		Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
BRAF	140 (53%)	124	0.035979	1	0.055172	1	0.6685	1	0.89834	1	0.043213	1	0.073025	1	0.70495	1	0.2515	1
C15ORF23	14 (5%)	250	0.9119	1	0.32125	1	1	1	0.59614	1	0.71773	1	0.61086	1	0.57436	1	0.5768	1
CDKN2A	34 (13%)	230	0.43712	1	0.31103	1	1	1	0.54441	1	0.63862	1	0.7137	1	0.50666	1	1	1
NRAS	73 (28%)	191	0.098058	1	0.20067	1	0.49853	1	0.070235	1	0.55335	1	0.8109	1	0.81227	1	0.88745	1
OXA1L	8 (3%)	256	0.61835	1	0.20117	1	1	1	0.56259	1	0.29581	1	0.38677	1	0.38421	1	0.71423	1
STK19	11 (4%)	253	0.86509	1	0.12978	1	0.87767	1	1	1	0.14836	1	0.28261	1	0.79216	1	0.54011	1
TP53	39 (15%)	225	0.32786	1	0.054178	1	0.26294	1	0.36365	1	0.022033	1	0.20448	1	0.9039	1	0.1072	1
TTN	204 (77%)	60	0.91773	1	0.0077772	1	0.17941	1	0.15461	1	0.36457	1	0.33213	1	0.023493	1	0.22303	1
UGT2B15	24 (9%)	240	0.093603	1	0.38042	1	0.3423	1	0.6095	1	0.38392	1	1	1	0.3132	1	1	1
PTEN	23 (9%)	241	0.81417	1	0.28831	1	0.010724	1	0.39415	1	0.41654	1	0.32879	1	0.92404	1	0.65491	1
RAC1	17 (6%)	247	0.29448	1	0.8586	1	0.70408	1	0.91731	1	0.23786	1	0.62973	1	0.33309	1	0.076958	1
PPP6C	23 (9%)	241	0.27892	1	0.64614	1	0.76764	1	0.11609	1	0.47543	1	0.24715	1	0.086688	1	0.072335	1
PRB2	39 (15%)	225	0.34939	1	1	1	1	1	0.91555	1	0.032978	1	0.28782	1	0.65156	1	0.21127	1
IDH1	15 (6%)	249	0.036175	1	0.34494	1	0.56287	1	0.8305	1	0.27976	1	0.30237	1	0.39211	1	0.7895	1
NAP1L2	26 (10%)	238	0.15077	1	0.96557	1	0.74885	1	0.70454	1	0.70938	1	0.70206	1	0.93186	1	1	1
FIGLA	4 (2%)	260	0.65549	1	0.36708	1	NA	NA	NA	NA	0.35902	1	0.37734	1	0.37251	1	0.30106	1
RBM11	16 (6%)	248	0.30716	1	0.026656	1	0.79213	1	0.85295	1	0.39886	1	0.023745	1	0.068028	1	0.42619	1
HBG2	9 (3%)	255	0.53673	1	0.19524	1	0.44726	1	0.44419	1	0.3827	1	0.43109	1	0.1038	1	0.30874	1
LCE1B	12 (5%)	252	0.081147	1	0.65072	1	0.91958	1	0.91731	1	0.45027	1	0.75675	1	0.93003	1	1	1
MUC7	19 (7%)	245	0.80639	1	0.44608	1	0.37601	1	0.49532	1	0.39887	1	0.64268	1	0.40246	1	0.048277	1
DDX3X	20 (8%)	244	0.95457	1	0.44048	1	0.53615	1	0.27826	1	0.1304	1	0.40745	1	0.87384	1	1	1
CDH9	37 (14%)	227	0.82355	1	0.060664	1	0.6422	1	0.88897	1	0.763	1	0.6984	1	0.0091006	1	0.19808	1
HIST1H2AA	10 (4%)	254	0.80359	1	0.71104	1	0.65874	1	0.57351	1	0.10527	1	0.84748	1	0.29786	1	0.74604	1
GFRAL	33 (12%)	231	0.76256	1	0.40491	1	0.60899	1	0.76088	1	0.12405	1	0.77118	1	0.66397	1	0.24979	1
TBC1D3B	6 (2%)	258	0.097465	1	0.66114	1	0.48038	1	0.084183	1	0.029784	1	0.85816	1	0.57812	1	1	1
HHLA2	18 (7%)	246	0.22901	1	0.7096	1	0.2837	1	0.011699	1	0.38746	1	0.26668	1	0.00070522	0.611	0.13482	1
COPG2	10 (4%)	254	0.97239	1	0.77651	1	0.20158	1	0.28303	1	0.89288	1	0.84748	1	0.29786	1	0.74604	1
FGF16	8 (3%)	256	0.67727	1	0.53411	1	0.012799	1	0.027857	1	0.10996	1	0.33991	1	0.27254	1	1	1
IL32	10 (4%)	254	0.74722	1	0.053827	1	1	1	0.14038	1	0.89288	1	0.46716	1	0.65504	1	1	1
PRB4	19 (7%)	245	0.86775	1	0.51515	1	0.030269	1	0.072937	1	0.10082	1	0.040866	1	0.29083	1	0.085709	1
NBPF7	16 (6%)	248	0.050207	1	0.20778	1	0.86121	1	1	1	0.44859	1	0.9435	1	0.15763	1	1	1
POM121	18 (7%)	246	1	1	0.25521	1	0.72997	1	0.78543	1	0.82876	1	0.58127	1	0.24502	1	0.45392	1
ARID2	38 (14%)	226	0.28991	1	0.42567	1	0.67897	1	0.026646	1	0.073387	1	1	1	0.36309	1	0.37266	1
MAP2K1	13 (5%)	251	0.85932	1	0.58704	1	0.002344	1	0.023687	1	0.20472	1	0.1715	1	0.8772	1	1	1
DEFB118	10 (4%)	254	0.80359	1	0.097812	1	1	1	1	1	0.89288	1	0.46716	1	1	1	0.74604	1
HBD	10 (4%)	254	0.91835	1	0.84711	1	0.88601	1	0.14038	1	0.28162	1	0.037849	1	0.9219	1	0.74604	1
ANKRD20A4	5 (2%)	259	0.18932	1	0.45236	1	0.20081	1	0.27791	1	0.047115	1	0.18021	1	0.52784	1	1	1
GLRB	26 (10%)	238	0.76523	1	0.45483	1	0.10813	1	0.024209	1	0.36265	1	0.56658	1	0.3521	1	0.13538	1
NR1H4	14 (5%)	250	0.98163	1	0.15238	1	0.22791	1	0.47066	1	0.74331	1	0.87686	1	0.81898	1	0.25273	1
OR51S1	30 (11%)	234	0.10543	1	0.93953	1	0.74209	1	0.038987	1	0.23328	1	0.16303	1	0.93939	1	1	1
TFEC	16 (6%)	248	0.34986	1	0.43851	1	0.083606	1	0.24698	1	0.59563	1	0.9435	1	0.80721	1	1	1
UNC119B	6 (2%)	258	0.14021	1	0.44691	1	0.42437	1	0.66793	1	0.80491	1	0.15344	1	1	1	0.67729	1
ZNF479	27 (10%)	237	0.53216	1	0.84154	1	0.27901	1	0.34765	1	0.8914	1	0.48542	1	0.15659	1	0.67418	1
FAM19A1	10 (4%)	254	0.056021	1	0.60473	1	0.17254	1	0.013259	1	0.074394	1	1	1	0.84663	1	0.51265	1
GIMAP7	24 (9%)	240	0.0015335	1	0.48322	1	0.1815	1	0.23868	1	0.23815	1	0.79024	1	0.52127	1	0.27029	1
KLHL4	23 (9%)	241	0.69306	1	0.38255	1	0.93994	1	0.73332	1	0.63315	1	0.063956	1	0.53749	1	0.49644	1
NOTCH2NL	13 (5%)	251	0.6947	1	0.34247	1	0.37413	1	0.066896	1	0.016991	1	0.0056382	1	0.32014	1	0.085883	1
PRC1	15 (6%)	249	0.29539	1	0.36656	1	0.25671	1	0.37779	1	0.36761	1	0.62534	1	0.21388	1	0.42089	1
ZMAT4	10 (4%)	254	0.3248	1	0.078288	1	0.7027	1	0.24861	1	0.94389	1	0.84748	1	0.38516	1	0.51265	1
PDE1A	34 (13%)	230	0.83128	1	0.9453	1	0.66265	1	0.39959	1	0.056979	1	0.20753	1	0.45299	1	0.34431	1
GML	10 (4%)	254	0.84371	1	0.42869	1	0.20158	1	0.32649	1	0.60435	1	0.46716	1	0.12393	1	1	1
OR4N2	25 (9%)	239	0.3179	1	0.3023	1	0.36353	1	0.44537	1	0.0023067	1	0.098639	1	0.57379	1	0.053554	1
ACSM2B	40 (15%)	224	0.37793	1	0.5797	1	0.69	1	0.719	1	0.31358	1	0.33564	1	0.22915	1	0.4822	1
USP17L2	19 (7%)	245	0.26475	1	0.04887	1	0.24216	1	0.45007	1	0.0051397	1	0.23918	1	0.33395	1	0.46401	1
TAF1A	13 (5%)	251	0.47947	1	0.87611	1	0.67011	1	0.78543	1	0.78342	1	0.44484	1	0.81898	1	0.77153	1
OR5H2	19 (7%)	245	0.34236	1	0.75484	1	0.79213	1	0.66571	1	0.82876	1	0.74504	1	0.75375	1	1	1
PHGDH	9 (3%)	255	0.93638	1	0.91088	1	0.79009	1	0.48257	1	0.39375	1	0.35759	1	0.91018	1	0.30874	1
BAGE2	14 (5%)	250	1	1	1	1	1	1	0.90415	1	0.5784	1	0.81952	1	0.40998	1	0.78019	1
FUT9	25 (9%)	239	0.63869	1	0.0056769	1	0.46962	1	0.32777	1	0.27269	1	0.56244	1	0.32642	1	0.83209	1
MPP7	29 (11%)	235	0.38829	1	0.74646	1	0.9178	1	0.74198	1	0.11957	1	0.49682	1	0.74098	1	1	1
TSPAN9	4 (2%)	260	0.47309	1	1	1	0.1638	1	0.60607	1	0.83428	1	0.57201	1	0.68562	1	1	1
TRAT1	13 (5%)	251	0.53165	1	0.2563	1	0.49675	1	0.7654	1	0.18274	1	0.45671	1	0.63023	1	0.77153	1
C9ORF119	8 (3%)	256	0.67727	1	0.66805	1	0.61685	1	0.60607	1	0.38516	1	1	1	0.27254	1	0.26602	1
TUBB8	15 (6%)	249	0.29218	1	0.74722	1	0.41078	1	0.65089	1	0.83895	1	0.94108	1	0.52723	1	0.42089	1
ACD	10 (4%)	254	0.91835	1	0.42869	1	0.65674	1	0.23856	1	0.66023	1	0.38848	1	0.17085	1	0.18788	1
NUDT4	5 (2%)	259	0.13427	1	0.37271	1	0.21836	1	0.040932	1	1	1	0.61651	1	0.22352	1	0.373	1
C8A	30 (11%)	234	0.21456	1	0.20181	1	0.26761	1	0.067287	1	0.029298	1	0.28855	1	0.60452	1	0.32363	1
KIAA1257	15 (6%)	249	0.91962	1	0.74722	1	0.67011	1	0.28219	1	0.80168	1	0.47186	1	0.70693	1	0.42089	1
SNAP91	28 (11%)	236	0.31256	1	0.87581	1	0.17639	1	0.46909	1	0.86057	1	1	1	0.27455	1	0.29784	1
CCK	7 (3%)	257	1	1	0.70306	1	0.041483	1	0.15999	1	0.60854	1	0.8016	1	0.37911	1	0.71174	1
SPINK13	9 (3%)	255	0.15269	1	0.57491	1	0.62115	1	0.6124	1	0.068317	1	0.11671	1	0.20271	1	0.73504	1
ANXA10	14 (5%)	250	0.19844	1	0.014546	1	0.25766	1	0.44999	1	0.097698	1	0.027561	1	0.34344	1	0.16086	1
LIN7A	11 (4%)	253	0.41603	1	0.17939	1	0.20158	1	0.28303	1	0.027788	1	0.11726	1	0.39005	1	0.54011	1
C2	14 (5%)	250	0.15136	1	0.41363	1	0.91071	1	0.8305	1	0.0037429	1	0.11683	1	0.29878	1	0.77153	1
DGAT2L6	12 (5%)	252	0.3452	1	0.60352	1	0.61851	1	0.34335	1	0.74719	1	0.93044	1	0.8134	1	1	1
RAPGEF5	13 (5%)	251	0.33929	1	0.62762	1	0.7027	1	0.54051	1	0.070187	1	0.76731	1	0.17728	1	0.25273	1
OR2L3	17 (6%)	247	0.884	1	0.063734	1	0.41032	1	0.52668	1	0.76028	1	0.5965	1	0.90249	1	0.44885	1
ZNF679	20 (8%)	244	0.51173	1	0.51062	1	0.73622	1	0.65295	1	0.14563	1	0.80165	1	0.15871	1	0.48315	1
NAP1L4	10 (4%)	254	0.058702	1	0.029481	1	0.87767	1	0.43066	1	0.12991	1	0.12357	1	0.9219	1	0.51265	1
PARM1	18 (7%)	246	0.027564	1	1	1	0.81411	1	0.21991	1	0.92379	1	0.86207	1	0.1776	1	0.045801	1
DEFB119	6 (2%)	258	0.53149	1	0.76827	1	0.8122	1	0.81851	1	0.94639	1	1	1	0.33604	1	1	1
RGS18	10 (4%)	254	0.36883	1	0.22293	1	0.21836	1	0.15999	1	0.39375	1	1	1	0.32309	1	1	1
VEGFC	17 (6%)	247	0.058783	1	0.40833	1	1	1	0.27272	1	0.29532	1	0.048894	1	0.18928	1	0.11872	1
ARL16	7 (3%)	257	0.68668	1	0.79607	1	0.15924	1	0.68437	1	0.51912	1	0.18133	1	1	1	1	1
CACNA1H	24 (9%)	240	0.4358	1	0.091067	1	0.89665	1	0.64478	1	0.414	1	0.76743	1	0.54225	1	0.82602	1
CCNE2	13 (5%)	251	0.30284	1	0.76966	1	0.11604	1	0.10182	1	0.43579	1	0.72138	1	0.041685	1	0.3812	1
FRG2B	17 (6%)	247	0.77075	1	0.50814	1	0.92929	1	0.79992	1	0.37235	1	0.73591	1	0.15429	1	0.2066	1
SPAG16	17 (6%)	247	0.22209	1	0.73221	1	0.61851	1	0.37893	1	0.14876	1	0.14713	1	0.19985	1	0.44885	1
USP29	40 (15%)	224	0.85823	1	1	1	0.75777	1	0.6196	1	0.7011	1	0.77768	1	0.31858	1	0.21683	1
GH2	10 (4%)	254	0.17628	1	0.55639	1	0.58854	1	0.58536	1	0.066376	1	0.42507	1	0.60685	1	0.51265	1
ST18	47 (18%)	217	0.30021	1	0.62013	1	0.36891	1	0.19171	1	0.54961	1	0.15916	1	0.87748	1	0.40778	1
CCDC102B	22 (8%)	242	0.91378	1	0.88464	1	0.32381	1	0.30283	1	0.6708	1	0.91871	1	1	1	0.49644	1
B2M	6 (2%)	258	0.94606	1	1	1	0.76622	1	0.86985	1	0.49509	1	0.22639	1	0.022681	1	0.67729	1
CD2	17 (6%)	247	0.9196	1	0.59622	1	0.41032	1	0.41123	1	0.4162	1	0.90259	1	0.69748	1	0.60717	1
SLC38A4	30 (11%)	234	0.5452	1	0.58417	1	0.69271	1	0.94807	1	0.060157	1	0.55715	1	0.77366	1	1	1
OR8D4	11 (4%)	253	0.11407	1	0.53676	1	0.15924	1	0.21334	1	0.17113	1	0.28261	1	0.85868	1	1	1
MKX	16 (6%)	248	0.31325	1	0.34665	1	0.84075	1	0.84058	1	0.31721	1	0.074133	1	0.21828	1	1	1
SPATA8	11 (4%)	253	0.41603	1	0.46141	1	NA	NA	NA	NA	0.34206	1	0.55633	1	0.30634	1	0.21393	1
GPR137	10 (4%)	254	0.27544	1	0.39159	1	1	1	0.86985	1	0.94389	1	0.71603	1	1	1	0.51265	1
GRXCR2	15 (6%)	249	0.68254	1	0.94439	1	0.09373	1	0.8305	1	0.016148	1	0.30359	1	0.6655	1	0.58609	1
C2ORF40	7 (3%)	257	0.44055	1	0.89587	1	0.28701	1	0.43066	1	0.36228	1	1	1	1	1	0.71174	1
CADM2	23 (9%)	241	0.97034	1	0.073828	1	0.34583	1	0.34787	1	0.79437	1	0.7284	1	0.46882	1	0.0026473	1
OR5J2	16 (6%)	248	0.81612	1	0.76149	1	1	1	0.17569	1	0.1963	1	0.51821	1	0.046261	1	0.30179	1
SIGLEC14	12 (5%)	252	0.11961	1	0.60352	1	1	1	0.44419	1	0.34445	1	0.7038	1	1	1	1	1
CX3CL1	4 (2%)	260	0.51272	1	0.13098	1	NA	NA	NA	NA	1	1	0.37734	1	0.095063	1	0.30106	1
GNAI2	4 (2%)	260	0.33377	1	0.36708	1	0.79236	1	1	1	0.17252	1	0.57201	1	0.17022	1	0.15696	1
OR52J3	17 (6%)	247	0.64177	1	0.28212	1	0.3423	1	0.6095	1	0.83783	1	0.94632	1	0.39299	1	0.80078	1
AREG	6 (2%)	258	1	1	0.5786	1	0.58471	1	0.68437	1	0.66978	1	0.33498	1	0.44084	1	0.20607	1
RUNDC3B	15 (6%)	249	0.49387	1	0.011051	1	0.89719	1	0.90415	1	0.91246	1	1	1	0.52723	1	0.7895	1
