rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(2), MMP14(2), MMP2(3), MMP9(4), RECK(2), TIMP1(1), TIMP3(1), TIMP4(2)	340497	17	15	17	2	10	2	1	4	0	0	0.0189	0.0378	1.000
2	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(4)	32727	4	4	4	0	3	1	0	0	0	0	0.131	0.0389	1.000
3	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(2), DCN(6), FMOD(2), KERA(8), LUM(4)	161484	22	15	22	5	16	2	3	1	0	0	0.0163	0.0446	1.000
4	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(3), SNAP25(2), STX1A(1)	149636	8	7	8	1	3	1	0	1	3	0	0.0893	0.154	1.000
5	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(2), GRIA2(5), PPP1R1B(1)	168715	8	8	7	1	6	0	0	0	2	0	0.114	0.221	1.000
6	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CDC34(1), CUL1(2), E2F1(2), FBXW7(4), RB1(2), TFDP1(1)	373766	13	10	13	2	5	1	2	1	3	1	0.0712	0.269	1.000
7	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP5(1), ACPP(2), ENPP1(4), ENPP3(7), FLAD1(2), TYR(3)	440888	19	13	19	2	12	1	1	1	4	0	0.0131	0.374	1.000
8	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	23498	1	1	1	0	1	0	0	0	0	0	0.677	0.375	1.000
9	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(6), GABRA2(4), GABRA3(6), GABRA4(3), GABRA5(1), GABRA6(8), PRKCE(2)	352674	30	17	28	8	21	2	1	4	2	0	0.0353	0.395	1.000
10	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(3), HLA-DRA(3), HLA-DRB1(2)	138490	8	7	8	3	7	0	0	0	1	0	0.177	0.436	1.000
11	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(1), NR3C1(3), PPARG(2), RETN(1), RXRA(2)	266387	10	9	10	3	5	1	0	2	2	0	0.235	0.492	1.000
12	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(2)	51141	2	2	2	1	2	0	0	0	0	0	0.710	0.509	1.000
13	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(2), CCND1(1), CCNE1(1), CCNE2(3), CDK4(2), CDKN1B(1), E2F1(2), E2F2(1), E2F4(1), PRB1(8)	385295	22	16	22	5	14	0	2	4	2	0	0.0925	0.511	1.000
14	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), MIOX(1)	387400	11	8	11	3	3	4	0	2	2	0	0.218	0.597	1.000
15	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYB(1), RB1(2), SP1(2)	305594	5	5	5	1	2	1	0	0	1	1	0.404	0.609	1.000
16	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	HMGCL(3), OXCT1(1)	154223	4	4	4	1	2	1	0	1	0	0	0.562	0.609	1.000
17	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(1), PSMA4(1), PSMA5(2), PSMA6(1), PSMB10(1), PSMB2(1), PSMB7(1), PSMB8(3)	403101	12	9	12	2	5	1	2	3	1	0	0.179	0.625	1.000
18	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(3), PARK2(2), SNCA(1), SNCAIP(12), UBE2E2(1), UBE2F(1), UBE2G2(1)	294913	21	17	21	5	15	4	0	1	1	0	0.0767	0.636	1.000
19	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(3), CD4(1), HLA-DRA(3), HLA-DRB1(2), IL1B(1), IL4(1), IL5RA(7)	243218	18	15	17	9	14	0	0	0	4	0	0.195	0.643	1.000
20	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	MYC(2), SP1(2), WT1(3)	286637	7	7	7	1	4	1	1	1	0	0	0.209	0.653	1.000
21	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(4), SRP19(1), SRP54(1), SRP68(1), SRP72(1), SRP9(1)	348713	9	9	7	2	5	0	0	3	1	0	0.363	0.682	1.000
22	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2)	363466	12	9	12	4	5	3	0	2	2	0	0.244	0.684	1.000
23	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2)	363466	12	9	12	4	5	3	0	2	2	0	0.244	0.684	1.000
24	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(2), FYN(1), MAPK14(3), THBS1(10)	339453	16	12	16	4	12	0	0	1	3	0	0.110	0.689	1.000
25	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CDKN1B(1), CUL1(2), E2F1(2), RB1(2), TFDP1(1)	393491	9	8	9	2	3	1	1	1	2	1	0.204	0.703	1.000
26	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH6(2), ADH7(1), ADHFE1(2)	257435	33	19	32	11	23	3	2	3	2	0	0.138	0.733	1.000
27	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(7), CHKA(1), PCYT1A(2), PDHA2(6), SLC18A3(1)	316243	18	13	18	4	16	2	0	0	0	0	0.0195	0.767	1.000
28	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP5(1), ACP6(3), ACPP(2), ENPP1(4), ENPP3(7), FLAD1(2), MTMR1(1), MTMR6(1), TYR(3)	686084	24	16	24	3	17	1	1	1	4	0	0.00870	0.768	1.000
29	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	SLPI(2)	78608	2	2	2	1	2	0	0	0	0	0	0.680	0.780	1.000
30	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2)	97538	2	2	2	0	1	0	0	1	0	0	0.479	0.804	1.000
31	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	CCND1(1), CDK4(2), CDKN1A(1), CDKN1B(1), E2F1(2), E2F2(1), PRB1(8)	321365	16	13	16	5	11	1	1	2	1	0	0.205	0.814	1.000
32	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(13), CR2(10), FCGR2B(1), HLA-DRA(3), HLA-DRB1(2), ITGAL(8), ITGB2(6), PTPRC(4)	687849	47	22	47	12	31	4	2	2	8	0	0.0166	0.835	1.000
33	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(4), NFKBIA(1), PLCB1(18), PRKCA(5), RELA(1)	374805	30	18	29	9	27	1	0	0	2	0	0.0536	0.836	1.000
34	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IL12B(1), IL18(2), IL2(1)	135129	5	4	5	3	4	1	0	0	0	0	0.636	0.849	1.000
35	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(3), BMPR1B(2), BMPR2(1)	285764	6	6	6	2	2	2	0	1	1	0	0.476	0.852	1.000
36	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(2), CYR61(1), DUSP14(1), IL18(2), IL1A(3), IL1R1(3), MYOG(2), NR4A3(3), WDR1(1)	486032	18	12	18	5	9	3	1	2	3	0	0.180	0.856	1.000
37	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSA(2), FARSB(3), GOT2(1), PAH(2), TAT(2), YARS(1), YARS2(2)	398378	15	12	15	4	10	2	0	1	2	0	0.0835	0.875	1.000
38	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(2), BCMO1(4), RDH5(1)	178438	8	7	8	5	5	0	1	0	2	0	0.583	0.910	1.000
39	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(1), EPX(4), LPO(4), MPO(2), PRDX2(1), PRDX6(1), TPO(11)	541448	25	17	25	8	19	2	0	3	1	0	0.0477	0.926	1.000
40	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(5), IARS(5), LARS(1), PDHA2(6)	460023	17	11	17	3	13	0	1	1	2	0	0.0758	0.926	1.000
41	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(3), CARS2(1), CDO1(2), GOT2(1), LDHAL6B(1), LDHC(3), MPST(1), SDS(1), SULT1B1(3), SULT1C2(1), SULT1C4(3), SULT4A1(3)	572197	23	17	23	7	17	0	3	0	3	0	0.0776	0.932	1.000
42	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	APAF1(1), CASP9(2), DAXX(5), FAS(1), FASLG(2), HSPB1(2), IL1A(3), MAPKAPK2(2), MAPKAPK3(1)	520183	19	15	19	6	10	3	2	2	2	0	0.160	0.935	1.000
43	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(1), ALDOB(4)	180250	5	4	4	1	5	0	0	0	0	0	0.183	0.939	1.000
44	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(3), GAD1(4), HDC(5), PNMT(2), TH(3), TPH1(1)	273937	18	13	17	9	15	1	1	0	1	0	0.237	0.940	1.000
45	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(2), AASS(1), KARS(2)	213100	5	5	5	1	5	0	0	0	0	0	0.366	0.941	1.000
46	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(4), POLR2A(1), POLR2B(6), POLR2E(1), POLRMT(1)	611775	13	10	13	1	6	2	0	2	3	0	0.0240	0.941	1.000
47	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), FARS2(2), GOT2(1), PAH(2), TAT(2), YARS(1)	381516	10	9	10	2	9	1	0	0	0	0	0.0603	0.942	1.000
48	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(3), CDC25B(1), CDKN1A(1), NEK1(1), WEE1(2)	318318	8	6	8	2	3	2	1	1	1	0	0.386	0.942	1.000
49	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(2), PLCD1(1), PRKCA(5), TGM2(2)	227613	10	8	10	4	8	1	0	0	1	0	0.158	0.943	1.000
50	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT2(1), TAT(2)	120422	3	3	3	2	3	0	0	0	0	0	0.661	0.945	1.000
51	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(2), CCNE1(1), CDC34(1), CUL1(2), E2F1(2), RB1(2), TFDP1(1)	390586	11	8	11	4	5	1	1	1	2	1	0.339	0.948	1.000
52	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(2), IFNGR1(2), IFNGR2(1), JAK2(1), LIN7A(3), NFKB1(4), NFKBIA(1), RB1(2), RELA(1), TNFRSF1A(1), TNFRSF1B(2), USH1C(1), WT1(3)	785688	24	15	24	8	11	0	1	6	5	1	0.296	0.950	1.000
53	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH5(1), ADH6(2), ADH7(1), ADHFE1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1)	603202	44	22	43	14	27	6	2	5	4	0	0.0453	0.953	1.000
54	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(1), CSF1(3), CSF3(2), EPO(2), IL2(1), IL4(1), IL7(2), IL9(1)	276624	13	10	13	8	8	1	0	1	3	0	0.486	0.955	1.000
55	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(4), GGT1(1)	186246	5	5	5	3	3	0	0	1	1	0	0.566	0.957	1.000
56	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(1), ITGA4(13), ITGAL(8), ITGB1(2), ITGB2(6), SELE(8), SELL(3)	549229	41	22	41	12	30	2	1	2	6	0	0.0430	0.958	1.000
57	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	CCND1(1), CCNE1(1), CDK4(2), CDK6(1), CDKN1A(1), CDKN1B(1), E2F1(2), HRAS(2), MAPK1(2), MAPK3(1), NFKB1(4), NFKBIA(1), PIK3CA(3), RAF1(3), RB1(2), RELA(1), TFDP1(1)	901461	29	19	29	8	15	4	1	4	4	1	0.0689	0.960	1.000
58	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), EHHADH(1), HADHA(1), SDS(1)	554833	15	10	15	6	7	3	0	3	2	0	0.315	0.965	1.000
59	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(1), ADORA3(4), P2RY1(1), P2RY2(5)	271700	11	8	11	7	6	2	0	0	3	0	0.280	0.972	1.000
60	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	HRAS(2), MAPK1(2), MAPK3(1), NGFR(5), RAF1(3)	372233	13	10	13	5	8	2	0	2	1	0	0.192	0.972	1.000
61	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS2(2), SULT1A2(1), SULT1E1(6), SULT2A1(4), SUOX(1)	279100	14	9	13	5	10	0	0	2	2	0	0.330	0.973	1.000
62	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(2), NDUFB5(2), NDUFS2(1)	320708	5	5	5	1	4	0	0	1	0	0	0.450	0.975	1.000
63	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	MAPK1(2), MAPK14(3), NFE2L2(2), PRKCA(5)	406195	12	9	12	4	8	2	0	1	1	0	0.231	0.976	1.000
64	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(1), GPR109B(1), GPR161(3), GPR171(3), GPR18(1), GPR34(2), GPR39(3), GPR45(2), GPR65(2), GPR75(3), GPR81(2)	447058	23	18	23	11	18	1	0	0	4	0	0.0520	0.977	1.000
65	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(6), ALPP(2), ALPPL2(6), GGH(1)	291793	17	12	16	7	16	0	0	0	1	0	0.0996	0.978	1.000
66	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(1), POLD2(1), POLE(6), POLL(4), POLQ(9)	764678	21	16	21	5	12	0	1	5	3	0	0.0584	0.978	1.000
67	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(1), EPX(4), LPO(4), MPO(2), PRDX6(1), TPO(11)	534598	24	16	24	8	18	2	0	3	1	0	0.0648	0.980	1.000
68	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	SDHA(1), SDHC(1), SDHD(1), UQCRC1(1)	305187	4	4	4	1	3	0	0	0	1	0	0.469	0.981	1.000
69	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(2), CCND1(1), CCND2(1), CCNE1(1), CDC25A(3), CDK4(2), CDK6(1), CDKN1A(1), CDKN1B(1), CDKN2C(1), E2F1(2), RB1(2), RBL1(2), TFDP1(1)	710279	21	14	21	5	11	1	3	3	2	1	0.0740	0.981	1.000
70	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(1), HLA-DRA(3), HLA-DRB1(2), IL10(2), IL2(1), IL4(1)	179976	11	10	11	7	10	0	0	0	1	0	0.432	0.983	1.000
71	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	CDKN1A(1), EPO(2), EPOR(1), GRIN1(3), JAK2(1), NFKB1(4), NFKBIA(1), RELA(1)	571670	14	12	14	4	8	1	1	1	3	0	0.244	0.985	1.000
72	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(1)	144548	1	1	1	1	1	0	0	0	0	0	0.869	0.985	1.000
73	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(3), GOT2(1), LDHC(3), MPST(1)	312918	8	7	8	3	7	0	1	0	0	0	0.358	0.985	1.000
74	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(3), CDC25B(1), CDC25C(1), PRKCA(5), PTPRA(2), SRC(1)	424371	13	9	13	4	8	3	1	1	0	0	0.181	0.985	1.000
75	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), UXS1(1)	177160	2	2	2	5	0	0	1	0	1	0	0.995	0.986	1.000
76	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(1), E2F1(2), MYC(2), PIK3CA(3), POLR1A(5), POLR1B(4), RB1(2), TBX2(2)	842415	21	12	21	4	16	2	0	0	2	1	0.0248	0.986	1.000
77	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(2), AASDH(3), AASS(1), KARS(2)	315378	8	7	8	2	8	0	0	0	0	0	0.342	0.987	1.000
78	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF3(2), EPO(2), FLT3(7), IL1A(3), IL9(1), KITLG(1)	377058	16	12	16	8	10	0	1	2	3	0	0.442	0.988	1.000
79	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(1), IL10(2), IL12B(1), IL15(1), IL16(5), IL18(2), IL1A(3), IL2(1), IL4(1), IL9(1), LTA(1)	450320	20	14	20	7	14	1	1	1	3	0	0.0905	0.989	1.000
80	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(4), DAXX(5), HRAS(2), PAX3(1), PML(1), RARA(1), RB1(2), SP100(1), TNFRSF1A(1), TNFRSF1B(2)	821350	20	15	20	7	10	3	2	2	2	1	0.296	0.989	1.000
81	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(4), GBA3(4), LPO(4), MPO(2), PRDX2(1), PRDX6(1), TPO(11), TYR(3)	441933	30	20	30	10	23	2	0	3	2	0	0.0473	0.990	1.000
82	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(11), CD28(1), CD3D(2), ITGAL(8), ITGB2(6), PTPRC(4), THY1(1)	484241	33	17	32	11	25	2	1	2	3	0	0.0566	0.990	1.000
83	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(11), CD34(1), CD3D(2), CD4(1), CSF3(2), KITLG(1)	279767	18	10	17	7	14	1	0	2	1	0	0.216	0.991	1.000
84	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), HADHA(1), HADHB(2), HSD17B4(1), MECR(3)	389784	8	8	8	4	4	0	0	1	3	0	0.603	0.991	1.000
85	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSS(2), NFKB1(4), NOX1(3), RELA(1), XDH(13)	449339	23	19	23	9	18	1	2	1	1	0	0.146	0.992	1.000
86	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(1), CS(1), FH(2), IDH2(1), OGDH(3), SDHA(1)	433193	9	8	9	4	7	0	0	0	2	0	0.373	0.992	1.000
87	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	11	CDC42(1), WASL(4)	353229	5	5	5	2	3	0	0	1	1	0	0.709	0.993	1.000
88	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLUD2(2)	208575	2	2	2	2	0	0	1	0	1	0	0.917	0.994	1.000
89	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), ACO2(1), FH(2), IDH1(1), IDH2(1), MDH2(2)	409679	8	6	8	3	5	0	1	0	2	0	0.363	0.994	1.000
90	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(1), ATM(2), BAX(2), CCND1(1), CCNE1(1), CDK4(2), CDKN1A(1), E2F1(2), RB1(2), TIMP3(1)	786451	15	11	15	5	6	3	1	2	2	1	0.357	0.995	1.000
91	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA3(4), GGT1(1)	245631	5	5	5	3	3	0	0	1	1	0	0.615	0.996	1.000
92	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), EHHADH(1), HADHA(1), SDS(1)	222237	4	4	4	3	3	0	0	1	0	0	0.765	0.996	1.000
93	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	EHHADH(1), GCDH(1), HADHA(1), SDS(1)	357910	4	4	4	2	2	1	0	1	0	0	0.678	0.996	1.000
94	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(2), RDH11(1), RDH12(1), RDH13(1)	220533	5	5	5	9	4	0	0	0	1	0	0.987	0.996	1.000
95	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(1), CFLAR(1)	178716	2	2	2	2	1	0	0	1	0	0	0.926	0.996	1.000
96	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), UGP2(1), UXS1(1)	225714	3	3	3	5	1	0	1	0	1	0	0.984	0.996	1.000
97	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(5), PLCG1(1), PRKCA(5), PTK2B(2)	307882	13	8	13	7	9	2	0	0	2	0	0.369	0.997	1.000
98	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), CSF1(3), IL1B(1), MST1(1), MST1R(2)	299975	8	7	8	4	5	1	1	0	1	0	0.564	0.997	1.000
99	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(4), DFFB(1), GZMA(5), HMGB2(1), PRF1(2), SET(1)	484304	14	10	14	5	9	0	1	2	2	0	0.475	0.997	1.000
100	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	DAG1(2), GNAQ(1), ITPKB(2)	275692	5	5	5	2	5	0	0	0	0	0	0.371	0.997	1.000
101	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(5), DPYD(18), DPYS(6), ENPP1(4), ENPP3(7), PANK2(2), PANK3(2), PANK4(1), PPCS(1), UPB1(1)	634552	47	18	46	11	37	2	1	3	4	0	0.00523	0.997	1.000
102	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT2(1), FUT3(2), FUT5(1), FUT6(1)	227287	5	5	5	5	2	0	1	1	1	0	0.854	0.997	1.000
103	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(1), ESR1(2), GREB1(5), HSPB1(2), MTA3(1), PDZK1(1), TUBA8(1)	490581	14	10	14	5	10	0	1	2	1	0	0.209	0.997	1.000
104	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	CBS(2), MUT(1)	233417	3	3	3	2	3	0	0	0	0	0	0.720	0.998	1.000
105	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(4), CLOCK(1), CRY1(1), CRY2(2), CSNK1E(1), PER1(3)	385974	12	10	12	5	7	1	1	1	2	0	0.501	0.998	1.000
106	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(2), CDC25A(3), CDC25B(1), CDC25C(1), CDK4(2), MYT1(4), RB1(2), WEE1(2)	764947	17	12	17	6	7	1	1	4	3	1	0.469	0.998	1.000
107	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(4), GBA3(4), LPO(4), MPO(2), PRDX6(1), TPO(11)	384628	26	18	26	10	19	2	0	3	2	0	0.102	0.998	1.000
108	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(2), IFNGR2(1), JAK1(1), JAK2(1), STAT1(3)	372106	8	4	8	7	1	0	0	4	3	0	0.997	0.998	1.000
109	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), ALAS2(1), CPOX(2), PPOX(1)	345125	5	5	5	2	4	0	1	0	0	0	0.493	0.998	1.000
110	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(6), G6PD(1), GCLC(1), GCLM(2), GGT1(1), GPX3(1), GPX5(1), GSS(2), GSTA1(2), GSTA2(2), GSTM2(2), GSTM3(2), GSTM4(2), GSTM5(1), IDH1(1), IDH2(1), MGST1(1), MGST2(1), PGD(2)	822222	32	19	31	10	22	0	2	4	4	0	0.0287	0.998	1.000
111	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(2), ACAA2(1), EHHADH(1), HADHA(1), HADHB(2), SDS(1)	383253	8	8	8	4	5	0	0	1	2	0	0.598	0.998	1.000
112	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(2), NR0B2(1), NR1H4(2), RXRA(2)	247883	7	6	7	5	5	1	0	0	1	0	0.601	0.998	1.000
113	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), ACO2(1), CS(1), HAO1(4), HAO2(5), MDH2(2)	584357	14	12	14	6	9	1	1	0	3	0	0.270	0.999	1.000
114	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(5), POLR1B(4), POLR2A(1), POLR2B(6), POLR2E(1), POLR3A(2), POLR3B(4), POLR3G(1), POLR3GL(1)	1071884	25	18	25	5	15	1	1	3	5	0	0.0344	0.999	1.000
115	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(4), HRAS(2), MAPK1(2), MAPK3(1), MYC(2), NFKB1(4), NFKBIA(1), PLCB1(18), PRKCA(5), RAF1(3), RELA(1)	710758	43	22	42	14	32	5	1	2	3	0	0.0201	0.999	1.000
116	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP7(2), DFFB(1), HMGB2(1), TOP2A(2), TOP2B(1)	411875	7	7	7	3	6	1	0	0	0	0	0.622	0.999	1.000
117	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), OAT(2)	250175	3	3	3	2	2	1	0	0	0	0	0.743	0.999	1.000
118	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(5), PSAT1(1)	222631	6	5	6	4	6	0	0	0	0	0	0.739	0.999	1.000
119	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(4), ENO1(2), PFKL(2), PGK1(1), PKLR(4)	420891	13	10	12	5	10	1	0	1	1	0	0.128	0.999	1.000
120	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(1), ITGAL(8), ITGAM(9), ITGB2(6), SELE(8), SELL(3)	470384	35	19	35	15	22	2	1	3	7	0	0.187	0.999	1.000
121	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BAX(2), BCL10(1), BCL2L11(3), CASP8AP2(1), CASP9(2), CES1(1)	491053	11	8	11	7	6	2	1	0	2	0	0.801	0.999	1.000
122	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), IL10(2), IL10RA(3), IL1A(3), JAK1(1), STAT1(3), STAT3(1), STAT5A(1)	558340	15	13	15	7	8	1	1	3	2	0	0.460	0.999	1.000
123	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(1), ITGA4(13), ITGAL(8), ITGAM(9), ITGB1(2), ITGB2(6), SELE(8), SELL(3), SELP(10)	722789	60	23	60	20	43	2	2	5	8	0	0.0404	0.999	1.000
124	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(2), F2(3), F2R(2), F5(9), F7(2), FGA(11), FGG(2), PROC(1), PROS1(4), SERPINC1(1), TFPI(4)	749885	41	24	40	12	28	5	0	4	4	0	0.0633	0.999	1.000
125	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), ACO2(1), AFMID(2), CS(1), HAO1(4), HAO2(5), MDH2(2)	612327	16	14	16	9	10	1	2	0	3	0	0.452	1.000	1.000
126	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDPS(1), HMGCR(3), MVK(2)	502576	8	7	8	4	5	0	0	2	1	0	0.645	1.000	1.000
127	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), BHMT(1), CBS(2), DNMT1(6), DNMT3A(2), DNMT3B(3), MARS2(2), MAT1A(1), MTR(2)	807056	20	14	20	9	11	2	4	1	2	0	0.370	1.000	1.000
128	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(4), EP300(7), ESR1(2), MAPK1(2), MAPK3(1), PELP1(5), SRC(1)	669543	22	15	22	8	17	0	1	2	2	0	0.313	1.000	1.000
129	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(2), CD4(1), FYN(1), HLA-DRA(3), HLA-DRB1(2), LCK(3), PTPRC(4), ZAP70(2)	403063	18	13	18	8	15	1	0	1	1	0	0.308	1.000	1.000
130	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(5), DPYD(18), DPYS(6), ENPP1(4), ENPP3(7), ILVBL(2), PANK2(2), PANK3(2), PANK4(1), PPCS(1), UPB1(1), VNN1(1)	788259	50	18	49	13	39	2	1	4	4	0	0.00535	1.000	1.000
131	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(2), ALOX15(4), ALOX15B(2), ALOX5(4), DPEP1(2), GGT1(1), LTA4H(2), PLA2G2A(1), PLA2G6(2), PTGDS(1), PTGIS(4), PTGS1(5), PTGS2(3), TBXAS1(6)	685266	39	22	39	15	30	2	1	3	3	0	0.0226	1.000	1.000
132	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(1), MTMR6(1), NFS1(1), TPK1(2)	294608	5	5	5	3	5	0	0	0	0	0	0.743	1.000	1.000
133	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(3), GABRA1(6), GABRA2(4), GABRA3(6), GABRA4(3), GABRA5(1), GABRA6(8), GPHN(1), SRC(1), UBQLN1(2)	535378	35	18	33	13	26	3	1	3	2	0	0.112	1.000	1.000
134	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(11), CD28(1), CD3D(2), CD4(1), ITGAL(8), ITGB2(6), PTPRC(4), THY1(1)	507511	34	17	33	13	26	2	1	2	3	0	0.0949	1.000	1.000
135	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	CDC42(1), PDGFRA(9), PIK3CA(3), WASL(4)	594949	17	13	17	7	9	1	0	4	3	0	0.629	1.000	1.000
136	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	CD3D(2), HLA-A(2), ITGAL(8), ITGB2(6), PRF1(2)	398334	20	15	20	10	13	2	1	1	3	0	0.367	1.000	1.000
137	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(2), FDPS(1), HMGCR(3), MVK(2), NSDHL(1)	600353	9	8	9	4	6	0	0	2	1	0	0.584	1.000	1.000
138	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	BCAR1(2), CDKN1B(1), ITGB1(2), MAPK1(2), MAPK3(1), PDPK1(2), PIK3CA(3), PTEN(1), PTK2(2), SHC1(1), SOS1(3)	879354	20	14	19	6	14	3	0	1	2	0	0.220	1.000	1.000
139	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	32	AKT2(1), AKT3(2), BTK(4), DAPP1(3), GSK3B(1), IARS(5), IGFBP1(1), INPP5D(13), PDK1(1), PIK3CA(3), PPP1R13B(2), PTEN(1), RPS6KA1(3), RPS6KB1(1), SFN(1), SHC1(1), SOS1(3), SOS2(5), TEC(2), YWHAE(1), YWHAG(1), YWHAQ(2)	1620091	57	26	57	15	36	5	5	4	7	0	0.0158	1.000	1.000
140	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BIRC3(1), CASP8(1), TNFRSF1A(1), TNFRSF1B(2)	373858	5	5	5	3	5	0	0	0	0	0	0.649	1.000	1.000
141	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL13RA2(1), IL4R(3), JAK1(1), JAK2(1), TYK2(3)	477408	11	10	11	7	5	0	0	4	2	0	0.843	1.000	1.000
142	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL13RA2(1), IL4R(3), JAK1(1), JAK2(1), TYK2(3)	477408	11	10	11	7	5	0	0	4	2	0	0.843	1.000	1.000
143	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	MAP2K3(2), MAPK1(2), MAPK14(3), MAPK3(1), NFKB1(4), PIK3CA(3), RB1(2), RELA(1), SP1(2)	886198	20	16	20	9	13	3	0	1	2	1	0.487	1.000	1.000
144	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(3), GNAQ(1), GNAS(4), HRAS(2), LIMK1(1), MAPK1(2), MAPK3(1), MYL2(2), NOX1(3), PIK3C2G(13), PLCB1(18), PPP1R12B(3), PRKCA(5), PTK2(2), RAF1(3), ROCK2(4)	1142916	67	24	65	23	50	5	1	6	5	0	0.0395	1.000	1.000
145	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAP3K14(2), MAPK14(3), NFKB1(4), RELA(1), TNFRSF13B(1), TNFRSF17(1), TRAF3(3), TRAF5(2), TRAF6(2)	659684	20	14	20	6	16	1	0	3	0	0	0.159	1.000	1.000
146	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK2(5), HK3(3), PGM1(1), PGM3(1)	468673	12	8	12	5	8	2	0	1	1	0	0.288	1.000	1.000
147	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(11), CD44(1), CSF1(3), FCGR3A(2), IL1B(1), SELL(3), SPN(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF8(1), TNFSF8(2)	593002	28	15	28	10	24	1	1	0	2	0	0.0685	1.000	1.000
148	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD3D(2), CD86(8), CTLA4(1), HLA-DRA(3), HLA-DRB1(2), ICOS(1), IL2(1), ITK(8), LCK(3), PIK3CA(3), PTPN11(5)	583198	38	17	37	10	29	5	1	1	2	0	0.0451	1.000	1.000
149	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(1), MAPK1(2), MAPK3(1), STAT3(1), TYK2(3)	532469	9	7	9	6	3	1	0	3	2	0	0.819	1.000	1.000
150	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(1), ACOX3(2), FADS2(1), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2)	463120	21	13	21	10	14	1	1	2	3	0	0.335	1.000	1.000
151	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(6), CD2(11), CD33(6), CD5(2), IFNA1(1), IFNB1(1), IL10(2), IL12B(1), IL4(1), ITGAX(5), TLR2(4), TLR4(8), TLR7(4), TLR9(3)	844900	55	20	54	22	40	3	2	4	6	0	0.0171	1.000	1.000
152	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(5), ENPP1(4), ENPP3(7), NADSYN1(2), NMNAT2(1), NNMT(3), NNT(1), NT5E(1), NT5M(1), QPRT(2)	666990	27	16	27	10	18	2	1	1	5	0	0.168	1.000	1.000
153	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(3), CS(1), ME1(4), PC(1), SLC25A11(1)	426039	10	8	10	6	8	0	0	1	1	0	0.547	1.000	1.000
154	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(1), MAP3K14(2), NFKB1(4), NFKBIA(1), RELA(1)	407606	9	9	9	5	7	0	0	1	1	0	0.685	1.000	1.000
155	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(1), PSMA4(1), PSMA5(2), PSMA6(1), PSMB2(1), PSMB7(1), RPN2(1), UBE3A(4)	593531	13	11	13	5	7	2	1	2	1	0	0.457	1.000	1.000
156	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(2), CAPN1(1), GSK3B(1), MAPT(3)	414725	7	6	7	7	4	1	1	0	1	0	0.876	1.000	1.000
157	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(2), CDC25A(3), CDC25B(1), CDC25C(1), MYT1(4), WEE1(2)	628119	13	9	13	6	6	1	1	3	2	0	0.690	1.000	1.000
158	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	BDH1(1), HMGCL(3), HMGCS2(7), OXCT1(1)	326748	12	8	11	6	7	3	0	2	0	0	0.619	1.000	1.000
159	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(6), GPT(1), LDHC(3), MAPK14(3)	410014	13	8	13	6	11	0	1	1	0	0	0.416	1.000	1.000
160	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK2(5), HK3(3), IMPA2(1), PGM1(1), PGM3(1)	533035	13	9	13	7	9	2	0	1	1	0	0.413	1.000	1.000
161	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), FUCA1(2), GLB1(2), HEXA(2), HEXB(2), LCT(13), MAN2C1(1), MANBA(3), NEU1(2), NEU2(2), NEU3(1)	751469	31	18	31	11	24	2	0	4	1	0	0.137	1.000	1.000
162	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(3), ACO1(1), ACO2(1), FH(2), IDH1(1), IDH2(1), MDH2(2)	611276	11	7	11	7	8	0	1	0	2	0	0.601	1.000	1.000
163	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(4), CD2(11), CD3D(2), CD4(1), CXCR3(1), IL12B(1), IL12RB1(6), JAK2(1), STAT4(7), TYK2(3)	662380	37	18	36	14	25	3	1	7	1	0	0.148	1.000	1.000
164	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CBS(2), GGT1(1), MARS2(2), MAT1A(1), PAPSS2(2), SEPHS1(2)	571596	11	10	11	6	6	0	2	2	1	0	0.543	1.000	1.000
165	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2), EIF2AK4(2), GSK3B(1)	532252	5	4	5	5	4	0	0	0	1	0	0.930	1.000	1.000
166	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), FUCA1(2), GLB1(2), HEXA(2), HEXB(2), LCT(13), MAN2B1(2), MAN2B2(4), MAN2C1(1), MANBA(3), NEU1(2), NEU2(2), NEU3(1)	926306	37	20	37	13	29	2	1	4	1	0	0.0757	1.000	1.000
167	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(4), AKR1D1(6), CYP11B1(5), CYP11B2(3), CYP17A1(1), CYP21A2(4), HSD11B1(1), HSD11B2(1), HSD3B1(4)	445945	29	16	28	15	18	2	2	3	4	0	0.186	1.000	1.000
168	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(4), AKR1D1(6), CYP11B1(5), CYP11B2(3), CYP17A1(1), CYP21A2(4), HSD11B1(1), HSD11B2(1), HSD3B1(4)	445945	29	16	28	15	18	2	2	3	4	0	0.186	1.000	1.000
169	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1G(2), HDAC9(16), MEF2A(2), MEF2C(1), MEF2D(1)	340171	22	15	20	10	18	1	0	1	2	0	0.339	1.000	1.000
170	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(1), CREBBP(4), EP300(7), HDAC3(3), NFKB1(4), NFKBIA(1), RELA(1), TNFRSF1A(1), TNFRSF1B(2), TRAF6(2)	1016261	26	14	26	8	20	0	2	2	2	0	0.160	1.000	1.000
171	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(1), ATP6AP1(1), ATP6V0A1(4), ATP6V0A4(7), ATP6V1B2(2), ATP6V1C2(4), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(2), FDXR(4)	733352	30	16	30	11	19	1	0	4	6	0	0.126	1.000	1.000
172	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(1), ATP6V0A1(4), ATP6V0A4(7), ATP6V1B2(2), ATP6V1C2(4), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(2)	689055	26	15	26	10	16	1	0	3	6	0	0.187	1.000	1.000
173	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(1), ATP6V0A1(4), ATP6V0A4(7), ATP6V1B2(2), ATP6V1C2(4), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(2)	689055	26	15	26	10	16	1	0	3	6	0	0.187	1.000	1.000
174	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(1), ATP6V0A1(4), ATP6V0A4(7), ATP6V1B2(2), ATP6V1C2(4), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(2)	689055	26	15	26	10	16	1	0	3	6	0	0.187	1.000	1.000
175	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(2), CHST11(2), CHST12(2), CHST13(1), CHSY1(6), DSE(6), XYLT1(5)	608427	24	16	24	12	16	3	3	1	1	0	0.251	1.000	1.000
176	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), EHHADH(1), HADHA(1), HSD17B4(1), SIRT5(2), SIRT7(1), VNN2(4)	543871	11	10	11	7	7	1	0	2	1	0	0.767	1.000	1.000
177	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(3), F2R(2), F2RL3(1), HRAS(2), ITGA1(11), ITGB1(2), MAPK1(2), MAPK3(1), PLA2G4A(1), PLCB1(18), PRKCA(5), PTGS1(5), PTK2(2), RAF1(3), SRC(1), SYK(4), TBXAS1(6)	1111808	69	24	67	25	54	6	0	4	5	0	0.0272	1.000	1.000
178	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(2), METTL2B(2), PCYT1A(2), PCYT1B(3), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(3)	643103	18	12	18	9	11	3	1	2	1	0	0.508	1.000	1.000
179	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(1), IFNB1(1), JAK1(1), STAT1(3), TYK2(3)	491562	10	9	10	7	5	0	0	4	1	0	0.899	1.000	1.000
180	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), DPM1(1), FUT8(2), MAN1A1(3), MAN1B1(1), MGAT1(1), MGAT3(4), MGAT4A(2), MGAT5(1), RPN2(1), ST6GAL1(1)	912692	21	16	21	9	14	3	2	1	1	0	0.223	1.000	1.000
181	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDC25A(3), CDC25B(1), CDC25C(1), SHH(1)	399880	6	6	6	4	3	1	1	1	0	0	0.808	1.000	1.000
182	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT2(1), AGPAT3(2), AGPAT4(3), AGPS(1), ENPP6(3), PAFAH1B1(1), PAFAH1B2(1), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), PLD1(3), PLD2(2), PPAP2B(4), PPAP2C(2)	1066225	40	18	39	13	25	3	1	5	6	0	0.0793	1.000	1.000
183	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(6), ACTN3(3), BCAR1(2), CTNNA1(2), CTNNA2(8), CTNNB1(3), PTK2(2), SRC(1), VCL(2)	862284	30	17	30	11	21	2	1	1	4	1	0.0610	1.000	1.000
184	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(2), CASP8(1), MAPK1(2), MAPK3(1), NFKB1(4), NSMAF(1), RAF1(3), RELA(1), TNFRSF1A(1)	930596	16	11	16	5	12	2	0	1	1	0	0.184	1.000	1.000
185	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	EDN1(2), EP300(7), EPO(2), NOS3(2), VHL(2)	782000	15	12	15	7	9	0	1	2	3	0	0.597	1.000	1.000
186	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(2), ATR(8), CDC25C(1)	692949	11	10	11	6	8	0	1	1	1	0	0.760	1.000	1.000
187	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(2), MBTPS1(2), SCAP(1), SREBF1(3), SREBF2(1)	542730	9	9	9	8	7	1	0	0	1	0	0.842	1.000	1.000
188	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GCK(2), GFPT1(1), GNE(1), HEXA(2), HEXB(2), HK2(5), HK3(3), PGM3(1)	777172	17	12	17	8	11	2	0	4	0	0	0.452	1.000	1.000
189	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(1), SEC22B(1), SNAP25(2), TSNARE1(1), VAMP4(1), VAMP7(1)	757376	7	5	7	4	5	0	0	2	0	0	0.620	1.000	1.000
190	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(6), G6PD(1), GCLC(1), GCLM(2), GGT1(1), GPX3(1), GPX5(1), GPX6(6), GSS(2), GSTA1(2), GSTA2(2), GSTA5(1), GSTK1(1), GSTM2(2), GSTM3(2), GSTM4(2), GSTM5(1), IDH1(1), IDH2(1), MGST1(1), MGST2(1), OPLAH(2)	995275	40	20	39	16	28	1	2	4	5	0	0.0528	1.000	1.000
191	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP5(1), ACP6(3), ACPP(2), ALPI(2), ALPL(6), ALPP(2), ALPPL2(6), CMBL(1), CYP3A4(3), CYP3A43(4), CYP3A5(2), CYP3A7(7), DHRS1(2), DHRS2(1), DHRSX(2), PON1(4)	820325	48	23	46	21	35	1	2	3	7	0	0.128	1.000	1.000
192	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(3), ARHGEF1(1), GNA12(1), GNAQ(1), MYL2(2), MYLK(11), PLCB1(18), PPP1R12B(3), PRKCA(5), ROCK1(2)	950256	47	23	44	19	41	2	2	1	1	0	0.124	1.000	1.000
193	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(6), CPT1A(1), LEP(1), LEPR(6), PRKAA1(1), PRKAA2(4), PRKAB1(1), PRKAG1(1), PRKAG2(4)	667196	25	17	24	10	18	0	0	0	7	0	0.341	1.000	1.000
194	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(9), ABCB11(10), ABCB4(6), ABCC1(4), ABCC3(4)	649809	33	17	33	16	21	4	1	3	4	0	0.129	1.000	1.000
195	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), ACO2(1), CS(1), DLD(1), FH(2), IDH1(1), IDH2(1), IDH3A(3), IDH3B(1), IDH3G(1), MDH2(2), PC(1), PCK1(8), SDHA(1)	946711	25	17	25	10	18	0	2	2	3	0	0.171	1.000	1.000
196	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(1), PSMA4(1), PSMA5(2), PSMA6(1), PSMB2(1), PSMB7(1), PSMD1(1), PSMD12(1), PSMD13(2), PSMD2(1)	737820	13	10	13	6	7	1	2	2	1	0	0.588	1.000	1.000
197	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	GTF2E1(1), GTF2E2(2), GTF2F2(1), GTF2H1(1), POLR1A(5), POLR1B(4), POLR2A(1), POLR2B(6), POLR2E(1), POLR3B(4), POLR3E(1), TAF9(1), TBP(2)	1603109	30	21	30	7	22	1	0	3	4	0	0.0342	1.000	1.000
198	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	38	ATF2(1), CDC42(1), DAXX(5), DDIT3(1), ELK1(1), HRAS(2), HSPB1(2), MAP3K5(7), MAP3K7(1), MAP3K9(8), MAPK14(3), MAPKAPK2(2), MEF2A(2), MEF2C(1), MEF2D(1), MKNK1(1), MYC(2), PLA2G4A(1), RPS6KA5(1), SHC1(1), STAT1(3)	1641100	47	25	46	12	29	6	0	11	1	0	0.0344	1.000	1.000
199	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(1), ELK1(1), HRAS(2), MAPK3(1), NGFR(5), PIK3CA(3), PLCG1(1), RAF1(3), SHC1(1), SOS1(3)	870000	21	13	21	8	14	5	0	2	0	0	0.281	1.000	1.000
200	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(5), BST1(1), ENPP1(4), ENPP3(7), NADSYN1(2), NMNAT2(1), NMNAT3(2), NNMT(3), NNT(1), NT5C1A(2), NT5C1B(6), NT5C3(2), NT5E(1), NT5M(1), NUDT12(1), QPRT(2)	985731	41	18	41	16	28	3	2	2	6	0	0.137	1.000	1.000
201	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(3), ALOX12(2), ALOX15(4), ALOX5(4), CYP4F2(2), CYP4F3(4), EPX(4), GGT1(1), LPO(4), LTA4H(2), MPO(2), PLA2G1B(1), PLA2G2A(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), PRDX2(1), PRDX6(1), PTGDS(1), PTGIS(4), PTGS1(5), PTGS2(3), TBXAS1(6), TPO(11)	1276713	79	24	79	27	63	6	0	6	4	0	0.000874	1.000	1.000
202	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GALNS(2), GLB1(2), GNS(1), HEXA(2), HEXB(2), IDS(5), IDUA(1), LCT(13), NAGLU(1)	654358	29	15	29	13	21	3	0	5	0	0	0.312	1.000	1.000
203	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(2), CNR1(1), CNR2(3), DNMT1(6), MTNR1A(2), PTAFR(1), PTGDR(2), PTGER2(1), PTGFR(6), PTGIR(1), TBXA2R(2)	509801	27	17	27	16	20	4	1	1	1	0	0.220	1.000	1.000
204	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), ELK1(1), EPO(2), EPOR(1), HRAS(2), JAK2(1), MAPK3(1), PLCG1(1), RAF1(3), SHC1(1), SOS1(3), STAT5A(1), STAT5B(1)	974049	19	12	19	8	9	4	2	3	1	0	0.343	1.000	1.000
205	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(2), CRK(1), CXCL12(1), CXCR4(1), GNAQ(1), HRAS(2), MAPK1(2), MAPK3(1), NFKB1(4), PIK3C2G(13), PIK3CA(3), PLCG1(1), PRKCA(5), PTK2(2), PTK2B(2), RAF1(3), RELA(1)	1253388	45	20	44	16	34	5	1	3	2	0	0.0608	1.000	1.000
206	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(3), HRAS(2), JAK2(1), MAPK3(1), RAF1(3), SHC1(1), SOS1(3), STAT5A(1), STAT5B(1)	803664	16	12	16	8	9	3	1	3	0	0	0.514	1.000	1.000
207	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(12), COL4A2(8), COL4A3(11), COL4A4(23), COL4A5(13), COL4A6(14), SLC23A1(1), SLC2A1(1), SLC2A3(2)	1134143	85	25	82	18	69	4	3	9	0	0	0.0762	1.000	1.000
208	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(3), F2(3), F2R(2), FGA(11), FGG(2), PLAT(1), PLG(11), SERPINB2(3), SERPINE1(2)	607801	38	21	37	15	31	1	2	2	2	0	0.281	1.000	1.000
209	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(1), CSF1(3), CSF3(2), HLA-DRA(3), HLA-DRB1(2), IFNA1(1), IFNB1(1), IL10(2), IL12B(1), IL15(1), IL1A(3), IL2(1), IL4(1), IL7(2), LTA(1)	600676	25	16	25	13	17	2	1	2	3	0	0.252	1.000	1.000
210	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	EIF4A2(2), EIF4G1(7), EIF4G3(6), GHR(7), MAPK1(2), MAPK14(3), MAPK3(1), MKNK1(1), PABPC1(1), PDPK1(2), PIK3CA(3), PRKCA(5), PTEN(1), RPS6KB1(1)	1295086	42	20	41	15	27	6	2	2	5	0	0.197	1.000	1.000
211	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR7(2), FDPS(1), GGCX(1), HMGCR(3), HSD17B7(1), MVK(2), NSDHL(1)	879935	11	9	11	7	6	1	1	2	1	0	0.752	1.000	1.000
212	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(3), ACO1(1), ACO2(1), CLYBL(2), CS(1), DLD(1), FH(2), IDH1(1), IDH2(1), IDH3A(3), IDH3B(1), IDH3G(1), MDH2(2), OGDH(3), OGDHL(9), PC(1), PCK1(8), SDHA(1), SDHC(1), SDHD(1)	1371702	44	21	44	17	32	0	3	3	6	0	0.0568	1.000	1.000
213	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(4), CD3D(2), CXCR3(1), ETV5(1), IL12B(1), IL12RB1(6), IL18(2), IL18R1(6), JAK2(1), MAPK14(3), STAT4(7), TYK2(3)	846011	37	19	37	16	26	2	1	7	1	0	0.351	1.000	1.000
214	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(3), CA1(2), CA12(1), CA2(1), CA3(1), CA4(1), CA5B(1), CA8(1), CA9(2), CPS1(8), HAL(3)	859080	24	14	24	10	18	1	0	3	2	0	0.294	1.000	1.000
215	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(8), BIN1(3), CALM1(1), DNM1(3), EPN1(5), PICALM(1), SYNJ1(9), SYNJ2(6), SYT1(4)	978405	40	18	40	15	33	3	0	3	1	0	0.127	1.000	1.000
216	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(11), ACE2(1), AGT(2), AGTR1(2), AGTR2(1), ANPEP(6), CMA1(1), CPA3(4), CTSA(3), CTSG(1), ENPEP(7), LNPEP(1), MAS1(2), MME(6), NLN(1), REN(1), THOP1(5)	964326	55	22	55	26	40	5	3	2	5	0	0.172	1.000	1.000
217	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(1), ANXA2(1), ANXA4(1), ANXA6(2), EDN1(2), EDNRA(3), HSD11B1(1), HSD11B2(1), PLA2G4A(1), PTGDR(2), PTGDS(1), PTGER2(1), PTGFR(6), PTGIR(1), PTGIS(4), PTGS1(5), PTGS2(3), TBXAS1(6)	933985	42	21	42	21	34	4	0	1	3	0	0.146	1.000	1.000
218	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(1), CS(1), DLAT(1), DLD(1), FH(2), IDH2(1), IDH3A(3), IDH3B(1), IDH3G(1), MDH2(2), OGDH(3), PC(1), PDHA2(6), PDHX(1), PDK1(1), PDK4(3), PDP2(2), SDHA(1), SDHC(1), SDHD(1)	1301090	34	18	34	12	26	0	1	3	4	0	0.0909	1.000	1.000
219	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(5), ATIC(2), GART(2), MTR(2)	818304	11	9	10	6	10	0	1	0	0	0	0.523	1.000	1.000
220	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(3), CA1(2), CA12(1), CA2(1), CA3(1), CA4(1), CA5B(1), CA8(1), CA9(2), CPS1(8), GLUD2(2), HAL(3)	960774	26	16	26	11	18	1	1	3	3	0	0.323	1.000	1.000
221	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(1), ATM(2), BRCA1(4), CDKN1A(1), MRE11A(1), NFKB1(4), NFKBIA(1), RAD50(1), RBBP8(2), RELA(1), TP73(2)	1315992	20	16	20	8	12	3	1	2	2	0	0.464	1.000	1.000
222	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(3), DIAPH1(5), FYN(1), GSN(2), HRAS(2), ITGA1(11), ITGB1(2), MAPK1(2), MAPK3(1), MYL2(2), MYLK(11), PIK3CA(3), PTK2(2), RAF1(3), ROCK1(2), SHC1(1), SRC(1), TLN1(5)	1701973	59	20	56	21	45	6	1	5	2	0	0.0491	1.000	1.000
223	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(1), CHUK(1), LTA(1), MAP2K3(2), MAP3K14(2), MAPK14(3), NFKB1(4), NFKBIA(1), RELA(1), TNFRSF1A(1)	1089418	17	14	17	9	13	1	0	2	1	0	0.556	1.000	1.000
224	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(2), ATR(8), BRCA1(4), CDC25A(3), CDC25B(1), CDC25C(1), CDC34(1), CDKN1A(1), EP300(7), MYT1(4), PRKDC(6), RPS6KA1(3), WEE1(2), YWHAQ(2)	1876534	45	22	45	12	29	2	4	5	5	0	0.0547	1.000	1.000
225	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH5(1), ADH6(2), ADH7(1), ADHFE1(2), AKR1A1(1), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH3B1(1), ALDH3B2(2), ALDH7A1(1), ALDOA(1), ALDOB(4), BPGM(1), DLAT(1), DLD(1), ENO1(2), FBP1(1), G6PC(4), GALM(2), GAPDH(1), GAPDHS(1), GCK(2), HK2(5), HK3(3), LDHAL6B(1), LDHC(3), PDHA2(6), PFKL(2), PGAM2(1), PGK1(1), PGK2(4), PGM1(1), PGM3(1), PKLR(4), PKM2(1)	2653947	102	31	100	41	69	11	4	11	7	0	0.00859	1.000	1.000
226	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(7), AMY2A(2), AMY2B(2), ASCC3(6), ATP13A2(4), DDX18(1), DDX4(5), DDX41(2), DDX50(4), DDX51(2), DDX52(2), DDX54(1), DDX55(1), DDX56(1), ENPP1(4), ENPP3(7), ENTPD7(1), EP400(5), G6PC(4), GANC(1), GBA3(4), GBE1(2), GCK(2), GYS1(1), GYS2(5), HK2(5), HK3(3), IFIH1(2), MGAM(47), MOV10L1(4), NUDT5(1), PGM1(1), PGM3(1), PYGL(3), PYGM(5), RAD54B(1), RUVBL2(2), SETX(1), SI(23), SKIV2L2(1), SMARCA2(4), UGP2(1), UGT1A1(1), UGT1A10(7), UGT1A3(3), UGT1A4(3), UGT1A5(4), UGT1A6(2), UGT1A7(5), UGT1A8(2), UGT1A9(5), UGT2A1(9), UGT2A3(5), UGT2B10(9), UGT2B11(7), UGT2B15(3), UGT2B28(8), UGT2B4(9), UGT2B7(5), UXS1(1)	5601066	269	31	266	100	192	27	9	19	21	1	0.000326	1.000	1.000
227	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(2), ACTG1(1), COL11A1(10), COL11A2(5), COL17A1(12), COL1A1(9), COL1A2(9), COL2A1(5), COL3A1(18), COL4A1(12), COL4A2(8), COL4A4(23), COL4A6(14), COL5A1(25), COL5A2(10), COL5A3(16), COL6A2(9), COL6A3(11), COL6A6(12), COMP(1), DES(1), DSC1(12), DSC2(9), DSC3(12), DSG1(19), DSG2(5), DSG4(17), FN1(5), GJA1(4), GJA10(5), GJA4(2), GJA5(2), GJA8(10), GJB1(1), GJB2(1), GJB3(1), GJB4(1), GJB5(5), GJC1(4), GJD2(2), IBSP(3), INA(1), ITGB4(4), KRT1(4), KRT10(1), KRT12(2), KRT13(1), KRT14(1), KRT15(4), KRT16(2), KRT17(3), KRT18(1), KRT2(8), KRT23(2), KRT24(2), KRT25(2), KRT27(2), KRT28(4), KRT3(7), KRT31(2), KRT32(4), KRT33A(2), KRT33B(1), KRT35(4), KRT36(3), KRT37(4), KRT38(2), KRT39(3), KRT4(5), KRT40(3), KRT5(2), KRT6A(5), KRT6B(2), KRT7(1), KRT71(6), KRT72(4), KRT73(5), KRT74(3), KRT75(2), KRT76(4), KRT77(2), KRT78(7), KRT8(1), KRT81(1), KRT82(3), KRT83(7), KRT84(3), KRT86(1), KRT9(6), LAMA1(15), LAMA2(22), LAMA3(23), LAMA4(2), LAMA5(10), LAMB1(5), LAMB2(5), LAMB3(7), LAMB4(12), LAMC1(3), LAMC2(6), LAMC3(2), LMNA(1), NES(7), PRPH(1), RELN(15), SPP1(2), THBS1(10), THBS2(2), THBS3(3), THBS4(4), TNC(12), TNN(11), TNR(20), TNXB(31), VIM(2), VTN(4), VWF(16)	11301463	735	31	723	322	557	52	19	58	49	0	0.00201	1.000	1.000
228	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(3), ABCA10(4), ABCA12(19), ABCA13(12), ABCA2(2), ABCA3(6), ABCA4(18), ABCA5(2), ABCA6(7), ABCA7(4), ABCA8(9), ABCA9(5), ABCB1(9), ABCB10(1), ABCB11(10), ABCB4(6), ABCB5(11), ABCB6(1), ABCB7(1), ABCB9(2), ABCC1(4), ABCC10(4), ABCC11(3), ABCC12(6), ABCC2(3), ABCC3(4), ABCC4(6), ABCC5(2), ABCC6(8), ABCC8(5), ABCC9(13), ABCD2(6), ABCD3(3), ABCG1(4), ABCG2(4), ABCG4(1), ABCG8(2), CFTR(14), TAP2(4)	5385770	228	31	226	129	144	23	14	21	26	0	0.105	1.000	1.000
229	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1B(1), ACVR2A(1), ACVR2B(1), BMP2(1), BMPR1B(2), BMPR2(1), CCL1(1), CCL2(1), CCL21(2), CCL24(1), CCL27(1), CCL7(3), CCL8(2), CCR1(3), CCR2(6), CCR3(3), CCR4(2), CCR5(4), CCR6(1), CCR8(1), CCR9(3), CD27(1), CD40(1), CD40LG(1), CSF1(3), CSF1R(3), CSF2RA(6), CSF2RB(3), CSF3(2), CSF3R(1), CX3CR1(3), CXCL12(1), CXCL5(1), CXCR3(1), CXCR4(1), CXCR6(1), EDA(1), EDA2R(1), EDAR(2), EGF(4), EGFR(6), EPO(2), EPOR(1), FAS(1), FASLG(2), FLT1(6), FLT3(7), FLT4(8), GDF5(3), GH1(1), GH2(3), GHR(7), HGF(4), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(1), IFNA21(2), IFNA4(1), IFNA5(1), IFNA8(1), IFNAR1(1), IFNB1(1), IFNGR1(2), IFNGR2(1), IL10(2), IL10RA(3), IL11RA(1), IL12B(1), IL12RB1(6), IL13RA1(2), IL15(1), IL15RA(2), IL17A(2), IL17B(2), IL17RA(3), IL17RB(1), IL18(2), IL18R1(6), IL18RAP(7), IL19(1), IL1A(3), IL1B(1), IL1R1(3), IL1R2(1), IL1RAP(2), IL2(1), IL20(3), IL20RA(3), IL21(1), IL21R(5), IL22RA1(2), IL25(1), IL26(1), IL28B(1), IL28RA(1), IL2RB(3), IL4(1), IL4R(3), IL5RA(7), IL6ST(1), IL7(2), IL7R(6), IL9(1), IL9R(1), INHBA(2), INHBB(2), INHBC(2), KDR(8), KIT(3), KITLG(1), LEP(1), LEPR(6), LIF(1), LIFR(5), LTA(1), MET(7), MPL(3), NGFR(5), OSM(3), OSMR(7), PDGFC(7), PDGFRA(9), PDGFRB(5), PLEKHO2(1), PPBP(1), PRLR(9), RELT(1), TGFBR2(2), TNFRSF10A(2), TNFRSF10C(1), TNFRSF10D(4), TNFRSF11A(1), TNFRSF11B(3), TNFRSF13B(1), TNFRSF14(2), TNFRSF17(1), TNFRSF19(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(3), TNFRSF4(2), TNFRSF8(1), TNFRSF9(2), TNFSF10(1), TNFSF11(1), TNFSF12(1), TNFSF14(4), TNFSF15(1), TNFSF18(3), TNFSF4(1), TNFSF8(2), TPO(11), VEGFA(2), VEGFC(7), XCR1(1)	8046304	393	31	389	224	272	24	12	42	43	0	0.375	1.000	1.000
230	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(1), CALML3(3), CDS1(2), CDS2(1), DGKB(6), DGKD(2), DGKE(1), DGKG(2), DGKH(6), DGKI(6), DGKZ(1), IMPA2(1), INPP1(1), INPP4B(1), INPP5A(2), INPP5B(2), INPP5D(13), INPPL1(7), ITPK1(2), ITPKB(2), ITPR1(8), ITPR2(4), ITPR3(1), OCRL(2), PI4KA(4), PI4KB(2), PIK3C2A(1), PIK3C2B(2), PIK3C2G(13), PIK3C3(1), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PIP4K2A(1), PIP4K2B(1), PIP5K1A(2), PIP5K1B(4), PIP5K1C(1), PLCB1(18), PLCB2(2), PLCB4(21), PLCD1(1), PLCE1(15), PLCG1(1), PLCG2(11), PLCZ1(7), PRKCA(5), PRKCG(4), PTEN(1), SYNJ1(9), SYNJ2(6)	5652725	227	31	223	112	172	15	7	14	18	1	0.0459	1.000	1.000
231	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	CPEB1(2), EGFR(6), ERBB2(4), ERBB4(13), ETS1(2), ETS2(2), ETV6(1), FMN2(20), KRAS(1), MAPK1(2), MAPK3(1), NOTCH1(1), NOTCH2(4), NOTCH3(5), NOTCH4(14), PIWIL1(3), PIWIL2(5), PIWIL3(4), PIWIL4(3), RAF1(3), SOS1(3), SOS2(5), SPIRE1(1), SPIRE2(2)	2327728	107	31	106	49	75	9	5	13	5	0	0.307	1.000	1.000
232	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	190	ACTB(2), ACTG1(1), ACTN1(1), ACTN2(6), ACTN3(3), AKT2(1), AKT3(2), ARHGAP5(3), BCAR1(2), BIRC3(1), CAPN2(1), CAV1(1), CCND1(1), CCND2(1), CDC42(1), COL11A1(10), COL11A2(5), COL1A1(9), COL1A2(9), COL2A1(5), COL3A1(18), COL4A1(12), COL4A2(8), COL4A4(23), COL4A6(14), COL5A1(25), COL5A2(10), COL5A3(16), COL6A2(9), COL6A3(11), COL6A6(12), COMP(1), CRK(1), CTNNB1(3), DIAPH1(5), DOCK1(5), EGF(4), EGFR(6), ELK1(1), ERBB2(4), FARP2(1), FLNA(5), FLNB(8), FLNC(20), FLT1(6), FN1(5), FYN(1), GRLF1(5), GSK3B(1), HGF(4), HRAS(2), IBSP(3), IGF1R(1), ITGA1(11), ITGA10(2), ITGA11(3), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(13), ITGA5(8), ITGA7(3), ITGA8(7), ITGA9(3), ITGAV(3), ITGB1(2), ITGB3(2), ITGB4(4), ITGB5(2), ITGB6(2), ITGB7(2), ITGB8(8), KDR(8), LAMA1(15), LAMA2(22), LAMA3(23), LAMA4(2), LAMA5(10), LAMB1(5), LAMB2(5), LAMB3(7), LAMB4(12), LAMC1(3), LAMC2(6), LAMC3(2), MAPK1(2), MAPK10(5), MAPK3(1), MAPK9(1), MET(7), MYL2(2), MYL5(1), MYL7(1), MYLK(11), MYLK2(2), MYLPF(1), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PAK7(15), PARVB(1), PARVG(1), PDGFC(7), PDGFD(2), PDGFRA(9), PDGFRB(5), PDPK1(2), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PIP5K1C(1), PPP1CB(3), PPP1CC(1), PPP1R12A(2), PRKCA(5), PRKCG(4), PTEN(1), PTK2(2), RAC2(1), RAF1(3), RAP1A(1), RAP1B(1), RAPGEF1(3), RELN(15), ROCK1(2), ROCK2(4), SHC1(1), SHC2(3), SHC3(1), SHC4(2), SOS1(3), SOS2(5), SPP1(2), SRC(1), THBS1(10), THBS2(2), THBS3(3), THBS4(4), TLN1(5), TLN2(6), TNC(12), TNN(11), TNR(20), TNXB(31), VASP(2), VAV1(2), VAV3(4), VCL(2), VEGFA(2), VEGFC(7), VTN(4), VWF(16), ZYX(2)	16851835	828	31	816	365	618	59	22	67	61	1	0.00150	1.000	1.000
233	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(2), CD36(2), CD44(1), COL11A1(10), COL11A2(5), COL1A1(9), COL1A2(9), COL2A1(5), COL3A1(18), COL4A1(12), COL4A2(8), COL4A4(23), COL4A6(14), COL5A1(25), COL5A2(10), COL5A3(16), COL6A2(9), COL6A3(11), COL6A6(12), DAG1(2), FN1(5), FNDC1(11), FNDC3A(1), FNDC4(1), FNDC5(1), GP5(1), GP6(2), GP9(1), HMMR(3), HSPG2(8), IBSP(3), ITGA1(11), ITGA10(2), ITGA11(3), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(13), ITGA5(8), ITGA7(3), ITGA8(7), ITGA9(3), ITGAV(3), ITGB1(2), ITGB3(2), ITGB4(4), ITGB5(2), ITGB6(2), ITGB7(2), ITGB8(8), LAMA1(15), LAMA2(22), LAMA3(23), LAMA4(2), LAMA5(10), LAMB1(5), LAMB2(5), LAMB3(7), LAMB4(12), LAMC1(3), LAMC2(6), LAMC3(2), RELN(15), SPP1(2), SV2A(7), SV2B(5), SV2C(6), THBS1(10), THBS2(2), THBS3(3), THBS4(4), TNC(12), TNN(11), TNR(20), TNXB(31), VTN(4), VWF(16)	10236254	579	31	572	234	450	29	17	47	36	0	0.00622	1.000	1.000
234	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	CADM1(2), CADM3(7), CD2(11), CD22(7), CD226(1), CD276(1), CD28(1), CD34(1), CD4(1), CD40(1), CD40LG(1), CD6(1), CD86(8), CD8B(1), CDH15(2), CDH2(2), CDH4(13), CDH5(4), CLDN1(1), CLDN10(1), CLDN11(3), CLDN14(1), CLDN16(1), CLDN17(1), CLDN18(3), CLDN2(2), CLDN20(1), CLDN4(3), CLDN6(1), CLDN7(1), CNTN1(5), CNTN2(3), CNTNAP1(3), CNTNAP2(29), CTLA4(1), HLA-A(2), HLA-B(2), HLA-DMA(1), HLA-DMB(3), HLA-DOA(1), HLA-DQA1(3), HLA-DQA2(4), HLA-DQB1(3), HLA-DRA(3), HLA-DRB1(2), HLA-DRB5(1), HLA-F(1), HLA-G(1), ICOS(1), ITGA4(13), ITGA8(7), ITGA9(3), ITGAL(8), ITGAM(9), ITGAV(3), ITGB1(2), ITGB2(6), ITGB7(2), ITGB8(8), JAM2(3), L1CAM(3), MAG(2), MPZ(1), MPZL1(1), NCAM1(3), NCAM2(2), NEO1(4), NFASC(10), NLGN1(2), NLGN2(1), NLGN3(1), NRCAM(4), NRXN1(11), NRXN2(2), NRXN3(8), OCLN(1), PTPRC(4), PTPRF(11), PTPRM(1), PVR(1), PVRL1(3), PVRL2(2), PVRL3(4), SELE(8), SELL(3), SELP(10), SELPLG(2), SIGLEC1(5), SPN(1), VCAM1(4), VCAN(15)	6677694	347	31	341	152	243	27	15	35	27	0	0.00276	1.000	1.000
235	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTB(2), ACTG1(1), ACTN1(1), ACTN2(6), ACTN3(3), AKT2(1), AKT3(2), AMOTL1(1), ASH1L(6), CDC42(1), CDK4(2), CGN(2), CLDN1(1), CLDN10(1), CLDN11(3), CLDN14(1), CLDN16(1), CLDN17(1), CLDN18(3), CLDN2(2), CLDN20(1), CLDN4(3), CLDN6(1), CLDN7(1), CSNK2A1(1), CTNNA1(2), CTNNA2(8), CTNNA3(13), CTNNB1(3), EPB41(3), EPB41L1(2), EPB41L2(4), EXOC4(3), GNAI2(4), HCLS1(3), HRAS(2), IGSF5(2), INADL(8), JAM2(3), KRAS(1), LLGL1(1), LLGL2(6), MAGI1(7), MAGI2(5), MLLT4(2), MPDZ(4), MYH1(29), MYH10(6), MYH11(11), MYH13(9), MYH14(5), MYH15(15), MYH2(22), MYH3(7), MYH4(27), MYH6(13), MYH7(10), MYH7B(3), MYH8(18), MYH9(1), MYL2(2), MYL5(1), MYL7(1), MYLPF(1), OCLN(1), PARD3(6), PARD6A(1), PARD6B(1), PARD6G(2), PPP2CB(1), PPP2R1B(2), PPP2R2A(2), PPP2R2B(1), PPP2R2C(2), PPP2R3A(3), PPP2R3B(2), PRKCA(5), PRKCD(2), PRKCE(2), PRKCG(4), PRKCH(2), PRKCI(2), PRKCQ(5), PRKCZ(1), PTEN(1), SPTAN1(2), SRC(1), SYMPK(1), TJP1(2), TJP2(4), TJP3(5), VAPA(1), ZAK(3)	8789398	382	31	373	246	269	37	12	31	32	1	0.573	1.000	1.000
236	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT2(1), AKT3(2), CBL(2), CBLB(5), CBLC(1), CCND1(1), CCND2(1), CREBBP(4), CSF2RA(6), CSF2RB(3), CSF3(2), CSF3R(1), EP300(7), EPO(2), EPOR(1), GH1(1), GH2(3), GHR(7), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(1), IFNA21(2), IFNA4(1), IFNA5(1), IFNA8(1), IFNAR1(1), IFNB1(1), IFNGR1(2), IFNGR2(1), IL10(2), IL10RA(3), IL11RA(1), IL12B(1), IL12RB1(6), IL13RA1(2), IL13RA2(1), IL15(1), IL15RA(2), IL19(1), IL2(1), IL20(3), IL20RA(3), IL21(1), IL21R(5), IL22RA1(2), IL26(1), IL28B(1), IL28RA(1), IL2RB(3), IL4(1), IL4R(3), IL5RA(7), IL6ST(1), IL7(2), IL7R(6), IL9(1), IL9R(1), JAK1(1), JAK2(1), LEP(1), LEPR(6), LIF(1), LIFR(5), MPL(3), MYC(2), OSM(3), OSMR(7), PIAS2(1), PIAS3(3), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PRLR(9), PTPN11(5), SOCS4(2), SOCS5(1), SOCS7(3), SOS1(3), SOS2(5), SPRED1(2), SPRY1(1), SPRY3(3), STAT1(3), STAT3(1), STAT4(7), STAT5A(1), STAT5B(1), STAT6(4), TPO(11), TYK2(3)	6634934	243	31	239	122	158	21	9	27	28	0	0.328	1.000	1.000
237	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(7), AMY2A(2), AMY2B(2), ENPP1(4), ENPP3(7), G6PC(4), GBA3(4), GBE1(2), GCK(2), GYS1(1), GYS2(5), HK2(5), HK3(3), MGAM(47), PGM1(1), PGM3(1), PYGL(3), PYGM(5), SI(23), UCHL1(2), UCHL3(1), UGT1A1(1), UGT1A10(7), UGT1A3(3), UGT1A4(3), UGT1A5(4), UGT1A6(2), UGT1A7(5), UGT1A8(2), UGT1A9(5), UGT2B15(3), UGT2B4(9), UXS1(1)	2587485	176	31	172	67	127	20	5	12	11	1	0.00278	1.000	1.000
238	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(6), ADCY2(1), ADCY3(1), ADCY4(1), ADCY5(5), ADCY6(1), ADCY7(2), ADCY8(17), ADCY9(1), ADRA1A(2), ADRA1B(2), ADRA1D(1), ADRB1(3), ANXA6(2), ARRB2(3), ATP1A4(1), ATP2A2(4), ATP2A3(4), ATP2B1(4), ATP2B2(6), ATP2B3(2), CACNA1A(7), CACNA1B(6), CACNA1C(8), CACNA1D(8), CACNA1E(31), CACNA1S(13), CACNB1(3), CACNB3(1), CALM1(1), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CAMK4(3), CASQ2(2), CHRM1(2), CHRM2(8), CHRM3(4), CHRM4(2), CHRM5(2), GJA1(4), GJA4(2), GJA5(2), GJB1(1), GJB2(1), GJB3(1), GJB4(1), GJB5(5), GNA11(1), GNAI2(4), GNAQ(1), GNAZ(3), GNB3(2), GNB4(3), GNB5(1), GNG2(1), GRK4(2), GRK5(2), ITPR1(8), ITPR2(4), ITPR3(1), KCNB1(10), KCNJ3(8), KCNJ5(3), MIB1(3), NME7(2), PKIG(1), PRKACA(1), PRKACB(1), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(2), PRKCG(4), PRKCH(2), PRKCQ(5), PRKCZ(1), PRKD1(1), RGS11(1), RGS18(3), RGS3(3), RGS4(1), RGS6(7), RGS7(8), RGS9(3), RYR1(18), RYR2(22), RYR3(22), SFN(1), SLC8A1(12), SLC8A3(7), USP5(2), YWHAQ(2)	8507182	392	30	386	291	268	44	20	31	29	0	0.837	1.000	1.000
239	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY1(6), ADCY2(1), ADCY3(1), ADCY4(1), ADCY5(5), ADCY6(1), ADCY7(2), ADCY8(17), ADCY9(1), AKAP1(2), AKAP10(1), AKAP11(3), AKAP12(1), AKAP3(5), AKAP4(5), AKAP6(10), AKAP7(1), AKAP8(1), AKAP9(9), ARHGEF1(1), CALM1(1), GNA11(1), GNA12(1), GNA14(1), GNA15(2), GNAI2(4), GNAQ(1), GNAZ(3), GNB3(2), GNB5(1), GNGT2(2), HRAS(2), ITPR1(8), KCNJ3(8), KRAS(1), PDE1A(10), PDE1B(1), PDE1C(13), PDE4A(2), PDE4B(2), PDE4C(2), PDE4D(1), PDE7B(4), PDE8B(10), PRKACA(1), PRKACB(1), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(2), PRKCG(4), PRKCH(2), PRKCI(2), PRKCQ(5), PRKCZ(1), PRKD1(1), SLC9A1(1), USP5(2)	5317707	189	30	185	130	135	19	9	15	11	0	0.866	1.000	1.000
240	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA1(1), ADORA3(4), ADRA1A(2), ADRA1B(2), ADRA1D(1), ADRA2A(1), ADRB1(3), AGTR1(2), AGTR2(1), AVPR1A(3), AVPR1B(3), BDKRB1(1), BDKRB2(3), BRS3(1), CCBP2(3), CCKAR(4), CCKBR(2), CCR1(3), CCR10(1), CCR2(6), CCR3(3), CCR4(2), CCR5(4), CCR6(1), CCR8(1), CCR9(3), CCRL2(1), CHML(1), CHRM1(2), CHRM2(8), CHRM3(4), CHRM4(2), CHRM5(2), CMKLR1(5), CNR1(1), CNR2(3), CX3CR1(3), CXCR3(1), CXCR4(1), DRD1(1), DRD2(2), DRD3(3), DRD4(1), DRD5(6), EDNRA(3), F2R(2), F2RL1(2), F2RL2(3), F2RL3(1), FPR1(4), FSHR(3), GALR3(1), GALT(1), GHSR(1), GNB2L1(1), GPR17(1), GPR174(4), GPR3(1), GPR35(1), GPR37(3), GPR37L1(1), GPR4(3), GPR50(5), GPR6(3), GPR63(2), GPR77(3), GPR83(5), GPR85(1), GPR87(1), GRPR(1), HCRTR1(1), HCRTR2(10), HRH1(4), HRH3(3), HTR1A(2), HTR1D(3), HTR1E(1), HTR1F(5), HTR2A(2), HTR2B(2), HTR2C(3), HTR4(5), HTR5A(5), HTR6(1), HTR7(3), LHCGR(9), MAS1(2), MC3R(2), MC5R(1), MTNR1A(2), NMBR(1), NMUR2(6), NPY1R(6), NPY2R(3), NPY5R(2), NTSR1(2), OPN3(1), OPRL1(2), OR10A5(1), OR11A1(1), OR1C1(2), OR1Q1(2), OR2H1(2), OR5V1(4), OR7C1(1), OR8B8(4), OXTR(2), P2RY1(1), P2RY10(3), P2RY12(2), P2RY14(1), P2RY2(5), PPYR1(5), PTAFR(1), PTGDR(2), PTGER2(1), PTGFR(6), PTGIR(1), RGR(1), RRH(1), SSTR1(2), SSTR2(2), SSTR3(2), SSTR4(1), SUCNR1(2), TBXA2R(2), TRHR(3)	5479543	317	30	315	238	222	28	7	36	24	0	0.0724	1.000	1.000
241	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(6), ADCY2(1), ADCY3(1), ADCY4(1), ADCY5(5), ADCY6(1), ADCY7(2), ADCY8(17), ADCY9(1), ADK(1), ADSSL1(1), AK2(2), AK5(1), AK7(7), ALLC(2), AMPD1(7), AMPD3(2), ATIC(2), CANT1(4), DGUOK(2), ENPP1(4), ENPP3(7), ENTPD1(2), ENTPD2(1), ENTPD4(1), ENTPD6(1), GART(2), GDA(4), GMPS(1), GUCY1A2(6), GUCY1A3(10), GUCY1B3(1), GUCY2C(10), GUCY2D(4), GUCY2F(7), NME6(2), NME7(2), NPR1(1), NPR2(2), NT5C1A(2), NT5C1B(6), NT5C3(2), NT5E(1), NT5M(1), NUDT5(1), NUDT9(1), PAICS(1), PAPSS2(2), PDE10A(2), PDE11A(4), PDE1A(10), PDE1C(13), PDE2A(1), PDE3B(1), PDE4A(2), PDE4B(2), PDE4C(2), PDE4D(1), PDE5A(3), PDE7B(4), PDE8B(10), PDE9A(3), PFAS(2), PKLR(4), PKM2(1), POLA2(2), POLD1(1), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLR1A(5), POLR1B(4), POLR2A(1), POLR2B(6), POLR2E(1), POLR3A(2), POLR3B(4), POLR3G(1), POLR3GL(1), PRIM2(3), PRPS1L1(4), PRPS2(1), PRUNE(1), RRM1(1), XDH(13)	7452669	277	30	272	139	188	19	17	31	22	0	0.0735	1.000	1.000
242	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH5(1), ADH6(2), ADH7(1), ADHFE1(2), AKR1C2(1), AKR1C3(3), AKR1C4(4), ALDH1A3(1), ALDH3A1(2), ALDH3B1(1), ALDH3B2(2), CYP1A1(2), CYP1A2(2), CYP1B1(1), CYP2B6(5), CYP2C18(10), CYP2C19(7), CYP2C8(11), CYP2C9(12), CYP2E1(5), CYP2F1(3), CYP2S1(2), CYP3A4(3), CYP3A43(4), CYP3A5(2), CYP3A7(7), DHDH(2), EPHX1(1), GSTA1(2), GSTA2(2), GSTA5(1), GSTK1(1), GSTM2(2), GSTM3(2), GSTM4(2), GSTM5(1), MGST1(1), MGST2(1), UGT1A1(1), UGT1A10(7), UGT1A3(3), UGT1A4(3), UGT1A5(4), UGT1A6(2), UGT1A7(5), UGT1A8(2), UGT1A9(5), UGT2A1(9), UGT2A3(5), UGT2B10(9), UGT2B11(7), UGT2B15(3), UGT2B28(8), UGT2B4(9), UGT2B7(5)	2596722	229	30	224	90	162	20	10	15	21	1	0.000197	1.000	1.000
243	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	ALG10(1), ALG10B(1), ALG13(2), ALG2(2), ALG3(1), ALG6(1), B3GNT7(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), C1GALT1(1), C1GALT1C1(1), CHST1(2), CHST11(2), CHST12(2), CHST13(1), CHST2(3), CHST4(3), CHST6(2), CHSY1(6), DAD1(1), EXT1(1), EXT2(1), EXTL3(3), FUT8(2), GALNT1(1), GALNT11(1), GALNT12(1), GALNT13(8), GALNT14(8), GALNT2(1), GALNT3(1), GALNT4(2), GALNT5(3), GALNT6(4), GALNT7(2), GALNT8(5), GALNT9(1), GALNTL1(2), GALNTL2(10), GALNTL4(3), GALNTL5(2), GCNT1(2), GCNT4(3), HS2ST1(1), HS3ST1(4), HS3ST2(1), HS3ST3A1(2), HS3ST5(3), HS6ST1(1), HS6ST2(1), HS6ST3(2), MAN1A1(3), MAN1B1(1), MAN1C1(3), MGAT1(1), MGAT3(4), MGAT4A(2), MGAT5(1), MGAT5B(3), NDST1(1), NDST2(1), NDST3(7), NDST4(12), OGT(2), RPN2(1), ST3GAL1(2), ST6GAL1(1), ST6GALNAC1(1), STT3B(1), WBSCR17(11), XYLT1(5)	4978490	181	30	179	110	125	18	11	17	10	0	0.620	1.000	1.000
244	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	242	ACVR1B(1), AKT2(1), AKT3(2), ARRB2(3), ATF2(1), ATF4(2), BDNF(1), CACNA1A(7), CACNA1B(6), CACNA1C(8), CACNA1D(8), CACNA1E(31), CACNA1F(7), CACNA1G(10), CACNA1H(5), CACNA1I(7), CACNA1S(13), CACNA2D1(3), CACNA2D2(5), CACNA2D3(14), CACNA2D4(6), CACNB1(3), CACNB2(4), CACNB3(1), CACNB4(4), CACNG1(2), CACNG2(3), CACNG3(4), CACNG4(1), CACNG5(1), CACNG6(2), CACNG7(1), CDC25B(1), CDC42(1), CHP(1), CHUK(1), CRK(1), DAXX(5), DDIT3(1), DUSP10(3), DUSP14(1), DUSP16(2), DUSP5(2), DUSP7(1), DUSP9(2), EGF(4), EGFR(6), ELK1(1), ELK4(2), FAS(1), FASLG(2), FGF12(3), FGF13(2), FGF14(2), FGF16(2), FGF21(2), FGF23(2), FGF3(3), FGF4(1), FGF5(2), FGF6(2), FGF8(1), FGF9(2), FGFR1(4), FGFR2(7), FGFR3(2), FLNA(5), FLNB(8), FLNC(20), GNA12(1), HRAS(2), IL1A(3), IL1B(1), IL1R1(3), IL1R2(1), KRAS(1), MAP2K3(2), MAP2K5(1), MAP2K7(2), MAP3K10(2), MAP3K12(1), MAP3K13(2), MAP3K14(2), MAP3K2(1), MAP3K3(1), MAP3K4(4), MAP3K5(7), MAP3K6(1), MAP3K7(1), MAP4K1(4), MAP4K3(1), MAP4K4(4), MAPK1(2), MAPK10(5), MAPK13(1), MAPK14(3), MAPK3(1), MAPK7(2), MAPK8IP2(3), MAPK8IP3(3), MAPK9(1), MAPKAPK2(2), MAPKAPK3(1), MAPT(3), MEF2C(1), MKNK1(1), MYC(2), NFATC2(1), NFATC4(6), NFKB1(4), NLK(2), NTF3(1), NTRK1(2), NTRK2(5), PAK2(2), PDGFRA(9), PDGFRB(5), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), PPM1A(2), PPM1B(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKCA(5), PRKCG(4), PTPN5(4), PTPRR(5), RAC2(1), RAF1(3), RAP1A(1), RAP1B(1), RAPGEF2(3), RASA2(6), RASGRF1(4), RASGRF2(9), RASGRP1(2), RASGRP2(2), RASGRP3(3), RASGRP4(4), RPS6KA1(3), RPS6KA5(1), RPS6KA6(3), SOS1(3), SOS2(5), STMN1(2), TAOK1(4), TAOK2(6), TGFBR2(2), TNFRSF1A(1), TRAF6(2), ZAK(3)	12500344	506	30	501	310	340	56	21	43	46	0	0.539	1.000	1.000
245	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(6), ADCY2(1), ADCY3(1), ADCY4(1), ADCY7(2), ADCY8(17), ADCY9(1), ADRA1A(2), ADRA1B(2), ADRA1D(1), ADRB1(3), AGTR1(2), ATP2A1(3), ATP2A2(4), ATP2A3(4), ATP2B1(4), ATP2B2(6), ATP2B3(2), ATP2B4(6), AVPR1A(3), AVPR1B(3), BDKRB1(1), BDKRB2(3), BST1(1), CACNA1A(7), CACNA1B(6), CACNA1C(8), CACNA1D(8), CACNA1E(31), CACNA1F(7), CACNA1G(10), CACNA1H(5), CACNA1I(7), CACNA1S(13), CALM1(1), CALML3(3), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CAMK4(3), CCKAR(4), CCKBR(2), CHP(1), CHRM1(2), CHRM2(8), CHRM3(4), CHRM5(2), CYSLTR2(1), DRD1(1), EDNRA(3), EGFR(6), ERBB2(4), ERBB3(1), ERBB4(13), F2R(2), GNA11(1), GNA14(1), GNA15(2), GNAQ(1), GNAS(4), GRIN1(3), GRIN2A(30), GRIN2C(2), GRIN2D(2), GRM1(7), GRM5(4), GRPR(1), HRH1(4), HTR2A(2), HTR2B(2), HTR2C(3), HTR4(5), HTR5A(5), HTR6(1), HTR7(3), ITPKB(2), ITPR1(8), ITPR2(4), ITPR3(1), LHCGR(9), MYLK(11), MYLK2(2), NOS1(20), NOS3(2), NTSR1(2), OXTR(2), P2RX1(2), P2RX3(2), P2RX4(1), P2RX5(2), PDE1A(10), PDE1B(1), PDE1C(13), PDGFRA(9), PDGFRB(5), PHKA1(8), PHKA2(2), PHKB(1), PHKG2(1), PLCB1(18), PLCB2(2), PLCB4(21), PLCD1(1), PLCE1(15), PLCG1(1), PLCG2(11), PLCZ1(7), PPP3R2(1), PRKACA(1), PRKACB(1), PRKCA(5), PRKCG(4), PTAFR(1), PTGER3(1), PTGFR(6), PTK2B(2), RYR1(18), RYR2(22), RYR3(22), SLC8A1(12), SLC8A2(3), SLC8A3(7), SPHK2(3), TACR1(1), TACR2(2), TACR3(6), TBXA2R(2), TNNC1(1), TNNC2(1), TRHR(3), TRPC1(1), VDAC1(1), VDAC3(1)	12173612	655	30	644	462	480	48	22	52	52	1	0.507	1.000	1.000
246	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	234	ADCYAP1R1(3), ADORA1(1), ADORA3(4), ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2B(1), ADRB1(3), AGTR1(2), AGTR2(1), AVPR1A(3), AVPR1B(3), BDKRB1(1), BDKRB2(3), BRS3(1), C5AR1(2), CALCR(6), CALCRL(6), CCKAR(4), CCKBR(2), CHRM1(2), CHRM2(8), CHRM3(4), CHRM4(2), CHRM5(2), CNR1(1), CNR2(3), CRHR1(2), CRHR2(1), CTSG(1), CYSLTR2(1), DRD1(1), DRD2(2), DRD3(3), DRD4(1), DRD5(6), EDNRA(3), F2(3), F2R(2), F2RL1(2), F2RL2(3), F2RL3(1), FPR1(4), FSHR(3), GABBR1(3), GABBR2(1), GABRA1(6), GABRA2(4), GABRA3(6), GABRA4(3), GABRA5(1), GABRA6(8), GABRB1(5), GABRB2(5), GABRB3(6), GABRD(2), GABRE(5), GABRG1(8), GABRG2(2), GABRG3(2), GABRP(5), GABRQ(3), GABRR2(1), GALR3(1), GH1(1), GH2(3), GHR(7), GHSR(1), GIPR(1), GLP1R(3), GLP2R(7), GLRA1(1), GLRA3(8), GPR156(4), GPR35(1), GPR50(5), GPR63(2), GPR83(5), GRIA1(13), GRIA2(5), GRIA3(10), GRIA4(6), GRID1(8), GRID2(16), GRIK1(4), GRIK2(6), GRIK3(6), GRIK4(2), GRIK5(3), GRIN1(3), GRIN2A(30), GRIN2B(11), GRIN2C(2), GRIN2D(2), GRIN3A(13), GRIN3B(1), GRM1(7), GRM2(3), GRM3(18), GRM4(8), GRM5(4), GRM6(11), GRM7(9), GRM8(12), GRPR(1), GZMA(5), HCRTR1(1), HCRTR2(10), HRH1(4), HRH3(3), HRH4(1), HTR1A(2), HTR1D(3), HTR1E(1), HTR1F(5), HTR2A(2), HTR2B(2), HTR2C(3), HTR4(5), HTR5A(5), HTR6(1), HTR7(3), LEP(1), LEPR(6), LHCGR(9), MAS1(2), MC2R(4), MC3R(2), MC5R(1), MCHR2(3), MTNR1A(2), NMBR(1), NMUR2(6), NPBWR2(3), NPFFR2(3), NPY1R(6), NPY2R(3), NPY5R(2), NR3C1(3), NTSR1(2), OPRL1(2), OXTR(2), P2RX1(2), P2RX3(2), P2RX4(1), P2RX5(2), P2RY1(1), P2RY10(3), P2RY14(1), P2RY2(5), P2RY8(1), PARD3(6), PPYR1(5), PRLR(9), PRSS1(6), PRSS3(1), PTAFR(1), PTGDR(2), PTGER2(1), PTGER3(1), PTGFR(6), PTGIR(1), PTH2R(4), RXFP1(5), RXFP2(3), SCTR(3), SSTR1(2), SSTR2(2), SSTR3(2), SSTR4(1), TAAR1(2), TAAR2(3), TAAR6(6), TAAR8(2), TAAR9(1), TACR1(1), TACR2(2), TACR3(6), TBXA2R(2), THRB(4), TRHR(3), TRPV1(2), TSHB(3), TSHR(1), VIPR1(1), VIPR2(3)	9945071	692	30	671	423	498	55	25	57	56	1	0.000500	1.000	1.000
247	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	142	APC(5), APC2(3), AXIN1(4), AXIN2(2), BTRC(3), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CCND1(1), CCND2(1), CER1(6), CHD8(4), CHP(1), CREBBP(4), CSNK1A1L(1), CSNK1E(1), CSNK2A1(1), CTNNB1(3), CUL1(2), CXXC4(1), DAAM1(1), DAAM2(1), DKK2(4), DKK4(1), DVL3(1), EP300(7), FBXW11(2), FZD1(1), FZD10(1), FZD2(2), FZD4(1), FZD6(1), FZD7(3), GSK3B(1), LEF1(1), LRP5(7), LRP6(2), MAP3K7(1), MAPK10(5), MAPK9(1), MMP7(1), MYC(2), NFAT5(2), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), NKD1(1), NKD2(1), NLK(2), PLCB1(18), PLCB2(2), PLCB4(21), PPARD(1), PPP2CB(1), PPP2R1B(2), PPP2R2A(2), PPP2R2B(1), PPP2R2C(2), PPP3R2(1), PRICKLE1(2), PRICKLE2(1), PRKACA(1), PRKACB(1), PRKCA(5), PRKCG(4), RAC2(1), ROCK1(2), ROCK2(4), RUVBL1(1), SENP2(3), SFRP1(1), SFRP2(3), SFRP4(1), SMAD2(1), SMAD3(1), SOX17(4), TBL1X(1), TBL1XR1(1), TBL1Y(2), TCF7L1(1), VANGL1(2), VANGL2(1), WIF1(4), WNT10A(3), WNT10B(1), WNT11(1), WNT2(2), WNT3(1), WNT3A(2), WNT4(2), WNT5A(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(3), WNT9B(2)	7285616	240	30	238	112	166	19	13	23	18	1	0.0746	1.000	1.000
248	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	124	ABL1(1), ABLIM1(4), ABLIM2(2), ABLIM3(2), ARHGEF12(4), CDC42(1), CHP(1), CXCL12(1), CXCR4(1), DCC(28), DPYSL5(2), EFNA2(1), EFNA5(1), EFNB3(1), EPHA1(3), EPHA2(5), EPHA3(8), EPHA4(5), EPHA5(2), EPHA7(17), EPHA8(4), EPHB1(8), EPHB2(8), EPHB3(5), EPHB4(5), EPHB6(4), FES(1), FYN(1), GNAI2(4), GSK3B(1), HRAS(2), ITGB1(2), KRAS(1), L1CAM(3), LIMK1(1), LIMK2(1), LRRC4C(10), MAPK1(2), MAPK3(1), MET(7), NCK2(1), NFAT5(2), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), NGEF(4), NRP1(4), NTN4(4), NTNG1(4), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PAK7(15), PLXNA1(6), PLXNA2(2), PLXNB1(4), PLXNB2(6), PLXNB3(1), PLXNC1(3), PPP3R2(1), PTK2(2), RAC2(1), RGS3(3), RHOD(1), RND1(1), ROBO1(3), ROBO2(7), ROBO3(5), ROCK1(2), ROCK2(4), SEMA3A(3), SEMA3B(2), SEMA3D(6), SEMA3E(5), SEMA3F(1), SEMA3G(4), SEMA4A(1), SEMA4B(1), SEMA4C(3), SEMA4D(3), SEMA4F(2), SEMA4G(1), SEMA5A(6), SEMA5B(2), SEMA6A(2), SEMA6B(2), SEMA6C(2), SEMA6D(1), SEMA7A(2), SLIT1(5), SLIT2(11), SLIT3(15), SRGAP1(4), SRGAP2(2), SRGAP3(10), UNC5A(4), UNC5B(7), UNC5C(3), UNC5D(7)	8776572	387	30	379	214	269	28	11	40	39	0	0.234	1.000	1.000
249	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	91	ADCY1(6), ADCY2(1), ADCY3(1), ADCY4(1), ADCY5(5), ADCY6(1), ADCY7(2), ADCY8(17), ADCY9(1), ADRB1(3), DRD1(1), DRD2(2), EGF(4), EGFR(6), GJA1(4), GJD2(2), GNA11(1), GNAI2(4), GNAQ(1), GNAS(4), GRM1(7), GRM5(4), GUCY1A2(6), GUCY1A3(10), GUCY1B3(1), GUCY2C(10), GUCY2D(4), GUCY2F(7), HRAS(2), HTR2A(2), HTR2B(2), HTR2C(3), ITPR1(8), ITPR2(4), ITPR3(1), KRAS(1), MAP2K5(1), MAP3K2(1), MAPK1(2), MAPK3(1), MAPK7(2), NPR1(1), NPR2(2), PDGFC(7), PDGFD(2), PDGFRA(9), PDGFRB(5), PLCB1(18), PLCB2(2), PLCB4(21), PRKACA(1), PRKACB(1), PRKCA(5), PRKCG(4), PRKG1(7), PRKG2(4), RAF1(3), SOS1(3), SOS2(5), SRC(1), TJP1(2), TUBA1A(1), TUBA3C(7), TUBA3D(3), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB1(2), TUBB2A(1), TUBB4(2), TUBB6(4), TUBB8(5)	5983411	279	30	276	167	188	29	11	32	18	1	0.296	1.000	1.000
250	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	65	A2M(5), BDKRB1(1), BDKRB2(3), C1QC(3), C1R(2), C1S(3), C2(2), C3(14), C4BPA(4), C4BPB(1), C5(2), C5AR1(2), C6(18), C8B(11), C9(5), CD55(1), CFB(7), CFH(22), CFI(2), CR1(13), CR2(10), F10(2), F11(2), F13A1(3), F13B(6), F2(3), F2R(2), F5(9), F7(2), F8(12), F9(3), FGA(11), FGG(2), KLKB1(7), KNG1(4), MASP1(2), MASP2(3), MBL2(1), PLAT(1), PLG(11), PROC(1), PROS1(4), SERPINA1(1), SERPINA5(4), SERPINC1(1), SERPINE1(2), SERPINF2(1), TFPI(4), VWF(16)	3996926	251	30	248	109	178	23	7	22	21	0	0.0475	1.000	1.000
251	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	97	AKT2(1), AKT3(2), CASP8(1), CD40(1), CD86(8), CHUK(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(1), IFNA21(2), IFNA4(1), IFNA5(1), IFNA8(1), IFNAR1(1), IFNB1(1), IKBKE(1), IL12B(1), IL1B(1), IRAK4(1), IRF3(1), IRF5(2), IRF7(2), LBP(1), MAP2K3(2), MAP2K7(2), MAP3K7(1), MAPK1(2), MAPK10(5), MAPK13(1), MAPK14(3), MAPK3(1), MAPK9(1), MYD88(2), NFKB1(4), NFKBIA(1), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), RELA(1), SPP1(2), STAT1(3), TBK1(2), TICAM1(4), TLR1(4), TLR2(4), TLR3(3), TLR4(8), TLR5(5), TLR7(4), TLR8(3), TLR9(3), TRAF3(3), TRAF6(2)	4063020	128	30	128	70	92	11	6	11	8	0	0.328	1.000	1.000
252	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	91	AKT2(1), AKT3(2), BCL10(1), CARD11(9), CBL(2), CBLB(5), CBLC(1), CD28(1), CD3D(2), CD4(1), CD40LG(1), CD8B(1), CDC42(1), CDK4(2), CHP(1), CHUK(1), CTLA4(1), FYN(1), GRAP2(1), HRAS(2), ICOS(1), IL10(2), IL2(1), IL4(1), ITK(8), KRAS(1), LCK(3), LCP2(3), MALT1(3), MAP3K14(2), NCK2(1), NFAT5(2), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), NFKB1(4), NFKBIA(1), NFKBIB(1), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PAK7(15), PDK1(1), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PLCG1(1), PPP3R2(1), PRKCQ(5), PTPRC(4), RASGRP1(2), SOS1(3), SOS2(5), TEC(2), VAV1(2), VAV3(4), ZAP70(2)	4613778	158	30	156	84	113	13	6	13	13	0	0.435	1.000	1.000
253	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN1(1), ACTN2(6), ACTN3(3), ARHGAP5(3), BCAR1(2), CDC42(1), CDH5(4), CLDN1(1), CLDN10(1), CLDN11(3), CLDN14(1), CLDN16(1), CLDN17(1), CLDN18(3), CLDN2(2), CLDN20(1), CLDN4(3), CLDN6(1), CLDN7(1), CTNNA1(2), CTNNA2(8), CTNNA3(13), CTNNB1(3), CTNND1(4), CXCL12(1), CXCR4(1), CYBB(5), GNAI2(4), GRLF1(5), ITGA4(13), ITGAL(8), ITGAM(9), ITGB1(2), ITGB2(6), ITK(8), JAM2(3), MAPK13(1), MAPK14(3), MLLT4(2), MMP2(3), MMP9(4), MSN(1), MYL2(2), MYL5(1), MYL7(1), MYLPF(1), NCF2(2), NCF4(2), NOX1(3), NOX3(1), OCLN(1), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PLCG1(1), PLCG2(11), PRKCA(5), PRKCG(4), PTK2(2), PTK2B(2), PTPN11(5), RAC2(1), RAP1A(1), RAP1B(1), RAPGEF3(1), RAPGEF4(3), RASSF5(2), ROCK1(2), ROCK2(4), SIPA1(3), THY1(1), TXK(5), VASP(2), VAV1(2), VAV3(4), VCAM1(4), VCL(2)	5614806	247	30	241	102	174	22	9	19	22	1	0.000291	1.000	1.000
254	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	65	ADCY1(6), ADCY8(17), ATF4(2), CACNA1C(8), CALM1(1), CALML3(3), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CAMK4(3), CHP(1), CREBBP(4), EP300(7), GNAQ(1), GRIA1(13), GRIA2(5), GRIN1(3), GRIN2A(30), GRIN2B(11), GRIN2C(2), GRIN2D(2), GRM1(7), GRM5(4), HRAS(2), ITPR1(8), ITPR2(4), ITPR3(1), KRAS(1), MAPK1(2), MAPK3(1), PLCB1(18), PLCB2(2), PLCB4(21), PPP1CB(3), PPP1CC(1), PPP1R12A(2), PPP1R1A(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKCA(5), PRKCG(4), RAF1(3), RAP1A(1), RAP1B(1), RAPGEF3(1), RPS6KA1(3), RPS6KA6(3)	4402852	227	30	222	142	171	17	6	18	14	1	0.471	1.000	1.000
255	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	200	ACTN1(1), ACTN2(6), ACTN3(3), APC(5), APC2(3), ARHGEF1(1), ARHGEF12(4), ARPC5(1), BAIAP2(2), BCAR1(2), BDKRB1(1), BDKRB2(3), CDC42(1), CHRM1(2), CHRM2(8), CHRM3(4), CHRM4(2), CHRM5(2), CRK(1), CYFIP2(8), DIAPH1(5), DIAPH2(1), DIAPH3(4), DOCK1(5), EGF(4), EGFR(6), F2(3), F2R(2), FGD1(2), FGD3(3), FGF12(3), FGF13(2), FGF14(2), FGF16(2), FGF21(2), FGF23(2), FGF3(3), FGF4(1), FGF5(2), FGF6(2), FGF8(1), FGF9(2), FGFR1(4), FGFR2(7), FGFR3(2), FN1(5), GNA12(1), GRLF1(5), GSN(2), HRAS(2), IQGAP1(4), IQGAP2(3), IQGAP3(2), ITGA1(11), ITGA10(2), ITGA11(3), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(13), ITGA5(8), ITGA7(3), ITGA8(7), ITGA9(3), ITGAD(6), ITGAE(6), ITGAL(8), ITGAM(9), ITGAV(3), ITGAX(5), ITGB1(2), ITGB2(6), ITGB3(2), ITGB4(4), ITGB5(2), ITGB6(2), ITGB7(2), ITGB8(8), KRAS(1), LIMK1(1), LIMK2(1), MAPK1(2), MAPK3(1), MSN(1), MYH10(6), MYH14(5), MYH9(1), MYL2(2), MYL5(1), MYL7(1), MYLK(11), MYLK2(2), MYLPF(1), NCKAP1(1), NCKAP1L(5), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PAK7(15), PDGFRA(9), PDGFRB(5), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PIP4K2A(1), PIP4K2B(1), PIP5K1A(2), PIP5K1B(4), PIP5K1C(1), PPP1CB(3), PPP1CC(1), PPP1R12A(2), PPP1R12B(3), PTK2(2), RAC2(1), RAF1(3), ROCK1(2), ROCK2(4), SCIN(4), SLC9A1(1), SOS1(3), SOS2(5), SSH1(3), SSH2(4), TIAM1(3), TIAM2(6), VAV1(2), VAV3(4), VCL(2), WAS(2), WASL(4)	12455000	446	30	441	238	310	32	13	48	42	1	0.110	1.000	1.000
256	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(6), ACACB(5), AKT2(1), AKT3(2), CALM1(1), CALML3(3), CBL(2), CBLB(5), CBLC(1), CRK(1), ELK1(1), EXOC7(2), FASN(5), FBP1(1), FLOT1(1), FOXO1(3), G6PC(4), GCK(2), GSK3B(1), GYS1(1), GYS2(5), HRAS(2), INPP5D(13), INSR(3), IRS2(1), IRS4(3), KRAS(1), LIPE(1), MAPK1(2), MAPK10(5), MAPK3(1), MAPK9(1), MKNK1(1), PCK1(8), PDE3A(7), PDE3B(1), PDPK1(2), PFKL(2), PHKA1(8), PHKA2(2), PHKB(1), PHKG2(1), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PKLR(4), PKM2(1), PPARGC1A(3), PPP1CB(3), PPP1CC(1), PPP1R3A(23), PPP1R3B(1), PPP1R3C(1), PPP1R3D(1), PRKAA1(1), PRKAA2(4), PRKAB1(1), PRKACA(1), PRKACB(1), PRKAG1(1), PRKAG2(4), PRKAG3(5), PRKAR2B(3), PRKCI(2), PRKCZ(1), PTPN1(1), PTPRF(11), PYGL(3), PYGM(5), RAF1(3), RAPGEF1(3), RPS6KB1(1), RPS6KB2(1), SHC1(1), SHC2(3), SHC3(1), SHC4(2), SLC2A4(4), SOCS4(2), SORBS1(2), SOS1(3), SOS2(5), SREBF1(3), TRIP10(2), TSC1(1), TSC2(3)	7208132	258	30	256	130	182	21	11	21	23	0	0.125	1.000	1.000
257	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY1(6), ADCY2(1), ADCY3(1), ADCY4(1), ADCY5(5), ADCY6(1), ADCY7(2), ADCY8(17), ADCY9(1), ASIP(1), CALM1(1), CALML3(3), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CREB3(1), CREB3L1(3), CREB3L2(2), CREB3L3(6), CREB3L4(2), CREBBP(4), CTNNB1(3), DCT(1), DVL3(1), EDN1(2), EP300(7), FZD1(1), FZD10(1), FZD2(2), FZD4(1), FZD6(1), FZD7(3), GNAI2(4), GNAQ(1), GNAS(4), GSK3B(1), HRAS(2), KIT(3), KITLG(1), KRAS(1), LEF1(1), MAPK1(2), MAPK3(1), MITF(2), PLCB1(18), PLCB2(2), PLCB4(21), POMC(1), PRKACA(1), PRKACB(1), PRKCA(5), PRKCG(4), RAF1(3), TCF7L1(1), TYR(3), TYRP1(4), WNT10A(3), WNT10B(1), WNT11(1), WNT2(2), WNT3(1), WNT3A(2), WNT4(2), WNT5A(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(3), WNT9B(2)	4911372	199	30	197	110	139	20	6	18	15	1	0.119	1.000	1.000
258	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR1(2), AGTR2(1), ATP8A1(7), AVPR1A(3), AVPR1B(3), BDKRB1(1), BDKRB2(3), BRS3(1), CCKAR(4), CCKBR(2), CCR1(3), CCR10(1), CCR2(6), CCR3(3), CCR4(2), CCR5(4), CCR6(1), CCR8(1), CX3CR1(3), CXCR3(1), CXCR4(1), CXCR6(1), EDNRA(3), FPR1(4), FSHR(3), GALR3(1), GALT(1), GHSR(1), GNB2L1(1), GPR77(3), GRPR(1), LHCGR(9), MC2R(4), MC3R(2), MC5R(1), NMBR(1), NPY1R(6), NPY2R(3), NPY5R(2), NTSR1(2), OPRL1(2), OXTR(2), PPYR1(5), SSTR1(2), SSTR2(2), SSTR3(2), SSTR4(1), TACR1(1), TACR2(2), TACR3(6), TRHR(3), TSHR(1)	2351498	131	30	129	109	96	9	3	13	10	0	0.472	1.000	1.000
259	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	AKT2(1), AKT3(2), ARHGAP1(1), ARHGAP4(1), ARHGEF11(7), BTK(4), CDC42(1), INPPL1(7), ITPR1(8), ITPR2(4), ITPR3(1), LIMK1(1), MYLK(11), MYLK2(2), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PAK7(15), PDK1(1), PIK3CA(3), PIK3CD(2), PIK3CG(7), PPP1R13B(2), PTEN(1), RACGAP1(1), ROCK1(2), ROCK2(4), SAG(3), WASL(4)	3194553	105	30	102	52	76	7	5	8	9	0	0.166	1.000	1.000
260	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(6), ADCY2(1), ADCY3(1), ADCY4(1), ADCY5(5), ADCY6(1), ADCY7(2), ADCY8(17), ADCY9(1), ARRB2(3), ATF2(1), ATF4(2), ATF5(2), ATP2A2(4), ATP2A3(4), CACNB3(1), CALM1(1), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CNN1(4), CNN2(1), CORIN(8), CREB3(1), CRH(1), CRHR1(2), DGKZ(1), ETS2(2), GABPB2(3), GJA1(4), GNAQ(1), GNB3(2), GNB4(3), GNB5(1), GNG2(1), GRK4(2), GRK5(2), GUCY1A3(10), IGFBP1(1), IGFBP2(1), IGFBP3(1), IL1B(1), ITPR1(8), ITPR2(4), ITPR3(1), MIB1(3), MYL2(2), MYL4(1), MYLK2(2), NFKB1(4), NOS1(20), NOS3(2), OXTR(2), PDE4B(2), PDE4D(1), PKIG(1), PLCD1(1), PLCG1(1), PLCG2(11), PRKACA(1), PRKACB(1), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(2), PRKCH(2), PRKCQ(5), PRKCZ(1), PRKD1(1), RGS11(1), RGS18(3), RGS3(3), RGS4(1), RGS6(7), RGS7(8), RGS9(3), RLN1(1), RYR1(18), RYR2(22), RYR3(22), SFN(1), SLC8A1(12), SP1(2), TNXB(31), USP5(2), YWHAQ(2)	7942468	340	30	336	216	246	33	10	27	24	0	0.388	1.000	1.000
261	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	76	ABL1(1), ACTN1(1), AKT2(1), AKT3(2), BCAR1(2), CAV1(1), CDC42(1), CRK(1), CSE1L(1), DOCK1(5), EPHB2(8), FYN(1), GRB7(1), GRLF1(5), ITGA1(11), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(13), ITGA5(8), ITGA7(3), ITGA8(7), ITGA9(3), ITGB3BP(1), MAP2K7(2), MAP3K11(3), MAPK1(2), MAPK10(5), MAPK8IP2(3), MAPK8IP3(3), MAPK9(1), MYLK(11), MYLK2(2), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PAK7(15), PIK3CA(3), PIK3CB(2), PKLR(4), PLCG1(1), PLCG2(11), PTEN(1), PTK2(2), RAF1(3), ROCK1(2), ROCK2(4), SHC1(1), SOS1(3), SOS2(5), SRC(1), TLN1(5), TLN2(6), VASP(2), WAS(2), ZYX(2)	5467463	201	30	195	90	146	18	6	16	15	0	0.0200	1.000	1.000
262	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTN2(6), ACTN3(3), DES(1), DMD(11), MYBPC1(6), MYBPC2(6), MYBPC3(3), MYH3(7), MYH6(13), MYH7(10), MYH8(18), MYL1(4), MYL2(2), MYL3(1), MYL4(1), MYOM1(12), NEB(32), TNNC2(1), TNNI2(1), TNNT1(1), TNNT3(1), TPM1(1), TTN(324), VIM(2)	6039418	467	30	458	191	349	32	17	44	22	3	0.000504	1.000	1.000
263	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(1), ACPP(2), ALPI(2), ALPL(6), ALPP(2), ALPPL2(6), CYP19A1(1), CYP1A1(2), CYP1A2(2), CYP2A13(5), CYP2A6(3), CYP2A7(2), CYP2B6(5), CYP2C18(10), CYP2C19(7), CYP2C8(11), CYP2C9(12), CYP2E1(5), CYP2F1(3), CYP2J2(2), CYP3A4(3), CYP3A5(2), CYP3A7(7), CYP4B1(7), CYP4F8(5), PON1(4)	1327558	117	29	112	65	90	7	5	4	11	0	0.0671	1.000	1.000
264	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(4), ALG6(1), CCKBR(2), CCR2(6), CCR3(3), CCR5(4), CELSR1(6), CELSR2(5), CELSR3(11), CHRM2(8), CHRM3(4), CXCR3(1), DRD4(1), EDNRA(3), EMR2(2), EMR3(2), F2R(2), FSHR(3), GPR116(9), GPR132(3), GPR133(7), GPR17(1), GPR18(1), GPR55(1), GPR56(1), GPR61(3), GPR77(3), GPR84(2), GRM1(7), GRPR(1), HRH4(1), LGR6(3), LPHN2(13), LPHN3(8), NTSR1(2), OR2M4(3), OR8G2(4), PTGFR(6), SMO(3), SSTR2(2), TSHR(1)	3037621	153	29	151	107	106	11	4	20	11	1	0.531	1.000	1.000
265	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(4), AKR1D1(6), ARSD(1), ARSE(3), CARM1(2), CYP11B1(5), CYP11B2(3), CYP19A1(1), HSD11B1(1), HSD11B2(1), HSD17B2(2), HSD17B7(1), HSD3B1(4), METTL2B(2), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(3), SRD5A1(1), SRD5A2(2), STS(1), SULT1E1(6), SULT2A1(4), UGT1A1(1), UGT1A10(7), UGT1A3(3), UGT1A4(3), UGT1A5(4), UGT1A6(2), UGT1A7(5), UGT1A8(2), UGT1A9(5), UGT2A1(9), UGT2A3(5), UGT2B10(9), UGT2B11(7), UGT2B15(3), UGT2B28(8), UGT2B4(9), UGT2B7(5)	2266792	146	29	143	60	101	18	2	11	13	1	0.00977	1.000	1.000
266	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH5(1), ADH6(2), ADH7(1), ADHFE1(2), AGK(1), AGPAT2(1), AGPAT3(2), AGPAT4(3), AKR1A1(1), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), CEL(2), DAK(1), DGKB(6), DGKD(2), DGKE(1), DGKG(2), DGKH(6), DGKI(6), DGKZ(1), GK(3), GK2(14), GLB1(2), LCT(13), LIPA(1), LIPC(4), LIPF(3), LIPG(2), LPL(1), MGLL(1), PNLIP(2), PNLIPRP1(1), PNLIPRP2(1), PPAP2B(4), PPAP2C(2)	2682525	133	29	129	62	86	15	4	15	13	0	0.106	1.000	1.000
267	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(3), ALOX12(2), ALOX12B(5), ALOX15(4), ALOX15B(2), ALOX5(4), CYP2B6(5), CYP2C18(10), CYP2C19(7), CYP2C8(11), CYP2C9(12), CYP2E1(5), CYP2J2(2), CYP4A11(5), CYP4A22(5), CYP4F2(2), CYP4F3(4), GGT1(1), GPX3(1), GPX5(1), GPX6(6), LTA4H(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), PTGDS(1), PTGIS(4), PTGS1(5), PTGS2(3), TBXAS1(6)	1766914	135	29	133	65	114	7	1	5	8	0	0.00594	1.000	1.000
268	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	108	ABL1(1), ANAPC1(2), ANAPC2(3), ANAPC4(2), ANAPC5(2), ATM(2), ATR(8), BUB1(1), BUB1B(4), CCNA1(2), CCNB3(9), CCND1(1), CCND2(1), CCNE1(1), CCNE2(3), CDC20(1), CDC23(1), CDC25A(3), CDC25B(1), CDC25C(1), CDC27(5), CDK4(2), CDK6(1), CDKN1A(1), CDKN1B(1), CDKN2C(1), CREBBP(4), CUL1(2), E2F1(2), E2F2(1), EP300(7), ESPL1(2), FZR1(2), GSK3B(1), MAD1L1(2), MCM2(4), MCM3(6), MCM5(1), MCM6(2), ORC1L(4), ORC5L(1), PRKDC(6), PTTG2(2), RB1(2), RBL1(2), RBL2(1), SFN(1), SMAD2(1), SMAD3(1), SMC1B(1), TFDP1(1), WEE1(2), YWHAE(1), YWHAG(1), YWHAQ(2)	6154309	125	29	125	50	77	8	12	15	12	1	0.0983	1.000	1.000
269	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP4(1), BMP5(9), BMP6(1), BMP8A(1), BTRC(3), CSNK1A1L(1), CSNK1E(1), CSNK1G1(2), CSNK1G2(1), CSNK1G3(1), DHH(1), FBXW11(2), GLI1(1), GLI2(9), GLI3(3), GSK3B(1), HHIP(5), IHH(2), LRP2(30), PRKACA(1), PRKACB(1), PTCH1(2), PTCH2(6), SHH(1), SMO(3), STK36(3), SUFU(1), WNT10A(3), WNT10B(1), WNT11(1), WNT2(2), WNT3(1), WNT3A(2), WNT4(2), WNT5A(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(3), WNT9B(2)	2756120	119	29	119	60	76	16	7	10	10	0	0.212	1.000	1.000
270	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1B(1), ACVR2A(1), ACVR2B(1), ACVRL1(3), BMP2(1), BMP4(1), BMP5(9), BMP6(1), BMP8A(1), BMPR1B(2), BMPR2(1), CHRD(7), COMP(1), CREBBP(4), CUL1(2), DCN(6), E2F4(1), EP300(7), FST(3), GDF5(3), INHBA(2), INHBB(2), INHBC(2), LEFTY1(1), LEFTY2(1), LTBP1(10), MAPK1(2), MAPK3(1), MYC(2), NODAL(1), NOG(1), PPP2CB(1), PPP2R1B(2), PPP2R2A(2), PPP2R2B(1), PPP2R2C(2), RBL1(2), RBL2(1), ROCK1(2), ROCK2(4), RPS6KB1(1), RPS6KB2(1), SMAD1(2), SMAD2(1), SMAD3(1), SMAD6(3), SMAD7(1), SMAD9(4), SMURF2(5), SP1(2), TFDP1(1), TGFBR2(2), THBS1(10), THBS2(2), THBS3(3), THBS4(4), ZFYVE9(3)	4527278	144	29	143	61	100	15	8	10	11	0	0.0931	1.000	1.000
271	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACTB(2), ACTG1(1), ACTN1(1), ACTN2(6), ACTN3(3), ACVR1B(1), BAIAP2(2), CDC42(1), CREBBP(4), CSNK2A1(1), CTNNA1(2), CTNNA2(8), CTNNA3(13), CTNNB1(3), CTNND1(4), EGFR(6), EP300(7), ERBB2(4), FARP2(1), FGFR1(4), FYN(1), IGF1R(1), INSR(3), IQGAP1(4), LEF1(1), LMO7(10), MAP3K7(1), MAPK1(2), MAPK3(1), MET(7), MLLT4(2), NLK(2), PARD3(6), PTPN1(1), PTPRB(16), PTPRF(11), PTPRJ(4), PTPRM(1), PVRL1(3), PVRL2(2), PVRL3(4), PVRL4(3), RAC2(1), SMAD2(1), SMAD3(1), SNAI1(1), SNAI2(1), SORBS1(2), SRC(1), SSX2IP(2), TCF7L1(1), TGFBR2(2), TJP1(2), VCL(2), WAS(2), WASF3(7), WASL(4)	5460053	190	29	189	105	125	15	6	20	23	1	0.710	1.000	1.000
272	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	CANX(1), CD4(1), CD74(3), CD8B(1), CIITA(4), CTSS(3), HLA-A(2), HLA-B(2), HLA-DMA(1), HLA-DMB(3), HLA-DOA(1), HLA-DQA1(3), HLA-DQA2(4), HLA-DQB1(3), HLA-DRA(3), HLA-DRB1(2), HLA-DRB5(1), HLA-F(1), HLA-G(1), HSPA5(1), IFI30(2), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(1), IFNA21(2), IFNA4(1), IFNA5(1), IFNA8(1), KIR2DL1(6), KIR2DL3(2), KIR2DL4(1), KIR2DS4(3), KIR3DL1(3), KIR3DL2(1), KIR3DL3(3), KLRC3(3), KLRC4(2), KLRD1(1), LGMN(2), LTA(1), NFYB(1), PSME2(1), RFX5(3), TAP2(4), TAPBP(1)	2103804	90	29	88	44	66	13	3	4	4	0	0.101	1.000	1.000
273	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	123	CD244(2), CD48(1), CHP(1), FAS(1), FASLG(2), FCGR3A(2), FYN(1), HLA-A(2), HLA-B(2), HLA-G(1), HRAS(2), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(1), IFNA21(2), IFNA4(1), IFNA5(1), IFNA8(1), IFNAR1(1), IFNB1(1), IFNGR1(2), IFNGR2(1), ITGAL(8), ITGB2(6), KIR2DL1(6), KIR2DL3(2), KIR2DL4(1), KIR3DL1(3), KIR3DL2(1), KLRC3(3), KLRD1(1), KLRK1(2), KRAS(1), LCK(3), LCP2(3), MAPK1(2), MAPK3(1), MICA(2), NCR1(1), NCR2(3), NCR3(1), NFAT5(2), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PLCG1(1), PLCG2(11), PPP3R2(1), PRF1(2), PRKCA(5), PRKCG(4), PTK2B(2), PTPN11(5), RAC2(1), RAF1(3), SH2D1A(1), SH2D1B(1), SH3BP2(1), SHC1(1), SHC2(3), SHC3(1), SHC4(2), SOS1(3), SOS2(5), SYK(4), TNFRSF10A(2), TNFRSF10C(1), TNFRSF10D(4), TNFSF10(1), ULBP3(2), VAV1(2), VAV3(4), ZAP70(2)	5045100	189	29	188	101	128	20	9	15	17	0	0.340	1.000	1.000
274	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	72	C7orf16(1), CACNA1A(7), CRH(1), CRHR1(2), GNA11(1), GNA12(1), GNAI2(4), GNAQ(1), GNAS(4), GNAZ(3), GRIA1(13), GRIA2(5), GRIA3(10), GRID2(16), GRM1(7), GRM5(4), GUCY1A2(6), GUCY1A3(10), GUCY1B3(1), GUCY2C(10), GUCY2D(4), GUCY2F(7), HRAS(2), IGF1R(1), ITPR1(8), ITPR2(4), ITPR3(1), KRAS(1), LYN(2), MAPK1(2), MAPK3(1), NOS1(20), NOS3(2), NPR1(1), NPR2(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), PLCB1(18), PLCB2(2), PLCB4(21), PPP2CB(1), PPP2R1B(2), PPP2R2A(2), PPP2R2B(1), PPP2R2C(2), PRKCA(5), PRKCG(4), PRKG1(7), PRKG2(4), RAF1(3), RYR1(18)	4907591	272	29	268	151	194	24	9	26	18	1	0.0952	1.000	1.000
275	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	94	ADCY1(6), ADCY2(1), ADCY3(1), ADCY4(1), ADCY5(5), ADCY6(1), ADCY7(2), ADCY8(17), ADCY9(1), ATF4(2), CACNA1C(8), CACNA1D(8), CACNA1F(7), CACNA1S(13), CALM1(1), CALML3(3), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CDC42(1), EGFR(6), ELK1(1), GNA11(1), GNAQ(1), GNAS(4), HRAS(2), ITPR1(8), ITPR2(4), ITPR3(1), KRAS(1), MAP2K3(2), MAP2K7(2), MAP3K2(1), MAP3K3(1), MAP3K4(4), MAPK1(2), MAPK10(5), MAPK13(1), MAPK14(3), MAPK3(1), MAPK7(2), MAPK9(1), MMP14(2), MMP2(3), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), PLCB1(18), PLCB2(2), PLCB4(21), PLD1(3), PLD2(2), PRKACA(1), PRKACB(1), PRKCA(5), PRKCD(2), PTK2B(2), RAF1(3), SOS1(3), SOS2(5), SRC(1)	5739048	229	29	227	155	161	23	11	18	15	1	0.689	1.000	1.000
276	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	89	AKT3(2), BCAR1(2), CAPN1(1), CAPN10(2), CAPN11(2), CAPN2(1), CAPN3(2), CAPN5(2), CAPN6(3), CAPN9(3), CAV1(1), CDC42(1), CRK(1), DOCK1(5), FYN(1), GIT2(1), ITGA10(2), ITGA11(3), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(13), ITGA5(8), ITGA7(3), ITGA8(7), ITGA9(3), ITGAD(6), ITGAE(6), ITGAL(8), ITGAM(9), ITGAV(3), ITGAX(5), ITGB1(2), ITGB2(6), ITGB3(2), ITGB4(4), ITGB5(2), ITGB6(2), ITGB7(2), ITGB8(8), MAP2K3(2), MAPK10(5), MAPK4(5), MAPK6(1), MAPK7(2), MYLK2(2), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PDPK1(2), PTK2(2), RAC2(1), RAP1B(1), RAPGEF1(3), ROCK1(2), ROCK2(4), SDCCAG8(1), SHC1(1), SHC3(1), SORBS1(2), SOS1(3), SRC(1), TLN1(5), TNS1(2), VASP(2), VAV3(4), VCL(2), ZYX(2)	6057868	205	29	204	97	146	18	6	21	14	0	0.0630	1.000	1.000
277	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(2), BMPR1B(2), CCND2(1), CDK4(2), CDKN1B(1), DMC1(1), ESR2(2), FSHR(3), GJA4(2), INHA(2), LHCGR(9), MLH1(1), MSH5(4), NCOR1(4), NR5A1(2), NRIP1(2), PGR(6), PRLR(9), PTGER2(1), ZP2(2)	1587524	58	29	56	42	43	4	2	6	3	0	0.955	1.000	1.000
278	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1B(1), ACVRL1(3), BMPR2(1), BUB1(1), CDKL1(3), CDKL2(1), CDS1(2), CDS2(1), CLK1(1), CLK2(1), COL4A3BP(1), CSNK2A1(1), DGKB(6), DGKD(2), DGKE(1), DGKG(2), DGKH(6), DGKZ(1), INPP1(1), INPP4B(1), INPP5A(2), INPPL1(7), ITPKB(2), MAP3K10(2), NEK1(1), OCRL(2), PAK4(2), PIK3C2A(1), PIK3C2B(2), PIK3C2G(13), PIK3CA(3), PIK3CB(2), PIK3CG(7), PIM2(2), PLCB1(18), PLCB2(2), PLCB4(21), PLCD1(1), PLCG1(1), PLCG2(11), PRKACA(1), PRKACB(1), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(2), PRKCG(4), PRKCH(2), PRKCQ(5), PRKCZ(1), PRKD1(1), PRKG1(7), RAF1(3), RPS6KA1(3), RPS6KB1(1), STK11(1)	5132850	181	29	178	108	132	15	6	12	15	1	0.696	1.000	1.000
279	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(6), ADCY2(1), ADCY3(1), ADCY4(1), ADCY5(5), ADCY6(1), ADCY7(2), ADCY8(17), ADK(1), AK2(2), AK5(1), ALLC(2), AMPD1(7), AMPD3(2), ATIC(2), ATP5B(1), ATP5C1(1), ATP5F1(2), ATP5G2(1), ATP5H(1), CANT1(4), DGUOK(2), ENPP1(4), ENPP3(7), ENTPD1(2), ENTPD2(1), GART(2), GDA(4), GMPS(1), GUCY1A2(6), GUCY1A3(10), GUCY1B3(1), GUCY2C(10), GUCY2D(4), GUCY2F(7), NPR1(1), NPR2(2), NT5E(1), NT5M(1), PAICS(1), PAPSS2(2), PDE1A(10), PDE4A(2), PDE4B(2), PDE4C(2), PDE4D(1), PDE5A(3), PDE6B(2), PDE6C(10), PDE7B(4), PDE9A(3), PFAS(2), PKLR(4), PKM2(1), POLD1(1), POLD2(1), POLE(6), POLL(4), POLQ(9), POLR1B(4), POLR2A(1), POLR2B(6), POLR2E(1), POLRMT(1), PRPS1L1(4), PRPS2(1), PRUNE(1), RRM1(1)	5833899	218	29	213	109	147	16	8	30	17	0	0.0749	1.000	1.000
280	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT2(1), AKT3(2), CDC42(1), CDKN1B(1), CREB3(1), CREB5(2), ERBB4(13), F2RL2(3), GAB1(1), GSK3B(1), IGFBP1(1), INPPL1(7), IRS2(1), IRS4(3), MET(7), MYC(2), NOLC1(1), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PAK7(15), PARD3(6), PARD6A(1), PDK1(1), PIK3CA(3), PIK3CD(2), PPP1R13B(2), PREX1(2), PTEN(1), PTK2(2), PTPN1(1), RPS6KA1(3), RPS6KB1(1), SFN(1), SHC1(1), SLC2A4(4), SOS1(3), SOS2(5), TSC1(1), TSC2(3), YWHAE(1), YWHAG(1), YWHAQ(2)	3500944	119	29	117	55	86	11	4	7	11	0	0.107	1.000	1.000
281	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ABP1(5), ACMSD(5), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), AOC3(4), AOX1(5), ASMT(3), CAT(1), CYP19A1(1), CYP1A1(2), CYP1A2(2), CYP2A13(5), CYP2A6(3), CYP2A7(2), CYP2B6(5), CYP2C18(10), CYP2C19(7), CYP2C8(11), CYP2C9(12), CYP2E1(5), CYP2F1(3), CYP2J2(2), CYP3A4(3), CYP3A5(2), CYP3A7(7), CYP4B1(7), CYP4F8(5), DDC(5), EHHADH(1), GCDH(1), HAAO(2), HADHA(1), KMO(5), KYNU(2), MAOB(6), SDS(1), TDO2(1), TPH1(1), WARS(3), WARS2(1)	2505016	160	29	157	87	110	15	9	13	13	0	0.147	1.000	1.000
282	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(1), BAX(2), BCL2L11(3), BIRC3(1), BIRC5(1), CASP1(1), CASP10(1), CASP2(1), CASP7(2), CASP8(1), CASP9(2), CHUK(1), DFFB(1), FAS(1), FASLG(2), HELLS(1), IRF2(1), IRF3(1), IRF5(2), IRF6(3), IRF7(2), LTA(1), MAPK10(5), MYC(2), NFKB1(4), NFKBIA(1), NFKBIB(1), PLEKHG5(4), PRF1(2), RELA(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(3), TNFSF10(1), TP73(2), TRAF1(2), TRAF3(3)	2571112	66	28	66	35	51	7	2	1	5	0	0.450	1.000	1.000
283	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(2), CABIN1(4), CALM1(1), CAMK2B(1), CAMK4(3), CD69(1), CDKN1A(1), CNR1(1), CREBBP(4), CSNK2A1(1), CTLA4(1), EGR3(1), EP300(7), FCER1A(2), FCGR3A(2), GATA4(1), GRLF1(5), GSK3B(1), HRAS(2), ICOS(1), IFNA1(1), IFNB1(1), IL10(2), IL1B(1), IL2(1), IL4(1), ITK(8), MAP2K7(2), MAPK14(3), MAPK9(1), MEF2A(2), MEF2D(1), MYF5(3), NCK2(1), NFAT5(2), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), NFKBIB(1), NPPB(1), NUP214(4), PIN1(1), PPIA(1), PTPRC(4), RELA(1), SFN(1), SLA(1), SP1(2), TRPV6(10), VAV1(2), VAV3(4), XPO5(3)	4156982	122	28	121	70	84	9	5	10	14	0	0.605	1.000	1.000
284	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(1), ATM(2), BUB1(1), BUB1B(4), CCNA1(2), CCNB3(9), CCND2(1), CCNE1(1), CCNE2(3), CDAN1(1), CDC20(1), CDC25A(3), CDC25B(1), CDC25C(1), CDK4(2), CDKN1A(1), DTX4(1), E2F1(2), E2F2(1), E2F4(1), EP300(7), ESPL1(2), GSK3B(1), HDAC3(3), HDAC4(2), HDAC5(4), HDAC6(1), MAD1L1(2), MCM2(4), MCM3(6), MCM5(1), MCM6(2), MPL(3), ORC1L(4), ORC5L(1), PRKDC(6), PTPRA(2), PTTG2(2), RB1(2), RBL1(2), TBC1D8(3), TFDP1(1), WEE1(2)	4935492	102	28	102	48	64	8	8	15	6	1	0.286	1.000	1.000
285	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	11	C1R(2), C1S(3), C2(2), C3(14), C5(2), C6(18), C8B(11), C9(5), MASP1(2)	820021	59	28	57	33	46	3	0	6	4	0	0.511	1.000	1.000
286	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH6(2), ADH7(1), ADHFE1(2), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH3B1(1), ALDH3B2(2), ALDOA(1), ALDOB(4), BPGM(1), DLAT(1), DLD(1), ENO1(2), FBP1(1), G6PC(4), GAPDH(1), GCK(2), HK2(5), HK3(3), LDHC(3), PDHA2(6), PGK1(1), PGM1(1), PGM3(1), PKLR(4), PKM2(1)	2228301	92	28	90	32	63	10	3	10	6	0	0.00224	1.000	1.000
287	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH6(2), ADH7(1), ADHFE1(2), AGPAT2(1), AGPAT3(2), AGPAT4(3), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), CEL(2), DGKB(6), DGKD(2), DGKE(1), DGKG(2), DGKH(6), DGKZ(1), GK(3), GLB1(2), LCT(13), LIPC(4), LIPF(3), LIPG(2), LPL(1), PNLIP(2), PNLIPRP1(1), PNLIPRP2(1), PPAP2B(4), PPAP2C(2)	2201410	110	28	106	57	74	13	3	11	9	0	0.278	1.000	1.000
288	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH6(2), ADH7(1), ADHFE1(2), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH3B1(1), ALDH3B2(2), ALDOA(1), ALDOB(4), BPGM(1), DLAT(1), DLD(1), ENO1(2), FBP1(1), G6PC(4), GAPDH(1), GCK(2), HK2(5), HK3(3), LDHC(3), PDHA2(6), PGK1(1), PGM1(1), PGM3(1), PKLR(4), PKM2(1)	2228301	92	28	90	32	63	10	3	10	6	0	0.00224	1.000	1.000
289	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(4), DLAT(1), DLD(1), ENO1(2), FBP1(1), G6PC(4), GAPDH(1), GAPDHS(1), GCK(2), GOT2(1), HK2(5), HK3(3), LDHAL6B(1), LDHC(3), MDH2(2), PC(1), PCK1(8), PDHA2(6), PDHX(1), PFKL(2), PGAM2(1), PGK1(1), PGK2(4), PKLR(4), PKM2(1)	1941219	62	28	61	26	49	5	4	3	1	0	0.0161	1.000	1.000
290	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(2), ACAA2(1), ACADL(3), ACADM(1), ACADS(2), ACADSB(1), ACADVL(1), ACOX1(1), ACOX3(2), ACSL1(1), ACSL3(2), ACSL4(2), ACSL5(9), ACSL6(4), ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH5(1), ADH6(2), ADH7(1), ADHFE1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), CPT1A(1), CPT1B(3), CPT1C(1), CYP4A11(5), CYP4A22(5), DCI(1), EHHADH(1), GCDH(1), HADHA(1), HADHB(2), HSD17B4(1)	2244859	98	28	97	46	67	8	4	9	10	0	0.203	1.000	1.000
291	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA2(1), INPP1(1), INPP4B(1), INPP5A(2), INPP5B(2), INPPL1(7), ITPK1(2), ITPKB(2), MIOX(1), OCRL(2), PI4KA(4), PI4KB(2), PIK3C3(1), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIP4K2A(1), PIP4K2B(1), PIP5K1A(2), PIP5K1B(4), PIP5K1C(1), PLCB1(18), PLCB2(2), PLCB4(21), PLCD1(1), PLCE1(15), PLCG1(1), PLCG2(11), PLCZ1(7), PTEN(1), SYNJ1(9), SYNJ2(6)	3374324	143	28	141	64	111	9	5	6	11	1	0.0185	1.000	1.000
292	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	83	ABL1(1), ABL2(5), AKT2(1), AKT3(2), AREG(1), BTC(1), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CBL(2), CBLB(5), CBLC(1), CDKN1A(1), CDKN1B(1), CRK(1), EGF(4), EGFR(6), ELK1(1), ERBB2(4), ERBB3(1), ERBB4(13), EREG(3), GAB1(1), GSK3B(1), HRAS(2), KRAS(1), MAP2K7(2), MAPK1(2), MAPK10(5), MAPK3(1), MAPK9(1), MYC(2), NCK2(1), NRG1(2), NRG2(1), NRG3(6), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PAK7(15), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PLCG1(1), PLCG2(11), PRKCA(5), PRKCG(4), PTK2(2), RAF1(3), RPS6KB1(1), RPS6KB2(1), SHC1(1), SHC2(3), SHC3(1), SHC4(2), SOS1(3), SOS2(5), SRC(1), STAT5A(1), STAT5B(1)	4599130	175	28	171	87	128	17	7	12	11	0	0.175	1.000	1.000
293	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(6), CD19(1), CD1A(4), CD1B(2), CD1C(7), CD1D(1), CD1E(7), CD2(11), CD22(7), CD33(6), CD34(1), CD36(2), CD37(1), CD3D(2), CD4(1), CD44(1), CD5(2), CD55(1), CD8B(1), CR1(13), CR2(10), CSF1(3), CSF1R(3), CSF2RA(6), CSF3(2), CSF3R(1), DNTT(4), EPO(2), EPOR(1), FCER2(1), FCGR1A(1), FLT3(7), GP5(1), GP9(1), GYPA(3), HLA-DRA(3), HLA-DRB1(2), HLA-DRB5(1), IL11RA(1), IL1A(3), IL1B(1), IL1R1(3), IL1R2(1), IL4(1), IL4R(3), IL5RA(7), IL7(2), IL7R(6), IL9R(1), ITGA1(11), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(13), ITGA5(8), ITGAM(9), ITGB3(2), KIT(3), KITLG(1), MME(6), MS4A1(3), TFRC(1), THPO(2), TPO(11)	3707943	232	28	228	96	165	13	8	17	29	0	0.00650	1.000	1.000
294	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT2(1), AKT3(2), BCL10(1), BLNK(4), BTK(4), CARD11(9), CD19(1), CD22(7), CD72(1), CHP(1), CHUK(1), CR2(10), FCGR2B(1), GSK3B(1), HRAS(2), INPP5D(13), KRAS(1), LILRB3(2), LYN(2), MALT1(3), NFAT5(2), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), NFKB1(4), NFKBIA(1), NFKBIB(1), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PLCG2(11), PPP3R2(1), RAC2(1), RASGRP3(3), SYK(4), VAV1(2), VAV3(4)	3364973	132	28	132	59	87	11	8	9	17	0	0.0659	1.000	1.000
295	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), ARRB2(3), CALM1(1), CALML3(3), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CLCA2(3), CLCA4(8), CNGA3(9), CNGA4(5), CNGB1(6), GUCA1A(1), GUCA1C(2), PDC(1), PDE1C(13), PRKACA(1), PRKACB(1), PRKG1(7), PRKG2(4)	1379332	75	28	74	41	50	6	2	11	6	0	0.359	1.000	1.000
296	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(3), ADCY4(1), ADCY6(1), ADCY8(17), CACNA1A(7), CACNA1B(6), GNAS(4), GNAT3(1), GNB3(2), GRM4(8), ITPR3(1), KCNB1(10), PDE1A(10), PLCB2(2), PRKACA(1), PRKACB(1), SCNN1A(3), SCNN1B(3), SCNN1G(9), TAS1R1(1), TAS1R2(7), TAS2R1(2), TAS2R10(2), TAS2R16(2), TAS2R38(3), TAS2R39(1), TAS2R4(1), TAS2R40(1), TAS2R41(6), TAS2R5(1), TAS2R60(6), TAS2R8(1), TAS2R9(2), TRPM5(2)	2587015	128	28	123	118	89	12	4	14	9	0	0.935	1.000	1.000
297	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(5), ACSL1(1), ACSL3(2), ACSL4(2), ACSL5(9), ACSL6(4), ADIPOQ(1), ADIPOR1(2), ADIPOR2(1), AKT2(1), AKT3(2), CAMKK2(3), CD36(2), CHUK(1), CPT1A(1), CPT1B(3), CPT1C(1), G6PC(4), IRS2(1), IRS4(3), JAK1(1), JAK2(1), LEP(1), LEPR(6), MAPK10(5), MAPK9(1), NFKB1(4), NFKBIA(1), NFKBIB(1), NPY(1), PCK1(8), POMC(1), PPARA(1), PPARGC1A(3), PRKAA1(1), PRKAA2(4), PRKAB1(1), PRKAG1(1), PRKAG2(4), PRKAG3(5), PRKCQ(5), PTPN11(5), RELA(1), RXRA(2), RXRB(2), RXRG(2), SLC2A1(1), SLC2A4(4), STAT3(1), STK11(1), TNFRSF1A(1), TNFRSF1B(2), TYK2(3)	3790974	130	28	128	70	88	11	5	10	16	0	0.367	1.000	1.000
298	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(1), ACTB(2), ACTG1(1), ARHGEF2(5), ARPC5(1), CDC42(1), CLDN1(1), CTNNB1(3), FYN(1), HCLS1(3), ITGB1(2), KRT18(1), NCK2(1), OCLN(1), PRKCA(5), ROCK1(2), ROCK2(4), TLR4(8), TLR5(5), TUBA1A(1), TUBA3C(7), TUBA3D(3), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB1(2), TUBB2A(1), TUBB4(2), TUBB6(4), TUBB8(5), WAS(2), WASL(4), YWHAQ(2)	2392462	86	28	86	32	57	10	2	9	8	0	0.0120	1.000	1.000
299	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(1), ACTB(2), ACTG1(1), ARHGEF2(5), ARPC5(1), CDC42(1), CLDN1(1), CTNNB1(3), FYN(1), HCLS1(3), ITGB1(2), KRT18(1), NCK2(1), OCLN(1), PRKCA(5), ROCK1(2), ROCK2(4), TLR4(8), TLR5(5), TUBA1A(1), TUBA3C(7), TUBA3D(3), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB1(2), TUBB2A(1), TUBB4(2), TUBB6(4), TUBB8(5), WAS(2), WASL(4), YWHAQ(2)	2392462	86	28	86	32	57	10	2	9	8	0	0.0120	1.000	1.000
300	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(12), COL4A2(8), COL4A3(11), COL4A4(23), COL4A5(13), COL4A6(14), F10(2), F11(2), F2(3), F2R(2), F5(9), F8(12), F9(3), FGA(11), FGG(2), KLKB1(7), PROC(1), PROS1(4), SERPINC1(1)	2021574	140	28	136	36	109	9	6	14	2	0	0.0424	1.000	1.000
301	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	82	ATF2(1), CHUK(1), DAXX(5), ELK1(1), HRAS(2), MAP2K3(2), MAP2K5(1), MAP2K7(2), MAP3K10(2), MAP3K11(3), MAP3K12(1), MAP3K13(2), MAP3K14(2), MAP3K2(1), MAP3K3(1), MAP3K4(4), MAP3K5(7), MAP3K6(1), MAP3K7(1), MAP3K9(8), MAP4K1(4), MAP4K3(1), MAP4K4(4), MAPK1(2), MAPK10(5), MAPK13(1), MAPK14(3), MAPK3(1), MAPK4(5), MAPK6(1), MAPK7(2), MAPK9(1), MAPKAPK2(2), MAPKAPK3(1), MEF2A(2), MEF2C(1), MEF2D(1), MKNK1(1), MYC(2), NFKB1(4), NFKBIA(1), PAK2(2), RAF1(3), RELA(1), RPS6KA1(3), RPS6KA5(1), RPS6KB1(1), RPS6KB2(1), SHC1(1), SP1(2), STAT1(3)	4234626	111	28	110	48	71	16	4	14	6	0	0.138	1.000	1.000
302	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(2), ADRA1B(2), ADRA1D(1), ADRA2A(1), ADRB1(3), CHRM1(2), CHRM2(8), CHRM3(4), CHRM4(2), CHRM5(2), DRD1(1), DRD2(2), DRD3(3), DRD4(1), DRD5(6), HRH1(4), HTR1A(2), HTR1D(3), HTR1E(1), HTR1F(5), HTR2A(2), HTR2B(2), HTR2C(3), HTR4(5), HTR5A(5), HTR6(1), HTR7(3)	1148026	76	28	76	47	48	9	3	9	7	0	0.0691	1.000	1.000
303	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	BDKRB2(3), CALM1(1), CAV1(1), CHRM1(2), CHRNA1(3), FLT1(6), FLT4(8), KDR(8), NOS3(2), PDE2A(1), PDE3A(7), PDE3B(1), PRKACB(1), PRKAR2B(3), PRKG1(7), PRKG2(4), RYR2(22), SYT1(4)	1866785	84	28	84	72	54	8	1	8	13	0	0.986	1.000	1.000
304	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT2(1), AKT3(2), BCR(5), BLNK(4), BTK(4), CD19(1), CD22(7), CR2(10), DAG1(2), FLOT1(1), GSK3B(1), INPP5D(13), ITPR1(8), ITPR2(4), ITPR3(1), LYN(2), MAP4K1(4), MAPK1(2), MAPK3(1), NFATC1(5), NFATC2(1), NR0B2(1), PDK1(1), PIK3CA(3), PIK3CD(2), PLCG2(11), PPP1R13B(2), PTPRC(4), RAF1(3), SHC1(1), SOS1(3), SOS2(5), SYK(4), VAV1(2)	3377098	121	28	121	59	80	12	9	9	11	0	0.146	1.000	1.000
305	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT2(1), AKT3(2), BRD4(5), CAP1(1), CBL(2), CDC42(1), F2RL2(3), FLOT1(1), GSK3B(1), IGFBP1(1), INPPL1(7), IRS2(1), IRS4(3), LNPEP(1), MAPK1(2), MAPK3(1), PARD3(6), PARD6A(1), PDK1(1), PIK3CA(3), PIK3CD(2), PPYR1(5), PTEN(1), PTPN1(1), RAF1(3), RPS6KA1(3), RPS6KB1(1), SERPINB6(2), SFN(1), SHC1(1), SLC2A4(4), SORBS1(2), SOS1(3), SOS2(5), YWHAE(1), YWHAG(1), YWHAQ(2)	2695595	82	28	82	40	54	10	4	6	8	0	0.366	1.000	1.000
306	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), ACTG2(1), CDC42(1), FLNA(5), FLNC(20), FSCN1(1), FSCN2(2), FSCN3(3), LIMK1(1), MYH2(22), MYLK(11), MYLK2(2), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PAK7(15), ROCK1(2), ROCK2(4), VASP(2), WASL(4)	2182820	106	28	102	59	77	12	2	5	10	0	0.181	1.000	1.000
307	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	ALG2(2), BAX(2), BTK(4), CAD(5), CASP10(1), CASP8(1), CASP8AP2(1), DAXX(5), EGFR(6), EPHB2(8), HSPB1(2), IL1A(3), MAP2K7(2), MAP3K5(7), MAPK1(2), MAPK10(5), MAPK8IP2(3), MAPK8IP3(3), MAPK9(1), MET(7), NFAT5(2), NFKB1(4), NFKBIA(1), NFKBIB(1), NFKBIL2(1), NR0B2(1), PTPN13(3), ROCK1(2), TPX2(1), TUFM(2)	3271943	88	28	86	53	54	9	6	8	11	0	0.712	1.000	1.000
308	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT2(1), AKT3(2), DAG1(2), DRD2(2), EGFR(6), EPHB2(8), ITPKB(2), ITPR1(8), ITPR2(4), ITPR3(1), KCNJ3(8), KCNJ5(3), MAPK1(2), PI3(1), PIK3CB(2), PLCB1(18), PLCB2(2), PLCB4(21), RAF1(3), SHC1(1), SOS1(3), SOS2(5), SRC(1), STAT3(1)	2602682	107	28	105	66	78	12	7	3	6	1	0.466	1.000	1.000
309	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(5), AXIN1(4), CCND1(1), CCND2(1), CSNK1E(1), CTNNB1(3), DVL3(1), FBXW2(1), FZD1(1), FZD10(1), FZD2(2), FZD6(1), FZD7(3), GSK3B(1), LDLR(2), MAPK10(5), MAPK9(1), MYC(2), PAFAH1B1(1), PPP2R5C(1), PRKCA(5), PRKCD(2), PRKCE(2), PRKCG(4), PRKCH(2), PRKCI(2), PRKCQ(5), PRKCZ(1), PRKD1(1), SFRP4(1), WNT10A(3), WNT10B(1), WNT11(1), WNT2(2), WNT3(1), WNT4(2), WNT5A(2), WNT7A(3), WNT7B(1)	2709509	79	28	79	44	50	9	4	7	9	0	0.445	1.000	1.000
310	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(6), CARM1(2), CTCFL(5), DOT1L(4), EED(1), EHMT1(2), EZH2(2), FBXO11(2), HCFC1(4), JMJD4(2), KDM6A(1), MEN1(1), MLL(10), MLL2(12), MLL3(18), MLL4(3), NSD1(5), OGT(2), PPP1CB(3), PPP1CC(1), PRDM2(3), PRDM7(2), PRDM9(17), PRMT1(1), PRMT5(2), PRMT7(2), PRMT8(3), RBBP5(1), SATB1(4), SETD1A(8), SETD2(3), SETD7(2), SETDB1(4), SETDB2(2), SUV39H1(1), SUV420H1(1), WHSC1L1(2)	5385168	144	27	143	55	98	15	7	18	6	0	0.120	1.000	1.000
311	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(4), AKR1D1(6), ARSD(1), ARSE(3), CYP11B1(5), CYP11B2(3), HSD11B1(1), HSD11B2(1), HSD17B2(2), HSD3B1(4), SRD5A1(1), SRD5A2(2), STS(1), SULT1E1(6), SULT2A1(4), UGT1A1(1), UGT1A10(7), UGT1A3(3), UGT1A4(3), UGT1A5(4), UGT1A6(2), UGT1A7(5), UGT1A8(2), UGT1A9(5), UGT2B15(3), UGT2B4(9)	1236990	88	27	85	38	58	11	2	7	9	1	0.0426	1.000	1.000
312	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(5), AGMAT(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH4A1(1), AOC3(4), ARG2(1), ASL(1), CKMT2(1), CPS1(8), DAO(4), GAMT(2), GATM(1), GOT2(1), MAOB(6), NOS1(20), NOS3(2), OAT(2), P4HA1(4), P4HA2(1), P4HA3(4), PYCR1(1), RARS(4), SMS(1)	2010765	87	27	87	46	56	12	3	7	9	0	0.250	1.000	1.000
313	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(2), F11(2), F13B(6), F2(3), F5(9), F7(2), F8(12), F9(3), FGA(11), FGG(2), LPA(18), PLAT(1), PLG(11), SERPINB2(3), SERPINE1(2), SERPINF2(1), VWF(16)	1598811	104	27	103	42	77	9	5	5	8	0	0.117	1.000	1.000
314	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(2), CCNA1(2), CCND1(1), CCND2(1), CCNE1(1), CCNE2(3), CDC25A(3), CDK4(2), CDKN1A(1), CDKN1B(1), CDKN2C(1), CREB3(1), CREB3L1(3), CREB3L3(6), CREB3L4(2), E2F1(2), E2F2(1), E2F4(1), MCM2(4), MCM3(6), MCM5(1), MCM6(2), MYC(2), MYT1(4), ORC1L(4), ORC5L(1), POLA2(2), POLE(6), POLE2(1), RB1(2), RBL1(2), TFDP1(1), TNXB(31), WEE1(2)	3538526	105	27	104	38	68	9	4	14	9	1	0.0204	1.000	1.000
315	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(3), AGPS(1), CDS1(2), CDS2(1), CHAT(7), CHKA(1), CHKB(1), CLC(2), CPT1B(3), DGKB(6), DGKD(2), DGKE(1), DGKG(2), DGKH(6), DGKZ(1), ETNK1(1), GPD1(3), LGALS13(2), PAFAH1B1(1), PCYT1A(2), PCYT1B(3), PISD(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), PLCB2(2), PLCG1(1), PLCG2(11), PPAP2B(4), PPAP2C(2)	2280980	91	27	89	38	66	9	2	6	8	0	0.0251	1.000	1.000
316	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(5), ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH5(1), ADH6(2), ADH7(1), ADHFE1(2), ALDH1A3(1), ALDH3A1(2), ALDH3B1(1), ALDH3B2(2), AOC3(4), AOX1(5), CARM1(2), COMT(2), DBH(3), DCT(1), DDC(5), ECH1(1), ESCO2(2), FAH(1), GOT2(1), HGD(1), MAOB(6), METTL2B(2), MYST3(1), MYST4(1), NAT6(1), PNMT(2), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(3), SH3GLB1(1), TAT(2), TH(3), TPO(11), TYR(3), TYRP1(4)	2706256	119	27	118	60	83	14	7	9	6	0	0.232	1.000	1.000
317	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(6), ALPP(2), ALPPL2(6), ASCC3(6), ATP13A2(4), DDX18(1), DDX4(5), DDX41(2), DDX50(4), DDX51(2), DDX52(2), DDX54(1), DDX55(1), DDX56(1), ENTPD7(1), EP400(5), GGH(1), IFIH1(2), MOV10L1(4), NUDT5(1), QDPR(2), RAD54B(1), RUVBL2(2), SETX(1), SKIV2L2(1), SMARCA2(4)	2850362	70	27	69	27	51	3	4	5	7	0	0.0559	1.000	1.000
318	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	66	ACAA1(2), ACADL(3), ACADM(1), ACOX1(1), ACOX2(3), ACOX3(2), ACSL1(1), ACSL3(2), ACSL4(2), ACSL5(9), ACSL6(4), ADIPOQ(1), ANGPTL4(3), APOA1(1), APOA5(2), CD36(2), CPT1A(1), CPT1B(3), CPT1C(1), CYP27A1(1), CYP4A11(5), CYP4A22(5), CYP7A1(3), CYP8B1(5), EHHADH(1), FABP1(2), FABP4(1), FADS2(1), GK(3), GK2(14), HMGCS2(7), LPL(1), ME1(4), MMP1(4), OLR1(1), PCK1(8), PDPK1(2), PLTP(1), PPARA(1), PPARD(1), PPARG(2), RXRA(2), RXRB(2), RXRG(2), SCP2(1), SLC27A1(2), SLC27A2(2), SLC27A5(1), SORBS1(2), UBC(2), UCP1(1)	2936656	134	27	131	77	94	8	7	12	13	0	0.457	1.000	1.000
319	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(1), ATM(2), ATR(8), BAI1(6), BAX(2), CASP8(1), CASP9(2), CCNB3(9), CCND1(1), CCND2(1), CCNE1(1), CCNE2(3), CDK4(2), CDK6(1), CDKN1A(1), FAS(1), GTSE1(4), IGFBP3(1), PTEN(1), RFWD2(3), SERPINB5(3), SERPINE1(2), SESN2(2), SESN3(1), SFN(1), STEAP3(2), THBS1(10), TP73(2), TSC2(3)	2892347	77	27	77	30	52	7	7	5	6	0	0.0834	1.000	1.000
320	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(7), AR(2), ESR1(2), ESR2(2), ESRRA(1), HNF4A(7), NPM1(1), NR1D2(1), NR1H2(1), NR1I2(1), NR1I3(2), NR2C2(2), NR2F1(2), NR2F2(1), NR3C1(3), NR5A1(2), NR5A2(7), PGR(6), PPARA(1), PPARD(1), PPARG(2), RARA(1), RARB(2), RARG(1), ROR1(6), RORA(1), RORC(1), RXRA(2), RXRB(2), RXRG(2), THRB(4)	1899976	76	27	75	41	59	2	1	7	7	0	0.345	1.000	1.000
321	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	32	AKT2(1), AKT3(2), BCR(5), BTK(4), CD19(1), DAPP1(3), FLOT1(1), GAB1(1), ITPR1(8), ITPR2(4), ITPR3(1), LYN(2), NR0B2(1), PDK1(1), PIK3CA(3), PLCG2(11), PPP1R13B(2), PREX1(2), PTEN(1), PTPRC(4), RPS6KA1(3), RPS6KB1(1), SAG(3), SYK(4), TEC(2), VAV1(2)	2487679	73	27	73	50	53	6	5	3	6	0	0.733	1.000	1.000
322	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT2(1), AKT3(2), BCR(5), BLNK(4), BTK(4), CD19(1), DAG1(2), EPHB2(8), ITPKB(2), LYN(2), MAPK1(2), NFAT5(2), NFKB1(4), NFKBIA(1), NFKBIB(1), NFKBIL2(1), PI3(1), PIK3CA(3), PIK3CD(2), PLCG2(11), PPP1R13B(2), RAF1(3), SERPINA4(5), SHC1(1), SOS1(3), SOS2(5), SYK(4), VAV1(2)	2415720	84	27	83	50	59	13	4	2	6	0	0.510	1.000	1.000
323	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(2), CD28(1), CD3D(2), CTLA4(1), DAG1(2), EPHB2(8), FBXW7(4), GRAP2(1), ITK(8), ITPKB(2), LCK(3), LCP2(3), MAPK1(2), NFAT5(2), NFKB1(4), NFKBIA(1), NFKBIB(1), NFKBIL2(1), PAK2(2), PAK3(4), PAK4(2), PAK6(1), PAK7(15), PLCG1(1), PTPRC(4), RAF1(3), RASGRP1(2), RASGRP2(2), RASGRP3(3), RASGRP4(4), SOS1(3), SOS2(5), VAV1(2), ZAP70(2)	2534594	103	27	100	43	74	8	5	4	12	0	0.0503	1.000	1.000
324	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(5), ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH6(2), ADH7(1), ADHFE1(2), ALDH1A3(1), ALDH3A1(2), ALDH3B1(1), ALDH3B2(2), AOC3(4), AOX1(5), COMT(2), DBH(3), DCT(1), DDC(5), FAH(1), GOT2(1), HGD(1), MAOB(6), PNMT(2), TAT(2), TH(3), TPO(11), TYR(3)	1442252	94	27	93	45	64	11	6	7	6	0	0.0843	1.000	1.000
325	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGT(2), AGTR1(2), AGTR2(1), CMA1(1), COL4A1(12), COL4A2(8), COL4A3(11), COL4A4(23), COL4A5(13), COL4A6(14), REN(1)	1146701	89	26	86	23	71	5	3	9	1	0	0.337	1.000	1.000
326	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(2), ACAA2(1), ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH6(2), ADH7(1), ADHFE1(2), AKR1C4(4), AKR1D1(6), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), BAAT(4), CEL(2), CYP27A1(1), CYP7A1(3), HADHB(2), SOAT2(1), SRD5A1(1), SRD5A2(2)	1064634	74	26	73	30	43	10	4	8	9	0	0.0627	1.000	1.000
327	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	12	C1R(2), C1S(3), C2(2), C3(14), C5(2), C6(18), C9(5), MASP1(2), MASP2(3), MBL2(1)	844635	52	26	50	32	40	3	0	5	4	0	0.670	1.000	1.000
328	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	B4GALT1(1), B4GALT2(1), G6PC(4), GALT(1), GCK(2), GLB1(2), HK2(5), HK3(3), LALBA(4), LCT(13), MGAM(47), PGM1(1), PGM3(1)	1486817	85	26	84	40	58	14	2	8	3	0	0.0696	1.000	1.000
329	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(24), GABBR1(3), GPRC5A(1), GPRC5B(3), GPRC5C(2), GRM1(7), GRM2(3), GRM3(18), GRM4(8), GRM5(4), GRM7(9), GRM8(12)	951858	94	26	89	47	66	6	6	8	8	0	0.0126	1.000	1.000
330	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	UGP2(1), UGT1A1(1), UGT1A10(7), UGT1A3(3), UGT1A4(3), UGT1A5(4), UGT1A6(2), UGT1A7(5), UGT1A8(2), UGT1A9(5), UGT2A1(9), UGT2A3(5), UGT2B10(9), UGT2B11(7), UGT2B15(3), UGT2B28(8), UGT2B4(9), UGT2B7(5)	1233289	88	26	87	36	64	10	1	5	7	1	0.0734	1.000	1.000
331	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B10(2), B4GALT1(1), B4GALT2(1), G6PC(4), GALT(1), GANC(1), GCK(2), GLB1(2), HK2(5), HK3(3), LALBA(4), LCT(13), MGAM(47), PFKL(2), PGM1(1), PGM3(1), RDH11(1), RDH12(1), RDH13(1), UGP2(1)	1763593	94	26	93	48	65	14	2	8	5	0	0.120	1.000	1.000
332	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(2), ACAA2(1), ACAD9(1), ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH5(1), ADH6(2), ADH7(1), ADHFE1(2), AKR1B10(2), AKR1C4(4), AKR1D1(6), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), BAAT(4), CEL(2), CYP27A1(1), CYP7A1(3), HADHB(2), LIPA(1), RDH11(1), RDH12(1), RDH13(1), SLC27A5(1), SOAT2(1), SRD5A1(1), SRD5A2(2)	1449444	81	26	80	42	49	10	4	8	10	0	0.265	1.000	1.000
333	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(2), AASS(1), AKR1B10(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), BBOX1(1), DOT1L(4), EHHADH(1), EHMT1(2), GCDH(1), HADHA(1), HSD17B4(1), NSD1(5), OGDH(3), OGDHL(9), PIPOX(2), PLOD1(1), PLOD2(4), PLOD3(2), RDH11(1), RDH12(1), RDH13(1), SETD1A(8), SETD7(2), SETDB1(4), SUV39H1(1)	2644141	70	26	70	32	42	7	3	11	7	0	0.254	1.000	1.000
334	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(2), AANAT(1), ABP1(5), ACMSD(5), AFMID(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), AOC3(4), AOX1(5), ASMT(3), CARM1(2), CAT(1), CYP1A1(2), CYP1A2(2), CYP1B1(1), DDC(5), EHHADH(1), GCDH(1), HAAO(2), HADHA(1), HSD17B4(1), INMT(4), KMO(5), KYNU(2), LNX1(6), MAOB(6), METTL2B(2), NFX1(1), OGDH(3), OGDHL(9), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(3), TDO2(1), TPH1(1), TPH2(8), WARS(3), WARS2(1)	2763736	117	26	116	55	77	11	7	13	9	0	0.104	1.000	1.000
335	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(3), CDS1(2), CDS2(1), CHAT(7), CHKA(1), CHKB(1), DGKB(6), DGKD(2), DGKE(1), DGKG(2), DGKH(6), DGKI(6), DGKZ(1), ESCO2(2), ETNK1(1), GPD1(3), GPD1L(1), MYST3(1), MYST4(1), NAT6(1), PCYT1A(2), PCYT1B(3), PISD(1), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), PLD1(3), PLD2(2), PPAP2B(4), PPAP2C(2), PTDSS2(1), SH3GLB1(1)	2979095	89	26	87	44	58	12	2	7	10	0	0.320	1.000	1.000
336	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(6), ACACB(5), ACOT12(3), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), DLAT(1), DLD(1), HAGH(1), LDHAL6B(1), LDHC(3), LDHD(1), MDH2(2), ME1(4), ME3(2), PC(1), PCK1(8), PDHA2(6), PKLR(4), PKM2(1)	2137938	60	26	60	27	37	6	6	9	2	0	0.187	1.000	1.000
337	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(1), ALAS2(1), BLVRA(1), COX10(1), COX15(2), CP(4), CPOX(2), EPRS(3), FTH1(1), FTMT(2), MMAB(1), PPOX(1), UGT1A1(1), UGT1A10(7), UGT1A3(3), UGT1A4(3), UGT1A5(4), UGT1A6(2), UGT1A7(5), UGT1A8(2), UGT1A9(5), UGT2A1(9), UGT2A3(5), UGT2B10(9), UGT2B11(7), UGT2B15(3), UGT2B28(8), UGT2B4(9), UGT2B7(5)	1913851	107	26	106	39	79	10	3	6	8	1	0.0133	1.000	1.000
338	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), FUCA1(2), GALNS(2), GLB1(2), GNS(1), HEXA(2), HEXB(2), HGSNAT(1), HPSE(2), HPSE2(2), HYAL1(1), IDS(5), IDUA(1), LCT(13), MAN2B1(2), MAN2B2(4), MAN2C1(1), MANBA(3), NAGLU(1), NEU1(2), NEU2(2), NEU3(1), SPAM1(8)	1559857	61	26	61	31	44	5	3	7	2	0	0.339	1.000	1.000
339	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	79	AIFM1(1), AKT2(1), AKT3(2), APAF1(1), ATM(2), BAX(2), BIRC3(1), CAPN1(1), CAPN2(1), CASP10(1), CASP7(2), CASP8(1), CASP9(2), CFLAR(1), CHP(1), CHUK(1), CSF2RB(3), DFFB(1), FAS(1), FASLG(2), IL1A(3), IL1B(1), IL1R1(3), IL1RAP(2), IRAK2(4), IRAK3(1), IRAK4(1), MAP3K14(2), MYD88(2), NFKB1(4), NFKBIA(1), NTRK1(2), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PPP3R2(1), PRKACA(1), PRKACB(1), PRKAR2B(3), RELA(1), TNFRSF10A(2), TNFRSF10C(1), TNFRSF10D(4), TNFRSF1A(1), TNFSF10(1)	3758385	87	26	87	72	58	9	5	9	6	0	0.994	1.000	1.000
340	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	67	AKT2(1), AKT3(2), CASP9(2), CDC42(1), CHP(1), HRAS(2), KDR(8), KRAS(1), MAPK1(2), MAPK13(1), MAPK14(3), MAPK3(1), MAPKAPK2(2), MAPKAPK3(1), NFAT5(2), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), NOS3(2), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), PLCG1(1), PLCG2(11), PPP3R2(1), PRKCA(5), PRKCG(4), PTGS2(3), PTK2(2), RAC2(1), RAF1(3), SH2D2A(1), SHC2(3), SPHK2(3), SRC(1), VEGFA(2)	3260312	121	26	121	59	83	10	5	12	11	0	0.141	1.000	1.000
341	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	72	AKT2(1), AKT3(2), BTK(4), FCER1A(2), FYN(1), GAB2(1), HRAS(2), IL4(1), INPP5D(13), KRAS(1), LCP2(3), LYN(2), MAP2K3(2), MAP2K7(2), MAPK1(2), MAPK10(5), MAPK13(1), MAPK14(3), MAPK3(1), MAPK9(1), MS4A2(5), PDK1(1), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), PLCG1(1), PLCG2(11), PRKCA(5), PRKCD(2), PRKCE(2), RAC2(1), RAF1(3), SOS1(3), SOS2(5), SYK(4), VAV1(2), VAV3(4)	3262445	133	26	133	57	92	13	5	11	12	0	0.0306	1.000	1.000
342	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(2), ATP6AP1(1), ATP6V0A1(4), ATP6V0A2(1), ATP6V0A4(7), ATP6V0D2(1), ATP6V1B2(2), ATP6V1C2(4), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(2), CDC42(1), CHUK(1), EGFR(6), IGSF5(2), JAM2(3), LYN(2), MAP3K14(2), MAPK10(5), MAPK13(1), MAPK14(3), MAPK9(1), MET(7), NFKB1(4), NFKBIA(1), NOD1(5), PLCG1(1), PLCG2(11), PTPN11(5), PTPRZ1(7), RELA(1), SRC(1), TJP1(2)	3194590	104	26	103	59	71	8	3	10	12	0	0.537	1.000	1.000
343	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP1(1), INPP4B(1), INPP5A(2), INPPL1(7), ITPKB(2), MIOX(1), OCRL(2), PIK3C2A(1), PIK3C2B(2), PIK3C2G(13), PIK3CA(3), PIK3CB(2), PIK3CG(7), PLCB1(18), PLCB2(2), PLCB4(21), PLCD1(1), PLCG1(1), PLCG2(11)	2036995	98	26	96	41	77	7	3	3	7	1	0.0264	1.000	1.000
344	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(1), DAXX(5), EGF(4), EGFR(6), ETS1(2), ETS2(2), HRAS(2), MAP2K3(2), MAP2K7(2), MAP3K14(2), MAP3K5(7), MAPK1(2), MAPK13(1), MAPK14(3), MAPK3(1), NFKB1(4), NFKBIA(1), PRKCA(5), PRKCD(2), PRKCE(2), PRKCG(4), PRKCH(2), PRKCQ(5), RAF1(3), RELA(1), SP1(2), TNFRSF1A(1), TNFRSF1B(2)	2234921	76	26	75	43	51	7	1	12	5	0	0.595	1.000	1.000
345	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	15	C3(14), C5(2), C6(18), IL1A(3), ITGA4(13), ITGAL(8), ITGB1(2), ITGB2(6), SELP(10), SELPLG(2), VCAM1(4)	1058059	82	26	80	33	62	1	5	6	8	0	0.0461	1.000	1.000
346	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CDC40(4), CLK2(1), COL2A1(5), CPSF1(1), CPSF3(1), CSTF1(3), CSTF2(1), CSTF2T(1), CSTF3(3), DDIT3(1), DDX20(1), DHX15(2), DHX16(1), DHX38(3), DHX8(1), DHX9(2), DICER1(5), GIPC1(1), LOC440563(5), METTL3(1), NONO(1), NXF1(1), PAPOLA(3), POLR2A(1), PPM1G(1), PRPF18(2), PRPF3(1), PRPF4B(2), PRPF8(4), PTBP1(1), PTBP2(1), RBM5(3), RNMT(5), SF3A1(1), SF3A2(3), SF3A3(2), SF3B1(6), SF3B2(2), SF3B4(2), SFRS12(2), SFRS14(1), SFRS16(1), SFRS7(1), SFRS8(2), SNRPA(1), SNRPB(2), SNRPB2(1), SNRPE(1), SNRPN(2), SNURF(2), SRPK1(1), SRRM1(1), SUPT5H(2), U2AF2(2)	4855386	107	26	106	50	68	6	7	15	11	0	0.555	1.000	1.000
347	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	AGT(2), CALM1(1), CAMK1G(2), CAMK4(3), CREBBP(4), EDN1(2), ELSPBP1(1), F2(3), FKBP1A(1), GATA4(1), GSK3B(1), HAND1(1), HAND2(1), HRAS(2), LIF(1), MAPK1(2), MAPK14(3), MAPK3(1), MEF2C(1), MYH2(22), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), PIK3CA(3), PRKACB(1), PRKAR2B(3), RAF1(3), RPS6KB1(1), SYT1(4)	2321243	84	26	83	63	58	6	6	6	8	0	0.967	1.000	1.000
348	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), DLG4(3), GRIN1(3), GRIN2A(30), GRIN2B(11), GRIN2C(2), GRIN2D(2), NOS1(20), PRKACB(1), PRKAR2B(3), PRKCA(5), SYT1(4)	1162525	85	26	84	56	60	10	3	5	7	0	0.529	1.000	1.000
349	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(6), ADH5(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), DLAT(1), DLD(1), HAGH(1), LDHC(3), LDHD(1), MDH2(2), ME1(4), ME3(2), PC(1), PCK1(8), PDHA2(6), PKLR(4), PKM2(1)	1689107	54	26	54	22	37	4	4	7	2	0	0.116	1.000	1.000
350	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT2(1), AKT3(2), IARS(5), IL13RA1(2), IL4(1), IL4R(3), INPP5D(13), JAK1(1), JAK2(1), NR0B2(1), PI3(1), PIK3CA(3), PPP1R13B(2), RPS6KB1(1), SERPINA4(5), SHC1(1), SOS1(3), SOS2(5), SRC(1), STAT6(4), TYK2(3)	1683378	59	26	59	26	35	7	3	7	7	0	0.296	1.000	1.000
351	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	ATF2(1), CDC42(1), DLD(1), DUSP10(3), GAB1(1), GCK(2), IL1R1(3), MAP2K5(1), MAP2K7(2), MAP3K10(2), MAP3K11(3), MAP3K12(1), MAP3K13(2), MAP3K2(1), MAP3K3(1), MAP3K4(4), MAP3K5(7), MAP3K7(1), MAP3K9(8), MAPK10(5), MAPK7(2), MAPK9(1), MYEF2(1), NFATC3(2), NR2C2(2), PAPPA(14), SHC1(1), TRAF6(2), ZAK(3)	2260902	78	26	76	28	55	9	2	9	3	0	0.0849	1.000	1.000
352	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT2(1), AKT3(2), APC(5), AXIN1(4), AXIN2(2), CER1(6), CTNNB1(3), DACT1(3), DKK2(4), DKK3(2), DKK4(1), GSK3B(1), LRP1(13), MVP(3), NKD1(1), NKD2(1), PIN1(1), PTPRA(2), SENP2(3), SFRP1(1), TSHB(3), WIF1(4)	1826180	66	26	65	31	38	10	4	8	6	0	0.354	1.000	1.000
353	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(5), ATF2(1), AXIN1(4), BMP10(2), BMP2(1), BMP4(1), BMP5(9), BMPR2(1), CHRD(7), CTNNB1(3), FZD1(1), GATA4(1), GSK3B(1), MAP3K7(1), MEF2C(1), MYL2(2), NOG(1), NPPB(1), TGFBR2(2), TGFBR3(2)	1655691	47	25	47	21	30	5	3	5	4	0	0.407	1.000	1.000
354	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	9	C1R(2), C1S(3), C2(2), C3(14), C5(2), C6(18), C9(5)	670204	46	25	44	28	35	2	0	5	4	0	0.670	1.000	1.000
355	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(6), ELK1(1), GNAS(4), HRAS(2), IGF1R(1), ITGB1(2), MAPK1(2), MAPK3(1), MKNK1(1), MYC(2), NGFR(5), PDGFRA(9), PTPRR(5), RAF1(3), RPS6KA1(3), RPS6KA5(1), SHC1(1), SOS1(3), SRC(1), STAT3(1)	1501148	54	25	54	31	32	10	1	8	3	0	0.595	1.000	1.000
356	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CALM1(1), CAMK1G(2), ELK1(1), FPR1(4), GNA15(2), HRAS(2), MAP2K3(2), MAPK1(2), MAPK14(3), MAPK3(1), NCF2(2), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), NFKB1(4), NFKBIA(1), PIK3C2G(13), PLCB1(18), RAF1(3), RELA(1), SYT1(4)	1717468	80	25	78	32	61	5	2	5	7	0	0.0694	1.000	1.000
357	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(2), CAD(5), CANT1(4), CDA(1), CTPS2(1), DCTD(1), DHODH(1), DPYD(18), DPYS(6), ENTPD1(2), ENTPD4(1), ENTPD6(1), NME6(2), NME7(2), NT5C1A(2), NT5C1B(6), NT5C3(2), NT5E(1), NT5M(1), POLA2(2), POLD1(1), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLR1A(5), POLR1B(4), POLR2A(1), POLR2B(6), POLR2E(1), POLR3A(2), POLR3B(4), POLR3G(1), POLR3GL(1), PRIM2(3), RRM1(1), TXNRD1(3), TXNRD2(2), UPB1(1)	3695932	106	25	105	48	71	7	4	14	10	0	0.139	1.000	1.000
358	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(5), AGXT(1), AGXT2(3), AKR1B10(2), ALAS2(1), AOC3(4), BHMT(1), CBS(2), CHDH(3), CHKA(1), CHKB(1), DAO(4), DLD(1), DMGDH(1), GAMT(2), GARS(2), GATM(1), GCAT(2), GLDC(1), MAOB(6), PHGDH(2), PIPOX(2), PISD(1), PSAT1(1), RDH11(1), RDH12(1), RDH13(1), SARDH(9), SARS(1), SARS2(1), SDS(1), TARS2(2)	1951856	67	25	67	42	47	6	5	4	5	0	0.579	1.000	1.000
359	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG2(1), ASL(1), ASS1(1), CKMT2(1), CPS1(8), DAO(4), EPRS(3), GAMT(2), GATM(1), GLUD2(2), GOT2(1), LAP3(1), NOS1(20), NOS3(2), OAT(2), P4HA1(4), P4HA2(1), P4HA3(4), PYCR1(1), RARS(4)	1636347	65	25	65	37	44	7	1	5	8	0	0.462	1.000	1.000
360	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	C1GALT1(1), C1GALT1C1(1), GALNT1(1), GALNT11(1), GALNT12(1), GALNT13(8), GALNT14(8), GALNT2(1), GALNT3(1), GALNT4(2), GALNT5(3), GALNT6(4), GALNT7(2), GALNT8(5), GALNT9(1), GALNTL1(2), GALNTL2(10), GALNTL4(3), GALNTL5(2), GCNT1(2), GCNT4(3), OGT(2), ST3GAL1(2), ST6GALNAC1(1), WBSCR17(11)	1472587	78	25	76	45	59	5	2	6	6	0	0.616	1.000	1.000
361	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(1), ARSE(3), B4GALT6(1), DEGS2(3), ENPP7(1), GAL3ST1(2), GALC(2), GLB1(2), LCT(13), NEU1(2), NEU2(2), NEU3(1), PPAP2B(4), PPAP2C(2), SGMS1(3), SGPP2(1), SMPD2(1), SMPD3(1), SMPD4(2), SPHK2(3), SPTLC1(1), SPTLC2(1), UGCG(1), UGT8(1)	1618726	54	25	53	31	38	4	1	6	5	0	0.512	1.000	1.000
362	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(1), ABAT(3), ACADS(2), ACSM1(6), AKR1B10(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH5A1(3), ALDH7A1(1), BDH1(1), EHHADH(1), GAD1(4), GAD2(1), HADHA(1), HMGCL(3), HMGCS2(7), HSD17B4(1), ILVBL(2), L2HGDH(2), OXCT1(1), PDHA2(6), PLA1A(3), PRDX6(1), RDH11(1), RDH12(1), RDH13(1)	1859635	64	25	63	43	43	8	1	8	4	0	0.845	1.000	1.000
363	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(1), ACTN2(6), ACTN3(3), BCAR1(2), BCR(5), CAPN1(1), CAV1(1), FYN(1), HRAS(2), ITGA1(11), ITGB1(2), MAPK1(2), MAPK3(1), PPP1R12B(3), PTK2(2), RAF1(3), RAP1A(1), ROCK1(2), SHC1(1), SOS1(3), SRC(1), TLN1(5), VCL(2), ZYX(2)	2134252	63	25	62	28	41	9	2	6	4	1	0.114	1.000	1.000
364	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(5), CANT1(4), CDA(1), CTPS2(1), DCTD(1), DHODH(1), DPYD(18), DPYS(6), ENTPD1(2), NT5E(1), NT5M(1), POLD1(1), POLD2(1), POLE(6), POLL(4), POLQ(9), POLR1B(4), POLR2A(1), POLR2B(6), POLR2E(1), POLRMT(1), RRM1(1), TXNRD1(3), UNG(1), UPB1(1)	2620655	81	25	80	27	51	6	2	13	9	0	0.0101	1.000	1.000
365	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(8), CDR1(3), DGKI(6), IL6ST(1), PIGK(1), RPL10(2), RPL15(1), RPL18(1), RPL18A(1), RPL19(1), RPL26(1), RPL35(1), RPL3L(2), RPL4(1), RPL5(1), RPS10(1), RPS15(1), RPS18(1), RPS27(1), RPS6KA1(3), RPS6KA6(3), RPS6KB1(1), RPS6KB2(1), RPS7(1), SLC36A2(2), TBC1D10C(2), UBC(2)	2367132	50	25	48	40	34	5	2	6	3	0	0.970	1.000	1.000
366	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	APC(5), AR(2), DAG1(2), EGFR(6), GNA11(1), GNA15(2), GNAQ(1), ITPKB(2), ITPR1(8), ITPR2(4), ITPR3(1), KCNJ3(8), KCNJ5(3), MAPK1(2), MAPK10(5), MAPK14(3), PHKA2(2), PIK3CA(3), PIK3CD(2), RAF1(3), SRC(1)	2360676	66	25	66	46	43	6	7	7	3	0	0.864	1.000	1.000
367	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT2(1), AKT3(2), ARHGEF11(7), CDC42(1), DLG4(3), LPA(18), MAP3K5(7), NFKB1(4), NFKBIA(1), NFKBIB(1), NFKBIL2(1), PDK1(1), PHKA2(2), PI3(1), PIK3CB(2), PLD1(3), PLD2(2), PTK2(2), ROCK1(2), ROCK2(4), SERPINA4(5), TBXA2R(2)	2238447	72	25	71	34	46	8	2	9	7	0	0.316	1.000	1.000
368	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	4	C3(14), C5(2), C6(18), C9(5)	447898	39	24	37	19	31	1	0	4	3	0	0.371	1.000	1.000
369	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(1), BAX(2), BIRC3(1), CASP2(1), CASP7(2), CASP8(1), CASP9(2), FAS(1), FASLG(2), MAP3K14(2), MAPK10(5), MYC(2), NFKB1(4), NFKBIA(1), PARP1(1), PRF1(2), RELA(1), TNFRSF1A(1), TNFRSF1B(2), TNFSF10(1), TRAF1(2)	1664817	37	24	37	17	27	3	2	3	2	0	0.378	1.000	1.000
370	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(3), ABP1(5), ACADL(3), ACADM(1), ACADSB(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), AOC3(4), CNDP1(2), DPYD(18), DPYS(6), EHHADH(1), GAD1(4), GAD2(1), HADHA(1), SDS(1), SMS(1), UPB1(1)	1328470	65	24	64	36	47	5	2	7	4	0	0.425	1.000	1.000
371	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(2), AGTR2(1), CALM1(1), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), F2(3), FYN(1), GNA11(1), HRAS(2), JAK2(1), MAPK1(2), MAPK14(3), MAPK3(1), MAPT(3), MYLK(11), PLCG1(1), PRKCA(5), PTK2B(2), RAF1(3), SHC1(1), SOS1(3), STAT1(3), STAT3(1), STAT5A(1), SYT1(4)	1896893	62	24	61	37	44	8	1	6	3	0	0.518	1.000	1.000
372	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(2), CSF1R(3), EGF(4), EGFR(6), MET(7), PDGFRA(9), PRKCA(5), SH3GLB1(1), SH3GLB2(1), SH3KBP1(2), SRC(1)	888298	41	24	41	29	24	4	1	7	5	0	0.916	1.000	1.000
373	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(3), CALCR(6), CALCRL(6), CRHR1(2), CRHR2(1), ELTD1(7), EMR1(8), EMR2(2), GIPR(1), GLP1R(3), GLP2R(7), GPR64(1), LPHN1(1), LPHN2(13), LPHN3(8), SCTR(3), VIPR1(1), VIPR2(3)	1205045	76	24	71	35	61	6	2	4	3	0	0.0266	1.000	1.000
374	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(1), APAF1(1), ARHGDIB(1), BIRC3(1), CASP2(1), CASP7(2), CASP8(1), CASP9(2), CFLAR(1), CHUK(1), DAXX(5), DFFB(1), GSN(2), LMNA(1), MAP2K7(2), MAP3K14(2), MAP3K5(7), NFKB1(4), NFKBIA(1), NUMA1(2), PAK2(2), PRKCD(2), PRKDC(6), PTK2(2), RB1(2), RELA(1), SPTAN1(2), TNFRSF1A(1), TNFRSF1B(2), TRAF1(2)	3154582	61	24	60	30	40	6	1	7	6	1	0.409	1.000	1.000
375	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(8), ATP4A(2), ATP5B(1), ATP5C1(1), ATP5F1(2), ATP5G2(1), ATP5H(1), ATP5O(1), ATP6AP1(1), ATP6V0A1(4), ATP6V0A2(1), ATP6V0A4(7), ATP6V0D2(1), ATP6V1B2(2), ATP6V1C2(4), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(2), COX10(1), COX15(2), COX4I2(1), CYC1(1), NDUFA10(2), NDUFA13(3), NDUFAB1(1), NDUFB3(1), NDUFB5(2), NDUFS2(1), NDUFS4(1), NDUFS5(1), NDUFS6(1), NDUFS7(1), NDUFS8(3), SDHA(1), SDHC(1), SDHD(1), UQCRC1(1), UQCRC2(1), UQCRFS1(1)	2560283	75	24	75	26	49	4	0	11	11	0	0.0271	1.000	1.000
376	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(5), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH3B1(1), ALDH3B2(2), ALDH7A1(1), AOC3(4), ASPA(1), CARM1(2), CNDP1(2), DDC(5), FTCD(1), HAL(3), HDC(5), MAOB(6), METTL2B(2), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(3), PRPS2(1), UROC1(4)	1800600	63	24	62	42	39	8	4	6	6	0	0.704	1.000	1.000
377	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(3), ABP1(5), ACADM(1), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), AOC3(4), CNDP1(2), DPYD(18), DPYS(6), EHHADH(1), GAD1(4), GAD2(1), HADHA(1), HIBCH(1), SMS(1), UPB1(1)	1235792	59	24	58	33	40	5	2	8	4	0	0.454	1.000	1.000
378	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(2), ALOX15(4), ALOX5(4), CYP1A2(2), CYP2C18(10), CYP2C19(7), CYP2C8(11), CYP2C9(12), CYP2E1(5), CYP2J2(2), CYP3A4(3), CYP3A43(4), CYP3A5(2), CYP3A7(7), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(2), PLA2G3(7), PLA2G4A(1), PLA2G5(1), PLA2G6(2), RDH11(1), RDH12(1), RDH13(1)	1091299	95	24	93	49	74	3	3	4	11	0	0.0976	1.000	1.000
379	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(1), CARS(3), CARS2(1), DARS(2), EPRS(3), FARS2(2), FARSA(2), FARSB(3), GARS(2), IARS(5), IARS2(4), KARS(2), LARS(1), MARS2(2), NARS(1), RARS(4), SARS(1), SARS2(1), TARS2(2), VARS(5), WARS(3), WARS2(1), YARS(1), YARS2(2)	2495950	55	24	53	33	41	3	2	3	6	0	0.689	1.000	1.000
380	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(3), B3GALNT1(1), B3GALT1(1), B3GNT3(1), B3GNT4(1), B4GALNT1(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), B4GALT6(1), FUT2(1), FUT3(2), FUT5(1), FUT6(1), FUT9(7), PIGC(2), PIGF(1), PIGG(2), PIGK(1), PIGL(1), PIGN(1), PIGO(3), PIGQ(2), PIGS(1), PIGU(1), PIGV(2), PIGX(1), PIGZ(1), ST3GAL1(2), ST3GAL6(1), ST6GALNAC3(2), ST6GALNAC5(2), ST6GALNAC6(1), ST8SIA1(1), ST8SIA5(5), UGCG(1)	2203500	58	24	58	43	35	6	6	6	5	0	0.848	1.000	1.000
381	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	43	AKT2(1), AKT3(2), CAB39(1), EIF4B(2), MAPK1(2), MAPK3(1), PDPK1(2), PIK3CA(3), PIK3CB(2), PIK3CD(2), PIK3CG(7), PIK3R5(3), PRKAA1(1), PRKAA2(4), RICTOR(1), RPS6KA1(3), RPS6KA6(3), RPS6KB1(1), RPS6KB2(1), STK11(1), TSC1(1), TSC2(3), ULK1(2), ULK2(2), VEGFA(2), VEGFC(7)	2342607	60	24	57	33	42	6	2	3	7	0	0.505	1.000	1.000
382	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	APH1A(1), CREBBP(4), DLL1(1), DLL3(1), DLL4(3), DTX1(5), DTX2(1), DTX3(2), DTX4(1), DVL3(1), EP300(7), JAG1(2), JAG2(1), MAML1(1), MAML2(3), MAML3(3), MFNG(4), NCOR2(9), NCSTN(2), NOTCH1(1), NOTCH2(4), NOTCH3(5), NOTCH4(14), NUMBL(3), RBPJ(2), RBPJL(1)	3146825	82	24	82	45	57	7	1	11	6	0	0.697	1.000	1.000
383	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	CRK(1), DOCK1(5), ELK1(1), GAB1(1), HGF(4), HRAS(2), ITGA1(11), ITGB1(2), MAP4K1(4), MAPK1(2), MAPK3(1), MET(7), PIK3CA(3), PTEN(1), PTK2(2), PTK2B(2), PTPN11(5), RAF1(3), RAP1A(1), RAP1B(1), SOS1(3), SRC(1), STAT3(1)	2003965	64	24	62	30	42	10	0	6	6	0	0.443	1.000	1.000
384	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(1), APOA1(1), CD36(2), CPT1B(3), CREBBP(4), EHHADH(1), EP300(7), FABP1(2), HSD17B4(1), LPL(1), MAPK1(2), MAPK3(1), ME1(4), MYC(2), NCOA1(1), NCOR1(4), NCOR2(9), NFKBIA(1), NR0B2(1), NR2F1(2), NRIP1(2), PIK3CA(3), PPARA(1), PRKACB(1), PRKAR2B(3), PRKCA(5), PTGS2(3), RB1(2), RELA(1), RXRA(2), SP1(2), STAT5A(1), STAT5B(1)	2897794	77	24	77	38	55	5	4	6	6	1	0.416	1.000	1.000
385	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(1), BCR(5), BLNK(4), ELK1(1), HRAS(2), LYN(2), MAPK1(2), MAPK3(1), MAPK8IP3(3), PAPPA(14), RPS6KA1(3), SHC1(1), SOS1(3), SYK(4), VAV1(2), VAV3(4)	1436723	52	24	51	33	39	7	0	3	3	0	0.689	1.000	1.000
386	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	ADRB1(3), APC(5), DAG1(2), DLG4(3), EPHB2(8), GNAQ(1), ITPR1(8), ITPR2(4), ITPR3(1), KCNJ3(8), KCNJ5(3), MAPK1(2), RYR1(18)	2067962	66	24	65	52	40	11	5	5	5	0	0.906	1.000	1.000
387	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	CDC42(1), CREB3(1), CREB5(2), DUSP10(3), EEF2K(4), ELK1(1), HSPB1(2), IL1R1(3), MAP2K3(2), MAP3K10(2), MAP3K4(4), MAP3K5(7), MAP3K7(1), MAPK1(2), MAPK13(1), MAPK14(3), MAPKAPK2(2), MKNK1(1), MYEF2(1), NFKB1(4), NR2C2(2), TRAF6(2)	1523119	51	24	50	23	29	5	1	10	6	0	0.324	1.000	1.000
388	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(1), EEF2K(4), EIF2AK1(1), EIF2AK2(2), EIF2AK3(2), EIF2B1(2), EIF2B3(1), EIF2B4(1), EIF4A2(2), EIF4G1(7), EIF4G3(6), EIF5B(1), ETF1(1), GSPT2(2), PABPC1(1), PABPC3(2), PAIP1(2), SLC35A4(2)	1992923	40	24	40	17	23	6	3	2	6	0	0.345	1.000	1.000
389	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BAX(2), BCL2A1(1), BCL2L2(2), CASP1(1), CASP10(1), CASP2(1), CASP7(2), CASP8(1), CASP9(2), CD40(1), CD40LG(1), DAXX(5), DFFB(1), FAS(1), FASLG(2), IKBKE(1), LTA(1), NFKB1(4), NFKBIA(1), NGFR(5), NR3C1(3), NTRK1(2), PTPN13(3), SFRS2IP(3), TNFRSF1A(1), TNFRSF1B(2), TRAF1(2), TRAF3(3), TRAF6(2)	1976246	58	23	58	29	39	7	1	7	4	0	0.494	1.000	1.000
390	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(4), CARM1(2), CCND1(1), CREBBP(4), EP300(7), ESR1(2), GRIP1(3), GTF2A1(1), GTF2E1(1), GTF2F1(1), HDAC3(3), HDAC4(2), HDAC5(4), HDAC6(1), MEF2C(1), NCOR2(9), NRIP1(2), PELP1(5), POLR2A(1), TBP(2)	2076223	56	23	56	23	44	0	4	4	4	0	0.185	1.000	1.000
391	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(5), AGXT(1), AGXT2(3), ALAS2(1), AOC3(4), BHMT(1), CBS(2), CHDH(3), CHKA(1), CHKB(1), CPT1B(3), DAO(4), DLD(1), DMGDH(1), GAMT(2), GARS(2), GATM(1), GCAT(2), GLDC(1), MAOB(6), PISD(1), PLCB2(2), PLCG1(1), PLCG2(11), SARDH(9), SARS(1)	1920397	70	23	70	40	51	6	6	4	3	0	0.343	1.000	1.000
392	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSD(1), ARSE(3), GAL3ST1(2), GALC(2), GLB1(2), LCT(13), NEU1(2), NEU2(2), NEU3(1), PPAP2B(4), PPAP2C(2), SMPD2(1), SPTLC1(1), SPTLC2(1), UGCG(1)	1093725	38	23	37	20	26	4	1	6	1	0	0.492	1.000	1.000
393	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(5), ALDH1A3(1), ALDH3A1(2), ALDH3B1(1), ALDH3B2(2), AOC3(4), DDC(5), EPX(4), ESCO2(2), GOT2(1), LPO(4), MAOB(6), MPO(2), MYST3(1), MYST4(1), NAT6(1), PRDX6(1), SH3GLB1(1), TAT(2), TPO(11)	1563008	57	23	57	36	37	8	4	5	3	0	0.670	1.000	1.000
394	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10(1), ALG10B(1), ALG13(2), ALG2(2), ALG3(1), ALG6(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), DAD1(1), DHDDS(1), DPM1(1), FUT8(2), MAN1A1(3), MAN1B1(1), MAN1C1(3), MGAT1(1), MGAT3(4), MGAT4A(2), MGAT5(1), MGAT5B(3), RFT1(2), RPN2(1), ST6GAL1(1), STT3B(1)	1932400	39	23	39	19	25	4	4	3	3	0	0.315	1.000	1.000
395	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GALNS(2), GLB1(2), GNS(1), HEXA(2), HEXB(2), HGSNAT(1), HPSE(2), HPSE2(2), HYAL1(1), IDS(5), IDUA(1), LCT(13), NAGLU(1), SPAM1(8)	928936	43	23	43	25	29	4	2	7	1	0	0.634	1.000	1.000
396	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(2), ANAPC2(3), ANAPC4(2), ANAPC5(2), BTRC(3), CDC20(1), CDC23(1), CDC27(5), CUL1(2), CUL2(3), CUL3(1), FBXW11(2), FBXW7(4), FZR1(2), ITCH(2), SMURF2(5), TCEB1(1), TCEB2(1), UBE2D3(1), UBE2E1(1), UBE2E2(1), VHL(2), WWP1(1), WWP2(3)	1820225	51	23	50	19	33	2	2	5	9	0	0.284	1.000	1.000
397	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPN1(1), CAPN2(1), CXCR3(1), EGF(4), EGFR(6), HRAS(2), ITGA1(11), ITGB1(2), MAPK1(2), MAPK3(1), MYL2(2), MYLK(11), PRKACB(1), PRKAR2B(3), PTK2(2), TLN1(5)	1480360	55	23	53	34	42	4	4	4	1	0	0.531	1.000	1.000
398	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(6), ARHGEF1(1), F2(3), F2R(2), F2RL3(1), GNA12(1), GNAQ(1), MAP3K7(1), PIK3CA(3), PLCB1(18), PPP1R12B(3), PRKCA(5), PTK2B(2), ROCK1(2)	1181634	49	23	48	26	38	5	2	3	1	0	0.429	1.000	1.000
399	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	UCHL1(2), UCHL3(1), UGT1A1(1), UGT1A10(7), UGT1A3(3), UGT1A4(3), UGT1A5(4), UGT1A6(2), UGT1A7(5), UGT1A8(2), UGT1A9(5), UGT2B15(3), UGT2B4(9)	805257	47	23	45	25	34	6	1	2	3	1	0.344	1.000	1.000
400	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), BLVRA(1), CP(4), CPOX(2), EPRS(3), PPOX(1), UGT1A1(1), UGT1A10(7), UGT1A3(3), UGT1A4(3), UGT1A5(4), UGT1A6(2), UGT1A7(5), UGT1A8(2), UGT1A9(5), UGT2B15(3), UGT2B4(9)	1257319	56	23	55	27	41	6	2	3	3	1	0.264	1.000	1.000
401	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP1(1), ARHGAP4(1), ARHGAP5(3), ARHGAP6(4), ARHGEF1(1), ARHGEF11(7), ARHGEF5(4), BAIAP2(2), DIAPH1(5), GSN(2), LIMK1(1), MYL2(2), MYLK(11), OPHN1(1), PIP5K1A(2), PIP5K1B(4), PPP1R12B(3), ROCK1(2), SRC(1), TLN1(5), VCL(2)	2052564	64	23	62	31	51	3	3	5	2	0	0.168	1.000	1.000
402	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K7(2), MAPK1(2), MAPK10(5), MAPK13(1), MAPK14(3), MAPK3(1), MAPK8IP2(3), MAPK8IP3(3), MAPK9(1), NFKB1(4), NFKBIA(1), NFKBIB(1), NFKBIL2(1), PIK3CA(3), PIK3CD(2), SYT1(4), TRAF3(3), TRAF5(2), TRAF6(2)	1532256	44	23	44	19	32	3	2	4	3	0	0.144	1.000	1.000
403	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	DAG1(2), ETFA(2), GCA(1), ITGA9(3), ITPKB(2), ITPR1(8), ITPR2(4), ITPR3(1), MAPK1(2), MAPK3(1), NR1I3(2), PDE3A(7), PDE3B(1), PI3(1), PIK3C2G(13), PIK3CA(3), PIK3CD(2), RIPK3(2), VASP(2)	2216989	59	23	58	28	41	4	3	5	6	0	0.226	1.000	1.000
404	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	41	CREB3(1), CREB5(2), CREBBP(4), DAG1(2), EGR3(1), EGR4(1), ELK1(1), FRS2(2), GNAQ(1), MAP1B(7), MAP2K7(2), MAPK1(2), MAPK10(5), MAPK3(1), MAPK8IP2(3), MAPK8IP3(3), MAPK9(1), NTRK1(2), OPN1LW(1), PIK3C2G(13), PIK3CA(3), PIK3CD(2), PTPN11(5), SHC1(1), SRC(1), TH(3)	2264793	70	23	68	36	49	8	1	5	7	0	0.434	1.000	1.000
405	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(4), DLG4(3), EPHB2(8), F2(3), F2RL1(2), F2RL2(3), F2RL3(1), MAP2K5(1), MAPK1(2), MAPK7(2), MYEF2(1), PLD1(3), PLD2(2), PTK2(2), RAF1(3), RASAL1(4), SRC(1), TEC(2), VAV1(2)	1250730	49	23	48	34	32	6	2	4	5	0	0.774	1.000	1.000
406	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BLNK(4), BTK(4), CALM1(1), ELK1(1), HRAS(2), LYN(2), MAPK14(3), MAPK3(1), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), PLCG1(1), PRKCA(5), RAF1(3), SHC1(1), SOS1(3), SYK(4), SYT1(4), VAV1(2)	1726238	55	22	55	26	38	6	3	4	4	0	0.347	1.000	1.000
407	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(6), ITGAV(3), ITGB3(2), MAPK1(2), MAPK3(1), PDGFRA(9), PIK3CA(3), PLCB1(18), PRKCA(5), PTK2(2), SMPD2(1), SRC(1)	1238211	53	22	52	29	39	5	0	5	4	0	0.492	1.000	1.000
408	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(3), CSF1R(3), DDX20(1), E2F1(2), E2F4(1), ETS1(2), ETS2(2), ETV3(4), HDAC5(4), HRAS(2), NCOR2(9), RBL1(2), RBL2(1), SIN3A(2), SIN3B(3)	1188773	41	22	41	20	30	3	1	5	2	0	0.277	1.000	1.000
409	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(4), CALM1(1), ELK1(1), FCER1A(2), HRAS(2), LYN(2), MAP2K7(2), MAPK1(2), MAPK3(1), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), PAK2(2), PIK3CA(3), PLA2G4A(1), PLCG1(1), RAF1(3), SHC1(1), SOS1(3), SYK(4), SYT1(4), VAV1(2)	1961835	55	22	55	32	37	6	3	4	5	0	0.732	1.000	1.000
410	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	APC(5), AXIN1(4), CCND1(1), CTNNB1(3), FZD1(1), GJA1(4), GSK3B(1), LBP(1), LEF1(1), MYD88(2), NFKB1(4), PDPK1(2), PIK3CA(3), RELA(1), TLR4(8)	1388726	41	22	39	27	25	5	4	4	3	0	0.875	1.000	1.000
411	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(5), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH3B1(1), ALDH3B2(2), AOC3(4), ASPA(1), CNDP1(2), DDC(5), HAL(3), HDC(5), MAOB(6), PRPS2(1)	1108359	47	22	46	31	27	6	4	5	5	0	0.640	1.000	1.000
412	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXT2(1), EXTL3(3), HS2ST1(1), HS3ST1(4), HS3ST2(1), HS3ST3A1(2), HS3ST5(3), HS6ST1(1), HS6ST2(1), HS6ST3(2), NDST1(1), NDST2(1), NDST3(7), NDST4(12)	925340	41	22	41	29	27	4	1	6	3	0	0.839	1.000	1.000
413	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD9(1), ADH1A(4), ADH1B(11), ADH1C(6), ADH4(7), ADH5(1), ADH6(2), ADH7(1), ADHFE1(2), DHRS1(2), DHRS2(1), DHRSX(2), ESCO2(2), MYST3(1), MYST4(1), NAT6(1), SH3GLB1(1)	1140400	46	22	45	25	33	4	2	5	2	0	0.702	1.000	1.000
414	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(4), ABCC2(3), ABCG2(4), BCHE(1), CES1(1), CES2(1), CYP3A4(3), CYP3A5(2), UGT1A1(1), UGT1A10(7), UGT1A3(3), UGT1A4(3), UGT1A5(4), UGT1A6(2), UGT1A7(5), UGT1A8(2), UGT1A9(5)	1044595	51	22	50	28	31	7	2	6	5	0	0.374	1.000	1.000
415	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(5), ALDH1A3(1), ALDH3A1(2), ALDH3B1(1), ALDH3B2(2), AOC3(4), DDC(5), EPX(4), GOT2(1), LPO(4), MAOB(6), MPO(2), PRDX2(1), PRDX6(1), TAT(2), TPO(11)	1001028	52	22	52	29	33	7	4	5	3	0	0.256	1.000	1.000
416	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(2), ESR2(2), PDE1A(10), PDE1B(1), PLCB1(18), PLCB2(2), VIP(1)	502907	36	22	32	20	34	0	0	1	1	0	0.336	1.000	1.000
417	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), DAG1(2), ITPKB(2), ITPR1(8), ITPR2(4), ITPR3(1), NFAT5(2), PDE6A(4), PDE6B(2), PDE6C(10), SLC6A13(4), TF(2)	1630647	47	22	47	28	35	1	2	5	4	0	0.447	1.000	1.000
418	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CHUK(1), ELK1(1), MAP2K3(2), MAP3K14(2), MAP3K7(1), MAPK14(3), MYD88(2), NFKB1(4), NFKBIA(1), PPARA(1), RELA(1), TLR10(3), TLR2(4), TLR3(3), TLR4(8), TLR7(4), TLR9(3), TRAF6(2)	1653641	46	22	46	24	31	3	3	4	5	0	0.489	1.000	1.000
419	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(1), CHAT(7), COMT(2), DBH(3), DDC(5), GAD1(4), GAD2(1), HDC(5), PAH(2), PNMT(2), SLC18A3(1), TH(3), TPH1(1)	649721	38	21	37	25	30	4	2	0	2	0	0.446	1.000	1.000
420	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(4), BTG1(1), CLOCK(1), CRY1(1), CRY2(2), ETV6(1), GFRA1(4), GSTM3(2), HERPUD1(1), HSPA8(1), KLF9(1), MYF6(5), NCKAP1(1), NCOA4(1), NR1D2(1), PER1(3), PIGF(1), PPP1R3C(1), PPP2CB(1), PSMA4(1), PURA(1), SF3A3(2), TOB1(2), UCP3(1), UGP2(1), VAPA(1), ZFR(4)	1665283	46	21	46	15	22	5	5	8	6	0	0.219	1.000	1.000
421	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(2), AKT2(1), AKT3(2), DAG1(2), GNAQ(1), ITPKB(2), ITPR1(8), ITPR2(4), ITPR3(1), NFKB1(4), NFKBIA(1), NFKBIB(1), NFKBIL2(1), PDK1(1), PHKA2(2), PIK3CB(2), PLD1(3), PLD2(2)	2046775	40	21	40	29	25	4	4	3	4	0	0.787	1.000	1.000
422	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(5), CREB3(1), CREB5(2), DAG1(2), EPHB2(8), GNAQ(1), ITPKB(2), MAP2K7(2), MAPK1(2), MAPK10(5), MAPK8IP2(3), MAPK8IP3(3), MAPK9(1)	1303484	37	21	36	23	25	3	1	3	5	0	0.737	1.000	1.000
423	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	15	ACTN1(1), ACTN2(6), ACTN3(3), CAPN1(1), ITGA1(11), ITGB1(2), ITGB3(2), PTK2(2), SPTAN1(2), SRC(1), TLN1(5)	1265426	36	21	35	18	26	3	1	3	2	1	0.194	1.000	1.000
424	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF2B1(2), EIF2B3(1), EIF2B4(1), FLT1(6), FLT4(8), HRAS(2), KDR(8), NOS3(2), PIK3CA(3), PLCG1(1), PRKCA(5), PTK2(2), SHC1(1), VHL(2)	1559029	44	21	44	28	28	6	0	5	5	0	0.809	1.000	1.000
425	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(3), AGT(2), AGTR2(1), EDN1(2), EDNRA(3), EGF(4), EGFR(6), HRAS(2), MYC(2), NFKB1(4), PLCG1(1), PRKCA(5), RELA(1)	936261	36	20	36	23	28	3	2	2	1	0	0.631	1.000	1.000
426	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDT1(1), DIAPH2(1), MCM2(4), MCM3(6), MCM5(1), MCM6(2), ORC1L(4), ORC5L(1), POLA2(2), POLD1(1), POLD2(1), POLD3(1), POLE(6), POLE2(1), RFC2(1), RPA4(1), UBC(2)	2309024	36	20	36	25	22	2	2	6	4	0	0.881	1.000	1.000
427	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	CABIN1(4), CALM1(1), CAMK1G(2), HDAC5(4), IGF1R(1), INSR(3), MAPK14(3), MAPK7(2), MEF2A(2), MEF2C(1), MEF2D(1), NFATC1(5), NFATC2(1), PIK3CA(3), SYT1(4)	1594067	37	20	37	33	25	6	1	3	2	0	0.970	1.000	1.000
428	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(5), ADC(2), AGMAT(1), ALDH18A1(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), AOC3(4), ARG2(1), ASL(1), ASS1(1), CPS1(8), GATM(1), MAOB(6), SMS(1)	1332430	45	20	45	24	23	6	3	6	7	0	0.385	1.000	1.000
429	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(3), ACAA1(2), ACAA2(1), ACADM(1), ACADS(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), AOX1(5), AUH(1), BCAT1(5), DLD(1), EHHADH(1), HADHA(1), HADHB(2), HIBCH(1), HMGCL(3), HMGCS2(7), HSD17B4(1), IVD(2), MCCC1(1), MCCC2(1), MUT(1), OXCT1(1)	1975191	53	20	52	27	32	6	0	8	7	0	0.582	1.000	1.000
430	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(4), FBP1(1), GOT2(1), GPT(1), GPT2(1), MDH2(2), ME1(4), ME3(2), PGK1(1), PGK2(4), PKLR(4), PKM2(1), TKT(1), TKTL2(4)	925358	32	20	31	26	24	2	2	4	0	0	0.809	1.000	1.000
431	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(1), GTF2A1L(1), GTF2E1(1), GTF2E2(2), GTF2F1(1), GTF2F2(1), GTF2H1(1), GTF2I(1), GTF2IRD1(3), TAF1(3), TAF1L(14), TAF2(1), TAF4(5), TAF5L(2), TAF6L(1), TAF7L(3), TAF9(1), TBPL1(1), TBPL2(1)	1652831	44	20	44	25	34	2	1	5	2	0	0.769	1.000	1.000
432	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(1), IFNA1(1), IFNB1(1), IL1A(3), IL1B(1), IL1R1(3), IL1RAP(2), IL1RN(1), IRAK2(4), IRAK3(1), MAP2K3(2), MAP3K14(2), MAP3K7(1), MAPK14(3), MYD88(2), NFKB1(4), NFKBIA(1), RELA(1), TRAF6(2)	1346889	36	20	36	21	24	1	2	5	4	0	0.654	1.000	1.000
433	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	CBL(2), CFLAR(1), E2F1(2), HRAS(2), IL2RB(3), JAK1(1), MAPK1(2), MAPK3(1), MYC(2), PIK3CA(3), PPIA(1), RAF1(3), RPS6KB1(1), SHC1(1), SOS1(3), STAT5A(1), STAT5B(1), SYK(4)	1648215	34	20	34	23	20	4	2	3	5	0	0.848	1.000	1.000
434	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(6), CAP1(1), CDC25C(1), GNAS(4), HRAS(2), MAPK1(2), MAPK3(1), MYT1(4), PIN1(1), PRKACB(1), PRKAR2B(3), RPS6KA1(3), SRC(1)	936592	30	20	30	24	17	5	1	4	3	0	0.898	1.000	1.000
435	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(4), EP300(7), IL1B(1), MAP2K3(2), MAP3K14(2), MAP3K7(1), MAPK14(3), MYD88(2), NFKB1(4), NFKBIA(1), NR3C1(3), RELA(1), TGFBR2(2), TLR2(4)	1358372	38	20	38	18	26	2	2	6	2	0	0.543	1.000	1.000
436	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(8), ATP5O(1), ATP6AP1(1), ATP6V0A1(4), ATP6V0A4(7), ATP6V1B2(2), ATP6V1C2(4), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(2), ATP7A(1), ATP7B(3), COX10(1), NDUFA10(2), NDUFB5(2), NDUFS2(1), SDHA(1), UQCRC1(1), UQCRFS1(1)	1752291	47	20	47	20	33	1	1	5	7	0	0.219	1.000	1.000
437	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(5), AXIN1(4), CREBBP(4), CTNNB1(3), EP300(7), FZD1(1), GSK3B(1), LEF1(1), TRRAP(9)	1519255	35	20	35	17	22	2	3	4	4	0	0.604	1.000	1.000
438	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	ARFIP2(1), CHN1(2), LIMK1(1), MYL2(2), MYLK(11), NCF2(2), PDGFRA(9), PIK3CA(3), PLD1(3), PPP1R12B(3), RPS6KB1(1), TRIO(4), VAV1(2)	1579904	44	20	43	36	32	2	3	4	3	0	0.976	1.000	1.000
439	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	EGFR(6), IGF1R(1), MYC(2), POLR2A(1), PRKCA(5), RB1(2), TEP1(15), TERF1(1), TERT(1), TNKS(2)	1246389	36	20	36	24	24	4	3	2	2	1	0.746	1.000	1.000
440	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CHUK(1), EGR3(1), GNAQ(1), MYC(2), NFATC1(5), NFATC2(1), NFKB1(4), NFKBIA(1), PLCG1(1), PRKACB(1), PRKAR2B(3), RELA(1), SYT1(4), VIP(1), VIPR2(3)	1274274	31	20	31	23	23	3	2	2	1	0	0.868	1.000	1.000
441	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(2), AGTR1(2), ATF2(1), CALM1(1), EGFR(6), ELK1(1), GNAQ(1), HRAS(2), MAPK1(2), MAPK3(1), MEF2A(2), MEF2C(1), MEF2D(1), PRKCA(5), PTK2(2), PTK2B(2), RAF1(3), SHC1(1), SOS1(3), SRC(1), SYT1(4)	1506576	44	19	44	23	30	8	1	3	2	0	0.490	1.000	1.000
442	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ABAT(3), ACADS(2), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH5A1(3), EHHADH(1), GAD1(4), GAD2(1), HADHA(1), HMGCL(3), L2HGDH(2), OXCT1(1), PDHA2(6), SDS(1)	1185870	40	19	40	19	27	4	1	6	2	0	0.317	1.000	1.000
443	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD1(1), DRD2(2), GRM1(7), PLCB1(18), PPP1R1B(1), PRKACB(1), PRKAR2B(3)	728005	33	19	32	26	28	1	2	1	1	0	0.799	1.000	1.000
444	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(6), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), GNAS(4), HRAS(2), MAPK1(2), MAPK14(3), MAPK3(1), PIK3CA(3), PRKACB(1), PRKAR2B(3), PRKCA(5), RPS6KA1(3), RPS6KA5(1), SOS1(3)	1305620	43	19	43	26	30	7	1	4	1	0	0.696	1.000	1.000
445	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), BIRC3(1), CASP10(1), CASP7(2), CASP8(1), CASP9(2), CFLAR(1), CHUK(1), DFFB(1), GAS2(1), LMNA(1), MAP3K14(2), NFKB1(4), NFKBIA(1), RELA(1), SPTAN1(2), TNFRSF10A(2), TNFSF10(1), TNFSF12(1)	1526010	27	19	27	24	19	2	1	2	3	0	0.964	1.000	1.000
446	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), EGF(4), EGFR(6), ELK1(1), HRAS(2), JAK1(1), MAPK3(1), PIK3CA(3), PLCG1(1), PRKCA(5), RAF1(3), SHC1(1), SOS1(3), STAT1(3), STAT3(1), STAT5A(1)	1711091	37	19	37	27	23	7	1	5	1	0	0.951	1.000	1.000
447	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(5), EPHB1(8), FYN(1), ITGA1(11), ITGB1(2), L1CAM(3), LYN(2), RAP1B(1), SELP(10)	720453	43	19	42	20	36	0	1	4	2	0	0.274	1.000	1.000
448	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ANXA1(1), CALM1(1), GNAS(4), NFKB1(4), NOS3(2), NR3C1(3), PIK3CA(3), RELA(1), SYT1(4)	814508	23	19	23	18	17	3	0	3	0	0	0.943	1.000	1.000
449	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(1), GHR(7), HRAS(2), INSR(3), JAK2(1), MAPK1(2), MAPK3(1), PIK3CA(3), PLCG1(1), PRKCA(5), RAF1(3), RPS6KA1(3), SHC1(1), SLC2A4(4), SOS1(3), STAT5A(1), STAT5B(1)	1515037	42	19	42	24	29	6	1	4	2	0	0.545	1.000	1.000
450	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(3), ALDH4A1(1), ALDH5A1(3), CAD(5), CPS1(8), EPRS(3), GAD1(4), GAD2(1), GCLC(1), GCLM(2), GFPT1(1), GMPS(1), GOT2(1), GPT(1), GPT2(1), GSS(2), NADSYN1(2)	1515931	40	19	40	24	26	2	1	8	3	0	0.668	1.000	1.000
451	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(6), CALM1(1), ELK1(1), GNAQ(1), GNAS(4), HRAS(2), MAPK3(1), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), PLCG1(1), PRKACB(1), PRKAR2B(3), PRKCA(5), RAF1(3), SYT1(4)	1585661	47	19	47	33	28	9	3	5	2	0	0.884	1.000	1.000
452	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B10(2), ALDOA(1), ALDOB(4), FBP1(1), GMDS(1), GMPPB(1), HK2(5), HK3(3), MTMR1(1), MTMR6(1), PFKFB1(2), PFKFB2(1), PFKL(2), PGM2(2), PMM2(1), RDH11(1), RDH12(1), RDH13(1)	1689049	31	19	30	21	25	1	2	1	2	0	0.539	1.000	1.000
453	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(3), ADC(2), ALDH4A1(1), ALDH5A1(3), CAD(5), CPS1(8), EPRS(3), GAD1(4), GAD2(1), GCLC(1), GCLM(2), GFPT1(1), GLUD2(2), GMPS(1), GOT2(1), GPT(1), GPT2(1), GSS(2), NADSYN1(2)	1803415	44	19	44	27	26	3	2	8	5	0	0.675	1.000	1.000
454	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(1), ABAT(3), ADSSL1(1), AGXT(1), AGXT2(3), ASL(1), ASNS(3), ASPA(1), ASS1(1), CAD(5), CRAT(2), DARS(2), DDO(4), DLAT(1), DLD(1), GAD1(4), GAD2(1), GOT2(1), GPT(1), GPT2(1), NARS(1), PC(1), PDHA2(6)	1729044	47	19	46	32	36	5	1	3	2	0	0.693	1.000	1.000
455	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(1), GLB1(2), HEXA(2), HEXB(2), LCT(13), SLC33A1(1), ST3GAL1(2), ST6GALNAC3(2), ST6GALNAC5(2), ST6GALNAC6(1), ST8SIA1(1), ST8SIA5(5)	752489	34	19	34	20	23	3	1	6	1	0	0.560	1.000	1.000
456	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ACTG2(1), ADCY3(1), ADCY9(1), ARF4(1), ATP6V0A1(4), ATP6V0A2(1), ATP6V0A4(7), ATP6V0D2(1), ATP6V1C2(4), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(2), ERO1L(1), GNAS(4), PDIA4(2), PLCG1(1), PLCG2(11), PRKCA(5)	1694159	56	19	56	36	40	4	1	4	7	0	0.524	1.000	1.000
457	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), ELK1(1), HRAS(2), JAK1(1), MAPK3(1), PDGFRA(9), PIK3CA(3), PLCG1(1), PRKCA(5), RAF1(3), SHC1(1), SOS1(3), STAT1(3), STAT3(1), STAT5A(1)	1593836	36	19	36	20	19	7	0	7	3	0	0.744	1.000	1.000
458	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	27	BCAR1(2), CALM1(1), GNAQ(1), HRAS(2), MAP2K3(2), MAPK1(2), MAPK14(3), MAPK3(1), PLCG1(1), PRKCA(5), PTK2B(2), RAF1(3), SHC1(1), SOS1(3), SRC(1), SYT1(4)	1281127	34	19	34	13	24	6	0	3	1	0	0.129	1.000	1.000
459	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT2(1), AKT3(2), GSK3B(1), IL4R(3), IRS2(1), JAK1(1), MAP4K1(4), MAPK1(2), MAPK3(1), PDK1(1), PIK3CA(3), PIK3CD(2), PPP1R13B(2), RAF1(3), SHC1(1), SOS1(3), SOS2(5), STAT6(4)	1670515	40	19	40	20	27	7	1	2	3	0	0.392	1.000	1.000
460	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(2), EGF(4), EGFR(6), HRAS(2), MAPK1(2), MAPK3(1), PTPRB(16), RAF1(3), SHC1(1), SOS1(3), SPRY1(1), SPRY3(3), SRC(1)	1139866	45	19	45	28	30	6	2	4	3	0	0.842	1.000	1.000
461	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	CREB3(1), CREB5(2), DUSP9(2), EEF2K(4), MAPK1(2), MAPK3(1), MKNK1(1), NFKB1(4), RAP1A(1), RPS6KA1(3), SHC1(1), SOS1(3), SOS2(5), TRAF3(3)	1277603	33	19	33	14	23	4	1	1	4	0	0.223	1.000	1.000
462	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CALM1(1), CD3D(2), ELK1(1), FYN(1), HRAS(2), LCK(3), MAPK3(1), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), NFKB1(4), NFKBIA(1), PIK3CA(3), PLCG1(1), PRKCA(5), RAF1(3), RELA(1), SHC1(1), SOS1(3), SYT1(4), VAV1(2), ZAP70(2)	2160218	55	19	55	29	38	8	2	3	4	0	0.539	1.000	1.000
463	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(5), AXIN1(4), BTRC(3), CCND1(1), CREBBP(4), CSNK2A1(1), CTNNB1(3), FZD1(1), GSK3B(1), MAP3K7(1), MYC(2), NLK(2), PPARD(1), WIF1(4)	1334569	33	19	33	19	19	2	3	3	6	0	0.814	1.000	1.000
464	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(3), DARS(2), EPRS(3), FARS2(2), GARS(2), IARS(5), KARS(2), LARS(1), MARS2(2), NARS(1), RARS(4), SARS(1), WARS(3), WARS2(1), YARS(1)	1469564	34	18	33	14	25	2	2	2	3	0	0.261	1.000	1.000
465	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(6), CD3D(2), CD4(1), CREBBP(4), GNAS(4), HLA-DRA(3), HLA-DRB1(2), LCK(3), PRKACB(1), PRKAR2B(3), PTPRC(4), ZAP70(2)	1034141	35	18	35	28	25	5	1	3	1	0	0.936	1.000	1.000
466	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(6), GNAS(4), PRKAA1(1), PRKAA2(4), PRKAB1(1), PRKACB(1), PRKAG1(1), PRKAG2(4), PRKAR2B(3)	698101	25	18	24	19	15	4	1	2	3	0	0.919	1.000	1.000
467	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(6), CD3D(2), CD4(1), CREBBP(4), GNAS(4), HLA-DRA(3), HLA-DRB1(2), LCK(3), PRKACB(1), PRKAR2B(3), PTPRC(4), ZAP70(2)	1034141	35	18	35	28	25	5	1	3	1	0	0.936	1.000	1.000
468	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(1), CASP7(2), CASP8(1), CFLAR(1), DAXX(5), DFFB(1), LMNA(1), MAP3K7(1), PAK2(2), PRKDC(6), PTPN13(3), RB1(2), RIPK2(1), SPTAN1(2)	1865330	30	18	30	19	20	3	0	4	2	1	0.823	1.000	1.000
469	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(1), ATM(2), ATR(8), CCNA1(2), CCND1(1), CCNE1(1), CDC25A(3), CDK4(2), CDK6(1), CDKN1A(1), CDKN1B(1), E2F1(2), GSK3B(1), RB1(2), TFDP1(1)	1312376	29	18	29	11	16	2	3	4	3	1	0.278	1.000	1.000
470	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	BCR(5), HRAS(2), JAK2(1), MAPK3(1), MYC(2), PIK3CA(3), RAF1(3), SOS1(3), STAT1(3), STAT5A(1), STAT5B(1)	1282401	25	18	25	16	14	5	1	5	0	0	0.836	1.000	1.000
471	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CARM1(2), CBS(2), GGT1(1), MARS2(2), MAT1A(1), METTL2B(2), PAPSS2(2), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(3), SEPHS1(2), SEPHS2(1)	1146816	25	18	25	14	16	3	2	3	1	0	0.528	1.000	1.000
472	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), CYP2C19(7), CYP2C9(12), DHRS1(2), DHRS2(1), DHRSX(2), EHHADH(1), ESCO2(2), HADHA(1), MYST3(1), MYST4(1), NAT6(1), SH3GLB1(1)	1414666	44	18	42	31	29	4	2	5	4	0	0.895	1.000	1.000
473	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA2(2), POLD1(1), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLG2(2), POLH(1), POLK(4), POLL(4), POLM(1), POLQ(9), PRIM2(3), REV1(1), REV3L(2)	1849007	39	18	39	16	18	0	5	11	5	0	0.437	1.000	1.000
474	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(2), AASDH(3), AASS(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), BBOX1(1), DOT1L(4), EHHADH(1), EHMT1(2), GCDH(1), HADHA(1), PLOD1(1), PLOD2(4), PLOD3(2), SDS(1)	1682527	36	18	36	16	21	5	0	6	4	0	0.270	1.000	1.000
475	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(3), CCR2(6), CCR3(3), CCR4(2), CCR5(4), CD28(1), CD4(1), CXCR3(1), CXCR4(1), IFNGR1(2), IFNGR2(1), IL12B(1), IL12RB1(6), IL18R1(6), IL2(1), IL4(1), IL4R(3)	911023	43	18	42	29	32	2	1	4	4	0	0.554	1.000	1.000
476	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT2(1), GALNT3(1), GALNT4(2), GALNT6(4), GALNT7(2), GALNT8(5), GALNT9(1), GCNT1(2), ST3GAL1(2), WBSCR17(11)	661263	32	18	32	20	24	3	1	3	1	0	0.682	1.000	1.000
477	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CAMK1G(2), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CAMK4(3), ESRRA(1), HDAC5(4), MEF2A(2), MEF2C(1), MEF2D(1), PPARA(1), SLC2A4(4), SYT1(4)	919768	30	18	30	19	25	1	0	2	2	0	0.551	1.000	1.000
478	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(6), GNAS(4), PLCE1(15), PRKACB(1), PRKAR2B(3)	667959	29	18	28	25	19	5	2	2	1	0	0.954	1.000	1.000
479	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	GTF2A1(1), GTF2E1(1), GTF2F1(1), HDAC3(3), NCOA1(1), NCOA2(5), NCOA3(5), NCOR2(9), POLR2A(1), RARA(1), RXRA(2), TBP(2)	1134885	32	18	32	13	25	0	1	1	5	0	0.211	1.000	1.000
480	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), GNAQ(1), HTR2C(3), PLCB1(18), TUB(2)	326262	26	18	25	15	21	1	0	1	3	0	0.448	1.000	1.000
481	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(2), ACAA2(1), ACADL(3), ACADM(1), ACADS(2), ACADSB(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), AOX1(5), BCAT1(5), EHHADH(1), HADHA(1), HADHB(2), HMGCL(3), IVD(2), MCCC1(1), MCCC2(1), MUT(1), OXCT1(1), SDS(1)	1652460	46	18	46	25	31	4	0	5	6	0	0.643	1.000	1.000
482	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(11), AGT(2), AGTR1(2), AGTR2(1), BDKRB2(3), KNG1(4), NOS3(2), REN(1)	454627	26	17	26	19	15	3	1	4	3	0	0.705	1.000	1.000
483	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(3), ARFGAP3(1), ARFGEF2(9), CLTA(1), CLTB(1), COPA(2), GBF1(4), GPLD1(4)	747784	25	17	25	13	13	1	2	6	3	0	0.704	1.000	1.000
484	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(6), BAX(2), CSF2RB(3), IGF1R(1), KIT(3), KITLG(1), PIK3CA(3), PRKACB(1), PRKAR2B(3)	1001654	23	17	23	28	13	6	2	1	1	0	0.997	1.000	1.000
485	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(4), FBP1(1), GOT2(1), GPT(1), GPT2(1), MDH2(2), ME1(4), ME3(2), PGK1(1), PKLR(4), PKM2(1), TKT(1)	827182	24	17	23	14	17	1	2	4	0	0	0.492	1.000	1.000
486	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	APAF1(1), ATM(2), BAX(2), CASP7(2), CASP9(2), PRKCA(5), PTK2(2), STAT1(3), TLN1(5)	1207317	24	17	24	15	12	6	2	4	0	0	0.832	1.000	1.000
487	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(13), NRG2(1), NRG3(6), PRKCA(5)	408170	25	17	24	12	21	3	0	0	1	0	0.379	1.000	1.000
488	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(5), CYP2A6(3), CYP2A7(2), NAT1(1), NAT2(1), XDH(13)	365991	27	17	27	19	19	2	4	0	2	0	0.485	1.000	1.000
489	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(5), IARS(5), IARS2(4), ILVBL(2), LARS(1), PDHA2(6), VARS(5)	862897	28	17	27	14	23	0	1	2	2	0	0.487	1.000	1.000
490	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(3), ACACA(6), ACACB(5), ACADM(1), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), ALDH7A1(1), EHHADH(1), HADHA(1), HIBCH(1), LDHAL6B(1), LDHC(3), MUT(1)	1818954	33	17	33	18	18	5	3	5	2	0	0.586	1.000	1.000
491	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), ABP1(5), AOC3(4), CES1(1), CES7(4), ESCO2(2), LIPA(1), MYST3(1), MYST4(1), NAT6(1), PLA1A(3), PRDX6(1), SH3GLB1(1)	1158210	26	17	26	25	19	2	1	2	2	0	0.992	1.000	1.000
492	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(4), CALM1(1), CAPN2(1), EP300(7), MEF2D(1), NFATC1(5), NFATC2(1), PRKCA(5), SYT1(4)	1120865	29	17	29	12	20	3	2	3	1	0	0.297	1.000	1.000
493	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	EIF4A2(2), EIF4B(2), EIF4G1(7), EIF4G3(6), FKBP1A(1), MKNK1(1), PDPK1(2), PIK3CA(3), PTEN(1), RPS6KB1(1), TSC1(1), TSC2(3)	1267790	30	17	29	15	16	5	2	2	5	0	0.629	1.000	1.000
494	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(1), IL1A(3), IL1R1(3), MAP3K14(2), MAP3K7(1), MYD88(2), NFKB1(4), NFKBIA(1), RELA(1), TLR4(8), TNFRSF1A(1), TNFRSF1B(2), TRAF6(2)	1096044	31	17	31	17	20	0	3	4	4	0	0.598	1.000	1.000
495	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(3), PLCB1(18), PLCG1(1), PRKCA(5), VAV1(2)	588685	29	17	28	20	26	2	0	0	1	0	0.779	1.000	1.000
496	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT2(1), AKT3(2), MAPK1(2), MAPK3(1), PDK1(1), PIK3CA(3), PIK3CD(2), PTEN(1), PTK2B(2), RBL2(1), SHC1(1), SOS1(3)	939678	20	17	20	11	13	4	0	1	2	0	0.594	1.000	1.000
497	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(8), HLA-DRA(3), HLA-DRB1(2), IFNGR1(2), IFNGR2(1), IL12B(1), IL12RB1(6), IL18(2), IL18R1(6), IL2(1), IL4(1), IL4R(3)	577742	37	17	37	18	31	2	0	1	3	0	0.374	1.000	1.000
498	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	CASP9(2), CHUK(1), GH1(1), GHR(7), NFKB1(4), NFKBIA(1), PDPK1(2), PIK3CA(3), RELA(1)	640303	22	16	21	14	18	2	1	0	1	0	0.775	1.000	1.000
499	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ABAT(3), AGXT(1), AGXT2(3), ASL(1), ASNS(3), ASPA(1), CAD(5), CRAT(2), DARS(2), DDO(4), GAD1(4), GAD2(1), GOT2(1), GPT(1), GPT2(1), NARS(1), PC(1)	1193670	36	16	35	28	26	5	1	3	1	0	0.802	1.000	1.000
500	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(2), ATR(8), BRCA1(4), BRCA2(3), FANCA(3), FANCE(1), FANCF(1), FANCG(2), MRE11A(1), RAD17(2), RAD50(1)	1977039	28	16	28	18	18	0	2	3	5	0	0.926	1.000	1.000
501	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(2), CREBBP(4), EP300(7), NCOA3(5), PRKACB(1), PRKAR2B(3), RARA(1), RXRA(2)	945934	25	16	25	11	16	1	2	2	4	0	0.482	1.000	1.000
502	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(4), EGFR(6), MAPK14(3), NCOR2(9), RARA(1), RXRA(2), THRB(4)	783964	29	16	29	18	24	0	1	3	1	0	0.693	1.000	1.000
503	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(2), CHIA(3), CHIT1(1), CTBS(1), GFPT1(1), GNE(1), HEXA(2), HEXB(2), HK2(5), HK3(3), MTMR1(1), MTMR6(1), NANS(1), PGM3(1)	1311080	25	16	25	11	19	1	0	5	0	0	0.338	1.000	1.000
504	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(1), BAIAP2(2), CASP1(1), CASP7(2), CASP8(1), GAPDH(1), INSR(3), ITCH(2), MAGI1(7), MAGI2(5), RERE(2), WWP1(1), WWP2(3)	1099037	31	16	31	26	25	2	0	2	2	0	0.968	1.000	1.000
505	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), ELK1(1), HRAS(2), IL2(1), IL2RB(3), JAK1(1), LCK(3), MAPK3(1), RAF1(3), SHC1(1), SOS1(3), STAT5A(1), STAT5B(1), SYK(4)	1054767	26	16	26	15	16	5	1	2	2	0	0.569	1.000	1.000
506	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	19	HLA-A(2), IL18(2), ITGB1(2), KLRC3(3), KLRC4(2), KLRD1(1), MAPK3(1), PIK3CA(3), PTK2B(2), SYK(4), VAV1(2)	827263	24	16	24	17	19	2	0	1	2	0	0.845	1.000	1.000
507	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(3), ACACA(6), ACADL(3), ACADM(1), ACADSB(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(2), EHHADH(1), HADHA(1), LDHC(3), MUT(1), SDS(1)	1518446	33	16	33	16	23	3	1	4	2	0	0.470	1.000	1.000
508	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	GLI2(9), GLI3(3), GSK3B(1), PRKACB(1), PRKAR2B(3), SHH(1), SMO(3), SUFU(1)	758888	22	16	22	17	14	5	2	1	0	0	0.811	1.000	1.000
509	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(1), IFNB1(1), JAK1(1), PTPRU(7), REG1A(2), STAT1(3), TYK2(3)	572063	18	16	18	10	11	0	0	5	2	0	0.632	1.000	1.000
510	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(1), HRAS(2), JAK2(1), MAPK3(1), MPL(3), PIK3CA(3), PLCG1(1), PRKCA(5), RAF1(3), SHC1(1), SOS1(3), STAT1(3), STAT3(1), STAT5A(1), STAT5B(1), THPO(2)	1367604	32	16	32	16	20	6	1	5	0	0	0.585	1.000	1.000
511	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(1), IL2(1), IL4(1), MAP3K5(7), MAPK14(3), NFKB1(4), NFKBIA(1), RELA(1), TNFRSF9(2)	877868	22	15	21	10	16	0	0	4	2	0	0.491	1.000	1.000
512	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CDKN1A(1), GNAQ(1), NFATC1(5), NFATC2(1), NFATC3(2), NFATC4(6), PLCG1(1), PRKCA(5), SP1(2), SYT1(4)	956308	29	15	29	13	20	4	2	1	2	0	0.349	1.000	1.000
513	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(6), CFTR(14), GNAS(4), PRKACB(1), PRKAR2B(3)	593364	28	15	27	27	17	4	2	3	2	0	0.976	1.000	1.000
514	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(4), FBP1(1), G6PD(1), PFKL(2), PGD(2), PGM1(1), PGM3(1), PRPS1L1(4), PRPS2(1), RBKS(1), TALDO1(1), TKT(1), TKTL2(4)	1107620	25	15	24	22	20	0	0	3	2	0	0.800	1.000	1.000
515	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), BHMT(1), CBS(2), DNMT1(6), DNMT3A(2), DNMT3B(3), MARS2(2), MAT1A(1), MTAP(1), MTR(2), TAT(2)	956517	23	15	23	12	13	2	4	2	2	0	0.541	1.000	1.000
516	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(4), PGAP1(1), PIGC(2), PIGF(1), PIGG(2), PIGK(1), PIGL(1), PIGN(1), PIGO(3), PIGQ(2), PIGS(1), PIGU(1), PIGV(2), PIGX(1), PIGZ(1)	1093158	24	15	24	16	16	1	2	4	1	0	0.683	1.000	1.000
517	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT3(1), B3GNT4(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), FUT2(1), FUT3(2), FUT5(1), FUT6(1), FUT9(7), ST3GAL6(1), ST8SIA1(1)	725080	19	15	19	11	12	3	2	1	1	0	0.468	1.000	1.000
518	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(4), EP300(7), FYN(1), IL7(2), IL7R(6), JAK1(1), LCK(3), PIK3CA(3), PTK2B(2), STAT5A(1), STAT5B(1)	1275208	31	15	31	17	20	2	2	3	4	0	0.706	1.000	1.000
519	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(1), ELK1(1), HRAS(2), INSR(3), MAPK3(1), PIK3CA(3), PTPN11(5), RAF1(3), SHC1(1), SLC2A4(4), SOS1(3)	1170120	27	15	26	17	14	7	0	4	2	0	0.833	1.000	1.000
520	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	CASP9(2), CDC42(1), CHUK(1), ELK1(1), HRAS(2), MAPK3(1), NFKB1(4), PIK3CA(3), RAF1(3), RALGDS(4), RELA(1)	842164	23	15	23	13	16	4	1	2	0	0	0.598	1.000	1.000
521	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	JAK1(1), JAK2(1), PIAS3(3), PTPRU(7), REG1A(2), SRC(1), STAT3(1)	693082	16	15	16	14	10	1	0	2	3	0	0.884	1.000	1.000
522	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(3), APOA1(1), APOA4(2), APOC1(1), APOC2(1), APOE(1), CETP(1), CYP7A1(3), HMGCR(3), LDLR(2), LIPC(4), LPL(1), LRP1(13), SCARB1(1)	1260976	37	15	37	19	22	7	1	5	2	0	0.265	1.000	1.000
523	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(4), ARG2(1), ASL(1), CKMT2(1), CPS1(8), GAMT(2), GATM(1), OAT(2), PYCR1(1), SMS(1)	791856	22	15	22	11	15	2	0	3	2	0	0.423	1.000	1.000
524	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	LCT(13), PGM1(1), PYGL(3), PYGM(5)	602317	22	14	22	14	15	2	0	4	1	0	0.543	1.000	1.000
525	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(6), ACACB(5), FASN(5), MCAT(1), OLAH(3)	726412	20	14	20	12	12	3	2	1	2	0	0.553	1.000	1.000
526	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(3), B3GALNT1(1), FUT2(1), FUT9(7), HEXA(2), HEXB(2), NAGA(1), ST3GAL1(2), ST8SIA1(1)	490032	20	14	20	12	13	3	0	2	2	0	0.499	1.000	1.000
527	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG7(2), BECN1(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(1), IFNA21(2), IFNA4(1), IFNA5(1), IFNA8(1), PIK3C3(1), PIK3R4(1), PRKAA1(1), PRKAA2(4), ULK1(2), ULK2(2)	953527	23	14	22	16	14	3	1	3	2	0	0.812	1.000	1.000
528	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(1), ELK1(1), HRAS(2), IGF1R(1), MAPK3(1), PIK3CA(3), PTPN11(5), RAF1(3), SHC1(1), SOS1(3)	1132012	21	14	20	12	9	8	0	3	1	0	0.754	1.000	1.000
529	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(4), EP300(7), LPL(1), NCOA1(1), NCOA2(5), PPARG(2), RXRA(2)	847505	22	14	22	10	15	1	1	2	3	0	0.618	1.000	1.000
530	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(5), AXIN1(4), BTRC(3), CTNNB1(3), DLL1(1), FZD1(1), GSK3B(1), NOTCH1(1)	966675	19	14	19	10	8	3	2	2	4	0	0.655	1.000	1.000
531	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), BIRC3(1), CASP10(1), CASP7(2), CASP8(1), CASP9(2), DFFB(1), PRF1(2), SCAP(1), SREBF1(3), SREBF2(1)	832423	16	14	16	17	12	2	1	1	0	0	0.968	1.000	1.000
532	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT2(1), AKT3(2), CDKN1A(1), ELK1(1), HRAS(2), NGFR(5), NTRK1(2), PIK3CA(3), PIK3CD(2), SHC1(1), SOS1(3)	732975	23	14	23	11	13	8	0	2	0	0	0.339	1.000	1.000
533	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(1), JAK2(1), PIAS3(3), PTPRU(7), REG1A(2)	624071	14	14	14	10	9	0	0	2	3	0	0.791	1.000	1.000
534	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(5), CREBBP(4), EP300(7), MAP3K7(1), MAPK3(1), TGFBR2(2)	1175736	20	14	20	13	11	2	1	4	2	0	0.945	1.000	1.000
535	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	MUSK(9), PIK3CA(3), PTK2(2), PTK2B(2), SRC(1), TERT(1)	740296	18	13	18	17	13	2	1	1	1	0	0.906	1.000	1.000
536	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(9), MAP2(6), PRKACB(1), PRKAG1(1), PRKAR2B(3), PRKCE(2)	829590	22	13	22	13	14	3	1	2	2	0	0.812	1.000	1.000
537	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CAMK1G(2), CAMK2A(1), CAMK2B(1), CAMK2D(3), CAMK2G(1), CAMK4(3), CAMKK2(3), SYT1(4)	532987	19	13	19	14	17	1	0	0	1	0	0.619	1.000	1.000
538	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), ARHGDIB(1), BIRC3(1), CASP1(1), CASP10(1), CASP2(1), CASP7(2), CASP8(1), CASP9(2), DFFB(1), LMNA(1), PRF1(2)	893777	15	13	15	16	10	2	1	1	1	0	0.983	1.000	1.000
539	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CCL2(1), CCR5(4), CXCL12(1), CXCR4(1), GNAQ(1), MAPK14(3), PLCG1(1), PRKCA(5), PTK2B(2), SYT1(4)	631943	24	13	24	14	16	3	2	3	0	0	0.465	1.000	1.000
540	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), MAP3K14(2), NFKB1(4), NFKBIA(1), RELA(1), TRAF3(3), TRAF6(2)	826776	14	13	14	10	12	0	0	1	1	0	0.819	1.000	1.000
541	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	HRAS(2), MAPK1(2), MAPK3(1), MAPK7(2), MEF2A(2), MEF2C(1), MEF2D(1), NTRK1(2), PIK3CA(3), PLCG1(1), RPS6KA1(3), SHC1(1)	865160	21	13	21	15	13	6	0	1	1	0	0.753	1.000	1.000
542	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOA(1), ALDOB(4), FBP1(1), GCK(2), GMDS(1), GMPPB(1), HK2(5), HK3(3), PFKFB1(2), PMM2(1)	1089611	21	13	20	16	17	2	1	1	0	0	0.600	1.000	1.000
543	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(3), FUT2(1), FUT9(7), HEXA(2), HEXB(2), NAGA(1), ST3GAL1(2), ST8SIA1(1)	461348	19	13	19	11	12	3	0	2	2	0	0.461	1.000	1.000
544	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT7(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), CHST1(2), CHST2(3), CHST4(3), CHST6(2), FUT8(2), ST3GAL1(2)	567087	18	13	18	17	7	7	3	1	0	0	0.914	1.000	1.000
545	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(2), CHST12(2), CHST13(1), PAPSS2(2), SULT1A1(5), SULT1A2(1), SULT1E1(6), SULT2A1(4), SUOX(1)	417914	24	13	23	12	18	1	0	3	2	0	0.338	1.000	1.000
546	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	GSK3B(1), IGF1R(1), INPPL1(7), PDPK1(2), PIK3CA(3), PTEN(1), RPS6KB1(1)	899193	16	13	15	13	9	3	2	0	2	0	0.920	1.000	1.000
547	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(7), FYN(1), LRP8(2), RELN(15), VLDLR(3)	638237	28	13	28	22	21	0	1	3	3	0	0.958	1.000	1.000
548	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNGR1(2), JAK1(1), JAK2(1), PLA2G2A(1), PTPRU(7), REG1A(2), STAT1(3)	520758	17	13	17	10	9	0	0	5	3	0	0.823	1.000	1.000
549	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC3(1), CASP8(1), CFLAR(1), MAP3K3(1), MAP3K7(1), NFKB1(4), NFKBIA(1), NFKBIB(1), NFKBIL2(1), NR2C2(2), TNFRSF1A(1), TNFRSF1B(2)	1232522	17	13	17	13	11	2	1	2	1	0	0.872	1.000	1.000
550	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), CASP2(1), CASP8(1), DFFB(1), LMNA(1), MADD(3), MAP3K7(1), PAK2(2), PRKDC(6), RB1(2), SPTAN1(2), TNFRSF1A(1)	1771060	22	13	22	13	15	1	1	2	2	1	0.649	1.000	1.000
551	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), LTA(1), MAP3K14(2), NFKB1(4), NFKBIA(1), RELA(1), TNFRSF1B(2), TRAF1(2), TRAF3(3)	1021034	17	13	17	13	14	0	0	1	2	0	0.873	1.000	1.000
552	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(6), FHL5(4), FSHR(3), GNAS(4)	433275	17	12	17	17	11	3	0	3	0	0	0.983	1.000	1.000
553	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	IL4(1), MAP2K3(2), MAPK14(3), NFATC1(5), NFATC2(1), PRKACB(1), PRKAR2B(3)	552271	16	12	16	13	9	2	2	2	1	0	0.844	1.000	1.000
554	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(4), CLOCK(1), CRY1(1), CRY2(2), CSNK1E(1), NPAS2(3), PER1(3), PER3(1)	775856	16	12	16	13	9	2	1	1	3	0	0.899	1.000	1.000
555	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	HRAS(2), IGF1R(1), MAPK1(2), MAPK3(1), PIK3CA(3), RAF1(3), SHC1(1), SOS1(3)	870761	16	12	16	10	8	5	0	2	1	0	0.738	1.000	1.000
556	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(3), IL22RA1(2), JAK1(1), JAK2(1), STAT1(3), STAT3(1), STAT5A(1), STAT5B(1), TYK2(3)	833632	16	12	16	10	7	1	1	6	1	0	0.830	1.000	1.000
557	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(1), ELK1(1), HRAS(2), IL6ST(1), JAK1(1), JAK2(1), MAPK3(1), PTPN11(5), RAF1(3), SHC1(1), SOS1(3), STAT3(1)	1084381	21	12	20	11	8	7	0	4	2	0	0.694	1.000	1.000
558	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	CAT(1), GH1(1), GHR(7), HRAS(2), IGF1R(1), PIK3CA(3), SHC1(1)	607970	16	12	16	13	9	5	0	2	0	0	0.906	1.000	1.000
559	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(4), FBP1(1), G6PD(1), PGD(2), PGM1(1), PGM3(1), PRPS1L1(4), PRPS2(1), RBKS(1), TAL1(2), TALDO1(1), TKT(1)	933531	21	12	20	15	17	0	0	3	1	0	0.584	1.000	1.000
560	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	BTK(4), GRASP(1), GSK3B(1), LYN(2), PDPK1(2), PFKL(2), PLCG1(1), PRKCE(2), PRKCZ(1), RPS6KB1(1)	1115438	17	12	16	17	11	1	2	1	2	0	0.923	1.000	1.000
561	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(6), HSD17B2(2), HSD17B4(1), HSD17B7(1), HSD3B1(4)	367039	15	12	15	12	8	2	1	1	3	0	0.866	1.000	1.000
562	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(5), NR1I3(2), PTGS1(5), PTGS2(3)	246037	17	11	17	10	13	0	0	0	4	0	0.441	1.000	1.000
563	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	17	NCKAP1(1), NTRK1(2), WASF3(7), WASL(4)	682261	14	11	14	10	9	1	0	2	2	0	0.942	1.000	1.000
564	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(4), HS3ST2(1), HS3ST3A1(2), XYLT1(5)	290205	12	11	12	13	6	3	0	2	1	0	0.920	1.000	1.000
565	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGAP5(3), ARHGDIB(1), CASP1(1), CASP10(1), CASP8(1), CASP9(2), PRF1(2)	592207	12	11	11	10	9	1	1	1	0	0	0.904	1.000	1.000
566	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EGF(4), EGFR(6), HGS(2), TF(2), TFRC(1)	587547	15	11	15	15	13	0	1	1	0	0	0.970	1.000	1.000
567	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(4), EGFR(6), ERBB3(1), NRG1(2)	470025	13	11	13	16	10	0	1	1	1	0	0.996	1.000	1.000
568	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(4), HS3ST2(1), HS3ST3A1(2), XYLT1(5)	290205	12	11	12	13	6	3	0	2	1	0	0.920	1.000	1.000
569	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(2), DHRS1(2), DHRS2(1), DHRSX(2), METTL2B(2), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(3)	688789	18	11	18	14	13	2	0	3	0	0	0.877	1.000	1.000
570	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(3), ACADM(1), ACADS(2), ACADVL(1), ACSL1(1), ACSL3(2), ACSL4(2), CPT1A(1), DCI(1), EHHADH(1), HADHA(1), SCP2(1)	776177	17	11	17	10	12	0	1	3	1	0	0.831	1.000	1.000
571	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(9), ATM(2), BAX(2), CDKN1A(1), IGFBP3(1), NFKBIB(1)	913859	16	11	16	11	10	3	0	2	1	0	0.843	1.000	1.000
572	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	HRAS(2), NTRK1(2), PIK3CA(3), PLCG1(1), PRKCA(5), SHC1(1), SOS1(3)	713157	17	11	17	12	11	5	0	1	0	0	0.812	1.000	1.000
573	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(7), GNA12(1), PRKACB(1), PRKAG1(1), PRKAR2B(3)	461403	13	10	13	9	9	2	1	1	0	0	0.772	1.000	1.000
574	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(4), CDO1(2), GAD1(4), GAD2(1), GGT1(1)	260196	12	10	12	12	8	1	3	0	0	0	0.904	1.000	1.000
575	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(5), ATIC(2), FTCD(1), GART(2), MTR(2)	865658	12	10	11	7	11	0	1	0	0	0	0.608	1.000	1.000
576	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(7), CYP2C9(12)	91978	19	10	17	13	16	0	1	0	2	0	0.647	1.000	1.000
577	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(2), ACOX1(1), ACOX3(2), ELOVL5(1), FADS2(1), FASN(5), HADHA(1)	656478	13	10	13	12	7	0	1	2	3	0	0.897	1.000	1.000
578	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(1), MRPS7(1), RPL10L(3), RPL18(1), RPL18A(1), RPL19(1), RPL26(1), RPL35(1), RPL3L(2), RPS10(1), RPS18(1), RPS27(1), RPS7(1)	1032152	16	10	16	16	10	1	2	2	1	0	0.959	1.000	1.000
579	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	IFNAR1(1), IFNB1(1), NFKB1(4), RELA(1), TNFRSF11A(1), TNFSF11(1), TRAF6(2)	505644	11	10	11	9	11	0	0	0	0	0	0.856	1.000	1.000
580	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(4), PRKACB(1), PRKAR2B(3), PRKCA(5)	433169	13	9	13	13	8	3	1	1	0	0	0.963	1.000	1.000
581	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(5), AOC3(4), CES1(1)	275772	10	9	10	12	6	1	1	1	1	0	0.952	1.000	1.000
582	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT2(1), FUT9(7), ST8SIA1(1)	272198	9	9	9	6	7	1	0	1	0	0	0.606	1.000	1.000
583	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(6), GNAS(4), PRKACA(1)	297324	11	9	11	10	5	3	0	3	0	0	0.924	1.000	1.000
584	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(2), DHRS1(2), DHRS2(1), DHRSX(2), PON1(4), RDH11(1), RDH12(1), RDH13(1)	413480	14	9	13	13	9	0	0	3	2	0	0.937	1.000	1.000
585	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACOT11(2), DHRS1(2), DHRS2(1), DHRSX(2), EHHADH(1), ESCO2(2), GCDH(1), HADHA(1), MYST3(1), MYST4(1), NAT6(1), SH3GLB1(1)	1191511	16	9	16	15	10	2	1	3	0	0	0.982	1.000	1.000
586	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(3), APOBEC1(1), APOBEC3A(1), APOBEC3B(1), APOBEC3F(2), APOBEC3G(2)	337913	10	9	10	9	7	1	1	1	0	0	0.889	1.000	1.000
587	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(1), BAX(2), BIK(1), BIRC3(1), CASP7(2), CASP8(1), CASP9(2), DFFB(1)	615482	11	9	11	6	7	3	1	0	0	0	0.678	1.000	1.000
588	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(2), DHRS2(1), DHRSX(2), ESCO2(2), MYST3(1), MYST4(1), NAT6(1), SH3GLB1(1)	758980	11	8	11	13	8	1	0	2	0	0	0.996	1.000	1.000
589	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(5), GOT2(1), TAT(2), TYR(3)	214561	11	8	11	8	9	1	1	0	0	0	0.729	1.000	1.000
590	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	CREB3(1), CREB5(2), MAPK1(2), RAF1(3), SRC(1)	443463	9	8	9	10	5	1	0	1	2	0	0.960	1.000	1.000
591	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3D(2), IL2(1), IL4(1), TGFBR2(2), TGFBR3(2), TOB1(2)	481344	11	8	11	11	8	1	0	0	2	0	0.940	1.000	1.000
592	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(1), UBE2D3(1), UBE2E1(1), UBE2G2(1), UBE3A(4)	484788	9	8	9	5	6	1	0	2	0	0	0.721	1.000	1.000
593	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ASL(1), CPS1(8)	349176	9	8	9	6	7	0	0	2	0	0	0.766	1.000	1.000
594	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(3), CYP11B2(3), CYP17A1(1), HSD11B1(1), HSD11B2(1), HSD3B1(4)	314280	13	7	13	12	10	0	0	1	2	0	0.651	1.000	1.000
595	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	HRAS(2), PTK2B(2), SHC1(1), SOS1(3), SRC(1)	402255	9	7	9	6	6	2	0	1	0	0	0.740	1.000	1.000
596	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	IL4(1), IL4R(3), JAK1(1), RPS6KB1(1), SHC1(1), STAT6(4)	675845	11	7	11	11	6	1	1	0	3	0	0.931	1.000	1.000
597	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(4), CD28(1), CD3D(2), CD4(1)	145848	8	7	8	8	5	1	0	2	0	0	0.870	1.000	1.000
598	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(1), HLA-DRA(3), HLA-DRB1(2)	107163	7	6	7	5	7	0	0	0	0	0	0.548	1.000	1.000
599	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT1(1), B4GALT2(1), B4GALT3(1), FUT8(2), ST3GAL1(2)	358106	7	6	7	8	1	4	2	0	0	0	0.948	1.000	1.000
600	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(5), RANGAP1(1)	389239	6	6	6	4	4	1	0	1	0	0	0.876	1.000	1.000
601	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(3), ACADM(1), ACADS(2), HADHA(1)	251702	7	5	7	5	5	0	0	2	0	0	0.898	1.000	1.000
602	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	12	MAPK3(1), POLR2A(1), PRKACB(1), PRKAR2B(3)	552698	6	5	6	9	4	1	1	0	0	0	0.971	1.000	1.000
603	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(1), CSF1(3), LDLR(2), LPL(1)	243913	7	5	7	5	3	3	1	0	0	0	0.714	1.000	1.000
604	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(1), ALAS2(1), GATA1(1), HBB(1)	352170	4	4	4	4	4	0	0	0	0	0	0.832	1.000	1.000
605	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ7(1), NDUFA13(3)	181857	4	4	4	4	4	0	0	0	0	0	0.897	1.000	1.000
606	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(1), FUT2(1), FUT3(2)	326214	4	4	4	7	3	0	0	1	0	0	0.977	1.000	1.000
607	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(1), FURIN(2), NOTCH1(1)	421503	4	4	4	6	2	2	0	0	0	0	0.935	1.000	1.000
608	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(2), ST8SIA1(1)	259482	3	3	3	7	2	1	0	0	0	0	0.987	1.000	1.000
609	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	POLD1(1), PRPS2(1), RRM1(1)	569599	3	3	3	7	2	0	0	1	0	0	0.992	1.000	1.000
610	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(3)	83733	3	2	3	3	3	0	0	0	0	0	0.862	1.000	1.000
611	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(1)	102952	2	2	2	3	2	0	0	0	0	0	0.917	1.000	1.000
612	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(1)	193914	1	1	1	3	1	0	0	0	0	0	0.981	1.000	1.000
613	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2		75566	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
614	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4		141850	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
615	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		70711	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9		193352	0	0	0	3	0	0	0	0	0	0	1.000	1.000	1.000
