rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BFAR(1), BRAF(147), CAMP(1), CREB3(1), CREB5(11), MAPK1(4), RAF1(8), SNX13(1), SRC(1), TERF2IP(2)	4346750	177	155	48	31	31	4	7	131	4	0	0.00294	1.68e-12	1.03e-09
2	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CCND1(1), CDK4(5), CDKN1A(4), CDKN1B(1), CDKN2A(34), CFL1(1), E2F1(7), E2F2(4), MDM2(4), NXT1(2), PRB1(34), TP53(43)	3283462	140	88	108	17	69	4	8	17	42	0	1.38e-10	2.16e-05	0.00664
3	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(18), CCND1(1), CCNE1(4), CCNE2(14), CDK4(5), CDKN1B(1), CDKN2A(34), E2F1(7), E2F2(4), E2F4(1), PRB1(34)	3498413	123	84	95	18	71	0	6	20	26	0	1.52e-07	0.0292	1.000
4	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(10)	279111	10	10	10	2	7	1	1	1	0	0	0.124	0.160	1.000
5	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(12), CDKN2A(34), E2F1(7), MDM2(4), MYC(5), PIK3CA(9), PIK3R1(7), POLR1A(11), POLR1B(9), POLR1C(1), RAC1(17), RB1(8), TBX2(6), TP53(43), TWIST1(1)	7859836	174	108	137	25	87	9	9	18	48	3	7.16e-11	0.434	1.000
6	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(4)	200024	4	4	4	1	4	0	0	0	0	0	0.482	0.533	1.000
7	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(4), FOSB(6), GRIA2(38), JUND(1), PPP1R1B(2)	1422676	51	43	48	16	33	3	2	6	7	0	0.0378	0.767	1.000
8	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(1), MYC(5), SP1(5), SP3(1), TP53(43), WT1(6)	2756180	61	49	52	11	27	3	7	6	18	0	0.00231	0.848	1.000
9	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2), LIPT1(3)	601922	5	4	5	0	0	2	1	1	1	0	0.208	0.901	1.000
10	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(6), GOT2(7), TAT(17)	1024012	30	20	29	8	23	2	2	1	2	0	0.0153	0.933	1.000
11	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(6), DCN(17), FMOD(5), KERA(15), LUM(12)	1368273	55	41	51	18	44	4	3	1	3	0	0.00241	0.936	1.000
12	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(5)	644527	5	5	3	1	4	0	0	1	0	0	0.270	0.963	1.000
13	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(5), CHRNA1(5), SNAP25(6), STX1A(3)	1271830	19	16	16	4	13	1	0	1	4	0	0.0157	0.978	1.000
14	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(4), IL8(1), SLPI(7)	668513	12	12	12	5	6	1	0	4	1	0	0.490	0.991	1.000
15	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(5), ALDOA(2), ALDOB(13), ALDOC(3)	1534583	23	18	19	5	18	2	0	1	2	0	0.0101	0.993	1.000
16	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(5), CD3E(2), CD3G(1)	437385	8	6	8	5	7	0	0	0	1	0	0.701	0.996	1.000
17	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(2), DNAJC3(2), EIF2S1(1), MAP3K14(4), NFKB1(7), NFKBIA(2), RELA(5), TP53(43)	3761973	66	56	57	14	30	6	5	8	17	0	0.00496	0.998	1.000
18	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(6), ATM(13), BAX(3), BCL2(2), CCND1(1), CCNE1(4), CDK4(5), CDKN1A(4), E2F1(7), MDM2(4), PCNA(2), RB1(8), TIMP3(5), TP53(43)	6997545	107	78	96	21	41	8	9	19	28	2	0.000488	0.999	1.000
19	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(2), BCKDK(2), CBS(7), CTH(1), MUT(7)	1975908	19	19	18	6	12	2	1	3	1	0	0.225	1.000	1.000
20	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(3), IDI1(1), SQLE(5)	1234896	9	9	9	3	5	1	1	2	0	0	0.383	1.000	1.000
21	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(2), CASP3(2), CASP8(9), CFL1(1), CFLAR(4), PDE6D(2)	1519563	20	18	19	8	9	1	2	6	2	0	0.553	1.000	1.000
22	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(2), NFYB(3), NFYC(2), RB1(8), SP1(5), SP3(1)	2592449	21	18	21	6	3	2	3	6	5	2	0.355	1.000	1.000
23	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(5), ALDH1A2(12), BCMO1(17), RDH5(2)	1518207	36	32	33	13	25	2	1	4	4	0	0.0549	1.000	1.000
24	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(14), GAD1(15), HDC(22), PNMT(4), TH(9), TPH1(9)	2315032	73	54	69	27	59	3	2	4	5	0	0.00223	1.000	1.000
25	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(2), TGDS(1), UGDH(1), UXS1(4)	1501633	9	9	9	9	4	0	1	0	4	0	0.972	1.000	1.000
26	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(5), ACTR2(3), ACTR3(2), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(3), RAC1(17), WASF1(5), WASL(5)	3158609	47	41	38	10	33	3	1	6	4	0	0.0103	1.000	1.000
27	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(4), ACADM(6), ACADS(4), ECHS1(2), HADHA(8)	2133142	24	22	24	7	14	2	1	7	0	0	0.244	1.000	1.000
28	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(5), BRAF(147), CREB3(1), CREB5(11), DUSP4(3), DUSP6(1), DUSP9(3), EEF2K(7), EIF4E(1), GRB2(2), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK3(1), MKNK1(5), MKNK2(2), MOS(5), NFKB1(7), RAP1A(2), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), SHC1(3), SOS1(9), SOS2(13), TRAF3(5)	11402151	273	181	134	67	99	12	12	141	9	0	0.000887	1.000	1.000
29	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(5), IFNG(2), IL12A(3), IL12B(4), IL18(2), IL2(4)	1145362	20	10	19	8	14	2	0	2	2	0	0.248	1.000	1.000
30	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCR3(11), CSF2(2), HLA-DRA(11), HLA-DRB1(4), IL3(3), IL5(4)	1176397	36	28	35	16	29	2	0	3	2	0	0.0444	1.000	1.000
31	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(18), CCND1(1), CCND2(5), CCND3(2), CCNE1(4), CCNH(2), CDC25A(8), CDK4(5), CDK6(3), CDKN1A(4), CDKN1B(1), CDKN2A(34), CDKN2C(1), E2F1(7), RB1(8), RBL1(11), TFDP1(3)	6272750	117	82	97	26	58	3	7	17	30	2	4.41e-05	1.000	1.000
32	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(4), CDC34(4), CUL1(7), E2F1(7), FBXW7(12), RB1(8), TFDP1(3)	3163515	45	37	44	12	21	3	5	6	8	2	0.0433	1.000	1.000
33	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	CAMP(1), DAG1(6), GNAQ(5), ITPKA(1), ITPKB(6)	2330897	19	19	19	7	12	1	1	2	3	0	0.189	1.000	1.000
34	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(4), MMP14(2), MMP2(7), MMP9(8), RECK(13), TIMP1(1), TIMP2(1), TIMP3(5), TIMP4(6)	2886289	47	39	45	15	27	3	3	10	4	0	0.0561	1.000	1.000
35	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(4), MTMR2(3), MTMR6(2), NFS1(3), TPK1(9)	2486053	22	20	21	7	15	1	2	1	2	1	0.287	1.000	1.000
36	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(5), AASDHPPT(3), AASS(4), KARS(6)	1809763	18	18	18	5	15	0	1	2	0	0	0.229	1.000	1.000
37	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), ECHS1(2), EHHADH(7), GCDH(5), HADHA(8), SDHB(1), SDS(2)	3034624	26	22	25	8	18	3	0	4	1	0	0.105	1.000	1.000
38	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(3), HLCS(7)	1203195	10	10	10	9	7	0	1	1	1	0	0.874	1.000	1.000
39	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(8), SEC61A2(8), SRP19(6), SRP54(3), SRP68(7), SRP72(1), SRP9(1), SRPR(2)	2974087	36	30	31	10	15	0	3	11	7	0	0.292	1.000	1.000
40	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1), HMGCL(4), OXCT1(5)	1309193	10	10	10	5	7	1	0	1	1	0	0.648	1.000	1.000
41	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(11), LPL(3), NR3C1(7), PPARG(11), RETN(3), RXRA(4), TNF(1)	2264302	40	32	38	14	27	2	0	6	5	0	0.0643	1.000	1.000
42	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(18), CCNE1(4), CDC34(4), CUL1(7), E2F1(7), RB1(8), SKP2(2), TFDP1(3)	3306222	53	43	52	15	32	3	4	7	5	2	0.0197	1.000	1.000
43	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(2), GLS2(3), GLUD1(2), GLUD2(4)	1765042	11	9	11	7	3	3	1	1	3	0	0.801	1.000	1.000
44	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(8), CDC25B(6), CDKN1A(4), CHEK1(2), NEK1(9), WEE1(3)	2693558	32	26	32	8	15	6	1	5	5	0	0.157	1.000	1.000
45	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(5), B3GNT1(2), FUT1(3), FUT2(3), FUT9(25), ST8SIA1(1)	2324565	39	36	38	17	30	3	2	4	0	0	0.0955	1.000	1.000
46	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(11), IARS(8), LARS(10), LARS2(5), PDHA1(3), PDHA2(19), PDHB(1)	3913217	57	42	52	13	39	6	1	6	5	0	0.0103	1.000	1.000
47	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(4), DPM2(1), EGR1(4), HRAS(4), KLK2(2), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK3(1), NGFR(8), RAF1(8)	3145509	53	47	44	23	30	4	2	10	7	0	0.130	1.000	1.000
48	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(5), RAB11A(1), RAB1A(1), RAB27A(3), RAB3A(2), RAB5A(1)	1638960	13	11	13	7	10	1	1	1	0	0	0.557	1.000	1.000
49	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), ECHS1(2), HADHA(8), HADHB(4), HSD17B10(2), HSD17B4(6), MECR(6), PPT1(4), PPT2(8)	3297276	42	40	40	14	18	4	4	13	3	0	0.226	1.000	1.000
50	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH6(11), ADH7(13), ADHFE1(6)	2192567	116	77	95	36	91	8	5	9	3	0	0.00130	1.000	1.000
51	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(4), PLCD1(4), PRKCA(11), TGM2(9)	1930848	28	21	27	11	22	2	0	0	4	0	0.0320	1.000	1.000
52	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(5), PSMA2(1), PSMA4(2), PSMA5(4), PSMA6(4), PSMB1(1), PSMB10(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMB8(5)	3426027	29	23	29	9	15	2	2	6	4	0	0.274	1.000	1.000
53	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(16), NR0B2(6), NR1H3(3), NR1H4(15), RXRA(4)	2111130	44	32	44	16	29	7	3	2	3	0	0.0226	1.000	1.000
54	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(3), GGPS1(1), IDI1(1), IDI2(1), SQLE(5)	1651426	11	11	11	5	7	1	1	2	0	0	0.505	1.000	1.000
55	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(12), GOT1(6), GOT2(7), TAT(17), TYR(8)	1827319	50	32	49	22	38	4	3	1	4	0	0.142	1.000	1.000
56	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(5), AASDH(5), AASDHPPT(3), AASS(4), KARS(6)	2683306	23	21	23	7	19	0	1	2	1	0	0.255	1.000	1.000
57	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(4), CDKN1B(1), CUL1(7), E2F1(7), NEDD8(1), RB1(8), SKP2(2), TFDP1(3), UBE2M(1)	3337034	34	33	34	12	15	3	4	4	6	2	0.170	1.000	1.000
58	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(3), AKT2(8), AKT3(4), CDKN1A(4), ELK1(2), GRB2(2), HRAS(4), MAP2K1(13), MAP2K2(4), NGFR(8), NTRK1(19), PIK3CA(9), PIK3CD(7), SHC1(3), SOS1(9)	6185015	99	71	89	29	50	15	3	20	11	0	0.00802	1.000	1.000
59	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(6), BAX(3), BCL10(3), BCL2(2), BCL2L11(5), CASP8AP2(9), CASP9(3), CES1(16)	4188707	47	34	46	13	29	6	2	3	7	0	0.0659	1.000	1.000
60	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(3), ECHS1(2), EHHADH(7), HADHA(8), SDS(2)	1880816	22	20	20	10	14	2	0	5	1	0	0.361	1.000	1.000
61	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(3), ACP2(2), ACP5(3), ACPP(8), ACPT(1), ENPP1(13), ENPP3(15), FLAD1(9), TYR(8)	3750593	62	46	60	19	37	7	3	6	9	0	0.0397	1.000	1.000
62	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(10), CTH(1), GOT1(6), GOT2(7), LDHA(6), LDHB(2), LDHC(5), MPST(2)	2668695	39	30	36	15	29	1	5	2	2	0	0.134	1.000	1.000
63	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(2), NDUFA4(1), NDUFB2(4), NDUFB5(3), NDUFB6(2), NDUFS2(2), NDUFV1(2)	2718775	16	16	16	6	10	0	2	3	1	0	0.489	1.000	1.000
64	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(1), CSF1(11), IL6(2), LDLR(16), LPL(3)	2081416	33	23	33	15	24	3	2	3	1	0	0.207	1.000	1.000
65	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), CYCS(1), GPD2(2), SDHA(3), SDHB(1), SDHC(3), SDHD(1), UQCRC1(3)	2585249	15	15	15	7	11	0	1	1	2	0	0.509	1.000	1.000
66	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(3), ACTR3(2), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(3), PAK1(4), PDGFRA(32), PIK3CA(9), PIK3R1(7), RAC1(17), WASL(5)	5219468	89	65	79	27	56	5	4	12	11	1	0.0419	1.000	1.000
67	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(10), CS(2), MDH1(1), ME1(20), PC(13), PDHA1(3), SLC25A11(2)	3617435	51	37	50	21	29	6	2	10	4	0	0.0971	1.000	1.000
68	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(3), PAPSS2(5), SULT1A2(4), SULT1E1(16), SULT2A1(8), SUOX(5)	2370299	41	25	39	14	32	2	0	2	5	0	0.0821	1.000	1.000
69	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(12), CDO1(6), CSAD(4), GAD1(15), GAD2(10), GGT1(7)	2197674	54	42	53	26	37	4	4	7	2	0	0.229	1.000	1.000
70	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(4), ENO2(4), ENO3(4), FARS2(5), GOT1(6), GOT2(7), PAH(9), TAT(17), YARS(1)	3243541	57	42	54	25	43	5	2	4	3	0	0.0560	1.000	1.000
71	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(3), APEX1(1), CREBBP(23), DFFA(2), DFFB(3), GZMA(11), GZMB(3), HMGB2(1), PRF1(13), SET(3)	4115308	63	44	61	20	37	4	5	11	6	0	0.0670	1.000	1.000
72	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(3), ACP2(2), ACP5(3), ACP6(11), ACPP(8), ACPT(1), ENPP1(13), ENPP3(15), FLAD1(9), LHPP(1), MTMR1(4), MTMR2(3), MTMR6(2), TYR(8)	5819641	83	56	80	23	49	8	7	8	11	0	0.00941	1.000	1.000
73	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(4), IFNG(2), IFNGR1(4), IFNGR2(4), IKBKB(4), JAK2(9), LIN7A(13), NFKB1(7), NFKBIA(2), RB1(8), RELA(5), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TP53(43), USH1C(18), WT1(6)	7009380	136	85	122	37	64	7	8	19	36	2	0.00167	1.000	1.000
74	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(5), ACO2(5), FH(3), IDH1(15), IDH2(2), MDH1(1), MDH2(4), SDHB(1)	3484907	36	29	23	15	26	1	2	4	3	0	0.186	1.000	1.000
75	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(3), ACVR1C(9), AKT1(3), AKT2(8), AKT3(4), ARRB1(3), ARRB2(6), ATF2(5), ATF4(7), BDNF(5), BRAF(147), CACNA1A(36), CACNA1B(28), CACNA1C(46), CACNA1D(34), CACNA1E(101), CACNA1F(21), CACNA1G(30), CACNA1H(26), CACNA1I(34), CACNA1S(48), CACNA2D1(14), CACNA2D2(15), CACNA2D3(49), CACNA2D4(19), CACNB1(4), CACNB2(13), CACNB3(2), CACNB4(11), CACNG1(3), CACNG2(9), CACNG3(20), CACNG4(3), CACNG5(12), CACNG6(6), CACNG7(6), CACNG8(1), CASP3(2), CD14(5), CDC25B(6), CDC42(3), CHP(3), CHUK(2), CRK(3), CRKL(2), DAXX(10), DDIT3(2), DUSP10(6), DUSP14(2), DUSP16(5), DUSP2(1), DUSP3(2), DUSP4(3), DUSP5(2), DUSP6(1), DUSP7(2), DUSP8(4), DUSP9(3), ECSIT(4), EGF(19), EGFR(23), ELK1(2), ELK4(7), FAS(5), FASLG(14), FGF1(1), FGF10(2), FGF11(2), FGF12(12), FGF13(8), FGF14(5), FGF16(8), FGF17(2), FGF18(2), FGF19(3), FGF2(2), FGF21(4), FGF23(8), FGF3(5), FGF4(2), FGF5(5), FGF6(6), FGF7(7), FGF8(1), FGF9(4), FGFR1(11), FGFR2(32), FGFR3(10), FGFR4(10), FLNA(15), FLNB(43), FLNC(60), FOS(2), GADD45B(2), GADD45G(1), GNA12(3), GRB2(2), HRAS(4), IKBKB(4), IL1A(4), IL1B(7), IL1R1(12), IL1R2(9), JUN(1), JUND(1), KRAS(4), MAP2K1(13), MAP2K2(4), MAP2K3(9), MAP2K4(4), MAP2K5(3), MAP2K6(3), MAP2K7(4), MAP3K1(3), MAP3K10(8), MAP3K12(4), MAP3K13(10), MAP3K14(4), MAP3K2(6), MAP3K3(6), MAP3K4(16), MAP3K5(18), MAP3K6(6), MAP3K7(1), MAP4K1(9), MAP4K2(6), MAP4K3(8), MAP4K4(8), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(2), MAPK13(5), MAPK14(5), MAPK3(1), MAPK7(4), MAPK8(2), MAPK8IP1(5), MAPK8IP2(9), MAPK8IP3(9), MAPK9(7), MAPKAPK2(5), MAPKAPK3(4), MAPKAPK5(1), MAPT(12), MEF2C(3), MKNK1(5), MKNK2(2), MOS(5), MRAS(2), MYC(5), NF1(47), NFATC2(9), NFATC4(13), NFKB1(7), NFKB2(5), NLK(6), NR4A1(4), NRAS(73), NTF3(6), NTRK1(19), NTRK2(9), PAK1(4), PAK2(8), PDGFA(1), PDGFB(4), PDGFRA(32), PDGFRB(18), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(7), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), PPM1A(3), PPM1B(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(8), PPP5C(2), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(11), PRKCG(14), PRKX(4), PTPN5(12), PTPN7(3), PTPRR(26), RAC1(17), RAC2(1), RAF1(8), RAP1A(2), RAP1B(1), RAPGEF2(10), RASA1(4), RASA2(15), RASGRF1(23), RASGRF2(20), RASGRP1(9), RASGRP2(7), RASGRP3(15), RASGRP4(11), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), RPS6KA4(4), RPS6KA5(4), RPS6KA6(16), RRAS(1), SOS1(9), SOS2(13), SRF(2), STK4(3), STMN1(3), TAOK1(12), TAOK2(25), TAOK3(4), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(7), TNF(1), TNFRSF1A(3), TP53(43), TRAF2(3), TRAF6(5), ZAK(7)	109301390	2299	253	1994	1189	1380	193	108	396	217	5	0.0117	1.000	1.000
76	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ACTN1(5), ACTN2(24), ACTN3(7), ACTN4(5), APC(22), APC2(9), ARAF(5), ARHGEF1(1), ARHGEF12(12), ARHGEF4(6), ARHGEF6(10), ARHGEF7(4), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), ARPC5(1), BAIAP2(7), BCAR1(5), BDKRB1(5), BDKRB2(10), BRAF(147), CD14(5), CDC42(3), CFL1(1), CHRM1(5), CHRM2(19), CHRM3(22), CHRM4(6), CHRM5(4), CRK(3), CRKL(2), CSK(1), CYFIP1(7), CYFIP2(24), DIAPH1(6), DIAPH2(7), DIAPH3(12), DOCK1(15), EGF(19), EGFR(23), EZR(1), F2(9), F2R(7), FGD1(4), FGD3(8), FGF1(1), FGF10(2), FGF11(2), FGF12(12), FGF13(8), FGF14(5), FGF16(8), FGF17(2), FGF18(2), FGF19(3), FGF2(2), FGF21(4), FGF23(8), FGF3(5), FGF4(2), FGF5(5), FGF6(6), FGF7(7), FGF8(1), FGF9(4), FGFR1(11), FGFR2(32), FGFR3(10), FGFR4(10), FN1(25), GIT1(4), GNA12(3), GNA13(1), GRLF1(12), GSN(6), HRAS(4), IQGAP1(10), IQGAP2(24), IQGAP3(11), ITGA1(18), ITGA10(10), ITGA11(17), ITGA2(14), ITGA2B(11), ITGA3(7), ITGA4(38), ITGA5(25), ITGA6(8), ITGA7(25), ITGA8(36), ITGA9(14), ITGAD(26), ITGAE(19), ITGAL(24), ITGAM(21), ITGAV(9), ITGAX(20), ITGB1(4), ITGB2(14), ITGB3(12), ITGB4(22), ITGB5(7), ITGB6(12), ITGB7(6), ITGB8(17), KRAS(4), LIMK1(4), LIMK2(9), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK3(1), MOS(5), MRAS(2), MSN(1), MYH10(13), MYH14(17), MYH9(12), MYL2(5), MYL5(1), MYL7(2), MYL9(2), MYLK(41), MYLK2(13), MYLPF(2), NCKAP1(7), NCKAP1L(33), NRAS(73), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PAK7(48), PDGFA(1), PDGFB(4), PDGFRA(32), PDGFRB(18), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PIP4K2A(5), PIP4K2B(3), PIP4K2C(3), PIP5K1A(6), PIP5K1B(20), PIP5K1C(8), PPP1CA(2), PPP1CB(5), PPP1CC(2), PPP1R12A(5), PPP1R12B(8), PTK2(8), PXN(3), RAC1(17), RAC2(1), RAF1(8), RDX(1), RHOA(1), ROCK1(5), ROCK2(13), RRAS(1), SCIN(8), SLC9A1(4), SOS1(9), SOS2(13), SSH1(14), SSH2(8), SSH3(3), TIAM1(27), TIAM2(29), TMSL3(2), VAV1(16), VAV2(4), VAV3(10), VCL(7), WAS(7), WASF1(5), WASF2(5), WASL(5)	106408273	1991	250	1713	912	1204	115	97	403	168	4	7.33e-06	1.000	1.000
77	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(7), ACTG1(5), ACTN1(5), ACTN2(24), ACTN3(7), ACTN4(5), AKT1(3), AKT2(8), AKT3(4), ARHGAP5(12), BCAR1(5), BCL2(2), BIRC2(5), BIRC3(8), BRAF(147), CAPN2(6), CAV1(2), CCND1(1), CCND2(5), CCND3(2), CDC42(3), CHAD(4), COL11A1(65), COL11A2(40), COL1A1(44), COL1A2(42), COL2A1(30), COL3A1(72), COL4A1(62), COL4A2(33), COL4A4(97), COL4A6(35), COL5A1(65), COL5A2(45), COL5A3(71), COL6A1(9), COL6A2(21), COL6A3(60), COL6A6(59), COMP(7), CRK(3), CRKL(2), CTNNB1(13), DIAPH1(6), DOCK1(15), EGF(19), EGFR(23), ELK1(2), ERBB2(7), FARP2(6), FIGF(4), FLNA(15), FLNB(43), FLNC(60), FLT1(33), FN1(25), FYN(7), GRB2(2), GRLF1(12), GSK3B(2), HGF(24), HRAS(4), IBSP(8), IGF1(11), IGF1R(11), ITGA1(18), ITGA10(10), ITGA11(17), ITGA2(14), ITGA2B(11), ITGA3(7), ITGA4(38), ITGA5(25), ITGA6(8), ITGA7(25), ITGA8(36), ITGA9(14), ITGAV(9), ITGB1(4), ITGB3(12), ITGB4(22), ITGB5(7), ITGB6(12), ITGB7(6), ITGB8(17), JUN(1), KDR(45), LAMA1(42), LAMA2(59), LAMA3(62), LAMA4(11), LAMA5(29), LAMB1(10), LAMB2(11), LAMB3(27), LAMB4(40), LAMC1(10), LAMC2(21), LAMC3(7), MAP2K1(13), MAPK1(4), MAPK10(9), MAPK3(1), MAPK8(2), MAPK9(7), MET(23), MYL2(5), MYL5(1), MYL7(2), MYL9(2), MYLK(41), MYLK2(13), MYLPF(2), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PAK7(48), PARVA(2), PARVB(3), PARVG(4), PDGFA(1), PDGFB(4), PDGFC(18), PDGFD(7), PDGFRA(32), PDGFRB(18), PDPK1(4), PGF(1), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PIP5K1C(8), PPP1CA(2), PPP1CB(5), PPP1CC(2), PPP1R12A(5), PRKCA(11), PRKCG(14), PTEN(23), PTK2(8), PXN(3), RAC1(17), RAC2(1), RAF1(8), RAP1A(2), RAP1B(1), RAPGEF1(10), RELN(76), RHOA(1), ROCK1(5), ROCK2(13), SHC1(3), SHC2(7), SHC3(12), SHC4(2), SOS1(9), SOS2(13), SPP1(7), SRC(1), THBS1(30), THBS2(10), THBS3(11), THBS4(11), TLN1(14), TLN2(25), TNC(32), TNN(46), TNR(76), TNXB(143), VASP(3), VAV1(16), VAV2(4), VAV3(10), VCL(7), VEGFA(7), VEGFB(1), VEGFC(19), VTN(7), VWF(51), ZYX(7)	143618917	3363	246	3078	1375	2322	218	104	442	274	3	6.62e-12	1.000	1.000
78	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(5), BRAF(147), C7orf16(1), CACNA1A(36), CRH(3), CRHR1(7), GNA11(7), GNA12(3), GNA13(1), GNAI1(1), GNAI2(5), GNAI3(3), GNAO1(2), GNAQ(5), GNAS(22), GNAZ(6), GRIA1(45), GRIA2(38), GRIA3(23), GRID2(52), GRM1(17), GRM5(15), GUCY1A2(21), GUCY1A3(34), GUCY1B3(7), GUCY2C(32), GUCY2D(10), GUCY2F(16), HRAS(4), IGF1(11), IGF1R(11), ITPR1(36), ITPR2(18), ITPR3(9), KRAS(4), LYN(7), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK3(1), NOS1(65), NOS3(17), NPR1(18), NPR2(14), NRAS(73), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(7), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(4), PPP2R2A(2), PPP2R2B(6), PPP2R2C(6), PRKCA(11), PRKCG(14), PRKG1(13), PRKG2(16), RAF1(8), RYR1(93)	42302442	1256	245	976	595	763	70	66	270	86	1	7.34e-05	1.000	1.000
79	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(5), BRAF(147), CASP3(2), CD244(9), CD247(3), CD48(5), CHP(3), CSF2(2), FAS(5), FASLG(14), FCER1G(1), FCGR3A(9), FCGR3B(3), FYN(7), GRB2(2), GZMB(3), HLA-A(3), HLA-B(5), HLA-C(1), HLA-E(1), HLA-G(4), HRAS(4), ICAM1(3), ICAM2(4), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(10), IFNA17(2), IFNA2(1), IFNA21(9), IFNA4(1), IFNA5(3), IFNA6(3), IFNA7(5), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IFNG(2), IFNGR1(4), IFNGR2(4), ITGAL(24), ITGB2(14), KIR2DL1(21), KIR2DL3(6), KIR2DL4(4), KIR3DL1(18), KIR3DL2(2), KLRC1(5), KLRC2(1), KLRC3(11), KLRD1(5), KLRK1(5), KRAS(4), LAT(1), LCK(14), LCP2(10), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK3(1), MICA(4), MICB(4), NCR1(13), NCR2(11), NCR3(3), NFAT5(8), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NRAS(73), PAK1(4), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PLCG1(9), PLCG2(25), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(8), PRF1(13), PRKCA(11), PRKCG(14), PTK2B(11), PTPN11(10), PTPN6(3), RAC1(17), RAC2(1), RAF1(8), SH2D1A(2), SH2D1B(3), SH3BP2(2), SHC1(3), SHC2(7), SHC3(12), SHC4(2), SOS1(9), SOS2(13), SYK(16), TNF(1), TNFRSF10A(5), TNFRSF10B(3), TNFRSF10C(4), TNFRSF10D(8), TNFSF10(8), TYROBP(5), ULBP1(2), ULBP3(5), VAV1(16), VAV2(4), VAV3(10), ZAP70(7)	43669952	1033	243	791	386	561	58	64	276	73	1	1.76e-06	1.000	1.000
80	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(21), ADORA1(6), ADORA2A(2), ADORA2B(3), ADORA3(12), ADRA1A(10), ADRA1B(4), ADRA2A(3), ADRA2B(9), ADRA2C(2), ADRB1(5), ADRB2(2), AGTR1(11), AGTR2(12), AVPR1A(4), AVPR1B(9), AVPR2(1), BDKRB1(5), BDKRB2(10), BRS3(5), C3AR1(5), C5AR1(9), CALCR(17), CALCRL(15), CCKAR(10), CCKBR(12), CGA(1), CHRM1(5), CHRM2(19), CHRM3(22), CHRM4(6), CHRM5(4), CNR1(9), CNR2(4), CRHR1(7), CRHR2(4), CTSG(4), CYSLTR1(5), CYSLTR2(4), DRD1(11), DRD2(17), DRD3(6), DRD4(1), DRD5(23), EDNRA(9), EDNRB(5), F2(9), F2R(7), F2RL1(16), F2RL2(6), F2RL3(3), FPR1(20), FSHB(4), FSHR(19), GABBR1(8), GABBR2(10), GABRA1(16), GABRA2(16), GABRA3(19), GABRA4(13), GABRA5(3), GABRA6(24), GABRB1(16), GABRB2(20), GABRB3(19), GABRD(5), GABRE(20), GABRG1(29), GABRG2(15), GABRG3(7), GABRP(14), GABRQ(11), GABRR1(8), GABRR2(1), GALR1(5), GALR2(1), GALR3(2), GH1(3), GH2(10), GHR(30), GHRHR(4), GHSR(11), GIPR(2), GLP1R(11), GLP2R(14), GLRA1(12), GLRA2(6), GLRA3(14), GLRB(29), GNRHR(2), GPR156(10), GPR35(3), GPR50(20), GPR63(6), GPR83(14), GRIA1(45), GRIA2(38), GRIA3(23), GRIA4(24), GRID1(24), GRID2(52), GRIK1(23), GRIK2(21), GRIK3(30), GRIK4(13), GRIK5(12), GRIN1(7), GRIN2A(91), GRIN2B(56), GRIN2C(8), GRIN2D(6), GRIN3A(42), GRIN3B(5), GRM1(17), GRM2(9), GRM3(54), GRM4(20), GRM5(15), GRM6(27), GRM7(39), GRM8(50), GRPR(5), GZMA(11), HCRTR1(3), HCRTR2(29), HRH1(18), HRH2(4), HRH3(4), HRH4(5), HTR1A(8), HTR1B(1), HTR1D(3), HTR1E(6), HTR1F(8), HTR2A(9), HTR2B(2), HTR2C(12), HTR4(10), HTR5A(17), HTR6(1), HTR7(8), LEP(2), LEPR(25), LHCGR(27), LTB4R(1), LTB4R2(1), MAS1(4), MC2R(5), MC3R(7), MC4R(1), MC5R(7), MCHR1(4), MCHR2(17), MLNR(1), MTNR1A(8), MTNR1B(7), NMBR(8), NMUR1(6), NMUR2(15), NPBWR1(2), NPBWR2(12), NPFFR1(1), NPFFR2(12), NPY1R(25), NPY2R(14), NPY5R(24), NR3C1(7), NTSR1(6), NTSR2(3), OPRD1(2), OPRK1(23), OPRL1(5), OPRM1(5), OXTR(5), P2RX1(4), P2RX2(3), P2RX3(10), P2RX4(2), P2RX5(8), P2RX7(5), P2RY1(4), P2RY10(7), P2RY13(4), P2RY14(9), P2RY2(8), P2RY6(1), P2RY8(8), PARD3(17), PPYR1(12), PRL(1), PRLHR(2), PRLR(30), PRSS1(27), PRSS3(4), PTAFR(2), PTGDR(9), PTGER2(6), PTGER3(3), PTGER4(1), PTGFR(22), PTGIR(6), PTH2R(16), RXFP1(19), RXFP2(24), SCTR(10), SSTR1(11), SSTR2(6), SSTR3(12), SSTR4(4), SSTR5(3), TAAR1(2), TAAR2(9), TAAR5(4), TAAR6(11), TAAR8(7), TAAR9(3), TACR1(8), TACR2(8), TACR3(28), TBXA2R(4), THRA(4), THRB(17), TRHR(21), TRPV1(2), TSHB(7), TSHR(11), UTS2R(1), VIPR1(4), VIPR2(5)	85072129	2620	240	2418	1602	1835	227	92	241	223	2	5.40e-10	1.000	1.000
81	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(29), ADCY8(51), ARAF(5), ATF4(7), BRAF(147), CACNA1C(46), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CAMK4(12), CHP(3), CREBBP(23), EP300(14), GNAQ(5), GRIA1(45), GRIA2(38), GRIN1(7), GRIN2A(91), GRIN2B(56), GRIN2C(8), GRIN2D(6), GRM1(17), GRM5(15), HRAS(4), ITPR1(36), ITPR2(18), ITPR3(9), KRAS(4), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK3(1), NRAS(73), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), PPP1CA(2), PPP1CB(5), PPP1CC(2), PPP1R12A(5), PPP1R1A(4), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(8), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(11), PRKCG(14), PRKX(4), RAF1(8), RAP1A(2), RAP1B(1), RAPGEF3(13), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), RPS6KA6(16)	38098065	1104	240	844	512	631	70	67	268	67	1	0.000840	1.000	1.000
82	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(21), ACACB(21), AKT1(3), AKT2(8), AKT3(4), ARAF(5), BRAF(147), CALM1(1), CALM2(1), CALML3(6), CBL(11), CBLB(19), CBLC(15), CRK(3), CRKL(2), EIF4EBP1(1), ELK1(2), EXOC7(8), FASN(17), FBP1(2), FBP2(2), FLOT1(2), FOXO1(6), G6PC(7), G6PC2(7), GCK(20), GRB2(2), GSK3B(2), GYS1(3), GYS2(22), HRAS(4), IKBKB(4), INPP5D(37), INSR(22), IRS1(6), IRS2(2), IRS4(12), KRAS(4), LIPE(9), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK10(9), MAPK3(1), MAPK8(2), MAPK9(7), MKNK1(5), MKNK2(2), NRAS(73), PCK1(23), PCK2(4), PDE3A(27), PDE3B(6), PDPK1(4), PFKL(4), PFKM(2), PHKA1(23), PHKA2(7), PHKB(7), PHKG1(1), PHKG2(2), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PKLR(11), PKM2(5), PPARGC1A(22), PPP1CA(2), PPP1CB(5), PPP1CC(2), PPP1R3A(62), PPP1R3B(6), PPP1R3C(3), PPP1R3D(3), PRKAA1(1), PRKAA2(26), PRKAB1(2), PRKAB2(2), PRKACA(4), PRKACB(4), PRKACG(8), PRKAG1(2), PRKAG2(9), PRKAG3(10), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCI(8), PRKCZ(6), PRKX(4), PTPN1(4), PTPRF(28), PYGB(2), PYGL(9), PYGM(10), RAF1(8), RAPGEF1(10), RHEB(2), RHOQ(1), RPS6(1), RPS6KB1(2), RPS6KB2(3), SH2B2(5), SHC1(3), SHC2(7), SHC3(12), SHC4(2), SLC2A4(8), SOCS2(2), SOCS3(2), SOCS4(3), SORBS1(13), SOS1(9), SOS2(13), SREBF1(5), TRIP10(4), TSC1(5), TSC2(12)	61839857	1198	240	955	436	665	70	74	293	93	3	2.35e-09	1.000	1.000
83	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(12), ABL2(12), AKT1(3), AKT2(8), AKT3(4), ARAF(5), AREG(7), BRAF(147), BTC(4), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CBL(11), CBLB(19), CBLC(15), CDKN1A(4), CDKN1B(1), CRK(3), CRKL(2), EGF(19), EGFR(23), EIF4EBP1(1), ELK1(2), ERBB2(7), ERBB3(6), ERBB4(50), EREG(6), GAB1(4), GRB2(2), GSK3B(2), HBEGF(1), HRAS(4), JUN(1), KRAS(4), MAP2K1(13), MAP2K2(4), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(9), MAPK3(1), MAPK8(2), MAPK9(7), MYC(5), NCK1(1), NCK2(6), NRAS(73), NRG1(17), NRG2(7), NRG3(21), NRG4(1), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PAK7(48), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PLCG1(9), PLCG2(25), PRKCA(11), PRKCG(14), PTK2(8), RAF1(8), RPS6KB1(2), RPS6KB2(3), SHC1(3), SHC2(7), SHC3(12), SHC4(2), SOS1(9), SOS2(13), SRC(1), STAT5A(3), STAT5B(4), TGFA(3)	39707254	901	238	664	295	453	49	67	271	60	1	2.16e-07	1.000	1.000
84	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(7), ACTG1(5), CHAD(4), COL11A1(65), COL11A2(40), COL17A1(29), COL1A1(44), COL1A2(42), COL2A1(30), COL3A1(72), COL4A1(62), COL4A2(33), COL4A4(97), COL4A6(35), COL5A1(65), COL5A2(45), COL5A3(71), COL6A1(9), COL6A2(21), COL6A3(60), COL6A6(59), COMP(7), DES(8), DSC1(47), DSC2(36), DSC3(40), DSG1(61), DSG2(21), DSG3(65), DSG4(62), FN1(25), GJA1(8), GJA10(14), GJA3(1), GJA4(4), GJA5(7), GJA8(18), GJA9(3), GJB1(1), GJB2(3), GJB3(3), GJB4(7), GJB5(6), GJB6(6), GJB7(2), GJC1(7), GJC2(1), GJC3(2), GJD2(7), IBSP(8), INA(6), ITGA6(8), ITGB4(22), KRT1(19), KRT10(15), KRT12(12), KRT13(11), KRT14(2), KRT15(12), KRT16(12), KRT17(9), KRT18(4), KRT2(18), KRT20(7), KRT23(8), KRT24(8), KRT25(10), KRT27(5), KRT28(11), KRT3(16), KRT31(11), KRT32(11), KRT33A(5), KRT33B(3), KRT34(10), KRT35(9), KRT36(16), KRT37(11), KRT38(9), KRT39(13), KRT4(18), KRT40(6), KRT5(18), KRT6A(17), KRT6B(10), KRT6C(13), KRT7(6), KRT71(17), KRT72(12), KRT73(16), KRT74(14), KRT75(16), KRT76(12), KRT77(13), KRT78(20), KRT79(8), KRT8(7), KRT81(3), KRT82(9), KRT83(15), KRT84(10), KRT85(7), KRT86(7), KRT9(19), LAMA1(42), LAMA2(59), LAMA3(62), LAMA4(11), LAMA5(29), LAMB1(10), LAMB2(11), LAMB3(27), LAMB4(40), LAMC1(10), LAMC2(21), LAMC3(7), LMNA(9), LMNB1(2), LMNB2(4), NES(21), PRPH(1), RELN(76), SPP1(7), THBS1(30), THBS2(10), THBS3(11), THBS4(11), TNC(32), TNN(46), TNR(76), TNXB(143), VIM(5), VTN(7), VWF(51)	96655005	2852	231	2704	1218	2148	210	67	220	206	1	7.06e-11	1.000	1.000
85	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(29), ADCY2(8), ADCY3(4), ADCY4(6), ADCY7(10), ADCY8(51), ADCY9(9), ADORA2A(2), ADORA2B(3), ADRA1A(10), ADRA1B(4), ADRA1D(4), ADRB1(5), ADRB2(2), AGTR1(11), ATP2A1(9), ATP2A2(14), ATP2A3(16), ATP2B1(8), ATP2B2(30), ATP2B3(9), ATP2B4(16), AVPR1A(4), AVPR1B(9), BDKRB1(5), BDKRB2(10), BST1(1), CACNA1A(36), CACNA1B(28), CACNA1C(46), CACNA1D(34), CACNA1E(101), CACNA1F(21), CACNA1G(30), CACNA1H(26), CACNA1I(34), CACNA1S(48), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CAMK4(12), CCKAR(10), CCKBR(12), CD38(4), CHP(3), CHRM1(5), CHRM2(19), CHRM3(22), CHRM5(4), CHRNA7(3), CYSLTR1(5), CYSLTR2(4), DRD1(11), EDNRA(9), EDNRB(5), EGFR(23), ERBB2(7), ERBB3(6), ERBB4(50), F2R(7), GNA11(7), GNA14(5), GNA15(5), GNAL(2), GNAQ(5), GNAS(22), GRIN1(7), GRIN2A(91), GRIN2C(8), GRIN2D(6), GRM1(17), GRM5(15), GRPR(5), HRH1(18), HRH2(4), HTR2A(9), HTR2B(2), HTR2C(12), HTR4(10), HTR5A(17), HTR6(1), HTR7(8), ITPKA(1), ITPKB(6), ITPR1(36), ITPR2(18), ITPR3(9), LHCGR(27), LTB4R2(1), MYLK(41), MYLK2(13), NOS1(65), NOS3(17), NTSR1(6), OXTR(5), P2RX1(4), P2RX2(3), P2RX3(10), P2RX4(2), P2RX5(8), P2RX7(5), PDE1A(37), PDE1B(13), PDE1C(44), PDGFRA(32), PDGFRB(18), PHKA1(23), PHKA2(7), PHKB(7), PHKG1(1), PHKG2(2), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), PLCD1(4), PLCD3(3), PLCD4(4), PLCE1(53), PLCG1(9), PLCG2(25), PLCZ1(26), PPID(1), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(8), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(11), PRKCG(14), PRKX(4), PTAFR(2), PTGER3(3), PTGFR(22), PTK2B(11), RYR1(93), RYR2(90), RYR3(81), SLC25A6(2), SLC8A1(32), SLC8A2(11), SLC8A3(39), SPHK1(1), SPHK2(7), TACR1(8), TACR2(8), TACR3(28), TBXA2R(4), TNNC1(2), TNNC2(3), TRHR(21), TRPC1(6), VDAC1(1), VDAC2(1), VDAC3(1)	103030060	2489	231	2340	1601	1778	183	86	221	216	5	0.00629	1.000	1.000
86	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1(4), ACVR1B(3), ACVR2A(3), ACVR2B(3), AMHR2(16), BMP2(6), BMP7(2), BMPR1A(2), BMPR1B(4), BMPR2(6), CCL1(1), CCL11(1), CCL13(1), CCL14(2), CCL15(3), CCL16(1), CCL18(1), CCL2(1), CCL20(2), CCL21(2), CCL22(1), CCL23(1), CCL24(3), CCL25(1), CCL26(1), CCL27(2), CCL28(1), CCL7(4), CCL8(3), CCR1(10), CCR2(17), CCR3(11), CCR4(8), CCR5(7), CCR6(3), CCR7(3), CCR8(6), CCR9(5), CD27(3), CD40(4), CD40LG(2), CLCF1(1), CNTF(1), CNTFR(3), CSF1(11), CSF1R(13), CSF2(2), CSF2RA(20), CSF2RB(18), CSF3(5), CSF3R(8), CX3CL1(4), CX3CR1(13), CXCL10(3), CXCL11(1), CXCL12(2), CXCL13(1), CXCL14(1), CXCL3(1), CXCL5(2), CXCL6(1), CXCL9(3), CXCR3(5), CXCR4(4), CXCR6(4), EDA(2), EDA2R(4), EDAR(5), EGF(19), EGFR(23), EPO(6), EPOR(1), FAS(5), FASLG(14), FLT1(33), FLT3(31), FLT3LG(2), FLT4(27), GDF5(14), GH1(3), GH2(10), GHR(30), HGF(24), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(10), IFNA17(2), IFNA2(1), IFNA21(9), IFNA4(1), IFNA5(3), IFNA6(3), IFNA7(5), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IFNG(2), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(4), IL10(3), IL10RA(8), IL10RB(5), IL11(2), IL11RA(3), IL12A(3), IL12B(4), IL12RB1(17), IL12RB2(3), IL13(2), IL13RA1(3), IL15(3), IL15RA(7), IL17A(10), IL17B(3), IL17RA(6), IL17RB(2), IL18(2), IL18R1(17), IL18RAP(19), IL19(3), IL1A(4), IL1B(7), IL1R1(12), IL1R2(9), IL1RAP(4), IL2(4), IL20(4), IL20RA(10), IL21(6), IL21R(18), IL22(2), IL22RA1(12), IL22RA2(1), IL23A(2), IL23R(7), IL25(2), IL26(3), IL28A(2), IL28B(4), IL28RA(4), IL29(2), IL2RA(4), IL2RB(7), IL2RG(3), IL3(3), IL3RA(8), IL4(1), IL4R(14), IL5(4), IL5RA(14), IL6(2), IL6R(4), IL6ST(10), IL7(5), IL7R(33), IL8(1), IL9(1), IL9R(6), INHBA(19), INHBB(8), INHBC(11), INHBE(3), KDR(45), KIT(10), KITLG(9), LEP(2), LEPR(25), LIF(2), LIFR(33), LTA(2), LTB(2), MET(23), MPL(8), NGFR(8), OSM(8), OSMR(40), PDGFB(4), PDGFC(18), PDGFRA(32), PDGFRB(18), PLEKHO2(5), PPBP(5), PRL(1), PRLR(30), RELT(2), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(7), TNF(1), TNFRSF10A(5), TNFRSF10B(3), TNFRSF10C(4), TNFRSF10D(8), TNFRSF11A(5), TNFRSF11B(10), TNFRSF12A(1), TNFRSF13B(8), TNFRSF14(2), TNFRSF17(6), TNFRSF18(4), TNFRSF19(2), TNFRSF1A(3), TNFRSF1B(3), TNFRSF21(10), TNFRSF25(5), TNFRSF4(4), TNFRSF6B(2), TNFRSF8(20), TNFRSF9(4), TNFSF10(8), TNFSF11(4), TNFSF12(1), TNFSF13B(1), TNFSF14(11), TNFSF15(7), TNFSF18(7), TNFSF4(3), TNFSF8(4), TNFSF9(1), TPO(45), TSLP(1), VEGFA(7), VEGFB(1), VEGFC(19), XCL1(1), XCL2(2), XCR1(4)	68381179	1603	229	1536	869	1144	111	45	143	160	0	0.0164	1.000	1.000
87	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(12), ACTN1(5), ACTR2(3), ACTR3(2), AKT1(3), AKT2(8), AKT3(4), ANGPTL2(3), ARHGEF6(10), ARHGEF7(4), BCAR1(5), BRAF(147), CAV1(2), CDC42(3), CDKN2A(34), CRK(3), CSE1L(5), DOCK1(15), EPHB2(31), FYN(7), GRB2(2), GRB7(6), GRLF1(12), ITGA1(18), ITGA10(10), ITGA11(17), ITGA2(14), ITGA3(7), ITGA4(38), ITGA5(25), ITGA6(8), ITGA7(25), ITGA8(36), ITGA9(14), ITGB3BP(2), MAP2K4(4), MAP2K7(4), MAP3K11(6), MAPK1(4), MAPK10(9), MAPK8(2), MAPK8IP1(5), MAPK8IP2(9), MAPK8IP3(9), MAPK9(7), MRAS(2), MYLK(41), MYLK2(13), P4HB(3), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PAK7(48), PIK3CA(9), PIK3CB(26), PKLR(11), PLCG1(9), PLCG2(25), PTEN(23), PTK2(8), RAF1(8), RALA(1), RHO(2), ROCK1(5), ROCK2(13), SHC1(3), SOS1(9), SOS2(13), SRC(1), TERF2IP(2), TLN1(14), TLN2(25), VASP(3), WAS(7), ZYX(7)	47101145	961	229	774	354	517	53	40	245	106	0	1.28e-06	1.000	1.000
88	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(13), CD36(4), CD44(6), CD47(1), CHAD(4), COL11A1(65), COL11A2(40), COL1A1(44), COL1A2(42), COL2A1(30), COL3A1(72), COL4A1(62), COL4A2(33), COL4A4(97), COL4A6(35), COL5A1(65), COL5A2(45), COL5A3(71), COL6A1(9), COL6A2(21), COL6A3(60), COL6A6(59), DAG1(6), FN1(25), FNDC1(40), FNDC3A(11), FNDC4(5), FNDC5(3), GP5(4), GP6(5), GP9(6), HMMR(4), HSPG2(26), IBSP(8), ITGA1(18), ITGA10(10), ITGA11(17), ITGA2(14), ITGA2B(11), ITGA3(7), ITGA4(38), ITGA5(25), ITGA6(8), ITGA7(25), ITGA8(36), ITGA9(14), ITGAV(9), ITGB1(4), ITGB3(12), ITGB4(22), ITGB5(7), ITGB6(12), ITGB7(6), ITGB8(17), LAMA1(42), LAMA2(59), LAMA3(62), LAMA4(11), LAMA5(29), LAMB1(10), LAMB2(11), LAMB3(27), LAMB4(40), LAMC1(10), LAMC2(21), LAMC3(7), RELN(76), SDC1(4), SDC2(2), SDC3(6), SDC4(3), SPP1(7), SV2A(16), SV2B(30), SV2C(14), THBS1(30), THBS2(10), THBS3(11), THBS4(11), TNC(32), TNN(46), TNR(76), TNXB(143), VTN(7), VWF(51)	86770935	2237	226	2143	939	1676	132	65	188	175	1	8.19e-05	1.000	1.000
89	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(12), ABLIM1(13), ABLIM2(6), ABLIM3(9), ARHGEF12(12), CDC42(3), CDK5(4), CFL1(1), CHP(3), CXCL12(2), CXCR4(4), DCC(81), DPYSL2(4), DPYSL5(13), EFNA2(1), EFNA4(2), EFNA5(3), EFNB1(1), EFNB3(5), EPHA1(17), EPHA2(14), EPHA3(26), EPHA4(19), EPHA5(7), EPHA6(69), EPHA7(44), EPHA8(16), EPHB1(27), EPHB2(31), EPHB3(15), EPHB4(11), EPHB6(27), FES(7), FYN(7), GNAI1(1), GNAI2(5), GNAI3(3), GSK3B(2), HRAS(4), ITGB1(4), KRAS(4), L1CAM(9), LIMK1(4), LIMK2(9), LRRC4C(39), MAPK1(4), MAPK3(1), MET(23), NCK1(1), NCK2(6), NFAT5(8), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NGEF(14), NRAS(73), NRP1(23), NTN4(17), NTNG1(15), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PAK7(48), PLXNA1(14), PLXNA2(13), PLXNA3(10), PLXNB1(22), PLXNB2(16), PLXNB3(7), PLXNC1(18), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(8), PTK2(8), RAC1(17), RAC2(1), RASA1(4), RGS3(13), RHOA(1), RHOD(2), RND1(5), ROBO1(23), ROBO2(38), ROBO3(14), ROCK1(5), ROCK2(13), SEMA3A(13), SEMA3B(2), SEMA3C(3), SEMA3D(13), SEMA3E(25), SEMA3F(10), SEMA3G(14), SEMA4A(10), SEMA4B(4), SEMA4C(7), SEMA4D(10), SEMA4F(6), SEMA4G(9), SEMA5A(19), SEMA5B(17), SEMA6A(8), SEMA6B(7), SEMA6C(9), SEMA6D(5), SEMA7A(3), SLIT1(18), SLIT2(61), SLIT3(53), SRGAP1(6), SRGAP2(7), SRGAP3(34), UNC5A(9), UNC5B(12), UNC5C(19), UNC5D(27)	75447909	1614	224	1460	800	1077	121	74	210	130	2	0.000793	1.000	1.000
90	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTB(7), ACTG1(5), ACTN1(5), ACTN2(24), ACTN3(7), ACTN4(5), AKT1(3), AKT2(8), AKT3(4), AMOTL1(2), ASH1L(28), CASK(5), CDC42(3), CDK4(5), CGN(9), CLDN1(5), CLDN10(5), CLDN11(5), CLDN14(5), CLDN16(7), CLDN17(6), CLDN18(7), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(1), CLDN4(10), CLDN6(9), CLDN7(1), CLDN8(3), CLDN9(1), CRB3(1), CSDA(3), CSNK2A1(1), CSNK2A2(1), CSNK2B(2), CTNNA1(2), CTNNA2(27), CTNNA3(30), CTNNB1(13), CTTN(3), EPB41(8), EPB41L1(11), EPB41L2(20), EPB41L3(6), EXOC3(3), EXOC4(9), F11R(5), GNAI1(1), GNAI2(5), GNAI3(3), HCLS1(14), HRAS(4), IGSF5(11), INADL(42), JAM2(10), JAM3(2), KRAS(4), LLGL1(4), LLGL2(14), MAGI1(28), MAGI2(29), MAGI3(12), MLLT4(13), MPDZ(13), MPP5(1), MRAS(2), MYH1(96), MYH10(13), MYH11(28), MYH13(39), MYH14(17), MYH15(56), MYH2(86), MYH3(21), MYH4(86), MYH6(32), MYH7(47), MYH7B(25), MYH8(58), MYH9(12), MYL2(5), MYL5(1), MYL7(2), MYL9(2), MYLPF(2), NRAS(73), OCLN(4), PARD3(17), PARD6A(2), PARD6B(2), PARD6G(3), PPM1J(1), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(4), PPP2R2A(2), PPP2R2B(6), PPP2R2C(6), PPP2R3A(7), PPP2R3B(4), PPP2R4(2), PRKCA(11), PRKCD(4), PRKCE(6), PRKCG(14), PRKCH(11), PRKCI(8), PRKCQ(18), PRKCZ(6), PTEN(23), RAB3B(1), RHOA(1), RRAS(1), SPTAN1(8), SRC(1), SYMPK(6), TJAP1(3), TJP1(11), TJP2(9), TJP3(21), VAPA(1), YES1(5), ZAK(7)	74802542	1495	224	1354	890	975	132	75	184	126	3	0.337	1.000	1.000
91	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(147), CPEB1(8), EGFR(23), ERBB2(7), ERBB4(50), ETS1(5), ETS2(9), ETV6(13), ETV7(3), FMN2(74), GRB2(2), KRAS(4), MAP2K1(13), MAPK1(4), MAPK3(1), NOTCH1(5), NOTCH2(41), NOTCH3(23), NOTCH4(57), PIWIL1(21), PIWIL2(13), PIWIL3(13), PIWIL4(6), RAF1(8), SOS1(9), SOS2(13), SPIRE1(2), SPIRE2(6)	20321583	580	221	426	181	305	25	20	196	34	0	0.000121	1.000	1.000
92	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(5), ACTA2(4), ACTN2(24), ACTN3(7), ACTN4(5), DES(8), DMD(34), FAM48A(1), MYBPC1(20), MYBPC2(19), MYBPC3(18), MYH3(21), MYH6(32), MYH7(47), MYH8(58), MYL1(12), MYL2(5), MYL3(2), MYL4(5), MYL9(2), MYOM1(24), NEB(119), TCAP(1), TNNC2(3), TNNI1(2), TNNI2(3), TNNI3(2), TNNT1(3), TNNT2(4), TNNT3(3), TPM1(3), TPM2(3), TPM3(2), TPM4(2), TTN(1177), VIM(5)	51509623	1685	221	1558	718	1253	115	56	157	93	11	7.31e-08	1.000	1.000
93	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(29), ADCY2(8), ADCY3(4), ADCY4(6), ADCY5(17), ADCY6(7), ADCY7(10), ADCY8(51), ADCY9(9), ADRA1A(10), ADRA1B(4), ADRA1D(4), ADRB1(5), ADRB2(2), ANXA6(6), ARRB1(3), ARRB2(6), ATP1A4(12), ATP1B1(1), ATP1B2(2), ATP1B3(1), ATP2A2(14), ATP2A3(16), ATP2B1(8), ATP2B2(30), ATP2B3(9), CACNA1A(36), CACNA1B(28), CACNA1C(46), CACNA1D(34), CACNA1E(101), CACNA1S(48), CACNB1(4), CACNB3(2), CALM1(1), CALM2(1), CALR(1), CAMK1(5), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CAMK4(12), CASQ1(9), CASQ2(5), CHRM1(5), CHRM2(19), CHRM3(22), CHRM4(6), CHRM5(4), GJA1(8), GJA4(4), GJA5(7), GJB1(1), GJB2(3), GJB3(3), GJB4(7), GJB5(6), GJB6(6), GNA11(7), GNAI2(5), GNAI3(3), GNAO1(2), GNAQ(5), GNAZ(6), GNB3(7), GNB4(3), GNB5(3), GNG2(3), GNG4(2), GNG7(2), GRK4(8), GRK5(4), GRK6(3), ITPR1(36), ITPR2(18), ITPR3(9), KCNB1(37), KCNJ3(22), KCNJ5(15), MIB1(6), NME7(4), PKIA(4), PKIB(1), PKIG(1), PLCB3(6), PRKACA(4), PRKACB(4), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(11), PRKCD(4), PRKCE(6), PRKCG(14), PRKCH(11), PRKCQ(18), PRKCZ(6), PRKD1(3), RGS1(3), RGS11(2), RGS14(3), RGS16(2), RGS18(10), RGS20(2), RGS3(13), RGS4(3), RGS5(2), RGS6(16), RGS7(40), RGS9(11), RYR1(93), RYR2(90), RYR3(81), SFN(1), SLC8A1(32), SLC8A3(39), USP5(4), YWHAB(1), YWHAQ(3)	71995250	1495	220	1407	1039	1037	140	60	131	124	3	0.656	1.000	1.000
94	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(29), ADCY2(8), ADCY3(4), ADCY4(6), ADCY5(17), ADCY6(7), ADCY7(10), ADCY8(51), ADCY9(9), ADRB1(5), CSNK1D(1), DRD1(11), DRD2(17), EGF(19), EGFR(23), GJA1(8), GJD2(7), GNA11(7), GNAI1(1), GNAI2(5), GNAI3(3), GNAQ(5), GNAS(22), GRB2(2), GRM1(17), GRM5(15), GUCY1A2(21), GUCY1A3(34), GUCY1B3(7), GUCY2C(32), GUCY2D(10), GUCY2F(16), HRAS(4), HTR2A(9), HTR2B(2), HTR2C(12), ITPR1(36), ITPR2(18), ITPR3(9), KRAS(4), MAP2K1(13), MAP2K2(4), MAP2K5(3), MAP3K2(6), MAPK1(4), MAPK3(1), MAPK7(4), NPR1(18), NPR2(14), NRAS(73), PDGFA(1), PDGFB(4), PDGFC(18), PDGFD(7), PDGFRA(32), PDGFRB(18), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(11), PRKCG(14), PRKG1(13), PRKG2(16), PRKX(4), RAF1(8), SOS1(9), SOS2(13), SRC(1), TJP1(11), TUBA1A(2), TUBA1B(4), TUBA1C(2), TUBA3C(22), TUBA3D(12), TUBA3E(4), TUBA4A(6), TUBA8(3), TUBAL3(13), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(5), TUBB4(4), TUBB4Q(10), TUBB6(10), TUBB8(15)	50875953	1119	216	985	572	722	86	75	154	81	1	0.000350	1.000	1.000
95	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(5), BRAF(147), CHUK(2), DAXX(10), ELK1(2), FOS(2), GRB2(2), HRAS(4), IKBKB(4), JUN(1), MAP2K1(13), MAP2K2(4), MAP2K3(9), MAP2K4(4), MAP2K5(3), MAP2K6(3), MAP2K7(4), MAP3K1(3), MAP3K10(8), MAP3K11(6), MAP3K12(4), MAP3K13(10), MAP3K14(4), MAP3K2(6), MAP3K3(6), MAP3K4(16), MAP3K5(18), MAP3K6(6), MAP3K7(1), MAP3K9(24), MAP4K1(9), MAP4K2(6), MAP4K3(8), MAP4K4(8), MAP4K5(3), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(2), MAPK13(5), MAPK14(5), MAPK3(1), MAPK4(18), MAPK6(6), MAPK7(4), MAPK8(2), MAPK9(7), MAPKAPK2(5), MAPKAPK3(4), MAPKAPK5(1), MEF2A(5), MEF2B(3), MEF2C(3), MEF2D(5), MKNK1(5), MKNK2(2), MYC(5), NFKB1(7), NFKBIA(2), PAK1(4), PAK2(8), RAC1(17), RAF1(8), RELA(5), RIPK1(1), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), RPS6KA4(4), RPS6KA5(4), RPS6KB1(2), RPS6KB2(3), SHC1(3), SP1(5), STAT1(4), TGFB1(1), TGFB2(1), TGFB3(3), TRAF2(3)	36577293	571	215	418	203	275	46	25	187	38	0	0.00258	1.000	1.000
96	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(5), ACTA2(4), ADCY1(29), ADCY2(8), ADCY3(4), ADCY4(6), ADCY5(17), ADCY6(7), ADCY7(10), ADCY8(51), ADCY9(9), ARRB1(3), ARRB2(6), ATF1(5), ATF2(5), ATF4(7), ATF5(7), ATP2A2(14), ATP2A3(16), CACNB3(2), CALCA(2), CALM1(1), CALM2(1), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CNN1(6), CNN2(2), CORIN(31), CREB3(1), CRH(3), CRHR1(7), DGKZ(8), ETS2(9), FOS(2), GABPA(1), GABPB2(9), GBA2(2), GJA1(8), GNAQ(5), GNB3(7), GNB4(3), GNB5(3), GNG2(3), GNG4(2), GNG7(2), GRK4(8), GRK5(4), GRK6(3), GSTO1(2), GUCA2A(1), GUCA2B(1), GUCY1A3(34), IGFBP1(3), IGFBP2(2), IGFBP3(2), IGFBP6(2), IL1B(7), IL6(2), ITPR1(36), ITPR2(18), ITPR3(9), JUN(1), MIB1(6), MYL2(5), MYL4(5), MYLK2(13), NFKB1(7), NOS1(65), NOS3(17), OXTR(5), PDE4B(7), PDE4D(8), PKIA(4), PKIB(1), PKIG(1), PLCB3(6), PLCD1(4), PLCG1(9), PLCG2(25), PRKACA(4), PRKACB(4), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(11), PRKCD(4), PRKCE(6), PRKCH(11), PRKCQ(18), PRKCZ(6), PRKD1(3), RAMP1(1), RAMP2(1), RAMP3(2), RGS1(3), RGS11(2), RGS14(3), RGS16(2), RGS18(10), RGS20(2), RGS3(13), RGS4(3), RGS5(2), RGS6(16), RGS7(40), RGS9(11), RLN1(3), RYR1(93), RYR2(90), RYR3(81), SFN(1), SLC8A1(32), SP1(5), TNXB(143), USP5(4), YWHAB(1), YWHAQ(3)	67241494	1323	215	1250	774	936	113	48	124	99	3	0.0212	1.000	1.000
97	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(3), AKT2(8), AKT3(4), CBL(11), CBLB(19), CBLC(15), CCND1(1), CCND2(5), CCND3(2), CISH(3), CLCF1(1), CNTF(1), CNTFR(3), CREBBP(23), CSF2(2), CSF2RA(20), CSF2RB(18), CSF3(5), CSF3R(8), EP300(14), EPO(6), EPOR(1), GH1(3), GH2(10), GHR(30), GRB2(2), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(10), IFNA17(2), IFNA2(1), IFNA21(9), IFNA4(1), IFNA5(3), IFNA6(3), IFNA7(5), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IFNG(2), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(4), IL10(3), IL10RA(8), IL10RB(5), IL11(2), IL11RA(3), IL12A(3), IL12B(4), IL12RB1(17), IL12RB2(3), IL13(2), IL13RA1(3), IL13RA2(3), IL15(3), IL15RA(7), IL19(3), IL2(4), IL20(4), IL20RA(10), IL21(6), IL21R(18), IL22(2), IL22RA1(12), IL22RA2(1), IL23A(2), IL23R(7), IL26(3), IL28A(2), IL28B(4), IL28RA(4), IL29(2), IL2RA(4), IL2RB(7), IL2RG(3), IL3(3), IL3RA(8), IL4(1), IL4R(14), IL5(4), IL5RA(14), IL6(2), IL6R(4), IL6ST(10), IL7(5), IL7R(33), IL9(1), IL9R(6), IRF9(2), JAK1(6), JAK2(9), JAK3(7), LEP(2), LEPR(25), LIF(2), LIFR(33), MPL(8), MYC(5), OSM(8), OSMR(40), PIAS1(5), PIAS2(6), PIAS3(5), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PIM1(2), PRL(1), PRLR(30), PTPN11(10), PTPN6(3), SOCS2(2), SOCS3(2), SOCS4(3), SOCS5(5), SOCS7(4), SOS1(9), SOS2(13), SPRED1(5), SPRED2(2), SPRY1(7), SPRY2(4), SPRY3(12), SPRY4(2), STAM(4), STAM2(1), STAT1(4), STAT2(8), STAT3(11), STAT4(22), STAT5A(3), STAT5B(4), STAT6(8), TPO(45), TSLP(1), TYK2(8)	56307861	1057	214	1013	486	695	80	38	134	109	1	0.00774	1.000	1.000
98	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(3), AKT2(8), AKT3(4), BRAF(147), DAG1(6), DRD2(17), EGFR(23), EPHB2(31), GRB2(2), ITPKA(1), ITPKB(6), ITPR1(36), ITPR2(18), ITPR3(9), KCNJ3(22), KCNJ5(15), KCNJ9(4), MAPK1(4), PI3(6), PIK3CB(26), PITX2(4), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), RAF1(8), RGS20(2), SHC1(3), SOS1(9), SOS2(13), SRC(1), STAT3(11), TERF2IP(2)	22648202	582	212	420	219	290	37	33	185	36	1	0.000201	1.000	1.000
99	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(22), APC2(9), AXIN1(11), AXIN2(4), BTRC(5), CACYBP(2), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CCND1(1), CCND2(5), CCND3(2), CER1(13), CHD8(23), CHP(3), CREBBP(23), CSNK1A1(3), CSNK1A1L(6), CSNK1E(4), CSNK2A1(1), CSNK2A2(1), CSNK2B(2), CTBP2(1), CTNNB1(13), CTNNBIP1(1), CUL1(7), CXXC4(1), DAAM1(5), DAAM2(6), DKK1(2), DKK2(17), DKK4(3), DVL2(3), DVL3(7), EP300(14), FBXW11(5), FZD1(4), FZD10(2), FZD2(5), FZD4(2), FZD5(2), FZD6(2), FZD7(4), FZD8(6), FZD9(1), GSK3B(2), JUN(1), LEF1(3), LRP5(19), LRP6(26), MAP3K7(1), MAPK10(9), MAPK8(2), MAPK9(7), MMP7(6), MYC(5), NFAT5(8), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NKD1(8), NKD2(6), NLK(6), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), PORCN(5), PPARD(3), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(4), PPP2R2A(2), PPP2R2B(6), PPP2R2C(6), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(8), PRICKLE1(10), PRICKLE2(6), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(11), PRKCG(14), PRKX(4), PSEN1(1), RAC1(17), RAC2(1), RHOA(1), ROCK1(5), ROCK2(13), RUVBL1(1), SENP2(12), SFRP1(2), SFRP2(10), SFRP4(6), SMAD2(3), SMAD3(2), SMAD4(2), SOX17(6), TBL1X(5), TBL1XR1(1), TBL1Y(7), TCF7(2), TCF7L1(3), TCF7L2(7), TP53(43), VANGL1(2), VANGL2(9), WIF1(8), WNT1(2), WNT10A(7), WNT10B(5), WNT11(4), WNT16(1), WNT2(7), WNT2B(5), WNT3(6), WNT3A(6), WNT4(2), WNT5A(5), WNT5B(5), WNT6(2), WNT7A(14), WNT7B(6), WNT8A(7), WNT8B(7), WNT9A(3), WNT9B(3)	62137458	949	211	899	445	592	75	46	134	101	1	0.0188	1.000	1.000
100	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(6), ADORA2A(2), ADORA2B(3), ADORA3(12), ADRA1A(10), ADRA1B(4), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(2), AGTR1(11), AGTR2(12), AVPR1A(4), AVPR1B(9), AVPR2(1), BDKRB1(5), BDKRB2(10), BRS3(5), C3AR1(5), CCBP2(8), CCKAR(10), CCKBR(12), CCR1(10), CCR10(2), CCR2(17), CCR3(11), CCR4(8), CCR5(7), CCR6(3), CCR7(3), CCR8(6), CCR9(5), CCRL1(1), CCRL2(5), CHML(4), CHRM1(5), CHRM2(19), CHRM3(22), CHRM4(6), CHRM5(4), CMKLR1(13), CNR1(9), CNR2(4), CX3CR1(13), CXCR3(5), CXCR4(4), DRD1(11), DRD2(17), DRD3(6), DRD4(1), DRD5(23), EDNRA(9), EDNRB(5), F2R(7), F2RL1(16), F2RL2(6), F2RL3(3), FPR1(20), FSHR(19), GALR1(5), GALR2(1), GALR3(2), GALT(2), GHSR(11), GNB2L1(3), GPR17(1), GPR173(1), GPR174(12), GPR27(2), GPR3(2), GPR35(3), GPR37(9), GPR37L1(6), GPR4(4), GPR50(20), GPR6(6), GPR63(6), GPR77(5), GPR83(14), GPR85(5), GPR87(5), GRPR(5), HCRTR1(3), HCRTR2(29), HRH1(18), HRH2(4), HRH3(4), HTR1A(8), HTR1B(1), HTR1D(3), HTR1E(6), HTR1F(8), HTR2A(9), HTR2B(2), HTR2C(12), HTR4(10), HTR5A(17), HTR6(1), HTR7(8), LHCGR(27), LTB4R(1), MAS1(4), MC3R(7), MC4R(1), MC5R(7), MLNR(1), MTNR1A(8), MTNR1B(7), NMBR(8), NMUR1(6), NMUR2(15), NPY1R(25), NPY2R(14), NPY5R(24), NTSR1(6), NTSR2(3), OPN1SW(2), OPN3(3), OPRD1(2), OPRK1(23), OPRL1(5), OPRM1(5), OR10A5(7), OR11A1(7), OR12D3(5), OR1C1(11), OR1F1(7), OR1Q1(8), OR2H1(7), OR5V1(10), OR7A5(3), OR7C1(2), OR8B8(10), OXTR(5), P2RY1(4), P2RY10(7), P2RY12(3), P2RY13(4), P2RY14(9), P2RY2(8), P2RY6(1), PPYR1(12), PTAFR(2), PTGDR(9), PTGER2(6), PTGER4(1), PTGFR(22), PTGIR(6), RGR(6), RHO(2), RRH(1), SSTR1(11), SSTR2(6), SSTR3(12), SSTR4(4), SUCNR1(10), TBXA2R(4), TRHR(21)	46836893	1204	208	1133	909	810	129	39	137	89	0	0.00393	1.000	1.000
101	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(25), BDKRB1(5), BDKRB2(10), C1QA(5), C1QB(5), C1QC(8), C1R(14), C1S(20), C2(16), C3(49), C3AR1(5), C4BPA(18), C4BPB(6), C5(16), C5AR1(9), C6(66), C7(52), C8A(40), C8B(48), C8G(1), C9(22), CD55(4), CD59(1), CFB(33), CFH(49), CFI(16), CPB2(1), CR1(54), CR2(33), F10(10), F11(15), F12(1), F13A1(28), F13B(24), F2(9), F2R(7), F3(2), F5(37), F7(9), F8(46), F9(12), FGA(42), FGB(10), FGG(8), KLKB1(25), KNG1(14), MASP1(9), MASP2(9), MBL2(13), PLAT(4), PLAU(3), PLAUR(2), PLG(33), PROC(9), PROS1(13), SERPINA1(7), SERPINA5(11), SERPINC1(8), SERPIND1(4), SERPINE1(5), SERPINF2(8), SERPING1(12), TFPI(10), THBD(3), VWF(51)	34918588	1144	208	1059	474	813	84	44	111	90	2	1.11e-05	1.000	1.000
102	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(6), CADM1(3), CADM3(19), CD2(23), CD22(26), CD226(6), CD274(1), CD276(6), CD28(1), CD34(4), CD4(6), CD40(4), CD40LG(2), CD58(1), CD6(10), CD80(5), CD86(21), CD8A(2), CD8B(8), CD99(2), CDH1(7), CDH15(10), CDH2(13), CDH4(29), CDH5(12), CLDN1(5), CLDN10(5), CLDN11(5), CLDN14(5), CLDN16(7), CLDN17(6), CLDN18(7), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(1), CLDN4(10), CLDN6(9), CLDN7(1), CLDN8(3), CLDN9(1), CNTN1(22), CNTN2(15), CNTNAP1(11), CNTNAP2(81), CTLA4(2), ESAM(3), F11R(5), GLG1(6), HLA-A(3), HLA-B(5), HLA-C(1), HLA-DMA(4), HLA-DMB(7), HLA-DOA(5), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(7), HLA-DQB1(5), HLA-DRA(11), HLA-DRB1(4), HLA-DRB5(1), HLA-E(1), HLA-F(6), HLA-G(4), ICAM1(3), ICAM2(4), ICAM3(2), ICOS(3), ICOSLG(2), ITGA4(38), ITGA6(8), ITGA8(36), ITGA9(14), ITGAL(24), ITGAM(21), ITGAV(9), ITGB1(4), ITGB2(14), ITGB7(6), ITGB8(17), JAM2(10), JAM3(2), L1CAM(9), MADCAM1(1), MAG(12), MPZ(5), MPZL1(1), NCAM1(11), NCAM2(10), NEGR1(6), NEO1(15), NFASC(39), NLGN1(10), NLGN2(6), NLGN3(6), NRCAM(9), NRXN1(47), NRXN2(17), NRXN3(30), OCLN(4), PDCD1(3), PDCD1LG2(3), PTPRC(33), PTPRF(28), PTPRM(8), PVR(3), PVRL1(4), PVRL2(6), PVRL3(5), SDC1(4), SDC2(2), SDC3(6), SDC4(3), SELE(36), SELL(8), SELP(31), SELPLG(8), SIGLEC1(26), SPN(6), VCAM1(18), VCAN(41)	56622608	1260	206	1198	587	883	96	46	135	100	0	6.41e-06	1.000	1.000
103	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(29), ADCY2(8), ADCY3(4), ADCY4(6), ADCY5(17), ADCY6(7), ADCY7(10), ADCY8(51), ADCY9(9), ATF4(7), CACNA1C(46), CACNA1D(34), CACNA1F(21), CACNA1S(48), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CDC42(3), CGA(1), EGFR(23), ELK1(2), FSHB(4), GNA11(7), GNAQ(5), GNAS(22), GNRH2(2), GNRHR(2), GRB2(2), HBEGF(1), HRAS(4), ITPR1(36), ITPR2(18), ITPR3(9), JUN(1), KRAS(4), MAP2K1(13), MAP2K2(4), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(4), MAP3K1(3), MAP3K2(6), MAP3K3(6), MAP3K4(16), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(2), MAPK13(5), MAPK14(5), MAPK3(1), MAPK7(4), MAPK8(2), MAPK9(7), MMP14(2), MMP2(7), NRAS(73), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(7), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), PLD1(12), PLD2(7), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(11), PRKCD(4), PRKX(4), PTK2B(11), RAF1(8), SOS1(9), SOS2(13), SRC(1)	48763050	964	206	844	552	598	80	71	140	74	1	0.171	1.000	1.000
104	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(29), ADCY2(8), ADCY3(4), ADCY4(6), ADCY5(17), ADCY6(7), ADCY7(10), ADCY8(51), ADCY9(9), AKAP1(10), AKAP10(3), AKAP11(17), AKAP12(4), AKAP3(21), AKAP4(16), AKAP6(39), AKAP7(3), AKAP8(6), AKAP9(31), ARHGEF1(1), CALM1(1), CALM2(1), CHMP1B(1), GNA11(7), GNA12(3), GNA13(1), GNA14(5), GNA15(5), GNAI2(5), GNAI3(3), GNAL(2), GNAO1(2), GNAQ(5), GNAZ(6), GNB3(7), GNB5(3), GNG4(2), GNG7(2), GNGT2(4), HRAS(4), ITPR1(36), KCNJ3(22), KRAS(4), NRAS(73), PDE1A(37), PDE1B(13), PDE1C(44), PDE4A(9), PDE4B(7), PDE4C(18), PDE4D(8), PDE7A(2), PDE7B(17), PDE8A(3), PDE8B(21), PLCB3(6), PPP3CA(5), PPP3CC(2), PRKACA(4), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(11), PRKCD(4), PRKCE(6), PRKCG(14), PRKCH(11), PRKCI(8), PRKCQ(18), PRKCZ(6), PRKD1(3), PRKD3(4), RHOA(1), RRAS(1), SLC9A1(4), USP5(4)	45219945	810	205	712	422	510	60	61	126	53	0	0.0802	1.000	1.000
105	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(29), ADCY2(8), ADCY3(4), ADCY4(6), ADCY5(17), ADCY6(7), ADCY7(10), ADCY8(51), ADCY9(9), ASIP(2), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CREB3(1), CREB3L1(6), CREB3L2(7), CREB3L3(10), CREB3L4(5), CREBBP(23), CTNNB1(13), DCT(3), DVL2(3), DVL3(7), EDN1(9), EDNRB(5), EP300(14), FZD1(4), FZD10(2), FZD2(5), FZD4(2), FZD5(2), FZD6(2), FZD7(4), FZD8(6), FZD9(1), GNAI1(1), GNAI2(5), GNAI3(3), GNAO1(2), GNAQ(5), GNAS(22), GSK3B(2), HRAS(4), KIT(10), KITLG(9), KRAS(4), LEF1(3), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK3(1), MITF(4), NRAS(73), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), POMC(3), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(11), PRKCG(14), PRKX(4), RAF1(8), TCF7(2), TCF7L1(3), TCF7L2(7), TYR(8), TYRP1(8), WNT1(2), WNT10A(7), WNT10B(5), WNT11(4), WNT16(1), WNT2(7), WNT2B(5), WNT3(6), WNT3A(6), WNT4(2), WNT5A(5), WNT5B(5), WNT6(2), WNT7A(14), WNT7B(6), WNT8A(7), WNT8B(7), WNT9A(3), WNT9B(3)	41763117	798	205	688	417	481	64	64	122	66	1	0.0294	1.000	1.000
106	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(3), AKT2(8), AKT3(4), BRAF(147), CAB39(1), DDIT4(1), EIF4B(4), EIF4EBP1(1), FIGF(4), HIF1A(5), IGF1(11), MAPK1(4), MAPK3(1), PDPK1(4), PGF(1), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PRKAA1(1), PRKAA2(26), RHEB(2), RICTOR(10), RPS6(1), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), RPS6KA6(16), RPS6KB1(2), RPS6KB2(3), STK11(4), TSC1(5), TSC2(12), ULK1(8), ULK2(7), ULK3(1), VEGFA(7), VEGFB(1), VEGFC(19)	20408770	438	203	288	125	182	20	20	177	37	2	4.37e-05	1.000	1.000
107	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(3), ATF1(5), BRAF(147), CAMP(1), CREB3(1), CREB5(11), CREBBP(23), CRKL(2), DAG1(6), EGR1(4), EGR2(4), EGR3(2), EGR4(5), ELK1(2), FRS2(5), GNAQ(5), JUN(1), MAP1B(21), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(9), MAPK3(1), MAPK8(2), MAPK8IP1(5), MAPK8IP2(9), MAPK8IP3(9), MAPK9(7), NTRK1(19), OPN1LW(5), PIK3C2G(50), PIK3CA(9), PIK3CD(7), PIK3R1(7), PTPN11(10), RPS6KA3(2), SHC1(3), SRC(1), TERF2IP(2), TH(9)	19789879	426	203	286	127	195	21	17	163	29	1	7.80e-05	1.000	1.000
108	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(3), ADCY1(29), ADCY2(8), ADCY3(4), ADCY4(6), ADCY5(17), ADCY6(7), ADCY7(10), ADCY8(51), ADCY9(9), ADK(4), ADSL(7), ADSS(2), ADSSL1(8), AK1(1), AK2(3), AK5(7), AK7(22), ALLC(9), AMPD1(31), AMPD2(5), AMPD3(22), APRT(3), ATIC(5), CANT1(9), DGUOK(4), ENPP1(13), ENPP3(15), ENTPD1(11), ENTPD2(4), ENTPD3(6), ENTPD4(4), ENTPD5(2), ENTPD6(5), ENTPD8(2), FHIT(3), GART(10), GDA(13), GMPR2(2), GMPS(6), GUCY1A2(21), GUCY1A3(34), GUCY1B3(7), GUCY2C(32), GUCY2D(10), GUCY2F(16), GUK1(2), IMPDH1(2), IMPDH2(1), NME6(3), NME7(4), NPR1(18), NPR2(14), NT5C1A(3), NT5C1B(24), NT5C2(3), NT5C3(2), NT5E(4), NT5M(2), NUDT5(2), NUDT9(2), PAICS(1), PAPSS1(3), PAPSS2(5), PDE10A(13), PDE11A(19), PDE1A(37), PDE1C(44), PDE2A(14), PDE3B(6), PDE4A(9), PDE4B(7), PDE4C(18), PDE4D(8), PDE5A(8), PDE6D(2), PDE6G(2), PDE7A(2), PDE7B(17), PDE8A(3), PDE8B(21), PDE9A(10), PFAS(9), PKLR(11), PKM2(5), PNPT1(2), POLA1(2), POLA2(9), POLD1(6), POLD2(2), POLD3(4), POLE(16), POLE2(3), POLR1A(11), POLR1B(9), POLR1C(1), POLR2A(12), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(5), POLR3B(15), POLR3G(1), POLR3GL(1), POLR3H(2), POLR3K(1), PRIM1(3), PRIM2(15), PRPS1(2), PRPS1L1(14), PRPS2(4), PRUNE(2), RRM1(3), RRM2(2), RRM2B(3), XDH(56), ZNRD1(1)	63262995	1090	200	1039	543	756	88	51	106	89	0	0.000953	1.000	1.000
109	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ABL1(12), ANAPC1(17), ANAPC10(1), ANAPC2(5), ANAPC4(4), ANAPC5(7), ANAPC7(6), ATM(13), ATR(25), BUB1(6), BUB1B(9), CCNA1(18), CCNB2(3), CCNB3(29), CCND1(1), CCND2(5), CCND3(2), CCNE1(4), CCNE2(14), CCNH(2), CDC14A(5), CDC14B(1), CDC16(2), CDC20(1), CDC23(3), CDC25A(8), CDC25B(6), CDC25C(5), CDC27(10), CDC6(1), CDC7(3), CDK4(5), CDK6(3), CDKN1A(4), CDKN1B(1), CDKN2A(34), CDKN2C(1), CHEK1(2), CHEK2(2), CREBBP(23), CUL1(7), DBF4(5), E2F1(7), E2F2(4), E2F3(6), EP300(14), ESPL1(14), FZR1(7), GADD45B(2), GADD45G(1), GSK3B(2), HDAC1(1), HDAC2(1), MAD1L1(5), MAD2L1(1), MAD2L2(1), MCM2(11), MCM3(10), MCM4(7), MCM5(4), MCM6(5), MDM2(4), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), PKMYT1(3), PLK1(3), PRKDC(20), PTTG1(1), PTTG2(5), RB1(8), RBL1(11), RBL2(6), SFN(1), SKP2(2), SMAD2(3), SMAD3(2), SMAD4(2), SMC1A(3), SMC1B(21), TFDP1(3), TGFB1(1), TGFB2(1), TGFB3(3), TP53(43), WEE1(3), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3)	52898509	588	200	543	199	307	43	43	106	87	2	3.69e-05	1.000	1.000
110	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(1), CALM2(1), CALML3(6), CDS1(11), CDS2(4), DGKA(4), DGKB(24), DGKD(11), DGKE(7), DGKG(18), DGKH(8), DGKI(26), DGKQ(6), DGKZ(8), IMPA1(2), IMPA2(2), INPP1(2), INPP4A(6), INPP4B(4), INPP5A(4), INPP5B(6), INPP5D(37), INPPL1(15), ITGB1BP3(2), ITPK1(6), ITPKA(1), ITPKB(6), ITPR1(36), ITPR2(18), ITPR3(9), OCRL(5), PI4KA(18), PI4KB(4), PIK3C2A(8), PIK3C2B(14), PIK3C2G(50), PIK3C3(3), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PIP4K2A(5), PIP4K2B(3), PIP4K2C(3), PIP5K1A(6), PIP5K1B(20), PIP5K1C(8), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), PLCD1(4), PLCD3(3), PLCD4(4), PLCE1(53), PLCG1(9), PLCG2(25), PLCZ1(26), PRKCA(11), PRKCG(14), PTEN(23), SYNJ1(23), SYNJ2(16)	47912010	885	198	822	395	590	50	39	114	90	2	4.09e-05	1.000	1.000
111	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(3), AKT2(8), AKT3(4), BCL10(3), CARD11(35), CBL(11), CBLB(19), CBLC(15), CD247(3), CD28(1), CD3D(5), CD3E(2), CD3G(1), CD4(6), CD40LG(2), CD8A(2), CD8B(8), CDC42(3), CDK4(5), CHP(3), CHUK(2), CSF2(2), CTLA4(2), FOS(2), FYN(7), GRAP2(5), GRB2(2), HRAS(4), ICOS(3), IFNG(2), IKBKB(4), IL10(3), IL2(4), IL4(1), IL5(4), ITK(21), JUN(1), KRAS(4), LAT(1), LCK(14), LCP2(10), MALT1(8), MAP3K14(4), NCK1(1), NCK2(6), NFAT5(8), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB1(7), NFKB2(5), NFKBIA(2), NFKBIB(1), NRAS(73), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PAK7(48), PDCD1(3), PDK1(2), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(8), PRKCQ(18), PTPN6(3), PTPRC(33), RASGRP1(9), RHOA(1), SOS1(9), SOS2(13), TEC(10), TNF(1), VAV1(16), VAV2(4), VAV3(10), ZAP70(7)	39258673	740	197	642	304	424	51	58	143	63	1	0.00302	1.000	1.000
112	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(5), ACTN2(24), ACTN3(7), ACTN4(5), ARHGAP5(12), BCAR1(5), CD99(2), CDC42(3), CDH5(12), CLDN1(5), CLDN10(5), CLDN11(5), CLDN14(5), CLDN16(7), CLDN17(6), CLDN18(7), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(1), CLDN4(10), CLDN6(9), CLDN7(1), CLDN8(3), CLDN9(1), CTNNA1(2), CTNNA2(27), CTNNA3(30), CTNNB1(13), CTNND1(9), CXCL12(2), CXCR4(4), CYBA(1), CYBB(7), ESAM(3), EZR(1), F11R(5), GNAI1(1), GNAI2(5), GNAI3(3), GRLF1(12), ICAM1(3), ITGA4(38), ITGAL(24), ITGAM(21), ITGB1(4), ITGB2(14), ITK(21), JAM2(10), JAM3(2), MAPK11(1), MAPK12(2), MAPK13(5), MAPK14(5), MLLT4(13), MMP2(7), MMP9(8), MSN(1), MYL2(5), MYL5(1), MYL7(2), MYL9(2), MYLPF(2), NCF1(1), NCF2(7), NCF4(4), NOX1(11), NOX3(9), OCLN(4), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PLCG1(9), PLCG2(25), PRKCA(11), PRKCG(14), PTK2(8), PTK2B(11), PTPN11(10), PXN(3), RAC1(17), RAC2(1), RAP1A(2), RAP1B(1), RAPGEF3(13), RAPGEF4(14), RASSF5(6), RHOA(1), RHOH(5), ROCK1(5), ROCK2(13), SIPA1(8), THY1(1), TXK(10), VASP(3), VAV1(16), VAV2(4), VAV3(10), VCAM1(18), VCL(7)	47811209	844	197	793	409	558	57	30	112	84	3	0.00130	1.000	1.000
113	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(3), APC(22), AR(7), BRAF(147), CAMP(1), CCL13(1), CCL15(3), CCL16(1), DAG1(6), EGFR(23), GNA11(7), GNA15(5), GNAI1(1), GNAQ(5), ITPKA(1), ITPKB(6), ITPR1(36), ITPR2(18), ITPR3(9), KCNJ3(22), KCNJ5(15), KCNJ9(4), MAPK1(4), MAPK10(9), MAPK14(5), PHKA2(7), PIK3CA(9), PIK3CD(7), PIK3R1(7), PITX2(4), PTX3(1), RAF1(8), SRC(1)	20569764	405	196	267	149	169	22	22	161	30	1	0.0137	1.000	1.000
114	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(17), AMY2A(5), AMY2B(10), ASCC3(11), ATP13A2(10), DDX18(4), DDX19A(1), DDX23(5), DDX4(11), DDX41(6), DDX47(1), DDX50(5), DDX51(5), DDX52(4), DDX54(2), DDX55(3), DDX56(3), DHX58(4), ENPP1(13), ENPP3(15), ENTPD7(2), EP400(25), ERCC2(2), ERCC3(5), G6PC(7), G6PC2(7), GAA(7), GANC(6), GBA(5), GBA3(14), GBE1(9), GCK(20), GPI(3), GUSB(4), GYS1(3), GYS2(22), HK1(3), HK2(12), HK3(15), IFIH1(13), MGAM(142), MOV10L1(28), NUDT5(2), NUDT8(1), PGM1(4), PGM3(4), PYGB(2), PYGL(9), PYGM(10), RAD54B(6), RUVBL2(4), SETX(17), SI(81), SKIV2L2(4), SMARCA2(11), SMARCA5(5), TREH(3), UGDH(1), UGP2(2), UGT1A1(5), UGT1A10(15), UGT1A3(12), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(12), UGT1A8(7), UGT1A9(11), UGT2A1(22), UGT2A3(24), UGT2B10(38), UGT2B11(22), UGT2B15(29), UGT2B28(26), UGT2B4(36), UGT2B7(21), UXS1(4)	47546062	963	194	899	420	659	81	39	88	95	1	0.000137	1.000	1.000
115	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(6), AKR1C1(3), AKR1C2(4), AKR1C3(12), AKR1C4(9), ALDH1A3(2), ALDH3A1(7), ALDH3B1(2), ALDH3B2(7), CYP1A1(10), CYP1A2(12), CYP1B1(2), CYP2B6(16), CYP2C18(26), CYP2C19(42), CYP2C8(31), CYP2C9(38), CYP2E1(13), CYP2F1(11), CYP2S1(10), CYP3A4(20), CYP3A43(16), CYP3A5(10), CYP3A7(21), DHDH(5), EPHX1(2), GSTA1(5), GSTA2(2), GSTA3(1), GSTA5(3), GSTK1(2), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTP1(2), GSTT1(1), MGST1(2), MGST2(2), MGST3(1), UGT1A1(5), UGT1A10(15), UGT1A3(12), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(12), UGT1A8(7), UGT1A9(11), UGT2A1(22), UGT2A3(24), UGT2B10(38), UGT2B11(22), UGT2B15(29), UGT2B28(26), UGT2B4(36), UGT2B7(21)	22138444	791	193	717	340	581	56	38	52	63	1	5.76e-09	1.000	1.000
116	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(3), AKT2(8), AKT3(4), BTK(17), CSF2(2), FCER1A(14), FCER1G(1), FYN(7), GAB2(4), GRB2(2), HRAS(4), IL13(2), IL3(3), IL4(1), IL5(4), INPP5D(37), KRAS(4), LAT(1), LCP2(10), LYN(7), MAP2K1(13), MAP2K2(4), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(4), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(2), MAPK13(5), MAPK14(5), MAPK3(1), MAPK8(2), MAPK9(7), MS4A2(10), NRAS(73), PDK1(2), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(7), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), PLCG1(9), PLCG2(25), PRKCA(11), PRKCD(4), PRKCE(6), RAC1(17), RAC2(1), RAF1(8), SOS1(9), SOS2(13), SYK(16), TNF(1), VAV1(16), VAV2(4), VAV3(10)	27933880	602	191	497	213	340	31	49	125	56	1	1.54e-06	1.000	1.000
117	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(18), CD14(5), CD19(7), CD1A(11), CD1B(13), CD1C(23), CD1D(8), CD1E(22), CD2(23), CD22(26), CD33(18), CD34(4), CD36(4), CD37(3), CD38(4), CD3D(5), CD3E(2), CD3G(1), CD4(6), CD44(6), CD5(7), CD55(4), CD59(1), CD8A(2), CD8B(8), CR1(54), CR2(33), CSF1(11), CSF1R(13), CSF2(2), CSF2RA(20), CSF3(5), CSF3R(8), DNTT(10), EPO(6), EPOR(1), FCER2(3), FCGR1A(6), FLT3(31), FLT3LG(2), GP5(4), GP9(6), GYPA(8), HLA-DRA(11), HLA-DRB1(4), HLA-DRB5(1), IL11(2), IL11RA(3), IL1A(4), IL1B(7), IL1R1(12), IL1R2(9), IL2RA(4), IL3(3), IL3RA(8), IL4(1), IL4R(14), IL5(4), IL5RA(14), IL6(2), IL6R(4), IL7(5), IL7R(33), IL9R(6), ITGA1(18), ITGA2(14), ITGA2B(11), ITGA3(7), ITGA4(38), ITGA5(25), ITGA6(8), ITGAM(21), ITGB3(12), KIT(10), KITLG(9), MME(21), MS4A1(8), TFRC(5), THPO(8), TNF(1), TPO(45)	31456854	866	190	812	398	625	48	33	67	93	0	0.000506	1.000	1.000
118	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(3), AKT2(8), AKT3(4), BCL10(3), BLNK(14), BTK(17), CARD11(35), CD19(7), CD22(26), CD72(4), CD79A(2), CD79B(1), CD81(2), CHP(3), CHUK(2), CR2(33), FCGR2B(3), FOS(2), GSK3B(2), HRAS(4), IKBKB(4), INPP5D(37), JUN(1), KRAS(4), LILRB3(6), LYN(7), MALT1(8), NFAT5(8), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB1(7), NFKB2(5), NFKBIA(2), NFKBIB(1), NRAS(73), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PLCG2(25), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(8), PTPN6(3), RAC1(17), RAC2(1), RASGRP3(15), SYK(16), VAV1(16), VAV2(4), VAV3(10)	28845067	606	190	513	214	344	30	55	119	57	1	9.43e-07	1.000	1.000
119	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(3), AKT3(4), BCAR1(5), CAPN1(4), CAPN10(8), CAPN11(11), CAPN2(6), CAPN3(9), CAPN5(7), CAPN6(14), CAPN7(2), CAPN9(13), CAPNS1(1), CAV1(2), CDC42(3), CRK(3), CSK(1), DOCK1(15), FYN(7), GIT2(9), GRB2(2), ITGA10(10), ITGA11(17), ITGA2(14), ITGA2B(11), ITGA3(7), ITGA4(38), ITGA5(25), ITGA6(8), ITGA7(25), ITGA8(36), ITGA9(14), ITGAD(26), ITGAE(19), ITGAL(24), ITGAM(21), ITGAV(9), ITGAX(20), ITGB1(4), ITGB2(14), ITGB3(12), ITGB4(22), ITGB5(7), ITGB6(12), ITGB7(6), ITGB8(17), MAP2K1(13), MAP2K2(4), MAP2K3(9), MAP2K6(3), MAPK10(9), MAPK12(2), MAPK4(18), MAPK6(6), MAPK7(4), MYLK2(13), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PDPK1(4), PIK3R2(5), PTK2(8), PXN(3), RAC1(17), RAC2(1), RAP1B(1), RAPGEF1(10), RHO(2), ROCK1(5), ROCK2(13), SDCCAG8(5), SEPP1(1), SHC1(3), SHC3(12), SORBS1(13), SOS1(9), SRC(1), TLN1(14), TNS1(9), VASP(3), VAV2(4), VAV3(10), VCL(7), ZYX(7)	51403789	826	190	791	370	562	54	31	107	71	1	9.30e-05	1.000	1.000
120	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(3), AKT2(8), AKT3(4), CASP9(3), CDC42(3), CHP(3), HRAS(4), KDR(45), KRAS(4), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK11(1), MAPK12(2), MAPK13(5), MAPK14(5), MAPK3(1), MAPKAPK2(5), MAPKAPK3(4), NFAT5(8), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NOS3(17), NRAS(73), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(7), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), PLCG1(9), PLCG2(25), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(8), PRKCA(11), PRKCG(14), PTGS2(11), PTK2(8), PXN(3), RAC1(17), RAC2(1), RAF1(8), SH2D2A(3), SHC2(7), SPHK1(1), SPHK2(7), SRC(1), VEGFA(7)	27897073	577	188	476	220	331	24	44	125	52	1	6.02e-05	1.000	1.000
121	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(11), ABCA10(21), ABCA12(66), ABCA13(67), ABCA2(9), ABCA3(18), ABCA4(51), ABCA5(9), ABCA6(27), ABCA7(12), ABCA8(32), ABCA9(21), ABCB1(41), ABCB10(5), ABCB11(46), ABCB4(19), ABCB5(40), ABCB6(2), ABCB7(6), ABCB8(3), ABCB9(6), ABCC1(12), ABCC10(12), ABCC11(18), ABCC12(24), ABCC2(10), ABCC3(28), ABCC4(11), ABCC5(8), ABCC6(27), ABCC8(39), ABCC9(60), ABCD2(18), ABCD3(10), ABCD4(1), ABCG1(11), ABCG2(7), ABCG4(7), ABCG5(6), ABCG8(17), CFTR(46), TAP1(2), TAP2(13)	45614185	899	186	857	525	609	72	31	97	90	0	0.0292	1.000	1.000
122	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(3), AKT2(8), AKT3(4), CASP8(9), CD14(5), CD40(4), CD80(5), CD86(21), CHUK(2), CXCL10(3), CXCL11(1), CXCL9(3), FOS(2), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(10), IFNA17(2), IFNA2(1), IFNA21(9), IFNA4(1), IFNA5(3), IFNA6(3), IFNA7(5), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IKBKB(4), IKBKE(12), IL12A(3), IL12B(4), IL1B(7), IL6(2), IL8(1), IRAK1(5), IRAK4(3), IRF3(4), IRF5(5), IRF7(7), JUN(1), LBP(9), LY96(4), MAP2K1(13), MAP2K2(4), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(4), MAP3K7(1), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(2), MAPK13(5), MAPK14(5), MAPK3(1), MAPK8(2), MAPK9(7), MYD88(3), NFKB1(7), NFKB2(5), NFKBIA(2), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), RAC1(17), RELA(5), RIPK1(1), SPP1(7), STAT1(4), TBK1(5), TICAM1(9), TIRAP(1), TLR1(11), TLR2(17), TLR3(10), TLR4(34), TLR5(19), TLR6(6), TLR7(16), TLR8(12), TLR9(14), TNF(1), TOLLIP(1), TRAF3(5), TRAF6(5)	34660442	588	186	552	261	376	36	29	91	55	1	0.000955	1.000	1.000
123	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(3), ADCY1(29), ADCY2(8), ADCY3(4), ADCY4(6), ADCY5(17), ADCY6(7), ADCY7(10), ADCY8(51), ADK(4), ADSL(7), ADSS(2), AK1(1), AK2(3), AK5(7), ALLC(9), AMPD1(31), AMPD2(5), AMPD3(22), APRT(3), ATIC(5), ATP1B1(1), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(6), ATP5G2(1), ATP5H(1), ATP5J(2), CANT1(9), DGUOK(4), ENPP1(13), ENPP3(15), ENTPD1(11), ENTPD2(4), FHIT(3), GART(10), GDA(13), GMPS(6), GUCY1A2(21), GUCY1A3(34), GUCY1B3(7), GUCY2C(32), GUCY2D(10), GUCY2F(16), GUK1(2), IMPDH1(2), IMPDH2(1), NPR1(18), NPR2(14), NT5E(4), NT5M(2), PAICS(1), PAPSS1(3), PAPSS2(5), PDE1A(37), PDE4A(9), PDE4B(7), PDE4C(18), PDE4D(8), PDE5A(8), PDE6B(15), PDE6C(27), PDE6G(2), PDE7B(17), PDE8A(3), PDE9A(10), PFAS(9), PKLR(11), PKM2(5), POLD1(6), POLD2(2), POLE(16), POLG(9), POLL(7), POLQ(25), POLR1B(9), POLR2A(12), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(2), PRPS1(2), PRPS1L1(14), PRPS2(4), PRUNE(2), RRM1(3), RRM2(2)	49500205	831	185	780	419	583	68	28	78	74	0	0.00176	1.000	1.000
124	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(12), ATM(13), BUB1(6), BUB1B(9), CCNA1(18), CCNB2(3), CCNB3(29), CCND2(5), CCND3(2), CCNE1(4), CCNE2(14), CCNH(2), CDAN1(5), CDC14A(5), CDC14B(1), CDC20(1), CDC25A(8), CDC25B(6), CDC25C(5), CDC6(1), CDC7(3), CDH1(7), CDK4(5), CDKN1A(4), CDKN2A(34), CHEK1(2), CHEK2(2), DTX4(4), E2F1(7), E2F2(4), E2F3(6), E2F4(1), E2F5(1), EP300(14), ESPL1(14), GSK3B(2), HDAC1(1), HDAC2(1), HDAC3(6), HDAC4(10), HDAC5(7), HDAC6(2), HDAC8(3), MAD1L1(5), MAD2L1(1), MAD2L2(1), MCM2(11), MCM3(10), MCM4(7), MCM5(4), MCM6(5), MDM2(4), MPEG1(7), MPL(8), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), PLK1(3), PRKDC(20), PTPRA(7), PTTG1(1), PTTG2(5), RB1(8), RBL1(11), SKP2(2), SMAD4(2), TBC1D8(9), TFDP1(3), TGFB1(1), TP53(43), WEE1(3)	42530976	485	183	446	179	267	39	25	78	74	2	0.000276	1.000	1.000
125	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(3), ACTB(7), ACTG1(5), ACTN1(5), ACTN2(24), ACTN3(7), ACTN4(5), ACVR1B(3), ACVR1C(9), BAIAP2(7), CDC42(3), CDH1(7), CREBBP(23), CSNK2A1(1), CSNK2A2(1), CSNK2B(2), CTNNA1(2), CTNNA2(27), CTNNA3(30), CTNNB1(13), CTNND1(9), EGFR(23), EP300(14), ERBB2(7), FARP2(6), FER(3), FGFR1(11), FYN(7), IGF1R(11), INSR(22), IQGAP1(10), LEF1(3), LMO7(27), MAP3K7(1), MAPK1(4), MAPK3(1), MET(23), MLLT4(13), NLK(6), PARD3(17), PTPN1(4), PTPN6(3), PTPRB(91), PTPRF(28), PTPRJ(12), PTPRM(8), PVRL1(4), PVRL2(6), PVRL3(5), PVRL4(7), RAC1(17), RAC2(1), RHOA(1), SMAD2(3), SMAD3(2), SMAD4(2), SNAI1(2), SNAI2(4), SORBS1(13), SRC(1), SSX2IP(5), TCF7(2), TCF7L1(3), TCF7L2(7), TGFBR2(7), TJP1(11), VCL(7), WAS(7), WASF1(5), WASF2(5), WASF3(12), WASL(5), YES1(5)	46547894	697	183	656	331	464	48	28	81	73	3	0.0899	1.000	1.000
126	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(28), ASH2L(3), CARM1(6), CTCFL(23), DOT1L(11), EED(4), EHMT1(8), EHMT2(9), EZH1(6), EZH2(14), FBXO11(6), HCFC1(17), HSF4(2), JMJD4(4), JMJD6(2), KDM6A(4), MEN1(4), MLL(40), MLL2(54), MLL3(66), MLL4(34), MLL5(12), NSD1(17), OGT(10), PAXIP1(4), PPP1CA(2), PPP1CB(5), PPP1CC(2), PRDM2(13), PRDM7(6), PRDM9(52), PRMT1(2), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), RBBP5(5), SATB1(14), SETD1A(24), SETD2(15), SETD7(3), SETD8(1), SETDB1(10), SETDB2(5), SETMAR(4), SMYD3(3), STK38(4), SUV39H1(1), SUV39H2(2), SUV420H1(8), SUV420H2(2), SUZ12(2), WHSC1(10), WHSC1L1(7)	45763017	607	182	583	212	388	58	23	80	58	0	0.00103	1.000	1.000
127	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(6), ALG1(2), ALG10(4), ALG10B(4), ALG12(1), ALG13(9), ALG14(2), ALG2(4), ALG3(4), ALG6(3), ALG8(6), ALG9(5), B3GNT1(2), B3GNT2(2), B3GNT7(4), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT4(3), B4GALT5(3), C1GALT1(6), C1GALT1C1(2), CHPF(4), CHST1(9), CHST11(5), CHST12(4), CHST13(3), CHST14(3), CHST2(4), CHST3(1), CHST4(11), CHST6(4), CHSY1(8), DAD1(1), DDOST(3), DPAGT1(2), EXT1(2), EXT2(6), EXTL1(2), EXTL3(11), FUT11(3), FUT8(8), GALNT1(4), GALNT10(6), GALNT11(3), GALNT12(9), GALNT13(29), GALNT14(27), GALNT2(6), GALNT3(3), GALNT4(6), GALNT5(9), GALNT6(17), GALNT7(5), GALNT8(24), GALNT9(5), GALNTL1(5), GALNTL2(23), GALNTL4(6), GALNTL5(14), GANAB(5), GCNT1(7), GCNT3(7), GCNT4(4), HS2ST1(1), HS3ST1(11), HS3ST2(8), HS3ST3A1(4), HS3ST3B1(2), HS3ST5(8), HS6ST1(3), HS6ST2(3), HS6ST3(16), MAN1A1(17), MAN1A2(6), MAN1B1(4), MAN1C1(8), MAN2A1(10), MGAT1(3), MGAT2(3), MGAT3(10), MGAT4A(8), MGAT4B(1), MGAT5(5), MGAT5B(10), NDST1(4), NDST2(2), NDST3(25), NDST4(50), OGT(10), RPN2(2), ST3GAL1(6), ST3GAL2(1), ST3GAL3(2), ST3GAL4(1), ST6GAL1(5), ST6GALNAC1(5), STT3B(7), WBSCR17(39), XYLT1(13), XYLT2(3)	42286215	713	180	679	385	481	58	31	72	71	0	0.0941	1.000	1.000
128	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(17), AMY2A(5), AMY2B(10), ENPP1(13), ENPP3(15), G6PC(7), GAA(7), GANAB(5), GBA3(14), GBE1(9), GCK(20), GPI(3), GUSB(4), GYS1(3), GYS2(22), HK1(3), HK2(12), HK3(15), MGAM(142), PGM1(4), PGM3(4), PYGB(2), PYGL(9), PYGM(10), SI(81), UCHL1(5), UCHL3(2), UGDH(1), UGT1A1(5), UGT1A10(15), UGT1A3(12), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(12), UGT1A8(7), UGT1A9(11), UGT2B15(29), UGT2B4(36), UXS1(4)	21954504	599	179	556	257	418	61	25	47	47	1	0.000243	1.000	1.000
129	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(4), ACVR1B(3), ACVRL1(9), AKT1(3), AURKB(2), BMPR1A(2), BMPR2(6), BUB1(6), CDKL1(5), CDKL2(2), CDS1(11), CDS2(4), CLK1(4), CLK2(6), COL4A3BP(4), CSNK2A1(1), CSNK2A2(1), CSNK2B(2), DGKA(4), DGKB(24), DGKD(11), DGKE(7), DGKG(18), DGKH(8), DGKQ(6), DGKZ(8), IMPA1(2), INPP1(2), INPP4A(6), INPP4B(4), INPP5A(4), INPPL1(15), ITPKA(1), ITPKB(6), MAP3K10(8), MOS(5), NEK1(9), NEK3(2), OCRL(5), PAK4(4), PIK3C2A(8), PIK3C2B(14), PIK3C2G(50), PIK3CA(9), PIK3CB(26), PIK3CG(25), PIM2(4), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), PLCD1(4), PLCG1(9), PLCG2(25), PLK3(4), PRKACA(4), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(11), PRKCD(4), PRKCE(6), PRKCG(14), PRKCH(11), PRKCQ(18), PRKCZ(6), PRKD1(3), PRKG1(13), RAF1(8), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), RPS6KA4(4), RPS6KB1(2), STK11(4), VRK1(1)	43478447	704	178	660	378	471	40	29	90	73	1	0.522	1.000	1.000
130	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(11), AGTR2(12), ATP8A1(22), AVPR1A(4), AVPR1B(9), AVPR2(1), BDKRB1(5), BDKRB2(10), BRS3(5), C3AR1(5), CCKAR(10), CCKBR(12), CCR1(10), CCR10(2), CCR2(17), CCR3(11), CCR4(8), CCR5(7), CCR6(3), CCR7(3), CCR8(6), CX3CR1(13), CXCR3(5), CXCR4(4), CXCR6(4), EDNRA(9), EDNRB(5), FPR1(20), FSHR(19), GALR1(5), GALR2(1), GALR3(2), GALT(2), GHSR(11), GNB2L1(3), GNRHR(2), GPR77(5), GRPR(5), LHCGR(27), MC2R(5), MC3R(7), MC4R(1), MC5R(7), NMBR(8), NPY1R(25), NPY2R(14), NPY5R(24), NTSR1(6), NTSR2(3), OPRD1(2), OPRK1(23), OPRL1(5), OPRM1(5), OXTR(5), PPYR1(12), SSTR1(11), SSTR2(6), SSTR3(12), SSTR4(4), TACR1(8), TACR2(8), TACR3(28), TRHR(21), TSHR(11)	20265740	576	177	545	396	398	52	23	60	43	0	0.00240	1.000	1.000
131	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA1(2), IMPA2(2), INPP1(2), INPP4A(6), INPP4B(4), INPP5A(4), INPP5B(6), INPPL1(15), IPMK(2), ISYNA1(2), ITGB1BP3(2), ITPK1(6), ITPKA(1), ITPKB(6), MINPP1(1), MIOX(3), OCRL(5), PI4KA(18), PI4KB(4), PIK3C3(3), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIP4K2A(5), PIP4K2B(3), PIP4K2C(3), PIP5K1A(6), PIP5K1B(20), PIP5K1C(8), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), PLCD1(4), PLCD3(3), PLCD4(4), PLCE1(53), PLCG1(9), PLCG2(25), PLCZ1(26), PTEN(23), SYNJ1(23), SYNJ2(16)	28562649	533	174	496	226	341	28	27	80	56	1	0.000502	1.000	1.000
132	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(9), AKR1D1(20), ARSD(3), ARSE(5), CARM1(6), CYP11B1(16), CYP11B2(14), CYP19A1(12), HEMK1(5), HSD11B1(11), HSD11B2(2), HSD17B12(2), HSD17B2(10), HSD17B3(6), HSD17B7(2), HSD3B1(10), HSD3B2(11), LCMT1(4), METTL2B(8), METTL6(3), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), SRD5A1(3), SRD5A2(7), STS(7), SULT1E1(16), SULT2A1(8), SULT2B1(7), UGT1A1(5), UGT1A10(15), UGT1A3(12), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(12), UGT1A8(7), UGT1A9(11), UGT2A1(22), UGT2A3(24), UGT2B10(38), UGT2B11(22), UGT2B15(29), UGT2B28(26), UGT2B4(36), UGT2B7(21), WBSCR22(1)	19310554	536	171	494	219	373	50	25	36	51	1	9.34e-07	1.000	1.000
133	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AIFM1(1), AKT1(3), AKT2(8), AKT3(4), APAF1(6), ATM(13), BAX(3), BCL2(2), BIRC2(5), BIRC3(8), CAPN1(4), CAPN2(6), CASP10(5), CASP3(2), CASP7(5), CASP8(9), CASP9(3), CFLAR(4), CHP(3), CHUK(2), CSF2RB(18), CYCS(1), DFFA(2), DFFB(3), FAS(5), FASLG(14), IKBKB(4), IL1A(4), IL1B(7), IL1R1(12), IL1RAP(4), IL3(3), IL3RA(8), IRAK1(5), IRAK2(14), IRAK3(7), IRAK4(3), MAP3K14(4), MYD88(3), NFKB1(7), NFKB2(5), NFKBIA(2), NTRK1(19), PIK3CA(9), PIK3CB(26), PIK3CD(7), PIK3CG(25), PIK3R1(7), PIK3R2(5), PIK3R3(2), PIK3R5(14), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(8), PRKACA(4), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RELA(5), RIPK1(1), TNF(1), TNFRSF10A(5), TNFRSF10B(3), TNFRSF10C(4), TNFRSF10D(8), TNFRSF1A(3), TNFSF10(8), TP53(43), TRAF2(3)	32196532	476	171	453	227	278	32	24	77	64	1	0.197	1.000	1.000
134	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(4), ACVR1B(3), ACVR1C(9), ACVR2A(3), ACVR2B(3), ACVRL1(9), AMHR2(16), BMP2(6), BMP4(3), BMP5(27), BMP6(11), BMP7(2), BMP8A(2), BMP8B(2), BMPR1A(2), BMPR1B(4), BMPR2(6), CHRD(14), COMP(7), CREBBP(23), CUL1(7), DCN(17), E2F4(1), E2F5(1), EP300(14), FST(4), GDF5(14), GDF6(2), GDF7(2), ID2(2), IFNG(2), INHBA(19), INHBB(8), INHBC(11), INHBE(3), LEFTY1(8), LEFTY2(3), LTBP1(45), MAPK1(4), MAPK3(1), MYC(5), NODAL(2), NOG(1), PITX2(4), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(4), PPP2R2A(2), PPP2R2B(6), PPP2R2C(6), RBL1(11), RBL2(6), RHOA(1), ROCK1(5), ROCK2(13), RPS6KB1(2), RPS6KB2(3), SMAD1(6), SMAD2(3), SMAD3(2), SMAD4(2), SMAD5(3), SMAD6(7), SMAD7(3), SMAD9(10), SMURF1(1), SMURF2(9), SP1(5), TFDP1(3), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(7), THBS1(30), THBS2(10), THBS3(11), THBS4(11), TNF(1), ZFYVE16(4), ZFYVE9(8)	38421037	541	171	523	260	355	47	21	63	55	0	0.255	1.000	1.000
135	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(62), COL4A2(33), COL4A3(41), COL4A4(97), COL4A5(56), COL4A6(35), F10(10), F11(15), F12(1), F2(9), F2R(7), F5(37), F8(46), F9(12), FGA(42), FGB(10), FGG(8), KLKB1(25), PROC(9), PROS1(13), SERPINC1(8), SERPING1(12)	17202012	588	171	552	183	449	40	22	48	29	0	0.0572	1.000	1.000
136	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(6), AGK(6), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPAT6(3), AKR1A1(3), AKR1B1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3), CEL(13), DAK(3), DGAT1(1), DGAT2(7), DGKA(4), DGKB(24), DGKD(11), DGKE(7), DGKG(18), DGKH(8), DGKI(26), DGKQ(6), DGKZ(8), GK(6), GK2(38), GLA(1), GLB1(8), GPAM(5), LCT(43), LIPA(4), LIPC(9), LIPF(15), LIPG(6), LPL(3), MGLL(6), PNLIP(8), PNLIPRP1(10), PNLIPRP2(3), PNPLA3(2), PPAP2B(9), PPAP2C(8)	22797805	508	169	458	222	351	48	18	57	34	0	0.000116	1.000	1.000
137	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(13), CCNA1(18), CCND1(1), CCND2(5), CCND3(2), CCNE1(4), CCNE2(14), CCNH(2), CDC25A(8), CDK4(5), CDKN1A(4), CDKN1B(1), CDKN2A(34), CDKN2C(1), CREB3(1), CREB3L1(6), CREB3L3(10), CREB3L4(5), E2F1(7), E2F2(4), E2F3(6), E2F4(1), E2F5(1), GBA2(2), MCM2(11), MCM3(10), MCM4(7), MCM5(4), MCM6(5), MDM2(4), MNAT1(2), MYC(5), MYT1(22), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), POLA2(9), POLE(16), POLE2(3), PRIM1(3), RB1(8), RBL1(11), RPA1(3), RPA2(2), RPA3(1), TFDP1(3), TFDP2(4), TNXB(143), TP53(43), WEE1(3)	30606044	492	167	447	183	286	31	19	80	74	2	0.000141	1.000	1.000
138	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(3), AKT2(8), AKT3(4), CDC42(3), CDKN1B(1), CDKN2A(34), CREB3(1), CREB5(11), ERBB4(50), F2RL2(6), GAB1(4), GRB2(2), GSK3B(2), IFI27(2), IGF1(11), IGFBP1(3), INPPL1(15), IRS1(6), IRS2(2), IRS4(12), MET(23), MYC(5), NOLC1(4), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PAK7(48), PARD3(17), PARD6A(2), PDK1(2), PIK3CA(9), PIK3CD(7), PPP1R13B(8), PREX1(7), PTEN(23), PTK2(8), PTPN1(4), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(3), SLC2A4(8), SOS1(9), SOS2(13), TSC1(5), TSC2(12), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3)	29941141	456	167	419	198	252	39	24	62	78	1	0.0464	1.000	1.000
139	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(6), ATM(13), ATR(25), BAI1(16), BAX(3), CASP3(2), CASP8(9), CASP9(3), CCNB2(3), CCNB3(29), CCND1(1), CCND2(5), CCND3(2), CCNE1(4), CCNE2(14), CCNG1(1), CDK4(5), CDK6(3), CDKN1A(4), CDKN2A(34), CHEK1(2), CHEK2(2), CYCS(1), DDB2(3), EI24(3), FAS(5), GADD45B(2), GADD45G(1), GTSE1(11), IGF1(11), IGFBP3(2), LRDD(5), MDM2(4), MDM4(2), PERP(2), PPM1D(2), PTEN(23), RFWD2(5), RPRM(1), RRM2(2), RRM2B(3), SERPINB5(8), SERPINE1(5), SESN2(7), SESN3(1), SFN(1), STEAP3(8), THBS1(30), TNFRSF10B(3), TP53(43), TP53I3(3), TP73(5), TSC2(12), ZMAT3(1)	25128087	401	166	361	146	209	24	27	60	80	1	0.00178	1.000	1.000
140	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(2), CDC40(4), CLK2(6), CLK3(4), COL2A1(30), CPSF1(7), CPSF2(2), CPSF3(5), CSTF1(5), CSTF2(4), CSTF2T(4), CSTF3(5), DDIT3(2), DDX1(2), DDX20(8), DHX15(4), DHX16(8), DHX38(9), DHX8(11), DHX9(9), DICER1(18), DNAJC8(2), GIPC1(5), LOC440563(24), LSM2(2), LSM7(1), METTL3(2), NCBP1(1), NONO(10), NUDT21(3), NXF1(5), PABPN1(1), PAPOLA(4), PHF5A(1), POLR2A(12), PPM1G(2), PRPF18(4), PRPF3(4), PRPF4(4), PRPF4B(5), PRPF8(14), PSKH1(2), PTBP1(1), PTBP2(7), RBM17(1), RBM5(9), RNGTT(3), RNMT(8), RNPS1(1), SF3A1(7), SF3A2(6), SF3A3(4), SF3B1(15), SF3B2(9), SF3B4(5), SF4(8), SFRS12(3), SFRS14(13), SFRS16(5), SFRS4(2), SFRS5(3), SFRS6(2), SFRS7(4), SFRS8(7), SFRS9(2), SNRPA(2), SNRPA1(2), SNRPB(5), SNRPB2(1), SNRPD1(1), SNRPE(2), SNRPN(6), SNURF(3), SPOP(2), SRPK1(8), SRPK2(2), SRRM1(10), SUPT5H(7), TXNL4A(1), U2AF2(4), XRN2(5)	41223267	443	165	433	198	270	38	23	60	52	0	0.581	1.000	1.000
141	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(6), ACADL(4), ACADM(6), ACOX1(7), ACOX2(7), ACOX3(13), ACSL1(6), ACSL3(6), ACSL4(2), ACSL5(23), ACSL6(14), ADIPOQ(3), ANGPTL4(4), APOA1(2), APOA5(6), AQP7(4), CD36(4), CPT1A(11), CPT1B(10), CPT1C(15), CPT2(1), CYP27A1(4), CYP4A11(28), CYP4A22(21), CYP7A1(9), CYP8B1(13), DBI(1), EHHADH(7), FABP1(7), FABP2(6), FABP3(1), FABP4(1), FABP5(1), FADS2(4), GK(6), GK2(38), HMGCS2(18), LPL(3), ME1(20), MMP1(12), NR1H3(3), OLR1(5), PCK1(23), PCK2(4), PDPK1(4), PLTP(1), PPARA(7), PPARD(3), PPARG(11), RXRA(4), RXRB(4), RXRG(5), SCD(3), SCP2(4), SLC27A1(3), SLC27A2(14), SLC27A4(4), SLC27A5(7), SLC27A6(29), SORBS1(13), UBC(6), UCP1(4)	25427837	515	164	484	270	370	41	18	44	41	1	0.0589	1.000	1.000
142	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(7), BCL2(2), CABIN1(11), CALM1(1), CALM2(1), CAMK2B(7), CAMK4(12), CD3E(2), CD3G(1), CD69(4), CDKN1A(4), CNR1(9), CREBBP(23), CSF2(2), CSNK2A1(1), CSNK2B(2), CTLA4(2), EGR2(4), EGR3(2), EP300(14), FCER1A(14), FCGR3A(9), FOS(2), GATA3(8), GATA4(3), GRLF1(12), GSK3B(2), HRAS(4), ICOS(3), IFNA1(1), IFNB1(6), IFNG(2), IL10(3), IL13(2), IL1B(7), IL2(4), IL2RA(4), IL3(3), IL4(1), IL6(2), IL8(1), ITK(21), KPNA5(1), MAP2K7(4), MAPK14(5), MAPK8(2), MAPK9(7), MEF2A(5), MEF2B(3), MEF2D(5), MYF5(16), NCK2(6), NFAT5(8), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB2(5), NFKBIB(1), NPPB(5), NUP214(14), OPRD1(2), P2RX7(5), PAK1(4), PIN1(1), PPIA(1), PPP3CB(4), PPP3CC(2), PPP3R1(1), PTPRC(33), RELA(5), RPL13A(2), SFN(1), SLA(2), SP1(5), SP3(1), TGFB1(1), TNF(1), TRAF2(3), TRPV6(31), VAV1(16), VAV2(4), VAV3(10), XPO5(7)	35262492	500	163	481	247	339	34	21	55	51	0	0.138	1.000	1.000
143	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(12), ALG6(3), CCKBR(12), CCR2(17), CCR3(11), CCR5(7), CELSR1(25), CELSR2(24), CELSR3(33), CHRM2(19), CHRM3(22), CXCR3(5), DRD4(1), EDNRA(9), EMR2(5), EMR3(18), F2R(7), FSHR(19), GHRHR(4), GNRHR(2), GPR116(34), GPR132(3), GPR133(14), GPR135(1), GPR143(3), GPR17(1), GPR18(6), GPR55(4), GPR56(4), GPR61(8), GPR77(5), GPR84(8), GRM1(17), GRPR(5), HRH4(5), LGR6(18), LPHN2(38), LPHN3(21), LTB4R2(1), NTSR1(6), OR2M4(13), OR8G2(17), P2RY13(4), PTGFR(22), SMO(11), SSTR2(6), TAAR5(4), TSHR(11)	25751507	545	163	522	347	358	48	23	72	43	1	0.124	1.000	1.000
144	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ABP1(20), ACAT2(1), ACMSD(10), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH9A1(3), AOC2(8), AOC3(8), AOX1(24), ASMT(7), CAT(6), CYP19A1(12), CYP1A1(10), CYP1A2(12), CYP2A13(12), CYP2A6(12), CYP2A7(8), CYP2B6(16), CYP2C18(26), CYP2C19(42), CYP2C8(31), CYP2C9(38), CYP2D6(2), CYP2E1(13), CYP2F1(11), CYP2J2(7), CYP3A4(20), CYP3A5(10), CYP3A7(21), CYP4B1(21), CYP4F8(15), CYP51A1(1), DDC(12), ECHS1(2), EHHADH(7), GCDH(5), HAAO(3), HADHA(8), KMO(8), KYNU(11), MAOA(4), MAOB(13), SDS(2), TDO2(5), TPH1(9), WARS(4), WARS2(4)	21245255	566	163	533	325	428	36	22	42	38	0	0.0648	1.000	1.000
145	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(3), AKT2(8), AKT3(4), BCR(11), BTK(17), CD19(7), CDKN2A(34), DAPP1(6), FLOT1(2), GAB1(4), ITPR1(36), ITPR2(18), ITPR3(9), LYN(7), NR0B2(6), PDK1(2), PIK3CA(9), PITX2(4), PLCG2(25), PPP1R13B(8), PREX1(7), PTEN(23), PTPRC(33), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), RPS6KB1(2), SAG(9), SYK(16), TEC(10), VAV1(16)	21314015	355	162	316	168	210	21	24	37	63	0	0.0220	1.000	1.000
146	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(4), BAX(3), BFAR(1), BTK(17), CAD(18), CASP10(5), CASP3(2), CASP8(9), CASP8AP2(9), CDK2AP1(2), CSNK1A1(3), DAXX(10), DEDD(1), DEDD2(3), DFFA(2), DIABLO(1), EGFR(23), EPHB2(31), FAF1(7), FAIM2(5), HSPB1(2), IL1A(4), IL8(1), MAP2K4(4), MAP2K7(4), MAP3K1(3), MAP3K5(18), MAPK1(4), MAPK10(9), MAPK8(2), MAPK8IP1(5), MAPK8IP2(9), MAPK8IP3(9), MAPK9(7), MET(23), NFAT5(8), NFKB1(7), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), NR0B2(6), PTPN13(13), RALBP1(2), RIPK1(1), ROCK1(5), SMPD1(3), TNFRSF6B(2), TP53(43), TPX2(11), TRAF2(3), TUFM(6)	28109202	385	161	366	191	226	26	23	53	57	0	0.404	1.000	1.000
147	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACSS2(4), ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(6), AKR1A1(3), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH7A1(10), ALDH9A1(3), ALDOA(2), ALDOB(13), ALDOC(3), BPGM(3), DLAT(2), DLD(2), ENO1(4), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(7), G6PC2(7), GALM(2), GAPDH(3), GAPDHS(1), GCK(20), GPI(3), HK1(3), HK2(12), HK3(15), LDHA(6), LDHAL6A(5), LDHAL6B(7), LDHB(2), LDHC(5), PDHA1(3), PDHA2(19), PDHB(1), PFKL(4), PFKM(2), PGAM2(3), PGK1(5), PGK2(29), PGM1(4), PGM3(4), PKLR(11), PKM2(5)	22545603	402	158	361	185	279	34	19	42	28	0	0.000248	1.000	1.000
148	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(11), ADCY4(6), ADCY6(7), ADCY8(51), CACNA1A(36), CACNA1B(28), GNAS(22), GNAT3(3), GNB3(7), GRM4(20), ITPR3(9), KCNB1(37), PDE1A(37), PLCB2(10), PRKACA(4), PRKACB(4), PRKACG(8), PRKX(4), SCNN1A(7), SCNN1B(14), SCNN1G(28), TAS1R1(10), TAS1R2(25), TAS1R3(3), TAS2R1(10), TAS2R10(7), TAS2R13(3), TAS2R14(2), TAS2R16(10), TAS2R3(1), TAS2R38(16), TAS2R39(10), TAS2R4(3), TAS2R40(4), TAS2R41(15), TAS2R42(2), TAS2R43(1), TAS2R46(2), TAS2R5(4), TAS2R50(1), TAS2R60(19), TAS2R7(3), TAS2R8(5), TAS2R9(7), TRPM5(13)	21908389	529	158	494	419	367	40	21	59	42	0	0.825	1.000	1.000
149	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(3), ACTR3(2), AKT1(3), AKT2(8), AKT3(4), ANGPTL2(3), ARHGAP1(2), ARHGAP4(3), ARHGEF11(19), BTK(17), CDC42(3), CFL1(1), GDI1(1), GDI2(2), INPPL1(15), ITPR1(36), ITPR2(18), ITPR3(9), LIMK1(4), MYLK(41), MYLK2(13), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PAK7(48), PDK1(2), PIK3CA(9), PIK3CD(7), PIK3CG(25), PIK3R1(7), PITX2(4), PPP1R13B(8), PTEN(23), RACGAP1(3), RHO(2), ROCK1(5), ROCK2(13), SAG(9), WASF1(5), WASL(5)	27071500	413	156	387	182	258	32	18	58	46	1	0.00642	1.000	1.000
150	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH6(11), ADH7(13), ADHFE1(6), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AKR1A1(3), AKR1B1(2), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH9A1(3), CEL(13), DGAT1(1), DGKA(4), DGKB(24), DGKD(11), DGKE(7), DGKG(18), DGKH(8), DGKQ(6), DGKZ(8), GK(6), GLA(1), GLB1(8), LCT(43), LIPC(9), LIPF(15), LIPG(6), LPL(3), PNLIP(8), PNLIPRP1(10), PNLIPRP2(3), PPAP2B(9), PPAP2C(8)	18702742	412	151	373	196	295	39	14	41	23	0	0.00411	1.000	1.000
151	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(5), AGT(6), AKT1(3), CALM1(1), CALM2(1), CALR(1), CAMK1(5), CAMK1G(11), CAMK4(12), CREBBP(23), CSNK1A1(3), EDN1(9), ELSPBP1(4), F2(9), FGF2(2), FKBP1A(2), GATA4(3), GSK3B(2), HAND1(2), HAND2(5), HRAS(4), IGF1(11), LIF(2), MAP2K1(13), MAPK1(4), MAPK14(5), MAPK3(1), MAPK8(2), MEF2C(3), MYH2(86), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NKX2-5(2), NPPA(3), PIK3CA(9), PIK3R1(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RAF1(8), RPS6KB1(2), SYT1(20)	19683721	371	151	342	202	258	28	17	37	30	1	0.484	1.000	1.000
152	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(6), ACAA2(2), ACADL(4), ACADM(6), ACADS(4), ACADSB(6), ACADVL(1), ACAT2(1), ACOX1(7), ACOX3(13), ACSL1(6), ACSL3(6), ACSL4(2), ACSL5(23), ACSL6(14), ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(6), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3), CPT1A(11), CPT1B(10), CPT1C(15), CPT2(1), CYP4A11(28), CYP4A22(21), DCI(2), ECHS1(2), EHHADH(7), GCDH(5), HADHA(8), HADHB(4), HSD17B10(2), HSD17B4(6), PECI(3)	19063088	382	150	350	164	278	30	19	30	24	1	0.000954	1.000	1.000
153	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(20), ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(6), ALDH1A3(2), ALDH3A1(7), ALDH3B1(2), ALDH3B2(7), AOC2(8), AOC3(8), AOX1(24), CARM1(6), COMT(3), DBH(14), DCT(3), DDC(12), ECH1(1), ESCO1(2), ESCO2(3), FAH(4), GOT1(6), GOT2(7), HEMK1(5), HGD(12), HPD(5), LCMT1(4), MAOA(4), MAOB(13), METTL2B(8), METTL6(3), MYST3(16), MYST4(16), NAT6(2), PNMT(4), PNPLA3(2), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), SH3GLB1(2), TAT(17), TH(9), TPO(45), TYR(8), TYRP1(8), WBSCR22(1)	23006209	466	149	435	229	341	37	24	41	23	0	0.0235	1.000	1.000
154	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(21), ACSL1(6), ACSL3(6), ACSL4(2), ACSL5(23), ACSL6(14), ADIPOQ(3), ADIPOR1(5), ADIPOR2(2), AGRP(1), AKT1(3), AKT2(8), AKT3(4), CAMKK1(3), CAMKK2(8), CD36(4), CHUK(2), CPT1A(11), CPT1B(10), CPT1C(15), CPT2(1), G6PC(7), G6PC2(7), IKBKB(4), IRS1(6), IRS2(2), IRS4(12), JAK1(6), JAK2(9), JAK3(7), LEP(2), LEPR(25), MAPK10(9), MAPK8(2), MAPK9(7), NFKB1(7), NFKB2(5), NFKBIA(2), NFKBIB(1), NPY(4), PCK1(23), PCK2(4), POMC(3), PPARA(7), PPARGC1A(22), PRKAA1(1), PRKAA2(26), PRKAB1(2), PRKAB2(2), PRKAG1(2), PRKAG2(9), PRKAG3(10), PRKCQ(18), PTPN11(10), RELA(5), RXRA(4), RXRB(4), RXRG(5), SLC2A1(4), SLC2A4(8), SOCS3(2), STAT3(11), STK11(4), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF2(3), TYK2(8)	32153004	480	149	460	267	302	49	23	51	55	0	0.503	1.000	1.000
155	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(12), ACTB(7), ACTG1(5), ARHGEF2(17), ARPC5(1), CD14(5), CDC42(3), CDH1(7), CLDN1(5), CTNNB1(13), CTTN(3), EZR(1), FYN(7), HCLS1(14), ITGB1(4), KRT18(4), LY96(4), NCK1(1), NCK2(6), NCL(6), OCLN(4), PRKCA(11), RHOA(1), ROCK1(5), ROCK2(13), TLR4(34), TLR5(19), TUBA1A(2), TUBA1B(4), TUBA1C(2), TUBA3C(22), TUBA3D(12), TUBA3E(4), TUBA4A(6), TUBA8(3), TUBAL3(13), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(5), TUBB4(4), TUBB4Q(10), TUBB6(10), TUBB8(15), WAS(7), WASL(5), YWHAQ(3)	20306342	346	149	332	135	223	37	12	39	35	0	6.43e-05	1.000	1.000
156	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(12), ACTB(7), ACTG1(5), ARHGEF2(17), ARPC5(1), CD14(5), CDC42(3), CDH1(7), CLDN1(5), CTNNB1(13), CTTN(3), EZR(1), FYN(7), HCLS1(14), ITGB1(4), KRT18(4), LY96(4), NCK1(1), NCK2(6), NCL(6), OCLN(4), PRKCA(11), RHOA(1), ROCK1(5), ROCK2(13), TLR4(34), TLR5(19), TUBA1A(2), TUBA1B(4), TUBA1C(2), TUBA3C(22), TUBA3D(12), TUBA3E(4), TUBA4A(6), TUBA8(3), TUBAL3(13), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(5), TUBB4(4), TUBB4Q(10), TUBB6(10), TUBB8(15), WAS(7), WASL(5), YWHAQ(3)	20306342	346	149	332	135	223	37	12	39	35	0	6.43e-05	1.000	1.000
157	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(8), AGT(6), AGTR1(11), AGTR2(12), CMA1(6), COL4A1(62), COL4A2(33), COL4A3(41), COL4A4(97), COL4A5(56), COL4A6(35), REN(9)	9771968	376	148	351	109	310	19	9	23	15	0	0.414	1.000	1.000
158	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(3), AKT2(8), AKT3(4), BCL2(2), BCR(11), BLNK(14), BTK(17), CD19(7), CD22(26), CD81(2), CR2(33), CSK(1), DAG1(6), FLOT1(2), GRB2(2), GSK3B(2), INPP5D(37), ITPR1(36), ITPR2(18), ITPR3(9), LYN(7), MAP4K1(9), MAPK1(4), MAPK3(1), NFATC1(15), NFATC2(9), NR0B2(6), PDK1(2), PIK3CA(9), PIK3CD(7), PIK3R1(7), PLCG2(25), PPP1R13B(8), PPP3CA(5), PPP3CB(4), PPP3CC(2), PTPRC(33), RAF1(8), SHC1(3), SOS1(9), SOS2(13), SYK(16), VAV1(16)	28607174	458	148	440	206	297	32	27	55	46	1	0.00340	1.000	1.000
159	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(3), AKT2(8), AKT3(4), BRD4(20), CAP1(1), CBL(11), CDC42(3), CDKN2A(34), F2RL2(6), FLOT1(2), GRB2(2), GSK3B(2), IGFBP1(3), INPPL1(15), IRS1(6), IRS2(2), IRS4(12), LNPEP(10), MAPK1(4), MAPK3(1), PARD3(17), PARD6A(2), PDK1(2), PIK3CA(9), PIK3CD(7), PIK3R1(7), PPYR1(12), PTEN(23), PTPN1(4), RAF1(8), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), RPS6KB1(2), SERPINB6(4), SFN(1), SHC1(3), SLC2A4(8), SORBS1(13), SOS1(9), SOS2(13), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3)	23123023	318	148	294	129	150	29	21	51	66	1	0.0930	1.000	1.000
160	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(3), ACP2(2), ACP5(3), ACPP(8), ACPT(1), ALPI(9), ALPL(9), ALPP(11), ALPPL2(12), CYP19A1(12), CYP1A1(10), CYP1A2(12), CYP2A13(12), CYP2A6(12), CYP2A7(8), CYP2B6(16), CYP2C18(26), CYP2C19(42), CYP2C8(31), CYP2C9(38), CYP2D6(2), CYP2E1(13), CYP2F1(11), CYP2J2(7), CYP3A4(20), CYP3A5(10), CYP3A7(21), CYP4B1(21), CYP4F8(15), CYP51A1(1), PON1(15)	11267482	413	147	381	239	322	23	14	23	31	0	0.00897	1.000	1.000
161	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(9), CAD(18), CANT1(9), CDA(2), CTPS(2), CTPS2(3), DCTD(2), DHODH(3), DPYD(61), DPYS(24), ENTPD1(11), ENTPD3(6), ENTPD4(4), ENTPD5(2), ENTPD6(5), ENTPD8(2), NME6(3), NME7(4), NT5C1A(3), NT5C1B(24), NT5C2(3), NT5C3(2), NT5E(4), NT5M(2), PNPT1(2), POLA1(2), POLA2(9), POLD1(6), POLD2(2), POLD3(4), POLE(16), POLE2(3), POLR1A(11), POLR1B(9), POLR1C(1), POLR2A(12), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(5), POLR3B(15), POLR3G(1), POLR3GL(1), POLR3H(2), POLR3K(1), PRIM1(3), PRIM2(15), RRM1(3), RRM2(2), RRM2B(3), TK2(1), TXNRD1(7), TXNRD2(3), TYMS(1), UCK1(2), UMPS(1), UPB1(6), UPP2(5), UPRT(1), ZNRD1(1)	31395481	385	147	364	199	250	33	18	53	31	0	0.301	1.000	1.000
162	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH6(11), ADH7(13), ADHFE1(6), AKR1A1(3), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH9A1(3), ALDOA(2), ALDOB(13), ALDOC(3), BPGM(3), DLAT(2), DLD(2), ENO1(4), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(7), GAPDH(3), GCK(20), GPI(3), HK1(3), HK2(12), HK3(15), LDHA(6), LDHB(2), LDHC(5), PDHA1(3), PDHA2(19), PDHB(1), PFKM(2), PGK1(5), PGM1(4), PGM3(4), PKLR(11), PKM2(5)	18926673	343	146	311	152	240	33	15	31	24	0	0.000141	1.000	1.000
163	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH6(11), ADH7(13), ADHFE1(6), AKR1A1(3), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH9A1(3), ALDOA(2), ALDOB(13), ALDOC(3), BPGM(3), DLAT(2), DLD(2), ENO1(4), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(7), GAPDH(3), GCK(20), GPI(3), HK1(3), HK2(12), HK3(15), LDHA(6), LDHB(2), LDHC(5), PDHA1(3), PDHA2(19), PDHB(1), PFKM(2), PGK1(5), PGM1(4), PGM3(4), PKLR(11), PKM2(5)	18926673	343	146	311	152	240	33	15	31	24	0	0.000141	1.000	1.000
164	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(1), APH1A(2), CREBBP(23), CTBP2(1), DLL1(4), DLL3(7), DLL4(7), DTX1(9), DTX2(3), DTX3(6), DTX3L(6), DTX4(4), DVL2(3), DVL3(7), EP300(14), HDAC1(1), HDAC2(1), HES1(2), JAG1(10), JAG2(8), LFNG(3), MAML1(4), MAML2(6), MAML3(9), MFNG(8), NCOR2(26), NCSTN(4), NOTCH1(5), NOTCH2(41), NOTCH3(23), NOTCH4(57), NUMB(6), NUMBL(5), PSEN1(1), PSEN2(2), PSENEN(1), PTCRA(3), RBPJ(4), RBPJL(3), SNW1(2)	26602352	332	146	326	173	198	32	11	66	25	0	0.726	1.000	1.000
165	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(5), AKT1(3), BDKRB2(10), CALM1(1), CALM2(1), CAV1(2), CHRM1(5), CHRNA1(5), FLT1(33), FLT4(27), KDR(45), NOS3(17), PDE2A(14), PDE3A(27), PDE3B(6), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKG1(13), PRKG2(16), RYR2(90), SLC7A1(3), SYT1(20), TNNI1(2)	15769998	368	146	347	212	261	27	11	33	35	1	0.298	1.000	1.000
166	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(5), ALAS1(1), ALAS2(5), BLVRA(3), BLVRB(1), COX10(6), COX15(4), CP(12), CPOX(4), EPRS(11), FECH(3), FTH1(3), FTMT(8), GUSB(4), HCCS(2), HMBS(2), HMOX1(1), HMOX2(2), MMAB(2), PPOX(3), UGT1A1(5), UGT1A10(15), UGT1A3(12), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(12), UGT1A8(7), UGT1A9(11), UGT2A1(22), UGT2A3(24), UGT2B10(38), UGT2B11(22), UGT2B15(29), UGT2B28(26), UGT2B4(36), UGT2B7(21), UROS(1)	16309776	387	145	358	149	269	33	19	23	42	1	8.07e-05	1.000	1.000
167	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(3), ATF2(5), CDC42(3), DLD(2), DUSP10(6), DUSP4(3), DUSP8(4), GAB1(4), GCK(20), IL1R1(12), JUN(1), MAP2K4(4), MAP2K5(3), MAP2K7(4), MAP3K1(3), MAP3K10(8), MAP3K11(6), MAP3K12(4), MAP3K13(10), MAP3K2(6), MAP3K3(6), MAP3K4(16), MAP3K5(18), MAP3K7(1), MAP3K9(24), MAPK10(9), MAPK7(4), MAPK8(2), MAPK9(7), MYEF2(4), NFATC3(9), NR2C2(2), PAPPA(59), SHC1(3), TP53(43), TRAF6(5), ZAK(7)	19476697	330	145	309	125	216	30	12	33	38	1	0.0158	1.000	1.000
168	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(6), BMP4(3), BMP5(27), BMP6(11), BMP7(2), BMP8A(2), BMP8B(2), BTRC(5), CSNK1A1(3), CSNK1A1L(6), CSNK1D(1), CSNK1E(4), CSNK1G1(4), CSNK1G2(2), CSNK1G3(3), DHH(1), FBXW11(5), GLI1(16), GLI2(38), GLI3(17), GSK3B(2), HHIP(22), IHH(4), LRP2(94), PRKACA(4), PRKACB(4), PRKACG(8), PRKX(4), PTCH1(10), PTCH2(18), RAB23(1), SHH(5), SMO(11), STK36(14), SUFU(3), WNT1(2), WNT10A(7), WNT10B(5), WNT11(4), WNT16(1), WNT2(7), WNT2B(5), WNT3(6), WNT3A(6), WNT4(2), WNT5A(5), WNT5B(5), WNT6(2), WNT7A(14), WNT7B(6), WNT8A(7), WNT8B(7), WNT9A(3), WNT9B(3), ZIC2(2)	23334315	461	144	437	219	319	38	22	45	37	0	0.0114	1.000	1.000
169	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(22), AXIN1(11), CCND1(1), CCND2(5), CCND3(2), CSNK1E(4), CTNNB1(13), DVL2(3), DVL3(7), FBXW2(2), FZD1(4), FZD10(2), FZD2(5), FZD5(2), FZD6(2), FZD7(4), FZD8(6), FZD9(1), GSK3B(2), JUN(1), LDLR(16), MAPK10(9), MAPK9(7), MYC(5), PAFAH1B1(4), PLAU(3), PPP2R5C(5), PPP2R5E(4), PRKCA(11), PRKCD(4), PRKCE(6), PRKCG(14), PRKCH(11), PRKCI(8), PRKCQ(18), PRKCZ(6), PRKD1(3), RAC1(17), RHOA(1), SFRP4(6), TCF7(2), WNT1(2), WNT10A(7), WNT10B(5), WNT11(4), WNT16(1), WNT2(7), WNT2B(5), WNT3(6), WNT4(2), WNT5A(5), WNT5B(5), WNT6(2), WNT7A(14), WNT7B(6)	23085615	330	144	314	178	213	31	11	38	37	0	0.251	1.000	1.000
170	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(6), CALR(1), CANX(1), CD4(6), CD74(6), CD8A(2), CD8B(8), CIITA(17), CTSB(2), CTSL1(2), CTSS(7), HLA-A(3), HLA-B(5), HLA-C(1), HLA-DMA(4), HLA-DMB(7), HLA-DOA(5), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(7), HLA-DQB1(5), HLA-DRA(11), HLA-DRB1(4), HLA-DRB5(1), HLA-E(1), HLA-F(6), HLA-G(4), HSP90AA1(3), HSP90AB1(6), HSPA5(5), IFI30(2), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(10), IFNA17(2), IFNA2(1), IFNA21(9), IFNA4(1), IFNA5(3), IFNA6(3), IFNA7(5), IFNA8(3), KIR2DL1(21), KIR2DL3(6), KIR2DL4(4), KIR2DS4(16), KIR3DL1(18), KIR3DL2(2), KIR3DL3(9), KLRC1(5), KLRC2(1), KLRC3(11), KLRC4(5), KLRD1(5), LGMN(6), LTA(2), NFYA(2), NFYB(3), NFYC(2), PDIA3(4), PSME2(4), RFX5(5), RFXANK(1), RFXAP(1), TAP1(2), TAP2(13), TAPBP(2)	17815488	345	142	334	184	228	34	14	39	30	0	0.143	1.000	1.000
171	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(6), BAX(3), BCL2(2), BCL2L11(5), BIRC2(5), BIRC3(8), BIRC5(1), BNIP3L(2), CASP1(5), CASP10(5), CASP2(1), CASP3(2), CASP4(1), CASP7(5), CASP8(9), CASP9(3), CHUK(2), CYCS(1), DFFA(2), DFFB(3), FAS(5), FASLG(14), GZMB(3), HELLS(5), IKBKB(4), IRF1(1), IRF2(5), IRF3(4), IRF4(3), IRF5(5), IRF6(16), IRF7(7), JUN(1), LTA(2), MAP2K4(4), MAP3K1(3), MAPK10(9), MDM2(4), MYC(5), NFKB1(7), NFKBIA(2), NFKBIB(1), PLEKHG5(13), PRF1(13), RELA(5), RIPK1(1), TNF(1), TNFRSF10B(3), TNFRSF1A(3), TNFRSF1B(3), TNFRSF21(10), TNFRSF25(5), TNFSF10(8), TP53(43), TP73(5), TRAF1(6), TRAF2(3), TRAF3(5)	22141310	308	140	295	144	197	30	17	29	35	0	0.110	1.000	1.000
172	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(3), AKT2(8), AKT3(4), BCR(11), BLNK(14), BTK(17), CD19(7), CSK(1), DAG1(6), EPHB2(31), GRB2(2), ITPKA(1), ITPKB(6), LYN(7), MAP2K1(13), MAP2K2(4), MAPK1(4), NFAT5(8), NFKB1(7), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PI3(6), PIK3CA(9), PIK3CD(7), PIK3R1(7), PLCG2(25), PPP1R13B(8), RAF1(8), SERPINA4(16), SHC1(3), SOS1(9), SOS2(13), SYK(16), VAV1(16)	20456119	312	140	296	160	195	22	17	45	32	1	0.305	1.000	1.000
173	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(10), F11(15), F12(1), F13B(24), F2(9), F5(37), F7(9), F8(46), F9(12), FGA(42), FGB(10), FGG(8), LPA(53), PLAT(4), PLAU(3), PLG(33), SERPINB2(19), SERPINE1(5), SERPINF2(8), VWF(51)	13601051	399	139	375	164	282	30	23	29	34	1	0.0128	1.000	1.000
174	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(4), UGDH(1), UGP2(2), UGT1A1(5), UGT1A10(15), UGT1A3(12), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(12), UGT1A8(7), UGT1A9(11), UGT2A1(22), UGT2A3(24), UGT2B10(38), UGT2B11(22), UGT2B15(29), UGT2B28(26), UGT2B4(36), UGT2B7(21), XYLB(5)	10526835	318	139	290	127	225	26	15	18	33	1	0.000904	1.000	1.000
175	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(12), ALOX12(5), ALOX12B(13), ALOX15(9), ALOX15B(10), ALOX5(9), CBR3(1), CYP2B6(16), CYP2C18(26), CYP2C19(42), CYP2C8(31), CYP2C9(38), CYP2E1(13), CYP2J2(7), CYP2U1(1), CYP4A11(28), CYP4A22(21), CYP4F2(12), CYP4F3(20), EPHX2(4), GGT1(7), GPX1(3), GPX3(3), GPX5(13), GPX6(16), LTA4H(4), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(7), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), PTGDS(2), PTGES2(2), PTGIS(12), PTGS1(17), PTGS2(11), TBXAS1(14)	14972790	486	139	454	317	388	28	6	29	34	1	0.252	1.000	1.000
176	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(11), CD28(1), CD3D(5), CSK(1), CTLA4(2), DAG1(6), EPHB2(31), FBXW7(12), GRAP2(5), GRB2(2), ITK(21), ITPKA(1), ITPKB(6), LAT(1), LCK(14), LCP2(10), MAPK1(4), NCK1(1), NFAT5(8), NFKB1(7), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PAK7(48), PLCG1(9), PTPRC(33), RAF1(8), RASGRP1(9), RASGRP2(7), RASGRP3(15), RASGRP4(11), SOS1(9), SOS2(13), VAV1(16), ZAP70(7)	21463893	380	139	363	181	238	30	19	52	41	0	0.142	1.000	1.000
177	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(62), COL4A2(33), COL4A3(41), COL4A4(97), COL4A5(56), COL4A6(35), P4HB(3), SLC23A1(5), SLC23A2(4), SLC2A1(4), SLC2A3(8)	9660609	348	139	326	92	287	17	10	21	13	0	0.0689	1.000	1.000
178	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(2), INPP1(2), INPP4A(6), INPP4B(4), INPP5A(4), INPPL1(15), ITPKA(1), ITPKB(6), MIOX(3), OCRL(5), PIK3C2A(8), PIK3C2B(14), PIK3C2G(50), PIK3CA(9), PIK3CB(26), PIK3CG(25), PLCB1(52), PLCB2(10), PLCB3(6), PLCB4(73), PLCD1(4), PLCG1(9), PLCG2(25)	17271843	359	138	326	156	242	17	17	46	36	1	0.00631	1.000	1.000
179	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(5), ACTG2(5), ACTR2(3), ACTR3(2), AKT1(3), ANGPTL2(3), CDC42(3), CFL1(1), FLNA(15), FLNC(60), FSCN1(4), FSCN2(2), FSCN3(10), GDI1(1), GDI2(2), LIMK1(4), MYH2(86), MYLK(41), MYLK2(13), PAK1(4), PAK2(8), PAK3(11), PAK4(4), PAK6(4), PAK7(48), RHO(2), ROCK1(5), ROCK2(13), VASP(3), WASF1(5), WASL(5)	18472972	375	138	345	206	261	46	9	36	23	0	0.0688	1.000	1.000
180	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(1), CALM2(1), CAMK1(5), CAMK1G(11), ELK1(2), FPR1(20), GNA15(5), HRAS(4), MAP2K1(13), MAP2K2(4), MAP2K3(9), MAP2K6(3), MAP3K1(3), MAPK1(4), MAPK14(5), MAPK3(1), NCF1(1), NCF2(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB1(7), NFKBIA(2), PAK1(4), PIK3C2G(50), PLCB1(52), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAC1(17), RAF1(8), RELA(5), SYT1(20)	14743132	321	137	283	134	229	17	12	32	31	0	0.0120	1.000	1.000
181	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(5), AKT1(3), APC(22), CAMP(1), DAG1(6), DLG4(6), EPHB2(31), GNAI1(1), GNAQ(5), ITPR1(36), ITPR2(18), ITPR3(9), KCNJ3(22), KCNJ5(15), KCNJ9(4), MAPK1(4), PITX2(4), PTX3(1), RAC1(17), RHO(2), RYR1(93)	17637343	305	137	286	187	214	26	13	27	25	0	0.326	1.000	1.000
182	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(5), C1QB(5), C1R(14), C1S(20), C2(16), C3(49), C5(16), C6(66), C7(52), C8A(40), C8B(48), C9(22), MASP1(9)	7985113	362	136	318	141	277	19	10	31	24	1	0.000104	1.000	1.000
183	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(7), ADAM17(1), ATP6AP1(2), ATP6V0A1(9), ATP6V0A2(5), ATP6V0A4(20), ATP6V0D2(8), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C2(9), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), CASP3(2), CDC42(3), CHUK(2), CSK(1), EGFR(23), F11R(5), GIT1(4), HBEGF(1), IGSF5(11), IKBKB(4), IL8(1), JAM2(10), JAM3(2), JUN(1), LYN(7), MAP2K4(4), MAP3K14(4), MAPK10(9), MAPK11(1), MAPK12(2), MAPK13(5), MAPK14(5), MAPK8(2), MAPK9(7), MET(23), NFKB1(7), NFKB2(5), NFKBIA(2), NOD1(6), PAK1(4), PLCG1(9), PLCG2(25), PTPN11(10), PTPRZ1(24), RAC1(17), RELA(5), SRC(1), TCIRG1(3), TJP1(11)	27275166	359	136	345	207	226	32	18	54	29	0	0.768	1.000	1.000
184	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(5), AANAT(1), ABP1(20), ACAT2(1), ACMSD(10), AFMID(3), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3), AOC2(8), AOC3(8), AOX1(24), ASMT(7), CARM1(6), CAT(6), CYP1A1(10), CYP1A2(12), CYP1B1(2), DDC(12), ECHS1(2), EHHADH(7), GCDH(5), HAAO(3), HADHA(8), HEMK1(5), HSD17B10(2), HSD17B4(6), INMT(10), KMO(8), KYNU(11), LCMT1(4), LNX1(19), MAOA(4), MAOB(13), METTL2B(8), METTL6(3), NFX1(7), OGDH(11), OGDHL(41), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), TDO2(5), TPH1(9), TPH2(16), WARS(4), WARS2(4), WBSCR22(1)	23433597	412	135	394	207	289	33	19	46	25	0	0.0449	1.000	1.000
185	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(5), CRK(3), CRKL(2), DOCK1(15), ELK1(2), FOS(2), GAB1(4), GRB2(2), HGF(24), HRAS(4), ITGA1(18), ITGB1(4), JUN(1), MAP2K1(13), MAP2K2(4), MAP4K1(9), MAPK1(4), MAPK3(1), MAPK8(2), MET(23), PAK1(4), PIK3CA(9), PIK3R1(7), PTEN(23), PTK2(8), PTK2B(11), PTPN11(10), PXN(3), RAF1(8), RAP1A(2), RAP1B(1), RASA1(4), SOS1(9), SRC(1), STAT3(11)	16920544	253	133	235	106	142	18	12	41	39	1	0.315	1.000	1.000
186	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(5), C1QB(5), C1R(14), C1S(20), C2(16), C3(49), C5(16), C6(66), C7(52), C8A(40), C9(22), MASP1(9), MASP2(9), MBL2(13)	8183744	336	132	296	131	258	17	6	29	25	1	0.000183	1.000	1.000
187	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(20), ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH6(11), ADH7(13), ADHFE1(6), ALDH1A3(2), ALDH3A1(7), ALDH3B1(2), ALDH3B2(7), AOC2(8), AOC3(8), AOX1(24), COMT(3), DBH(14), DCT(3), DDC(12), FAH(4), GOT1(6), GOT2(7), HGD(12), HPD(5), MAOA(4), MAOB(13), PNMT(4), TAT(17), TH(9), TPO(45), TYR(8)	12238967	360	132	331	173	279	26	17	21	17	0	0.000844	1.000	1.000
188	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(13), BMPR1B(4), CCND2(5), CDK4(5), CDKN1B(1), DAZL(4), DMC1(10), EGR1(4), ESR2(8), FSHR(19), GJA4(4), INHA(4), LHCGR(27), MLH1(6), MSH5(16), NCOR1(20), NR5A1(7), NRIP1(9), PGR(15), PRLR(30), PTGER2(6), SMPD1(3), VDR(3), ZP2(14)	13514812	237	131	216	119	160	16	7	27	27	0	0.514	1.000	1.000
189	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(49), B3GALT4(2), CDR1(15), DGKI(26), IL6ST(10), MRPL19(1), PIGK(6), RPL10(4), RPL11(2), RPL13A(2), RPL14(1), RPL15(2), RPL18(3), RPL18A(1), RPL19(1), RPL21(1), RPL22(2), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL38(1), RPL39(1), RPL3L(3), RPL4(5), RPL5(6), RPL6(1), RPL7(2), RPL7A(1), RPLP0(1), RPLP2(1), RPS10(1), RPS11(1), RPS13(1), RPS15(1), RPS16(1), RPS18(1), RPS2(2), RPS20(2), RPS23(1), RPS24(1), RPS27(1), RPS27A(2), RPS29(1), RPS3A(1), RPS4Y1(1), RPS5(2), RPS6(1), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), RPS6KA6(16), RPS6KB1(2), RPS6KB2(3), RPS7(4), RPS8(1), RPSA(2), SLC36A2(8), TBC1D10C(5), TSPAN9(4), UBB(1), UBC(6)	20113629	253	131	242	147	157	24	15	34	23	0	0.736	1.000	1.000
190	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(20), AGMAT(3), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH4A1(6), ALDH9A1(3), AOC2(8), AOC3(8), ARG1(2), ARG2(1), ASL(6), CKM(2), CKMT1A(1), CKMT2(5), CPS1(22), DAO(10), GAMT(4), GATM(5), GLUD1(2), GOT1(6), GOT2(7), MAOA(4), MAOB(13), NOS1(65), NOS3(17), OAT(3), ODC1(3), OTC(3), P4HA1(9), P4HA2(5), P4HA3(13), P4HB(3), PYCR1(2), RARS(7), SMS(6)	17055310	315	130	301	177	209	37	16	23	30	0	0.214	1.000	1.000
191	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(6), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPAT6(3), CDS1(11), CDS2(4), CHAT(15), CHKA(2), CHKB(3), CHPT1(1), CRLS1(1), DGKA(4), DGKB(24), DGKD(11), DGKE(7), DGKG(18), DGKH(8), DGKI(26), DGKQ(6), DGKZ(8), ESCO1(2), ESCO2(3), ETNK1(4), GNPAT(2), GPAM(5), GPD1(9), GPD1L(3), GPD2(2), LYPLA1(1), LYPLA2(1), MYST3(16), MYST4(16), NAT6(2), PCYT1A(3), PCYT1B(8), PEMT(2), PISD(2), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(7), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), PLD1(12), PLD2(7), PNPLA3(2), PPAP2B(9), PPAP2C(8), PTDSS2(2), SH3GLB1(2)	25297408	363	130	343	203	234	32	13	48	36	0	0.632	1.000	1.000
192	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(2), AKT1(3), AKT2(8), AKT3(4), BTK(17), CDKN2A(34), DAPP1(6), GRB2(2), GSK3B(2), IARS(8), IGFBP1(3), INPP5D(37), PDK1(2), PIK3CA(9), PPP1R13B(8), PTEN(23), RPS6KA1(9), RPS6KA2(8), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(3), SOS1(9), SOS2(13), TEC(10), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3)	13963791	231	130	201	65	121	13	19	27	51	0	0.000286	1.000	1.000
193	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(6), ACAA2(2), ACAD8(1), ACAD9(1), ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(6), AKR1B10(8), AKR1C4(9), AKR1D1(20), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3), BAAT(12), CEL(13), CYP27A1(4), CYP7A1(9), HADHB(4), HSD3B7(3), LIPA(4), RDH11(2), RDH12(2), RDH13(3), SLC27A5(7), SOAT1(3), SOAT2(6), SRD5A1(3), SRD5A2(7)	12310868	285	129	255	128	190	31	20	26	18	0	0.00299	1.000	1.000
194	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(9), ABP1(20), ACADL(4), ACADM(6), ACADSB(6), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH9A1(3), AOC2(8), AOC3(8), CNDP1(9), DPYD(61), DPYS(24), ECHS1(2), EHHADH(7), GAD1(15), GAD2(10), HADHA(8), MLYCD(3), SDS(2), SMS(6), UPB1(6)	11270832	258	128	242	121	172	23	12	32	19	0	0.0542	1.000	1.000
195	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(17), CALM1(1), CALM2(1), ELK1(2), FCER1A(14), FCER1G(1), FOS(2), GRB2(2), HRAS(4), JUN(1), LYN(7), MAP2K1(13), MAP2K4(4), MAP2K7(4), MAP3K1(3), MAPK1(4), MAPK3(1), MAPK8(2), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PAK2(8), PIK3CA(9), PIK3R1(7), PLA2G4A(11), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAF1(8), SHC1(3), SOS1(9), SYK(16), SYT1(20), VAV1(16)	16626713	256	128	240	117	165	13	14	38	25	1	0.361	1.000	1.000
196	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(9), AKR1D1(20), ARSB(1), ARSD(3), ARSE(5), CYP11B1(16), CYP11B2(14), HSD11B1(11), HSD11B2(2), HSD17B2(10), HSD17B3(6), HSD3B1(10), HSD3B2(11), SRD5A1(3), SRD5A2(7), STS(7), SULT1E1(16), SULT2A1(8), UGT1A1(5), UGT1A10(15), UGT1A3(12), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(12), UGT1A8(7), UGT1A9(11), UGT2B15(29), UGT2B4(36)	10551243	310	127	284	139	212	32	17	19	29	1	0.000973	1.000	1.000
197	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(6), AGTR2(12), CALM1(1), CALM2(1), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CDK5(4), F2(9), FYN(7), GNA11(7), GNAI1(1), GRB2(2), HRAS(4), JAK2(9), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK14(5), MAPK3(1), MAPK8(2), MAPT(12), MYLK(41), PLCG1(9), PRKCA(11), PTK2B(11), RAF1(8), SHC1(3), SOS1(9), STAT1(4), STAT3(11), STAT5A(3), SYT1(20)	16061825	256	127	233	147	164	22	12	35	23	0	0.652	1.000	1.000
198	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), AKR1B10(8), B4GALT1(2), B4GALT2(2), G6PC(7), G6PC2(7), GAA(7), GALE(1), GALK1(1), GALK2(3), GALT(2), GANC(6), GCK(20), GLA(1), GLB1(8), HK1(3), HK2(12), HK3(15), HSD3B7(3), LALBA(7), LCT(43), MGAM(142), PFKL(4), PFKM(2), PGM1(4), PGM3(4), RDH11(2), RDH12(2), RDH13(3), UGP2(2)	14921618	325	127	305	178	236	29	7	30	23	0	0.0550	1.000	1.000
199	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(49), C5(16), C6(66), C7(52), ICAM1(3), IL1A(4), IL6(2), IL8(1), ITGA4(38), ITGAL(24), ITGB1(4), ITGB2(14), SELP(31), SELPLG(8), TNF(1), VCAM1(18)	9542594	331	127	297	134	243	11	16	27	33	1	0.000409	1.000	1.000
200	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(18), CANT1(9), CDA(2), CTPS(2), CTPS2(3), DCTD(2), DHODH(3), DPYD(61), DPYS(24), ENTPD1(11), NT5E(4), NT5M(2), POLD1(6), POLD2(2), POLE(16), POLG(9), POLL(7), POLQ(25), POLR1B(9), POLR2A(12), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(2), RRM1(3), RRM2(2), TK2(1), TXNRD1(7), TYMS(1), UCK1(2), UMPS(1), UNG(3), UPB1(6)	22225332	276	127	257	126	176	24	12	39	25	0	0.0510	1.000	1.000
201	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(5), C1QB(5), C1R(14), C1S(20), C2(16), C3(49), C5(16), C6(66), C7(52), C8A(40), C9(22)	6707371	305	126	267	116	233	14	6	28	23	1	0.000273	1.000	1.000
202	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(2), ALDOB(13), ALDOC(3), DLAT(2), DLD(2), ENO1(4), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(7), GAPDH(3), GAPDHS(1), GCK(20), GOT1(6), GOT2(7), GPI(3), HK1(3), HK2(12), HK3(15), LDHA(6), LDHAL6B(7), LDHB(2), LDHC(5), MDH1(1), MDH2(4), PC(13), PCK1(23), PDHA1(3), PDHA2(19), PDHB(1), PDHX(2), PFKL(4), PFKM(2), PGAM2(3), PGK1(5), PGK2(29), PKLR(11), PKM2(5), TNFAIP1(1)	16478667	261	126	243	129	187	21	12	21	20	0	0.00313	1.000	1.000
203	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(8), ALOX15(9), ALOX5(9), CYP1A2(12), CYP2C18(26), CYP2C19(42), CYP2C8(31), CYP2C9(38), CYP2E1(13), CYP2J2(7), CYP3A4(20), CYP3A43(16), CYP3A5(10), CYP3A7(21), HSD3B7(3), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(7), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), RDH11(2), RDH12(2), RDH13(3)	9247613	336	126	312	195	264	14	9	19	30	0	0.0826	1.000	1.000
204	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), CALM2(1), DLG4(6), GRIN1(7), GRIN2A(91), GRIN2B(56), GRIN2C(8), GRIN2D(6), NOS1(65), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(11), SYT1(20)	9860712	306	126	283	194	228	29	6	20	23	0	0.338	1.000	1.000
205	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(1), CALM2(1), CD3D(5), CD3E(2), CD3G(1), ELK1(2), FOS(2), FYN(7), GRB2(2), HRAS(4), JUN(1), LAT(1), LCK(14), MAP2K1(13), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(2), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB1(7), NFKBIA(2), PIK3CA(9), PIK3R1(7), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(11), PTPN7(3), RAC1(17), RAF1(8), RASA1(4), RELA(5), SHC1(3), SOS1(9), SYT1(20), VAV1(16), ZAP70(7)	18478450	260	125	236	111	170	21	11	34	23	1	0.136	1.000	1.000
206	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(6), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPS(5), CDS1(11), CDS2(4), CHAT(15), CHKA(2), CHKB(3), CLC(3), CPT1B(10), DGKA(4), DGKB(24), DGKD(11), DGKE(7), DGKG(18), DGKH(8), DGKQ(6), DGKZ(8), ETNK1(4), GNPAT(2), GPD1(9), GPD2(2), LGALS13(4), LYPLA1(1), LYPLA2(1), PAFAH1B1(4), PAFAH2(2), PCYT1A(3), PCYT1B(8), PEMT(2), PISD(2), PLA2G1B(1), PLA2G2A(2), PLA2G2E(4), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), PLCB2(10), PLCG1(9), PLCG2(25), PPAP2B(9), PPAP2C(8)	19344460	318	124	304	170	221	22	9	40	26	0	0.113	1.000	1.000
207	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(9), ABP1(20), ACADM(6), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3), AOC2(8), AOC3(8), CNDP1(9), DPYD(61), DPYS(24), ECHS1(2), EHHADH(7), GAD1(15), GAD2(10), HADHA(8), HIBCH(1), MLYCD(3), SMS(6), UPB1(6)	10482633	240	124	223	116	158	22	13	31	16	0	0.0952	1.000	1.000
208	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(3), C1GALT1(6), C1GALT1C1(2), GALNT1(4), GALNT10(6), GALNT11(3), GALNT12(9), GALNT13(29), GALNT14(27), GALNT2(6), GALNT3(3), GALNT4(6), GALNT5(9), GALNT6(17), GALNT7(5), GALNT8(24), GALNT9(5), GALNTL1(5), GALNTL2(23), GALNTL4(6), GALNTL5(14), GCNT1(7), GCNT3(7), GCNT4(4), OGT(10), ST3GAL1(6), ST3GAL2(1), ST6GALNAC1(5), WBSCR17(39)	12513867	291	124	272	144	217	15	8	24	27	0	0.170	1.000	1.000
209	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(6), ACAA2(2), ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH6(11), ADH7(13), ADHFE1(6), AKR1C4(9), AKR1D1(20), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH9A1(3), BAAT(12), CEL(13), CYP27A1(4), CYP7A1(9), HADHB(4), SOAT2(6), SRD5A1(3), SRD5A2(7)	9042360	255	123	228	104	172	26	15	24	18	0	0.000606	1.000	1.000
210	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(2), B4GALT2(2), FBP2(2), G6PC(7), GAA(7), GALE(1), GALK1(1), GALK2(3), GALT(2), GANAB(5), GCK(20), GLA(1), GLB1(8), HK1(3), HK2(12), HK3(15), LALBA(7), LCT(43), MGAM(142), PFKM(2), PGM1(4), PGM3(4)	12582356	295	123	275	158	216	29	7	26	17	0	0.0421	1.000	1.000
211	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(3), ACTR3(2), AKT1(3), ANGPTL2(3), DAG1(6), DGKA(4), ETFA(2), GCA(3), ITGA9(14), ITPKA(1), ITPKB(6), ITPR1(36), ITPR2(18), ITPR3(9), MAP2K1(13), MAPK1(4), MAPK3(1), NR1I3(7), PAK1(4), PDE3A(27), PDE3B(6), PI3(6), PIK3C2G(50), PIK3CA(9), PIK3CD(7), PIK3R1(7), RIPK3(11), VASP(3)	18783309	265	123	243	97	177	21	13	28	25	1	3.91e-05	1.000	1.000
212	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(3), AKT2(8), AKT3(4), ARHGEF11(19), BCL2(2), CDC42(3), DLG4(6), GNA13(1), LPA(53), MAP2K4(4), MAP3K1(3), MAP3K5(18), MAPK8(2), NFKB1(7), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PDK1(2), PHKA2(7), PI3(6), PIK3CB(26), PLD1(12), PLD2(7), PLD3(1), PTK2(8), RDX(1), ROCK1(5), ROCK2(13), SERPINA4(16), SRF(2), TBXA2R(4)	18989559	258	123	244	131	143	20	11	51	33	0	0.632	1.000	1.000
213	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(12), ATM(13), ATR(25), CCNA1(18), CCND1(1), CCNE1(4), CDC25A(8), CDK4(5), CDK6(3), CDKN1A(4), CDKN1B(1), CDKN2A(34), E2F1(7), GSK3B(2), HDAC1(1), RB1(8), SKP2(2), TFDP1(3), TGFB1(1), TGFB2(1), TGFB3(3), TP53(43)	11702750	199	122	169	48	97	8	14	25	53	2	1.51e-05	1.000	1.000
214	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(60), GABBR1(8), GPRC5A(4), GPRC5B(5), GPRC5C(8), GPRC5D(3), GRM1(17), GRM2(9), GRM3(54), GRM4(20), GRM5(15), GRM7(39), GRM8(50)	8096426	292	121	271	199	208	21	16	25	22	0	0.163	1.000	1.000
215	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(7), APOA1(2), CD36(4), CPT1B(10), CREBBP(23), EHHADH(7), EP300(14), FABP1(7), HSD17B4(6), JUN(1), LPL(3), MAPK1(4), MAPK3(1), ME1(20), MYC(5), NCOA1(10), NCOR1(20), NCOR2(26), NFKBIA(2), NR0B2(6), NR1H3(3), NR2F1(8), NRIP1(9), PDGFA(1), PIK3CA(9), PIK3R1(7), PPARA(7), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(11), PTGS2(11), RB1(8), RELA(5), RXRA(4), SP1(5), STAT5A(3), STAT5B(4), TNF(1)	24567258	297	121	288	140	189	20	19	37	29	3	0.277	1.000	1.000
216	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(5), AASDHPPT(3), AASS(4), ACAT2(1), AKR1B10(8), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3), BBOX1(5), DOT1L(11), ECHS1(2), EHHADH(7), EHMT1(8), EHMT2(9), GCDH(5), HADHA(8), HSD17B10(2), HSD17B4(6), HSD3B7(3), NSD1(17), OGDH(11), OGDHL(41), PIPOX(5), PLOD1(5), PLOD2(7), PLOD3(5), RDH11(2), RDH12(2), RDH13(3), SETD1A(24), SETD7(3), SETDB1(10), SHMT1(1), SHMT2(3), SUV39H1(1), SUV39H2(2), TMLHE(2)	22413042	268	119	259	126	175	27	14	35	17	0	0.0871	1.000	1.000
217	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(7), AADAC(16), ABAT(9), ACADS(4), ACAT2(1), ACSM1(27), AKR1B10(8), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH5A1(11), ALDH7A1(10), ALDH9A1(3), BDH1(5), DDHD1(7), ECHS1(2), EHHADH(7), GAD1(15), GAD2(10), HADHA(8), HMGCL(4), HMGCS1(2), HMGCS2(18), HSD17B10(2), HSD17B4(6), HSD3B7(3), ILVBL(4), L2HGDH(3), OXCT1(5), OXCT2(4), PDHA1(3), PDHA2(19), PDHB(1), PLA1A(9), PPME1(1), PRDX6(4), RDH11(2), RDH12(2), RDH13(3)	15757736	269	119	257	135	183	26	13	27	20	0	0.110	1.000	1.000
218	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(11), CFL1(1), GNAQ(5), GNAS(22), HRAS(4), LIMK1(4), MAP2K1(13), MAPK1(4), MAPK3(1), MYL2(5), NOX1(11), PIK3C2G(50), PLCB1(52), PPP1R12B(8), PRKCA(11), PTK2(8), RAF1(8), ROCK2(13)	9699960	232	118	208	91	164	9	7	33	19	0	0.0269	1.000	1.000
219	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(2), CHUK(2), DAXX(10), EGF(19), EGFR(23), ETS1(5), ETS2(9), FOS(2), HOXA7(2), HRAS(4), IKBKB(4), JUN(1), MAP2K1(13), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(4), MAP3K1(3), MAP3K14(4), MAP3K5(18), MAPK1(4), MAPK13(5), MAPK14(5), MAPK3(1), MAPK8(2), NFKB1(7), NFKBIA(2), PPP2CA(1), PRKCA(11), PRKCD(4), PRKCE(6), PRKCG(14), PRKCH(11), PRKCQ(18), RAF1(8), RELA(5), RIPK1(1), SP1(5), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF2(3)	18955484	261	118	248	156	164	24	12	37	24	0	0.863	1.000	1.000
220	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(5), BCR(11), BLNK(14), ELK1(2), FOS(2), GRB2(2), HRAS(4), JUN(1), LYN(7), MAP2K1(13), MAP3K1(3), MAPK1(4), MAPK3(1), MAPK8IP3(9), PAPPA(59), RAC1(17), RPS6KA1(9), RPS6KA3(2), SHC1(3), SOS1(9), SYK(16), VAV1(16), VAV2(4), VAV3(10)	12330944	223	118	195	115	163	15	5	22	17	1	0.286	1.000	1.000
221	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(3), AKT2(8), AKT3(4), ANKRD6(3), APC(22), AXIN1(11), AXIN2(4), CER1(13), CSNK1A1(3), CTNNB1(13), DACT1(11), DKK1(2), DKK2(17), DKK3(4), DKK4(3), FSTL1(2), GSK3B(2), LRP1(40), MVP(11), NKD1(8), NKD2(6), PIN1(1), PSEN1(1), PTPRA(7), SENP2(12), SFRP1(2), TSHB(7), WIF1(8)	15482607	228	117	221	115	131	26	13	33	25	0	0.434	1.000	1.000
222	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(21), ACACB(21), ACAT2(1), ACOT12(12), ACSS1(1), ACSS2(4), AKR1B1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(2), LDHA(6), LDHAL6A(5), LDHAL6B(7), LDHB(2), LDHC(5), LDHD(3), MDH1(1), MDH2(4), ME1(20), ME2(1), ME3(11), PC(13), PCK1(23), PCK2(4), PDHA1(3), PDHA2(19), PDHB(1), PKLR(11), PKM2(5)	18157333	252	116	242	130	163	21	15	35	18	0	0.182	1.000	1.000
223	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(10), ADRA1B(4), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(2), CHRM1(5), CHRM2(19), CHRM3(22), CHRM4(6), CHRM5(4), DRD1(11), DRD2(17), DRD3(6), DRD4(1), DRD5(23), HRH1(18), HRH2(4), HTR1A(8), HTR1B(1), HTR1D(3), HTR1E(6), HTR1F(8), HTR2A(9), HTR2B(2), HTR2C(12), HTR4(10), HTR5A(17), HTR6(1), HTR7(8)	9762946	251	116	231	186	159	35	8	25	24	0	0.0613	1.000	1.000
224	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(14), BTK(17), CALM1(1), CALM2(1), CD79A(2), CD79B(1), ELK1(2), FOS(2), GRB2(2), HRAS(4), JUN(1), LYN(7), MAP2K1(13), MAP3K1(3), MAPK14(5), MAPK3(1), MAPK8(2), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(11), RAC1(17), RAF1(8), SHC1(3), SOS1(9), SYK(16), SYT1(20), VAV1(16)	14803886	244	115	220	106	169	11	11	32	21	0	0.127	1.000	1.000
225	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(5), APAF1(6), ARHGDIB(3), BAG4(4), BCL2(2), BIRC2(5), BIRC3(8), CASP2(1), CASP3(2), CASP7(5), CASP8(9), CASP9(3), CFLAR(4), CHUK(2), CRADD(1), CYCS(1), DAXX(10), DFFA(2), DFFB(3), GSN(6), LMNA(9), LMNB1(2), LMNB2(4), MAP2K7(4), MAP3K1(3), MAP3K14(4), MAP3K5(18), MAPK8(2), MDM2(4), NFKB1(7), NFKBIA(2), NUMA1(8), PAK2(8), PRKCD(4), PRKDC(20), PSEN1(1), PSEN2(2), PTK2(8), RASA1(4), RB1(8), RELA(5), RIPK1(1), SPTAN1(8), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF1(6), TRAF2(3)	26807969	234	115	229	110	115	29	14	48	26	2	0.371	1.000	1.000
226	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(25), ATP4A(17), ATP4B(1), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(6), ATP5G2(1), ATP5H(1), ATP5J(2), ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A2(5), ATP6V0A4(20), ATP6V0D2(8), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C2(9), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), COX10(6), COX15(4), COX4I2(4), COX5B(1), COX6A1(1), COX6B1(1), COX6B2(1), COX6C(1), COX7B(1), COX7B2(2), COX8A(1), COX8C(1), CYC1(4), LHPP(1), NDUFA10(2), NDUFA12(1), NDUFA13(7), NDUFA4(1), NDUFA6(1), NDUFA9(2), NDUFAB1(1), NDUFB2(4), NDUFB3(1), NDUFB5(3), NDUFB6(2), NDUFC2(1), NDUFS2(2), NDUFS3(3), NDUFS4(3), NDUFS5(1), NDUFS6(2), NDUFS7(3), NDUFS8(3), NDUFV1(2), PPA1(1), PPA2(3), SDHA(3), SDHB(1), SDHC(3), SDHD(1), TCIRG1(3), UQCRC1(3), UQCRC2(3), UQCRFS1(2)	21730645	242	115	234	113	145	21	17	36	23	0	0.0873	1.000	1.000
227	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(6), ABO(5), B3GALNT1(6), B3GALT1(12), B3GALT2(1), B3GALT4(2), B3GALT5(1), B3GNT1(2), B3GNT2(2), B3GNT3(6), B3GNT4(4), B3GNT5(1), B4GALNT1(3), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT4(3), B4GALT6(1), FUT1(3), FUT2(3), FUT3(6), FUT4(2), FUT5(6), FUT6(4), FUT7(2), FUT9(25), GBGT1(2), PIGA(3), PIGB(4), PIGC(3), PIGF(2), PIGG(10), PIGH(1), PIGK(6), PIGL(2), PIGM(2), PIGN(4), PIGO(13), PIGQ(8), PIGS(1), PIGT(1), PIGU(7), PIGV(7), PIGX(2), PIGZ(3), ST3GAL1(6), ST3GAL2(1), ST3GAL3(2), ST3GAL4(1), ST3GAL5(2), ST3GAL6(2), ST6GALNAC3(6), ST6GALNAC4(1), ST6GALNAC5(7), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(9), UGCG(2)	18739389	236	115	231	131	139	24	13	34	26	0	0.320	1.000	1.000
228	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(6), BAX(3), BCL2(2), BIRC2(5), BIRC3(8), CASP2(1), CASP3(2), CASP7(5), CASP8(9), CASP9(3), CYCS(1), FAS(5), FASLG(14), GZMB(3), JUN(1), MAP2K4(4), MAP3K1(3), MAP3K14(4), MAPK10(9), MCL1(3), MDM2(4), MYC(5), NFKB1(7), NFKBIA(2), PARP1(10), PRF1(13), RELA(5), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TNFSF10(8), TP53(43), TRAF1(6), TRAF2(3)	14433242	205	114	195	76	114	21	15	23	32	0	0.0122	1.000	1.000
229	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), CDK5(4), CFL1(1), CHN1(6), LIMK1(4), MAP3K1(3), MYL2(5), MYLK(41), NCF2(7), PAK1(4), PDGFRA(32), PIK3CA(9), PIK3R1(7), PLD1(12), PPP1R12B(8), RAC1(17), RALBP1(2), RPS6KB1(2), TRIO(19), VAV1(16), WASF1(5)	13578447	205	114	188	112	135	12	12	25	20	1	0.658	1.000	1.000
230	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(7), EIF2B1(9), EIF2B2(2), EIF2B3(3), EIF2B4(1), EIF2B5(1), EIF2S1(1), ELAVL1(1), FLT1(33), FLT4(27), HIF1A(5), HRAS(4), KDR(45), NOS3(17), PIK3CA(9), PIK3R1(7), PLCG1(9), PRKCA(11), PTK2(8), PXN(3), SHC1(3), VHL(4)	13229941	210	114	194	105	133	16	5	26	29	1	0.374	1.000	1.000
231	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(12), ALOX12(5), ALOX15(9), ALOX5(9), CBR3(1), CYP4F2(12), CYP4F3(20), EPX(7), GGT1(7), LPO(18), LTA4H(4), MPO(11), PLA2G1B(1), PLA2G2A(2), PLA2G2E(4), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), PRDX1(2), PRDX2(2), PRDX6(4), PTGDS(2), PTGES2(2), PTGIS(12), PTGS1(17), PTGS2(11), TBXAS1(14), TPO(45)	10796515	276	113	266	166	211	22	3	21	19	0	0.118	1.000	1.000
232	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(49), C5(16), C6(66), C7(52), C8A(40), C9(22)	4823438	245	112	213	89	192	8	4	20	20	1	0.000805	1.000	1.000
233	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(6), AARS2(3), ABAT(9), ACY3(3), ADSL(7), ADSS(2), ADSSL1(8), AGXT(10), AGXT2(20), ASL(6), ASNS(9), ASPA(3), ASRGL1(3), ASS1(8), CAD(18), CRAT(6), DARS(4), DARS2(3), DDO(7), DLAT(2), DLD(2), GAD1(15), GAD2(10), GOT1(6), GOT2(7), GPT(3), GPT2(1), NARS(2), NARS2(5), PC(13), PDHA1(3), PDHA2(19), PDHB(1)	14699909	224	112	212	105	160	20	10	24	10	0	0.0276	1.000	1.000
234	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(9), ACAA1(6), ACAA2(2), ACADM(6), ACADS(4), ACAT2(1), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH6A1(5), ALDH7A1(10), ALDH9A1(3), AOX1(24), AUH(3), BCAT1(11), BCAT2(2), BCKDHA(2), BCKDHB(2), DBT(1), DLD(2), ECHS1(2), EHHADH(7), HADHA(8), HADHB(4), HIBADH(8), HIBCH(1), HMGCL(4), HMGCS1(2), HMGCS2(18), HSD17B10(2), HSD17B4(6), IVD(4), MCCC1(5), MCCC2(3), MCEE(2), MUT(7), OXCT1(5), OXCT2(4), PCCA(5), PCCB(3)	16743933	217	112	207	100	136	20	13	33	15	0	0.241	1.000	1.000
235	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(20), ACY3(3), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH7A1(10), ALDH9A1(3), AMDHD1(5), AOC2(8), AOC3(8), ASPA(3), CARM1(6), CNDP1(9), DDC(12), FTCD(3), HAL(12), HARS(6), HARS2(4), HDC(22), HEMK1(5), HNMT(1), LCMT1(4), MAOA(4), MAOB(13), METTL2B(8), METTL6(3), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), PRPS1(2), PRPS2(4), UROC1(13), WBSCR22(1)	15309621	249	112	242	152	165	26	14	24	20	0	0.461	1.000	1.000
236	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(4), ADRBK2(4), ARRB2(6), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CLCA1(7), CLCA2(10), CLCA4(30), CNGA3(26), CNGA4(14), CNGB1(21), GNAL(2), GUCA1A(5), GUCA1B(2), GUCA1C(7), PDC(6), PDE1C(44), PRKACA(4), PRKACB(4), PRKACG(8), PRKG1(13), PRKG2(16), PRKX(4)	11693170	267	112	254	148	185	22	7	32	21	0	0.229	1.000	1.000
237	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(29), AR(7), ESR1(5), ESR2(8), ESRRA(3), HNF4A(19), NPM1(3), NR0B1(2), NR1D2(10), NR1H2(3), NR1H3(3), NR1I2(3), NR1I3(7), NR2C2(2), NR2E1(4), NR2F1(8), NR2F2(2), NR2F6(1), NR3C1(7), NR4A1(4), NR4A2(4), NR5A1(7), NR5A2(19), PGR(15), PPARA(7), PPARD(3), PPARG(11), RARA(3), RARB(5), RARG(2), ROR1(13), RORA(4), RORC(8), RXRA(4), RXRB(4), RXRG(5), THRA(4), THRB(17), VDR(3)	16136915	268	112	258	134	194	22	5	26	21	0	0.0523	1.000	1.000
238	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(20), AGXT(10), AGXT2(20), ALAS1(1), ALAS2(5), AMT(2), AOC2(8), AOC3(8), BHMT(9), CBS(7), CHDH(7), CHKA(2), CHKB(3), CPT1B(10), CTH(1), DAO(10), DLD(2), DMGDH(12), GAMT(4), GARS(6), GATM(5), GCAT(5), GLDC(5), MAOA(4), MAOB(13), PEMT(2), PISD(2), PLCB2(10), PLCG1(9), PLCG2(25), PSPH(2), SARDH(20), SARS(10), SHMT1(1), SHMT2(3), TARS(2)	16300374	265	111	254	149	182	20	16	26	21	0	0.188	1.000	1.000
239	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(6), ARG1(2), ARG2(1), ASL(6), ASS1(8), CKM(2), CKMT1A(1), CKMT2(5), CPS1(22), DAO(10), EPRS(11), GAMT(4), GATM(5), GLUD1(2), GLUD2(4), GOT1(6), GOT2(7), LAP3(1), NOS1(65), NOS3(17), OAT(3), OTC(3), P4HA1(9), P4HA2(5), P4HA3(13), PRODH(1), PYCR1(2), PYCR2(2), RARS(7), RARS2(2)	13875997	232	111	220	128	161	24	9	17	21	0	0.271	1.000	1.000
240	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(29), AKT1(3), GNAI1(1), ITGAV(9), ITGB3(12), MAPK1(4), MAPK3(1), PDGFA(1), PDGFRA(32), PIK3CA(9), PIK3R1(7), PLCB1(52), PRKCA(11), PTK2(8), RAC1(17), SMPD1(3), SMPD2(2), SPHK1(1), SRC(1)	10673477	203	110	185	87	143	9	9	23	18	1	0.0234	1.000	1.000
241	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(23), ELK1(2), GNAS(22), GRB2(2), HRAS(4), IGF1R(11), ITGB1(4), KLK2(2), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK3(1), MKNK1(5), MKNK2(2), MYC(5), NGFR(8), PDGFRA(32), PPP2CA(1), PTPRR(26), RAF1(8), RPS6KA1(9), RPS6KA5(4), SHC1(3), SOS1(9), SRC(1), STAT3(11)	12738504	217	110	204	101	142	19	13	30	13	0	0.153	1.000	1.000
242	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(9), ALPL(9), ALPP(11), ALPPL2(12), ASCC3(11), ATP13A2(10), DDX18(4), DDX19A(1), DDX23(5), DDX4(11), DDX41(6), DDX47(1), DDX50(5), DDX51(5), DDX52(4), DDX54(2), DDX55(3), DDX56(3), DHX58(4), ENTPD7(2), EP400(25), ERCC2(2), ERCC3(5), FPGS(3), GGH(2), IFIH1(13), MOV10L1(28), NUDT5(2), NUDT8(1), QDPR(3), RAD54B(6), RUVBL2(4), SETX(17), SKIV2L2(4), SMARCA2(11), SMARCA5(5), SPR(2)	24184123	251	110	239	138	162	17	12	32	28	0	0.650	1.000	1.000
243	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(6), AGTR1(11), ATF2(5), CALM1(1), CALM2(1), EGFR(23), ELK1(2), GNAQ(5), GRB2(2), HRAS(4), JUN(1), MAP2K1(13), MAP2K2(4), MAP2K4(4), MAP3K1(3), MAPK1(4), MAPK3(1), MAPK8(2), MEF2A(5), MEF2B(3), MEF2C(3), MEF2D(5), PAK1(4), PRKCA(11), PTK2(8), PTK2B(11), RAC1(17), RAF1(8), SHC1(3), SOS1(9), SRC(1), SYT1(20)	12947376	200	109	174	99	133	14	9	26	18	0	0.475	1.000	1.000
244	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(20), AGXT(10), AGXT2(20), AKR1B10(8), ALAS1(1), ALAS2(5), AMT(2), AOC2(8), AOC3(8), BHMT(9), CBS(7), CHDH(7), CHKA(2), CHKB(3), CTH(1), DAO(10), DLD(2), DMGDH(12), GAMT(4), GARS(6), GATM(5), GCAT(5), GLDC(5), GNMT(1), HSD3B7(3), MAOA(4), MAOB(13), PEMT(2), PHGDH(13), PIPOX(5), PISD(2), PSAT1(2), PSPH(2), RDH11(2), RDH12(2), RDH13(3), SARDH(20), SARS(10), SARS2(3), SDS(2), SHMT1(1), SHMT2(3), TARS(2), TARS2(7)	16567507	262	109	247	149	174	19	14	28	27	0	0.326	1.000	1.000
245	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(5), CHUK(2), ELK1(2), FOS(2), IKBKB(4), IRAK1(5), JUN(1), LY96(4), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP3K1(3), MAP3K14(4), MAP3K7(1), MAPK14(5), MAPK8(2), MYD88(3), NFKB1(7), NFKBIA(2), PPARA(7), RELA(5), TIRAP(1), TLR10(12), TLR2(17), TLR3(10), TLR4(34), TLR6(6), TLR7(16), TLR9(14), TOLLIP(1), TRAF6(5)	14048251	196	109	193	101	123	22	11	25	15	0	0.351	1.000	1.000
246	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(5), ACTN1(5), ACTN2(24), ACTN3(7), BCAR1(5), BCR(11), CAPN1(4), CAPNS1(1), CAV1(2), CRKL(2), CSK(1), FYN(7), GRB2(2), HRAS(4), ITGA1(18), ITGB1(4), JUN(1), MAP2K1(13), MAP2K2(4), MAPK1(4), MAPK3(1), MAPK8(2), PPP1R12B(8), PTK2(8), PXN(3), RAF1(8), RAP1A(2), ROCK1(5), SHC1(3), SOS1(9), SRC(1), TLN1(14), VCL(7), ZYX(7)	18081538	202	108	189	98	117	20	10	31	23	1	0.187	1.000	1.000
247	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(21), ACAT2(1), ADH5(3), AKR1B1(2), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH9A1(3), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(2), LDHA(6), LDHB(2), LDHC(5), LDHD(3), MDH1(1), MDH2(4), ME1(20), ME2(1), ME3(11), PC(13), PCK1(23), PDHA1(3), PDHA2(19), PDHB(1), PKLR(11), PKM2(5)	14353749	208	108	201	110	141	18	10	25	14	0	0.333	1.000	1.000
248	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(5), BLVRA(3), BLVRB(1), CP(12), CPOX(4), EPRS(11), FECH(3), GUSB(4), HCCS(2), HMBS(2), HMOX1(1), HMOX2(2), PPOX(3), UGT1A1(5), UGT1A10(15), UGT1A3(12), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(12), UGT1A8(7), UGT1A9(11), UGT2B15(29), UGT2B4(36), UROS(1)	10710479	205	107	192	95	138	19	13	13	21	1	0.0778	1.000	1.000
249	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(9), F2R(7), F2RL3(3), GNAI1(1), HRAS(4), ITGA1(18), ITGB1(4), MAP2K1(13), MAPK1(4), MAPK3(1), PLA2G4A(11), PLCB1(52), PRKCA(11), PTGS1(17), PTK2(8), RAF1(8), SRC(1), SYK(16), TBXAS1(14)	9428830	202	107	182	93	143	13	6	21	19	0	0.104	1.000	1.000
250	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(11), EGF(19), EGFR(23), GRB2(2), HRAS(4), MAP2K1(13), MAPK1(4), MAPK3(1), PTPRB(91), RAF1(8), RASA1(4), SHC1(3), SOS1(9), SPRY1(7), SPRY2(4), SPRY3(12), SPRY4(2), SRC(1)	9677005	218	107	197	92	152	16	9	25	16	0	0.151	1.000	1.000
251	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(17), DLG4(6), EPHB2(31), F2(9), F2RL1(16), F2RL2(6), F2RL3(3), JUN(1), MAP2K5(3), MAPK1(4), MAPK7(4), MAPK8(2), MYEF2(4), PLD1(12), PLD2(7), PLD3(1), PTK2(8), RAF1(8), RASAL1(15), SRC(1), TEC(10), VAV1(16)	10602856	184	107	176	114	105	18	7	37	17	0	0.876	1.000	1.000
252	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(6), ACAA2(2), ACADL(4), ACADM(6), ACADS(4), ACADSB(6), ACAT2(1), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH6A1(5), ALDH9A1(3), AOX1(24), BCAT1(11), BCKDHA(2), BCKDHB(2), ECHS1(2), EHHADH(7), HADHA(8), HADHB(4), HIBADH(8), HMGCL(4), IVD(4), MCCC1(5), MCCC2(3), MCEE(2), MUT(7), OXCT1(5), PCCA(5), PCCB(3), SDS(2)	14019237	186	107	178	88	120	16	9	25	16	0	0.297	1.000	1.000
253	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), DAG1(6), ITPKA(1), ITPKB(6), ITPR1(36), ITPR2(18), ITPR3(9), NFAT5(8), PDE6A(14), PDE6B(15), PDE6C(27), PDE6D(2), PDE6G(2), SLC6A13(27), TF(13)	13810178	206	106	193	115	144	14	7	20	21	0	0.125	1.000	1.000
254	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(13), ATR(25), BRCA1(9), CDC25A(8), CDC25B(6), CDC25C(5), CDC34(4), CDKN1A(4), CHEK1(2), CHEK2(2), EP300(14), MDM2(4), MYT1(22), PRKDC(20), RPS6KA1(9), TP53(43), WEE1(3), YWHAQ(3)	16304831	196	105	184	70	104	16	13	30	33	0	0.112	1.000	1.000
255	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(21), CALCR(17), CALCRL(15), CD97(6), CRHR1(7), CRHR2(4), ELTD1(25), EMR1(27), EMR2(5), GHRHR(4), GIPR(2), GLP1R(11), GLP2R(14), GPR64(6), LPHN1(9), LPHN2(38), LPHN3(21), SCTR(10), VIPR1(4), VIPR2(5)	10205512	251	105	234	157	176	19	14	20	22	0	0.266	1.000	1.000
256	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(3), ARSE(5), B4GALT6(1), CERK(1), DEGS1(1), DEGS2(4), ENPP7(6), GAL3ST1(9), GALC(4), GBA(5), GLA(1), GLB1(8), LCT(43), NEU1(7), NEU2(14), NEU3(3), NEU4(9), PPAP2B(9), PPAP2C(8), SGMS1(15), SGMS2(1), SGPP2(7), SMPD1(3), SMPD2(2), SMPD3(9), SMPD4(7), SPHK1(1), SPHK2(7), SPTLC1(1), SPTLC2(6), UGCG(2), UGT8(7)	13722229	209	105	199	133	147	15	5	26	16	0	0.767	1.000	1.000
257	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(6), AARS2(3), CARS(10), CARS2(2), DARS(4), DARS2(3), EPRS(11), FARS2(5), FARSA(6), FARSB(5), GARS(6), HARS(6), HARS2(4), IARS(8), IARS2(14), KARS(6), LARS(10), LARS2(5), MARS(6), MARS2(4), MTFMT(2), NARS(2), NARS2(5), QARS(6), RARS(7), RARS2(2), SARS(10), SARS2(3), TARS(2), TARS2(7), VARS(18), VARS2(6), WARS(4), WARS2(4), YARS(1), YARS2(2)	21221033	205	105	190	109	127	21	10	26	21	0	0.590	1.000	1.000
258	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(3), ACTR3(2), ARHGAP1(2), ARHGAP4(3), ARHGAP5(12), ARHGAP6(11), ARHGEF1(1), ARHGEF11(19), ARHGEF5(17), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), BAIAP2(7), CFL1(1), DIAPH1(6), GSN(6), LIMK1(4), MYL2(5), MYLK(41), OPHN1(4), PIP5K1A(6), PIP5K1B(20), PPP1R12B(8), ROCK1(5), SRC(1), TLN1(14), VCL(7)	17440939	212	105	203	108	150	14	7	26	15	0	0.141	1.000	1.000
259	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(3), GHR(30), GRB2(2), HRAS(4), INSR(22), IRS1(6), JAK2(9), MAP2K1(13), MAPK1(4), MAPK3(1), PIK3CA(9), PIK3R1(7), PLCG1(9), PRKCA(11), PTPN6(3), RAF1(8), RPS6KA1(9), SHC1(3), SLC2A4(8), SOS1(9), SRF(2), STAT5A(3), STAT5B(4)	12856459	179	104	165	89	105	14	10	30	19	1	0.441	1.000	1.000
260	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(29), CALM1(1), CALM2(1), ELK1(2), FOS(2), GNAI1(1), GNAQ(5), GNAS(22), HRAS(4), JUN(1), MAP2K1(13), MAPK3(1), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(11), RAF1(8), RPS6KA3(2), SYT1(20)	13455083	212	104	196	122	143	15	10	24	20	0	0.800	1.000	1.000
261	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(5), CRK(3), CXCL12(2), CXCR4(4), GNAI1(1), GNAQ(5), HRAS(4), MAP2K1(13), MAPK1(4), MAPK3(1), NFKB1(7), PIK3C2G(50), PIK3CA(9), PIK3R1(7), PLCG1(9), PRKCA(11), PTK2(8), PTK2B(11), PXN(3), RAF1(8), RELA(5)	10642526	170	103	153	80	110	11	5	26	17	1	0.265	1.000	1.000
262	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(3), APC(22), AXIN1(11), CCND1(1), CD14(5), CTNNB1(13), FZD1(4), GJA1(8), GNAI1(1), GSK3B(2), IRAK1(5), LBP(9), LEF1(3), LY96(4), MYD88(3), NFKB1(7), PDPK1(4), PIK3CA(9), PIK3R1(7), PPP2CA(1), RELA(5), TIRAP(1), TLR4(34), TOLLIP(1), WNT1(2)	11777732	165	103	160	79	97	13	12	21	21	1	0.443	1.000	1.000
263	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(20), ALDH1A3(2), ALDH3A1(7), ALDH3B1(2), ALDH3B2(7), AOC2(8), AOC3(8), DDC(12), EPX(7), ESCO1(2), ESCO2(3), GOT1(6), GOT2(7), HPD(5), LPO(18), MAOA(4), MAOB(13), MPO(11), MYST3(16), MYST4(16), NAT6(2), PNPLA3(2), PRDX6(4), SH3GLB1(2), TAT(17), TPO(45)	13279656	246	103	239	154	181	21	12	18	14	0	0.679	1.000	1.000
264	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10(4), ALG10B(4), ALG12(1), ALG13(9), ALG14(2), ALG2(4), ALG3(4), ALG5(2), ALG6(3), ALG8(6), ALG9(5), B4GALT1(2), B4GALT2(2), B4GALT3(3), DAD1(1), DDOST(3), DHDDS(1), DOLPP1(4), DPAGT1(2), DPM1(1), FUT8(8), GANAB(5), MAN1A1(17), MAN1A2(6), MAN1B1(4), MAN1C1(8), MAN2A1(10), MGAT1(3), MGAT2(3), MGAT3(10), MGAT4A(8), MGAT4B(1), MGAT5(5), MGAT5B(10), RFT1(3), RPN2(2), ST6GAL1(5), STT3B(7)	16408317	180	102	175	98	107	19	12	19	23	0	0.417	1.000	1.000
265	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(9), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3), CYP2C19(42), CYP2C9(38), DHRS1(3), DHRS2(7), DHRS3(4), DHRS7(1), DHRSX(4), ECHS1(2), EHHADH(7), ESCO1(2), ESCO2(3), HADHA(8), MYST3(16), MYST4(16), NAT6(2), PNPLA3(2), SH3GLB1(2), YOD1(1)	12028011	206	102	193	130	133	20	11	27	15	0	0.931	1.000	1.000
266	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(4), APC(22), ATF2(5), AXIN1(11), BMP10(15), BMP2(6), BMP4(3), BMP5(27), BMP7(2), BMPR1A(2), BMPR2(6), CHRD(14), CTNNB1(13), FZD1(4), GATA4(3), GSK3B(2), MAP3K7(1), MEF2C(3), MYL2(5), NKX2-5(2), NOG(1), NPPA(3), NPPB(5), RFC1(7), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(7), TGFBR3(6), WNT1(2)	14011168	186	101	175	88	123	16	7	19	21	0	0.432	1.000	1.000
267	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(12), DIAPH1(6), FYN(7), GSN(6), HRAS(4), ITGA1(18), ITGB1(4), MAP2K1(13), MAPK1(4), MAPK3(1), MYL2(5), MYLK(41), PIK3CA(9), PIK3R1(7), PTK2(8), PXN(3), RAF1(8), ROCK1(5), SHC1(3), SRC(1), TLN1(14)	14459907	179	101	161	88	116	12	7	26	17	1	0.386	1.000	1.000
268	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(3), EIF4A1(3), EIF4A2(4), EIF4E(1), EIF4EBP1(1), EIF4G1(14), EIF4G2(5), EIF4G3(17), GHR(30), IRS1(6), MAPK1(4), MAPK14(5), MAPK3(1), MKNK1(5), PABPC1(5), PDK2(4), PDPK1(4), PIK3CA(9), PIK3R1(7), PRKCA(11), PTEN(23), RPS6KB1(2)	10967969	164	101	154	55	84	15	12	16	36	1	0.0515	1.000	1.000
269	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(5), CALM1(1), CALM2(1), CRKL(2), GNAQ(5), GRB2(2), HRAS(4), JUN(1), MAP2K1(13), MAP2K2(4), MAP2K3(9), MAP2K4(4), MAP3K1(3), MAPK1(4), MAPK14(5), MAPK3(1), MAPK8(2), PAK1(4), PLCG1(9), PRKCA(11), PTK2B(11), RAC1(17), RAF1(8), SHC1(3), SOS1(9), SRC(1), SYT1(20)	11022390	159	101	136	78	102	13	7	24	13	0	0.409	1.000	1.000
270	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(5), AKT1(3), AKT2(8), AKT3(4), DAG1(6), GNAQ(5), ITPKA(1), ITPKB(6), ITPR1(36), ITPR2(18), ITPR3(9), NFKB1(7), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PDK1(2), PHKA2(7), PIK3CB(26), PITX2(4), PLD1(12), PLD2(7), PLD3(1)	17347085	182	101	171	107	86	19	15	41	21	0	0.700	1.000	1.000
271	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(6), BAX(3), BCL2(2), BCL2A1(1), BCL2L2(2), CASP1(5), CASP10(5), CASP2(1), CASP3(2), CASP4(1), CASP7(5), CASP8(9), CASP9(3), CD40(4), CD40LG(2), CRADD(1), CYCS(1), DAXX(10), DFFA(2), DFFB(3), FAS(5), FASLG(14), IKBKE(12), LTA(2), MCL1(3), NFKB1(7), NFKBIA(2), NGFR(8), NR3C1(7), NTRK1(19), PTPN13(13), RIPK1(1), SFRS2IP(7), TFG(2), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF1(6), TRAF2(3), TRAF3(5), TRAF6(5)	16788612	196	100	193	106	126	17	9	23	21	0	0.702	1.000	1.000
272	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(3), AKT2(8), AKT3(4), CISH(3), GRB2(2), IARS(8), IL13RA1(3), IL2RG(3), IL4(1), IL4R(14), INPP5D(37), JAK1(6), JAK2(9), JAK3(7), NR0B2(6), PI3(6), PIK3CA(9), PPP1R13B(8), RPS6KB1(2), SERPINA4(16), SHC1(3), SOS1(9), SOS2(13), SRC(1), STAT6(8), TYK2(8)	14269179	197	100	190	88	129	14	10	26	18	0	0.183	1.000	1.000
273	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(13), ATR(25), BRCA1(9), BRCA2(21), CHEK1(2), CHEK2(2), FANCA(7), FANCC(3), FANCD2(13), FANCE(2), FANCF(1), FANCG(4), HUS1(1), MRE11A(6), RAD1(2), RAD17(5), RAD50(5), RAD51(1), RAD9A(6), TP53(43)	17121482	171	99	160	65	100	5	11	23	32	0	0.270	1.000	1.000
274	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ACAD9(1), ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(6), DHRS1(3), DHRS2(7), DHRS3(4), DHRS7(1), DHRSX(4), ESCO1(2), ESCO2(3), MYST3(16), MYST4(16), NAT6(2), PNPLA3(2), SH3GLB1(2)	9724311	183	99	161	84	130	15	8	23	7	0	0.281	1.000	1.000
275	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(4), ANXA2(2), ANXA3(4), ANXA4(2), ANXA5(1), ANXA6(6), CYP11A1(15), EDN1(9), EDNRA(9), EDNRB(5), HPGD(1), HSD11B1(11), HSD11B2(2), PLA2G4A(11), PRL(1), PTGDR(9), PTGDS(2), PTGER2(6), PTGER4(1), PTGFR(22), PTGIR(6), PTGIS(12), PTGS1(17), PTGS2(11), S100A6(1), SCGB1A1(1), TBXAS1(14)	7930785	185	99	176	79	130	18	3	16	18	0	0.00154	1.000	1.000
276	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(3), BCL2(2), EGFR(23), IGF1R(11), MYC(5), POLR2A(12), PPP2CA(1), PRKCA(11), RB1(8), TEP1(31), TERF1(2), TERT(9), TNKS(7), TP53(43), XRCC5(2)	10904582	170	99	159	79	98	13	13	18	26	2	0.140	1.000	1.000
277	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(3), CABIN1(11), CALM1(1), CALM2(1), CAMK1(5), CAMK1G(11), HDAC5(7), IGF1(11), IGF1R(11), INSR(22), MAP2K6(3), MAPK14(5), MAPK7(4), MEF2A(5), MEF2B(3), MEF2C(3), MEF2D(5), MYOD1(1), NFATC1(15), NFATC2(9), PIK3CA(9), PIK3R1(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYT1(20)	13500616	183	98	175	98	119	15	6	26	16	1	0.404	1.000	1.000
278	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(3), ACP2(2), ACP5(3), ACP6(11), ACPP(8), ACPT(1), ALPI(9), ALPL(9), ALPP(11), ALPPL2(12), CMBL(4), CYP3A4(20), CYP3A43(16), CYP3A5(10), CYP3A7(21), DHRS1(3), DHRS2(7), DHRS3(4), DHRS7(1), DHRSX(4), PON1(15), PON2(1), PON3(6)	6959171	181	98	170	63	131	13	8	12	17	0	2.70e-05	1.000	1.000
279	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(9), ACACA(21), ACACB(21), ACADM(6), ACAT2(1), ACSS1(1), ACSS2(4), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH6A1(5), ALDH7A1(10), ALDH9A1(3), ECHS1(2), EHHADH(7), HADHA(8), HIBCH(1), LDHA(6), LDHAL6A(5), LDHAL6B(7), LDHB(2), LDHC(5), MCEE(2), MLYCD(3), MUT(7), PCCA(5), PCCB(3), SUCLG1(2), SUCLG2(2)	15445376	172	97	165	87	103	16	14	28	11	0	0.395	1.000	1.000
280	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(5), ACTG2(5), ADCY3(4), ADCY9(9), AK1(1), ARF4(3), ARF5(1), ARL4D(3), ATP6V0A1(9), ATP6V0A2(5), ATP6V0A4(20), ATP6V0D2(8), ATP6V0E1(1), ATP6V1A(3), ATP6V1C2(9), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), ERO1L(5), GNAS(22), PDIA4(4), PLCG1(9), PLCG2(25), PRKCA(11), SEC61A1(2), SEC61A2(8), TRIM23(2)	14377298	191	97	185	124	129	9	9	26	18	0	0.749	1.000	1.000
281	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(4), UCHL1(5), UCHL3(2), UGDH(1), UGT1A1(5), UGT1A10(15), UGT1A3(12), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(12), UGT1A8(7), UGT1A9(11), UGT2B15(29), UGT2B4(36)	6866448	165	97	149	82	114	16	11	8	15	1	0.0990	1.000	1.000
282	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(5), CR1(54), CR2(33), FCGR2B(3), HLA-DRA(11), HLA-DRB1(4), ICAM1(3), ITGAL(24), ITGB2(14), PTPRC(33)	5824251	184	96	176	70	125	15	5	15	24	0	0.0206	1.000	1.000
283	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(16), ADH1B(31), ADH1C(28), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(6), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3)	5130789	156	96	133	59	112	15	9	14	6	0	0.00176	1.000	1.000
284	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(6), HLA-A(3), IL18(2), ITGB1(4), KLRC1(5), KLRC2(1), KLRC3(11), KLRC4(5), KLRD1(5), LAT(1), MAP2K1(13), MAPK3(1), PAK1(4), PIK3CA(9), PIK3R1(7), PTK2B(11), PTPN6(3), RAC1(17), SYK(16), VAV1(16)	7190747	140	96	118	67	99	5	3	16	16	1	0.307	1.000	1.000
285	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(5), CDC42(3), DAXX(10), DDIT3(2), ELK1(2), GRB2(2), HMGN1(2), HRAS(4), HSPB1(2), HSPB2(1), MAP2K4(4), MAP2K6(3), MAP3K1(3), MAP3K5(18), MAP3K7(1), MAP3K9(24), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MEF2A(5), MEF2B(3), MEF2C(3), MEF2D(5), MKNK1(5), MYC(5), PLA2G4A(11), RAC1(17), RIPK1(1), RPS6KA5(4), SHC1(3), STAT1(4), TGFB1(1), TGFB2(1), TGFB3(3), TRAF2(3)	14078952	171	96	158	63	111	14	4	23	19	0	0.0509	1.000	1.000
286	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(4), JAK1(6), JUN(1), MAP2K1(13), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(2), PDGFA(1), PDGFRA(32), PIK3CA(9), PIK3R1(7), PLCG1(9), PRKCA(11), RAF1(8), RASA1(4), SHC1(3), SOS1(9), SRF(2), STAT1(4), STAT3(11), STAT5A(3)	13510805	154	96	144	64	84	16	9	27	17	1	0.251	1.000	1.000
287	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(20), ALDH1A3(2), ALDH3A1(7), ALDH3B1(2), ALDH3B2(7), AOC2(8), AOC3(8), DDC(12), EPX(7), GOT1(6), GOT2(7), HPD(5), LPO(18), MAOA(4), MAOB(13), MPO(11), PRDX1(2), PRDX2(2), PRDX6(4), TAT(17), TPO(45)	8489581	207	96	201	125	159	17	9	10	12	0	0.115	1.000	1.000
288	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(9), CARM1(6), CCND1(1), CREBBP(23), EP300(14), ERCC3(5), ESR1(5), GRIP1(10), GTF2A1(2), GTF2E1(2), GTF2F1(5), HDAC1(1), HDAC2(1), HDAC3(6), HDAC4(10), HDAC5(7), HDAC6(2), MEF2C(3), NCOR2(26), NR0B1(2), NRIP1(9), PELP1(12), POLR2A(12), TBP(4)	17607210	177	95	176	87	120	6	11	26	14	0	0.484	1.000	1.000
289	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(29), AKT1(3), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), GNAS(22), GRB2(2), HRAS(4), MAPK1(4), MAPK14(5), MAPK3(1), PIK3CA(9), PIK3R1(7), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(11), RAC1(17), RPS6KA1(9), RPS6KA5(4), SOS1(9)	11205701	181	95	166	101	123	13	8	17	19	1	0.695	1.000	1.000
290	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(18), CD2(23), CD33(18), CD5(7), CSF2(2), IFNA1(1), IFNB1(6), IFNG(2), IL10(3), IL12A(3), IL12B(4), IL13(2), IL3(3), IL4(1), IL5(4), ITGAX(20), TLR2(17), TLR4(34), TLR7(16), TLR9(14)	7191921	198	95	190	104	137	17	10	15	19	0	0.00446	1.000	1.000
291	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(20), ACY1(2), ADC(5), AGMAT(3), ALDH18A1(7), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3), AOC2(8), AOC3(8), ARG1(2), ARG2(1), ASL(6), ASS1(8), CPS1(22), GATM(5), MAOA(4), MAOB(13), NAGS(1), ODC1(3), OTC(3), SAT2(1), SMS(6)	11310425	165	95	160	99	99	18	13	17	18	0	0.562	1.000	1.000
292	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(6), ICAM1(3), ITGA4(38), ITGAL(24), ITGAM(21), ITGB1(4), ITGB2(14), SELE(36), SELL(8), SELP(31)	6115804	185	95	176	59	139	4	6	14	22	0	0.000248	1.000	1.000
293	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(9), EEF1B2(1), EEF1D(1), EEF1G(1), EEF2(2), EEF2K(7), EIF1AX(3), EIF2AK1(4), EIF2AK2(6), EIF2AK3(19), EIF2B1(9), EIF2B2(2), EIF2B3(3), EIF2B4(1), EIF2B5(1), EIF2S1(1), EIF4A1(3), EIF4A2(4), EIF4E(1), EIF4EBP1(1), EIF4G1(14), EIF4G3(17), EIF5(2), EIF5B(2), ETF1(2), GSPT2(8), KIAA0664(4), PABPC1(5), PABPC3(10), PAIP1(7), SLC35A4(4)	16919858	154	95	145	82	77	13	11	22	31	0	0.906	1.000	1.000
294	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(6), AZIN1(1), BTG1(2), CBX3(1), CLOCK(5), CRY1(7), CRY2(3), DAZAP2(1), DNAJA1(1), EIF4G2(5), ETV6(13), GFRA1(8), GSTM3(4), GSTP1(2), HERPUD1(3), HSPA8(5), IDI1(1), KLF9(2), MYF6(12), NCKAP1(7), NCOA4(5), NR1D2(10), PER1(8), PER2(13), PIGF(2), PPP1R3C(3), PPP2CB(2), PSMA4(2), PURA(3), SF3A3(4), TOB1(3), TUBB3(5), UCP3(4), UGP2(2), VAPA(1), ZFR(9)	14149570	165	94	162	73	79	15	14	32	25	0	0.601	1.000	1.000
295	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(10), F2(9), F2R(7), F3(2), F5(37), F7(9), FGA(42), FGB(10), FGG(8), PROC(9), PROS1(13), SERPINC1(8), TFPI(10)	6366933	174	94	159	71	116	21	10	17	10	0	0.0948	1.000	1.000
296	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(28), F2(9), F2R(7), FGA(42), FGB(10), FGG(8), PLAT(4), PLAU(3), PLG(33), SERPINB2(19), SERPINE1(5)	5178375	169	94	157	68	125	13	8	14	9	0	0.0645	1.000	1.000
297	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(20), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH9A1(3), AOC2(8), AOC3(8), ASPA(3), CNDP1(9), DDC(12), HAL(12), HARS(6), HDC(22), HNMT(1), MAOA(4), MAOB(13), PRPS1(2), PRPS2(4)	9423316	177	94	172	112	119	17	10	14	17	0	0.532	1.000	1.000
298	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(2), EXT2(6), EXTL1(2), EXTL3(11), GLCE(9), HS2ST1(1), HS3ST1(11), HS3ST2(8), HS3ST3A1(4), HS3ST3B1(2), HS3ST5(8), HS6ST1(3), HS6ST2(3), HS6ST3(16), NDST1(4), NDST2(2), NDST3(25), NDST4(50)	7885528	167	94	160	87	109	13	6	20	19	0	0.179	1.000	1.000
299	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(17), ANAPC10(1), ANAPC2(5), ANAPC4(4), ANAPC5(7), ANAPC7(6), BTRC(5), CDC16(2), CDC20(1), CDC23(3), CDC27(10), CUL1(7), CUL2(4), CUL3(6), FBXW11(5), FBXW7(12), FZR1(7), ITCH(8), SKP2(2), SMURF1(1), SMURF2(9), TCEB1(1), TCEB2(1), UBA1(3), UBE2D1(1), UBE2D3(3), UBE2E1(1), UBE2E2(4), UBE2E3(1), VHL(4), WWP1(3), WWP2(7)	15467801	151	94	143	63	90	5	13	24	18	1	0.469	1.000	1.000
300	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(5), CAPN1(4), CAPN2(6), CAPNS1(1), CXCR3(5), EGF(19), EGFR(23), HRAS(4), ITGA1(18), ITGB1(4), MAPK1(4), MAPK3(1), MYL2(5), MYLK(41), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PTK2(8), PXN(3), TLN1(14)	12574382	188	94	181	115	132	11	10	19	16	0	0.639	1.000	1.000
301	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(29), ARHGEF1(1), F2(9), F2R(7), F2RL3(3), GNA12(3), GNA13(1), GNAI1(1), GNAQ(5), MAP3K7(1), PIK3CA(9), PIK3R1(7), PLCB1(52), PPP1R12B(8), PRKCA(11), PTK2B(11), ROCK1(5)	10013679	163	94	154	84	110	11	7	20	14	1	0.371	1.000	1.000
302	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	GORASP1(1), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(2), MAPK13(5), MAPK14(5), MAPK3(1), MAPK8(2), MAPK8IP1(5), MAPK8IP2(9), MAPK8IP3(9), MAPK9(7), MAPKAPK5(1), NFKB1(7), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PIK3CA(9), PIK3CD(7), PIK3R1(7), SYT1(20), TRAF2(3), TRAF3(5), TRAF5(7), TRAF6(5)	12946036	154	94	148	88	96	9	8	26	14	1	0.564	1.000	1.000
303	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), ATF1(5), CDC42(3), CREB3(1), CREB5(11), DUSP10(6), EEF2K(7), EIF4E(1), ELK1(2), HSPB1(2), IL1R1(12), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP3K10(8), MAP3K4(16), MAP3K5(18), MAP3K7(1), MAPK1(4), MAPK11(1), MAPK12(2), MAPK13(5), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MKNK1(5), MKNK2(2), MYEF2(4), NFKB1(7), NR2C2(2), SRF(2), TRAF6(5)	12892531	162	94	158	86	107	12	4	24	15	0	0.526	1.000	1.000
304	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(29), CD3D(5), CD3E(2), CD3G(1), CD4(6), CREBBP(23), CSK(1), GNAS(22), HLA-DRA(11), HLA-DRB1(4), LCK(14), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PTPRC(33), ZAP70(7)	8778424	181	93	174	99	125	14	8	18	16	0	0.480	1.000	1.000
305	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(29), CD3D(5), CD3E(2), CD3G(1), CD4(6), CREBBP(23), CSK(1), GNAS(22), HLA-DRA(11), HLA-DRB1(4), LCK(14), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PTPRC(33), ZAP70(7)	8778424	181	93	174	99	125	14	8	18	16	0	0.480	1.000	1.000
306	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(9), ADC(5), ALDH4A1(6), ALDH5A1(11), CAD(18), CPS1(22), EPRS(11), GAD1(15), GAD2(10), GCLC(5), GCLM(2), GFPT1(4), GFPT2(5), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(2), GMPS(6), GOT1(6), GOT2(7), GPT(3), GPT2(1), GSR(3), GSS(7), NADSYN1(4), NAGK(1), QARS(6)	15325230	180	93	173	94	104	22	11	28	15	0	0.363	1.000	1.000
307	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(4), ARSB(1), FUCA1(3), GALNS(4), GBA(5), GLB1(8), GNS(2), GUSB(4), HEXA(7), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(4), HYAL1(2), HYAL2(1), IDS(9), IDUA(4), LCT(43), MAN2B1(7), MAN2B2(8), MAN2C1(3), MANBA(7), NAGLU(4), NEU1(7), NEU2(14), NEU3(3), NEU4(9), SPAM1(23)	13222978	205	93	198	106	149	15	5	20	16	0	0.189	1.000	1.000
308	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(35), ACE2(8), AGT(6), AGTR1(11), AGTR2(12), ANPEP(18), CMA1(6), CPA3(18), CTSA(4), CTSG(4), ENPEP(33), LNPEP(10), MAS1(4), MME(21), NLN(5), REN(9), THOP1(7)	8163411	211	93	200	114	150	17	13	12	19	0	0.120	1.000	1.000
309	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(9), ACACA(21), ACADL(4), ACADM(6), ACADSB(6), ACAT2(1), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH6A1(5), ALDH9A1(3), ECHS1(2), EHHADH(7), HADHA(8), LDHA(6), LDHB(2), LDHC(5), MCEE(2), MLYCD(3), MUT(7), PCCA(5), PCCB(3), SDS(2), SUCLG1(2), SUCLG2(2)	12892648	152	93	147	73	97	13	10	23	9	0	0.391	1.000	1.000
310	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(6), BCL2(2), BIRC2(5), BIRC3(8), CASP10(5), CASP3(2), CASP7(5), CASP8(9), CASP9(3), CFLAR(4), CHUK(2), CYCS(1), DFFA(2), DFFB(3), GAS2(13), LMNA(9), MAP3K14(4), NFKB1(7), NFKBIA(2), RELA(5), RIPK1(1), SPTAN1(8), TNFRSF10A(5), TNFRSF10B(3), TNFRSF25(5), TNFSF10(8), TNFSF12(1), TRAF2(3)	12955017	131	92	129	78	75	17	10	20	9	0	0.867	1.000	1.000
311	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), EGF(19), EGFR(23), ELK1(2), FOS(2), GRB2(2), HRAS(4), JAK1(6), JUN(1), MAP2K1(13), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(2), PIK3CA(9), PIK3R1(7), PLCG1(9), PRKCA(11), RAF1(8), RASA1(4), SHC1(3), SOS1(9), SRF(2), STAT1(4), STAT3(11), STAT5A(3)	14508865	163	92	153	82	92	15	11	28	16	1	0.768	1.000	1.000
312	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(2), GTF2A1L(5), GTF2A2(1), GTF2B(3), GTF2E1(2), GTF2E2(5), GTF2F1(5), GTF2F2(2), GTF2H1(3), GTF2H3(1), GTF2H4(2), GTF2I(3), GTF2IRD1(9), STON1(1), TAF1(10), TAF13(2), TAF1L(59), TAF2(5), TAF4(9), TAF4B(3), TAF5L(3), TAF6(4), TAF6L(4), TAF7(2), TAF7L(11), TAF9(2), TAF9B(1), TBPL1(1), TBPL2(4)	14050445	164	92	158	70	113	13	6	23	9	0	0.286	1.000	1.000
313	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(22), CAMP(1), CASP3(2), CERK(1), CREB3(1), CREB5(11), DAG1(6), EPHB2(31), FOS(2), GNAQ(5), ITPKA(1), ITPKB(6), JUN(1), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(9), MAPK8(2), MAPK8IP1(5), MAPK8IP2(9), MAPK8IP3(9), MAPK9(7)	11016852	143	92	141	77	89	9	5	19	21	0	0.691	1.000	1.000
314	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(29), AKT1(3), BAX(3), BCL2(2), CSF2RB(18), IGF1(11), IGF1R(11), IL3(3), IL3RA(8), KIT(10), KITLG(9), PIK3CA(9), PIK3R1(7), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5)	8486341	146	91	140	85	91	13	9	13	19	1	0.516	1.000	1.000
315	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(11), BCAT2(2), COASY(3), DPYD(61), DPYS(24), ENPP1(13), ENPP3(15), ILVBL(4), PANK1(2), PANK2(3), PANK3(4), PANK4(6), PPCS(3), UPB1(6), VNN1(8)	6692519	165	91	149	50	118	13	5	17	12	0	0.000125	1.000	1.000
316	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(2), IFNA1(1), IFNB1(6), IKBKB(4), IL1A(4), IL1B(7), IL1R1(12), IL1RAP(4), IL1RN(8), IL6(2), IRAK1(5), IRAK2(14), IRAK3(7), JUN(1), MAP2K3(9), MAP2K6(3), MAP3K1(3), MAP3K14(4), MAP3K7(1), MAPK14(5), MAPK8(2), MYD88(3), NFKB1(7), NFKBIA(2), RELA(5), TGFB1(1), TGFB2(1), TGFB3(3), TNF(1), TOLLIP(1), TRAF6(5)	11423591	133	91	130	70	82	14	5	18	14	0	0.467	1.000	1.000
317	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(3), BCL2(2), CBL(11), CFLAR(4), CRKL(2), E2F1(7), FOS(2), GRB2(2), HRAS(4), IL2RA(4), IL2RB(7), IL2RG(3), IRS1(6), JAK1(6), JAK3(7), MAPK1(4), MAPK3(1), MYC(5), NMI(1), PIK3CA(9), PIK3R1(7), PPIA(1), PTPN6(3), RAF1(8), RPS6KB1(2), SHC1(3), SOCS3(2), SOS1(9), STAT5A(3), STAT5B(4), SYK(16)	13944714	148	91	145	73	80	13	13	22	19	1	0.527	1.000	1.000
318	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(22), AXIN1(11), CREBBP(23), CTNNB1(13), EP300(14), FZD1(4), GSK3B(2), HDAC1(1), LDB1(2), LEF1(3), PITX2(4), TRRAP(40), WNT1(2)	12887740	141	91	137	80	77	10	11	24	19	0	0.932	1.000	1.000
319	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(6), ABAT(9), ADSL(7), ADSS(2), AGXT(10), AGXT2(20), ASL(6), ASNS(9), ASPA(3), CAD(18), CRAT(6), DARS(4), DDO(7), GAD1(15), GAD2(10), GOT1(6), GOT2(7), GPT(3), GPT2(1), NARS(2), PC(13)	10140361	164	90	156	80	115	16	9	17	7	0	0.0480	1.000	1.000
320	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(7), ABAT(9), ACADS(4), ACAT2(1), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH5A1(11), ALDH9A1(3), ECHS1(2), EHHADH(7), GAD1(15), GAD2(10), HADHA(8), HMGCL(4), L2HGDH(3), OXCT1(5), PDHA1(3), PDHA2(19), PDHB(1), SDHB(1), SDS(2)	10054525	156	90	150	71	101	17	4	20	14	0	0.0666	1.000	1.000
321	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(10), ACO1(5), ACO2(5), CLYBL(5), CS(2), DLD(2), FH(3), IDH1(15), IDH2(2), IDH3A(3), IDH3B(1), IDH3G(2), MDH1(1), MDH2(4), OGDH(11), OGDHL(41), PC(13), PCK1(23), PCK2(4), SDHA(3), SDHB(1), SDHC(3), SDHD(1), SUCLG1(2), SUCLG2(2)	11634860	164	90	147	80	115	8	7	20	14	0	0.0958	1.000	1.000
322	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(5), AASDH(5), AASDHPPT(3), AASS(4), ACAT2(1), ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH9A1(3), BBOX1(5), DOT1L(11), ECHS1(2), EHHADH(7), EHMT1(8), EHMT2(9), GCDH(5), HADHA(8), PLOD1(5), PLOD2(7), PLOD3(5), SDS(2), SHMT1(1), SHMT2(3), TMLHE(2)	14269128	142	90	138	78	91	17	4	20	10	0	0.431	1.000	1.000
323	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(25), ATP4B(1), ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(20), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C2(9), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), ATP7A(9), ATP7B(19), COX10(6), COX5B(1), COX6A1(1), COX6B1(1), COX6C(1), COX7B(1), COX8A(1), NDUFA10(2), NDUFA4(1), NDUFB2(4), NDUFB5(3), NDUFB6(2), NDUFS2(2), NDUFV1(2), PPA2(3), SDHA(3), SDHB(1), SHMT1(1), UQCRC1(3), UQCRFS1(2)	14882681	166	90	165	99	100	9	19	22	16	0	0.785	1.000	1.000
324	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(2), POLA2(9), POLD1(6), POLD2(2), POLD3(4), POLE(16), POLE2(3), POLG(9), POLG2(7), POLH(3), POLI(4), POLK(6), POLL(7), POLM(2), POLQ(25), PRIM1(3), PRIM2(15), REV1(6), REV3L(13)	15703732	142	89	139	58	79	8	8	30	17	0	0.383	1.000	1.000
325	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(3), CASP10(5), CASP3(2), CASP7(5), CASP8(9), CFLAR(4), DAXX(10), DFFA(2), DFFB(3), FAF1(7), JUN(1), LMNA(9), LMNB1(2), LMNB2(4), MAP2K4(4), MAP3K1(3), MAP3K7(1), MAPK8(2), PAK1(4), PAK2(8), PRKDC(20), PTPN13(13), RB1(8), RIPK2(3), SPTAN1(8)	15899979	140	87	138	68	66	14	10	32	16	2	0.785	1.000	1.000
326	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(2), CREBBP(23), EP300(14), FYN(7), IL2RG(3), IL7(5), IL7R(33), JAK1(6), JAK3(7), LCK(14), NMI(1), PIK3CA(9), PIK3R1(7), PTK2B(11), STAT5A(3), STAT5B(4)	10809498	149	87	144	71	86	15	7	24	16	1	0.460	1.000	1.000
327	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(12), ABCC2(10), ABCG2(7), BCHE(6), CES1(16), CES2(5), CYP3A4(20), CYP3A5(10), UGT1A1(5), UGT1A10(15), UGT1A3(12), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(12), UGT1A8(7), UGT1A9(11)	8885713	172	87	161	78	118	15	11	11	17	0	0.00595	1.000	1.000
328	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(11), COASY(3), DPYD(61), DPYS(24), ENPP1(13), ENPP3(15), PANK1(2), PANK2(3), PANK3(4), PANK4(6), PPCS(3), UPB1(6)	5393414	151	87	135	44	106	13	5	16	11	0	0.000437	1.000	1.000
329	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(12), ATM(13), BRCA1(9), CDKN1A(4), CHEK1(2), CHEK2(2), JUN(1), MAPK8(2), MDM2(4), MRE11A(6), NFKB1(7), NFKBIA(2), RAD50(5), RAD51(1), RBBP8(5), RELA(5), TP53(43), TP73(5)	11514338	128	86	118	42	59	13	8	22	26	0	0.132	1.000	1.000
330	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(11), CSF1R(13), EGF(19), EGFR(23), GRB2(2), MET(23), PDGFRA(32), PRKCA(11), SH3GLB1(2), SH3GLB2(1), SH3KBP1(6), SRC(1)	7556092	144	86	143	83	92	13	9	16	14	0	0.773	1.000	1.000
331	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(17), FOS(2), HRAS(4), JUN(1), MAP2K1(13), MAPK1(4), MAPK3(1), MYC(5), NFKB1(7), NFKBIA(2), PLCB1(52), PRKCA(11), RAF1(8), RELA(5), TNF(1)	6038539	133	86	118	57	92	8	7	16	10	0	0.0440	1.000	1.000
332	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(3), CDT1(1), DIAPH2(7), MCM10(6), MCM2(11), MCM3(10), MCM4(7), MCM5(4), MCM6(5), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), POLA2(9), POLD1(6), POLD2(2), POLD3(4), POLE(16), POLE2(3), PRIM1(3), RFC1(7), RFC2(3), RFC3(1), RPA1(3), RPA2(2), RPA3(1), RPA4(2), RPS27A(2), UBB(1), UBC(6)	19630574	141	86	138	88	85	9	6	24	17	0	0.944	1.000	1.000
333	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(3), EIF4A1(3), EIF4A2(4), EIF4B(4), EIF4E(1), EIF4EBP1(1), EIF4G1(14), EIF4G2(5), EIF4G3(17), FKBP1A(2), MKNK1(5), PDK2(4), PDPK1(4), PIK3CA(9), PIK3R1(7), PPP2CA(1), PTEN(23), RPS6(1), RPS6KB1(2), TSC1(5), TSC2(12)	10727435	127	86	121	43	55	11	13	16	30	2	0.115	1.000	1.000
334	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(10), CCR2(17), CCR3(11), CCR4(8), CCR5(7), CCR7(3), CD28(1), CD4(6), CSF2(2), CXCR3(5), CXCR4(4), IFNG(2), IFNGR1(4), IFNGR2(4), IL12A(3), IL12B(4), IL12RB1(17), IL12RB2(3), IL18R1(17), IL2(4), IL4(1), IL4R(14), IL5(4), TGFB1(1), TGFB2(1), TGFB3(3)	7738919	156	86	149	85	112	13	1	15	15	0	0.0637	1.000	1.000
335	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(9), ALDH4A1(6), ALDH5A1(11), CAD(18), CPS1(22), EPRS(11), GAD1(15), GAD2(10), GCLC(5), GCLM(2), GFPT1(4), GLS(2), GLS2(3), GLUD1(2), GLUL(2), GMPS(6), GOT1(6), GOT2(7), GPT(3), GPT2(1), GSS(7), NADSYN1(4), QARS(6)	12887254	162	85	155	75	96	17	10	26	13	0	0.167	1.000	1.000
336	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(2), ALDOB(13), ALDOC(3), FBP1(2), FBP2(2), GOT1(6), GOT2(7), GPT(3), GPT2(1), MDH1(1), MDH2(4), ME1(20), ME3(11), PGK1(5), PGK2(29), PKLR(11), PKM2(5), RPIA(1), TKT(6), TKTL1(2), TKTL2(29)	7854047	163	85	150	85	118	15	5	15	10	0	0.0362	1.000	1.000
337	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(5), BAIAP2(7), CASP1(5), CASP3(2), CASP7(5), CASP8(9), GAPDH(3), INSR(22), ITCH(8), MAGI1(28), MAGI2(29), RERE(21), WWP1(3), WWP2(7)	9342211	154	85	150	70	104	10	3	23	13	1	0.380	1.000	1.000
338	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(5), ESR2(8), ITPKA(1), PDE1A(37), PDE1B(13), PLCB1(52), PLCB2(10), PRL(1), TRH(4), VIP(5)	4264127	136	85	121	59	108	4	3	13	8	0	0.0154	1.000	1.000
339	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(11), AGT(6), AGTR2(12), EDN1(9), EDNRA(9), EDNRB(5), EGF(19), EGFR(23), FOS(2), HRAS(4), JUN(1), MYC(5), NFKB1(7), PLCG1(9), PRKCA(11), RELA(5)	7959700	138	84	134	75	98	11	7	15	7	0	0.433	1.000	1.000
340	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(11), CSF1R(13), DDX20(8), E2F1(7), E2F4(1), ETS1(5), ETS2(9), ETV3(4), FOS(2), HDAC2(1), HDAC5(7), HRAS(4), JUN(1), NCOR2(26), RBL1(11), RBL2(6), SIN3A(12), SIN3B(7)	10063602	135	84	135	63	87	9	3	24	12	0	0.161	1.000	1.000
341	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(12), ARHGEF1(1), GNA12(3), GNA13(1), GNAQ(5), MYL2(5), MYLK(41), PLCB1(52), PPP1R12B(8), PRKCA(11), ROCK1(5)	8060574	144	84	131	71	111	4	6	15	8	0	0.328	1.000	1.000
342	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(16), ABP1(20), AOC2(8), AOC3(8), CES1(16), CES7(14), DDHD1(7), ESCO1(2), ESCO2(3), LIPA(4), MYST3(16), MYST4(16), NAT6(2), PLA1A(9), PNPLA3(2), PPME1(1), PRDX6(4), SH3GLB1(2)	9840541	150	83	145	85	107	8	10	13	12	0	0.806	1.000	1.000
343	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(3), AKT2(8), AKT3(4), BCL2(2), GRB2(2), GSK3B(2), IL4R(14), IRS1(6), IRS2(2), JAK1(6), JAK3(7), MAP4K1(9), MAPK1(4), MAPK3(1), PDK1(2), PIK3CA(9), PIK3CD(7), PIK3R1(7), PPP1R13B(8), RAF1(8), SHC1(3), SOS1(9), SOS2(13), STAT6(8)	14154973	144	83	143	56	78	17	7	24	17	1	0.0737	1.000	1.000
344	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(6), CHAT(15), COMT(3), DBH(14), DDC(12), GAD1(15), GAD2(10), HDC(22), MAOA(4), PAH(9), PNMT(4), SLC18A3(3), TH(9), TPH1(9)	5473900	136	82	130	78	109	10	4	5	8	0	0.116	1.000	1.000
345	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(3), APAF1(6), ATM(13), BAX(3), BCL2(2), CASP3(2), CASP7(5), CASP9(3), CYCS(1), EIF2S1(1), PRKCA(11), PTK2(8), PXN(3), STAT1(4), TLN1(14), TP53(43)	10589263	122	82	111	42	61	11	9	16	25	0	0.0321	1.000	1.000
346	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(1), ARSD(3), ARSE(5), GAL3ST1(9), GALC(4), GBA(5), GLA(1), GLB1(8), LCT(43), NEU1(7), NEU2(14), NEU3(3), NEU4(9), PPAP2B(9), PPAP2C(8), SMPD1(3), SMPD2(2), SPTLC1(1), SPTLC2(6), UGCG(2)	9284804	143	82	135	88	101	13	2	18	9	0	0.734	1.000	1.000
347	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), AKR1B10(8), ALDOA(2), ALDOB(13), ALDOC(3), FBP1(2), FBP2(2), FPGT(2), FUK(3), GMDS(5), GMPPA(2), GMPPB(3), HK1(3), HK2(12), HK3(15), HSD3B7(3), KHK(1), LHPP(1), MPI(1), MTMR1(4), MTMR2(3), MTMR6(2), PFKFB1(4), PFKFB2(6), PFKFB3(2), PFKFB4(5), PFKL(4), PFKM(2), PGM2(7), PMM1(2), PMM2(1), RDH11(2), RDH12(2), RDH13(3), SORD(2), TSTA3(2)	14304259	136	82	132	95	92	15	10	12	7	0	0.651	1.000	1.000
348	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(41), ABCB11(46), ABCB4(19), ABCC1(12), ABCC3(28), GSTP1(2)	5514338	148	82	140	75	100	15	5	12	16	0	0.00841	1.000	1.000
349	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(22), AXIN1(11), BTRC(5), CCND1(1), CREBBP(23), CSNK1A1(3), CSNK1D(1), CSNK2A1(1), CTNNB1(13), FZD1(4), GSK3B(2), HDAC1(1), MAP3K7(1), MYC(5), NLK(6), PPARD(3), PPP2CA(1), TLE1(5), WIF1(8), WNT1(2)	11315880	118	82	117	59	61	7	10	19	21	0	0.792	1.000	1.000
350	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(18), G6PD(4), GCLC(5), GCLM(2), GGT1(7), GPX1(3), GPX3(3), GPX5(13), GPX6(16), GSR(3), GSS(7), GSTA1(5), GSTA2(2), GSTA3(1), GSTA5(3), GSTK1(2), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTP1(2), GSTT1(1), IDH1(15), IDH2(2), MGST1(2), MGST2(2), MGST3(1), OPLAH(10), TXNDC12(1)	8469081	146	81	131	77	104	8	7	19	8	0	0.0666	1.000	1.000
351	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(6), ICAM1(3), ITGA4(38), ITGAL(24), ITGB1(4), ITGB2(14), SELE(36), SELL(8)	4649501	133	81	129	40	97	4	5	9	18	0	0.00154	1.000	1.000
352	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(2), CREBBP(23), EP300(14), IKBKB(4), IL1B(7), IL8(1), MAP2K3(9), MAP2K6(3), MAP3K14(4), MAP3K7(1), MAPK11(1), MAPK14(5), MYD88(3), NFKB1(7), NFKBIA(2), NR3C1(7), RELA(5), TGFBR2(7), TLR2(17), TNF(1)	11516979	123	81	122	70	72	16	6	21	8	0	0.897	1.000	1.000
353	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(41), AKT1(3), ATM(13), BAX(3), CDKN1A(4), CPB2(1), CSNK1A1(3), CSNK1D(1), HIC1(1), HIF1A(5), IGFBP3(2), MAPK8(2), MDM2(4), NFKBIB(1), NQO1(1), TP53(43)	8067850	128	81	113	46	67	9	8	18	26	0	0.109	1.000	1.000
354	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(5), ACTN1(5), ACTN2(24), ACTN3(7), CAPN1(4), CAPNS1(1), ITGA1(18), ITGB1(4), ITGB3(12), PTK2(8), PXN(3), RAC1(17), SPTAN1(8), SRC(1), TLN1(14)	10915877	131	81	118	67	88	9	5	14	14	1	0.0686	1.000	1.000
355	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(4), CSNK1D(1), DRD1(11), DRD2(17), GRM1(17), PLCB1(52), PPP1CA(2), PPP1R1B(2), PPP2CA(1), PPP3CA(5), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5)	6177258	135	80	128	85	100	5	7	12	11	0	0.626	1.000	1.000
356	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPAT6(3), AGPS(5), CHPT1(1), ENPP2(2), ENPP6(11), PAFAH1B1(4), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(2), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(7), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11), PLD1(12), PLD2(7), PPAP2B(9), PPAP2C(8)	9045845	149	80	142	81	96	11	5	20	17	0	0.493	1.000	1.000
357	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(5), ADCY1(29), CAP1(1), CDC25C(5), GNAI1(1), GNAS(22), HRAS(4), MAPK1(4), MAPK3(1), MYT1(22), PIN1(1), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RPS6KA1(9), SRC(1)	7940787	128	80	123	90	91	9	5	9	14	0	0.880	1.000	1.000
358	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), ERCC3(5), GTF2A2(1), GTF2B(3), GTF2E1(2), GTF2E2(5), GTF2F2(2), GTF2H1(3), GTF2H4(2), MNAT1(2), POLR1A(11), POLR1B(9), POLR2A(12), POLR2B(11), POLR2C(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR3B(15), POLR3D(1), POLR3E(5), POLR3H(2), POLR3K(1), TAF13(2), TAF6(4), TAF7(2), TAF9(2), TBP(4)	13633174	116	80	114	50	69	10	9	19	9	0	0.250	1.000	1.000
359	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(1), FOS(2), GRB2(2), HRAS(4), JAK2(9), JUN(1), MAP2K1(13), MAPK3(1), MPL(8), PIK3CA(9), PIK3R1(7), PLCG1(9), PRKCA(11), RAF1(8), RASA1(4), SHC1(3), SOS1(9), STAT1(4), STAT3(11), STAT5A(3), STAT5B(4), THPO(8)	11584552	131	80	121	55	71	12	9	25	13	1	0.376	1.000	1.000
360	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(2), ALDOB(13), ALDOC(3), DERA(2), FBP1(2), FBP2(2), G6PD(4), GPI(3), H6PD(7), PFKL(4), PFKM(2), PGD(8), PGLS(1), PGM1(4), PGM3(4), PRPS1(2), PRPS1L1(14), PRPS2(4), RBKS(4), RPIA(1), TALDO1(3), TKT(6), TKTL1(2), TKTL2(29)	9391853	126	79	120	78	82	13	5	12	14	0	0.357	1.000	1.000
361	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(13), CDC25A(8), CDC25B(6), CDC25C(5), CDK4(5), CHEK1(2), MYT1(22), RB1(8), TP53(43), WEE1(3)	6827771	115	79	103	33	54	7	7	17	28	2	0.0214	1.000	1.000
362	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CALM2(1), CHUK(2), EGR2(4), EGR3(2), GNAQ(5), MAP3K1(3), MYC(5), NFATC1(15), NFATC2(9), NFKB1(7), NFKBIA(2), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RELA(5), SYT1(20), VIP(5), VIPR2(5)	10807472	134	79	130	87	89	11	7	16	11	0	0.944	1.000	1.000
363	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(35), AGT(6), AGTR1(11), AGTR2(12), BDKRB2(10), KNG1(14), NOS3(17), REN(9)	3832959	114	78	106	69	79	7	6	12	10	0	0.194	1.000	1.000
364	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(3), BCL2(2), BCR(11), CRKL(2), FOS(2), GRB2(2), HRAS(4), JAK2(9), JUN(1), MAP2K1(13), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(2), MYC(5), PIK3CA(9), PIK3R1(7), RAF1(8), SOS1(9), STAT1(4), STAT5A(3), STAT5B(4)	10839868	108	78	99	46	56	9	7	21	14	1	0.405	1.000	1.000
365	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(3), EIF2B5(1), EIF2S1(1), EIF4E(1), EIF4EBP1(1), GSK3B(2), IGF1(11), IGF1R(11), INPPL1(15), PDK2(4), PDPK1(4), PIK3CA(9), PIK3R1(7), PPP2CA(1), PTEN(23), RPS6(1), RPS6KB1(2)	7612850	97	78	91	37	43	8	10	12	23	1	0.276	1.000	1.000
366	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(4), GALNT10(6), GALNT2(6), GALNT3(3), GALNT4(6), GALNT6(17), GALNT7(5), GALNT8(24), GALNT9(5), GCNT1(7), ST3GAL1(6), ST3GAL2(1), ST3GAL4(1), WBSCR17(39)	5619136	130	78	122	61	98	8	5	9	10	0	0.117	1.000	1.000
367	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(3), CASP9(3), CDC42(3), CHUK(2), ELK1(2), H2AFX(2), HRAS(4), MAP2K1(13), MAPK3(1), NFKB1(7), PIK3CA(9), PIK3R1(7), RAC1(17), RAF1(8), RALA(1), RALBP1(2), RALGDS(8), RELA(5), RHOA(1)	7319844	98	78	80	44	58	10	3	19	7	1	0.330	1.000	1.000
368	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(4), DAB1(42), FYN(7), LRP8(3), RELN(76), VLDLR(5)	5420606	137	78	130	73	98	7	4	12	16	0	0.813	1.000	1.000
369	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(19), EGFR(23), MAP2K1(13), MAP3K1(3), MAPK14(5), NCOR2(26), RARA(3), RXRA(4), THRA(4), THRB(17)	6645093	117	77	109	59	82	9	5	14	7	0	0.386	1.000	1.000
370	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(3), CHIA(9), CHIT1(13), CMAS(2), CTBS(6), CYB5R1(1), GFPT1(4), GFPT2(5), GNE(3), GNPDA2(1), HEXA(7), HEXB(4), HK1(3), HK2(12), HK3(15), LHPP(1), MTMR1(4), MTMR2(3), MTMR6(2), NAGK(1), NANS(1), PGM3(4), RENBP(3), UAP1(2)	11106248	109	77	107	63	70	9	6	14	10	0	0.637	1.000	1.000
371	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(29), ADRB2(2), GNAS(22), PLCE1(53), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5)	5657622	129	77	122	74	89	9	7	13	11	0	0.614	1.000	1.000
372	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(3), CCND1(1), CCNE1(4), CDK4(5), CDK6(3), CDKN1A(4), CDKN1B(1), E2F1(7), HRAS(4), MAPK1(4), MAPK3(1), NFKB1(7), NFKBIA(2), PAK1(4), PIK3CA(9), PIK3R1(7), RAC1(17), RAF1(8), RB1(8), RELA(5), TFDP1(3)	7808329	107	77	96	40	54	7	7	21	15	3	0.0879	1.000	1.000
373	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(9), AKR1D1(20), CYP11A1(15), CYP11B1(16), CYP11B2(14), CYP17A1(7), CYP21A2(15), HSD11B1(11), HSD11B2(2), HSD3B1(10), HSD3B2(11)	3787288	130	76	118	62	90	11	5	13	11	0	0.00331	1.000	1.000
374	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(2), AKT1(3), ANXA1(4), CALM1(1), CALM2(1), GNAS(22), NFKB1(7), NOS3(17), NPPA(3), NR3C1(7), PIK3CA(9), PIK3R1(7), RELA(5), SYT1(20)	6887561	108	76	101	64	77	6	3	15	6	1	0.886	1.000	1.000
375	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(18), G6PD(4), GCLC(5), GCLM(2), GGT1(7), GPX1(3), GPX3(3), GPX5(13), GSS(7), GSTA1(5), GSTA2(2), GSTA3(1), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTP1(2), GSTT1(1), IDH1(15), IDH2(2), MGST1(2), MGST2(2), MGST3(1), PGD(8)	7000641	119	76	105	52	82	6	7	17	7	0	0.0115	1.000	1.000
376	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(9), AKR1D1(20), CYP11A1(15), CYP11B1(16), CYP11B2(14), CYP17A1(7), CYP21A2(15), HSD11B1(11), HSD11B2(2), HSD3B1(10), HSD3B2(11)	3787288	130	76	118	62	90	11	5	13	11	0	0.00331	1.000	1.000
377	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(24), PGAP1(5), PIGA(3), PIGB(4), PIGC(3), PIGF(2), PIGG(10), PIGH(1), PIGK(6), PIGL(2), PIGM(2), PIGN(4), PIGO(13), PIGQ(8), PIGS(1), PIGT(1), PIGU(7), PIGV(7), PIGW(2), PIGX(2), PIGZ(3)	9277664	111	76	109	49	63	9	8	21	10	0	0.115	1.000	1.000
378	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(4), IL2(4), IL2RA(4), IL2RB(7), IL2RG(3), JAK1(6), JAK3(7), JUN(1), LCK(14), MAP2K1(13), MAPK3(1), MAPK8(2), RAF1(8), SHC1(3), SOS1(9), STAT5A(3), STAT5B(4), SYK(16)	8918975	116	76	106	49	72	10	7	18	9	0	0.112	1.000	1.000
379	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CALM2(1), CAMK1(5), CAMK1G(11), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CAMK4(12), ESRRA(3), HDAC5(7), MEF2A(5), MEF2B(3), MEF2C(3), MEF2D(5), PPARA(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), SLC2A4(8), SYT1(20)	7773686	124	76	116	75	91	7	3	13	10	0	0.582	1.000	1.000
380	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(3), BAG4(4), CASP2(1), CASP3(2), CASP8(9), CRADD(1), DFFA(2), DFFB(3), JUN(1), LMNA(9), LMNB1(2), LMNB2(4), MADD(15), MAP2K4(4), MAP3K1(3), MAP3K7(1), MAPK8(2), PAK1(4), PAK2(8), PRKDC(20), RB1(8), RIPK1(1), SPTAN1(8), TNF(1), TNFRSF1A(3), TRAF2(3)	15099110	122	76	119	58	57	13	9	25	16	2	0.519	1.000	1.000
381	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(29), ADRB2(2), CFTR(46), GNAS(22), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), SLC9A3R1(3)	5015219	125	75	117	84	87	8	6	10	14	0	0.869	1.000	1.000
382	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(23), DAXX(10), HRAS(4), PAX3(4), PML(3), RARA(3), RB1(8), SP100(10), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TP53(43)	7292160	115	75	106	35	51	10	11	16	25	2	0.0137	1.000	1.000
383	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GALNS(4), GLB1(8), GNS(2), GUSB(4), HEXA(7), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(4), HYAL1(2), HYAL2(1), IDS(9), IDUA(4), LCT(43), NAGLU(4), SPAM1(23)	7878999	135	74	128	77	102	7	2	12	12	0	0.508	1.000	1.000
384	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(4), IGF1(11), IGF1R(11), IRS1(6), JUN(1), MAP2K1(13), MAPK3(1), MAPK8(2), PIK3CA(9), PIK3R1(7), PTPN11(10), RAF1(8), RASA1(4), SHC1(3), SOS1(9), SRF(2)	9601251	108	74	96	44	53	16	4	22	12	1	0.385	1.000	1.000
385	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(3), PIK3CA(9), PIK3R1(7), PLCB1(52), PLCG1(9), PRKCA(11), VAV1(16)	4987502	107	74	100	55	80	3	4	10	9	1	0.422	1.000	1.000
386	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(5), DYRK1B(2), GLI2(38), GLI3(17), GSK3B(2), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), SHH(5), SMO(11), SUFU(3)	6424837	106	74	103	60	70	12	7	8	9	0	0.511	1.000	1.000
387	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(5), EPHA4(19), EPHB1(27), FYN(7), ITGA1(18), ITGB1(4), L1CAM(9), LYN(7), RAP1B(1), SELP(31)	6119862	128	73	117	71	93	5	2	17	11	0	0.588	1.000	1.000
388	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(4), INSR(22), IRS1(6), JUN(1), MAP2K1(13), MAPK3(1), MAPK8(2), PIK3CA(9), PIK3R1(7), PTPN11(10), RAF1(8), RASA1(4), SHC1(3), SLC2A4(8), SOS1(9), SRF(2)	9927212	116	73	105	49	53	14	5	29	14	1	0.493	1.000	1.000
389	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(5), CS(2), DLAT(2), DLD(2), FH(3), IDH2(2), IDH3A(3), IDH3B(1), IDH3G(2), MDH1(1), MDH2(4), OGDH(11), PC(13), PDHA1(3), PDHA2(19), PDHB(1), PDHX(2), PDK1(2), PDK2(4), PDK3(4), PDK4(9), PDP2(6), SDHA(3), SDHB(1), SDHC(3), SDHD(1), SUCLG1(2), SUCLG2(2)	11039106	113	73	108	55	76	7	6	12	12	0	0.283	1.000	1.000
390	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(7), GBA3(14), LPO(18), MPO(11), PRDX1(2), PRDX2(2), PRDX6(4), TPO(45), TYR(8)	3747383	111	73	105	58	87	9	1	5	9	0	0.118	1.000	1.000
391	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(29), GNAS(22), PPP2CA(1), PRKAA1(1), PRKAA2(26), PRKAB1(2), PRKAB2(2), PRKACB(4), PRKACG(8), PRKAG1(2), PRKAG2(9), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5)	5916203	117	72	109	67	84	9	7	4	13	0	0.660	1.000	1.000
392	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(3), MAP2K1(13), MAP2K2(4), MAP2K3(9), MAP2K6(3), MAP3K1(3), MAPK1(4), MAPK14(5), MAPK3(1), NFKB1(7), PIK3CA(9), PIK3R1(7), RB1(8), RELA(5), SP1(5)	7496657	86	72	76	42	41	8	5	14	15	3	0.730	1.000	1.000
393	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(5), CARM1(6), CBS(7), CTH(1), GGT1(7), HEMK1(5), LCMT1(4), MARS(6), MARS2(4), MAT1A(5), MAT2B(3), METTL2B(8), METTL6(3), PAPSS1(3), PAPSS2(5), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), SCLY(3), SEPHS1(4), SEPHS2(2), WBSCR22(1)	9726533	106	72	104	48	65	11	5	17	8	0	0.108	1.000	1.000
394	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(5), ACTR2(3), ACTR3(2), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), NCK1(1), NCKAP1(7), NTRK1(19), PIR(1), RAC1(17), WASF1(5), WASF2(5), WASF3(12), WASL(5)	5939608	89	71	79	29	60	8	2	11	8	0	0.0685	1.000	1.000
395	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(8), GABRA1(16), GABRA2(16), GABRA3(19), GABRA4(13), GABRA5(3), GABRA6(24), GPHN(9), NSF(1), SRC(1), UBQLN1(6)	4552114	116	71	104	60	88	4	5	11	7	1	0.305	1.000	1.000
396	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(12), CYP2A13(12), CYP2A6(12), CYP2A7(8), NAT1(2), NAT2(10), XDH(56)	3117366	112	71	106	67	89	5	8	5	5	0	0.0583	1.000	1.000
397	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(7), CD3D(5), CD3E(2), CD3G(1), CXCR3(5), ETV5(7), IFNG(2), IL12A(3), IL12B(4), IL12RB1(17), IL12RB2(3), IL18(2), IL18R1(17), JAK2(9), JUN(1), MAP2K6(3), MAPK14(5), MAPK8(2), STAT4(22), TYK2(8)	7194305	125	71	122	65	86	9	4	15	11	0	0.552	1.000	1.000
398	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(11), APOA1(2), APOA4(8), APOC1(2), APOC2(1), APOE(1), CETP(7), CYP7A1(9), DGAT1(1), HMGCR(18), LDLR(16), LIPC(9), LPL(3), LRP1(40), SCARB1(5), SOAT1(3)	10719027	136	71	127	69	79	14	7	22	14	0	0.187	1.000	1.000
399	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(22), CDH1(7), CREBBP(23), EP300(14), MAP2K1(13), MAP3K7(1), MAPK3(1), SKIL(2), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(7)	9980763	95	71	87	44	57	8	3	15	12	0	0.776	1.000	1.000
400	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(9), ASRGL1(3), CA1(10), CA12(3), CA13(5), CA2(10), CA3(5), CA4(4), CA5A(2), CA5B(1), CA6(4), CA7(2), CA8(4), CA9(8), CPS1(22), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(2), HAL(12)	8172092	120	70	118	53	81	10	4	14	11	0	0.125	1.000	1.000
401	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(2), IKBKB(4), IL1A(4), IL1R1(12), IRAK1(5), MAP3K1(3), MAP3K14(4), MAP3K7(1), MYD88(3), NFKB1(7), NFKBIA(2), RELA(5), RIPK1(1), TLR4(34), TNF(1), TNFAIP3(2), TNFRSF1A(3), TNFRSF1B(3), TRAF6(5)	9295489	101	70	98	62	68	10	5	10	8	0	0.814	1.000	1.000
402	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(5), GTF2A1(2), GTF2B(3), GTF2E1(2), GTF2F1(5), HDAC3(6), NCOA1(10), NCOA2(13), NCOA3(17), NCOR2(26), POLR2A(12), RARA(3), RXRA(4), TBP(4)	9627497	112	70	110	48	84	4	5	11	8	0	0.132	1.000	1.000
403	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(35), CD44(6), CSF1(11), FCGR3A(9), IL1B(7), IL6R(4), SELL(8), SPN(6), TGFB1(1), TGFB2(1), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TNFRSF8(20), TNFSF8(4)	5015941	119	70	113	51	87	6	6	6	14	0	0.0270	1.000	1.000
404	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(3), AKT2(8), AKT3(4), GRB2(2), MAPK1(4), MAPK3(1), PDK1(2), PIK3CA(9), PIK3CD(7), PTEN(23), PTK2B(11), RBL2(6), SHC1(3), SOS1(9)	7955283	92	70	88	35	39	7	6	19	21	0	0.362	1.000	1.000
405	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(2), ALDOB(13), ALDOC(3), FBP1(2), FBP2(2), FPGT(2), GCK(20), GMDS(5), GMPPA(2), GMPPB(3), HK1(3), HK2(12), HK3(15), KHK(1), MPI(1), PFKFB1(4), PFKFB3(2), PFKFB4(5), PFKM(2), PMM1(2), PMM2(1), SORD(2)	9228871	106	69	101	76	76	15	6	4	5	0	0.497	1.000	1.000
406	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(24), BST1(1), CD38(4), ENPP1(13), ENPP3(15), NADK(4), NADSYN1(4), NMNAT2(3), NMNAT3(8), NNMT(9), NNT(3), NT5C1A(3), NT5C1B(24), NT5C2(3), NT5C3(2), NT5E(4), NT5M(2), NUDT12(1), QPRT(6)	8358721	133	69	128	71	86	12	7	13	15	0	0.524	1.000	1.000
407	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(7), GBA(5), GBA3(14), LPO(18), MPO(11), PRDX6(4), TPO(45)	3253090	104	69	98	55	82	8	1	6	7	0	0.0832	1.000	1.000
408	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CALM2(1), CDKN1A(4), GNAQ(5), MARCKS(1), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(11), SP1(5), SP3(1), SYT1(20)	8112212	115	68	110	55	77	10	6	12	10	0	0.410	1.000	1.000
409	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(5), ACTN2(24), ACTN3(7), BCAR1(5), CSK(1), CTNNA1(2), CTNNA2(27), CTNNB1(13), PTK2(8), PXN(3), SRC(1), VCL(7)	7315183	103	68	98	56	65	7	5	13	12	1	0.247	1.000	1.000
410	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(5), ALOX15(9), ALOX15B(10), ALOX5(9), ALOX5AP(1), DPEP1(5), GGT1(7), LTA4H(4), PLA2G2A(2), PLA2G6(11), PTGDS(2), PTGIS(12), PTGS1(17), PTGS2(11), TBXAS1(14)	5783075	119	68	114	73	85	10	2	12	10	0	0.194	1.000	1.000
411	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(11), BCAT2(2), IARS(8), IARS2(14), ILVBL(4), LARS(10), LARS2(5), PDHA1(3), PDHA2(19), PDHB(1), VARS(18), VARS2(6)	7323207	101	68	89	42	66	11	3	12	9	0	0.145	1.000	1.000
412	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(4), FUCA1(3), GLB1(8), HEXA(7), HEXB(4), LCT(43), MAN2B1(7), MAN2B2(8), MAN2C1(3), MANBA(7), NEU1(7), NEU2(14), NEU3(3), NEU4(9)	7858351	127	68	122	64	96	11	3	12	5	0	0.179	1.000	1.000
413	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(3), BCAR1(5), CDKN1B(1), GRB2(2), ITGB1(4), MAPK1(4), MAPK3(1), PDK2(4), PDPK1(4), PIK3CA(9), PIK3R1(7), PTEN(23), PTK2(8), SHC1(3), SOS1(9)	7427491	87	68	82	32	38	5	6	15	22	1	0.439	1.000	1.000
414	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(6), CARS(10), DARS(4), EPRS(11), FARS2(5), GARS(6), HARS(6), IARS(8), KARS(6), LARS(10), LARS2(5), MARS(6), MARS2(4), NARS(2), QARS(6), RARS(7), SARS(10), TARS(2), WARS(4), WARS2(4), YARS(1)	12508890	123	67	116	54	77	12	7	17	10	0	0.220	1.000	1.000
415	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(10), CARS2(2), CDO1(6), CTH(1), GOT1(6), GOT2(7), LDHA(6), LDHAL6A(5), LDHAL6B(7), LDHB(2), LDHC(5), MPST(2), SDS(2), SULT1B1(11), SULT1C2(6), SULT1C4(12), SULT4A1(9)	4876626	99	67	94	31	69	3	9	8	10	0	0.00242	1.000	1.000
416	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(1), ATG5(3), ATG7(8), BECN1(4), GABARAPL1(1), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(10), IFNA17(2), IFNA2(1), IFNA21(9), IFNA4(1), IFNA5(3), IFNA6(3), IFNA7(5), IFNA8(3), IFNG(2), PIK3C3(3), PIK3R4(7), PRKAA1(1), PRKAA2(26), ULK1(8), ULK2(7), ULK3(1)	8100530	119	67	113	64	85	8	6	14	6	0	0.474	1.000	1.000
417	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(18), FOS(2), GRB2(2), HRAS(4), IL3(3), IL3RA(8), JAK2(9), MAP2K1(13), MAPK3(1), PTPN6(3), RAF1(8), SHC1(3), SOS1(9), STAT5A(3), STAT5B(4)	6808795	90	67	82	42	53	4	5	16	12	0	0.404	1.000	1.000
418	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(4), IL6(2), IL6R(4), IL6ST(10), JAK1(6), JAK2(9), JAK3(7), JUN(1), MAP2K1(13), MAPK3(1), PTPN11(10), RAF1(8), SHC1(3), SOS1(9), SRF(2), STAT3(11)	9218757	107	67	97	46	50	13	5	27	12	0	0.510	1.000	1.000
419	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(21), CPT1A(11), LEP(2), LEPR(25), PRKAA1(1), PRKAA2(26), PRKAB1(2), PRKAB2(2), PRKAG1(2), PRKAG2(9)	5664436	101	67	93	53	72	6	4	6	13	0	0.654	1.000	1.000
420	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(2), ALDOB(13), ALDOC(3), FBP1(2), FBP2(2), G6PD(4), GPI(3), H6PD(7), PFKM(2), PGD(8), PGLS(1), PGM1(4), PGM3(4), PRPS1(2), PRPS1L1(14), PRPS2(4), RBKS(4), RPIA(1), TAL1(7), TALDO1(3), TKT(6)	7912863	96	67	93	63	61	8	5	10	12	0	0.570	1.000	1.000
421	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(13), ATR(25), CDC25C(5), CHEK1(2), CHEK2(2), TP53(43)	6210627	90	67	80	26	46	3	7	12	22	0	0.105	1.000	1.000
422	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), AP2A1(1), AP2M1(3), BTK(17), EEA1(4), GRASP(1), GSK3B(2), LYN(7), PDPK1(4), PFKL(4), PFKM(2), PLCG1(9), PRKCE(6), PRKCZ(6), RAB5A(1), RAC1(17), RPS6KB1(2), VAV2(4)	9583374	93	67	82	47	58	5	5	13	12	0	0.169	1.000	1.000
423	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(5), ACO2(5), CS(2), DLD(2), FH(3), IDH1(15), IDH2(2), IDH3A(3), IDH3B(1), IDH3G(2), MDH1(1), MDH2(4), PC(13), PCK1(23), SDHA(3), SDHB(1), SUCLG1(2), SUCLG2(2)	8044341	89	66	75	50	65	3	6	9	6	0	0.448	1.000	1.000
424	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD3D(5), CD3E(2), CD3G(1), CD80(5), CD86(21), CTLA4(2), GRB2(2), HLA-DRA(11), HLA-DRB1(4), ICOS(3), IL2(4), ITK(21), LCK(14), PIK3CA(9), PIK3R1(7), PTPN11(10)	4957431	122	66	115	45	78	8	3	17	15	1	0.113	1.000	1.000
425	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(1), ERBB4(50), NRG2(7), NRG3(21), PRKCA(11), PSEN1(1)	3457779	91	66	82	34	70	4	2	6	9	0	0.0520	1.000	1.000
426	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(3), CAT(6), EPX(7), LPO(18), MPO(11), PRDX1(2), PRDX2(2), PRDX6(4), SHMT1(1), SHMT2(3), TPO(45)	4588990	102	66	98	56	80	9	1	7	5	0	0.132	1.000	1.000
427	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(6), ICAM1(3), ITGAL(24), ITGAM(21), ITGB2(14), SELE(36), SELL(8)	3980549	112	66	112	41	81	4	3	7	17	0	0.00336	1.000	1.000
428	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(9), CA1(10), CA12(3), CA2(10), CA3(5), CA4(4), CA5A(2), CA5B(1), CA6(4), CA7(2), CA8(4), CA9(8), CPS1(22), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUL(2), HAL(12)	7306567	108	66	106	47	73	8	3	14	10	0	0.123	1.000	1.000
429	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(3), CNR1(9), CNR2(4), DNMT1(19), MTNR1A(8), MTNR1B(7), PTAFR(2), PTGDR(9), PTGER2(6), PTGER4(1), PTGFR(22), PTGIR(6), TBXA2R(4)	4322111	100	66	95	76	67	12	5	8	8	0	0.431	1.000	1.000
430	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(11), CALM1(1), CALM2(1), CAPN2(6), CAPNS1(1), EP300(14), HDAC1(1), HDAC2(1), MEF2D(5), NFATC1(15), NFATC2(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(11), SYT1(20)	9512402	107	65	102	55	75	7	7	10	8	0	0.539	1.000	1.000
431	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(7), CD2(23), CD3D(5), CD3E(2), CD3G(1), CD4(6), CXCR3(5), IFNG(2), IL12A(3), IL12B(4), IL12RB1(17), IL12RB2(3), JAK2(9), STAT4(22), TYK2(8)	5639582	117	65	111	61	77	12	4	13	11	0	0.349	1.000	1.000
432	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(6), BIRC2(5), BIRC3(8), CASP10(5), CASP3(2), CASP7(5), CASP8(9), CASP9(3), DFFA(2), DFFB(3), GZMB(3), PRF1(13), SCAP(8), SREBF1(5), SREBF2(10)	7059931	87	65	83	43	52	7	7	12	9	0	0.448	1.000	1.000
433	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(2), ALDOB(13), ALDOC(3), FBP1(2), FBP2(2), GOT1(6), GOT2(7), GPT(3), GPT2(1), MDH1(1), MDH2(4), ME1(20), ME2(1), ME3(11), PGK1(5), PKLR(11), PKM2(5), RPIA(1), TKT(6)	7017484	104	64	101	54	73	8	5	9	9	0	0.103	1.000	1.000
434	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(16), GABRA2(16), GABRA3(19), GABRA4(13), GABRA5(3), GABRA6(24), GPX1(3), PRKCE(6)	2997250	100	64	88	50	75	5	3	10	6	1	0.220	1.000	1.000
435	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(3), GSR(3), GSS(7), IL8(1), NFKB1(7), NOX1(11), RELA(5), TNF(1), XDH(56)	3828590	94	64	91	42	73	7	4	7	3	0	0.0383	1.000	1.000
436	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(5), BHMT(9), CBS(7), CTH(1), DNMT1(19), DNMT3A(6), DNMT3B(10), MARS(6), MARS2(4), MAT1A(5), MAT2B(3), MTAP(4), MTFMT(2), MTR(10), TAT(17)	8133778	108	64	104	45	70	6	8	14	10	0	0.0730	1.000	1.000
437	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(16), AP2A1(1), AP2M1(3), BIN1(5), CALM1(1), CALM2(1), DNM1(8), EPN1(6), EPS15(3), PICALM(1), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYNJ1(23), SYNJ2(16), SYT1(20)	8293541	115	64	110	57	82	10	2	16	5	0	0.388	1.000	1.000
438	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(9), PARK2(9), SNCA(2), SNCAIP(54), UBE2E2(4), UBE2F(5), UBE2G2(1), UBE2L6(2)	2499759	86	64	77	32	65	9	2	4	6	0	0.0471	1.000	1.000
439	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(3), GRB2(2), HRAS(4), IGF1R(11), IRS1(6), MAP2K1(13), MAPK1(4), MAPK3(1), PIK3CA(9), PIK3R1(7), RAF1(8), SHC1(3), SOS1(9)	7379970	80	63	71	32	42	8	4	14	11	1	0.289	1.000	1.000
440	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(3), CAT(6), GH1(3), GHR(30), HRAS(4), IGF1(11), IGF1R(11), PIK3CA(9), PIK3R1(7), SHC1(3)	5148532	87	63	82	41	58	9	2	9	8	1	0.326	1.000	1.000
441	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(4), FUCA1(3), GLB1(8), HEXA(7), HEXB(4), LCT(43), MAN2C1(3), MANBA(7), NEU1(7), NEU2(14), NEU3(3), NEU4(9)	6378613	112	63	107	57	85	9	2	11	5	0	0.307	1.000	1.000
442	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(21), HLA-DRA(11), HLA-DRB1(4), IFNG(2), IFNGR1(4), IFNGR2(4), IL12A(3), IL12B(4), IL12RB1(17), IL12RB2(3), IL18(2), IL18R1(17), IL2(4), IL2RA(4), IL4(1), IL4R(14)	4908856	116	63	110	49	86	6	0	9	15	0	0.0758	1.000	1.000
443	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(3), CAT(6), EPX(7), LPO(18), MPO(11), MTHFR(1), PRDX6(4), SHMT1(1), SHMT2(3), TPO(45)	4532876	99	62	95	55	78	9	1	7	4	0	0.137	1.000	1.000
444	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(5), CASP2(1), CHUK(2), CRADD(1), IKBKB(4), JUN(1), LTA(2), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP3K1(3), MAP3K14(4), MAP4K2(6), MAPK14(5), MAPK8(2), NFKB1(7), NFKBIA(2), RELA(5), RIPK1(1), TNF(1), TNFRSF1A(3), TRAF2(3)	9217209	74	62	74	48	42	12	3	10	7	0	0.871	1.000	1.000
445	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(23), CD28(1), CD3D(5), CD3E(2), CD3G(1), CD8A(2), ICAM1(3), ITGAL(24), ITGB2(14), PTPRC(33), THY1(1)	4117912	109	62	101	48	78	7	2	7	15	0	0.0270	1.000	1.000
446	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(23), CD28(1), CD3D(5), CD3E(2), CD3G(1), CD4(6), ICAM1(3), ITGAL(24), ITGB2(14), PTPRC(33), THY1(1)	4316842	113	62	105	54	80	8	2	8	15	0	0.0599	1.000	1.000
447	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(3), CHRNB1(2), CHRNG(2), MUSK(33), PIK3CA(9), PIK3R1(7), PTK2(8), PTK2B(11), RAPSN(1), SRC(1), TERT(9)	6302245	86	61	82	67	53	7	2	15	8	1	0.959	1.000	1.000
448	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(6), ARHGDIB(3), BIRC2(5), BIRC3(8), CASP1(5), CASP10(5), CASP2(1), CASP3(2), CASP4(1), CASP7(5), CASP8(9), CASP9(3), CYCS(1), DFFA(2), DFFB(3), GZMB(3), LMNA(9), LMNB1(2), LMNB2(4), PRF1(13)	7588306	90	61	88	40	50	12	6	15	7	0	0.352	1.000	1.000
449	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(29), FHL5(13), FSHB(4), FSHR(19), GNAS(22), XPO1(2)	3669903	89	61	85	51	68	6	4	5	6	0	0.644	1.000	1.000
450	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), ELK1(2), EPO(6), EPOR(1), FOS(2), GRB2(2), HRAS(4), JAK2(9), JUN(1), MAP2K1(13), MAPK3(1), MAPK8(2), PLCG1(9), PTPN6(3), RAF1(8), SHC1(3), SOS1(9), STAT5A(3), STAT5B(4)	8261521	83	61	74	41	45	5	7	18	8	0	0.627	1.000	1.000
451	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(3), GRB2(2), HRAS(4), MAPK1(4), MAPK3(1), MAPK7(4), MEF2A(5), MEF2B(3), MEF2C(3), MEF2D(5), NTRK1(19), PIK3CA(9), PIK3R1(7), PLCG1(9), RPS6KA1(9), SHC1(3)	7324520	90	61	86	55	50	13	5	9	12	1	0.808	1.000	1.000
452	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(4), ALG5(2), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT5(3), DDOST(3), DPAGT1(2), DPM1(1), FUT8(8), MAN1A1(17), MAN1B1(4), MGAT1(3), MGAT2(3), MGAT3(10), MGAT4A(8), MGAT4B(1), MGAT5(5), RPN2(2), ST6GAL1(5)	7748008	88	61	86	55	54	10	4	10	10	0	0.702	1.000	1.000
453	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(1), DPM2(1), ELK1(2), FOS(2), GRB2(2), HRAS(4), JUN(1), KLK2(2), MAP2K1(13), MAPK3(1), MAPK8(2), NGFR(8), PIK3CA(9), PIK3R1(7), PLCG1(9), RAF1(8), SHC1(3), SOS1(9)	7376993	84	61	75	37	47	7	4	17	8	1	0.471	1.000	1.000
454	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(4), BIRC2(5), BIRC3(8), CASP3(2), CASP8(9), CFLAR(4), JUN(1), MAP2K4(4), MAP3K3(6), MAP3K7(1), NFKB1(7), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), NR2C2(2), RALBP1(2), RIPK1(1), TNF(1), TNFAIP3(2), TNFRSF1A(3), TNFRSF1B(3), TRAF2(3)	10477390	83	61	82	53	44	6	9	18	6	0	0.939	1.000	1.000
455	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(5), B3GNT1(2), B3GNT2(2), B3GNT3(6), B3GNT4(4), B3GNT5(1), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT4(3), FUT1(3), FUT2(3), FUT3(6), FUT4(2), FUT5(6), FUT6(4), FUT7(2), FUT9(25), ST3GAL6(2), ST8SIA1(1)	6180804	84	60	82	41	54	10	4	7	9	0	0.110	1.000	1.000
456	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(11), POLR1B(9), POLR1C(1), POLR2A(12), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(5), POLR3B(15), POLR3G(1), POLR3GL(1), POLR3H(2), POLR3K(1), ZNRD1(1)	9116270	80	60	79	36	45	8	7	12	8	0	0.310	1.000	1.000
457	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(5), NFKB1(7), NFKBIA(2), PLCB1(52), PRKCA(11), RELA(5)	3179308	82	60	76	30	62	3	3	9	5	0	0.0605	1.000	1.000
458	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(6), CREBBP(23), EP300(14), NCOA3(17), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RARA(3), RXRA(4)	8030342	90	59	90	46	56	5	4	15	10	0	0.764	1.000	1.000
459	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(5), CYSLTR2(4), GPR109B(8), GPR161(7), GPR171(9), GPR18(6), GPR34(2), GPR39(11), GPR45(6), GPR65(10), GPR68(3), GPR75(5), GPR81(5)	3792052	81	59	79	44	58	4	4	6	9	0	0.0147	1.000	1.000
460	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(3), BCL2(2), CASP8(9), CYCS(1), MAP2K1(13), MAP2K4(4), MAP3K1(3), MAPK1(4), MAPK3(1), MAPK8(2), NFKB1(7), NSMAF(4), RAF1(8), RELA(5), RIPK1(1), SMPD1(3), TNFRSF1A(3), TRAF2(3)	7902560	76	58	67	33	45	7	3	13	8	0	0.380	1.000	1.000
461	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(5), CD3E(2), CD3G(1), CD4(6), FYN(7), HLA-DRA(11), HLA-DRB1(4), LCK(14), PTPRC(33), ZAP70(7)	3427242	90	58	85	36	62	8	2	9	9	0	0.0494	1.000	1.000
462	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(3), CASP9(3), CHUK(2), GH1(3), GHR(30), NFKB1(7), NFKBIA(2), PDPK1(4), PIK3CA(9), PIK3R1(7), PPP2CA(1), RELA(5)	5425752	76	57	71	41	48	6	4	9	8	1	0.744	1.000	1.000
463	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), B4GALNT1(3), GLB1(8), HEXA(7), HEXB(4), LCT(43), SLC33A1(5), ST3GAL1(6), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(6), ST6GALNAC4(1), ST6GALNAC5(7), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(9)	6391362	107	57	102	67	77	9	1	14	6	0	0.625	1.000	1.000
464	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(1), ACOT11(9), DHRS1(3), DHRS2(7), DHRS3(4), DHRS7(1), DHRSX(4), ECHS1(2), EHHADH(7), ESCO1(2), ESCO2(3), GCDH(5), HADHA(8), ITGB1BP3(2), MYST3(16), MYST4(16), NAT6(2), PNPLA3(2), SH3GLB1(2), YOD1(1)	10128171	97	57	94	60	56	11	5	19	6	0	0.945	1.000	1.000
465	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(24), CD38(4), ENPP1(13), ENPP3(15), NADSYN1(4), NMNAT2(3), NNMT(9), NNT(3), NT5E(4), NT5M(2), QPRT(6)	5655090	87	57	82	41	54	10	5	9	9	0	0.314	1.000	1.000
466	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(1), APC(22), AXIN1(11), BTRC(5), CTNNB1(13), DLL1(4), FZD1(4), GSK3B(2), NOTCH1(5), PSEN1(1), WNT1(2)	8176380	70	57	70	40	35	7	5	8	15	0	0.840	1.000	1.000
467	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(6), POLD2(2), POLE(16), POLG(9), POLL(7), POLQ(25)	6483926	65	56	64	29	35	5	2	13	10	0	0.338	1.000	1.000
468	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(5), BHMT(9), CBS(7), CTH(1), DNMT1(19), DNMT3A(6), DNMT3B(10), MARS(6), MARS2(4), MAT1A(5), MAT2B(3), MTR(10)	6845986	85	56	82	31	54	4	7	12	8	0	0.0296	1.000	1.000
469	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(23), EP300(14), LPL(3), NCOA1(10), NCOA2(13), PPARG(11), RXRA(4)	7215398	78	56	76	31	52	4	3	12	7	0	0.406	1.000	1.000
470	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(5), GNAQ(5), HTR2C(12), PLCB1(52), TUB(9)	2771390	83	56	77	42	65	2	2	9	5	0	0.211	1.000	1.000
471	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(2), GCK(20), GFPT1(4), GNE(3), GNPDA2(1), HEXA(7), HEXB(4), HK1(3), HK2(12), HK3(15), PGM3(4), RENBP(3), UAP1(2)	6582743	80	55	77	44	53	7	3	9	8	0	0.464	1.000	1.000
472	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(21), ACACB(21), FASN(17), MCAT(2), OLAH(13), OXSM(2)	6119869	76	55	75	42	48	7	3	9	9	0	0.335	1.000	1.000
473	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(7), ACOX3(13), FADS2(4), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(7), PLA2G3(18), PLA2G4A(11), PLA2G5(3), PLA2G6(11)	3929120	88	55	85	48	64	5	1	7	11	0	0.264	1.000	1.000
474	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(7), ARG1(2), ARG2(1), ASL(6), CKM(2), CKMT1A(1), CKMT2(5), CPS1(22), GAMT(4), GATM(5), GLUD1(2), NAGS(1), OAT(3), ODC1(3), OTC(3), PYCR1(2), SMS(6)	6703986	77	55	75	33	44	9	4	10	10	0	0.149	1.000	1.000
475	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(5), CHUK(2), IFNG(2), IKBKB(4), IL2(4), IL4(1), JUN(1), MAP3K1(3), MAP3K5(18), MAP4K5(3), MAPK14(5), MAPK8(2), NFKB1(7), NFKBIA(2), RELA(5), TNFRSF9(4), TNFSF9(1), TRAF2(3)	7429779	72	54	69	36	44	6	1	12	9	0	0.622	1.000	1.000
476	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF2(2), CSF3(5), EPO(6), FLT3(31), IGF1(11), IL11(2), IL1A(4), IL3(3), IL6(2), IL9(1), KITLG(9), TGFB1(1), TGFB2(1), TGFB3(3)	3196428	81	54	74	35	54	7	4	10	6	0	0.0561	1.000	1.000
477	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(12), CYP11A1(15), CYP11B2(14), CYP17A1(7), HSD11B1(11), HSD11B2(2), HSD3B1(10), HSD3B2(11)	2675129	82	54	78	56	60	7	1	6	8	0	0.156	1.000	1.000
478	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(7), ASPH(3), COPS5(3), EDN1(9), EP300(14), EPO(6), HIF1A(5), JUN(1), LDHA(6), NOS3(17), P4HB(3), VHL(4)	6632912	78	54	75	35	48	4	5	10	11	0	0.533	1.000	1.000
479	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(42), CYP2C9(38)	783781	80	54	72	51	64	4	2	4	6	0	0.615	1.000	1.000
480	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(8), IL22(2), IL22RA1(12), IL22RA2(1), JAK1(6), JAK2(9), JAK3(7), SOCS3(2), STAT1(4), STAT3(11), STAT5A(3), STAT5B(4), TYK2(8)	7060911	77	54	77	44	39	8	7	16	7	0	0.721	1.000	1.000
481	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(6), CSF1(11), CSF2(2), CSF3(5), HLA-DRA(11), HLA-DRB1(4), IFNA1(1), IFNB1(6), IFNG(2), IL10(3), IL11(2), IL12A(3), IL12B(4), IL13(2), IL15(3), IL1A(4), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(5), IL8(1), LTA(2), PDGFA(1), TGFB1(1), TGFB2(1), TGFB3(3), TNF(1)	5099791	98	54	96	53	67	7	3	9	12	0	0.0637	1.000	1.000
482	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(4), ACADM(6), ACADS(4), ACADVL(1), ACSL1(6), ACSL3(6), ACSL4(2), CPT1A(11), CPT2(1), DCI(2), EHHADH(7), HADHA(8), PECR(1), SCP2(4), SLC25A20(1)	6587851	64	54	61	31	42	4	3	9	6	0	0.580	1.000	1.000
483	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(3), IL6(2), IL6R(4), JAK1(6), JAK2(9), JAK3(7), PIAS3(5), PTPRU(16), REG1A(8), SRC(1), STAT3(11)	5887613	72	54	72	41	39	7	3	12	11	0	0.577	1.000	1.000
484	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(3), DPM2(1), GRB2(2), HRAS(4), KLK2(2), NTRK1(19), PIK3CA(9), PIK3R1(7), PLCG1(9), PRKCA(11), SHC1(3), SOS1(9)	6031555	79	54	77	36	44	10	4	12	8	1	0.455	1.000	1.000
485	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(4), ARFGAP3(3), ARFGEF2(19), CLTA(1), CLTB(1), COPA(7), GBF1(12), GPLD1(24), KDELR3(2)	6360760	73	53	73	46	42	5	5	14	7	0	0.863	1.000	1.000
486	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CALM2(1), CAMK1(5), CAMK1G(11), CAMK2A(4), CAMK2B(7), CAMK2D(6), CAMK2G(5), CAMK4(12), CAMKK1(3), CAMKK2(8), SYT1(20)	4506424	83	53	77	65	61	8	2	8	4	0	0.917	1.000	1.000
487	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CALM2(1), CCL2(1), CCR5(7), CXCL12(2), CXCR4(4), FOS(2), GNAQ(5), JUN(1), MAPK14(5), MAPK8(2), PLCG1(9), PRKCA(11), PTK2B(11), SYT1(20)	5365723	82	53	77	59	54	7	4	12	5	0	0.854	1.000	1.000
488	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(7), B3GAT2(2), B3GAT3(4), CHPF(4), CHST11(5), CHST12(4), CHST13(3), CHST14(3), CHST3(1), CHSY1(8), DSE(19), XYLT1(13), XYLT2(3)	5142169	76	53	76	50	50	11	3	8	4	0	0.457	1.000	1.000
489	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(6), ACOX1(7), ACOX3(13), ELOVL2(2), ELOVL5(1), ELOVL6(2), FADS2(4), FASN(17), HADHA(8), HSD17B12(2), PECR(1), SCD(3)	5535921	66	53	65	32	43	4	3	9	7	0	0.0977	1.000	1.000
490	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(6), DHRS1(3), DHRS2(7), DHRS3(4), DHRS7(1), DHRSX(4), HEMK1(5), LCMT1(4), METTL2B(8), METTL6(3), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), WBSCR22(1)	5849756	70	52	69	34	41	9	2	14	4	0	0.308	1.000	1.000
491	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(20), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C2(9), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), FDXR(8), SHMT1(1)	6225829	80	51	79	45	44	5	6	14	11	0	0.510	1.000	1.000
492	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(7), F13B(24), HSD17B2(10), HSD17B3(6), HSD17B4(6), HSD17B7(2), HSD3B1(10), HSD3B2(11)	3107701	76	51	70	32	54	5	5	4	7	1	0.0547	1.000	1.000
493	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(20), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C2(9), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), SHMT1(1)	5852197	72	50	71	41	39	4	6	13	10	0	0.570	1.000	1.000
494	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(20), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C2(9), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), SHMT1(1)	5852197	72	50	71	41	39	4	6	13	10	0	0.570	1.000	1.000
495	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH9A1(3), ECHS1(2), EHHADH(7), HADHA(8), SDS(2)	4703326	63	50	61	34	36	10	2	9	6	0	0.351	1.000	1.000
496	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(3), JAK1(6), JAK2(9), JAK3(7), PIAS1(5), PIAS3(5), PTPRU(16), REG1A(8), SOAT1(3)	5296375	62	50	62	29	38	5	2	8	9	0	0.294	1.000	1.000
497	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(20), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C2(9), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), SHMT1(1)	5852197	72	50	71	41	39	4	6	13	10	0	0.570	1.000	1.000
498	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(31), MAP2(13), PPP1CA(2), PPP2CA(1), PRKACB(4), PRKACG(8), PRKAG1(2), PRKAR2A(1), PRKAR2B(5), PRKCE(6)	7020342	73	49	71	44	44	7	5	8	9	0	0.939	1.000	1.000
499	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(6), CD3D(5), CD3E(2), CD3G(1), GZMB(3), HLA-A(3), ICAM1(3), ITGAL(24), ITGB2(14), PRF1(13)	3370721	74	49	73	31	45	7	1	6	15	0	0.0368	1.000	1.000
500	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(19), EGFR(23), ERBB3(6), NRG1(17), UBE2D1(1)	4011460	66	49	65	41	48	2	5	7	4	0	0.931	1.000	1.000
501	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(6), B3GALNT1(6), B3GALT5(1), FUT1(3), FUT2(3), FUT9(25), GBGT1(2), GLA(1), HEXA(7), HEXB(4), NAGA(4), ST3GAL1(6), ST3GAL2(1), ST8SIA1(1)	4165929	70	49	68	40	47	6	4	9	4	0	0.388	1.000	1.000
502	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(11), CD4(6), HLA-DRA(11), HLA-DRB1(4), IL1B(7), IL4(1), IL5(4), IL5RA(14), IL6(2)	2071557	61	49	58	34	46	2	1	5	7	0	0.149	1.000	1.000
503	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(5), CAMK1G(11), HDAC9(44), MEF2A(5), MEF2B(3), MEF2C(3), MEF2D(5), MYOD1(1)	2878500	77	49	67	33	60	6	0	4	7	0	0.119	1.000	1.000
504	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(2), CREBBP(23), EP300(14), HDAC3(6), IKBKB(4), NFKB1(7), NFKBIA(2), RELA(5), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF6(5)	8647792	76	49	76	38	45	7	5	13	6	0	0.654	1.000	1.000
505	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(2), MAP3K14(4), MAPK14(5), MAPK8(2), NFKB1(7), RELA(5), TNFRSF13B(8), TNFRSF17(6), TNFSF13B(1), TRAF2(3), TRAF3(5), TRAF5(7), TRAF6(5)	5574975	60	49	59	26	39	7	0	11	3	0	0.289	1.000	1.000
506	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(4), EGF(19), EGFR(23), HGS(4), RAB5A(1), TF(13), TFRC(5)	4980830	69	48	69	43	45	2	7	9	6	0	0.908	1.000	1.000
507	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), KHK(1), LCT(43), MPI(1), PGM1(4), PYGL(9), PYGM(10), TREH(3)	5119104	74	48	70	61	58	6	1	5	4	0	0.832	1.000	1.000
508	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GALNS(4), GLB1(8), GNS(2), GUSB(4), HEXA(7), HEXB(4), IDS(9), IDUA(4), LCT(43), NAGLU(4)	5544383	90	48	85	50	72	5	0	8	5	0	0.415	1.000	1.000
509	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), CYP51A1(1), DHCR24(1), DHCR7(10), FDPS(3), GGCX(4), GGPS1(1), HMGCR(18), HSD17B7(2), IDI1(1), IDI2(1), LSS(2), MVD(1), MVK(3), NQO1(1), NSDHL(3), PMVK(2), SC4MOL(3), SC5DL(2), SQLE(5), TM7SF2(5)	7475888	70	48	63	31	33	11	4	14	8	0	0.237	1.000	1.000
510	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(1), MRPS7(2), RPL10L(6), RPL11(2), RPL13A(2), RPL14(1), RPL18(3), RPL18A(1), RPL19(1), RPL21(1), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL36AL(1), RPL38(1), RPL39(1), RPL3L(3), RPL6(1), RPL7(2), RPS10(1), RPS11(1), RPS13(1), RPS16(1), RPS18(1), RPS2(2), RPS20(2), RPS23(1), RPS24(1), RPS27(1), RPS29(1), RPS3A(1), RPS4Y1(1), RPS5(2), RPS6(1), RPS7(4), RPS8(1), RPSA(2)	8738644	65	48	65	44	34	6	8	10	7	0	0.871	1.000	1.000
511	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(6), CLOCK(5), CRY1(7), CRY2(3), CSNK1D(1), CSNK1E(4), NPAS2(7), PER1(8), PER2(13), PER3(9)	6600024	63	48	60	43	40	7	2	4	10	0	0.937	1.000	1.000
512	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(13), CDC25A(8), CDC25B(6), CDC25C(5), CHEK1(2), MYT1(22), WEE1(3)	5347172	59	47	57	31	35	6	2	8	8	0	0.803	1.000	1.000
513	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(14), AMT(2), ATIC(5), FTCD(3), GART(10), MTFMT(2), MTHFD1(10), MTHFD1L(1), MTHFD2(2), MTHFR(1), MTR(10), SHMT1(1), SHMT2(3), TYMS(1)	7355030	65	47	64	41	41	7	3	7	7	0	0.819	1.000	1.000
514	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(5), APAF1(6), BCL2(2), CASP3(2), CASP9(3), CYCS(1), DAXX(10), FAS(5), FASLG(14), HSPB1(2), HSPB2(1), IL1A(4), MAPKAPK2(5), MAPKAPK3(4), TNF(1)	4417720	65	47	65	31	42	4	3	8	8	0	0.271	1.000	1.000
515	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(8), IL13(2), IL4(1), IL5(4), MAF(1), MAP2K3(9), MAPK14(5), NFATC1(15), NFATC2(9), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5)	4675585	77	46	75	48	51	8	4	5	9	0	0.595	1.000	1.000
516	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(6), CHPT1(1), HEMK1(5), LCMT1(4), METTL2B(8), METTL6(3), PCYT1A(3), PCYT1B(8), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), WBSCR22(1)	5451276	63	46	61	25	37	7	4	11	4	0	0.119	1.000	1.000
517	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(2), B3GNT2(2), B3GNT7(4), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT4(3), CHST1(9), CHST2(4), CHST4(11), CHST6(4), FUT8(8), ST3GAL1(6), ST3GAL2(1), ST3GAL3(2), ST3GAL4(1)	4823741	64	46	62	45	42	12	4	2	4	0	0.624	1.000	1.000
518	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(6), ARHGAP5(12), ARHGDIB(3), CASP1(5), CASP10(5), CASP3(2), CASP8(9), CASP9(3), CYCS(1), GZMB(3), JUN(1), PRF1(13)	5019978	63	45	60	32	41	6	3	9	4	0	0.666	1.000	1.000
519	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(6), FUT1(3), FUT2(3), FUT9(25), GBGT1(2), GLA(1), HEXA(7), HEXB(4), NAGA(4), ST3GAL1(6), ST3GAL2(1), ST3GAL4(1), ST8SIA1(1)	3922314	64	45	62	30	43	6	2	9	4	0	0.121	1.000	1.000
520	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNB1(6), JAK1(6), PTPRU(16), REG1A(8), STAT1(4), STAT2(8), TYK2(8)	4863039	58	45	58	31	30	5	2	10	11	0	0.461	1.000	1.000
521	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(14), AMT(2), ATIC(5), GART(10), MTHFD1(10), MTHFD1L(1), MTHFD2(2), MTHFR(1), MTR(10), SHMT1(1), SHMT2(3), TYMS(1)	6946441	60	44	59	36	37	7	3	7	6	0	0.724	1.000	1.000
522	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(3), GNAS(22), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(11)	3670577	59	43	57	41	46	4	2	2	5	0	0.934	1.000	1.000
523	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(20), AOC2(8), AOC3(8), CES1(16), ESD(2)	2334551	54	43	52	36	43	2	4	2	3	0	0.616	1.000	1.000
524	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(20), HK1(3), HK2(12), HK3(15), IMPA1(2), IMPA2(2), ISYNA1(2), PGM1(4), PGM3(4), TGDS(1)	4517807	65	43	63	41	44	7	1	6	7	0	0.525	1.000	1.000
525	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(23), EP300(14), ESR1(5), MAPK1(4), MAPK3(1), PELP1(12), SRC(1)	5690711	60	43	60	30	40	3	3	10	4	0	0.632	1.000	1.000
526	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(2), IKBKAP(5), IKBKB(4), LTA(2), MAP3K1(3), MAP3K14(4), NFKB1(7), NFKBIA(2), RELA(5), RIPK1(1), TNFAIP3(2), TNFRSF1B(3), TRAF1(6), TRAF2(3), TRAF3(5)	8647884	54	43	54	48	34	8	1	6	5	0	0.997	1.000	1.000
527	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(5), FARSA(6), FARSB(5), GOT1(6), GOT2(7), PAH(9), TAT(17), YARS(1), YARS2(2)	3384610	58	42	55	26	42	6	2	3	5	0	0.107	1.000	1.000
528	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(5), ACO2(5), AFMID(3), CS(2), GRHPR(2), HAO1(8), HAO2(14), HYI(1), MDH1(1), MDH2(4), MTHFD1(10), MTHFD1L(1), MTHFD2(2)	5202281	58	42	54	30	34	5	4	6	9	0	0.335	1.000	1.000
529	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(5), CHST12(4), CHST13(3), PAPSS1(3), PAPSS2(5), SULT1A1(12), SULT1A2(4), SULT1E1(16), SULT2A1(8), SULT2B1(7), SUOX(5)	3535704	72	42	69	39	58	4	0	4	6	0	0.264	1.000	1.000
530	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(3), ECHS1(2), EHHADH(7), HADHA(8), HSD17B10(2), HSD17B4(6), NTAN1(1), SIRT2(1), SIRT5(7), SIRT7(2), VNN2(14)	4600029	53	42	51	17	34	5	3	9	2	0	0.0755	1.000	1.000
531	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(7), ANKRD1(1), CYR61(1), DUSP14(2), EIF4E(1), EIF4EBP1(1), HBEGF(1), IFNG(2), IFRD1(2), IL18(2), IL1A(4), IL1R1(12), JUND(1), MYOG(3), NR4A3(7), WDR1(5)	4123537	52	42	50	25	34	5	2	4	7	0	0.467	1.000	1.000
532	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(3), BLVRB(1), HMOX1(1), IL10(3), IL10RA(8), IL10RB(5), IL1A(4), IL6(2), JAK1(6), STAT1(4), STAT3(11), STAT5A(3), TNF(1)	4740570	52	42	51	26	24	5	6	9	8	0	0.367	1.000	1.000
533	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(23), CD34(4), CD3D(5), CD3E(2), CD3G(1), CD4(6), CD58(1), CD8A(2), CSF3(5), IL3(3), IL6(2), IL8(1), KITLG(9)	2382499	64	42	58	30	47	4	2	7	4	0	0.111	1.000	1.000
534	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(2), IL2RG(3), IL4(1), IL4R(14), IRS1(6), JAK1(6), JAK3(7), RPS6KB1(2), SHC1(3), STAT6(8)	5721321	55	42	55	26	31	7	4	5	8	0	0.331	1.000	1.000
535	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(5), CBS(7), CTH(1), GGT1(7), MARS(6), MARS2(4), MAT1A(5), MAT2B(3), PAPSS1(3), PAPSS2(5), SCLY(3), SEPHS1(4)	4842927	53	42	52	24	33	4	3	8	5	0	0.170	1.000	1.000
536	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(6), CHAT(15), CHKA(2), PCYT1A(3), PDHA1(3), PDHA2(19), PEMT(2), SLC18A3(3)	2661585	53	41	49	26	43	5	0	2	3	0	0.119	1.000	1.000
537	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(1), DHCR7(10), FDPS(3), HMGCR(18), HMGCS1(2), IDI1(1), LSS(2), MVD(1), MVK(3), NSDHL(3), PMVK(2), SC4MOL(3), SC5DL(2), SQLE(5)	5107804	56	41	49	22	25	8	2	14	7	0	0.268	1.000	1.000
538	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(6), IFNG(2), IL10(3), IL12A(3), IL12B(4), IL13(2), IL15(3), IL16(13), IL18(2), IL1A(4), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL8(1), IL9(1), LTA(2), TNF(1)	3833389	62	41	61	35	43	3	3	4	9	0	0.215	1.000	1.000
539	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(2), JUN(1), MAPK3(1), OPRK1(23), POLR2A(12), PRKACB(4), PRKACG(8), PRKAR1A(2), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5)	4979606	62	41	60	56	48	3	3	3	5	0	0.985	1.000	1.000
540	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(7), CDKN1A(4), EPO(6), EPOR(1), GRIN1(7), HIF1A(5), JAK2(9), NFKB1(7), NFKBIA(2), RELA(5)	4863099	53	41	52	27	23	5	5	10	10	0	0.750	1.000	1.000
541	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(29), GNAS(22), PRKACA(4), PRKAR1A(2)	2519614	57	41	54	27	38	5	3	5	6	0	0.244	1.000	1.000
542	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(2), BET1L(1), BNIP1(2), GOSR1(1), SEC22B(5), SNAP25(6), SNAP29(1), STX10(1), STX11(2), STX12(1), STX16(2), STX17(2), STX19(2), STX2(4), STX3(2), STX5(4), STX6(2), TSNARE1(4), VAMP1(1), VAMP3(1), VAMP4(1), VAMP7(5), VAMP8(1), VTI1A(1), VTI1B(1)	6425306	55	41	52	31	31	6	2	9	7	0	0.636	1.000	1.000
543	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(6), BAX(3), BCL2(2), BIK(2), BIRC2(5), BIRC3(8), CASP3(2), CASP7(5), CASP8(9), CASP9(3), CYCS(1), DFFA(2), DFFB(3), DIABLO(1)	5239828	52	41	51	16	29	5	6	7	5	0	0.129	1.000	1.000
544	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(2), FOSL2(6), IFNAR1(2), IFNAR2(7), IFNB1(6), MAPK8(2), NFKB1(7), RELA(5), TNFRSF11A(5), TNFSF11(4), TRAF6(5)	4296255	51	41	50	27	34	3	0	9	5	0	0.688	1.000	1.000
545	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(16), MBTPS1(9), MBTPS2(1), SCAP(8), SREBF1(5), SREBF2(10)	4601855	51	41	48	27	32	2	3	9	5	0	0.485	1.000	1.000
546	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(20), HK1(3), HK2(12), HK3(15), IMPA1(2), PGM1(4), PGM3(4), TGDS(1)	3970972	61	41	59	36	43	7	1	5	5	0	0.439	1.000	1.000
547	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(12), CYP2E1(13), NR1I3(7), PTGS1(17), PTGS2(11)	2092624	60	40	58	35	45	4	1	4	6	0	0.283	1.000	1.000
548	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(4), HS3ST1(11), HS3ST2(8), HS3ST3A1(4), HS3ST3B1(2), XYLT1(13), XYLT2(3)	2465347	45	40	45	39	29	6	1	5	4	0	0.844	1.000	1.000
549	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(5), ACO2(5), CS(2), GRHPR(2), HAO1(8), HAO2(14), HYI(1), MDH1(1), MDH2(4), MTHFD1(10), MTHFD1L(1), MTHFD2(2)	4966890	55	40	51	26	32	5	3	6	9	0	0.240	1.000	1.000
550	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(4), HS3ST1(11), HS3ST2(8), HS3ST3A1(4), HS3ST3B1(2), XYLT1(13), XYLT2(3)	2465347	45	40	45	39	29	6	1	5	4	0	0.844	1.000	1.000
551	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(8), DHRS1(3), DHRS2(7), DHRS3(4), DHRS7(1), DHRSX(4), HSD3B7(3), PON1(15), PON2(1), PON3(6), RDH11(2), RDH12(2), RDH13(3)	3509834	59	40	56	32	41	4	2	7	5	0	0.301	1.000	1.000
552	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(2), IKBKAP(5), IKBKB(4), MAP3K1(3), MAP3K14(4), NFKB1(7), NFKBIA(2), RELA(5), TNFAIP3(2), TRAF3(5), TRAF6(5)	7001774	44	39	44	34	26	8	1	6	3	0	0.979	1.000	1.000
553	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(3), DHRS2(7), DHRS3(4), DHRS7(1), DHRSX(4), ESCO1(2), ESCO2(3), MYST3(16), MYST4(16), NAT6(2), PNPLA3(2), SH3GLB1(2)	6465989	62	38	61	44	35	7	3	13	4	0	0.991	1.000	1.000
554	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(3), IFNG(2), IFNGR1(4), JAK1(6), JAK2(9), PLA2G2A(2), PTPRU(16), REG1A(8), STAT1(4)	4432488	54	38	54	23	31	2	1	9	11	0	0.326	1.000	1.000
555	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(6), CD8A(2), CSF1(11), CSF2(2), CSF3(5), EPO(6), IL11(2), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(5), IL8(1), IL9(1)	2346141	55	38	52	32	40	4	1	4	6	0	0.178	1.000	1.000
556	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(2), CD36(4), FOS(2), FYN(7), JUN(1), MAPK14(5), THBS1(30)	2875021	51	38	50	28	31	1	2	7	10	0	0.701	1.000	1.000
557	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(9), POLR2A(12), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(2)	5190884	44	37	43	18	26	4	3	6	5	0	0.188	1.000	1.000
558	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(18), CKM(2), EIF4E(1), FBL(1), GPT(3), LDHA(6), LDHB(2), LDHC(5), MAPK14(5), NCL(6)	3487077	49	37	48	23	33	2	5	5	4	0	0.354	1.000	1.000
559	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(3), IL13RA2(3), IL4R(14), JAK1(6), JAK2(9), TYK2(8)	4059082	45	37	45	23	27	3	2	8	5	0	0.660	1.000	1.000
560	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(3), IL13RA2(3), IL4R(14), JAK1(6), JAK2(9), TYK2(8)	4059082	45	37	45	23	27	3	2	8	5	0	0.660	1.000	1.000
561	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH9A1(3)	3085071	44	35	43	27	24	8	2	5	5	0	0.529	1.000	1.000
562	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(5), ALDH1A2(12), ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH9A1(3)	3085071	44	35	43	27	24	8	2	5	5	0	0.529	1.000	1.000
563	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(10), FDPS(3), HMGCR(18), IDI1(1), LSS(2), MVD(1), MVK(3), NQO1(1), PMVK(2), SC5DL(2), SQLE(5)	4273867	48	35	41	20	20	6	2	14	6	0	0.359	1.000	1.000
564	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(9), ALPL(9), ALPP(11), ALPPL2(12), FPGS(3), GGH(2), SPR(2)	2471391	48	35	45	26	37	6	2	1	2	0	0.139	1.000	1.000
565	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(10), ACO1(5), ACO2(5), ACSS1(1), ACSS2(4), FH(3), IDH1(15), IDH2(2), MDH1(1), MDH2(4)	5192961	50	35	37	25	34	1	2	9	4	0	0.300	1.000	1.000
566	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(11), CAPN1(4), CAPNS1(1), CDK5(4), CSNK1A1(3), CSNK1D(1), GSK3B(2), MAPT(12), PPP2CA(1)	3493818	39	35	38	20	25	2	3	4	5	0	0.469	1.000	1.000
567	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(19), EIF2AK4(14), EIF2B5(1), EIF2S1(1), EIF5(2), GSK3B(2), PPP1CA(2)	4518473	41	33	37	15	18	1	2	13	7	0	0.623	1.000	1.000
568	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(9), ALDH2(4), ALDH3A1(7), ALDH3A2(2), ALDH7A1(10), ALDH9A1(3), MIOX(3), UGDH(1)	3285044	41	33	39	27	22	8	4	4	3	0	0.676	1.000	1.000
569	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(20), GNA12(3), PRKACB(4), PRKACG(8), PRKAG1(2), PRKAR2A(1), PRKAR2B(5)	3916348	43	32	43	27	30	4	1	5	3	0	0.790	1.000	1.000
570	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(5), PSMA2(1), PSMA4(2), PSMA5(4), PSMA6(4), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC2(2), PSMC3(4), PSMD1(5), PSMD12(1), PSMD13(3), PSMD2(3)	6267280	41	32	40	19	23	4	2	8	4	0	0.625	1.000	1.000
571	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(2), IFNAR2(7), IFNB1(6), JAK1(6), STAT1(4), STAT2(8), TYK2(8)	4184403	42	32	42	22	21	4	2	9	6	0	0.616	1.000	1.000
572	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(6), JAK2(9), JAK3(7), MAPK1(4), MAPK3(1), STAT3(11), TYK2(8)	4514037	46	32	46	32	21	7	3	8	7	0	0.907	1.000	1.000
573	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(6), ADORA2A(2), ADORA2B(3), ADORA3(12), LTB4R(1), P2RY1(4), P2RY2(8), P2RY6(1)	2312357	37	31	37	31	24	5	0	5	3	0	0.367	1.000	1.000
574	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(8), CDC25B(6), CDC25C(5), CSK(1), GRB2(2), PRKCA(11), PTPRA(7), SRC(1)	3608410	41	31	40	27	25	7	1	5	3	0	0.818	1.000	1.000
575	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(4), NRF1(4), UBE2D1(1), UBE2D3(3), UBE2E1(1), UBE2E3(1), UBE2G2(1), UBE2H(1), UBE2I(3), UBE2J1(2), UBE2J2(6), UBE2L6(2), UBE2M(1), UBE2S(2), UBE3A(7)	4108473	39	31	38	19	26	5	1	5	2	0	0.626	1.000	1.000
576	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(13), ENO1(4), GPI(3), HK1(3), PFKL(4), PGK1(5), PKLR(11)	3560526	43	30	40	19	29	4	1	5	4	0	0.0513	1.000	1.000
577	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(4), BIRC3(8), CASP8(9), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF2(3)	3182250	32	30	31	13	23	1	2	3	3	0	0.244	1.000	1.000
578	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3D(5), CD3E(2), CD3G(1), IFNG(2), IL2(4), IL2RA(4), IL4(1), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(7), TGFBR3(6), TOB1(3), TOB2(2)	4087982	43	30	43	27	33	2	0	1	7	0	0.643	1.000	1.000
579	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(6), ACAA2(2), ACAT2(1), ECHS1(2), EHHADH(7), HADHA(8), HADHB(4), SDS(2)	3247830	32	29	31	14	20	3	2	4	3	0	0.398	1.000	1.000
580	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(3), GBA(5), GBA3(14), GGT1(7), SHMT1(1), SHMT2(3)	2082062	33	29	31	17	24	2	0	4	3	0	0.259	1.000	1.000
581	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(2), CTSD(3), ESR1(5), GREB1(18), HSPB1(2), HSPB2(1), MTA1(2), MTA3(3), PDZK1(3), TUBA8(3)	4139828	42	29	41	28	31	2	3	4	2	0	0.614	1.000	1.000
582	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(5), PSMA2(1), PSMA4(2), PSMA5(4), PSMA6(4), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC3(4), PSMD14(1), RPN2(2), UBE3A(7)	5044703	37	29	37	20	20	4	1	8	4	0	0.807	1.000	1.000
583	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(6), CPS1(22), GLS(2), GLUD1(2), GOT1(6)	2970287	40	29	38	17	25	4	2	7	2	0	0.313	1.000	1.000
584	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(6), CD80(5), HLA-DRA(11), HLA-DRB1(4), IL10(3), IL2(4), IL4(1)	1530275	35	28	35	21	23	1	1	6	4	0	0.408	1.000	1.000
585	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(5), B3GALT1(12), B3GALT2(1), B3GALT5(1), B3GNT5(1), FUT1(3), FUT2(3), FUT3(6), ST3GAL3(2), ST3GAL4(1)	2781181	35	28	34	28	26	3	0	4	2	0	0.835	1.000	1.000
586	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(7), ADSS(2), IMPDH1(2), MTHFD2(2), POLD1(6), POLG(9), PRPS2(4), RRM1(3)	4820434	35	28	35	26	19	3	1	5	7	0	0.946	1.000	1.000
587	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	FOS(2), JUN(1), KEAP1(2), MAFG(1), MAFK(1), MAPK1(4), MAPK14(5), MAPK8(2), NFE2L2(4), PRKCA(11)	3431224	33	27	32	15	22	2	0	4	5	0	0.403	1.000	1.000
588	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(6), CLOCK(5), CRY1(7), CRY2(3), CSNK1E(4), PER1(8)	3279256	33	27	32	17	19	3	2	3	6	0	0.722	1.000	1.000
589	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(2), CASP7(5), DFFA(2), DFFB(3), GZMB(3), HMGB1(1), HMGB2(1), TOP2A(10), TOP2B(8)	3473938	35	27	35	12	23	1	4	5	2	0	0.356	1.000	1.000
590	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(8), PLCG1(9), PRKCA(11), PTK2B(11)	2623613	39	27	38	29	29	4	1	2	3	0	0.642	1.000	1.000
591	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP2(24), RANGAP1(3)	3307782	29	27	29	12	19	2	1	3	4	0	0.616	1.000	1.000
592	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(2), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT5(3), FUT8(8), ST3GAL1(6), ST3GAL2(1), ST3GAL3(2), ST3GAL4(1)	3046319	30	26	29	19	16	6	3	2	3	0	0.710	1.000	1.000
593	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(2), CDC25A(8), CDC25B(6), CDC25C(5), MNAT1(2), SHH(5), XPO1(2)	3391180	30	26	30	14	15	5	2	6	2	0	0.673	1.000	1.000
594	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(2), HBXIP(1), HRAS(4), PTK2B(11), SHC1(3), SOS1(9), SRC(1)	3418083	31	25	31	22	20	3	1	5	2	0	0.942	1.000	1.000
595	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1), BDH1(5), HMGCL(4), HMGCS1(2), HMGCS2(18), OXCT1(5), OXCT2(4)	2775498	39	25	38	23	25	5	0	6	3	0	0.754	1.000	1.000
596	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	11	ALAD(5), ALAS1(1), ALAS2(5), CPO(2), FECH(3), GATA1(3), HBB(6), HMBS(2), UROS(1)	2966192	28	24	27	19	21	2	0	1	4	0	0.673	1.000	1.000
597	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(14), GGT1(7), SHMT1(1), SHMT2(3)	1577501	25	24	23	16	18	2	0	3	2	0	0.444	1.000	1.000
598	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), CSF1(11), IL1B(7), MST1(2), MST1R(8), TNF(1)	2541526	30	24	29	22	23	2	1	0	4	0	0.800	1.000	1.000
599	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(5), FUT1(3), FUT2(3), FUT3(6), FUT5(6), FUT6(4), ST3GAL3(2)	1937625	29	23	29	19	17	3	1	3	5	0	0.418	1.000	1.000
600	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(5), APOBEC1(6), APOBEC2(4), APOBEC3A(2), APOBEC3B(2), APOBEC3C(2), APOBEC3F(4), APOBEC3G(2)	2871510	27	23	27	28	21	2	3	1	0	0	0.987	1.000	1.000
601	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(5), CS(2), FH(3), IDH2(2), MDH1(1), OGDH(11), SDHA(3)	3679477	27	23	26	21	17	1	2	3	4	0	0.912	1.000	1.000
602	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(24), PNPO(1), PSAT1(2)	1889662	27	22	25	19	23	1	1	2	0	0	0.804	1.000	1.000
603	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(5), ALAS1(1), ALAS2(5), CPOX(4), FECH(3), HMBS(2), PPOX(3), UROS(1)	2939301	24	21	24	10	16	2	1	2	3	0	0.290	1.000	1.000
604	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(6), HLA-DRA(11), HLA-DRB1(4)	913436	22	20	22	15	17	1	0	3	1	0	0.559	1.000	1.000
605	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ3(4), COQ5(3), COQ6(2), COQ7(2), NDUFA12(1), NDUFA13(7)	1546546	20	20	18	12	14	1	3	1	1	0	0.764	1.000	1.000
606	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(8), EPHX2(4), HSD3B7(3), RDH11(2), RDH12(2), RDH13(3)	1871393	22	19	22	19	15	1	2	1	3	0	0.854	1.000	1.000
607	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(4), IFNGR2(4), JAK1(6), JAK2(9), STAT1(4)	3171955	29	19	27	10	11	1	1	7	9	0	0.687	1.000	1.000
608	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(5), BMPR1A(2), BMPR1B(4), BMPR2(6)	2440597	17	17	17	11	7	3	0	3	4	0	0.839	1.000	1.000
609	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(6), ST3GAL2(1), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(2), ST6GALNAC4(1), ST8SIA1(1)	2203596	16	16	16	12	11	2	1	2	0	0	0.725	1.000	1.000
610	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(7), CD28(1), CD3D(5), CD3E(2), CD3G(1), CD4(6)	1244752	22	16	22	24	15	3	0	3	1	0	0.959	1.000	1.000
611	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(1), DLL1(4), FURIN(5), NOTCH1(5), PSEN1(1)	3566145	16	15	16	18	9	3	1	3	0	0	0.973	1.000	1.000
612	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(4), HGD(12)	873451	16	14	16	17	12	2	2	0	0	0	0.958	1.000	1.000
613	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(6), ARG1(2), GLS(2), GLUD1(2), OAT(3), PRODH(1)	2114541	16	12	16	13	6	5	2	2	1	0	0.928	1.000	1.000
614	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(17)	709023	19	12	18	11	14	2	1	2	0	0	0.580	1.000	1.000
615	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(2), TGDS(1), UGDH(1), UGP2(2), UXS1(4)	1914223	11	11	11	10	5	0	1	0	5	0	0.963	1.000	1.000
616	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(4)	825779	4	4	4	5	3	0	0	1	0	0	0.943	1.000	1.000
