	0.569	0.999	1.000
364	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(3), NCOA1(1)	1041758	4	4	4	2	3	0	0	1	0	0	0.790	0.999	1.000
365	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IKBKB(1), IL1B(1), IL1R1(1), IRAK1(1), MAP2K3(2), MAP3K1(1), MAP3K14(1), MAPK8(1), RELA(1), TRAF6(1)	1654462	11	8	11	4	7	2	1	0	1	0	0.348	0.999	1.000
366	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GUSB(1), HEXA(2), LCT(3)	803420	6	3	6	4	6	0	0	0	0	0	0.656	0.999	1.000
367	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1)	742311	13	10	13	6	11	1	0	1	0	0	0.344	0.999	1.000
368	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(5), COL4A2(3), COL4A3(4), COL4A4(6), COL4A5(3), COL4A6(3), P4HB(1), SLC23A1(1), SLC2A3(1)	1400270	27	15	27	6	22	3	1	1	0	0	0.266	0.999	1.000
369	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG13(1), ALG6(1), B4GALT3(1), DDOST(1), DOLPP1(1), MAN1A1(2), MAN1A2(2), MAN1C1(1), MGAT2(1), MGAT5(1), MGAT5B(1), STT3B(2)	2376182	15	9	15	8	7	2	1	1	4	0	0.549	0.999	1.000
370	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	BIRC3(1), CASP1(1), CASP10(1), CASP7(1), CASP8(1), LMNA(1), PRF1(2)	1094306	8	8	8	6	6	1	0	0	1	0	0.742	0.999	1.000
371	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	CAT(1), SHMT2(1), TPO(5)	662664	7	4	6	3	6	1	0	0	0	0	0.332	1.000	1.000
372	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(6), ABCB11(1), ABCB4(2), ABCC3(3)	799655	12	10	12	8	11	0	0	1	0	0	0.476	1.000	1.000
373	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(1), ATR(5), BRCA2(2), FANCD2(1), MRE11A(1), RAD51(1), RAD9A(1), TP53(4)	2477961	16	12	16	7	7	1	2	2	4	0	0.594	1.000	1.000
374	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(3), CREB5(2), DAG1(1), EPHB2(2), GNAQ(2), ITPKA(1), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(1), MAPK9(2)	1596584	19	13	19	9	13	1	0	3	2	0	0.551	1.000	1.000
375	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(1), BIN1(1), SYNJ1(3), SYNJ2(1), SYT1(1)	1204938	7	5	7	4	6	1	0	0	0	0	0.625	1.000	1.000
376	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	ATM(1), CASP7(1), PRKCA(1), TLN1(2), TP53(4)	1535116	9	8	9	6	5	1	1	0	2	0	0.697	1.000	1.000
377	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ADSL(1), ASNS(1), CAD(3), CRAT(1), GAD1(2), GAD2(3), GOT2(2), PC(1)	1463863	15	9	15	5	11	1	0	3	0	0	0.194	1.000	1.000
378	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1D1(3), CYP11B1(3), CYP11B2(1), CYP19A1(2), HEMK1(1), HSD17B2(1), HSD17B3(1), HSD17B7(1), HSD3B2(1), METTL2B(1), METTL6(1), SRD5A1(1), SRD5A2(1), SULT1E1(4), SULT2A1(1), SULT2B1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2A1(4), UGT2B10(2), UGT2B11(3), UGT2B15(4), UGT2B28(2), UGT2B4(5), UGT2B7(4)	2794747	55	22	55	17	40	5	2	4	4	0	0.00945	1.000	1.000
379	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CDS1(2), DGKA(1), DGKB(2), DGKD(2), DGKE(1), DGKG(3), DGKI(3), DGKZ(1), IMPA1(1), INPP4A(1), INPP4B(2), INPP5D(6), ITGB1BP3(2), ITPKA(1), ITPR1(7), ITPR2(1), ITPR3(3), OCRL(1), PIK3C2A(2), PIK3C2B(1), PIK3C2G(7), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PIP5K1B(2), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PLCD1(1), PLCD4(2), PLCE1(5), PLCZ1(6), PRKCA(1), PRKCG(1), SYNJ1(3), SYNJ2(1)	6906787	95	28	94	28	53	9	6	17	10	0	0.00172	1.000	1.000
380	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	GAL3ST1(1), GALC(1), GBA(2), LCT(3), PPAP2B(3), SMPD2(1), UGCG(1)	1347112	12	9	12	8	8	0	0	3	1	0	0.780	1.000	1.000
381	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(2), ALDH3A1(2), AOC2(1), GOT2(2), MAOA(1), TPO(5)	1229144	13	6	12	7	12	0	0	0	1	0	0.305	1.000	1.000
382	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2R(1), HRAS(1), PLCB1(4), PRKCA(1), SYK(2), TBXAS1(3)	1320316	12	10	12	6	9	0	1	1	1	0	0.554	1.000	1.000
383	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IKBKB(1), IL1R1(1), IRAK1(1), MAP3K1(1), MAP3K14(1), RELA(1), TLR4(3), TRAF6(1)	1349719	10	6	10	4	6	4	0	0	0	0	0.419	1.000	1.000
384	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(4), GABBR1(1), GPRC5D(1), GRM1(1), GRM2(2), GRM3(5), GRM4(1), GRM5(2), GRM7(7), GRM8(7)	1176071	31	16	30	16	16	3	4	2	6	0	0.233	1.000	1.000
385	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(1), RPS4Y1(1), RPS5(1), RPSA(1)	1264619	4	3	4	3	1	1	1	0	1	0	0.793	1.000	1.000
386	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), HDAC3(1), NCOA1(1), NCOA3(3), NCOR2(2), POLR2A(1)	1392567	9	6	9	5	6	1	0	1	1	0	0.624	1.000	1.000
387	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1B(1), POLR2A(1), POLR2I(1), POLR3A(1), POLR3H(1), ZNRD1(1)	1318974	6	6	6	4	3	0	1	1	1	0	0.797	1.000	1.000
388	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOB(1), GCK(3), GMPPA(1), HK3(2), PFKM(1)	1335688	8	6	8	8	5	2	0	0	1	0	0.777	1.000	1.000
389	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIT1(2), CMAS(1), GNPDA2(1), HEXA(2), HK3(2), MTMR2(1), PGM3(3)	1605454	12	9	12	6	9	0	1	1	1	0	0.479	1.000	1.000
390	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(2), DLG4(2), EPHB2(2), F2RL1(1), MAPK8(1), PLD1(1), PLD2(2), VAV1(2)	1534752	13	12	13	8	9	0	1	2	1	0	0.717	1.000	1.000
391	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACB(4), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), LDHA(1), LDHAL6A(1), LDHD(2), ME1(1), ME3(2), PC(1), PDHA2(2)	2624694	19	13	19	7	12	3	0	3	1	0	0.259	1.000	1.000
392	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(5), CALCR(2), CALCRL(1), CRHR1(1), CRHR2(2), ELTD1(2), EMR2(1), GPR64(1), LPHN1(3), LPHN2(4), LPHN3(1), SCTR(3)	1480337	26	17	26	12	13	4	2	4	3	0	0.259	1.000	1.000
393	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGT(1), AGTR1(1), AGTR2(3), CMA1(1), COL4A1(5), COL4A2(3), COL4A3(4), COL4A4(6), COL4A5(3), COL4A6(3)	1414968	31	14	31	7	28	2	1	0	0	0	0.320	1.000	1.000
394	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	APC(3), AXIN1(1), AXIN2(1), CER1(1), CSNK1A1(1), CTNNB1(2), DACT1(1), DKK2(3), LRP1(9), MVP(1), NKD2(1), SENP2(1), TSHB(1), WIF1(1)	2246687	27	12	27	10	14	1	5	7	0	0	0.319	1.000	1.000
395	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	DAXX(1), EGF(1), EGFR(1), ETS1(1), ETS2(1), HRAS(1), IKBKB(1), MAP2K3(2), MAP3K1(1), MAP3K14(1), MAP3K5(2), MAPK13(1), MAPK8(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(2), RELA(1), TRAF2(1)	2699057	22	15	22	9	13	4	3	0	2	0	0.268	1.000	1.000
396	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	ATF1(1), CDC42(1), CREB5(2), EEF2K(2), EIF4E(1), IL1R1(1), MAP2K3(2), MAP3K5(2), MAPK12(1), MAPK13(1), TRAF6(1)	1863991	15	9	15	5	12	0	1	1	1	0	0.229	1.000	1.000
397	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(2), ABP1(2), AOC2(1), DDHD1(1), ESCO1(1), ESCO2(1), MYST3(1), MYST4(2)	1421697	11	6	11	5	6	0	2	2	1	0	0.607	1.000	1.000
398	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	BIRC3(1), CASP10(1), CASP7(1), CASP8(1), GAS2(1), LMNA(1), MAP3K14(1), RELA(1), SPTAN1(1), TNFRSF10B(1), TNFSF10(1), TRAF2(1)	1873046	12	11	12	6	8	3	0	0	1	0	0.524	1.000	1.000
399	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	CREBBP(3), ERCC3(1), GRIP1(1), HDAC3(1), HDAC5(1), MEF2C(1), NCOR2(2), NRIP1(1), PELP1(2), POLR2A(1)	2558648	14	10	14	7	9	0	0	2	3	0	0.635	1.000	1.000
400	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(3), IKBKB(1), IL1B(1), MAP2K3(2), MAP3K14(1), RELA(1), TLR2(2)	1663571	11	9	11	6	6	1	1	2	1	0	0.758	1.000	1.000
401	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF2K(2), EIF2AK1(1), EIF2AK2(1), EIF2AK3(2), EIF2B2(1), EIF4A2(1), EIF4E(1), EIF4G1(1), EIF5(1), PABPC3(1)	2448944	12	9	12	6	7	0	2	1	2	0	0.687	1.000	1.000
402	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(2), BMP5(2), BMP6(1), BMP8B(1), BTRC(1), CSNK1A1(1), CSNK1A1L(1), GLI1(2), GLI2(2), GLI3(2), HHIP(2), IHH(2), LRP2(7), PRKACA(1), PRKX(1), PTCH1(2), PTCH2(2), SHH(1), SMO(1), STK36(1), SUFU(1), WNT2B(1), WNT3(1), WNT7A(1)	3385564	39	16	39	11	27	2	3	4	3	0	0.0275	1.000	1.000
403	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	34	ACTA1(1), ACTN2(3), BCAR1(1), BCR(1), CAV1(1), FYN(1), HRAS(1), MAP2K2(1), MAPK8(1), SHC1(2), SOS1(1), TLN1(2), ZYX(1)	2577948	17	10	17	9	10	0	2	2	3	0	0.534	1.000	1.000
404	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	BAG4(1), CASP8(1), LMNA(1), MADD(1), MAP3K1(1), MAPK8(1), PRKDC(2), SPTAN1(1), TRAF2(1)	2181575	10	10	10	7	6	2	0	0	2	0	0.805	1.000	1.000
405	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(1), ATP6V0A4(1), ATP6V1B2(1), ATP6V1C2(1), ATP7B(2), COX10(1), NDUFB2(1), SDHA(2)	2150830	10	9	10	5	6	1	1	1	1	0	0.554	1.000	1.000
406	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(1), CASP7(1), CASP8(1), DAXX(1), LMNA(1), MAP3K1(1), MAPK8(1), PRKDC(2), PTPN13(1), RIPK2(1), SPTAN1(1)	2295244	12	11	12	7	8	2	0	0	2	0	0.722	1.000	1.000
407	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CXCR3(1), EGF(1), EGFR(1), HRAS(1), MYLK(2), PRKAR1A(1), TLN1(2)	1821661	10	9	10	9	7	0	2	0	1	0	0.908	1.000	1.000
408	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(1), ADSL(1), ASNS(1), ASS1(1), CAD(3), CRAT(1), GAD1(2), GAD2(3), GOT2(2), PC(1), PDHA2(2)	2123837	19	12	19	7	15	1	0	3	0	0	0.199	1.000	1.000
409	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	61	BLNK(2), BTK(2), CARD11(3), CD22(4), CR2(1), HRAS(1), IKBKB(1), INPP5D(6), LYN(1), MALT1(1), NFAT5(1), NFKB2(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PPP3R2(2), RASGRP3(2), SYK(2), VAV1(2), VAV2(1), VAV3(1)	4149233	46	22	45	15	29	1	1	8	7	0	0.0678	1.000	1.000
410	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	33	ADCY1(3), GNAQ(2), GNAS(3), HRAS(1), PRKAR1A(1), PRKCA(1), SYT1(1)	1907708	12	11	11	9	9	0	0	2	1	0	0.869	1.000	1.000
411	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	32	BCR(1), BTK(2), CDKN2A(1), DAPP1(1), ITPR1(7), ITPR2(1), ITPR3(3), LYN(1), PIK3CA(1), PPP1R13B(2), PTPRC(3), RPS6KA1(3), RPS6KA2(1), SYK(2), VAV1(2)	3047771	31	20	31	10	19	2	4	5	1	0	0.0720	1.000	1.000
412	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(2), ALDH3A1(2), AOC2(1), ESCO1(1), ESCO2(1), GOT2(2), MAOA(1), MYST3(1), MYST4(2), TPO(5)	1918885	18	9	17	8	14	0	2	1	1	0	0.325	1.000	1.000
413	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ARG1(1), ASS1(1), CPS1(1), EPRS(2), GOT2(2), NOS1(7), NOS3(1), P4HA2(1), P4HA3(1), PYCR1(1), PYCR2(1), RARS(1)	2011395	20	13	20	9	16	2	1	1	0	0	0.301	1.000	1.000
414	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH5A1(1), CAD(3), CPS1(1), EPRS(2), GAD1(2), GAD2(3), GMPS(2), GOT2(2)	1863850	16	8	16	6	12	1	0	3	0	0	0.287	1.000	1.000
415	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	ERCC3(1), GTF2H4(1), POLR1B(1), POLR2A(1), POLR2I(1), POLR3E(1), POLR3H(1), TAF6(1)	1970625	8	6	8	7	4	1	1	1	1	0	0.905	1.000	1.000
416	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(1), ATP4A(2), ATP6V0A2(1), ATP6V0A4(1), ATP6V1B2(1), ATP6V1C2(1), COX10(1), COX6B2(1), NDUFA13(1), NDUFB2(1), SDHA(2), SDHC(1), UQCRC2(1)	3140466	15	13	15	6	10	1	2	1	1	0	0.321	1.000	1.000
417	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(2), ESR2(2), ESRRA(1), HNF4A(1), NR1D2(1), NR2F2(1), NR4A1(1), NR4A2(1), NR5A2(1), PPARA(1), ROR1(3), RORC(1), THRA(2), THRB(3), VDR(1)	2337608	22	12	22	8	14	3	1	2	2	0	0.135	1.000	1.000
418	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	63	ATM(1), ATR(5), BAI1(2), CASP8(1), CCNB3(2), CCNE2(2), CDK6(1), CDKN2A(1), GADD45G(1), GTSE1(2), LRDD(1), MDM2(1), RFWD2(1), RRM2B(1), SESN2(1), STEAP3(2), THBS1(3), TNFRSF10B(1), TP53(4), TP53I3(1), TSC2(1)	3594755	35	18	35	11	18	2	3	7	5	0	0.131	1.000	1.000
419	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	82	ABL2(2), ARAF(1), BTC(2), CAMK2B(3), CAMK2G(1), CBL(3), CBLB(3), CBLC(1), CRK(1), EGF(1), EGFR(1), ERBB3(1), ERBB4(3), EREG(2), HRAS(1), MAP2K2(1), MAPK10(1), MAPK8(1), MAPK9(2), MYC(1), NCK2(2), NRG1(3), NRG3(1), PAK3(2), PAK7(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PRKCA(1), PRKCG(1), SHC1(2), SHC3(1), SOS1(1), SOS2(2), STAT5A(1), TGFA(1)	5603487	63	23	62	17	34	4	4	14	7	0	0.0212	1.000	1.000
420	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	BIRC3(1), CASP1(1), CASP10(1), CASP7(1), CASP8(1), IKBKB(1), IRF3(1), IRF5(1), IRF6(4), MAP3K1(1), MAPK10(1), MDM2(1), MYC(1), PLEKHG5(3), PRF1(2), RELA(1), TNFRSF10B(1), TNFSF10(1), TP53(4), TRAF2(1)	3203347	29	20	29	11	20	4	0	2	3	0	0.173	1.000	1.000
421	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), AKAP1(1), AKAP11(5), AKAP3(5), AKAP6(4), AKAP9(4), GNAI3(1), GNAQ(2), GNB5(1), HRAS(1), ITPR1(7), KCNJ3(4), PDE1A(2), PDE1B(1), PDE1C(3), PDE4C(2), PDE4D(1), PDE7A(1), PDE7B(1), PDE8A(1), PLCB3(2), PRKACA(1), PRKAR1A(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(2), PRKCZ(1), SLC9A1(1)	6529539	73	23	72	21	47	5	2	15	4	0	0.00609	1.000	1.000
422	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	BLVRA(1), COX10(1), CP(1), EPRS(2), FTMT(1), GUSB(1), HMBS(1), HMOX2(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2A1(4), UGT2B10(2), UGT2B11(3), UGT2B15(4), UGT2B28(2), UGT2B4(5), UGT2B7(4)	2353172	40	18	40	13	30	3	1	2	4	0	0.0504	1.000	1.000
423	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(2), ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH3A1(2), AOC2(1), AOX1(3), DBH(1), GOT2(2), MAOA(1), TPO(5)	1773946	25	10	24	12	24	0	0	0	1	0	0.178	1.000	1.000
424	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	CASP1(1), CASP10(1), CASP7(1), CASP8(1), DAXX(1), IKBKE(3), NGFR(1), NTRK1(4), PTPN13(1), TRAF2(1), TRAF6(1)	2430045	16	10	16	7	13	2	0	1	0	0	0.397	1.000	1.000
425	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ALDH5A1(1), CAD(3), CPS1(1), EPRS(2), GAD1(2), GAD2(3), GMPS(2), GOT2(2), GSR(1)	2216812	17	9	17	8	13	1	0	3	0	0	0.441	1.000	1.000
426	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2H4(1), GTF2I(1), GTF2IRD1(1), STON1(1), TAF1L(6), TAF4(1), TAF4B(1), TAF6(1)	2027572	13	11	13	6	11	1	0	1	0	0	0.525	1.000	1.000
427	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	46	IMPA1(1), INPP4A(1), INPP4B(2), ISYNA1(1), ITGB1BP3(2), ITPKA(1), OCRL(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIP5K1B(2), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PLCD1(1), PLCD4(2), PLCE1(5), PLCZ1(6), SYNJ1(3), SYNJ2(1)	4094787	47	21	46	16	25	4	2	10	6	0	0.0632	1.000	1.000
428	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), AOC2(1), ARG1(1), CPS1(1), GOT2(2), MAOA(1), NOS1(7), NOS3(1), P4HA2(1), P4HA3(1), P4HB(1), PYCR1(1), RARS(1), SMS(1)	2473432	28	15	28	11	20	4	1	0	3	0	0.138	1.000	1.000
429	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	43	DDIT4(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PRKAA2(2), RHEB(1), RPS6KA1(3), RPS6KA2(1), RPS6KA6(1), STK11(1), TSC2(1), ULK1(1), ULK2(1), VEGFA(2)	2877132	27	16	26	10	11	1	3	5	7	0	0.378	1.000	1.000
430	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	APC(3), DAG1(1), DLG4(2), EPHB2(2), GNAQ(2), ITPR1(7), ITPR2(1), ITPR3(3), KCNJ3(4), KCNJ5(3), RYR1(6)	2563659	34	17	34	17	23	1	1	7	2	0	0.337	1.000	1.000
431	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP4A(1), INPP4B(2), ITPKA(1), OCRL(1), PIK3C2A(2), PIK3C2B(1), PIK3C2G(7), PIK3CA(1), PIK3CB(5), PIK3CG(1), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PLCD1(1)	2499672	35	16	34	16	16	3	3	7	6	0	0.406	1.000	1.000
432	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	ENPP1(2), ENPP3(1), G6PC(2), GBE1(1), GCK(3), GUSB(1), GYS2(2), HK3(2), MGAM(9), PGM3(3), PYGL(2), SI(10), UCHL1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2B15(4), UGT2B4(5)	3179420	55	21	55	20	37	5	3	4	6	0	0.0670	1.000	1.000
433	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	72	BTK(2), FCER1A(2), FYN(1), HRAS(1), INPP5D(6), LCP2(1), LYN(1), MAP2K2(1), MAP2K3(2), MAPK10(1), MAPK12(1), MAPK13(1), MAPK8(1), MAPK9(2), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PRKCA(1), SOS1(1), SOS2(2), SYK(2), VAV1(2), VAV2(1), VAV3(1)	3978493	52	21	51	17	31	1	2	10	8	0	0.0607	1.000	1.000
434	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	128	ACACB(4), ARAF(1), CBL(3), CBLB(3), CBLC(1), CRK(1), G6PC(2), G6PC2(3), GCK(3), GYS2(2), HRAS(1), IKBKB(1), INPP5D(6), INSR(2), IRS1(1), LIPE(1), MAP2K2(1), MAPK10(1), MAPK8(1), MAPK9(2), PDE3A(3), PFKM(1), PHKA1(4), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PPARGC1A(2), PPP1CA(1), PPP1R3A(7), PRKAA2(2), PRKACA(1), PRKAG2(2), PRKAR1A(1), PRKCZ(1), PRKX(1), PTPRF(1), PYGL(2), RHEB(1), SH2B2(1), SHC1(2), SHC3(1), SOS1(1), SOS2(2), TSC2(1)	8804607	90	23	89	25	52	5	3	15	14	1	0.00172	1.000	1.000
435	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACAA2(1), ACADM(1), ACOX3(2), ACSL1(2), ACSL5(3), ACSL6(1), ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), CPT1A(1), CPT1C(2), CYP4A11(5), CYP4A22(2), EHHADH(1), PECI(1)	2755449	36	16	36	14	31	1	1	3	0	0	0.0919	1.000	1.000
436	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ABP1(2), AFMID(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), AOC2(1), AOX1(3), ASMT(1), CAT(1), CYP1A2(2), EHHADH(1), HEMK1(1), INMT(2), LNX1(2), MAOA(1), METTL2B(1), METTL6(1), NFX1(1), OGDHL(5), TPH1(4), TPH2(4)	3389043	39	16	38	15	30	3	0	4	2	0	0.0810	1.000	1.000
437	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(1), CD1B(1), CD1E(3), CD22(4), CD33(1), CD44(1), CD5(1), CD8B(1), CR1(1), CR2(1), CSF1(1), CSF1R(1), CSF2RA(3), CSF3(1), CSF3R(2), DNTT(1), EPO(1), GYPA(1), HLA-DRB1(1), IL1B(1), IL1R1(1), IL1R2(2), IL3RA(1), IL4R(1), IL5RA(2), IL7R(6), IL9R(1), ITGA2(3), ITGA2B(1), ITGA4(2), ITGA5(5), ITGB3(1), KIT(1), KITLG(1), MME(2), MS4A1(1), TFRC(1), THPO(1), TPO(5)	4556914	66	19	65	25	43	4	5	7	7	0	0.0866	1.000	1.000
438	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), DRD1(3), DRD2(2), EGF(1), EGFR(1), GJA1(1), GJD2(2), GNAI3(1), GNAQ(2), GNAS(3), GRM1(1), GRM5(2), GUCY1A2(3), GUCY1A3(5), GUCY2D(2), GUCY2F(1), HRAS(1), HTR2A(1), HTR2C(2), ITPR1(7), ITPR2(1), ITPR3(3), MAP2K2(1), NPR1(2), PDGFB(1), PDGFC(2), PDGFD(1), PDGFRA(5), PDGFRB(2), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PRKACA(1), PRKCA(1), PRKCG(1), PRKG1(1), PRKG2(3), PRKX(1), SOS1(1), SOS2(2), TUBA1B(1), TUBA3C(1), TUBA3D(1), TUBA3E(1), TUBAL3(2), TUBB4(1), TUBB4Q(1), TUBB8(2)	7317053	106	26	104	31	67	11	8	15	5	0	0.000135	1.000	1.000
439	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	BCR(1), BLNK(2), BTK(2), DAG1(1), EPHB2(2), ITPKA(1), LYN(1), MAP2K2(1), NFAT5(1), NFKB2(1), PIK3CA(1), PIK3R1(4), PPP1R13B(2), SERPINA4(2), SHC1(2), SOS1(1), SOS2(2), SYK(2), VAV1(2)	2914320	31	19	31	13	20	1	2	4	4	0	0.311	1.000	1.000
440	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(2), AMHR2(1), BMP2(2), BMP5(2), BMP6(1), BMP8B(1), BMPR1B(1), BMPR2(1), CREBBP(3), CUL1(2), GDF5(1), INHBA(3), INHBB(1), LEFTY1(1), LTBP1(2), MYC(1), PPP2R2B(1), RBL1(1), RBL2(2), ROCK2(1), SMAD1(1), SMAD7(1), TFDP1(1), THBS1(3), THBS2(1), THBS3(1)	5554505	38	20	38	12	23	3	2	6	4	0	0.117	1.000	1.000
441	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	91	CARD11(3), CBL(3), CBLB(3), CBLC(1), CD8B(1), CDC42(1), FYN(1), GRAP2(1), HRAS(1), IKBKB(1), ITK(1), LCK(2), LCP2(1), MALT1(1), MAP3K14(1), NCK2(2), NFAT5(1), NFKB2(1), PAK3(2), PAK7(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PPP3R2(2), PRKCQ(2), PTPRC(3), RASGRP1(2), SOS1(1), SOS2(2), VAV1(2), VAV2(1), VAV3(1)	5659862	57	21	56	21	30	4	3	10	10	0	0.158	1.000	1.000
442	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASS(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), BBOX1(1), DOT1L(3), EHHADH(1), EHMT1(1), NSD1(1), OGDHL(5), PLOD2(1), PLOD3(1), SETD1A(1), SETD7(1), SHMT2(1), SUV39H2(1), TMLHE(1)	3249561	25	15	25	11	18	5	0	2	0	0	0.278	1.000	1.000
443	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), AGPAT6(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), CEL(2), DGAT2(1), DGKA(1), DGKB(2), DGKD(2), DGKE(1), DGKG(3), DGKI(3), DGKZ(1), GK2(3), LCT(3), LIPC(1), PNLIP(1), PNLIPRP2(1), PPAP2B(3)	3296320	42	20	42	20	32	5	1	3	1	0	0.201	1.000	1.000
444	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(2), ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH3A1(2), AOC2(1), AOX1(3), DBH(1), ESCO1(1), ESCO2(1), GOT2(2), HEMK1(1), MAOA(1), METTL2B(1), METTL6(1), MYST3(1), MYST4(2), TPO(5)	3328573	33	13	32	14	28	0	2	2	1	0	0.180	1.000	1.000
445	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(3), DLL1(2), DLL3(1), DLL4(1), DTX1(1), DTX3(2), JAG1(2), JAG2(1), MAML3(2), MFNG(1), NCOR2(2), NOTCH2(4), NOTCH4(3), NUMB(2), NUMBL(1), PSENEN(1)	3851023	29	14	29	12	19	3	0	6	1	0	0.349	1.000	1.000
446	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ANAPC1(1), ANAPC2(1), ANAPC5(1), ATM(1), ATR(5), BUB1(3), CCNA1(5), CCNB3(2), CCNE2(2), CDC14A(1), CDC16(1), CDC25B(2), CDC25C(1), CDC27(1), CDC7(1), CDK6(1), CDKN2A(1), CREBBP(3), CUL1(2), E2F1(2), E2F3(1), FZR1(1), GADD45G(1), MCM2(1), MCM4(2), MCM6(1), MDM2(1), PRKDC(2), RBL1(1), RBL2(2), SMC1B(1), TFDP1(1), TP53(4), WEE1(1)	7645431	57	26	56	18	23	3	8	14	9	0	0.203	1.000	1.000
447	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(5), ADORA2B(2), ADRA1A(2), ADRA1B(1), AGTR1(1), AGTR2(3), BDKRB2(1), C3AR1(1), CALCR(2), CALCRL(1), CCKAR(1), CCKBR(2), CHRM2(1), CHRM3(3), CRHR1(1), CRHR2(2), CYSLTR1(1), CYSLTR2(2), DRD1(3), DRD2(2), DRD3(1), DRD5(1), EDNRA(1), EDNRB(1), F2R(1), F2RL1(1), FPR1(2), FSHR(4), GABBR1(1), GABRA2(1), GABRA4(1), GABRA5(1), GABRA6(2), GABRB2(1), GABRB3(2), GABRG1(1), GABRG2(1), GABRP(2), GABRQ(4), GABRR1(1), GALR2(1), GHR(5), GHSR(3), GLRA1(1), GLRA2(1), GLRA3(2), GLRB(3), GPR50(3), GPR83(1), GRIA1(7), GRIA2(4), GRIA4(1), GRID1(2), GRID2(1), GRIK1(1), GRIK2(1), GRIK3(2), GRIK4(2), GRIK5(2), GRIN2A(5), GRIN2B(3), GRIN3A(2), GRIN3B(1), GRM1(1), GRM2(2), GRM3(5), GRM4(1), GRM5(2), GRM6(3), GRM7(7), GRM8(7), HCRTR1(1), HCRTR2(3), HRH1(4), HRH2(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(1), LEPR(3), LHCGR(3), MAS1(1), MC5R(1), MCHR1(1), MCHR2(3), NMBR(2), NMUR2(1), NPBWR2(2), NPFFR2(1), NPY2R(2), NPY5R(2), OPRK1(2), P2RX1(1), P2RX2(1), P2RX3(1), P2RY10(1), P2RY14(1), P2RY8(2), PARD3(2), PRLHR(1), PRLR(1), PRSS1(2), PTGFR(2), PTGIR(1), PTH2R(2), RXFP1(4), RXFP2(2), SCTR(3), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(1), TAAR5(1), TACR1(1), TACR2(1), TACR3(3), THRA(2), THRB(3), TRHR(2), TSHB(1), TSHR(3)	12346560	237	33	236	130	144	31	14	21	27	0	0.0106	1.000	1.000
448	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), ADRA1A(2), ADRA1B(1), ATP1B2(2), ATP2A2(2), ATP2A3(2), ATP2B1(2), ATP2B2(6), CACNA1A(4), CACNA1B(2), CACNA1C(3), CACNA1D(5), CACNA1E(4), CACNA1S(2), CAMK1(1), CAMK2B(3), CAMK2G(1), CAMK4(2), CASQ1(1), CASQ2(1), CHRM2(1), CHRM3(3), GJA1(1), GJB4(1), GNAI3(1), GNAQ(2), GNB5(1), ITPR1(7), ITPR2(1), ITPR3(3), KCNB1(6), KCNJ3(4), KCNJ5(3), MIB1(1), PKIA(1), PLCB3(2), PRKACA(1), PRKAR1A(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(2), PRKCZ(1), RGS18(2), RGS3(1), RGS4(1), RGS6(2), RGS7(4), RGS9(1), RYR1(6), RYR2(6), RYR3(3), SLC8A1(6), SLC8A3(5)	10452721	144	32	142	72	94	14	6	19	11	0	0.0473	1.000	1.000
449	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	244	BDNF(2), CACNA1A(4), CACNA1B(2), CACNA1C(3), CACNA1D(5), CACNA1E(4), CACNA1F(1), CACNA1H(3), CACNA1I(1), CACNA1S(2), CACNA2D1(4), CACNA2D2(1), CACNA2D3(4), CACNA2D4(1), CACNB2(1), CACNG3(1), CACNG5(2), CACNG6(1), CACNG7(1), CDC25B(2), CDC42(1), CRK(1), DAXX(1), DUSP16(1), DUSP3(1), DUSP4(2), DUSP8(1), ECSIT(2), EGF(1), EGFR(1), FGF13(2), FGF16(1), FGFR2(1), FGFR3(1), FGFR4(1), FLNB(5), FLNC(4), GADD45G(1), HRAS(1), IKBKB(1), IL1B(1), IL1R1(1), IL1R2(2), MAP2K2(1), MAP2K3(2), MAP3K1(1), MAP3K12(1), MAP3K14(1), MAP3K5(2), MAP4K4(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(1), MAPK9(2), MAPKAPK3(1), MAPT(2), MEF2C(1), MRAS(1), MYC(1), NF1(7), NFKB2(1), NLK(2), NR4A1(1), NTRK1(4), PDGFB(1), PDGFRA(5), PDGFRB(2), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PPP3R2(2), PRKACA(1), PRKCA(1), PRKCG(1), PRKX(1), PTPN5(1), PTPN7(1), PTPRR(2), RAPGEF2(1), RASA2(1), RASGRF1(3), RASGRF2(1), RASGRP1(2), RASGRP2(1), RASGRP3(2), RASGRP4(1), RPS6KA1(3), RPS6KA2(1), RPS6KA4(1), RPS6KA6(1), SOS1(1), SOS2(2), TAOK1(1), TAOK2(2), TAOK3(1), TP53(4), TRAF2(1), TRAF6(1), ZAK(1)	15727046	176	32	174	93	105	18	10	25	18	0	0.360	1.000	1.000
450	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(3), ADCY3(1), ADCY4(2), ADCY8(6), ADORA2B(2), ADRA1A(2), ADRA1B(1), AGTR1(1), ATP2A2(2), ATP2A3(2), ATP2B1(2), ATP2B2(6), ATP2B4(1), BDKRB2(1), CACNA1A(4), CACNA1B(2), CACNA1C(3), CACNA1D(5), CACNA1E(4), CACNA1F(1), CACNA1H(3), CACNA1I(1), CACNA1S(2), CAMK2B(3), CAMK2G(1), CAMK4(2), CCKAR(1), CCKBR(2), CHRM2(1), CHRM3(3), CYSLTR1(1), CYSLTR2(2), DRD1(3), EDNRA(1), EDNRB(1), EGFR(1), ERBB3(1), ERBB4(3), F2R(1), GNAQ(2), GNAS(3), GRIN2A(5), GRM1(1), GRM5(2), HRH1(4), HRH2(1), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(1), ITPKA(1), ITPR1(7), ITPR2(1), ITPR3(3), LHCGR(3), MYLK(2), MYLK2(3), NOS1(7), NOS3(1), P2RX1(1), P2RX2(1), P2RX3(1), PDE1A(2), PDE1B(1), PDE1C(3), PDGFRA(5), PDGFRB(2), PHKA1(4), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PLCD1(1), PLCD4(2), PLCE1(5), PLCZ1(6), PPP3R2(2), PRKACA(1), PRKCA(1), PRKCG(1), PRKX(1), PTGFR(2), PTK2B(1), RYR1(6), RYR2(6), RYR3(3), SLC8A1(6), SLC8A2(2), SLC8A3(5), TACR1(1), TACR2(1), TACR3(3), TRHR(2), TRPC1(1)	14975352	225	32	223	120	147	22	10	28	17	1	0.0342	1.000	1.000
451	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTN2(3), DMD(3), MYBPC1(1), MYBPC2(2), MYBPC3(3), MYH7(4), MYH8(7), MYOM1(1), NEB(12), TNNI1(1), TNNI2(1), TTN(132)	7537263	171	32	170	66	126	9	5	20	11	0	0.0192	1.000	1.000
452	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	CHAD(1), COL11A1(7), COL11A2(4), COL17A1(2), COL1A1(3), COL1A2(3), COL2A1(1), COL3A1(8), COL4A1(5), COL4A2(3), COL4A4(6), COL4A6(3), COL5A1(2), COL5A2(4), COL5A3(4), COL6A1(1), COL6A3(3), COL6A6(6), DSC1(5), DSC3(3), DSG1(5), DSG2(1), DSG3(5), DSG4(6), FN1(4), GJA1(1), GJA10(1), GJB4(1), GJC1(1), GJC2(1), GJC3(1), GJD2(2), GJD4(1), IBSP(1), INA(2), ITGB4(2), KRT10(1), KRT12(1), KRT15(2), KRT16(1), KRT17(1), KRT18(1), KRT2(1), KRT24(1), KRT28(1), KRT3(3), KRT31(3), KRT32(1), KRT35(1), KRT38(1), KRT39(1), KRT4(1), KRT5(3), KRT6A(1), KRT6B(2), KRT7(1), KRT71(2), KRT72(1), KRT73(1), KRT74(1), KRT75(2), KRT78(1), KRT8(1), KRT82(1), KRT83(1), LAMA1(5), LAMA2(3), LAMA3(6), LAMA5(2), LAMB1(1), LAMB3(4), LAMB4(3), LAMC2(1), LAMC3(1), LMNA(1), RELN(6), THBS1(3), THBS2(1), THBS3(1), TNR(6), TNXB(15), VWF(2)	13970829	209	29	208	103	156	16	5	15	17	0	0.330	1.000	1.000
453	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(3), BDKRB2(1), C1QA(1), C1QB(2), C1QC(1), C1R(1), C1S(5), C2(2), C3(3), C3AR1(1), C4BPA(2), C5(2), C6(10), C7(9), C8A(3), C8B(5), C9(3), CFB(1), CFH(6), CFI(3), CR1(1), CR2(1), F10(2), F11(3), F13A1(2), F13B(1), F2R(1), F3(2), F5(7), F7(2), F8(4), FGA(4), FGG(1), KLKB1(2), KNG1(3), MASP1(1), MBL2(1), PLAT(1), PLG(3), PROC(1), SERPINA5(2), SERPINC1(1), SERPIND1(1), SERPINF2(2), TFPI(2), VWF(2)	5063859	117	29	117	41	84	7	2	13	11	0	0.0191	1.000	1.000
454	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	189	ACTN2(3), ARHGAP5(1), BCAR1(1), BIRC3(1), CAV1(1), CDC42(1), CHAD(1), COL11A1(7), COL11A2(4), COL1A1(3), COL1A2(3), COL2A1(1), COL3A1(8), COL4A1(5), COL4A2(3), COL4A4(6), COL4A6(3), COL5A1(2), COL5A2(4), COL5A3(4), COL6A1(1), COL6A3(3), COL6A6(6), CRK(1), CTNNB1(2), EGF(1), EGFR(1), FARP2(1), FLNB(5), FLNC(4), FN1(4), FYN(1), GRLF1(1), HGF(1), HRAS(1), IBSP(1), IGF1R(1), ITGA10(3), ITGA11(1), ITGA2(3), ITGA2B(1), ITGA4(2), ITGA5(5), ITGA7(2), ITGA9(1), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(1), KDR(3), LAMA1(5), LAMA2(3), LAMA3(6), LAMA5(2), LAMB1(1), LAMB3(4), LAMB4(3), LAMC2(1), LAMC3(1), MAPK10(1), MAPK8(1), MAPK9(2), MET(4), MYLK(2), MYLK2(3), PAK3(2), PAK7(1), PARVA(1), PARVG(1), PDGFB(1), PDGFC(2), PDGFD(1), PDGFRA(5), PDGFRB(2), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PPP1CA(1), PPP1R12A(1), PRKCA(1), PRKCG(1), RELN(6), ROCK2(1), SHC1(2), SHC3(1), SOS1(1), SOS2(2), THBS1(3), THBS2(1), THBS3(1), TLN1(2), TLN2(2), TNR(6), TNXB(15), VAV1(2), VAV2(1), VAV3(1), VEGFA(2), VWF(2), ZYX(1)	20614013	246	28	244	101	171	15	12	28	20	0	0.0363	1.000	1.000
455	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	129	ACTN2(3), ASH1L(2), CASK(1), CDC42(1), CGN(1), CLDN11(1), CLDN17(1), CLDN6(1), CSNK2B(1), CTNNA2(4), CTNNA3(2), CTNNB1(2), CTTN(1), EPB41L1(1), EPB41L2(2), GNAI3(1), HCLS1(5), HRAS(1), IGSF5(1), INADL(3), LLGL2(2), MAGI1(2), MAGI2(7), MPDZ(1), MRAS(1), MYH1(11), MYH11(2), MYH13(3), MYH15(3), MYH2(9), MYH4(6), MYH7(4), MYH8(7), PARD3(2), PARD6A(1), PARD6B(1), PPP2R2B(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(2), PRKCZ(1), SPTAN1(1), SYMPK(1), TJP2(1), TJP3(3), ZAK(1)	10776347	111	28	111	73	78	17	1	9	6	0	0.619	1.000	1.000
456	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), ATF1(1), ATP2A2(2), ATP2A3(2), CAMK2B(3), CAMK2G(1), CNN1(1), CORIN(5), CRHR1(1), DGKZ(1), ETS2(1), GABPB2(1), GJA1(1), GNAQ(2), GNB5(1), GUCY1A3(5), IL1B(1), ITPR1(7), ITPR2(1), ITPR3(3), MIB1(1), MYLK2(3), NOS1(7), NOS3(1), PDE4D(1), PKIA(1), PLCB3(2), PLCD1(1), PRKACA(1), PRKAR1A(1), PRKCA(1), PRKCH(1), PRKCQ(2), PRKCZ(1), RGS18(2), RGS3(1), RGS4(1), RGS6(2), RGS7(4), RGS9(1), RYR1(6), RYR2(6), RYR3(3), SLC8A1(6), TNXB(15)	9733860	127	28	125	57	85	12	6	15	9	0	0.0289	1.000	1.000
457	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1(2), AMHR2(1), BMP2(2), BMPR1B(1), BMPR2(1), CCL13(1), CCL23(1), CCR1(1), CCR2(1), CCR3(1), CCR4(1), CCR6(1), CSF1(1), CSF1R(1), CSF2RA(3), CSF2RB(1), CSF3(1), CSF3R(2), CXCL9(1), CXCR3(1), CXCR4(1), EDA2R(1), EGF(1), EGFR(1), EPO(1), FLT4(4), GDF5(1), GHR(5), HGF(1), IFNA16(1), IFNA21(2), IFNA6(1), IL10RA(1), IL12B(1), IL12RB1(2), IL15RA(1), IL17A(1), IL17RA(2), IL18RAP(3), IL19(1), IL1B(1), IL1R1(1), IL1R2(2), IL20RA(1), IL21R(1), IL22(1), IL22RA1(1), IL28A(1), IL29(1), IL3RA(1), IL4R(1), IL5RA(2), IL7R(6), IL9R(1), INHBA(3), INHBB(1), KDR(3), KIT(1), KITLG(1), LEPR(3), MET(4), MPL(1), NGFR(1), OSM(3), OSMR(5), PDGFB(1), PDGFC(2), PDGFRA(5), PDGFRB(2), PRLR(1), TNFRSF10B(1), TNFRSF10D(1), TNFRSF8(3), TNFSF10(1), TNFSF14(4), TNFSF8(1), TPO(5), VEGFA(2)	9909965	133	27	132	71	90	10	7	12	14	0	0.282	1.000	1.000
458	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	200	ACTN2(3), APC(3), ARAF(1), ARHGEF12(1), ARHGEF4(2), ARHGEF7(1), ARPC1A(1), BAIAP2(2), BCAR1(1), BDKRB2(1), CDC42(1), CHRM2(1), CHRM3(3), CRK(1), CYFIP2(1), DIAPH3(1), EGF(1), EGFR(1), F2R(1), FGD1(1), FGF13(2), FGF16(1), FGFR2(1), FGFR3(1), FGFR4(1), FN1(4), GRLF1(1), HRAS(1), IQGAP2(2), IQGAP3(1), ITGA10(3), ITGA11(1), ITGA2(3), ITGA2B(1), ITGA4(2), ITGA5(5), ITGA7(2), ITGA9(1), ITGAD(2), ITGAE(3), ITGAX(2), ITGB2(1), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(1), MAP2K2(1), MRAS(1), MYLK(2), MYLK2(3), NCKAP1(2), NCKAP1L(3), PAK3(2), PAK7(1), PDGFB(1), PDGFRA(5), PDGFRB(2), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PIP5K1B(2), PPP1CA(1), PPP1R12A(1), ROCK2(1), SCIN(1), SLC9A1(1), SOS1(1), SOS2(2), SSH2(1), TIAM1(2), TIAM2(2), VAV1(2), VAV2(1), VAV3(1), WASF1(1), WASF2(1)	15274521	130	27	129	85	83	4	6	23	14	0	0.873	1.000	1.000
459	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA2B(2), ADRA1A(2), ADRA1B(1), AGTR1(1), AGTR2(3), BDKRB2(1), C3AR1(1), CCKAR(1), CCKBR(2), CCR1(1), CCR2(1), CCR3(1), CCR4(1), CCR6(1), CCRL1(1), CHRM2(1), CHRM3(3), CMKLR1(1), CXCR3(1), CXCR4(1), DRD1(3), DRD2(2), DRD3(1), DRD5(1), EDNRA(1), EDNRB(1), F2R(1), F2RL1(1), FPR1(2), FSHR(4), GALR2(1), GHSR(3), GPR50(3), GPR83(1), GPR87(1), HCRTR1(1), HCRTR2(3), HRH1(4), HRH2(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(1), LHCGR(3), MAS1(1), MC5R(1), NMBR(2), NMUR2(1), NPY2R(2), NPY5R(2), OPRK1(2), OR11A1(1), OR1C1(2), OR1F1(2), OR1Q1(1), OR5V1(1), OR7A5(1), P2RY10(1), P2RY14(1), PTGFR(2), PTGIR(1), RGR(1), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(1), SUCNR1(1), TRHR(2)	6784654	104	26	104	88	61	19	3	9	12	0	0.614	1.000	1.000
460	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(3), AXIN1(1), AXIN2(1), BTRC(1), CAMK2B(3), CAMK2G(1), CER1(1), CHD8(2), CREBBP(3), CSNK1A1(1), CSNK1A1L(1), CSNK2B(1), CTNNB1(2), CUL1(2), DAAM2(1), DKK2(3), FZD4(1), FZD8(2), LRP5(1), LRP6(5), MAPK10(1), MAPK8(1), MAPK9(2), MMP7(2), MYC(1), NFAT5(1), NKD2(1), NLK(2), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PORCN(1), PPP2R2B(1), PPP3R2(2), PRICKLE1(1), PRICKLE2(1), PRKACA(1), PRKCA(1), PRKCG(1), PRKX(1), ROCK2(1), SENP2(1), SFRP2(1), TCF7(1), TP53(4), VANGL2(1), WIF1(1), WNT2B(1), WNT3(1), WNT7A(1)	9006767	81	26	81	39	40	6	7	19	9	0	0.524	1.000	1.000
461	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(2), BMPR2(1), BUB1(3), CDS1(2), COL4A3BP(1), CSNK2B(1), DGKA(1), DGKB(2), DGKD(2), DGKE(1), DGKG(3), DGKZ(1), IMPA1(1), INPP4A(1), INPP4B(2), ITPKA(1), NEK1(1), OCRL(1), PIK3C2A(2), PIK3C2B(1), PIK3C2G(7), PIK3CA(1), PIK3CB(5), PIK3CG(1), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PLCD1(1), PLK3(2), PRKACA(1), PRKAR1A(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(2), PRKCZ(1), PRKG1(1), RPS6KA1(3), RPS6KA2(1), RPS6KA4(1), STK11(1), VRK1(1)	6300021	74	26	73	32	39	7	5	12	11	0	0.260	1.000	1.000
462	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(2), CTCFL(3), DOT1L(3), EED(1), EHMT1(1), EZH1(1), EZH2(4), HCFC1(2), HSF4(2), JMJD6(1), KDM6A(1), MEN1(2), MLL(1), MLL2(7), MLL3(5), NSD1(1), PAXIP1(1), PPP1CA(1), PRDM9(5), PRMT1(1), SETD1A(1), SETD2(1), SETD7(1), SETDB2(1), SMYD3(1), SUV39H2(1), SUV420H1(1), SUV420H2(1), WHSC1(1), WHSC1L1(1)	6635022	55	25	52	17	33	2	2	10	8	0	0.180	1.000	1.000
463	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	126	ABLIM1(1), ABLIM3(2), ARHGEF12(1), CDC42(1), CXCR4(1), DCC(5), DPYSL5(2), EFNB3(3), EPHA1(2), EPHA3(1), EPHA4(2), EPHA6(9), EPHA7(2), EPHB1(2), EPHB2(2), EPHB3(1), EPHB4(1), EPHB6(5), FES(2), FYN(1), GNAI3(1), HRAS(1), L1CAM(1), MET(4), NCK2(2), NFAT5(1), NGEF(1), NRP1(5), NTN4(1), NTNG1(1), PAK3(2), PAK7(1), PLXNA2(4), PLXNB1(2), PLXNB3(1), PLXNC1(2), PPP3R2(2), RGS3(1), ROBO1(1), ROBO2(5), ROCK2(1), SEMA3A(2), SEMA3D(2), SEMA3E(3), SEMA3G(1), SEMA4A(2), SEMA4D(1), SEMA4G(1), SEMA5A(1), SEMA5B(1), SEMA6C(1), SEMA6D(1), SLIT1(2), SLIT2(5), SLIT3(8), SRGAP3(2), UNC5A(1), UNC5B(3), UNC5C(3), UNC5D(4)	10937759	130	25	129	72	89	12	8	10	11	0	0.427	1.000	1.000
464	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTN2(3), BAIAP2(2), CDC42(1), CDH1(2), CREBBP(3), CSNK2B(1), CTNNA2(4), CTNNA3(2), CTNNB1(2), EGFR(1), FARP2(1), FYN(1), IGF1R(1), INSR(2), LMO7(1), MET(4), NLK(2), PARD3(2), PTPRB(12), PTPRF(1), PTPRJ(4), PTPRM(1), PVRL2(1), TCF7(1), WASF1(1), WASF2(1)	6729754	57	25	57	22	33	2	3	12	7	0	0.237	1.000	1.000
465	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN2(3), ARHGAP5(1), BCAR1(1), CD99(1), CDC42(1), CDH5(3), CLDN11(1), CLDN17(1), CLDN6(1), CTNNA2(4), CTNNA3(2), CTNNB1(2), CXCR4(1), GNAI3(1), GRLF1(1), ICAM1(1), ITGA4(2), ITGB2(1), ITK(1), MAPK12(1), MAPK13(1), MMP9(1), NOX3(3), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PRKCA(1), PRKCG(1), PTK2B(1), PTPN11(1), RAPGEF3(1), RAPGEF4(2), RASSF5(1), ROCK2(1), TXK(1), VAV1(2), VAV2(1), VAV3(1), VCAM1(2)	6930331	63	25	62	27	34	4	5	8	12	0	0.122	1.000	1.000
466	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	64	ADCY1(3), ADCY8(6), ARAF(1), CACNA1C(3), CAMK2B(3), CAMK2G(1), CAMK4(2), CREBBP(3), GNAQ(2), GRIA1(7), GRIA2(4), GRIN2A(5), GRIN2B(3), GRM1(1), GRM5(2), HRAS(1), ITPR1(7), ITPR2(1), ITPR3(3), MAP2K2(1), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PPP1CA(1), PPP1R12A(1), PPP3R2(2), PRKACA(1), PRKCA(1), PRKCG(1), PRKX(1), RAPGEF3(1), RPS6KA1(3), RPS6KA2(1), RPS6KA6(1)	5388816	84	25	83	35	56	4	4	15	5	0	0.0541	1.000	1.000
467	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), ADSL(1), AK5(1), ALLC(2), AMPD1(3), ENPP1(2), ENPP3(1), ENTPD1(1), FHIT(1), GART(1), GDA(1), GMPS(2), GUCY1A2(3), GUCY1A3(5), GUCY2D(2), GUCY2F(1), NPR1(2), PDE1A(2), PDE4C(2), PDE4D(1), PDE6B(2), PDE6C(4), PDE7B(1), PDE8A(1), PDE9A(1), PFAS(1), POLE(1), POLG(1), POLQ(2), POLR1B(1), POLR2A(1), POLR2I(1), PRPS1L1(1), PRPS2(1), PRUNE(1)	7170188	70	25	68	29	53	6	2	5	4	0	0.0459	1.000	1.000
468	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(1), CD44(1), CHAD(1), COL11A1(7), COL11A2(4), COL1A1(3), COL1A2(3), COL2A1(1), COL3A1(8), COL4A1(5), COL4A2(3), COL4A4(6), COL4A6(3), COL5A1(2), COL5A2(4), COL5A3(4), COL6A1(1), COL6A3(3), COL6A6(6), DAG1(1), FN1(4), FNDC1(8), FNDC3A(2), HSPG2(2), IBSP(1), ITGA10(3), ITGA11(1), ITGA2(3), ITGA2B(1), ITGA4(2), ITGA5(5), ITGA7(2), ITGA9(1), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(1), LAMA1(5), LAMA2(3), LAMA3(6), LAMA5(2), LAMB1(1), LAMB3(4), LAMB4(3), LAMC2(1), LAMC3(1), RELN(6), SDC1(1), SV2B(1), THBS1(3), THBS2(1), THBS3(1), TNR(6), TNXB(15), VWF(2)	12558478	169	24	168	68	124	11	4	18	12	0	0.146	1.000	1.000
469	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(1), CADM3(2), CD22(4), CD6(3), CD80(1), CD86(2), CD8B(1), CD99(1), CDH1(2), CDH15(1), CDH2(1), CDH4(1), CDH5(3), CLDN11(1), CLDN17(1), CLDN6(1), CNTN2(1), CNTNAP2(6), GLG1(1), HLA-DOA(1), HLA-DRB1(1), HLA-G(1), ICAM1(1), ITGA4(2), ITGA9(1), ITGB2(1), L1CAM(1), MAG(1), MPZ(1), NCAM1(1), NCAM2(2), NEO1(3), NLGN2(1), NRCAM(1), NRXN1(3), NRXN2(2), NRXN3(3), PTPRC(3), PTPRF(1), PTPRM(1), PVRL2(1), SDC1(1), SELE(2), SELP(1), SIGLEC1(2), SPN(1), VCAM1(2), VCAN(7)	8212462	83	24	83	34	57	7	4	7	8	0	0.0553	1.000	1.000
470	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	CBL(3), CBLB(3), CBLC(1), CREBBP(3), CSF2RA(3), CSF2RB(1), CSF3(1), CSF3R(2), EPO(1), GHR(5), IFNA16(1), IFNA21(2), IFNA6(1), IL10RA(1), IL12B(1), IL12RB1(2), IL15RA(1), IL19(1), IL20RA(1), IL21R(1), IL22(1), IL22RA1(1), IL28A(1), IL29(1), IL3RA(1), IL4R(1), IL5RA(2), IL7R(6), IL9R(1), IRF9(1), JAK3(1), LEPR(3), MPL(1), MYC(1), OSM(3), OSMR(5), PIAS2(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PIM1(1), PRLR(1), PTPN11(1), SOS1(1), SOS2(2), SPRY3(1), SPRY4(1), STAT3(1), STAT5A(1), STAT6(1), TPO(5), TYK2(1)	8151102	95	24	93	35	57	5	1	18	14	0	0.0666	1.000	1.000
471	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	123	ARAF(1), CD244(1), CD48(1), FCGR3A(1), FCGR3B(1), FYN(1), HLA-G(1), HRAS(1), ICAM1(1), IFNA16(1), IFNA21(2), IFNA6(1), ITGB2(1), KIR2DL4(1), KIR3DL1(1), KLRC1(1), LCK(2), LCP2(1), MAP2K2(1), MICA(1), MICB(1), NFAT5(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PPP3R2(2), PRF1(2), PRKCA(1), PRKCG(1), PTK2B(1), PTPN11(1), SHC1(2), SHC3(1), SOS1(1), SOS2(2), SYK(2), TNFRSF10B(1), TNFRSF10D(1), TNFSF10(1), TYROBP(1), VAV1(2), VAV2(1), VAV3(1)	6181141	60	24	59	25	34	5	3	9	9	0	0.166	1.000	1.000
472	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(1), AGTR2(3), BDKRB2(1), C3AR1(1), CCKAR(1), CCKBR(2), CCR1(1), CCR2(1), CCR3(1), CCR4(1), CCR6(1), CXCR3(1), CXCR4(1), EDNRA(1), EDNRB(1), FPR1(2), FSHR(4), GALR2(1), GHSR(3), LHCGR(3), MC5R(1), NMBR(2), NPY2R(2), NPY5R(2), OPRK1(2), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(1), TACR1(1), TACR2(1), TACR3(3), TRHR(2), TSHR(3)	2934523	54	24	54	48	34	6	3	5	6	0	0.759	1.000	1.000
473	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), AKR1C1(1), AKR1C3(3), ALDH3A1(2), CYP1A2(2), CYP2C19(7), CYP2C8(1), CYP2C9(3), CYP2S1(1), CYP3A4(1), CYP3A43(1), CYP3A7(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2A1(4), UGT2B10(2), UGT2B11(3), UGT2B15(4), UGT2B28(2), UGT2B4(5), UGT2B7(4)	3199352	64	23	64	34	46	5	1	5	7	0	0.273	1.000	1.000
474	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	71	ARAF(1), CACNA1A(4), CRHR1(1), GNAI3(1), GNAQ(2), GNAS(3), GRIA1(7), GRIA2(4), GRID2(1), GRM1(1), GRM5(2), GUCY1A2(3), GUCY1A3(5), GUCY2D(2), GUCY2F(1), HRAS(1), IGF1R(1), ITPR1(7), ITPR2(1), ITPR3(3), LYN(1), MAP2K2(1), NOS1(7), NOS3(1), NPR1(2), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PPP2R2B(1), PRKCA(1), PRKCG(1), PRKG1(1), PRKG2(3), RYR1(6)	5996153	94	23	93	47	67	5	4	13	5	0	0.132	1.000	1.000
475	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	97	ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), CAMK2B(3), CAMK2G(1), CREB3L1(2), CREB3L3(1), CREBBP(3), CTNNB1(2), EDN1(1), EDNRB(1), FZD4(1), FZD8(2), GNAI3(1), GNAQ(2), GNAS(3), HRAS(1), KIT(1), KITLG(1), MAP2K2(1), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PRKACA(1), PRKCA(1), PRKCG(1), PRKX(1), TCF7(1), WNT2B(1), WNT3(1), WNT7A(1)	5992304	61	23	60	30	42	6	5	7	1	0	0.208	1.000	1.000
476	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), ADSL(1), AK5(1), ALLC(2), AMPD1(3), ENPP1(2), ENPP3(1), ENTPD1(1), ENTPD5(1), ENTPD6(1), FHIT(1), GART(1), GDA(1), GMPR2(1), GMPS(2), GUCY1A2(3), GUCY1A3(5), GUCY2D(2), GUCY2F(1), NME6(1), NPR1(2), NT5C1B(2), PDE10A(1), PDE11A(2), PDE1A(2), PDE1C(3), PDE2A(1), PDE4C(2), PDE4D(1), PDE7A(1), PDE7B(1), PDE8A(1), PDE9A(1), PFAS(1), PNPT1(1), POLA2(1), POLE(1), POLR1B(1), POLR2A(1), POLR2I(1), POLR3A(1), POLR3H(1), PRIM2(1), PRPS1L1(1), PRPS2(1), PRUNE(1), RRM2B(1), XDH(6), ZNRD1(1)	9154208	88	22	86	40	65	9	3	5	6	0	0.0813	1.000	1.000
477	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	ASCC3(1), ATP13A2(1), DDX50(1), DDX52(1), ENPP1(2), ENPP3(1), EP400(3), ERCC3(1), G6PC(2), G6PC2(3), GANC(1), GBA(2), GBE1(1), GCK(3), GUSB(1), GYS2(2), HK3(2), MGAM(9), MOV10L1(2), PGM3(3), PYGL(2), SI(10), UGP2(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2A1(4), UGT2B10(2), UGT2B11(3), UGT2B15(4), UGT2B28(2), UGT2B4(5), UGT2B7(4)	6881704	86	22	86	36	56	8	3	6	13	0	0.132	1.000	1.000
478	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	93	ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), CACNA1C(3), CACNA1D(5), CACNA1F(1), CACNA1S(2), CAMK2B(3), CAMK2G(1), CDC42(1), EGFR(1), GNAQ(2), GNAS(3), HRAS(1), ITPR1(7), ITPR2(1), ITPR3(3), MAP2K2(1), MAP2K3(2), MAP3K1(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK8(1), MAPK9(2), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PLD1(1), PLD2(2), PRKACA(1), PRKCA(1), PRKX(1), PTK2B(1), SOS1(1), SOS2(2)	7016646	87	22	85	34	52	6	7	17	5	0	0.0412	1.000	1.000
479	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	89	BCAR1(1), CAPN10(1), CAPN11(2), CAPN5(3), CAPN6(1), CAPN7(1), CAPN9(1), CAV1(1), CDC42(1), CRK(1), FYN(1), GIT2(1), ITGA10(3), ITGA11(1), ITGA2(3), ITGA2B(1), ITGA4(2), ITGA5(5), ITGA7(2), ITGA9(1), ITGAD(2), ITGAE(3), ITGAX(2), ITGB2(1), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(1), MAP2K2(1), MAP2K3(2), MAPK10(1), MAPK12(1), MAPK4(3), MYLK2(3), PAK3(2), ROCK2(1), SDCCAG8(2), SHC1(2), SHC3(1), SOS1(1), TLN1(2), VAV2(1), VAV3(1), ZYX(1)	7406042	71	22	71	34	47	1	5	11	7	0	0.246	1.000	1.000
480	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	76	ANGPTL2(1), ARHGEF7(1), BCAR1(1), CAV1(1), CDC42(1), CDKN2A(1), CRK(1), EPHB2(2), FYN(1), GRB7(1), GRLF1(1), ITGA10(3), ITGA11(1), ITGA2(3), ITGA4(2), ITGA5(5), ITGA7(2), ITGA9(1), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(1), MAPK9(2), MRAS(1), MYLK(2), MYLK2(3), P4HB(1), PAK3(2), PAK7(1), PIK3CA(1), PIK3CB(5), ROCK2(1), SHC1(2), SOS1(1), SOS2(2), TERF2IP(1), TLN1(2), TLN2(2), ZYX(1)	6690089	65	22	64	32	37	1	4	15	8	0	0.501	1.000	1.000
481	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(2), F11(3), F13B(1), F5(7), F7(2), F8(4), FGA(4), FGG(1), LPA(6), PLAT(1), PLG(3), SERPINB2(3), SERPINF2(2), VWF(2)	1971658	41	21	41	18	28	3	1	5	4	0	0.392	1.000	1.000
482	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ATM(1), BUB1(3), CCNA1(5), CCNB3(2), CCNE2(2), CDC14A(1), CDC25B(2), CDC25C(1), CDC7(1), CDH1(2), CDKN2A(1), E2F1(2), E2F3(1), HDAC3(1), HDAC5(1), MCM2(1), MCM4(2), MCM6(1), MDM2(1), MPEG1(1), MPL(1), PRKDC(2), RBL1(1), TBC1D8(1), TFDP1(1), TP53(4), WEE1(1)	6156148	43	21	42	19	20	2	4	9	8	0	0.539	1.000	1.000
483	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), ALDOB(1), BPGM(1), G6PC(2), G6PC2(3), GAPDH(2), GCK(3), HK3(2), LDHA(1), LDHAL6A(1), PDHA2(2), PFKM(1), PGK1(1), PGK2(3), PGM3(3)	3259799	39	21	39	20	25	3	1	5	5	0	0.293	1.000	1.000
484	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA12(7), ABCA13(7), ABCA3(1), ABCA4(2), ABCA5(1), ABCA6(2), ABCA7(1), ABCA8(2), ABCA9(3), ABCB1(6), ABCB11(1), ABCB4(2), ABCB5(4), ABCC11(1), ABCC12(1), ABCC2(1), ABCC3(3), ABCC6(3), ABCC8(2), ABCC9(4), ABCD2(1), ABCD3(1), ABCG1(2), ABCG2(1), ABCG4(1), ABCG8(2), CFTR(2), TAP1(1)	6607080	65	21	65	42	48	4	2	6	5	0	0.481	1.000	1.000
485	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(5), COL4A2(3), COL4A3(4), COL4A4(6), COL4A5(3), COL4A6(3), F10(2), F11(3), F2R(1), F5(7), F8(4), FGA(4), FGG(1), KLKB1(2), PROC(1), SERPINC1(1)	2490503	50	21	50	17	37	3	2	4	4	0	0.508	1.000	1.000
486	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	BFAR(1), BTK(2), CAD(3), CASP10(1), CASP8(1), CASP8AP2(2), CSNK1A1(1), DAXX(1), EGFR(1), EPHB2(2), MAP3K1(1), MAP3K5(2), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(1), MAPK9(2), MET(4), NFAT5(1), NFKB2(1), PTPN13(1), TP53(4), TPX2(2), TRAF2(1), TUFM(1)	4063144	41	21	41	19	27	3	2	4	5	0	0.381	1.000	1.000
487	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(1), CCNA1(5), CCNE2(2), CDKN2A(1), CREB3L1(2), CREB3L3(1), E2F1(2), E2F3(1), MCM2(1), MCM4(2), MCM6(1), MDM2(1), MYC(1), MYT1(2), POLA2(1), POLE(1), RBL1(1), TFDP1(1), TNXB(15), TP53(4), WEE1(1)	4399879	47	20	46	21	29	4	3	7	4	0	0.314	1.000	1.000
488	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), CEL(2), DGKA(1), DGKB(2), DGKD(2), DGKE(1), DGKG(3), DGKZ(1), LCT(3), LIPC(1), PNLIP(1), PNLIPRP2(1), PPAP2B(3)	2705565	35	20	35	20	28	3	1	2	1	0	0.397	1.000	1.000
489	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(1), ACADM(1), ACOX3(2), ACSL1(2), ACSL5(3), ACSL6(1), AQP7(1), CPT1A(1), CPT1C(2), CYP4A11(5), CYP4A22(2), CYP7A1(1), CYP8B1(1), EHHADH(1), FABP1(1), FABP5(1), FADS2(1), GK2(3), HMGCS2(1), ME1(1), MMP1(1), PPARA(1), SCP2(2), SLC27A2(2), SLC27A5(1), SLC27A6(2)	3677672	41	20	41	23	31	3	1	4	2	0	0.410	1.000	1.000
490	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	97	CASP8(1), CD80(1), CD86(2), CXCL9(1), IFNA16(1), IFNA21(2), IFNA6(1), IKBKB(1), IKBKE(3), IL12B(1), IL1B(1), IRAK1(1), IRF3(1), IRF5(1), LBP(1), MAP2K2(1), MAP2K3(2), MAPK10(1), MAPK12(1), MAPK13(1), MAPK8(1), MAPK9(2), NFKB2(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), RELA(1), TLR1(1), TLR2(2), TLR3(1), TLR4(3), TLR5(1), TLR6(1), TLR7(1), TLR8(4), TRAF6(1)	4976729	57	20	56	26	34	4	4	8	7	0	0.246	1.000	1.000
491	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	CDC42(1), CDKN2A(1), CREB5(2), ERBB4(3), IRS1(1), MET(4), MYC(1), PAK3(2), PAK7(1), PARD3(2), PARD6A(1), PIK3CA(1), PPP1R13B(2), RPS6KA1(3), RPS6KA2(1), SHC1(2), SOS1(1), SOS2(2), TSC2(1)	4291356	32	20	32	15	16	3	3	7	3	0	0.567	1.000	1.000
492	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	CABIN1(2), CAMK2B(3), CAMK4(2), CREBBP(3), CSNK2B(1), FCER1A(2), FCGR3A(1), GATA4(1), GRLF1(1), HRAS(1), IL1B(1), ITK(1), MAPK8(1), MAPK9(2), MEF2B(1), MEF2D(1), MYF5(3), NCK2(2), NFAT5(1), NFKB2(1), NUP214(2), PTPRC(3), RELA(1), TRAF2(1), TRPV6(2), VAV1(2), VAV2(1), VAV3(1)	5101653	44	19	44	19	33	4	0	6	1	0	0.241	1.000	1.000
493	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), ALDOB(1), BPGM(1), G6PC(2), GAPDH(2), GCK(3), HK3(2), LDHA(1), PDHA2(2), PFKM(1), PGK1(1), PGM3(3)	2738319	33	19	33	19	22	3	1	2	5	0	0.412	1.000	1.000
494	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), ALDOB(1), BPGM(1), G6PC(2), GAPDH(2), GCK(3), HK3(2), LDHA(1), PDHA2(2), PFKM(1), PGK1(1), PGM3(3)	2738319	33	19	33	19	22	3	1	2	5	0	0.412	1.000	1.000
495	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	ALG13(1), ALG6(1), B4GALT3(1), B4GALT5(1), CHPF(1), CHST4(2), DDOST(1), EXTL3(1), GALNT11(1), GALNT12(1), GALNT13(4), GALNT4(2), GALNT6(2), GALNT8(1), GALNTL1(1), GALNTL2(4), GCNT1(1), GCNT3(2), HS3ST1(1), HS3ST2(1), HS6ST2(1), HS6ST3(4), MAN1A1(2), MAN1A2(2), MAN1C1(1), MGAT2(1), MGAT5(1), MGAT5B(1), NDST3(2), NDST4(5), ST3GAL3(1), STT3B(2), WBSCR17(2), XYLT1(3)	6138607	58	19	58	36	37	7	4	2	8	0	0.567	1.000	1.000
496	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CLK3(2), COL2A1(1), CPSF1(1), CPSF3(1), CSTF2T(1), DHX9(1), DICER1(1), GIPC1(1), LOC440563(3), NONO(2), NXF1(1), POLR2A(1), PRPF4(1), PRPF8(2), RBM5(2), RNGTT(2), SF3A2(1), SF3B1(2), SFRS12(1), SFRS7(2), SNRPA1(1), SNRPN(1), SNURF(1), SRRM1(3), U2AF2(1)	5958269	36	19	36	21	24	2	1	5	4	0	0.911	1.000	1.000
497	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	43	ANGPTL2(1), ARHGAP4(1), ARHGEF11(2), BTK(2), CDC42(1), ITPR1(7), ITPR2(1), ITPR3(3), MYLK(2), MYLK2(3), PAK3(2), PAK7(1), PIK3CA(1), PIK3CG(1), PIK3R1(4), PPP1R13B(2), ROCK2(1), WASF1(1)	3882776	36	19	36	19	23	1	2	6	4	0	0.472	1.000	1.000
498	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ALG6(1), CCKBR(2), CCR2(1), CCR3(1), CELSR2(1), CELSR3(2), CHRM2(1), CHRM3(3), CXCR3(1), EDNRA(1), EMR2(1), F2R(1), FSHR(4), GPR116(1), GPR133(1), GPR135(1), GPR18(1), GRM1(1), LGR6(1), LPHN2(4), LPHN3(1), OR2M4(1), OR8G2(1), PTGFR(2), SMO(1), SSTR2(1), TAAR5(1), TSHR(3)	3726992	41	18	41	23	25	5	2	6	3	0	0.327	1.000	1.000
499	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	AGPAT6(1), CDS1(2), CHAT(1), DGKA(1), DGKB(2), DGKD(2), DGKE(1), DGKG(3), DGKI(3), DGKZ(1), ESCO1(1), ESCO2(1), GPD1(1), GPD1L(1), MYST3(1), MYST4(2), PCYT1B(1), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PLD1(1), PLD2(2), PPAP2B(3), PTDSS2(1)	3660070	39	18	39	20	24	3	4	6	2	0	0.545	1.000	1.000
500	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(3), ALOX15(1), ALOX15B(2), ALOX5(1), CYP2C19(7), CYP2C8(1), CYP2C9(3), CYP2J2(2), CYP4A11(5), CYP4A22(2), CYP4F3(1), GGT1(1), GPX5(1), GPX6(1), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PTGES2(1), PTGS2(1), TBXAS1(3)	2171245	43	18	43	33	33	1	0	5	4	0	0.792	1.000	1.000
501	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	ATM(1), BIRC3(1), CASP10(1), CASP7(1), CASP8(1), CSF2RB(1), IKBKB(1), IL1B(1), IL1R1(1), IL3RA(1), IRAK1(1), MAP3K14(1), NFKB2(1), NTRK1(4), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PPP3R2(2), PRKACA(1), PRKAR1A(1), RELA(1), TNFRSF10B(1), TNFRSF10D(1), TNFSF10(1), TP53(4), TRAF2(1)	4665186	42	18	41	19	19	5	2	6	10	0	0.400	1.000	1.000
502	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(2), ADCY6(1), ADCY8(6), CACNA1A(4), CACNA1B(2), GNAS(3), GRM4(1), ITPR3(3), KCNB1(6), PDE1A(2), PLCB2(1), PRKACA(1), PRKX(1), SCNN1B(1), SCNN1G(2), TAS1R2(2), TAS1R3(1), TAS2R1(2), TAS2R13(1), TAS2R16(2), TAS2R38(2), TAS2R41(3), TAS2R5(1), TAS2R60(3), TAS2R8(1), TAS2R9(1)	3173334	55	18	55	30	42	5	2	5	1	0	0.0796	1.000	1.000
503	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(1), AGT(1), CAMK1(1), CAMK1G(2), CAMK4(2), CREBBP(3), CSNK1A1(1), EDN1(1), GATA4(1), HRAS(1), MAPK8(1), MEF2C(1), MYH2(9), NKX2-5(1), PIK3CA(1), PIK3R1(4), PRKAR1A(1), SYT1(1)	2804007	33	18	33	19	20	2	2	4	5	0	0.663	1.000	1.000
504	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(3), DAG1(1), EPHB2(2), FBXW7(1), GRAP2(1), ITK(1), ITPKA(1), LCK(2), LCP2(1), NFAT5(1), NFKB2(1), PAK3(2), PAK7(1), PTPRC(3), RASGRP1(2), RASGRP2(1), RASGRP3(2), RASGRP4(1), SOS1(1), SOS2(2), VAV1(2)	3108015	32	18	32	17	19	1	2	5	5	0	0.678	1.000	1.000
505	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	G6PC(2), G6PC2(3), GALE(1), GALK2(1), GANC(1), GCK(3), HK3(2), LCT(3), MGAM(9), PFKM(1), PGM3(3), UGP2(1)	2158300	30	17	30	16	20	2	0	1	7	0	0.290	1.000	1.000
506	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	CAD(3), DPYD(5), DPYS(2), ENTPD1(1), ENTPD5(1), ENTPD6(1), NME6(1), NT5C1B(2), PNPT1(1), POLA2(1), POLE(1), POLR1B(1), POLR2A(1), POLR2I(1), POLR3A(1), POLR3H(1), PRIM2(1), RRM2B(1), TXNRD1(2), ZNRD1(1)	4540457	29	17	29	18	19	2	1	3	4	0	0.710	1.000	1.000
507	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(4), ACSL1(2), ACSL5(3), ACSL6(1), ADIPOR2(1), CAMKK2(1), CPT1A(1), CPT1C(2), G6PC(2), G6PC2(3), IKBKB(1), IRS1(1), JAK3(1), LEPR(3), MAPK10(1), MAPK8(1), MAPK9(2), NFKB2(1), PPARA(1), PPARGC1A(2), PRKAA2(2), PRKAG2(2), PRKCQ(2), PTPN11(1), RELA(1), STAT3(1), STK11(1), TRAF2(1), TYK2(1)	4646869	46	17	46	23	32	5	1	4	4	0	0.353	1.000	1.000
508	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	67	CDC42(1), HRAS(1), KDR(3), MAP2K2(1), MAPK12(1), MAPK13(1), MAPKAPK3(1), NFAT5(1), NOS3(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PPP3R2(2), PRKCA(1), PRKCG(1), PTGS2(1), VEGFA(2)	3973604	37	16	36	20	22	0	2	7	6	0	0.582	1.000	1.000
509	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), BDKRB2(1), CAV1(1), FLT4(4), KDR(3), NOS3(1), PDE2A(1), PDE3A(3), PRKAR1A(1), PRKG1(1), PRKG2(3), RYR2(6), SYT1(1), TNNI1(1)	2281103	28	16	28	15	21	1	1	1	4	0	0.383	1.000	1.000
510	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(3), DPYD(5), DPYS(2), ENTPD1(1), POLE(1), POLG(1), POLQ(2), POLR1B(1), POLR2A(1), POLR2I(1), TXNRD1(2)	3212623	20	16	20	11	12	1	1	4	2	0	0.625	1.000	1.000
511	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CHN1(1), MAP3K1(1), MYLK(2), PDGFRA(5), PIK3CA(1), PIK3R1(4), PLD1(1), TRIO(1), VAV1(2), WASF1(1)	1967278	19	16	19	11	9	2	3	2	3	0	0.690	1.000	1.000
512	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(1), ANGPTL2(1), CDC42(1), FLNC(4), MYH2(9), MYLK(2), MYLK2(3), PAK3(2), PAK7(1), ROCK2(1), WASF1(1)	2678150	26	16	26	21	20	2	0	3	1	0	0.840	1.000	1.000
513	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	36	AGT(1), AGTR2(3), CAMK2B(3), CAMK2G(1), FYN(1), HRAS(1), MAP2K2(1), MAPK8(1), MAPT(2), MYLK(2), PRKCA(1), PTK2B(1), SHC1(2), SOS1(1), STAT3(1), STAT5A(1), SYT1(1)	2284308	24	15	23	14	18	2	1	2	1	0	0.532	1.000	1.000
514	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(2), F2R(1), F3(2), F5(7), F7(2), FGA(4), FGG(1), PROC(1), SERPINC1(1), TFPI(2)	920149	23	15	23	12	14	1	1	5	2	0	0.748	1.000	1.000
515	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	BTK(2), FCER1A(2), HRAS(1), LYN(1), MAP3K1(1), MAPK8(1), PIK3CA(1), PIK3R1(4), SHC1(2), SOS1(1), SYK(2), SYT1(1), VAV1(2)	2365551	21	15	21	11	11	1	2	4	3	0	0.705	1.000	1.000
516	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CAMK1(1), CAMK1G(2), FPR1(2), HRAS(1), MAP2K2(1), MAP2K3(2), MAP3K1(1), PIK3C2G(7), PLCB1(4), RELA(1), SYT1(1)	2092684	23	15	23	14	13	2	3	2	3	0	0.769	1.000	1.000
517	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	G6PC(2), GALE(1), GALK2(1), GCK(3), HK3(2), LCT(3), MGAM(9), PFKM(1), PGM3(3)	1820427	25	15	25	13	18	2	0	1	4	0	0.278	1.000	1.000
518	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	AGPS(2), CDS1(2), CHAT(1), DGKA(1), DGKB(2), DGKD(2), DGKE(1), DGKG(3), DGKZ(1), GPD1(1), PCYT1B(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PLCB2(1), PPAP2B(3)	2799984	27	15	27	19	18	3	1	4	1	0	0.772	1.000	1.000
519	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(1), ALOX5(1), CYP1A2(2), CYP2C19(7), CYP2C8(1), CYP2C9(3), CYP2J2(2), CYP3A4(1), CYP3A43(1), CYP3A7(3), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2)	1338677	29	15	29	22	20	2	0	5	2	0	0.829	1.000	1.000
520	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	CREBBP(3), EHHADH(1), FABP1(1), ME1(1), MYC(1), NCOA1(1), NCOR1(1), NCOR2(2), NRIP1(1), PIK3CA(1), PIK3R1(4), PPARA(1), PRKAR1A(1), PRKCA(1), PTGS2(1), RELA(1), STAT5A(1)	3548666	23	15	23	13	11	0	1	6	5	0	0.845	1.000	1.000
521	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ABP1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), AOC2(1), AOX1(3), ASMT(1), CAT(1), CYP19A1(2), CYP1A2(2), CYP2A13(1), CYP2A6(1), CYP2C19(7), CYP2C8(1), CYP2C9(3), CYP2D6(1), CYP2J2(2), CYP3A4(1), CYP3A7(3), CYP4B1(1), EHHADH(1), MAOA(1), TPH1(4)	3080018	45	15	45	30	34	2	1	4	4	0	0.630	1.000	1.000
522	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(3), AXIN1(1), CTNNB1(2), FZD8(2), LDLR(2), MAPK10(1), MAPK9(2), MYC(1), PPP2R5C(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(2), PRKCZ(1), TCF7(1), WNT2B(1), WNT3(1), WNT7A(1)	3349047	25	15	25	16	17	2	3	3	0	0	0.709	1.000	1.000
523	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(1), ATR(5), CDC25B(2), CDC25C(1), MDM2(1), MYT1(2), PRKDC(2), RPS6KA1(3), TP53(4), WEE1(1)	2358795	22	14	22	10	7	3	2	5	5	0	0.764	1.000	1.000
524	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACPT(1), ALPI(1), ALPP(2), ALPPL2(1), CYP19A1(2), CYP1A2(2), CYP2A13(1), CYP2A6(1), CYP2C19(7), CYP2C8(1), CYP2C9(3), CYP2D6(1), CYP2J2(2), CYP3A4(1), CYP3A7(3), CYP4B1(1), PON1(1)	1635328	31	14	31	29	19	2	2	5	3	0	0.952	1.000	1.000
525	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(1), G6PC(2), GAPDH(2), GCK(3), GOT2(2), HK3(2), LDHA(1), PC(1), PDHA2(2), PFKM(1), PGK1(1), PGK2(3)	2381229	21	14	21	13	12	3	0	2	4	0	0.548	1.000	1.000
526	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	CABIN1(2), CAMK1(1), CAMK1G(2), HDAC5(1), IGF1R(1), INSR(2), MEF2B(1), MEF2C(1), MEF2D(1), PIK3CA(1), PIK3R1(4), SYT1(1)	1954000	18	14	18	11	9	0	1	3	5	0	0.674	1.000	1.000
527	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(2), ACSM1(2), ALDH1B1(1), ALDH3A1(2), ALDH5A1(1), ALDH7A1(1), ALDH9A1(1), DDHD1(1), EHHADH(1), GAD1(2), GAD2(3), HMGCS2(1), OXCT1(1), OXCT2(1), PDHA2(2)	2276648	22	14	22	12	15	1	0	5	1	0	0.546	1.000	1.000
528	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(3), ALOX15(1), ALOX5(1), CYP4F3(1), GGT1(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PTGES2(1), PTGS2(1), TBXAS1(3), TPO(5)	1560520	23	14	22	17	19	0	0	2	2	0	0.685	1.000	1.000
529	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	BAG4(1), BIRC3(1), CASP7(1), CASP8(1), DAXX(1), LMNA(1), MAP3K1(1), MAP3K14(1), MAP3K5(2), MAPK8(1), MDM2(1), PRKDC(2), RELA(1), SPTAN1(1), TRAF2(1)	3878429	17	13	17	10	11	3	0	1	2	0	0.697	1.000	1.000
530	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	FYN(1), HRAS(1), LCK(2), MAP3K1(1), MAPK8(1), PIK3CA(1), PIK3R1(4), PRKCA(1), PTPN7(1), RELA(1), SHC1(2), SOS1(1), SYT1(1), VAV1(2)	2632686	20	13	20	10	10	1	3	2	4	0	0.612	1.000	1.000
531	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(1), AGT(1), AGTR2(3), EDN1(1), EDNRA(1), EDNRB(1), EGF(1), EGFR(1), HRAS(1), MYC(1), PRKCA(1), RELA(1)	1149062	14	12	14	9	10	1	2	1	0	0	0.763	1.000	1.000
532	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(1), GALNT11(1), GALNT12(1), GALNT13(4), GALNT4(2), GALNT6(2), GALNT8(1), GALNTL1(1), GALNTL2(4), GCNT1(1), GCNT3(2), WBSCR17(2)	1810144	22	12	22	15	15	2	2	0	3	0	0.764	1.000	1.000
533	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ATP6V0A2(1), ATP6V0A4(1), ATP6V1B2(1), ATP6V1C2(1), CDC42(1), EGFR(1), IGSF5(1), IKBKB(1), LYN(1), MAP3K14(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK8(1), MAPK9(2), MET(4), NFKB2(1), PTPN11(1), PTPRZ1(2), RELA(1)	3939925	25	12	25	13	12	4	2	6	1	0	0.637	1.000	1.000
534	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP4(1), ARHGAP5(1), ARHGEF11(2), ARHGEF5(2), ARPC1A(1), BAIAP2(2), MYLK(2), PIP5K1B(2), TLN1(2)	2527146	15	12	15	14	12	1	0	1	1	0	0.890	1.000	1.000
535	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(1), CDR1(3), DGKI(3), RPLP2(1), RPS27A(2), RPS4Y1(1), RPS5(1), RPS6KA1(3), RPS6KA2(1), RPS6KA6(1), RPSA(1), SLC36A2(1), TSPAN9(1)	2919511	20	12	20	12	13	2	2	2	1	0	0.704	1.000	1.000
536	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	IKBKB(1), IRAK1(1), MAP2K3(2), MAP3K1(1), MAP3K14(1), MAPK8(1), PPARA(1), RELA(1), TLR10(1), TLR2(2), TLR3(1), TLR4(3), TLR6(1), TLR7(1), TRAF6(1)	2035812	19	12	19	13	9	5	2	2	1	0	0.805	1.000	1.000
537	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(1), FYN(1), HRAS(1), MYLK(2), PIK3CA(1), PIK3R1(4), SHC1(2), TLN1(2)	2049238	14	11	14	11	7	0	2	1	4	0	0.876	1.000	1.000
538	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	GAL3ST1(1), GALC(1), GBA(2), LCT(3), PPAP2B(3), SGPP2(1), SMPD2(1), SMPD3(1), SMPD4(2), UGCG(1)	1989752	16	11	16	10	11	1	0	3	1	0	0.670	1.000	1.000
539	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(1), CAMK1G(2), CAMK2B(3), CAMK2G(1), CAMK4(2), ESRRA(1), HDAC5(1), MEF2B(1), MEF2C(1), MEF2D(1), PPARA(1), SYT1(1)	1126221	16	11	16	11	11	1	0	2	2	0	0.723	1.000	1.000
540	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(1), AGT(1), AGTR1(1), AGTR2(3), BDKRB2(1), KNG1(3), NOS3(1)	555110	11	10	11	9	11	0	0	0	0	0	0.607	1.000	1.000
541	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BLNK(2), BTK(2), HRAS(1), LYN(1), MAP3K1(1), MAPK8(1), PRKCA(1), SHC1(2), SOS1(1), SYK(2), SYT1(1), VAV1(2)	2099406	17	10	17	9	13	1	1	2	0	0	0.597	1.000	1.000
542	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC7(1), MCM2(1), MCM4(2), MCM6(1), POLA2(1), POLE(1), RFC1(2), RFC2(1), RPS27A(2)	2840049	12	10	11	11	8	0	1	2	1	0	0.958	1.000	1.000
543	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), DHRS2(1), ESCO1(1), ESCO2(1), MYST3(1), MYST4(2)	1403236	14	10	14	9	11	0	2	1	0	0	0.765	1.000	1.000
544	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPP(2), ALPPL2(1), ASCC3(1), ATP13A2(1), DDX50(1), DDX52(1), EP400(3), ERCC3(1), MOV10L1(2)	3499159	14	10	14	17	9	2	0	1	2	0	0.995	1.000	1.000
545	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), B3GALT1(1), B3GNT4(1), B4GALT3(1), FUT3(2), FUT9(3), PIGA(1), PIGN(1), PIGO(1), PIGU(1), ST3GAL3(1), ST6GALNAC3(1), UGCG(1)	2711168	16	10	16	13	8	1	1	4	2	0	0.887	1.000	1.000
546	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(1), GNAQ(2), MYLK(2), PLCB1(4), PRKCA(1)	1164656	10	10	10	10	6	0	1	3	0	0	0.963	1.000	1.000
547	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(2), GRIN2A(5), GRIN2B(3), NOS1(7), PRKAR1A(1), PRKCA(1), SYT1(1)	1431022	20	10	20	13	15	1	1	1	2	0	0.579	1.000	1.000
548	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(1), ACO2(1), IDH1(3), OGDHL(5), PC(1), SDHA(2), SDHC(1)	1681237	14	9	13	9	9	4	0	1	0	0	0.641	1.000	1.000
549	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(1), CARS(1), EPRS(2), FARS2(1), IARS2(1), KARS(2), LARS2(1), RARS(1)	3063253	11	9	11	13	9	0	1	1	0	0	0.983	1.000	1.000
550	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(1), PC(1), PDHA2(2), PDK4(1), PDP2(1), SDHA(2), SDHC(1)	1595189	9	9	9	9	6	2	0	1	0	0	0.928	1.000	1.000
551	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(1), CAMK1G(2), CAMK2B(3), CAMK2G(1), CAMK4(2), CAMKK2(1), SYT1(1)	651215	11	8	11	8	8	1	0	2	0	0	0.753	1.000	1.000
552	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(1), CD33(1), CD5(1), IL12B(1), ITGAX(2), TLR2(2), TLR4(3), TLR7(1)	1043040	12	8	12	10	7	2	2	1	0	0	0.763	1.000	1.000
553	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(2), AMT(1), AOC2(1), BHMT(1), CBS(1), GCAT(1), GLDC(1), MAOA(1), PLCB2(1), SARDH(1), SHMT2(1)	2357609	12	8	12	12	5	3	1	2	1	0	0.937	1.000	1.000
554	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(2), AMT(1), AOC2(1), BHMT(1), CBS(1), GCAT(1), GLDC(1), MAOA(1), SARDH(1), SHMT2(1)	2395548	11	8	11	13	5	2	1	2	1	0	0.974	1.000	1.000
555	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG5(1), BECN1(1), IFNA16(1), IFNA21(2), IFNA6(1), PIK3R4(1), PRKAA2(2), ULK1(1), ULK2(1)	1179022	11	8	11	7	9	1	0	1	0	0	0.728	1.000	1.000
556	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(1), ADCY3(1), ARL4D(1), ATP6V0A2(1), ATP6V0A4(1), ATP6V1C2(1), GNAS(3), PRKCA(1), SEC61A2(1)	2077242	11	8	11	9	8	1	0	2	0	0	0.812	1.000	1.000
557	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(1), EPRS(2), FARS2(1), KARS(2), LARS2(1), RARS(1)	1807235	9	7	9	9	7	0	1	1	0	0	0.949	1.000	1.000
558	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO2(1), IDH1(3), PC(1), SDHA(2)	1161077	7	7	6	5	5	2	0	0	0	0	0.731	1.000	1.000
559	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(3), ENPP1(2), ENPP3(1), NT5C1B(2)	1205341	8	7	8	5	5	2	1	0	0	0	0.692	1.000	1.000
560	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	FUCA1(1), GBA(2), GUSB(1), HEXA(2), LCT(3), SPAM1(3)	1916185	12	7	12	8	11	0	0	1	0	0	0.662	1.000	1.000
561	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	CPT1A(1), LEPR(3), PRKAA2(2), PRKAG2(2)	816866	8	7	8	6	7	1	0	0	0	0	0.817	1.000	1.000
562	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(3), AXIN1(1), CREBBP(3), CTNNB1(2)	1863996	9	7	9	6	6	0	1	2	0	0	0.827	1.000	1.000
563	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(2), PLCB1(4), PRKCA(1), RELA(1)	459458	8	7	8	5	4	0	1	3	0	0	0.841	1.000	1.000
564	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNAQ(2), HTR2C(2), PLCB1(4)	400712	8	7	8	6	3	1	1	3	0	0	0.844	1.000	1.000
565	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1)	317238	8	6	8	5	8	0	0	0	0	0	0.631	1.000	1.000
566	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CXCR4(1), GNAQ(2), MAPK8(1), PRKCA(1), PTK2B(1), SYT1(1)	773956	7	6	7	5	4	1	0	2	0	0	0.742	1.000	1.000
567	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	14	CUZD1(1), HRAS(1), MYC(1), PLCB1(4), PRKCA(1), RELA(1)	828273	9	6	9	8	5	0	1	3	0	0	0.925	1.000	1.000
568	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	ALDOB(1), GMPPA(1), HK3(2), MTMR2(1), PFKFB2(1), PFKM(1), PGM2(1)	2071571	8	6	8	10	6	0	0	1	1	0	0.927	1.000	1.000
569	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	BHMT(1), CBS(1), DNMT1(1), DNMT3A(1), DNMT3B(1), MAT2B(1), MTR(1)	1171907	7	6	7	5	5	0	0	2	0	0	0.775	1.000	1.000
570	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(1), ACE2(1), AGT(1), AGTR1(1), AGTR2(3), ANPEP(1), CMA1(1), ENPEP(1), MAS1(1), MME(2), NLN(1)	1184910	14	6	14	13	11	0	1	0	2	0	0.890	1.000	1.000
571	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CXCR3(1), IL12B(1), IL12RB1(2), MAPK8(1), TYK2(1)	1041985	6	6	6	6	5	1	0	0	0	0	0.904	1.000	1.000
572	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	BHMT(1), CBS(1), DNMT1(1), DNMT3A(1), DNMT3B(1), MAT2B(1), MTR(1)	984552	7	6	7	5	5	0	0	2	0	0	0.768	1.000	1.000
573	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACB(4), OLAH(2)	880349	6	5	6	5	5	1	0	0	0	0	0.718	1.000	1.000
574	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GUSB(1), HEXA(2), LCT(3), SPAM1(3)	1141775	9	5	9	6	9	0	0	0	0	0	0.644	1.000	1.000
575	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), BNIP1(1), STX11(1), STX17(1), STX6(1)	933537	5	5	5	5	3	1	1	0	0	0	0.920	1.000	1.000
576	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CXCR3(1), IL12B(1), IL12RB1(2), TYK2(1)	818134	5	5	5	5	4	1	0	0	0	0	0.877	1.000	1.000
577	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC3(1), CASP8(1), NFKB2(1), TRAF2(1)	1516759	5	5	5	4	5	0	0	0	0	0	0.810	1.000	1.000
578	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	GNAQ(2), PRKCA(1), SYT1(1)	1174535	4	4	4	9	2	0	0	2	0	0	0.999	1.000	1.000
579	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	FUCA1(1), HEXA(2), LCT(3)	1136452	6	4	6	5	6	0	0	0	0	0	0.771	1.000	1.000
580	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	HEXA(2), LCT(3), ST6GALNAC3(1)	923311	6	4	6	5	5	0	0	1	0	0	0.790	1.000	1.000
581	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	AMT(1), FTCD(1), GART(1), MTR(1), SHMT2(1)	1062376	5	4	5	4	2	2	0	1	0	0	0.903	1.000	1.000
582	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CSF1(1), CSF3(1), HLA-DRB1(1), IL12B(1)	740567	4	4	4	4	4	0	0	0	0	0	0.742	1.000	1.000
583	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(2), MEF2D(1), PRKCA(1), SYT1(1)	1374164	5	4	5	10	5	0	0	0	0	0	0.998	1.000	1.000
584	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	FUCA1(1), HEXA(2), LCT(3)	921713	6	4	6	5	6	0	0	0	0	0	0.795	1.000	1.000
585	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	AMT(1), GART(1), MTR(1), SHMT2(1)	1004373	4	4	4	4	1	2	0	1	0	0	0.953	1.000	1.000
586	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(2), CSNK1A1(1), MAPT(2)	508649	5	4	4	4	3	0	1	1	0	0	0.861	1.000	1.000
587	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	DNMT1(1), PTGFR(2), PTGIR(1)	624894	4	4	4	6	3	0	0	1	0	0	0.916	1.000	1.000
588	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF3(1), EPO(1), KITLG(1)	462933	3	3	3	6	3	0	0	0	0	0	0.974	1.000	1.000
589	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS2(1), PON1(1), PON3(1)	506352	3	3	3	3	2	0	1	0	0	0	0.821	1.000	1.000
590	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), GOT2(2), PAH(1)	488976	4	3	4	4	3	0	0	1	0	0	0.920	1.000	1.000
591	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(1), SDHA(2)	530707	3	3	3	4	2	1	0	0	0	0	0.903	1.000	1.000
592	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	FARS2(1), GOT2(2), PAH(1)	468513	4	3	4	4	3	0	0	1	0	0	0.896	1.000	1.000
593	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(1), GGT1(1), MAT2B(1)	699564	3	3	3	3	2	0	0	1	0	0	0.856	1.000	1.000
594	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CSF1(1), CSF3(1), EPO(1)	339972	3	3	3	4	3	0	0	0	0	0	0.835	1.000	1.000
595	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), PTGS2(1)	301591	3	2	3	4	3	0	0	0	0	0	0.883	1.000	1.000
596	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	EPO(1), RELA(1)	704639	2	2	2	4	2	0	0	0	0	0	0.984	1.000	1.000
597	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CSF3(1), KITLG(1)	344695	2	2	2	3	2	0	0	0	0	0	0.902	1.000	1.000
598	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2B(2)	334227	2	2	2	3	2	0	0	0	0	0	0.772	1.000	1.000
599	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	EHHADH(1)	271197	1	1	1	2	1	0	0	0	0	0	0.934	1.000	1.000
600	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(1)	476178	1	1	1	2	0	0	1	0	0	0	0.962	1.000	1.000
601	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP7(1)	500260	1	1	1	2	1	0	0	0	0	0	0.963	1.000	1.000
602	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	EHHADH(1)	664603	1	1	1	3	1	0	0	0	0	0	0.984	1.000	1.000
603	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	TYK2(1)	605765	1	1	1	3	0	1	0	0	0	0	0.983	1.000	1.000
604	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	PRKCA(1), PTK2B(1)	377901	2	1	2	3	1	1	0	0	0	0	0.885	1.000	1.000
605	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	MTA3(1)	602382	1	1	1	2	1	0	0	0	0	0	0.915	1.000	1.000
606	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8		318260	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
607	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4		254854	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
608	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		40470	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
609	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7		269329	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
610	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		28800	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
611	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3		125914	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
612	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2		119079	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
613	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6		458643	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
614	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6		179980	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
615	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3		63601	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7		327364	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
