rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CDK4(1), CDKN1A(3), CDKN2A(12), E2F1(1), E2F2(2), MDM2(1), NXT1(1), PRB1(4), TP53(13)	769500	38	25	33	2	16	2	2	2	16	0	1.55e-05	1.11e-07	6.85e-05
2	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(3), CDKN2A(12), E2F1(1), MDM2(1), MYC(2), PIK3CA(1), POLR1A(3), POLR1B(1), RAC1(3), RB1(3), TBX2(3), TP53(13)	1849356	46	30	41	3	20	3	2	4	17	0	1.63e-05	0.000110	0.0339
3	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(3), CCNE2(3), CDK4(1), CDKN2A(12), E2F1(1), E2F2(2), PRB1(4)	822258	26	20	22	2	14	0	1	2	9	0	0.000955	0.00135	0.277
4	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(2), GRIA2(11), PPP1R1B(1)	332784	14	13	14	3	6	1	0	4	3	0	0.191	0.00301	0.371
5	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(2), ATM(4), BAX(2), BCL2(1), CDK4(1), CDKN1A(3), E2F1(1), MDM2(1), RB1(3), TIMP3(1), TP53(13)	1642639	32	24	31	3	12	4	2	3	11	0	0.00324	0.00301	0.371
6	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(3), ATM(4), ATR(4), CCNA1(3), CDC25A(3), CDK4(1), CDKN1A(3), CDKN2A(12), E2F1(1), RB1(3), SKP2(1), TFDP1(1), TGFB1(1), TGFB3(1), TP53(13)	2749707	54	33	49	7	24	3	3	3	21	0	0.000218	0.00362	0.372
7	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(4), FMOD(2), KERA(4), LUM(2)	319453	13	12	13	1	11	0	2	0	0	0	0.00801	0.00908	0.799
8	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(2), IFNGR1(3), IFNGR2(1), JAK2(1), LIN7A(3), NFKB1(3), RB1(3), RELA(2), TNFRSF1A(1), TNFRSF1B(2), TP53(13), USH1C(3)	1644576	37	29	36	6	15	3	2	6	11	0	0.0175	0.0169	1.000
9	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(6), ADH1C(8), ADH4(2), ADH7(5), ADHFE1(3)	515247	26	22	24	6	19	1	2	3	1	0	0.0369	0.0211	1.000
10	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	MYC(2), TP53(13)	647120	15	14	14	0	8	0	1	1	5	0	0.00546	0.0260	1.000
11	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(4), CDC25A(3), CDC25B(3), CDC25C(2), CDK4(1), MYT1(7), RB1(3), TP53(13)	1602586	36	26	35	5	19	2	2	3	10	0	0.00721	0.0458	1.000
12	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(3), CCND2(1), CCNH(2), CDC25A(3), CDK4(1), CDKN1A(3), CDKN2A(12), E2F1(1), RB1(3), RBL1(3), TFDP1(1)	1474273	33	24	29	6	14	2	2	3	12	0	0.00622	0.0950	1.000
13	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(1), CASP3(1), CASP8(2), CFLAR(3), PDE6D(1)	357732	8	8	8	1	3	1	1	2	1	0	0.209	0.109	1.000
14	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT2(3), TAT(5)	240405	8	7	8	3	4	1	1	0	2	0	0.367	0.112	1.000
15	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(2)	46983	2	2	2	0	2	0	0	0	0	0	0.459	0.142	1.000
16	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(2), GALNT2(4), GALNT3(1), GALNT4(2), GALNT6(2), GALNT8(8), GALNT9(2), GCNT1(1), ST3GAL1(2), ST3GAL4(1), WBSCR17(12)	1319494	37	27	37	7	28	3	1	4	1	0	0.00405	0.282	1.000
17	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(2), ALDH1A2(2), BCMO1(5), RDH5(1)	356527	10	10	9	3	8	0	0	2	0	0	0.210	0.288	1.000
18	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	65308	1	1	1	0	0	0	0	1	0	0	0.826	0.311	1.000
19	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	DNAJC3(1), MAP3K14(2), NFKB1(3), RELA(2), TP53(13)	885095	21	19	20	5	9	2	1	4	5	0	0.201	0.342	1.000
20	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(3), CDC25B(3), CDKN1A(3), NEK1(1)	636369	10	10	10	2	4	4	0	1	1	0	0.258	0.374	1.000
21	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(2), BAX(2), BCL2(1), BIRC2(2), BIRC3(1), CASP3(1), CASP7(3), CASP8(2), CASP9(1), CYCS(1), DFFB(1), DIABLO(1)	1232677	18	15	18	0	10	2	2	1	3	0	0.00124	0.375	1.000
22	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(2), BAX(2), BCL10(1), BCL2(1), BCL2L11(4), CASP8AP2(3), CASP9(1), CES1(5)	987403	19	13	18	2	12	3	0	1	3	0	0.0151	0.377	1.000
23	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(1), CASP7(3), DFFB(1), GZMB(1), HMGB2(1), TOP2A(3), TOP2B(2)	820989	12	10	12	1	6	0	3	2	1	0	0.0821	0.379	1.000
24	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(3), CDC34(2), CUL1(1), E2F1(1), RB1(3), SKP2(1), TFDP1(1)	778812	12	11	12	2	7	1	2	0	2	0	0.0682	0.388	1.000
25	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	PARK2(2), SNCA(1), SNCAIP(13), UBE2E2(2), UBE2F(1), UBE2L6(1)	587211	20	18	19	5	16	2	0	1	1	0	0.0722	0.408	1.000
26	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(3), ATM(4), BRCA1(3), CDKN1A(3), MDM2(1), MRE11A(1), NFKB1(3), RELA(2), TP53(13), TP73(2)	2703737	35	31	34	5	14	4	2	5	10	0	0.0221	0.408	1.000
27	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	APAF1(2), ATM(4), BAX(2), BCL2(1), CASP3(1), CASP7(3), CASP9(1), CYCS(1), PRKCA(1), PTK2(3), STAT1(2), TLN1(4), TP53(13)	2487335	38	25	37	4	19	4	3	3	9	0	0.000530	0.415	1.000
28	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(3), LPL(1), NR3C1(2), PPARG(3), RETN(1), RXRA(1)	531852	11	10	11	2	7	0	0	2	2	0	0.115	0.455	1.000
29	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(2), ACTR2(2), ACTR3(2), ARPC3(1), RAC1(3), WASF1(1), WASL(2)	743877	13	13	13	2	9	1	0	2	1	0	0.121	0.485	1.000
30	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(5), ATM(4), BAX(2), CDKN1A(3), CPB2(1), CSNK1A1(1), HIF1A(2), IGFBP3(2), MDM2(1), TP53(13)	1893463	34	26	32	7	18	3	2	3	8	0	0.0418	0.500	1.000
31	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(4), ATR(4), CDC25C(2), TP53(13)	1457357	23	19	22	4	13	0	1	1	8	0	0.109	0.529	1.000
32	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(6), DAXX(3), HRAS(1), PAX3(1), PML(2), RB1(3), SP100(1), TNFRSF1A(1), TNFRSF1B(2), TP53(13)	1715198	33	21	32	7	14	2	4	3	10	0	0.0743	0.529	1.000
33	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(2), EGR1(2), HRAS(1), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), NGFR(3), RAF1(2)	738376	19	15	19	5	11	1	1	3	3	0	0.0833	0.561	1.000
34	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	BCL2(1), EGFR(6), IGF1R(1), MYC(2), POLR2A(4), PPP2CA(1), PRKCA(1), RB1(3), TEP1(6), TERT(1), TP53(13), XRCC5(1)	2556046	40	30	39	7	21	2	5	4	8	0	0.00534	0.570	1.000
35	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(2), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(1), ST6GALNAC4(1)	519299	7	7	7	2	3	1	1	2	0	0	0.395	0.605	1.000
36	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CDC34(2), CUL1(1), E2F1(1), FBXW7(1), RB1(3), TFDP1(1)	744549	9	9	9	2	3	1	2	0	3	0	0.195	0.614	1.000
37	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(2), GOT2(3), TAT(5)	428208	10	8	10	4	5	1	2	0	2	0	0.393	0.617	1.000
38	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT2(4), AKT3(2), CDKN1A(3), HRAS(1), MAP2K1(4), MAP2K2(1), NGFR(3), NTRK1(2), PIK3CA(1), PIK3CD(1), SOS1(1)	1456738	23	16	23	2	9	5	1	4	4	0	0.00528	0.619	1.000
39	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(2), ARHGDIB(3), BIRC2(2), BIRC3(1), CASP3(1), CASP7(3), CASP8(2), CASP9(1), CYCS(1), DFFB(1), GZMB(1), LMNB1(1), LMNB2(1), PRF1(3)	1783381	23	18	23	3	13	2	2	2	4	0	0.0197	0.637	1.000
40	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYB(1), RB1(3)	610339	5	5	5	0	1	0	1	1	2	0	0.158	0.640	1.000
41	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ICAM1(1), ITGAL(3), ITGAM(3), ITGB2(4), SELE(9), SELL(1)	938592	21	19	21	6	15	0	1	2	3	0	0.0891	0.643	1.000
42	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(1), FUT2(2), FUT9(6)	548120	9	9	8	3	6	1	0	2	0	0	0.271	0.659	1.000
43	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(2), ACOX3(2), ELOVL2(1), ELOVL6(1), FASN(5), HADHA(1), HSD17B12(1), SCD(2)	1310042	15	15	15	3	8	2	1	1	3	0	0.0413	0.691	1.000
44	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(3), CD34(2), CD3D(1), CD3G(1), CD58(1), CD8A(1), CSF3(2), IL6(1), KITLG(4)	559604	16	13	16	7	9	1	1	3	2	0	0.387	0.695	1.000
45	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(1), SNAP25(3), STX1A(1)	298217	5	4	5	0	3	0	0	1	1	0	0.130	0.702	1.000
46	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1), CBS(4), MUT(1)	466792	6	6	6	0	5	1	0	0	0	0	0.0645	0.703	1.000
47	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOB(2)	360558	3	3	3	1	1	0	0	1	1	0	0.638	0.726	1.000
48	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1)	151284	1	1	1	0	0	0	0	1	0	0	0.819	0.750	1.000
49	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(1), MMP2(1), MMP9(2), RECK(1), TIMP3(1), TIMP4(1)	676964	8	8	8	1	4	0	0	3	1	0	0.227	0.772	1.000
50	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(4), HLA-DRA(3), IL1B(2), IL5(1), IL5RA(2), IL6(1)	487091	13	11	13	6	10	0	0	1	2	0	0.255	0.775	1.000
51	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(2), ACADS(2), HADHA(1)	502346	7	7	7	3	5	0	1	1	0	0	0.574	0.775	1.000
52	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	CAMP(1), DAG1(4), GNAQ(1), ITPKB(2)	549272	8	8	8	1	6	0	0	0	2	0	0.0711	0.778	1.000
53	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ICAM1(1), ITGA4(5), ITGAL(3), ITGAM(3), ITGB1(1), ITGB2(4), SELE(9), SELL(1), SELP(8)	1440142	35	25	35	9	26	0	1	4	4	0	0.0366	0.783	1.000
54	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(8), CSF1(1), FCGR3A(2), IL1B(2), IL6R(2), SELL(1), SPN(1), TGFB1(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF8(4)	1181990	25	19	24	6	19	1	2	0	3	0	0.0224	0.791	1.000
55	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(4), GAD1(3), HDC(5), TH(1), TPH1(2)	548537	15	13	15	5	11	1	1	0	2	0	0.0923	0.793	1.000
56	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(4), HLA-DRA(3), IL5(1)	277269	8	7	8	6	6	0	0	0	2	0	0.567	0.799	1.000
57	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(2), NRF1(1), UBE2D3(1), UBE2E3(1), UBE2H(1), UBE2J2(2), UBE2L6(1), UBE2M(1), UBE2S(1), UBE3A(1)	966440	12	12	12	2	7	3	0	1	1	0	0.122	0.803	1.000
58	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2)	194865	2	2	2	1	1	0	0	1	0	0	0.786	0.809	1.000
59	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(4), EGFR(6), ERBB3(1), NRG1(5)	941215	16	13	16	3	11	0	2	3	0	0	0.132	0.819	1.000
60	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), CD3D(1), CD3G(1), GZMB(1), HLA-A(2), ICAM1(1), ITGAL(3), ITGB2(4), PRF1(3)	793909	17	16	17	7	10	1	0	2	4	0	0.359	0.827	1.000
61	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	TGDS(1), UXS1(1)	354207	2	2	2	4	0	0	0	0	2	0	0.997	0.851	1.000
62	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD80(1), HLA-DRA(3), IL10(1), IL2(1)	360550	6	6	6	5	4	0	0	0	2	0	0.698	0.853	1.000
63	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1), SLPI(1)	157084	2	2	2	2	1	0	0	1	0	0	0.899	0.854	1.000
64	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(2), CDC25A(3), CDC25B(3), CDC25C(2), SHH(1)	797481	11	10	11	2	7	2	0	2	0	0	0.166	0.854	1.000
65	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(1), ENO2(2), ENO3(2), FARS2(2), GOT2(3), PAH(3), TAT(5)	761273	18	14	18	8	12	2	1	0	3	0	0.246	0.864	1.000
66	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(2), APAF1(2), BCL2(1), CASP3(1), CASP9(1), CYCS(1), DAXX(3), FAS(2), FASLG(5), IL1A(1), MAPKAPK2(2), MAPKAPK3(1)	1038936	22	17	22	5	15	3	1	2	1	0	0.0380	0.869	1.000
67	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(1)	167018	1	1	1	1	1	0	0	0	0	0	0.846	0.869	1.000
68	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(6), DFFB(1), GZMA(1), GZMB(1), HMGB2(1), PRF1(3)	970356	13	12	13	4	6	1	2	3	1	0	0.406	0.871	1.000
69	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD8A(1), CSF1(1), CSF3(2), EPO(1), IL2(1), IL5(1), IL6(1), IL7(2)	552100	10	9	10	4	7	1	0	1	1	0	0.290	0.873	1.000
70	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(6), ADH1C(8), ADH4(2), ADH5(1), ADH7(5), ADHFE1(3), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2)	1205335	35	27	33	10	24	2	5	3	1	0	0.0262	0.875	1.000
71	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	HLA-DRA(3)	215913	3	3	3	3	2	0	0	0	1	0	0.809	0.878	1.000
72	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(3), CDC25B(3), CDC25C(2), PRKCA(1), PTPRA(2)	849283	11	11	11	3	7	3	0	1	0	0	0.165	0.892	1.000
73	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1G(3), HDAC9(6), MEF2A(2), MEF2B(1), MEF2C(1), MEF2D(2), MYOD1(1)	670741	16	10	16	5	11	1	0	2	2	0	0.253	0.892	1.000
74	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(3), PLCB1(13), PRKCA(1), RELA(2)	747672	20	16	19	7	15	1	0	3	1	0	0.254	0.893	1.000
75	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(4), CDC25A(3), CDC25B(3), CDC25C(2), MYT1(7)	1254755	19	17	19	5	12	2	0	2	3	0	0.207	0.894	1.000
76	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(2), ARHGAP5(3), ARHGDIB(3), CASP3(1), CASP8(2), CASP9(1), CYCS(1), GZMB(1), PRF1(3)	1180418	17	15	17	4	11	3	0	1	2	0	0.151	0.896	1.000
77	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(1), HLCS(2)	283461	3	3	3	2	3	0	0	0	0	0	0.702	0.898	1.000
78	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNAQ(1), HTR2C(4), PLCB1(13), TUB(3)	651875	21	15	20	8	19	0	0	1	1	0	0.153	0.908	1.000
79	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT2(4), AKT3(2), CASP9(1), CHP(2), HRAS(1), KDR(10), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), MAPKAPK2(2), MAPKAPK3(1), NFAT5(2), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), NOS3(2), NRAS(62), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PLA2G1B(1), PLA2G2D(1), PLA2G2F(2), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), PLCG2(6), PPP3R2(2), PRKCA(1), PRKCG(4), PTGS2(3), PTK2(3), RAC1(3), RAF1(2), SHC2(2), SPHK2(2), VEGFA(3)	6559220	174	62	115	46	72	7	27	57	11	0	0.000386	0.920	1.000
80	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT2(2), FUT9(6), HEXA(1), HEXB(1), ST3GAL1(2), ST3GAL4(1)	923341	14	11	13	4	10	1	0	3	0	0	0.124	0.921	1.000
81	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ICAM1(1), ITGA4(5), ITGAL(3), ITGB1(1), ITGB2(4), SELE(9), SELL(1)	1093942	24	21	24	7	18	0	1	2	3	0	0.142	0.923	1.000
82	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SRP19(1), SRP68(3), SRPR(1)	699840	5	5	5	0	2	0	0	2	1	0	0.281	0.925	1.000
83	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CUL1(1), E2F1(1), RB1(3), SKP2(1), TFDP1(1), UBE2M(1)	785913	8	8	8	3	3	1	2	0	2	0	0.394	0.929	1.000
84	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	TGDS(1), UXS1(1)	451353	2	2	2	4	0	0	0	0	2	0	0.997	0.933	1.000
85	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO2(3), FH(1), IDH1(5), IDH2(1), MDH2(1)	819750	11	8	8	2	10	0	1	0	0	0	0.0688	0.933	1.000
86	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(6), F2(4), F2R(2), FGA(8), FGG(2), PLAT(3), PLG(8), SERPINB2(6)	1215849	40	28	40	13	31	2	5	2	0	0	0.0988	0.933	1.000
87	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(1), SQLE(1)	290616	2	2	2	0	2	0	0	0	0	0	0.371	0.937	1.000
88	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(1), ALPP(1), ALPPL2(4), FPGS(1)	584250	9	8	9	2	8	1	0	0	0	0	0.0726	0.941	1.000
89	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(1), POLR2A(4), POLR2B(3), POLR2E(1), POLR2F(1), POLR2J(1), POLR2L(1), POLRMT(1)	1217277	13	11	13	2	7	2	1	2	1	0	0.0618	0.941	1.000
90	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(3), G6PD(1), GCLC(2), GGT1(1), GPX5(3), GSS(1), GSTA1(1), GSTA2(1), GSTM1(1), GSTM4(1), GSTM5(3), GSTP1(1), GSTT1(1), IDH1(5), IDH2(1), PGD(2)	1645834	28	22	25	9	19	1	3	2	3	0	0.0387	0.944	1.000
91	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(1), GBA3(6), GGT1(1), SHMT2(1)	487838	10	9	9	5	7	0	0	1	2	0	0.387	0.951	1.000
92	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(4), CDKN1A(3), EPO(1), EPOR(1), GRIN1(2), HIF1A(2), JAK2(1), NFKB1(3), RELA(2)	1142600	19	17	19	6	7	4	2	2	4	0	0.291	0.953	1.000
93	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(5), CCR2(8), CCR3(4), CCR4(3), CCR7(1), CXCR3(1), CXCR4(1), IFNGR1(3), IFNGR2(1), IL12A(1), IL12RB1(3), IL12RB2(1), IL18R1(8), IL2(1), IL4R(6), IL5(1), TGFB1(1), TGFB3(1)	1815749	50	28	50	12	39	3	0	5	3	0	0.000374	0.955	1.000
94	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(4), EGFR(6), MAP2K1(4), MAP3K1(1), NCOR2(8), RXRA(1), THRA(1), THRB(4)	1562980	29	22	29	7	16	4	3	4	2	0	0.0702	0.964	1.000
95	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(3), ABL2(2), AKT2(4), AKT3(2), ARAF(2), AREG(1), BRAF(3), CAMK2B(2), CAMK2D(1), CAMK2G(1), CBL(3), CBLB(4), CBLC(2), CDKN1A(3), EGF(4), EGFR(6), ERBB2(3), ERBB3(1), ERBB4(12), EREG(1), HRAS(1), MAP2K1(4), MAP2K2(1), MAP2K4(1), MAP2K7(1), MAPK1(3), MAPK10(2), MAPK3(1), MYC(2), NCK1(1), NCK2(1), NRAS(62), NRG1(5), NRG3(6), PAK1(1), PAK6(2), PAK7(15), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PLCG2(6), PRKCA(1), PRKCG(4), PTK2(3), RAF1(2), RPS6KB1(1), RPS6KB2(2), SHC2(2), SHC3(4), SHC4(1), SOS1(1), SOS2(2), STAT5B(1)	9335940	219	62	158	52	93	14	30	66	16	0	1.65e-05	0.964	1.000
96	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF3(2), EPO(1), FLT3(6), IGF1(2), IL1A(1), IL6(1), KITLG(4), TGFB1(1), TGFB3(1)	751440	19	14	19	9	11	2	2	2	2	0	0.391	0.965	1.000
97	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BIRC3(1), CASP8(2), RIPK1(1), TNFRSF1A(1), TNFRSF1B(2)	748189	7	7	7	0	6	0	0	0	1	0	0.0520	0.966	1.000
98	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(5), GNAS(6), PRKACA(1)	591809	12	11	12	5	8	1	0	1	2	0	0.342	0.966	1.000
99	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ5(1), NDUFA13(4)	363568	6	6	6	3	5	0	1	0	0	0	0.625	0.967	1.000
100	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(3), IFNGR2(1), JAK1(1), JAK2(1), STAT1(2)	744305	8	5	8	3	2	0	0	2	4	0	0.883	0.967	1.000
101	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2)	723594	10	10	10	4	7	0	2	1	0	0	0.315	0.967	1.000
102	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2)	723594	10	10	10	4	7	0	2	1	0	0	0.315	0.967	1.000
103	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GALT1(5), B3GALT5(1), FUT2(2), FUT3(1), ST3GAL4(1)	653819	11	11	11	5	6	1	0	3	1	0	0.482	0.970	1.000
104	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(2)	386140	2	2	2	1	2	0	0	0	0	0	0.700	0.972	1.000
105	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(12), NRG3(6), PRKCA(1)	813864	19	17	18	8	13	1	1	0	4	0	0.342	0.972	1.000
106	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(5), FDPS(1), PMVK(1), SQLE(1)	1009689	8	8	8	2	5	1	0	1	1	0	0.278	0.976	1.000
107	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	IL12A(1), IL2(1)	267849	2	1	2	1	2	0	0	0	0	0	0.658	0.980	1.000
108	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(1), SQLE(1)	388533	2	2	2	0	2	0	0	0	0	0	0.380	0.981	1.000
109	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(2), BAX(2), BCL2(1), BIRC2(2), BIRC3(1), CASP3(1), CASP7(3), CASP8(2), CASP9(1), CYCS(1), FAS(2), FASLG(5), GZMB(1), MAP2K4(1), MAP3K1(1), MAP3K14(2), MAPK10(2), MCL1(1), MDM2(1), MYC(2), NFKB1(3), PRF1(3), RELA(2), RIPK1(1), TNFRSF1A(1), TNFRSF1B(2), TNFSF10(2), TP53(13), TRAF1(1)	3396336	62	33	61	11	36	6	3	8	9	0	0.000647	0.982	1.000
110	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(2), BIRC2(2), BIRC3(1), CASP3(1), CASP7(3), CASP8(2), CASP9(1), DFFB(1), GZMB(1), PRF1(3), SCAP(1), SREBF1(1), SREBF2(4)	1661646	23	21	23	8	11	1	2	4	5	0	0.337	0.982	1.000
111	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSA(1), FARSB(1), GOT2(3), PAH(3), TAT(5)	795508	15	14	15	9	10	1	1	0	3	0	0.583	0.985	1.000
112	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	APC(4), AXIN1(2), CD14(2), CTNNB1(1), FZD1(1), GJA1(2), IRAK1(1), LBP(2), LEF1(1), MYD88(1), NFKB1(3), PIK3CA(1), PPP2CA(1), RELA(2), TLR4(12)	2761278	36	25	36	6	21	4	5	2	4	0	0.00536	0.986	1.000
113	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(1), APOBEC2(1), APOBEC3B(1), APOBEC3C(2), APOBEC3F(1), APOBEC3G(1)	673115	7	6	7	3	5	0	2	0	0	0	0.483	0.988	1.000
114	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), FECH(3)	690440	4	4	4	1	3	0	0	0	1	0	0.351	0.989	1.000
115	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(2), EPHA4(6), EPHB1(7), FYN(2), ITGA1(4), ITGB1(1), LYN(1), RAP1B(1), SELP(8)	1435816	32	22	31	10	21	1	0	6	4	0	0.0945	0.991	1.000
116	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACP6(1), ALPI(2), ALPL(1), ALPP(1), ALPPL2(4), CMBL(2), CYP3A4(4), CYP3A43(4), CYP3A5(3), CYP3A7(3), DHRS2(2), DHRS3(1), DHRSX(1), PON1(4)	1637007	34	23	34	11	22	2	1	4	5	0	0.0570	0.992	1.000
117	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(11), C5(3), C6(14), C7(11), C8A(9), C9(7)	1127695	55	30	51	19	38	2	2	4	9	0	0.0591	0.992	1.000
118	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(6), GGT1(1), SHMT2(1)	368819	8	8	7	5	6	0	0	1	1	0	0.503	0.992	1.000
119	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), HADHA(1), HSD17B4(1), SIRT5(2), VNN2(5)	1082882	10	9	10	4	5	1	1	1	2	0	0.487	0.992	1.000
120	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(3), EPHX2(1), HSD3B7(2), RDH13(1)	441033	7	6	7	7	5	0	1	0	1	0	0.906	0.992	1.000
121	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(3), FH(1), IDH2(1), OGDH(2)	865998	7	6	7	2	6	0	0	0	1	0	0.390	0.992	1.000
122	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(1), CPO(1), FECH(3), GATA1(1)	702304	6	6	6	3	5	0	0	0	1	0	0.488	0.992	1.000
123	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(5), FDPS(1), PMVK(1), SQLE(1)	1202919	8	8	8	2	5	1	0	1	1	0	0.310	0.993	1.000
124	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(2), HADHA(1), HADHB(3)	763632	6	6	6	3	1	1	1	1	2	0	0.760	0.994	1.000
125	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), CD36(1), FOS(1), FYN(2), THBS1(3)	676814	8	8	8	5	5	0	0	1	2	0	0.786	0.994	1.000
126	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(2), HS3ST2(3), XYLT1(3), XYLT2(1)	576714	10	10	10	5	7	0	0	3	0	0	0.473	0.994	1.000
127	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(2), HS3ST2(3), XYLT1(3), XYLT2(1)	576714	10	10	10	5	7	0	0	3	0	0	0.473	0.994	1.000
128	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(3), DHRS2(2), DHRS3(1), DHRSX(1), HSD3B7(2), PON1(4), RDH13(1)	826595	14	10	14	7	8	1	1	2	2	0	0.510	0.994	1.000
129	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(5), AOC2(2), AOC3(2), CES1(5)	548751	14	12	13	9	11	0	0	1	2	0	0.616	0.994	1.000
130	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS2(1), SULT1A2(1), SULT1E1(3), SULT2A1(2), SUOX(1)	556824	8	5	8	3	7	0	0	1	0	0	0.440	0.994	1.000
131	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(6), JAK1(1), JAK2(1), TYK2(3)	952137	11	10	11	4	9	0	0	0	2	0	0.477	0.995	1.000
132	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(6), JAK1(1), JAK2(1), TYK2(3)	952137	11	10	11	4	9	0	0	0	2	0	0.477	0.995	1.000
133	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(4), GGT1(1), PAPSS2(1), SCLY(1), SEPHS1(2)	1140675	9	9	9	2	5	1	0	3	0	0	0.203	0.995	1.000
134	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(4), FOS(1), HRAS(1), MAP2K1(4), MAPK1(3), MAPK3(1), MYC(2), NFKB1(3), PLCB1(13), PRKCA(1), RAF1(2), RELA(2)	1420277	37	26	36	13	25	1	1	5	5	0	0.130	0.995	1.000
135	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(1), CARS2(1), CDO1(1), GOT2(3), LDHA(2), LDHAL6B(2), SULT1B1(2), SULT1C2(3), SULT1C4(1), SULT4A1(3)	1147350	19	17	19	8	13	1	2	2	1	0	0.373	0.995	1.000
136	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(5), PGAP1(2), PIGB(2), PIGF(1), PIGG(3), PIGH(1), PIGK(3), PIGO(3), PIGQ(1), PIGT(1), PIGU(2), PIGV(2), PIGZ(1)	2187391	27	22	27	7	18	2	0	3	4	0	0.0373	0.995	1.000
137	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ASL(3), CPS1(4)	696291	7	7	7	4	5	0	0	1	1	0	0.655	0.995	1.000
138	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	EIF4A1(1), EIF4A2(1), EIF4B(1), EIF4G1(3), EIF4G2(1), EIF4G3(2), FKBP1A(1), PIK3CA(1), PPP2CA(1), PTEN(4), RPS6(1), RPS6KB1(1), TSC1(1), TSC2(6)	2528227	25	18	25	8	7	4	4	3	6	1	0.374	0.995	1.000
139	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	HADHA(1), HADHB(3), HSD17B4(1), MECR(1), PPT1(1), PPT2(1)	774973	8	8	8	4	1	0	2	2	3	0	0.741	0.996	1.000
140	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(2), ADORA2A(1), ADORA2B(1), ADORA3(2), LTB4R(1), P2RY2(2)	543586	9	9	9	6	5	0	0	3	1	0	0.524	0.996	1.000
141	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(1), NR1I3(1), PTGS1(3), PTGS2(3)	491917	10	7	10	7	7	1	0	1	1	0	0.626	0.996	1.000
142	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1)	424912	1	1	1	1	1	0	0	0	0	0	0.893	0.996	1.000
143	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), IL1B(2), MST1(1), MST1R(3)	598617	7	6	7	4	4	2	0	0	1	0	0.689	0.997	1.000
144	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PRKCA(1), TGM2(1)	454737	2	2	2	2	1	0	0	0	1	0	0.745	0.997	1.000
145	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), B3GALT5(1), FUT2(2), FUT9(6), HEXA(1), HEXB(1), ST3GAL1(2)	980789	14	11	13	6	10	1	0	3	0	0	0.310	0.997	1.000
146	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(7), HLA-DRA(3), IFNGR1(3), IFNGR2(1), IL12A(1), IL12RB1(3), IL12RB2(1), IL18R1(8), IL2(1), IL2RA(1), IL4R(6)	1154944	35	18	35	10	24	3	0	3	5	0	0.0605	0.997	1.000
147	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	CYCS(1), GPD2(1), SDHC(1)	608704	3	3	3	1	3	0	0	0	0	0	0.564	0.997	1.000
148	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT5(2), FUT8(1), ST3GAL1(2), ST3GAL4(1)	716297	6	6	6	3	3	1	0	2	0	0	0.717	0.997	1.000
149	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(2), B3GAT3(1), CHPF(1), CHST11(1), CHST12(1), CHST3(1), CHSY1(1), DSE(7), XYLT1(3), XYLT2(1)	1215035	19	14	19	8	11	3	1	2	2	0	0.215	0.997	1.000
150	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(2), ACTR3(2), DAG1(4), DGKA(1), GCA(2), ITGA9(2), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(2), MAP2K1(4), MAPK1(3), MAPK3(1), NR1I3(1), PAK1(1), PDE3A(8), PDE3B(1), PI3(1), PIK3C2G(13), PIK3CA(1), PIK3CD(1), RIPK3(2), VASP(1)	4421839	67	36	66	12	43	6	2	5	11	0	1.73e-05	0.997	1.000
151	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(2), ACTR2(2), ACTR3(2), ARPC3(1), NCK1(1), NCKAP1(2), NTRK1(2), RAC1(3), WASF1(1), WASL(2)	1401108	18	18	18	5	12	1	0	3	2	0	0.295	0.998	1.000
152	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(1), FURIN(3), NOTCH1(1)	843223	5	4	5	1	1	1	0	3	0	0	0.438	0.998	1.000
153	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(1), NDUFB2(1), NDUFB5(1)	639968	3	3	3	1	3	0	0	0	0	0	0.576	0.998	1.000
154	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CSF1(1), CSF3(2), HLA-DRA(3), IFNB1(2), IL10(1), IL12A(1), IL15(1), IL1A(1), IL2(1), IL5(1), IL6(1), IL7(2), TGFB1(1), TGFB3(1)	1199617	19	14	19	9	13	1	1	2	2	0	0.266	0.998	1.000
155	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACO2(3), ACSS2(1), FH(1), IDH1(5), IDH2(1), MDH2(1)	1221803	12	9	9	3	10	0	1	0	1	0	0.0922	0.998	1.000
156	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO2(3), GRHPR(1), HAO1(2), HAO2(4), MDH2(1), MTHFD1(2)	1167312	13	12	13	5	9	1	1	1	1	0	0.277	0.998	1.000
157	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(3), EIF2AK4(3), EIF2B5(1), EIF5(1)	1064334	8	8	8	3	3	1	0	4	0	0	0.644	0.999	1.000
158	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(2), ATP6V0A4(8), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(3), ATP6V1G3(1), ATP6V1H(1), FDXR(2)	1462391	20	15	20	8	6	3	3	3	5	0	0.311	0.999	1.000
159	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(1), IL1A(1), IL1R1(5), NR4A3(2), WDR1(1)	972824	10	9	10	4	7	0	1	0	2	0	0.472	0.999	1.000
160	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	FOS(1), MAFG(1), MAPK1(3), NFE2L2(1), PRKCA(1)	809863	7	6	7	5	5	0	0	0	2	0	0.777	0.999	1.000
161	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(1), GOT2(3), LDHA(2)	626901	6	5	6	5	3	1	1	0	1	0	0.861	0.999	1.000
162	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO2(3), GRHPR(1), HAO1(2), HAO2(4), MDH2(1), MTHFD1(2)	1223009	13	12	13	5	9	1	1	1	1	0	0.271	0.999	1.000
163	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	EIF2B5(1), IGF1(2), IGF1R(1), INPPL1(4), PIK3CA(1), PPP2CA(1), PTEN(4), RPS6(1), RPS6KB1(1)	1792198	16	15	16	5	2	4	2	3	5	0	0.492	0.999	1.000
164	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), LARS(2), LARS2(2), PDHA1(1), PDHA2(2), PDHB(1)	917661	9	7	8	5	3	3	0	1	2	0	0.777	0.999	1.000
165	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	GTF2A1(1), GTF2B(3), GTF2E1(1), GTF2F1(1), HDAC3(3), NCOA1(2), NCOA3(2), NCOR2(8), POLR2A(4), RXRA(1), TBP(1)	2261262	27	19	27	8	15	2	2	4	4	0	0.178	0.999	1.000
166	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	BDH1(1), HMGCL(1), HMGCS2(3), OXCT1(1)	650980	6	4	6	8	2	2	0	1	1	0	0.989	0.999	1.000
167	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EGF(4), EGFR(6), TF(3), TFRC(1)	1171089	14	9	14	4	10	0	2	2	0	0	0.268	1.000	1.000
168	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(2), ATP6V0A4(8), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(3), ATP6V1G3(1), ATP6V1H(1)	1373936	18	15	18	8	6	2	3	2	5	0	0.388	1.000	1.000
169	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(2), ATP6V0A4(8), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(3), ATP6V1G3(1), ATP6V1H(1)	1373936	18	15	18	8	6	2	3	2	5	0	0.388	1.000	1.000
170	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(2), ATP6V0A4(8), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(3), ATP6V1G3(1), ATP6V1H(1)	1373936	18	15	18	8	6	2	3	2	5	0	0.388	1.000	1.000
171	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(3), POLR1B(1), POLR2A(4), POLR2B(3), POLR2E(1), POLR2F(1), POLR2J(1), POLR2L(1), POLR3A(1), POLR3B(2)	2140300	18	16	18	4	11	1	1	3	2	0	0.0910	1.000	1.000
172	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(2), ENO1(1), HK1(1), PKLR(2)	841089	6	5	6	4	4	1	0	0	1	0	0.613	1.000	1.000
173	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(1), JAK3(2), MAPK1(3), MAPK3(1), TYK2(3)	1059518	11	7	11	6	7	0	0	1	3	0	0.644	1.000	1.000
174	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	CBS(4), DNMT1(5), DNMT3A(3), DNMT3B(3), MTR(1)	1613540	16	11	16	3	12	2	1	0	1	0	0.0476	1.000	1.000
175	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(2), MBTPS1(3), SCAP(1), SREBF1(1), SREBF2(4)	1081212	11	10	11	9	4	0	0	4	3	0	0.942	1.000	1.000
176	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	BCAR1(1), ITGB1(1), MAPK1(3), MAPK3(1), PIK3CA(1), PTEN(4), PTK2(3), SOS1(1)	1751944	15	12	15	9	5	2	0	3	5	0	0.907	1.000	1.000
177	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(3), EGF(4), EGFR(6), HRAS(1), MAP2K1(4), MAPK1(3), MAPK3(1), PTPRB(25), RAF1(2), RASA1(3), SOS1(1), SPRY1(3), SPRY3(1), SPRY4(1)	2273958	58	32	55	15	41	5	2	4	6	0	0.0179	1.000	1.000
178	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1B(2)	572987	2	2	2	2	1	0	0	1	0	0	0.919	1.000	1.000
179	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(3), CHPT1(1), HEMK1(1), LCMT1(1), METTL2B(2), PCYT1B(2), PRMT3(2), PRMT8(1)	1282463	13	11	13	5	7	0	1	4	1	0	0.415	1.000	1.000
180	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(2), ACTR3(2), ARPC3(1), PAK1(1), PDGFRA(7), PIK3CA(1), RAC1(3), WASL(2)	1225772	19	17	19	8	11	2	0	3	3	0	0.586	1.000	1.000
181	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PRKCA(1)	615441	3	3	3	7	2	0	0	0	1	0	0.993	1.000	1.000
182	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNB1(2), JAK1(1), STAT1(2), TYK2(3)	982953	8	7	8	3	6	0	0	1	1	0	0.442	1.000	1.000
183	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), MIOX(2)	771069	10	10	10	5	5	2	3	0	0	0	0.523	1.000	1.000
184	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(3), CASP3(1), CASP8(2), CRADD(1), DFFB(1), LMNB1(1), LMNB2(1), MADD(7), MAP2K4(1), MAP3K1(1), MAP3K7(1), PAK1(1), PRKDC(3), RB1(3), RIPK1(1), SPTAN1(1), TNFRSF1A(1)	3556404	30	20	30	7	13	3	2	3	9	0	0.0580	1.000	1.000
185	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(3), HK1(1), HK2(1), HK3(2), TGDS(1)	935732	8	8	8	9	3	3	0	0	2	0	0.958	1.000	1.000
186	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(9)	777392	9	8	9	5	6	1	0	1	1	0	0.794	1.000	1.000
187	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(4), GNAQ(1), GNAS(6), HRAS(1), LIMK1(1), MAP2K1(4), MAPK1(3), MAPK3(1), MYL2(3), NOX1(4), PIK3C2G(13), PLCB1(13), PRKCA(1), PTK2(3), RAF1(2), ROCK2(2)	2279665	62	35	60	20	43	2	0	8	9	0	0.0596	1.000	1.000
188	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT2(4), AKT3(2), MAPK1(3), MAPK3(1), PDK1(1), PIK3CA(1), PIK3CD(1), PTEN(4), RBL2(1), SOS1(1)	1873851	19	16	19	9	7	3	0	4	5	0	0.645	1.000	1.000
189	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), IL10(1), IL10RB(4), IL1A(1), IL6(1), JAK1(1), STAT1(2)	1116786	11	10	10	8	5	0	1	2	3	0	0.867	1.000	1.000
190	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNGR1(3), JAK1(1), JAK2(1), PTPRU(2), REG1A(1), STAT1(2)	1041573	10	6	10	7	4	1	0	2	3	0	0.920	1.000	1.000
191	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(4), ATR(4), BRCA1(3), BRCA2(3), FANCA(2), FANCC(2), FANCD2(4), FANCF(1), FANCG(2), MRE11A(1), RAD1(1), RAD17(2), RAD9A(2), TP53(13)	4022823	44	27	43	9	28	0	1	6	9	0	0.0434	1.000	1.000
192	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(1), B3GNT3(1), B3GNT4(1), B4GALT4(2), FUT2(2), FUT3(1), FUT4(2), FUT7(2), FUT9(6), ST3GAL6(1)	1453611	19	17	18	9	10	4	0	3	2	0	0.315	1.000	1.000
193	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(4), ATR(4), BRCA1(3), CDC25A(3), CDC25B(3), CDC25C(2), CDC34(2), CDKN1A(3), EP300(4), MDM2(1), MYT1(7), PRKDC(3), RPS6KA1(3), TP53(13)	3837696	55	34	54	13	29	7	1	7	11	0	0.0316	1.000	1.000
194	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ME1(3), PC(3), PDHA1(1), SLC25A11(1)	851090	8	7	8	5	5	2	1	0	0	0	0.620	1.000	1.000
195	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(4), AXIN1(2), CTNNB1(1), DLL1(1), FZD1(1), NOTCH1(1)	1925810	10	9	10	3	3	2	1	0	4	0	0.376	1.000	1.000
196	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	HRAS(1), SOS1(1)	805026	2	2	2	7	1	0	0	0	1	0	1.000	1.000	1.000
197	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(2), BCL2(1), CASP8(2), CYCS(1), MAP2K1(4), MAP2K4(1), MAP3K1(1), MAPK1(3), MAPK3(1), NFKB1(3), NSMAF(2), RAF1(2), RELA(2), RIPK1(1), SMPD1(1), TNFRSF1A(1)	1859550	28	18	28	8	16	3	0	5	4	0	0.162	1.000	1.000
198	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(2), ATM(4), ATR(4), BAI1(4), BAX(2), CASP3(1), CASP8(2), CASP9(1), CCNB3(7), CCND2(1), CCNE2(3), CCNG1(1), CDK4(1), CDKN1A(3), CDKN2A(12), CYCS(1), EI24(2), FAS(2), GADD45B(2), GTSE1(1), IGF1(2), IGFBP3(2), LRDD(1), MDM2(1), MDM4(1), PTEN(4), RFWD2(1), SERPINB5(2), SESN2(1), SESN3(1), STEAP3(3), THBS1(3), TP53(13), TP73(2), TSC2(6), ZMAT3(1)	5904075	100	45	95	27	48	10	3	10	28	1	0.00274	1.000	1.000
199	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA3(3), ANXA5(1), ANXA6(1), CYP11A1(4), EDNRA(2), EDNRB(1), HPGD(1), HSD11B1(3), HSD11B2(1), PLA2G4A(2), PRL(1), PTGDR(2), PTGER2(1), PTGER4(1), PTGFR(6), PTGIS(5), PTGS1(3), PTGS2(3), TBXAS1(2)	1863478	43	26	43	19	27	5	0	7	4	0	0.177	1.000	1.000
200	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(4), CREBBP(6), EP300(4), MAP2K1(4), MAP3K7(1), MAPK3(1), TGFB1(1), TGFB3(1), TGFBR2(3)	2346256	25	21	25	8	14	2	1	3	5	0	0.427	1.000	1.000
201	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO2(3), DLD(1), FH(1), IDH1(5), IDH2(1), IDH3A(1), MDH2(1), PC(3), PCK1(4), SUCLG1(1)	1890667	21	18	18	8	16	0	3	1	1	0	0.181	1.000	1.000
202	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(3), HK1(1), HK2(1), HK3(2), TGDS(1)	1064934	8	8	8	9	3	3	0	0	2	0	0.954	1.000	1.000
203	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA5(1), PSMB5(1), PSMB8(2)	806242	4	4	4	3	1	0	0	2	1	0	0.938	1.000	1.000
204	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(3), CYP2A6(5), CYP2A7(2), NAT2(1), XDH(14)	733017	27	19	25	15	23	1	1	2	0	0	0.179	1.000	1.000
205	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(6), EP300(4), ESR1(1), MAPK1(3), MAPK3(1), PELP1(2)	1337367	17	14	17	7	10	2	1	2	2	0	0.488	1.000	1.000
206	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	IL2RG(1), IL4R(6), IRS1(3), JAK1(1), JAK3(2), RPS6KB1(1), STAT6(1)	1344153	15	11	15	5	7	1	2	2	3	0	0.331	1.000	1.000
207	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPN1(1), CDK5(2), CSNK1A1(1), MAPT(3), PPP2CA(1)	821024	8	7	8	6	3	0	1	3	1	0	0.881	1.000	1.000
208	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ENPP3(4), FLAD1(2)	882618	7	7	7	9	3	1	1	1	1	0	0.980	1.000	1.000
209	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), CKM(1), FBL(1), LDHA(2), NCL(2)	820709	9	8	9	5	5	1	1	1	1	0	0.723	1.000	1.000
210	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(2), DAB1(12), FYN(2), LRP8(2), RELN(17), VLDLR(1)	1269003	36	26	36	14	24	2	1	4	5	0	0.374	1.000	1.000
211	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(2), GNA12(1), PRKACG(2), PRKAG1(1), PRKAR2B(1)	920860	7	7	7	8	6	0	0	0	1	0	0.937	1.000	1.000
212	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX3(2), PLA2G1B(1), PLA2G2D(1), PLA2G2F(2), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3)	924438	16	12	16	9	13	0	0	3	0	0	0.518	1.000	1.000
213	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSS(1), NFKB1(3), NOX1(4), RELA(2), XDH(14)	899972	24	21	22	11	18	1	0	5	0	0	0.277	1.000	1.000
214	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(2), IL10(1), IL12A(1), IL15(1), IL16(3), IL1A(1), IL2(1), IL5(1), IL6(1)	898165	12	10	12	8	8	0	1	2	1	0	0.608	1.000	1.000
215	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(4), F2R(2), F2RL3(1), HRAS(1), ITGA1(4), ITGB1(1), MAP2K1(4), MAPK1(3), MAPK3(1), PLA2G4A(2), PLCB1(13), PRKCA(1), PTGS1(3), PTK2(3), RAF1(2), SYK(3), TBXAS1(2)	2220900	50	32	49	18	30	5	1	6	8	0	0.111	1.000	1.000
216	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(3), DLAT(1), DLD(1), FH(1), IDH2(1), IDH3A(1), MDH2(1), OGDH(2), PC(3), PDHA1(1), PDHA2(2), PDHB(1), PDHX(1), PDK1(1), PDK3(1), PDK4(1), PDP2(1), SDHC(1), SUCLG1(1)	2596194	25	19	24	9	17	2	3	1	2	0	0.222	1.000	1.000
217	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(1), IFNB1(2), NFKB1(3), RELA(2)	1010476	9	9	9	9	5	1	0	2	1	0	0.972	1.000	1.000
218	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1R(3), C1S(1), C2(3), C3(11), C5(3), C6(14), C7(11), C8A(9), C9(7)	1570145	62	33	58	24	44	2	2	5	9	0	0.0778	1.000	1.000
219	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	MAP2K1(4), MAP2K2(1), MAP2K3(2), MAP3K1(1), MAPK1(3), MAPK3(1), NFKB1(3), PIK3CA(1), RB1(3), RELA(2)	1763310	21	17	21	9	8	3	2	3	5	0	0.573	1.000	1.000
220	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(4), CAMP(1), CASP3(1), CERK(1), CREB5(2), DAG1(4), EPHB2(4), FOS(1), GNAQ(1), ITPKB(2), MAP2K4(1), MAP2K7(1), MAPK1(3), MAPK10(2), MAPK8IP2(2), MAPK8IP3(3)	2589233	33	26	33	11	21	0	1	2	9	0	0.152	1.000	1.000
221	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(1), JAK2(1), JAK3(2), PIAS1(1), PIAS3(1), PTPRU(2), REG1A(1)	1242685	9	9	9	7	5	1	0	1	2	0	0.892	1.000	1.000
222	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACO2(3), CLYBL(2), DLD(1), FH(1), IDH1(5), IDH2(1), IDH3A(1), MDH2(1), OGDH(2), OGDHL(9), PC(3), PCK1(4), PCK2(3), SDHC(1), SUCLG1(1)	2736336	38	26	35	10	28	2	3	2	3	0	0.0118	1.000	1.000
223	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(3), DHRS2(2), DHRS3(1), DHRSX(1), HEMK1(1), LCMT1(1), METTL2B(2), PRMT3(2), PRMT8(1)	1377768	14	12	14	8	6	1	0	5	2	0	0.747	1.000	1.000
224	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNB1(2), JAK1(1), PTPRU(2), REG1A(1), STAT1(2), TYK2(3)	1144969	11	10	11	6	8	1	0	1	1	0	0.525	1.000	1.000
225	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(2), BIRC3(1), CASP3(1), CASP8(2), CFLAR(3), MAP2K4(1), MAP3K7(1), NFKB1(3), NFKB2(2), NFKBIL2(2), RALBP1(2), RIPK1(1), TNFAIP3(1), TNFRSF1A(1), TNFRSF1B(2)	2468767	25	19	25	6	15	0	3	5	2	0	0.0961	1.000	1.000
226	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(4), COPS5(1), EP300(4), EPO(1), HIF1A(2), LDHA(2), NOS3(2), VHL(1)	1555454	17	17	17	9	8	2	2	2	3	0	0.662	1.000	1.000
227	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BRAF(3), CAMP(1), CREB5(2), MAPK1(3), RAF1(2), TERF2IP(1)	1023204	12	12	12	6	7	1	0	3	1	0	0.669	1.000	1.000
228	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(3), ATM(4), BUB1(2), CCNA1(3), CCNB3(7), CCND2(1), CCNE2(3), CCNH(2), CDC14A(2), CDC25A(3), CDC25B(3), CDC25C(2), CDC6(1), CDK4(1), CDKN1A(3), CDKN2A(12), DTX4(1), E2F1(1), E2F2(2), E2F5(1), EP300(4), ESPL1(2), HDAC3(3), HDAC4(2), HDAC5(2), HDAC8(2), MAD1L1(1), MAD2L1(1), MCM2(2), MCM3(3), MCM4(1), MCM5(1), MDM2(1), MPEG1(1), MPL(2), ORC1L(1), ORC2L(1), ORC3L(1), ORC4L(2), ORC6L(1), PLK1(2), PRKDC(3), PTPRA(2), PTTG2(2), RB1(3), RBL1(3), SKP2(1), TBC1D8(2), TFDP1(1), TGFB1(1), TP53(13)	10002051	124	53	119	25	67	12	5	16	24	0	3.34e-06	1.000	1.000
229	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR7(5), FDPS(1), GGCX(1), HSD17B7(1), PMVK(1), SQLE(1), TM7SF2(2)	1761167	12	11	12	5	5	4	1	1	1	0	0.422	1.000	1.000
230	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(2), C1GALT1(2), C1GALT1C1(1), GALNT1(2), GALNT11(1), GALNT12(3), GALNT13(11), GALNT14(5), GALNT2(4), GALNT3(1), GALNT4(2), GALNT5(2), GALNT6(2), GALNT8(8), GALNT9(2), GALNTL1(2), GALNTL2(2), GALNTL4(1), GALNTL5(3), GCNT1(1), OGT(6), ST3GAL1(2), WBSCR17(12)	2938287	77	38	75	24	50	4	2	13	8	0	0.0242	1.000	1.000
231	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(1), RPL11(1), RPL18(2), RPL27(1), RPL3(1), RPL39(1), RPL7(1), RPS13(1), RPS2(1), RPS20(1), RPS6(1)	2057062	12	12	12	5	4	2	0	4	2	0	0.499	1.000	1.000
232	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), HADHA(1)	1104332	11	11	11	6	7	0	2	2	0	0	0.560	1.000	1.000
233	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT2(4), AKT3(2), BTK(4), FCER1A(4), FYN(2), GAB2(1), HRAS(1), IL5(1), INPP5D(7), LCP2(4), LYN(1), MAP2K1(4), MAP2K2(1), MAP2K3(2), MAP2K4(1), MAP2K7(1), MAPK1(3), MAPK10(2), MAPK3(1), MS4A2(4), NRAS(62), PDK1(1), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PLA2G1B(1), PLA2G2D(1), PLA2G2F(2), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), PLCG2(6), PRKCA(1), PRKCD(1), RAC1(3), RAF1(2), SOS1(1), SOS2(2), SYK(3), VAV1(3), VAV2(2), VAV3(4)	6572391	175	62	116	53	73	7	27	57	11	0	0.00630	1.000	1.000
234	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(2), DHRS3(1), DHRSX(1), MYST3(4), MYST4(1)	1519450	9	7	9	8	4	1	0	2	2	0	0.969	1.000	1.000
235	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(11), C5(3), C6(14), C7(11), ICAM1(1), IL1A(1), IL6(1), ITGA4(5), ITGAL(3), ITGB1(1), ITGB2(4), SELP(8), SELPLG(2), VCAM1(5)	2238061	70	34	68	27	48	1	5	6	10	0	0.0539	1.000	1.000
236	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(5), ABCB11(12), ABCB4(2), ABCC1(3), ABCC3(6), GSTP1(1)	1296650	29	23	28	14	20	3	1	2	3	0	0.159	1.000	1.000
237	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(2), EPX(2), LPO(2), MPO(1), PRDX2(2), PRDX6(2), SHMT2(1), TPO(8)	1081529	21	18	21	10	16	3	1	0	1	0	0.200	1.000	1.000
238	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	CDK4(1), CDKN1A(3), E2F1(1), HRAS(1), MAPK1(3), MAPK3(1), NFKB1(3), PAK1(1), PIK3CA(1), RAC1(3), RAF1(2), RB1(3), RELA(2), TFDP1(1)	1835079	26	20	26	10	11	4	2	3	6	0	0.319	1.000	1.000
239	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	CBS(4), DNMT1(5), DNMT3A(3), DNMT3B(3), MTR(1), TAT(5)	1916032	21	14	21	8	15	2	2	0	2	0	0.230	1.000	1.000
240	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(4), AXIN1(2), BMP10(6), BMP2(1), BMP4(1), BMP5(8), BMP7(1), CHRD(3), CTNNB1(1), FZD1(1), GATA4(1), MAP3K7(1), MEF2C(1), MYL2(3), NKX2-5(1), NPPA(1), NPPB(1), TGFB1(1), TGFB3(1), TGFBR2(3), TGFBR3(3)	3297987	45	28	44	14	33	5	2	1	4	0	0.0724	1.000	1.000
241	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(1), ASL(3), CKM(1), CKMT2(1), CPS1(4), GAMT(1), GATM(1), NAGS(1), OAT(1), OTC(1), PYCR1(1)	1576353	16	15	16	8	10	3	0	1	2	0	0.478	1.000	1.000
242	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(16), CR2(7), FCGR2B(1), HLA-DRA(3), ICAM1(1), ITGAL(3), ITGB2(4), PTPRC(3)	1372646	39	29	39	16	26	4	0	3	6	0	0.283	1.000	1.000
243	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(2), ADH1A(2), ADH1B(6), ADH1C(8), ADH4(2), ADH7(5), ADHFE1(3), AKR1C4(3), AKR1D1(3), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), BAAT(4), CEL(2), CYP7A1(1), HADHB(3), SOAT2(2), SRD5A1(1), SRD5A2(1)	2123129	58	36	56	24	38	4	7	5	4	0	0.111	1.000	1.000
244	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), DDX20(2), E2F1(1), ETS1(1), ETS2(3), ETV3(1), FOS(1), HDAC5(2), HRAS(1), NCOR2(8), RBL1(3), RBL2(1), SIN3A(2), SIN3B(5)	2371371	32	25	32	12	17	4	1	5	5	0	0.219	1.000	1.000
245	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IL1A(1), IL1R1(5), IRAK1(1), MAP3K1(1), MAP3K14(2), MAP3K7(1), MYD88(1), NFKB1(3), RELA(2), RIPK1(1), TLR4(12), TNFAIP3(1), TNFRSF1A(1), TNFRSF1B(2)	2181675	34	23	34	11	24	2	3	3	2	0	0.105	1.000	1.000
246	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), ESR2(3), PDE1A(7), PDE1B(2), PLCB1(13), PLCB2(4), PRL(1), VIP(1)	1005265	32	24	31	15	25	1	0	1	5	0	0.214	1.000	1.000
247	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(6), GNAS(6), HRAS(1), IGF1R(1), ITGB1(1), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), MYC(2), NGFR(3), PDGFRA(7), PPP2CA(1), PTPRR(6), RAF1(2), RPS6KA1(3), SOS1(1)	2994956	49	30	49	18	29	3	4	8	5	0	0.167	1.000	1.000
248	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(2), CAPN1(1), CAPN2(1), CXCR3(1), EGF(4), EGFR(6), HRAS(1), ITGA1(4), ITGB1(1), MAPK1(3), MAPK3(1), MYL2(3), MYLK(11), PRKACG(2), PRKAR2B(1), PTK2(3), TLN1(4)	2954655	49	28	47	18	30	4	4	6	5	0	0.0675	1.000	1.000
249	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(1), CA1(2), CA2(2), CA3(1), CA4(1), CA6(1), CA8(2), CA9(1), CPS1(4), HAL(3)	1717519	18	15	18	9	12	2	0	1	3	0	0.469	1.000	1.000
250	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(3), DNMT1(5), MTNR1A(4), MTNR1B(2), PTGDR(2), PTGER2(1), PTGER4(1), PTGFR(6)	1017956	24	19	24	14	16	2	1	3	2	0	0.279	1.000	1.000
251	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(3), ACTG1(1), ARHGEF2(4), CD14(2), CLDN1(1), CTNNB1(1), CTTN(1), FYN(2), HCLS1(2), ITGB1(1), NCK1(1), NCK2(1), NCL(2), OCLN(1), PRKCA(1), ROCK2(2), TLR4(12), TLR5(4), TUBA3C(9), TUBA3D(5), TUBA4A(1), TUBA8(2), TUBAL3(6), TUBB2A(1), TUBB4Q(4), TUBB6(2), TUBB8(5), WAS(1), WASL(2)	4770546	80	44	77	23	54	6	4	7	9	0	0.00205	1.000	1.000
252	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(3), ACTG1(1), ARHGEF2(4), CD14(2), CLDN1(1), CTNNB1(1), CTTN(1), FYN(2), HCLS1(2), ITGB1(1), NCK1(1), NCK2(1), NCL(2), OCLN(1), PRKCA(1), ROCK2(2), TLR4(12), TLR5(4), TUBA3C(9), TUBA3D(5), TUBA4A(1), TUBA8(2), TUBAL3(6), TUBB2A(1), TUBB4Q(4), TUBB6(2), TUBB8(5), WAS(1), WASL(2)	4770546	80	44	77	23	54	6	4	7	9	0	0.00205	1.000	1.000
253	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(2), ACADS(2), ACSL1(1), ACSL3(2), CPT1A(2), CPT2(1), DCI(1), HADHA(1), SCP2(1)	1550768	15	15	15	7	10	0	2	1	2	0	0.617	1.000	1.000
254	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(6), EP300(4), LPL(1), NCOA1(2), PPARG(3), RXRA(1)	1697783	17	17	17	7	8	1	1	4	3	0	0.696	1.000	1.000
255	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	MAP3K14(2), NFKB1(3), RELA(2), TNFRSF13B(2), TNFRSF17(1), TNFSF13B(1), TRAF5(2)	1312134	13	12	13	8	6	2	0	4	1	0	0.790	1.000	1.000
256	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CARM1(3), CBS(4), GGT1(1), HEMK1(1), LCMT1(1), METTL2B(2), PAPSS2(1), PRMT3(2), PRMT8(1), SCLY(1), SEPHS1(2), SEPHS2(2)	2290480	21	18	21	8	11	2	0	7	1	0	0.278	1.000	1.000
257	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(2), BAX(2), BCL2(1), BCL2L11(4), BIRC2(2), BIRC3(1), BNIP3L(1), CASP3(1), CASP7(3), CASP8(2), CASP9(1), CYCS(1), DFFB(1), FAS(2), FASLG(5), GZMB(1), IRF2(1), IRF3(1), IRF5(1), IRF6(3), IRF7(3), MAP2K4(1), MAP3K1(1), MAPK10(2), MDM2(1), MYC(2), NFKB1(3), PLEKHG5(4), PRF1(3), RELA(2), RIPK1(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(4), TNFRSF25(1), TNFSF10(2), TP53(13), TP73(2), TRAF1(1)	5208771	85	41	84	23	54	6	5	9	11	0	0.00365	1.000	1.000
258	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	AKT2(4), AKT3(2), BTK(4), CDKN2A(12), INPP5D(7), PDK1(1), PIK3CA(1), PPP1R13B(2), PTEN(4), RPS6KA1(3), RPS6KA3(1), RPS6KB1(1), SOS1(1), SOS2(2), TEC(2)	3285372	47	31	43	16	19	4	3	6	15	0	0.165	1.000	1.000
259	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), GTF2B(3), GTF2E1(1), GTF2F2(1), POLR1A(3), POLR1B(1), POLR2A(4), POLR2B(3), POLR2E(1), POLR2F(1), POLR2J(1), POLR3B(2), POLR3E(1), TAF13(1), TAF6(1), TBP(1)	3203783	27	22	27	8	16	1	1	5	4	0	0.164	1.000	1.000
260	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CDKN1A(3), GNAQ(1), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), PRKCA(1), SYT1(4)	1907504	21	15	20	9	13	3	3	0	2	0	0.336	1.000	1.000
261	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA5(1), PSMB5(1), PSMC3(1), RPN2(1), UBE3A(1)	1187263	5	5	5	6	2	0	0	2	1	0	0.983	1.000	1.000
262	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT2(4), AKT3(2), CDKN2A(12), CREB5(2), ERBB4(12), F2RL2(1), IGF1(2), INPPL1(4), IRS1(3), IRS2(1), IRS4(2), MET(6), MYC(2), PAK1(1), PAK6(2), PAK7(15), PARD3(3), PDK1(1), PIK3CA(1), PIK3CD(1), PPP1R13B(2), PREX1(1), PTEN(4), PTK2(3), PTPN1(3), RPS6KA1(3), RPS6KA3(1), RPS6KB1(1), SLC2A4(1), SOS1(1), SOS2(2), TSC1(1), TSC2(6)	7047930	106	42	101	29	51	13	5	10	26	1	0.000774	1.000	1.000
263	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT7(2), B4GALT4(2), CHST1(1), CHST4(1), CHST6(1), FUT8(1), ST3GAL1(2), ST3GAL4(1)	1136424	11	11	11	7	5	4	0	1	1	0	0.553	1.000	1.000
264	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	HRAS(1), IGF1R(1), IRS1(3), MAP2K1(4), MAPK1(3), MAPK3(1), PIK3CA(1), RAF1(2), SOS1(1)	1735815	17	13	17	7	8	2	1	2	4	0	0.606	1.000	1.000
265	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	DLD(1), DUSP10(2), DUSP8(1), GCK(3), IL1R1(5), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K11(3), MAP3K13(1), MAP3K4(3), MAP3K5(3), MAP3K7(1), MAP3K9(6), MAPK10(2), MAPK7(2), NFATC3(1), PAPPA(20), TP53(13), ZAK(3)	4585306	73	38	71	19	50	5	3	6	9	0	0.0120	1.000	1.000
266	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(6), EP300(4), HDAC3(3), NFKB1(3), RELA(2), RIPK1(1), TNFRSF1A(1), TNFRSF1B(2)	2033808	22	15	22	8	13	2	1	5	1	0	0.395	1.000	1.000
267	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	AKT2(4), AKT3(2), DAG1(4), GNAQ(1), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(2), NFKB1(3), NFKB2(2), NFKBIL2(2), PDK1(1), PHKA2(4), PIK3CB(7), PITX2(2), PLD1(2), PLD2(3)	4087233	53	30	52	16	27	3	4	11	8	0	0.0175	1.000	1.000
268	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT2(4), AKT3(2), BCL10(1), BLNK(2), BTK(4), CARD11(8), CD19(1), CD22(4), CD72(2), CD79B(1), CHP(2), CR2(7), FCGR2B(1), FOS(1), HRAS(1), INPP5D(7), LYN(1), MALT1(1), NFAT5(2), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), NFKB1(3), NFKB2(2), NRAS(62), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PLCG2(6), PPP3R2(2), RAC1(3), RASGRP3(4), SYK(3), VAV1(3), VAV2(2), VAV3(4)	6790089	177	62	118	51	66	9	31	55	16	0	0.00267	1.000	1.000
269	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	HRAS(1), NTRK1(2), PIK3CA(1), PRKCA(1), SOS1(1)	1420129	6	5	6	6	4	1	0	0	1	0	0.966	1.000	1.000
270	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT2(4), AKT3(2), BRAF(3), EIF4B(1), FIGF(1), HIF1A(2), IGF1(2), MAPK1(3), MAPK3(1), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PRKAA2(5), RICTOR(5), RPS6(1), RPS6KA1(3), RPS6KA3(1), RPS6KA6(4), RPS6KB1(1), RPS6KB2(2), STK11(1), TSC1(1), TSC2(6), ULK1(2), ULK2(1), VEGFA(3), VEGFC(3)	4790884	78	40	77	24	43	8	3	16	7	1	0.0271	1.000	1.000
271	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(2), POLE(1), POLG(1), POLL(1), POLQ(5)	1524148	10	10	10	7	5	1	0	3	1	0	0.808	1.000	1.000
272	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(2), ACTR3(2), AKT2(4), AKT3(2), ARHGAP1(1), ARHGEF11(3), BTK(4), GDI1(1), GDI2(1), INPPL1(4), ITPR1(4), ITPR2(8), ITPR3(2), LIMK1(1), MYLK(11), MYLK2(2), PAK1(1), PAK6(2), PAK7(15), PDK1(1), PIK3CA(1), PIK3CD(1), PIK3CG(7), PITX2(2), PPP1R13B(2), PTEN(4), RACGAP1(2), ROCK2(2), SAG(2), WASF1(1), WASL(2)	6369200	97	41	95	27	51	11	3	17	15	0	0.00178	1.000	1.000
273	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(1), CAMK1G(3), FPR1(5), HRAS(1), MAP2K1(4), MAP2K2(1), MAP2K3(2), MAP3K1(1), MAPK1(3), MAPK3(1), NCF2(2), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), NFKB1(3), PAK1(1), PIK3C2G(13), PLCB1(13), RAC1(3), RAF1(2), RELA(2), SYT1(4)	3463742	76	38	74	27	49	4	4	8	11	0	0.0633	1.000	1.000
274	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(5), ITGAV(3), ITGB3(3), MAPK1(3), MAPK3(1), PDGFRA(7), PIK3CA(1), PLCB1(13), PRKCA(1), PTK2(3), RAC1(3), SMPD1(1)	2511644	44	28	43	18	31	2	0	5	6	0	0.158	1.000	1.000
275	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA5(1), PSMB5(1), PSMC3(1), PSMD1(3), PSMD13(1), PSMD2(2)	1475306	9	8	9	6	3	1	0	4	1	0	0.910	1.000	1.000
276	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(2), ARHGAP1(1), ARHGAP5(3), ARHGAP6(1), ARHGEF11(3), ARHGEF5(4), ARPC3(1), DIAPH1(2), GSN(3), LIMK1(1), MYL2(3), MYLK(11), OPHN1(1), PIP5K1A(2), PIP5K1B(6), TLN1(4), VCL(3)	4090726	53	31	51	17	38	5	3	5	2	0	0.0170	1.000	1.000
277	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	FUCA1(1), GLB1(1), HEXA(1), HEXB(1), LCT(6), NEU2(2), NEU3(1), NEU4(4)	1503807	17	15	17	9	14	1	0	1	1	0	0.519	1.000	1.000
278	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1R(3), C1S(1), C2(3), C3(11), C5(3), C6(14), C7(11), C8A(9), C9(7), MASP1(4), MASP2(3), MBL2(2)	1917766	71	34	67	29	51	4	2	5	9	0	0.0799	1.000	1.000
279	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT2(4), AKT3(2), ANKRD6(1), APC(4), AXIN1(2), CER1(2), CSNK1A1(1), CTNNB1(1), DACT1(2), DKK2(4), DKK3(1), DKK4(1), FSTL1(1), LRP1(10), NKD1(2), NKD2(1), PTPRA(2), SENP2(3), SFRP1(1), TSHB(1), WIF1(2)	3643497	48	28	48	17	28	6	1	6	7	0	0.112	1.000	1.000
280	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GCK(3), GNE(2), HEXA(1), HEXB(1), HK1(1), HK2(1), HK3(2), UAP1(1)	1549366	12	12	12	8	7	3	0	1	1	0	0.726	1.000	1.000
281	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	CASP9(1), HRAS(1), MAP2K1(4), MAPK3(1), NFKB1(3), PIK3CA(1), RAC1(3), RAF1(2), RALBP1(2), RALGDS(3), RELA(2)	1719466	23	18	23	10	14	2	0	5	2	0	0.531	1.000	1.000
282	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3D(1), CD3G(1), CXCR3(1), ETV5(3), IL12A(1), IL12RB1(3), IL12RB2(1), IL18R1(8), JAK2(1), STAT4(1), TYK2(3)	1686174	24	17	24	10	19	3	0	1	1	0	0.312	1.000	1.000
283	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(7), ACACB(7), FASN(5), MCAT(1), OLAH(4)	1447011	24	18	23	12	11	3	2	3	5	0	0.478	1.000	1.000
284	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(3), CASP3(1), CASP7(3), CASP8(2), CFLAR(3), DAXX(3), DFFB(1), FAF1(2), LMNB1(1), LMNB2(1), MAP2K4(1), MAP3K1(1), MAP3K7(1), PAK1(1), PRKDC(3), PTPN13(6), RB1(3), RIPK2(1), SPTAN1(1)	3749809	38	26	38	12	15	5	3	7	8	0	0.237	1.000	1.000
285	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(3), GNA12(1), GNAQ(1), MYL2(3), MYLK(11), PLCB1(13), PRKCA(1)	1896266	33	23	30	13	26	2	1	2	2	0	0.196	1.000	1.000
286	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(2), CALM1(1), CAPN2(1), EP300(4), MEF2D(2), NFATC1(2), NFATC2(1), PRKCA(1), SYT1(4)	2236042	18	14	17	7	12	2	3	1	0	0	0.302	1.000	1.000
287	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(3), G6PD(1), GCLC(2), GGT1(1), GPX5(3), GPX6(6), GSS(1), GSTA1(1), GSTA2(1), GSTA5(1), GSTK1(1), GSTM1(1), GSTM4(1), GSTM5(3), GSTP1(1), GSTT1(1), IDH1(5), IDH2(1)	1994055	34	23	31	17	24	1	3	3	3	0	0.201	1.000	1.000
288	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ADH1A(2), ADH1B(6), ADH1C(8), ADH4(2), ADH5(1), ADH7(5), ADHFE1(3), DHRS2(2), DHRS3(1), DHRSX(1), MYST3(4), MYST4(1)	2285577	36	26	34	14	24	2	2	5	3	0	0.303	1.000	1.000
289	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	IL2(1), MAP3K1(1), MAP3K5(3), NFKB1(3), RELA(2), TNFRSF9(1)	1746739	11	9	11	9	6	1	0	3	1	0	0.947	1.000	1.000
290	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	ATF1(1), BRAF(3), CAMP(1), CREB5(2), CREBBP(6), DAG1(4), EGR1(2), EGR2(1), EGR4(3), FRS2(1), GNAQ(1), MAP1B(5), MAP2K4(1), MAP2K7(1), MAPK1(3), MAPK10(2), MAPK3(1), MAPK8IP2(2), MAPK8IP3(3), NTRK1(2), PIK3C2G(13), PIK3CA(1), PIK3CD(1), PTPN11(1), RPS6KA3(1), TERF2IP(1), TH(1)	4656051	64	35	64	20	48	3	2	5	6	0	0.0158	1.000	1.000
291	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT2(4), AKT3(2), BCL2(1), IL4R(6), IRS1(3), IRS2(1), JAK1(1), JAK3(2), MAP4K1(2), MAPK1(3), MAPK3(1), PDK1(1), PIK3CA(1), PIK3CD(1), PPP1R13B(2), RAF1(2), SOS1(1), SOS2(2), STAT6(1)	3339432	37	20	37	13	19	6	2	5	5	0	0.189	1.000	1.000
292	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(2), BAX(2), BCL2(1), BCL2A1(1), CASP3(1), CASP7(3), CASP8(2), CASP9(1), CD40(2), CRADD(1), CYCS(1), DAXX(3), DFFB(1), FAS(2), FASLG(5), IKBKE(4), MCL1(1), NFKB1(3), NGFR(3), NR3C1(2), NTRK1(2), PTPN13(6), RIPK1(1), SFRS2IP(1), TNFRSF1A(1), TNFRSF1B(2), TRAF1(1)	3953653	55	31	55	16	33	7	1	8	6	0	0.0408	1.000	1.000
293	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(2), ACTN1(1), ACTN2(3), ACTN3(2), CAPN1(1), ITGA1(4), ITGB1(1), ITGB3(3), PTK2(3), RAC1(3), SPTAN1(1), TLN1(4)	2566859	28	23	28	13	14	2	3	4	5	0	0.244	1.000	1.000
294	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(1), APAF1(2), ARHGDIB(3), BCL2(1), BIRC2(2), BIRC3(1), CASP3(1), CASP7(3), CASP8(2), CASP9(1), CFLAR(3), CRADD(1), CYCS(1), DAXX(3), DFFB(1), GSN(3), LMNB1(1), LMNB2(1), MAP2K7(1), MAP3K1(1), MAP3K14(2), MAP3K5(3), MDM2(1), NFKB1(3), NUMA1(4), PRKCD(1), PRKDC(3), PTK2(3), RASA1(3), RB1(3), RELA(2), RIPK1(1), SPTAN1(1), TNFRSF1A(1), TNFRSF1B(2), TRAF1(1)	6313149	67	34	67	20	26	11	5	14	11	0	0.0510	1.000	1.000
295	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(1), GTF2A1L(3), GTF2B(3), GTF2E1(1), GTF2F1(1), GTF2F2(1), GTF2IRD1(2), TAF1(4), TAF13(1), TAF1L(14), TAF2(2), TAF4B(1), TAF5L(1), TAF6(1), TAF7L(2)	3297460	38	25	37	14	25	3	1	5	4	0	0.232	1.000	1.000
296	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(17), COL4A2(5), COL4A3(6), COL4A4(20), COL4A5(13), COL4A6(10), SLC23A1(1), SLC2A1(1), SLC2A3(1)	2272180	74	39	74	19	55	5	3	8	3	0	0.229	1.000	1.000
297	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	APC(4), BRAF(3), CAMP(1), DAG1(4), EGFR(6), GNA11(2), GNAQ(1), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(2), KCNJ3(4), KCNJ5(2), KCNJ9(2), MAPK1(3), MAPK10(2), PHKA2(4), PIK3CA(1), PIK3CD(1), PITX2(2), RAF1(2)	4834509	60	29	60	20	36	2	4	8	10	0	0.0481	1.000	1.000
298	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2B(2), CAMK2D(1), CAMK2G(1), DAG1(4), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(2), NFAT5(2), PDE6A(3), PDE6B(4), PDE6C(4), PDE6D(1), PDE6G(1), SLC6A13(7), TF(3)	3252132	49	28	49	21	34	0	1	6	8	0	0.0805	1.000	1.000
299	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(2), BCL2(1), BIRC2(2), BIRC3(1), CASP3(1), CASP7(3), CASP8(2), CASP9(1), CFLAR(3), CYCS(1), DFFB(1), GAS2(7), MAP3K14(2), NFKB1(3), RELA(2), RIPK1(1), SPTAN1(1), TNFRSF25(1), TNFSF10(2)	3051148	37	30	37	15	18	4	4	7	4	0	0.351	1.000	1.000
300	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(3), DIAPH1(2), FYN(2), GSN(3), HRAS(1), ITGA1(4), ITGB1(1), MAP2K1(4), MAPK1(3), MAPK3(1), MYL2(3), MYLK(11), PIK3CA(1), PTK2(3), RAF1(2), TLN1(4)	3399904	48	30	46	18	28	5	2	7	6	0	0.201	1.000	1.000
301	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(3), CARM1(3), CREBBP(6), EP300(4), ESR1(1), GRIP1(1), GTF2A1(1), GTF2E1(1), GTF2F1(1), HDAC3(3), HDAC4(2), HDAC5(2), MEF2C(1), NCOR2(8), NRIP1(1), PELP1(2), POLR2A(4), TBP(1)	4129791	45	30	45	16	26	4	3	8	4	0	0.193	1.000	1.000
302	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	DAXX(3), DDIT3(1), HMGN1(1), HRAS(1), MAP2K4(1), MAP3K1(1), MAP3K5(3), MAP3K7(1), MAP3K9(6), MAPKAPK2(2), MEF2A(2), MEF2B(1), MEF2C(1), MEF2D(2), MYC(2), PLA2G4A(2), RAC1(3), RIPK1(1), STAT1(2), TGFB1(1), TGFB3(1)	3310143	38	24	38	12	28	2	0	5	3	0	0.177	1.000	1.000
303	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), ABO(1), B3GALT1(5), B3GALT5(1), B3GNT3(1), B3GNT4(1), B4GALT4(2), FUT2(2), FUT3(1), FUT4(2), FUT7(2), FUT9(6), PIGB(2), PIGF(1), PIGG(3), PIGH(1), PIGK(3), PIGO(3), PIGQ(1), PIGT(1), PIGU(2), PIGV(2), PIGZ(1), ST3GAL1(2), ST3GAL4(1), ST3GAL5(2), ST3GAL6(1), ST6GALNAC3(2), ST6GALNAC4(1), ST8SIA5(3)	4411433	57	36	56	23	33	7	0	10	7	0	0.0868	1.000	1.000
304	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT2(4), AKT3(2), BRD4(3), CBL(3), CDKN2A(12), F2RL2(1), INPPL1(4), IRS1(3), IRS2(1), IRS4(2), LNPEP(3), MAPK1(3), MAPK3(1), PARD3(3), PDK1(1), PIK3CA(1), PIK3CD(1), PPYR1(1), PTEN(4), PTPN1(3), RAF1(2), RPS6KA1(3), RPS6KA3(1), RPS6KB1(1), SERPINB6(2), SLC2A4(1), SORBS1(5), SOS1(1), SOS2(2)	5439980	74	35	70	27	33	7	3	11	20	0	0.118	1.000	1.000
305	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(2), ABAT(4), AGXT(1), AGXT2(7), ASL(3), ASNS(1), ASPA(3), CAD(3), CRAT(2), DARS(4), GAD1(3), GAD2(1), GOT2(3), PC(3)	2385723	40	25	39	19	29	3	4	2	2	0	0.195	1.000	1.000
306	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), APC(4), CAMP(1), DAG1(4), EPHB2(4), GNAQ(1), ITPR1(4), ITPR2(8), ITPR3(2), KCNJ3(4), KCNJ5(2), KCNJ9(2), MAPK1(3), PITX2(2), RAC1(3), RYR1(15)	4149794	60	34	60	28	40	1	4	6	9	0	0.142	1.000	1.000
307	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(5), ADCY2(5), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(2), ADCY8(8), ADCY9(1), AKAP1(1), AKAP11(1), AKAP12(2), AKAP3(2), AKAP6(10), AKAP7(1), AKAP8(2), AKAP9(8), CALM1(1), GNA11(2), GNA12(1), GNA14(3), GNAI3(1), GNAO1(1), GNAQ(1), GNAZ(1), GNB3(2), GNG4(1), HRAS(1), ITPR1(4), KCNJ3(4), NRAS(62), PDE1A(7), PDE1B(2), PDE1C(11), PDE4A(3), PDE4B(3), PDE4C(4), PDE4D(1), PDE7B(6), PDE8A(1), PDE8B(2), PRKACA(1), PRKACG(2), PRKAR2B(1), PRKCA(1), PRKCD(1), PRKCG(4), PRKCH(1), PRKCI(1), PRKCQ(4), PRKCZ(2), PRKD3(2), RRAS(1), SLC9A1(2), USP5(2)	10635715	203	62	147	85	96	9	33	51	14	0	0.0851	1.000	1.000
308	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(1), ACVR1C(3), AKT2(4), AKT3(2), ARRB1(2), ARRB2(2), ATF4(2), BRAF(3), CACNA1A(7), CACNA1B(4), CACNA1C(13), CACNA1D(10), CACNA1E(24), CACNA1F(10), CACNA1G(6), CACNA1H(9), CACNA1I(10), CACNA1S(10), CACNA2D1(2), CACNA2D2(4), CACNA2D3(9), CACNA2D4(4), CACNB2(2), CACNB4(3), CACNG1(1), CACNG2(2), CACNG3(7), CACNG4(2), CACNG5(1), CACNG7(1), CACNG8(1), CASP3(1), CD14(2), CDC25B(3), CHP(2), DAXX(3), DDIT3(1), DUSP10(2), DUSP2(1), DUSP5(1), DUSP8(1), DUSP9(1), ECSIT(1), EGF(4), EGFR(6), ELK4(2), FAS(2), FASLG(5), FGF10(1), FGF12(1), FGF13(2), FGF14(1), FGF16(3), FGF19(1), FGF2(2), FGF23(2), FGF5(1), FGF6(1), FGF7(1), FGF9(1), FGFR1(4), FGFR2(10), FGFR3(2), FGFR4(5), FLNA(2), FLNB(7), FLNC(10), FOS(1), GADD45B(2), GNA12(1), HRAS(1), IL1A(1), IL1B(2), IL1R1(5), IL1R2(2), MAP2K1(4), MAP2K2(1), MAP2K3(2), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K13(1), MAP3K14(2), MAP3K4(3), MAP3K5(3), MAP3K6(1), MAP3K7(1), MAP4K1(2), MAP4K2(1), MAP4K3(3), MAP4K4(3), MAPK1(3), MAPK10(2), MAPK3(1), MAPK7(2), MAPK8IP2(2), MAPK8IP3(3), MAPKAPK2(2), MAPKAPK3(1), MAPT(3), MEF2C(1), MYC(2), NF1(7), NFATC2(1), NFATC4(7), NFKB1(3), NFKB2(2), NLK(3), NRAS(62), NTRK1(2), NTRK2(2), PAK1(1), PDGFB(2), PDGFRA(7), PDGFRB(3), PLA2G1B(1), PLA2G2D(1), PLA2G2F(2), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), PPM1A(2), PPP3R2(2), PPP5C(1), PRKACA(1), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(1), PTPN5(3), PTPRR(6), RAC1(3), RAF1(2), RAP1A(1), RAP1B(1), RAPGEF2(1), RASA1(3), RASGRF1(6), RASGRF2(3), RASGRP1(2), RASGRP2(1), RASGRP3(4), RASGRP4(1), RPS6KA1(3), RPS6KA3(1), RPS6KA6(4), RRAS(1), SOS1(1), SOS2(2), SRF(1), STMN1(1), TAOK2(5), TGFB1(1), TGFB3(1), TGFBR2(3), TNFRSF1A(1), TP53(13), ZAK(3)	25717602	531	62	469	235	306	48	40	90	47	0	0.00261	1.000	1.000
309	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(3), ABLIM1(4), ABLIM2(1), ABLIM3(1), ARHGEF12(4), CDK5(2), CHP(2), CXCL12(1), CXCR4(1), DCC(20), DPYSL5(2), EPHA1(2), EPHA2(3), EPHA3(6), EPHA4(6), EPHA5(2), EPHA6(15), EPHA7(14), EPHA8(4), EPHB1(7), EPHB2(4), EPHB3(4), EPHB4(4), EPHB6(5), FES(1), FYN(2), GNAI3(1), HRAS(1), ITGB1(1), LIMK1(1), LIMK2(4), LRRC4C(12), MAPK1(3), MAPK3(1), MET(6), NCK1(1), NCK2(1), NFAT5(2), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), NGEF(4), NRAS(62), NRP1(5), NTN4(1), NTNG1(2), PAK1(1), PAK6(2), PAK7(15), PLXNA1(3), PLXNA2(1), PLXNA3(3), PLXNB1(6), PLXNB2(2), PLXNB3(2), PLXNC1(3), PPP3R2(2), PTK2(3), RAC1(3), RASA1(3), RGS3(3), RHOD(1), RND1(1), ROBO1(7), ROBO2(11), ROBO3(3), ROCK2(2), SEMA3A(2), SEMA3D(2), SEMA3E(7), SEMA3F(3), SEMA3G(1), SEMA4A(4), SEMA4B(1), SEMA4C(2), SEMA4D(2), SEMA4G(2), SEMA5A(6), SEMA5B(4), SEMA6A(2), SEMA6B(1), SEMA6C(2), SEMA6D(1), SLIT1(5), SLIT2(17), SLIT3(6), SRGAP1(3), SRGAP2(1), SRGAP3(8), UNC5A(3), UNC5B(1), UNC5C(3), UNC5D(5)	17720266	410	62	351	148	231	32	32	80	35	0	1.75e-05	1.000	1.000
310	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTG1(1), ACTN1(1), ACTN2(3), ACTN3(2), ACTN4(3), AKT2(4), AKT3(2), ASH1L(4), CDK4(1), CGN(2), CLDN1(1), CLDN11(1), CLDN16(1), CLDN17(1), CLDN4(3), CLDN6(2), CLDN7(1), CLDN8(1), CSNK2A2(1), CTNNA2(4), CTNNA3(6), CTNNB1(1), CTTN(1), EPB41(3), EPB41L1(2), EPB41L2(3), EPB41L3(2), GNAI3(1), HCLS1(2), HRAS(1), IGSF5(3), INADL(3), JAM2(2), LLGL2(3), MAGI1(3), MAGI2(5), MAGI3(2), MLLT4(3), MPDZ(4), MYH1(19), MYH10(4), MYH11(7), MYH13(5), MYH14(3), MYH15(13), MYH2(26), MYH3(6), MYH4(23), MYH6(4), MYH7(11), MYH7B(3), MYH8(13), MYH9(7), MYL2(3), MYL7(1), MYLPF(1), NRAS(62), OCLN(1), PARD3(3), PARD6G(2), PPP2CA(1), PPP2CB(1), PPP2R2B(2), PPP2R2C(4), PPP2R3A(2), PPP2R3B(1), PRKCA(1), PRKCD(1), PRKCG(4), PRKCH(1), PRKCI(1), PRKCQ(4), PRKCZ(2), PTEN(4), RRAS(1), SPTAN1(1), SYMPK(1), TJAP1(1), TJP1(3), TJP2(3), TJP3(3), VAPA(1), ZAK(3)	17569503	352	62	291	181	191	22	33	71	35	0	0.216	1.000	1.000
311	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(5), ADCY2(5), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(2), ADCY8(8), ADCY9(1), ADRB1(1), DRD1(3), DRD2(2), EGF(4), EGFR(6), GJA1(2), GJD2(1), GNA11(2), GNAI3(1), GNAQ(1), GNAS(6), GRM1(3), GRM5(3), GUCY1A2(3), GUCY1A3(7), GUCY1B3(2), GUCY2C(8), GUCY2D(2), GUCY2F(3), HRAS(1), HTR2A(2), HTR2B(2), HTR2C(4), ITPR1(4), ITPR2(8), ITPR3(2), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), MAPK7(2), NPR1(5), NPR2(2), NRAS(62), PDGFB(2), PDGFC(2), PDGFD(1), PDGFRA(7), PDGFRB(3), PLCB1(13), PLCB2(4), PLCB4(13), PRKACA(1), PRKACG(2), PRKCA(1), PRKCG(4), PRKG1(1), PRKG2(3), PRKX(1), RAF1(2), SOS1(1), SOS2(2), TJP1(3), TUBA3C(9), TUBA3D(5), TUBA4A(1), TUBA8(2), TUBAL3(6), TUBB2A(1), TUBB4Q(4), TUBB6(2), TUBB8(5)	11965447	290	62	227	112	155	14	34	62	25	0	0.000598	1.000	1.000
312	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(2), BRAF(3), CASP3(1), CD244(2), CD247(1), CHP(2), FAS(2), FASLG(5), FCGR3A(2), FCGR3B(1), FYN(2), GZMB(1), HLA-A(2), HLA-B(1), HLA-C(1), HLA-E(1), HRAS(1), ICAM1(1), ICAM2(2), IFNA16(1), IFNA2(1), IFNA21(1), IFNA4(1), IFNA8(1), IFNB1(2), IFNGR1(3), IFNGR2(1), ITGAL(3), ITGB2(4), KIR2DL1(2), KIR3DL1(1), KIR3DL2(2), KLRC1(1), KLRC3(4), KLRK1(1), LCK(4), LCP2(4), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), MICA(1), MICB(1), NCR1(3), NCR2(5), NCR3(1), NFAT5(2), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), NRAS(62), PAK1(1), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PLCG2(6), PPP3R2(2), PRF1(3), PRKCA(1), PRKCG(4), PTPN11(1), RAC1(3), RAF1(2), SH3BP2(1), SHC2(2), SHC3(4), SHC4(1), SOS1(1), SOS2(2), SYK(3), TNFRSF10D(3), TNFSF10(2), TYROBP(2), VAV1(3), VAV2(2), VAV3(4), ZAP70(3)	10262143	241	62	181	84	123	9	29	65	15	0	0.00853	1.000	1.000
313	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT2(4), AKT3(2), BCL10(1), CARD11(8), CBL(3), CBLB(4), CBLC(2), CD247(1), CD3D(1), CD3G(1), CD8A(1), CD8B(2), CDK4(1), CHP(2), CTLA4(2), FOS(1), FYN(2), GRAP2(2), HRAS(1), IL10(1), IL2(1), IL5(1), ITK(3), LCK(4), LCP2(4), MALT1(1), MAP3K14(2), NCK1(1), NCK2(1), NFAT5(2), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), NFKB1(3), NFKB2(2), NRAS(62), PAK1(1), PAK6(2), PAK7(15), PDCD1(1), PDK1(1), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PPP3R2(2), PRKCQ(4), PTPRC(3), RASGRP1(2), SOS1(1), SOS2(2), TEC(2), VAV1(3), VAV2(2), VAV3(4), ZAP70(3)	9233253	208	62	149	68	91	16	28	61	12	0	0.0107	1.000	1.000
314	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(5), ADCY8(8), ARAF(2), ATF4(2), BRAF(3), CACNA1C(13), CALM1(1), CALML3(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CAMK4(1), CHP(2), CREBBP(6), EP300(4), GNAQ(1), GRIA1(7), GRIA2(11), GRIN1(2), GRIN2A(15), GRIN2B(11), GRIN2C(1), GRIN2D(3), GRM1(3), GRM5(3), HRAS(1), ITPR1(4), ITPR2(8), ITPR3(2), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), NRAS(62), PLCB1(13), PLCB2(4), PLCB4(13), PPP1CB(1), PPP1R1A(1), PPP3R2(2), PRKACA(1), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(1), RAF1(2), RAP1A(1), RAP1B(1), RAPGEF3(3), RPS6KA1(3), RPS6KA3(1), RPS6KA6(4)	8958123	253	62	193	103	128	15	27	65	18	0	0.0157	1.000	1.000
315	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(2), BRAF(3), CACNA1A(7), CRH(1), CRHR1(2), GNA11(2), GNA12(1), GNAI3(1), GNAO1(1), GNAQ(1), GNAS(6), GNAZ(1), GRIA1(7), GRIA2(11), GRIA3(3), GRID2(11), GRM1(3), GRM5(3), GUCY1A2(3), GUCY1A3(7), GUCY1B3(2), GUCY2C(8), GUCY2D(2), GUCY2F(3), HRAS(1), IGF1(2), IGF1R(1), ITPR1(4), ITPR2(8), ITPR3(2), LYN(1), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), NOS1(11), NOS3(2), NPR1(5), NPR2(2), NRAS(62), PLA2G1B(1), PLA2G2D(1), PLA2G2F(2), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), PLCB1(13), PLCB2(4), PLCB4(13), PPP2CA(1), PPP2CB(1), PPP2R2B(2), PPP2R2C(4), PRKCA(1), PRKCG(4), PRKG1(1), PRKG2(3), RAF1(2), RYR1(15)	9940618	279	62	215	133	149	12	28	67	23	0	0.137	1.000	1.000
316	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ACTN1(1), ACTN2(3), ACTN3(2), ACTN4(3), APC(4), APC2(2), ARAF(2), ARHGEF12(4), ARHGEF4(2), ARHGEF6(3), ARHGEF7(2), ARPC3(1), BCAR1(1), BDKRB2(3), BRAF(3), CD14(2), CHRM2(6), CHRM3(3), CHRM4(2), CYFIP1(3), CYFIP2(7), DIAPH1(2), DIAPH2(1), DIAPH3(4), DOCK1(5), EGF(4), EGFR(6), F2(4), F2R(2), FGD1(1), FGD3(2), FGF10(1), FGF12(1), FGF13(2), FGF14(1), FGF16(3), FGF19(1), FGF2(2), FGF23(2), FGF5(1), FGF6(1), FGF7(1), FGF9(1), FGFR1(4), FGFR2(10), FGFR3(2), FGFR4(5), FN1(5), GIT1(2), GNA12(1), GRLF1(1), GSN(3), HRAS(1), IQGAP1(1), IQGAP2(6), IQGAP3(3), ITGA1(4), ITGA10(3), ITGA11(4), ITGA2(4), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(5), ITGA6(2), ITGA7(6), ITGA8(9), ITGA9(2), ITGAD(4), ITGAE(2), ITGAL(3), ITGAM(3), ITGAV(3), ITGAX(1), ITGB1(1), ITGB2(4), ITGB3(3), ITGB4(5), ITGB5(2), ITGB6(3), ITGB7(2), ITGB8(3), LIMK1(1), LIMK2(4), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), MYH10(4), MYH14(3), MYH9(7), MYL2(3), MYL7(1), MYLK(11), MYLK2(2), MYLPF(1), NCKAP1(2), NCKAP1L(6), NRAS(62), PAK1(1), PAK6(2), PAK7(15), PDGFB(2), PDGFRA(7), PDGFRB(3), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PIP4K2B(1), PIP5K1A(2), PIP5K1B(6), PIP5K1C(2), PPP1CB(1), PTK2(3), RAC1(3), RAF1(2), ROCK2(2), RRAS(1), SCIN(2), SLC9A1(2), SOS1(1), SOS2(2), SSH1(3), SSH2(2), SSH3(1), TIAM1(5), TIAM2(7), TMSL3(1), VAV1(3), VAV2(2), VAV3(4), VCL(3), WAS(1), WASF1(1), WASL(2)	25024397	470	62	407	204	269	30	35	96	40	0	0.00971	1.000	1.000
317	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(7), ACACB(7), AKT2(4), AKT3(2), ARAF(2), BRAF(3), CALM1(1), CALML3(1), CBL(3), CBLB(4), CBLC(2), EXOC7(1), FASN(5), FBP2(1), FOXO1(1), G6PC(2), G6PC2(1), GCK(3), GYS2(5), HRAS(1), INPP5D(7), INSR(2), IRS1(3), IRS2(1), IRS4(2), LIPE(1), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK10(2), MAPK3(1), NRAS(62), PCK1(4), PCK2(3), PDE3A(8), PDE3B(1), PHKA1(3), PHKA2(4), PHKB(1), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PKLR(2), PKM2(1), PPARGC1A(5), PPP1CB(1), PPP1R3A(14), PPP1R3B(1), PRKAA2(5), PRKAB2(1), PRKACA(1), PRKACG(2), PRKAG1(1), PRKAG2(1), PRKAG3(5), PRKAR2B(1), PRKCI(1), PRKCZ(2), PRKX(1), PTPN1(3), PTPRF(5), PYGB(1), PYGL(3), PYGM(3), RAF1(2), RAPGEF1(4), RHOQ(1), RPS6(1), RPS6KB1(1), RPS6KB2(2), SH2B2(2), SHC2(2), SHC3(4), SHC4(1), SLC2A4(1), SOCS3(1), SORBS1(5), SOS1(1), SOS2(2), SREBF1(1), TRIP10(1), TSC1(1), TSC2(6)	14551933	288	62	230	97	144	19	35	73	16	1	0.000713	1.000	1.000
318	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(5), ADCY2(5), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(2), ADCY8(8), ADCY9(1), ATF4(2), CACNA1C(13), CACNA1D(10), CACNA1F(10), CACNA1S(10), CALM1(1), CALML3(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CGA(1), EGFR(6), FSHB(2), GNA11(2), GNAQ(1), GNAS(6), GNRH2(1), HRAS(1), ITPR1(4), ITPR2(8), ITPR3(2), MAP2K1(4), MAP2K2(1), MAP2K3(2), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K4(3), MAPK1(3), MAPK10(2), MAPK3(1), MAPK7(2), MMP14(1), MMP2(1), NRAS(62), PLA2G1B(1), PLA2G2D(1), PLA2G2F(2), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), PLCB1(13), PLCB2(4), PLCB4(13), PLD1(2), PLD2(3), PRKACA(1), PRKACG(2), PRKCA(1), PRKCD(1), PRKX(1), RAF1(2), SOS1(1), SOS2(2)	11467135	256	62	195	104	129	15	33	59	20	0	0.00744	1.000	1.000
319	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(5), ADCY2(5), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(2), ADCY8(8), ADCY9(1), CALM1(1), CALML3(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CREB3L1(1), CREB3L2(2), CREB3L3(1), CREBBP(6), CTNNB1(1), DVL2(3), EDNRB(1), EP300(4), FZD1(1), FZD2(1), FZD5(1), FZD7(1), FZD8(1), FZD9(1), GNAI3(1), GNAO1(1), GNAQ(1), GNAS(6), HRAS(1), KIT(2), KITLG(4), LEF1(1), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), MITF(2), NRAS(62), PLCB1(13), PLCB2(4), PLCB4(13), PRKACA(1), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(1), RAF1(2), TCF7L1(1), TYRP1(2), WNT10A(2), WNT11(1), WNT3(1), WNT3A(4), WNT4(1), WNT5A(1), WNT5B(1), WNT7A(2), WNT8B(3), WNT9B(1)	9829237	208	62	149	88	93	9	29	58	19	0	0.0891	1.000	1.000
320	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(7), ADORA1(2), ADORA2A(1), ADORA2B(1), ADORA3(2), ADRA1A(1), ADRA2B(3), ADRB1(1), ADRB2(1), AGTR1(4), AGTR2(2), AVPR1B(3), BDKRB2(3), C3AR1(3), C5AR1(2), CALCR(4), CALCRL(4), CCKAR(4), CCKBR(5), CGA(1), CHRM2(6), CHRM3(3), CHRM4(2), CNR1(3), CRHR1(2), CYSLTR1(2), DRD1(3), DRD2(2), DRD3(3), DRD5(3), EDNRA(2), EDNRB(1), F2(4), F2R(2), F2RL1(6), F2RL2(1), F2RL3(1), FPR1(5), FSHB(2), FSHR(3), GABBR1(1), GABBR2(3), GABRA1(2), GABRA2(1), GABRA3(8), GABRA4(1), GABRA6(3), GABRB1(3), GABRB2(1), GABRB3(5), GABRD(1), GABRE(3), GABRG1(9), GABRG2(3), GABRG3(2), GABRP(3), GABRQ(3), GABRR1(1), GALR1(2), GH2(1), GHR(4), GHRHR(1), GLP1R(3), GLP2R(4), GLRA1(2), GLRA3(3), GLRB(11), GPR156(3), GPR35(1), GPR50(5), GPR63(3), GPR83(1), GRIA1(7), GRIA2(11), GRIA3(3), GRIA4(4), GRID1(3), GRID2(11), GRIK1(4), GRIK3(3), GRIK4(2), GRIK5(2), GRIN1(2), GRIN2A(15), GRIN2B(11), GRIN2C(1), GRIN2D(3), GRIN3A(8), GRIN3B(1), GRM1(3), GRM2(2), GRM3(13), GRM4(3), GRM5(3), GRM6(5), GRM7(10), GRM8(4), GRPR(1), GZMA(1), HCRTR2(11), HRH1(3), HRH2(2), HRH4(1), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(1), HTR1F(2), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(1), HTR5A(7), HTR7(2), LEPR(7), LHCGR(7), LTB4R(1), MC2R(1), MC3R(1), MC4R(1), MC5R(1), MCHR1(1), MCHR2(8), MTNR1A(4), MTNR1B(2), NMBR(2), NMUR2(1), NPBWR2(5), NPFFR2(2), NPY1R(5), NPY2R(3), NPY5R(6), NR3C1(2), NTSR2(1), OPRK1(3), OPRM1(1), OXTR(2), P2RX1(1), P2RX3(2), P2RX5(1), P2RX7(2), P2RY10(1), P2RY13(2), P2RY14(3), P2RY2(2), P2RY8(3), PARD3(3), PPYR1(1), PRL(1), PRLR(5), PRSS1(9), PRSS3(2), PTGDR(2), PTGER2(1), PTGER3(2), PTGER4(1), PTGFR(6), PTH2R(3), RXFP1(6), RXFP2(6), SCTR(1), SSTR1(5), SSTR2(2), SSTR4(3), SSTR5(1), TAAR1(2), TAAR2(1), TAAR5(3), TAAR6(3), TAAR8(2), TAAR9(1), TACR1(1), TACR2(2), TACR3(4), THRA(1), THRB(4), TRHR(5), TSHB(1), TSHR(1), UTS2R(1), VIPR1(1), VIPR2(2)	19998309	564	61	553	370	389	39	21	60	55	0	0.0741	1.000	1.000
321	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTG1(1), CHAD(2), COL11A1(16), COL11A2(8), COL17A1(6), COL1A1(9), COL1A2(7), COL2A1(9), COL3A1(18), COL4A1(17), COL4A2(5), COL4A4(20), COL4A6(10), COL5A1(15), COL5A2(10), COL5A3(15), COL6A1(2), COL6A2(3), COL6A3(15), COL6A6(13), DES(2), DSC1(10), DSC2(15), DSC3(15), DSG1(16), DSG2(6), DSG3(11), DSG4(13), FN1(5), GJA1(2), GJA10(4), GJA4(2), GJA5(1), GJA8(3), GJB1(1), GJB3(1), GJB5(1), GJB6(3), GJD2(1), IBSP(1), ITGA6(2), ITGB4(5), KRT1(4), KRT10(4), KRT12(1), KRT13(4), KRT14(1), KRT15(3), KRT16(5), KRT17(2), KRT2(3), KRT20(2), KRT23(2), KRT24(3), KRT25(4), KRT27(1), KRT28(1), KRT3(3), KRT31(2), KRT32(2), KRT33A(2), KRT33B(1), KRT34(1), KRT35(3), KRT36(4), KRT37(2), KRT38(2), KRT39(2), KRT4(4), KRT40(1), KRT5(4), KRT6A(4), KRT6B(3), KRT6C(2), KRT7(2), KRT71(2), KRT72(1), KRT73(4), KRT74(2), KRT75(1), KRT76(2), KRT77(3), KRT78(8), KRT8(1), KRT81(1), KRT82(1), KRT83(4), KRT84(5), KRT85(2), KRT9(6), LAMA1(8), LAMA2(18), LAMA3(13), LAMA4(4), LAMA5(4), LAMB1(1), LAMB2(5), LAMB3(10), LAMB4(4), LAMC1(2), LAMC2(7), LAMC3(2), LMNB1(1), LMNB2(1), NES(4), RELN(17), SPP1(3), THBS1(3), THBS2(2), THBS3(2), THBS4(2), TNC(2), TNN(12), TNR(21), TNXB(29), VIM(1), VTN(1), VWF(9)	22767024	636	60	631	255	460	41	15	60	60	0	0.000172	1.000	1.000
322	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(5), ADCY2(5), ADCY4(1), ADCY7(2), ADCY8(8), ADCY9(1), ADORA2A(1), ADORA2B(1), ADRA1A(1), ADRB1(1), ADRB2(1), AGTR1(4), ATP2A1(1), ATP2A2(2), ATP2A3(3), ATP2B1(1), ATP2B2(5), ATP2B3(1), ATP2B4(1), AVPR1B(3), BDKRB2(3), CACNA1A(7), CACNA1B(4), CACNA1C(13), CACNA1D(10), CACNA1E(24), CACNA1F(10), CACNA1G(6), CACNA1H(9), CACNA1I(10), CACNA1S(10), CALM1(1), CALML3(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CAMK4(1), CCKAR(4), CCKBR(5), CHP(2), CHRM2(6), CHRM3(3), CHRNA7(1), CYSLTR1(2), DRD1(3), EDNRA(2), EDNRB(1), EGFR(6), ERBB2(3), ERBB3(1), ERBB4(12), F2R(2), GNA11(2), GNA14(3), GNAQ(1), GNAS(6), GRIN1(2), GRIN2A(15), GRIN2C(1), GRIN2D(3), GRM1(3), GRM5(3), GRPR(1), HRH1(3), HRH2(2), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(1), HTR5A(7), HTR7(2), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(2), LHCGR(7), MYLK(11), MYLK2(2), NOS1(11), NOS3(2), OXTR(2), P2RX1(1), P2RX3(2), P2RX5(1), P2RX7(2), PDE1A(7), PDE1B(2), PDE1C(11), PDGFRA(7), PDGFRB(3), PHKA1(3), PHKA2(4), PHKB(1), PLCB1(13), PLCB2(4), PLCB4(13), PLCD3(3), PLCE1(11), PLCG2(6), PLCZ1(6), PPP3R2(2), PRKACA(1), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(1), PTGER3(2), PTGFR(6), RYR1(15), RYR2(20), RYR3(16), SLC25A6(1), SLC8A1(8), SLC8A2(3), SLC8A3(12), SPHK2(2), TACR1(1), TACR2(2), TACR3(4), TNNC1(2), TRHR(5), TRPC1(1), VDAC2(1)	24235662	540	60	530	334	378	38	22	51	51	0	0.0778	1.000	1.000
323	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTG1(1), ACTN1(1), ACTN2(3), ACTN3(2), ACTN4(3), AKT2(4), AKT3(2), ARHGAP5(3), BCAR1(1), BCL2(1), BIRC2(2), BIRC3(1), BRAF(3), CAPN2(1), CCND2(1), CHAD(2), COL11A1(16), COL11A2(8), COL1A1(9), COL1A2(7), COL2A1(9), COL3A1(18), COL4A1(17), COL4A2(5), COL4A4(20), COL4A6(10), COL5A1(15), COL5A2(10), COL5A3(15), COL6A1(2), COL6A2(3), COL6A3(15), COL6A6(13), CTNNB1(1), DIAPH1(2), DOCK1(5), EGF(4), EGFR(6), ERBB2(3), FIGF(1), FLNA(2), FLNB(7), FLNC(10), FLT1(9), FN1(5), FYN(2), GRLF1(1), HGF(7), HRAS(1), IBSP(1), IGF1(2), IGF1R(1), ITGA1(4), ITGA10(3), ITGA11(4), ITGA2(4), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(5), ITGA6(2), ITGA7(6), ITGA8(9), ITGA9(2), ITGAV(3), ITGB1(1), ITGB3(3), ITGB4(5), ITGB5(2), ITGB6(3), ITGB7(2), ITGB8(3), KDR(10), LAMA1(8), LAMA2(18), LAMA3(13), LAMA4(4), LAMA5(4), LAMB1(1), LAMB2(5), LAMB3(10), LAMB4(4), LAMC1(2), LAMC2(7), LAMC3(2), MAP2K1(4), MAPK1(3), MAPK10(2), MAPK3(1), MET(6), MYL2(3), MYL7(1), MYLK(11), MYLK2(2), MYLPF(1), PAK1(1), PAK6(2), PAK7(15), PARVB(2), PARVG(1), PDGFB(2), PDGFC(2), PDGFD(1), PDGFRA(7), PDGFRB(3), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PIP5K1C(2), PPP1CB(1), PRKCA(1), PRKCG(4), PTEN(4), PTK2(3), RAC1(3), RAF1(2), RAP1A(1), RAP1B(1), RAPGEF1(4), RELN(17), ROCK2(2), SHC2(2), SHC3(4), SHC4(1), SOS1(1), SOS2(2), SPP1(3), THBS1(3), THBS2(2), THBS3(2), THBS4(2), TLN1(4), TLN2(6), TNC(2), TNN(12), TNR(21), TNXB(29), VASP(1), VAV1(3), VAV2(2), VAV3(4), VCL(3), VEGFA(3), VEGFC(3), VTN(1), VWF(9), ZYX(1)	33805023	713	59	703	270	494	48	20	78	73	0	1.37e-05	1.000	1.000
324	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(5), CD36(1), CHAD(2), COL11A1(16), COL11A2(8), COL1A1(9), COL1A2(7), COL2A1(9), COL3A1(18), COL4A1(17), COL4A2(5), COL4A4(20), COL4A6(10), COL5A1(15), COL5A2(10), COL5A3(15), COL6A1(2), COL6A2(3), COL6A3(15), COL6A6(13), DAG1(4), FN1(5), FNDC1(9), FNDC3A(4), FNDC4(1), FNDC5(1), GP5(3), GP6(1), HMMR(1), HSPG2(4), IBSP(1), ITGA1(4), ITGA10(3), ITGA11(4), ITGA2(4), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(5), ITGA6(2), ITGA7(6), ITGA8(9), ITGA9(2), ITGAV(3), ITGB1(1), ITGB3(3), ITGB4(5), ITGB5(2), ITGB6(3), ITGB7(2), ITGB8(3), LAMA1(8), LAMA2(18), LAMA3(13), LAMA4(4), LAMA5(4), LAMB1(1), LAMB2(5), LAMB3(10), LAMB4(4), LAMC1(2), LAMC2(7), LAMC3(2), RELN(17), SDC1(2), SDC2(1), SPP1(3), SV2A(5), SV2B(6), SV2C(2), THBS1(3), THBS2(2), THBS3(2), THBS4(2), TNC(2), TNN(12), TNR(21), TNXB(29), VTN(1), VWF(9)	20446731	502	59	499	187	362	27	14	49	50	0	0.00149	1.000	1.000
325	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(5), BDKRB2(3), C1R(3), C1S(1), C2(3), C3(11), C3AR1(3), C4BPA(8), C4BPB(3), C5(3), C5AR1(2), C6(14), C7(11), C8A(9), C8B(9), C9(7), CD59(1), CFB(12), CFH(13), CFI(7), CPB2(1), CR1(16), CR2(7), F10(2), F11(3), F13A1(6), F13B(6), F2(4), F2R(2), F5(7), F7(3), F8(6), F9(4), FGA(8), FGG(2), KLKB1(6), KNG1(3), MASP1(4), MASP2(3), MBL2(2), PLAT(3), PLAUR(1), PLG(8), PROS1(2), SERPINA1(2), SERPINA5(2), SERPINC1(1), SERPIND1(1), SERPINF2(3), SERPING1(3), TFPI(4), THBD(1), VWF(9)	8215770	263	59	259	108	179	20	14	23	27	0	0.0199	1.000	1.000
326	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(5), ADCY2(5), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(2), ADCY8(8), ADCY9(1), ADRA1A(1), ADRB1(1), ADRB2(1), ANXA6(1), ARRB1(2), ARRB2(2), ATP1A4(3), ATP2A2(2), ATP2A3(3), ATP2B1(1), ATP2B2(5), ATP2B3(1), CACNA1A(7), CACNA1B(4), CACNA1C(13), CACNA1D(10), CACNA1E(24), CACNA1S(10), CALM1(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CAMK4(1), CASQ1(2), CHRM2(6), CHRM3(3), CHRM4(2), GJA1(2), GJA4(2), GJA5(1), GJB1(1), GJB3(1), GJB5(1), GJB6(3), GNA11(2), GNAI3(1), GNAO1(1), GNAQ(1), GNAZ(1), GNB3(2), GNB4(1), GNG2(1), GNG4(1), GRK4(3), GRK5(1), GRK6(1), ITPR1(4), ITPR2(8), ITPR3(2), KCNB1(6), KCNJ3(4), KCNJ5(2), NME7(2), PKIA(1), PRKACA(1), PRKAR2B(1), PRKCA(1), PRKCD(1), PRKCG(4), PRKCH(1), PRKCQ(4), PRKCZ(2), RGS14(1), RGS16(2), RGS18(3), RGS3(3), RGS5(1), RGS6(1), RGS7(9), RGS9(2), RYR1(15), RYR2(20), RYR3(16), SLC8A1(8), SLC8A3(12), USP5(2)	16945211	302	57	297	209	210	21	15	27	29	0	0.624	1.000	1.000
327	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1B(1), ACVR2A(1), AMHR2(4), BMP2(1), BMP7(1), BMPR1B(2), CCL14(1), CCL20(1), CCL22(1), CCL26(1), CCL27(1), CCL7(1), CCR1(5), CCR2(8), CCR3(4), CCR4(3), CCR7(1), CCR8(2), CCR9(2), CD27(1), CD40(2), CSF1(1), CSF2RA(3), CSF2RB(3), CSF3(2), CSF3R(1), CX3CL1(3), CX3CR1(3), CXCL12(1), CXCL14(1), CXCL3(1), CXCL6(1), CXCR3(1), CXCR4(1), CXCR6(1), EDAR(3), EGF(4), EGFR(6), EPO(1), EPOR(1), FAS(2), FASLG(5), FLT1(9), FLT3(6), FLT4(5), GDF5(1), GH2(1), GHR(4), HGF(7), IFNA16(1), IFNA2(1), IFNA21(1), IFNA4(1), IFNA8(1), IFNB1(2), IFNGR1(3), IFNGR2(1), IFNK(1), IFNW1(3), IL10(1), IL10RB(4), IL12A(1), IL12RB1(3), IL12RB2(1), IL15(1), IL17A(1), IL17RA(2), IL18R1(8), IL18RAP(3), IL19(1), IL1A(1), IL1B(2), IL1R1(5), IL1R2(2), IL2(1), IL20(1), IL20RA(4), IL21(2), IL21R(4), IL22(1), IL22RA1(2), IL23R(1), IL28B(1), IL2RA(1), IL2RG(1), IL3RA(1), IL4R(6), IL5(1), IL5RA(2), IL6(1), IL6R(2), IL6ST(2), IL7(2), IL7R(6), INHBA(3), INHBB(1), INHBC(1), INHBE(2), KDR(10), KIT(2), KITLG(4), LEPR(7), LIF(2), LIFR(10), LTB(1), MET(6), MPL(2), NGFR(3), OSM(1), OSMR(10), PDGFB(2), PDGFC(2), PDGFRA(7), PDGFRB(3), PLEKHO2(3), PPBP(1), PRL(1), PRLR(5), RELT(1), TGFB1(1), TGFB3(1), TGFBR2(3), TNFRSF10D(3), TNFRSF11B(3), TNFRSF12A(1), TNFRSF13B(2), TNFRSF14(1), TNFRSF17(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(4), TNFRSF25(1), TNFRSF8(4), TNFRSF9(1), TNFSF10(2), TNFSF13B(1), TNFSF14(3), TNFSF18(2), TNFSF4(2), TPO(8), TSLP(1), VEGFA(3), VEGFC(3), XCL2(1), XCR1(1)	16059984	361	57	357	168	259	21	10	36	35	0	0.00825	1.000	1.000
328	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(2), ACTA2(2), ADCY1(5), ADCY2(5), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(2), ADCY8(8), ADCY9(1), ARRB1(2), ARRB2(2), ATF1(1), ATF4(2), ATF5(3), ATP2A2(2), ATP2A3(3), CALM1(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CORIN(9), CRH(1), CRHR1(2), DGKZ(1), ETS2(3), FOS(1), GABPB2(2), GBA2(1), GJA1(2), GNAQ(1), GNB3(2), GNB4(1), GNG2(1), GNG4(1), GRK4(3), GRK5(1), GRK6(1), GSTO1(1), GUCA2B(1), GUCY1A3(7), IGFBP3(2), IL1B(2), IL6(1), ITPR1(4), ITPR2(8), ITPR3(2), MYL2(3), MYL4(2), MYLK2(2), NFKB1(3), NOS1(11), NOS3(2), OXTR(2), PDE4B(3), PDE4D(1), PKIA(1), PLCG2(6), PRKACA(1), PRKAR2B(1), PRKCA(1), PRKCD(1), PRKCH(1), PRKCQ(4), PRKCZ(2), RAMP3(1), RGS14(1), RGS16(2), RGS18(3), RGS3(3), RGS5(1), RGS6(1), RGS7(9), RGS9(2), RYR1(15), RYR2(20), RYR3(16), SLC8A1(8), TNXB(29), USP5(2)	15827885	271	57	265	159	183	20	13	31	24	0	0.314	1.000	1.000
329	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(2), ADORA2A(1), ADORA2B(1), ADORA3(2), ADRA1A(1), ADRB1(1), ADRB2(1), AGTR1(4), AGTR2(2), AVPR1B(3), BDKRB2(3), C3AR1(3), CCKAR(4), CCKBR(5), CCR1(5), CCR2(8), CCR3(4), CCR4(3), CCR7(1), CCR8(2), CCR9(2), CCRL2(2), CHRM2(6), CHRM3(3), CHRM4(2), CMKLR1(2), CNR1(3), CX3CR1(3), CXCR3(1), CXCR4(1), DRD1(3), DRD2(2), DRD3(3), DRD5(3), EDNRA(2), EDNRB(1), F2R(2), F2RL1(6), F2RL2(1), F2RL3(1), FPR1(5), FSHR(3), GALR1(2), GNB2L1(2), GPR174(3), GPR27(1), GPR3(1), GPR35(1), GPR37L1(3), GPR4(1), GPR50(5), GPR63(3), GPR77(1), GPR83(1), GPR87(2), GRPR(1), HCRTR2(11), HRH1(3), HRH2(2), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(1), HTR1F(2), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(1), HTR5A(7), HTR7(2), LHCGR(7), LTB4R(1), MC3R(1), MC4R(1), MC5R(1), MTNR1A(4), MTNR1B(2), NMBR(2), NMUR2(1), NPY1R(5), NPY2R(3), NPY5R(6), NTSR2(1), OPN1SW(1), OPRK1(3), OPRM1(1), OR10A5(1), OR11A1(1), OR12D3(2), OR1C1(1), OR1F1(2), OR1Q1(2), OR2H1(2), OR5V1(6), OR7A5(2), OR8B8(3), OXTR(2), P2RY10(1), P2RY13(2), P2RY14(3), P2RY2(2), PPYR1(1), PTGDR(2), PTGER2(1), PTGER4(1), PTGFR(6), RGR(1), SSTR1(5), SSTR2(2), SSTR4(3), SUCNR1(1), TRHR(5)	11010850	281	56	278	204	184	21	13	38	25	0	0.0924	1.000	1.000
330	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(2), ACTA2(2), ACTN2(3), ACTN3(2), ACTN4(3), DES(2), DMD(4), MYBPC1(4), MYBPC2(4), MYBPC3(4), MYH3(6), MYH6(4), MYH7(11), MYH8(13), MYL1(1), MYL2(3), MYL4(2), MYOM1(10), NEB(20), TNNI2(1), TNNT2(1), TNNT3(1), TTN(251), VIM(1)	12025657	355	56	344	149	256	25	15	32	25	2	0.00695	1.000	1.000
331	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(2), ADH1B(6), ADH1C(8), ADH4(2), ADH5(1), ADH7(5), ADHFE1(3), AKR1C2(1), AKR1C3(3), AKR1C4(3), ALDH3A1(1), ALDH3B2(1), CYP1A1(3), CYP1A2(2), CYP2B6(5), CYP2C18(5), CYP2C19(17), CYP2C8(8), CYP2C9(9), CYP2E1(1), CYP2F1(1), CYP2S1(1), CYP3A4(4), CYP3A43(4), CYP3A5(3), CYP3A7(3), EPHX1(2), GSTA1(1), GSTA2(1), GSTA5(1), GSTK1(1), GSTM1(1), GSTM4(1), GSTM5(3), GSTP1(1), GSTT1(1), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A7(4), UGT1A8(1), UGT2A1(5), UGT2A3(8), UGT2B10(5), UGT2B11(6), UGT2B15(5), UGT2B28(11), UGT2B4(12), UGT2B7(6)	5198281	183	55	179	83	131	9	17	9	16	1	0.00943	1.000	1.000
332	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	CADM3(1), CD2(3), CD22(4), CD226(3), CD276(1), CD34(2), CD40(2), CD58(1), CD6(1), CD80(1), CD86(7), CD8A(1), CD8B(2), CDH15(3), CDH2(2), CDH4(4), CLDN1(1), CLDN11(1), CLDN16(1), CLDN17(1), CLDN4(3), CLDN6(2), CLDN7(1), CLDN8(1), CNTN1(4), CNTN2(3), CNTNAP1(4), CNTNAP2(19), CTLA4(2), GLG1(1), HLA-A(2), HLA-B(1), HLA-C(1), HLA-DMA(2), HLA-DOA(1), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(2), HLA-DRA(3), HLA-DRB5(1), HLA-E(1), HLA-F(4), ICAM1(1), ICAM2(2), ITGA4(5), ITGA6(2), ITGA8(9), ITGA9(2), ITGAL(3), ITGAM(3), ITGAV(3), ITGB1(1), ITGB2(4), ITGB7(2), ITGB8(3), JAM2(2), MAG(3), MPZ(1), NCAM1(3), NCAM2(1), NEGR1(1), NEO1(1), NFASC(5), NLGN1(2), NLGN2(1), NLGN3(3), NRXN1(6), NRXN2(3), NRXN3(4), OCLN(1), PDCD1(1), PTPRC(3), PTPRF(5), PTPRM(2), PVRL2(3), PVRL3(2), SDC1(2), SDC2(1), SELE(9), SELL(1), SELP(8), SELPLG(2), SIGLEC1(4), SPN(1), VCAM1(5), VCAN(6)	13323066	235	55	233	140	150	18	11	27	29	0	0.618	1.000	1.000
333	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT2(4), AKT3(2), CBL(3), CBLB(4), CBLC(2), CCND2(1), CREBBP(6), CSF2RA(3), CSF2RB(3), CSF3(2), CSF3R(1), EP300(4), EPO(1), EPOR(1), GH2(1), GHR(4), IFNA16(1), IFNA2(1), IFNA21(1), IFNA4(1), IFNA8(1), IFNB1(2), IFNGR1(3), IFNGR2(1), IFNK(1), IFNW1(3), IL10(1), IL10RB(4), IL12A(1), IL12RB1(3), IL12RB2(1), IL15(1), IL19(1), IL2(1), IL20(1), IL20RA(4), IL21(2), IL21R(4), IL22(1), IL22RA1(2), IL23R(1), IL28B(1), IL2RA(1), IL2RG(1), IL3RA(1), IL4R(6), IL5(1), IL5RA(2), IL6(1), IL6R(2), IL6ST(2), IL7(2), IL7R(6), JAK1(1), JAK2(1), JAK3(2), LEPR(7), LIF(2), LIFR(10), MPL(2), MYC(2), OSM(1), OSMR(10), PIAS1(1), PIAS3(1), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PRL(1), PRLR(5), PTPN11(1), SOCS3(1), SOCS5(1), SOCS7(1), SOS1(1), SOS2(2), SPRED1(2), SPRY1(3), SPRY3(1), SPRY4(1), STAT1(2), STAT4(1), STAT5B(1), STAT6(1), TPO(8), TSLP(1), TYK2(3)	13229277	208	55	204	104	139	17	7	26	19	0	0.380	1.000	1.000
334	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ABL1(3), ANAPC1(3), ANAPC10(1), ANAPC2(2), ANAPC4(2), ANAPC7(1), ATM(4), ATR(4), BUB1(2), CCNA1(3), CCNB3(7), CCND2(1), CCNE2(3), CCNH(2), CDC14A(2), CDC16(1), CDC25A(3), CDC25B(3), CDC25C(2), CDC27(5), CDC6(1), CDK4(1), CDKN1A(3), CDKN2A(12), CREBBP(6), CUL1(1), DBF4(1), E2F1(1), E2F2(2), EP300(4), ESPL1(2), FZR1(2), GADD45B(2), MAD1L1(1), MAD2L1(1), MCM2(2), MCM3(3), MCM4(1), MCM5(1), MDM2(1), ORC1L(1), ORC2L(1), ORC3L(1), ORC4L(2), ORC6L(1), PKMYT1(1), PLK1(2), PRKDC(3), PTTG2(2), RB1(3), RBL1(3), RBL2(1), SKP2(1), SMAD2(1), SMAD3(1), SMC1A(2), SMC1B(5), TFDP1(1), TGFB1(1), TGFB3(1), TP53(13)	12441225	149	54	144	40	76	12	11	18	32	0	0.000738	1.000	1.000
335	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(2), ADCY1(5), ADCY2(5), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(2), ADCY8(8), ADCY9(1), ADK(1), ADSSL1(1), AK2(1), AK5(2), AK7(5), ALLC(2), AMPD1(5), AMPD2(1), AMPD3(7), ATIC(1), CANT1(3), DGUOK(1), ENPP3(4), ENTPD1(1), ENTPD3(2), ENTPD4(1), ENTPD6(1), ENTPD8(1), GART(4), GDA(3), GMPR2(1), GMPS(1), GUCY1A2(3), GUCY1A3(7), GUCY1B3(2), GUCY2C(8), GUCY2D(2), GUCY2F(3), NME6(1), NME7(2), NPR1(5), NPR2(2), NT5C1A(1), NT5C1B(4), NT5C2(1), PAPSS2(1), PDE10A(3), PDE11A(2), PDE1A(7), PDE1C(11), PDE2A(4), PDE3B(1), PDE4A(3), PDE4B(3), PDE4C(4), PDE4D(1), PDE5A(2), PDE6D(1), PDE6G(1), PDE7B(6), PDE8A(1), PDE8B(2), PFAS(2), PKLR(2), PKM2(1), POLA1(1), POLA2(3), POLD1(2), POLD3(1), POLE(1), POLE2(1), POLR1A(3), POLR1B(1), POLR2A(4), POLR2B(3), POLR2E(1), POLR2F(1), POLR2J(1), POLR2L(1), POLR3A(1), POLR3B(2), PRIM2(3), PRPS1L1(4), RRM1(1), XDH(14)	14882484	225	53	223	113	150	15	10	33	17	0	0.135	1.000	1.000
336	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(3), AMY2B(2), ASCC3(1), DDX18(1), DDX19A(1), DDX23(1), DDX4(2), DDX41(1), DDX50(2), DDX51(2), DDX52(1), DHX58(1), ENPP3(4), EP400(6), G6PC(2), G6PC2(1), GAA(4), GBA(1), GBA3(6), GBE1(2), GCK(3), GYS2(5), HK1(1), HK2(1), HK3(2), IFIH1(2), MGAM(31), MOV10L1(5), PYGB(1), PYGL(3), PYGM(3), RUVBL2(1), SETX(3), SI(19), SKIV2L2(1), SMARCA2(4), SMARCA5(1), TREH(1), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A7(4), UGT1A8(1), UGT2A1(5), UGT2A3(8), UGT2B10(5), UGT2B11(6), UGT2B15(5), UGT2B28(11), UGT2B4(12), UGT2B7(6), UXS1(1)	11168753	200	53	197	95	137	17	11	14	20	1	0.124	1.000	1.000
337	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(4), APC2(2), AXIN1(2), CACYBP(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CCND2(1), CER1(2), CHD8(2), CHP(2), CREBBP(6), CSNK1A1(1), CSNK1A1L(1), CSNK2A2(1), CTNNB1(1), CUL1(1), CXXC4(1), DAAM1(2), DAAM2(1), DKK2(4), DKK4(1), DVL2(3), EP300(4), FZD1(1), FZD2(1), FZD5(1), FZD7(1), FZD8(1), FZD9(1), LEF1(1), LRP5(3), LRP6(5), MAP3K7(1), MAPK10(2), MYC(2), NFAT5(2), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), NKD1(2), NKD2(1), NLK(3), PLCB1(13), PLCB2(4), PLCB4(13), PORCN(1), PPARD(1), PPP2CA(1), PPP2CB(1), PPP2R2B(2), PPP2R2C(4), PPP3R2(2), PRICKLE1(1), PRICKLE2(2), PRKACA(1), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(1), RAC1(3), ROCK2(2), SENP2(3), SFRP1(1), SFRP2(3), SMAD2(1), SMAD3(1), TBL1X(1), TBL1Y(1), TCF7L1(1), TP53(13), VANGL2(1), WIF1(2), WNT10A(2), WNT11(1), WNT3(1), WNT3A(4), WNT4(1), WNT5A(1), WNT5B(1), WNT7A(2), WNT8B(3), WNT9B(1)	14627284	191	53	186	97	123	13	11	23	21	0	0.399	1.000	1.000
338	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(1), CALML3(1), CDS2(1), DGKA(1), DGKB(5), DGKD(2), DGKE(4), DGKG(4), DGKH(2), DGKI(4), DGKQ(2), DGKZ(1), INPP5A(1), INPP5B(1), INPP5D(7), INPPL1(4), ITPK1(2), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(2), OCRL(1), PI4KA(6), PI4KB(1), PIK3C2A(3), PIK3C2B(5), PIK3C2G(13), PIK3C3(2), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PIP4K2B(1), PIP5K1A(2), PIP5K1B(6), PIP5K1C(2), PLCB1(13), PLCB2(4), PLCB4(13), PLCD3(3), PLCE1(11), PLCG2(6), PLCZ1(6), PRKCA(1), PRKCG(4), PTEN(4), SYNJ1(3), SYNJ2(2)	11283173	191	52	186	70	123	10	5	29	24	0	0.00128	1.000	1.000
339	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT3(2), BCAR1(1), CAPN1(1), CAPN10(1), CAPN11(2), CAPN2(1), CAPN3(4), CAPN5(2), CAPN6(2), CAPN9(3), DOCK1(5), FYN(2), GIT2(2), ITGA10(3), ITGA11(4), ITGA2(4), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(5), ITGA6(2), ITGA7(6), ITGA8(9), ITGA9(2), ITGAD(4), ITGAE(2), ITGAL(3), ITGAM(3), ITGAV(3), ITGAX(1), ITGB1(1), ITGB2(4), ITGB3(3), ITGB4(5), ITGB5(2), ITGB6(3), ITGB7(2), ITGB8(3), MAP2K1(4), MAP2K2(1), MAP2K3(2), MAPK10(2), MAPK4(4), MAPK6(2), MAPK7(2), MYLK2(2), PAK1(1), PAK6(2), PTK2(3), RAC1(3), RAP1B(1), RAPGEF1(4), ROCK2(2), SHC3(4), SORBS1(5), SOS1(1), TLN1(4), TNS1(2), VASP(1), VAV2(2), VAV3(4), VCL(3), ZYX(1)	12111128	174	51	172	76	118	14	4	22	16	0	0.0368	1.000	1.000
340	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(3), ACTN1(1), ACTR2(2), ACTR3(2), AKT2(4), AKT3(2), ARHGEF6(3), ARHGEF7(2), BCAR1(1), BRAF(3), CDKN2A(12), DOCK1(5), EPHB2(4), FYN(2), GRLF1(1), ITGA1(4), ITGA10(3), ITGA11(4), ITGA2(4), ITGA3(3), ITGA4(5), ITGA5(5), ITGA6(2), ITGA7(6), ITGA8(9), ITGA9(2), MAP2K4(1), MAP2K7(1), MAP3K11(3), MAPK1(3), MAPK10(2), MAPK8IP2(2), MAPK8IP3(3), MYLK(11), MYLK2(2), PAK1(1), PAK6(2), PAK7(15), PIK3CA(1), PIK3CB(7), PKLR(2), PLCG2(6), PTEN(4), PTK2(3), RAF1(2), ROCK2(2), SOS1(1), SOS2(2), TERF2IP(1), TLN1(4), TLN2(6), VASP(1), WAS(1), ZYX(1)	11083458	184	50	175	64	111	16	6	22	29	0	0.00152	1.000	1.000
341	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(4), CCNA1(3), CCND2(1), CCNE2(3), CCNH(2), CDC25A(3), CDK4(1), CDKN1A(3), CDKN2A(12), CREB3L1(1), CREB3L3(1), E2F1(1), E2F2(2), E2F5(1), GBA2(1), MCM2(2), MCM3(3), MCM4(1), MCM5(1), MDM2(1), MYC(2), MYT1(7), ORC1L(1), ORC2L(1), ORC3L(1), ORC4L(2), ORC6L(1), POLA2(3), POLE(1), POLE2(1), RB1(3), RBL1(3), RPA1(1), TFDP1(1), TFDP2(2), TNXB(29), TP53(13)	7201772	119	49	114	36	66	6	5	18	24	0	0.00373	1.000	1.000
342	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AKT2(4), AKT3(2), APAF1(2), ATM(4), BAX(2), BCL2(1), BIRC2(2), BIRC3(1), CAPN1(1), CAPN2(1), CASP3(1), CASP7(3), CASP8(2), CASP9(1), CFLAR(3), CHP(2), CSF2RB(3), CYCS(1), DFFB(1), FAS(2), FASLG(5), IL1A(1), IL1B(2), IL1R1(5), IL3RA(1), IRAK1(1), IRAK2(3), IRAK3(2), IRAK4(2), MAP3K14(2), MYD88(1), NFKB1(3), NFKB2(2), NTRK1(2), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PPP3R2(2), PRKACA(1), PRKACG(2), PRKAR2B(1), RELA(2), RIPK1(1), TNFRSF10D(3), TNFRSF1A(1), TNFSF10(2), TP53(13)	7566004	119	49	117	45	68	9	7	19	16	0	0.0712	1.000	1.000
343	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(3), CD14(2), CD19(1), CD1A(2), CD1B(4), CD1C(6), CD1D(2), CD1E(2), CD2(3), CD22(4), CD33(4), CD34(2), CD36(1), CD3D(1), CD3G(1), CD5(3), CD59(1), CD8A(1), CD8B(2), CR1(16), CR2(7), CSF1(1), CSF2RA(3), CSF3(2), CSF3R(1), DNTT(2), EPO(1), EPOR(1), FCER2(1), FCGR1A(3), FLT3(6), GP5(3), HLA-DRA(3), HLA-DRB5(1), IL1A(1), IL1B(2), IL1R1(5), IL1R2(2), IL2RA(1), IL3RA(1), IL4R(6), IL5(1), IL5RA(2), IL6(1), IL6R(2), IL7(2), IL7R(6), ITGA1(4), ITGA2(4), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(5), ITGA6(2), ITGAM(3), ITGB3(3), KIT(2), KITLG(4), MME(5), MS4A1(2), TFRC(1), THPO(1), TPO(8)	7401774	182	49	179	89	138	8	7	8	21	0	0.122	1.000	1.000
344	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(1), ACTN2(3), ACTN3(2), ACTN4(3), ARHGAP5(3), BCAR1(1), CLDN1(1), CLDN11(1), CLDN16(1), CLDN17(1), CLDN4(3), CLDN6(2), CLDN7(1), CLDN8(1), CTNNA2(4), CTNNA3(6), CTNNB1(1), CXCL12(1), CXCR4(1), CYBA(1), GNAI3(1), GRLF1(1), ICAM1(1), ITGA4(5), ITGAL(3), ITGAM(3), ITGB1(1), ITGB2(4), ITK(3), JAM2(2), MLLT4(3), MMP2(1), MMP9(2), MYL2(3), MYL7(1), MYLPF(1), NCF2(2), NOX1(4), OCLN(1), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), PLCG2(6), PRKCA(1), PRKCG(4), PTK2(3), PTPN11(1), RAC1(3), RAP1A(1), RAP1B(1), RAPGEF3(3), RAPGEF4(7), RASSF5(1), ROCK2(2), TXK(3), VASP(1), VAV1(3), VAV2(2), VAV3(4), VCAM1(5), VCL(3)	11242629	154	49	149	97	101	10	5	23	15	0	0.768	1.000	1.000
345	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(3), AMY2B(2), ENPP3(4), G6PC(2), GAA(4), GANAB(1), GBA3(6), GBE1(2), GCK(3), GYS2(5), HK1(1), HK2(1), HK3(2), MGAM(31), PYGB(1), PYGL(3), PYGM(3), SI(19), UCHL3(1), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A7(4), UGT1A8(1), UGT2B15(5), UGT2B4(12), UXS1(1)	5163780	122	49	120	65	88	15	5	5	8	1	0.343	1.000	1.000
346	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	BCL2(1), CABIN1(2), CALM1(1), CAMK2B(2), CAMK4(1), CD3G(1), CDKN1A(3), CNR1(3), CREBBP(6), CTLA4(2), EGR2(1), EP300(4), FCER1A(4), FCGR3A(2), FOS(1), GATA3(3), GATA4(1), GRLF1(1), HRAS(1), IFNB1(2), IL10(1), IL1B(2), IL2(1), IL2RA(1), IL6(1), ITK(3), MAP2K7(1), MEF2A(2), MEF2B(1), MEF2D(2), MYF5(2), NCK2(1), NFAT5(2), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), NFKB2(2), NPPB(1), NUP214(1), P2RX7(2), PAK1(1), PPIA(1), PTPRC(3), RELA(2), TGFB1(1), TRPV6(6), VAV1(3), VAV2(2), VAV3(4), XPO5(5)	8300230	107	48	106	48	70	7	6	11	13	0	0.184	1.000	1.000
347	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(1), ALG10(2), ALG10B(1), ALG13(2), ALG2(2), ALG3(2), ALG8(1), B3GNT7(2), B4GALT4(2), B4GALT5(2), C1GALT1(2), C1GALT1C1(1), CHPF(1), CHST1(1), CHST11(1), CHST12(1), CHST3(1), CHST4(1), CHST6(1), CHSY1(1), DDOST(1), EXT2(1), EXTL1(1), EXTL3(1), FUT11(1), FUT8(1), GALNT1(2), GALNT11(1), GALNT12(3), GALNT13(11), GALNT14(5), GALNT2(4), GALNT3(1), GALNT4(2), GALNT5(2), GALNT6(2), GALNT8(8), GALNT9(2), GALNTL1(2), GALNTL2(2), GALNTL4(1), GALNTL5(3), GANAB(1), GCNT1(1), HS3ST1(2), HS3ST2(3), HS3ST5(1), HS6ST3(2), MAN1A1(4), MAN1A2(2), MAN1B1(1), MAN1C1(1), MAN2A1(2), MGAT2(2), MGAT3(3), MGAT4A(1), MGAT5(2), NDST2(1), NDST3(5), NDST4(8), OGT(6), RPN2(1), ST3GAL1(2), ST3GAL4(1), STT3B(2), WBSCR17(12), XYLT1(3), XYLT2(1)	9945386	155	48	153	81	89	12	10	27	17	0	0.414	1.000	1.000
348	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(4), ABCA10(6), ABCA12(14), ABCA13(17), ABCA3(3), ABCA4(11), ABCA5(1), ABCA6(4), ABCA7(2), ABCA8(4), ABCA9(4), ABCB1(5), ABCB10(1), ABCB11(12), ABCB4(2), ABCB5(1), ABCB7(1), ABCB8(1), ABCB9(2), ABCC1(3), ABCC10(1), ABCC11(4), ABCC12(2), ABCC2(2), ABCC3(6), ABCC4(5), ABCC5(1), ABCC6(4), ABCC8(10), ABCC9(7), ABCD2(4), ABCD3(2), ABCG1(3), ABCG2(1), ABCG4(1), ABCG5(1), ABCG8(3), CFTR(11), TAP1(1), TAP2(1)	10736055	168	48	166	112	109	13	11	19	16	0	0.605	1.000	1.000
349	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(3), CPEB1(2), EGFR(6), ERBB2(3), ERBB4(12), ETS1(1), ETS2(3), ETV6(4), FMN2(16), MAP2K1(4), MAPK1(3), MAPK3(1), NOTCH1(1), NOTCH2(9), NOTCH3(6), NOTCH4(13), PIWIL1(6), PIWIL2(2), PIWIL4(1), RAF1(2), SOS1(1), SOS2(2), SPIRE1(1), SPIRE2(2)	4793779	104	48	104	32	68	5	5	16	10	0	0.0204	1.000	1.000
350	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1B(1), ACVR1C(3), ACVR2A(1), ACVRL1(2), AMHR2(4), BMP2(1), BMP4(1), BMP5(8), BMP6(2), BMP7(1), BMP8A(1), BMPR1B(2), CHRD(3), CREBBP(6), CUL1(1), DCN(4), E2F5(1), EP300(4), GDF5(1), INHBA(3), INHBB(1), INHBC(1), INHBE(2), LEFTY1(1), LTBP1(8), MAPK1(3), MAPK3(1), MYC(2), PITX2(2), PPP2CA(1), PPP2CB(1), PPP2R2B(2), PPP2R2C(4), RBL1(3), RBL2(1), ROCK2(2), RPS6KB1(1), RPS6KB2(2), SMAD1(1), SMAD2(1), SMAD3(1), SMAD6(3), SMURF1(1), SMURF2(3), TFDP1(1), TGFB1(1), TGFB3(1), TGFBR2(3), THBS1(3), THBS2(2), THBS3(2), THBS4(2), ZFYVE16(2), ZFYVE9(1)	9051523	116	48	116	49	76	9	8	13	10	0	0.203	1.000	1.000
351	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(1), ACTG1(1), ACTN1(1), ACTN2(3), ACTN3(2), ACTN4(3), ACVR1B(1), ACVR1C(3), CREBBP(6), CSNK2A2(1), CTNNA2(4), CTNNA3(6), CTNNB1(1), EGFR(6), EP300(4), ERBB2(3), FGFR1(4), FYN(2), IGF1R(1), INSR(2), IQGAP1(1), LEF1(1), LMO7(8), MAP3K7(1), MAPK1(3), MAPK3(1), MET(6), MLLT4(3), NLK(3), PARD3(3), PTPN1(3), PTPRB(25), PTPRF(5), PTPRJ(1), PTPRM(2), PVRL2(3), PVRL3(2), RAC1(3), SMAD2(1), SMAD3(1), SORBS1(5), SSX2IP(1), TCF7L1(1), TGFBR2(3), TJP1(3), VCL(3), WAS(1), WASF1(1), WASL(2)	10949269	151	48	147	68	96	9	9	16	21	0	0.225	1.000	1.000
352	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT2(4), AKT3(2), CASP8(2), CD14(2), CD40(2), CD80(1), CD86(7), FOS(1), IFNA16(1), IFNA2(1), IFNA21(1), IFNA4(1), IFNA8(1), IFNB1(2), IKBKE(4), IL12A(1), IL1B(2), IL6(1), IRAK1(1), IRAK4(2), IRF3(1), IRF5(1), IRF7(3), LBP(2), MAP2K1(4), MAP2K2(1), MAP2K3(2), MAP2K4(1), MAP2K7(1), MAP3K7(1), MAPK1(3), MAPK10(2), MAPK3(1), MYD88(1), NFKB1(3), NFKB2(2), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIK3R3(1), PIK3R5(3), RAC1(3), RELA(2), RIPK1(1), SPP1(3), STAT1(2), TICAM1(3), TLR2(3), TLR3(2), TLR4(12), TLR5(4), TLR6(1), TLR7(3), TLR8(5), TLR9(5)	8132845	137	48	136	49	86	7	7	21	16	0	0.00578	1.000	1.000
353	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(1), CLK2(2), COL2A1(9), CPSF1(3), CPSF3(2), CSTF2(2), DDIT3(1), DDX20(2), DHX15(1), DHX16(3), DHX38(1), DHX8(3), DHX9(1), DICER1(7), DNAJC8(1), GIPC1(2), LOC440563(5), LSM2(1), METTL3(1), NONO(1), NUDT21(1), PABPN1(1), PAPOLA(2), PHF5A(1), POLR2A(4), PPM1G(1), PRPF18(1), PRPF4B(2), PRPF8(2), RBM5(3), RNMT(3), RNPS1(1), SF3A1(2), SF3B1(3), SF3B2(1), SF3B4(2), SF4(3), SFRS12(1), SFRS14(3), SFRS4(2), SFRS5(1), SFRS6(1), SFRS8(2), SFRS9(1), SNRPA(1), SNRPA1(1), SNRPB(1), SNRPD1(1), SNURF(1), SPOP(1), SRPK1(1), SRRM1(2), SUPT5H(3), U2AF2(2), XRN2(3)	9692495	110	48	110	47	69	5	3	16	17	0	0.496	1.000	1.000
354	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(5), ADCY2(5), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(2), ADCY8(8), ADK(1), AK2(1), AK5(2), ALLC(2), AMPD1(5), AMPD2(1), AMPD3(7), ATIC(1), ATP5F1(1), CANT1(3), DGUOK(1), ENPP3(4), ENTPD1(1), GART(4), GDA(3), GMPS(1), GUCY1A2(3), GUCY1A3(7), GUCY1B3(2), GUCY2C(8), GUCY2D(2), GUCY2F(3), NPR1(5), NPR2(2), PAPSS2(1), PDE1A(7), PDE4A(3), PDE4B(3), PDE4C(4), PDE4D(1), PDE5A(2), PDE6B(4), PDE6C(4), PDE6G(1), PDE7B(6), PDE8A(1), PFAS(2), PKLR(2), PKM2(1), POLD1(2), POLE(1), POLG(1), POLL(1), POLQ(5), POLR1B(1), POLR2A(4), POLR2B(3), POLR2E(1), POLR2F(1), POLR2J(1), POLR2L(1), POLRMT(1), PRPS1L1(4), RRM1(1)	11643402	167	48	167	91	110	15	7	20	15	0	0.280	1.000	1.000
355	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(3), AKR1D1(3), ARSD(1), ARSE(1), CARM1(3), CYP11B1(3), CYP11B2(6), CYP19A1(2), HEMK1(1), HSD11B1(3), HSD11B2(1), HSD17B12(1), HSD17B2(2), HSD17B3(2), HSD17B7(1), HSD3B2(3), LCMT1(1), METTL2B(2), PRMT3(2), PRMT8(1), SRD5A1(1), SRD5A2(1), STS(3), SULT1E1(3), SULT2A1(2), SULT2B1(1), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A7(4), UGT1A8(1), UGT2A1(5), UGT2A3(8), UGT2B10(5), UGT2B11(6), UGT2B15(5), UGT2B28(11), UGT2B4(12), UGT2B7(6)	4530366	121	47	119	52	82	9	9	7	13	1	0.0239	1.000	1.000
356	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(4), AGTR2(2), ATP8A1(4), AVPR1B(3), BDKRB2(3), C3AR1(3), CCKAR(4), CCKBR(5), CCR1(5), CCR2(8), CCR3(4), CCR4(3), CCR7(1), CCR8(2), CX3CR1(3), CXCR3(1), CXCR4(1), CXCR6(1), EDNRA(2), EDNRB(1), FPR1(5), FSHR(3), GALR1(2), GNB2L1(2), GPR77(1), GRPR(1), LHCGR(7), MC2R(1), MC3R(1), MC4R(1), MC5R(1), NMBR(2), NPY1R(5), NPY2R(3), NPY5R(6), NTSR2(1), OPRK1(3), OPRM1(1), OXTR(2), PPYR1(1), SSTR1(5), SSTR2(2), SSTR4(3), TACR1(1), TACR2(2), TACR3(4), TRHR(5), TSHR(1)	4763691	132	47	132	88	87	9	11	14	11	0	0.110	1.000	1.000
357	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(4), ASH2L(3), CARM1(3), CTCFL(6), DOT1L(1), EHMT1(1), EHMT2(1), EZH2(1), FBXO11(2), HCFC1(7), JMJD4(1), JMJD6(1), KDM6A(1), MLL(9), MLL2(9), MLL3(17), MLL4(7), MLL5(4), NSD1(3), OGT(6), PAXIP1(1), PPP1CB(1), PRDM2(2), PRDM9(11), PRMT1(1), PRMT8(1), SATB1(5), SETD1A(5), SETD2(4), SETD8(1), SETDB1(4), SETMAR(1), STK38(2), SUV420H1(1), SUZ12(1), WHSC1(1), WHSC1L1(1)	10735184	130	46	128	47	86	9	5	17	13	0	0.176	1.000	1.000
358	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(2), CCKBR(5), CCR2(8), CCR3(4), CELSR1(6), CELSR2(3), CELSR3(8), CHRM2(6), CHRM3(3), CXCR3(1), EDNRA(2), EMR2(2), EMR3(6), F2R(2), FSHR(3), GHRHR(1), GPR116(9), GPR133(2), GPR143(1), GPR55(1), GPR56(2), GPR61(3), GPR77(1), GPR84(2), GRM1(3), GRPR(1), HRH4(1), LGR6(2), LPHN2(5), LPHN3(7), OR2M4(1), OR8G2(6), P2RY13(2), PTGFR(6), SMO(1), SSTR2(2), TAAR5(3), TSHR(1)	6056273	124	46	123	80	76	15	3	23	7	0	0.469	1.000	1.000
359	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(6), ADH1C(8), ADH4(2), ADH5(1), ADH7(5), ADHFE1(3), AGK(3), AGPAT2(3), AGPAT4(3), AGPAT6(1), AKR1A1(1), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), CEL(2), DAK(2), DGAT1(1), DGKA(1), DGKB(5), DGKD(2), DGKE(4), DGKG(4), DGKH(2), DGKI(4), DGKQ(2), DGKZ(1), GK(1), GK2(2), GLB1(1), GPAM(1), LCT(6), LIPC(1), LIPF(3), LPL(1), MGLL(3), PNLIP(1), PNLIPRP1(2), PPAP2C(1)	5365936	99	46	97	43	63	6	6	14	10	0	0.107	1.000	1.000
360	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	INPP5A(1), INPP5B(1), INPPL1(4), IPMK(1), ITPK1(2), ITPKB(2), MIOX(2), OCRL(1), PI4KA(6), PI4KB(1), PIK3C3(2), PIK3CA(1), PIK3CB(7), PIK3CD(1), PIK3CG(7), PIP4K2B(1), PIP5K1A(2), PIP5K1B(6), PIP5K1C(2), PLCB1(13), PLCB2(4), PLCB4(13), PLCD3(3), PLCE1(11), PLCG2(6), PLCZ1(6), PTEN(4), SYNJ1(3), SYNJ2(2)	6730061	115	46	110	40	72	9	3	20	11	0	0.00876	1.000	1.000
361	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1B(1), ACVRL1(2), BUB1(2), CDKL1(1), CDKL2(1), CDS2(1), CLK1(2), CLK2(2), CSNK2A2(1), DGKA(1), DGKB(5), DGKD(2), DGKE(4), DGKG(4), DGKH(2), DGKQ(2), DGKZ(1), INPP5A(1), INPPL1(4), ITPKB(2), NEK1(1), NEK3(1), OCRL(1), PIK3C2A(3), PIK3C2B(5), PIK3C2G(13), PIK3CA(1), PIK3CB(7), PIK3CG(7), PIM2(2), PLCB1(13), PLCB2(4), PLCB4(13), PLCG2(6), PRKACA(1), PRKACG(2), PRKAR2B(1), PRKCA(1), PRKCD(1), PRKCG(4), PRKCH(1), PRKCQ(4), PRKCZ(2), PRKG1(1), RAF1(2), RPS6KA1(3), RPS6KA3(1), RPS6KB1(1), STK11(1)	10241318	144	46	139	76	94	7	2	20	21	0	0.507	1.000	1.000
362	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ABP1(5), ACMSD(5), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), AOC2(2), AOC3(2), AOX1(6), ASMT(2), CAT(2), CYP19A1(2), CYP1A1(3), CYP1A2(2), CYP2A13(3), CYP2A6(5), CYP2A7(2), CYP2B6(5), CYP2C18(5), CYP2C19(17), CYP2C8(8), CYP2C9(9), CYP2E1(1), CYP2F1(1), CYP2J2(1), CYP3A4(4), CYP3A5(3), CYP3A7(3), CYP4B1(7), CYP4F8(4), DDC(2), GCDH(2), HADHA(1), KYNU(2), MAOB(2), TDO2(3), TPH1(2), WARS(1), WARS2(2)	4987511	136	46	135	77	98	8	8	13	9	0	0.267	1.000	1.000
363	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(2), ACADL(2), ACADM(2), ACOX3(2), ACSL1(1), ACSL3(2), ACSL5(2), ACSL6(4), ADIPOQ(1), ANGPTL4(3), APOA5(1), AQP7(1), CD36(1), CPT1A(2), CPT1B(3), CPT2(1), CYP4A11(7), CYP4A22(5), CYP7A1(1), CYP8B1(3), FABP1(3), FABP2(2), GK(1), GK2(2), HMGCS2(3), LPL(1), ME1(3), MMP1(4), PCK1(4), PCK2(3), PPARA(2), PPARD(1), PPARG(3), RXRA(1), RXRB(2), SCD(2), SCP2(1), SLC27A1(1), SLC27A2(5), SLC27A5(4), SLC27A6(8), SORBS1(5), UBC(1)	5980718	108	45	107	60	77	8	3	7	13	0	0.459	1.000	1.000
364	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(17), COL4A2(5), COL4A3(6), COL4A4(20), COL4A5(13), COL4A6(10), F10(2), F11(3), F2(4), F2R(2), F5(7), F8(6), F9(4), FGA(8), FGG(2), KLKB1(6), PROS1(2), SERPINC1(1), SERPING1(3)	4041810	121	45	121	42	84	8	8	12	9	0	0.476	1.000	1.000
365	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS2(1), ADH1A(2), ADH1B(6), ADH1C(8), ADH4(2), ADH5(1), ADH7(5), ADHFE1(3), AKR1A1(1), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B2(1), ALDH7A1(2), ALDOB(2), BPGM(1), DLAT(1), DLD(1), ENO1(1), ENO2(2), ENO3(2), FBP2(1), G6PC(2), G6PC2(1), GALM(1), GAPDH(1), GAPDHS(1), GCK(3), HK1(1), HK2(1), HK3(2), LDHA(2), LDHAL6B(2), PDHA1(1), PDHA2(2), PDHB(1), PGAM2(1), PGK2(5), PKLR(2), PKM2(1)	5303907	79	44	76	42	51	7	8	6	7	0	0.253	1.000	1.000
366	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(2), ACADL(2), ACADM(2), ACADS(2), ACADSB(1), ACOX3(2), ACSL1(1), ACSL3(2), ACSL5(2), ACSL6(4), ADH1A(2), ADH1B(6), ADH1C(8), ADH4(2), ADH5(1), ADH7(5), ADHFE1(3), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), CPT1A(2), CPT1B(3), CPT2(1), CYP4A11(7), CYP4A22(5), DCI(1), GCDH(2), HADHA(1), HADHB(3), HSD17B4(1)	4480481	81	44	78	34	56	5	8	5	7	0	0.0836	1.000	1.000
367	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	APH1A(1), CREBBP(6), DLL1(1), DLL3(1), DLL4(3), DTX1(3), DTX2(1), DTX3(1), DTX3L(1), DTX4(1), DVL2(3), EP300(4), JAG1(2), JAG2(1), LFNG(3), MAML2(4), MAML3(2), MFNG(2), NCOR2(8), NCSTN(1), NOTCH1(1), NOTCH2(9), NOTCH3(6), NOTCH4(13), NUMB(2), NUMBL(1), RBPJ(1), RBPJL(1)	6270109	83	44	83	36	39	10	5	21	8	0	0.452	1.000	1.000
368	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(5), ADH1A(2), ADH1B(6), ADH1C(8), ADH4(2), ADH5(1), ADH7(5), ADHFE1(3), ALDH3A1(1), ALDH3B2(1), AOC2(2), AOC3(2), AOX1(6), CARM1(3), COMT(1), DBH(4), DDC(2), FAH(1), GOT2(3), HEMK1(1), HGD(2), HPD(1), LCMT1(1), MAOB(2), METTL2B(2), MYST3(4), MYST4(1), PRMT3(2), PRMT8(1), TAT(5), TH(1), TPO(8), TYRP1(2)	5406646	91	43	89	47	63	6	4	10	8	0	0.337	1.000	1.000
369	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(7), ACSL1(1), ACSL3(2), ACSL5(2), ACSL6(4), ADIPOQ(1), ADIPOR1(3), AKT2(4), AKT3(2), CAMKK1(1), CAMKK2(3), CD36(1), CPT1A(2), CPT1B(3), CPT2(1), G6PC(2), G6PC2(1), IRS1(3), IRS2(1), IRS4(2), JAK1(1), JAK2(1), JAK3(2), LEPR(7), MAPK10(2), NFKB1(3), NFKB2(2), PCK1(4), PCK2(3), PPARA(2), PPARGC1A(5), PRKAA2(5), PRKAB2(1), PRKAG1(1), PRKAG2(1), PRKAG3(5), PRKCQ(4), PTPN11(1), RELA(2), RXRA(1), RXRB(2), SLC2A1(1), SLC2A4(1), SOCS3(1), STK11(1), TNFRSF1A(1), TNFRSF1B(2), TYK2(3)	7569072	111	43	110	52	72	10	5	13	11	0	0.180	1.000	1.000
370	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), ACTG2(3), ACTR2(2), ACTR3(2), FLNA(2), FLNC(10), FSCN1(1), FSCN2(1), FSCN3(2), GDI1(1), GDI2(1), LIMK1(1), MYH2(26), MYLK(11), MYLK2(2), PAK1(1), PAK6(2), PAK7(15), ROCK2(2), VASP(1), WASF1(1), WASL(2)	4335752	90	43	86	33	59	15	2	8	6	0	0.00542	1.000	1.000
371	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	AGTR1(4), AGTR2(2), CMA1(1), COL4A1(17), COL4A2(5), COL4A3(6), COL4A4(20), COL4A5(13), COL4A6(10), REN(1)	2297298	79	42	79	27	58	6	3	7	5	0	0.755	1.000	1.000
372	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(6), ADH1C(8), ADH4(2), ADH7(5), ADHFE1(3), AKR1A1(1), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B2(1), ALDOB(2), BPGM(1), DLAT(1), DLD(1), ENO1(1), ENO2(2), ENO3(2), FBP2(1), G6PC(2), GAPDH(1), GCK(3), HK1(1), HK2(1), HK3(2), LDHA(2), PDHA1(1), PDHA2(2), PDHB(1), PKLR(2), PKM2(1)	4449162	68	42	65	32	46	6	6	5	5	0	0.126	1.000	1.000
373	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(6), ADH1C(8), ADH4(2), ADH7(5), ADHFE1(3), AGPAT2(3), AGPAT4(3), AKR1A1(1), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), CEL(2), DGAT1(1), DGKA(1), DGKB(5), DGKD(2), DGKE(4), DGKG(4), DGKH(2), DGKQ(2), DGKZ(1), GK(1), GLB1(1), LCT(6), LIPC(1), LIPF(3), LPL(1), PNLIP(1), PNLIPRP1(2), PPAP2C(1)	4404004	84	42	82	35	56	3	5	12	8	0	0.0849	1.000	1.000
374	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(6), ADH1C(8), ADH4(2), ADH7(5), ADHFE1(3), AKR1A1(1), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B2(1), ALDOB(2), BPGM(1), DLAT(1), DLD(1), ENO1(1), ENO2(2), ENO3(2), FBP2(1), G6PC(2), GAPDH(1), GCK(3), HK1(1), HK2(1), HK3(2), LDHA(2), PDHA1(1), PDHA2(2), PDHB(1), PKLR(2), PKM2(1)	4449162	68	42	65	32	46	6	6	5	5	0	0.126	1.000	1.000
375	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(1), BLVRA(1), COX10(3), CP(2), EPRS(2), FECH(3), FTH1(2), FTMT(1), HMOX2(1), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A7(4), UGT1A8(1), UGT2A1(5), UGT2A3(8), UGT2B10(5), UGT2B11(6), UGT2B15(5), UGT2B28(11), UGT2B4(12), UGT2B7(6)	3829159	84	42	83	35	55	6	7	3	12	1	0.0804	1.000	1.000
376	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(2), CALM1(1), CAMK1G(3), CAMK4(1), CREBBP(6), CSNK1A1(1), ELSPBP1(1), F2(4), FGF2(2), FKBP1A(1), GATA4(1), HAND2(2), HRAS(1), IGF1(2), LIF(2), MAP2K1(4), MAPK1(3), MAPK3(1), MEF2C(1), MYH2(26), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), NKX2-5(1), NPPA(1), PIK3CA(1), PRKACG(2), PRKAR2B(1), RAF1(2), RPS6KB1(1), SYT1(4)	4630879	89	42	87	44	59	10	6	7	7	0	0.357	1.000	1.000
377	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(2), BAX(2), BTK(4), CAD(3), CASP3(1), CASP8(2), CASP8AP2(3), CDK2AP1(1), CSNK1A1(1), DAXX(3), DIABLO(1), EGFR(6), EPHB2(4), FAF1(2), IL1A(1), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K5(3), MAPK1(3), MAPK10(2), MAPK8IP2(2), MAPK8IP3(3), MET(6), NFAT5(2), NFKB1(3), NFKB2(2), NFKBIL2(2), NR0B2(1), PTPN13(6), RALBP1(2), RIPK1(1), SMPD1(1), TP53(13), TPX2(2), TUFM(2)	6618712	95	42	93	32	51	5	8	14	17	0	0.0418	1.000	1.000
378	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ALPI(2), ALPL(1), ALPP(1), ALPPL2(4), CYP19A1(2), CYP1A1(3), CYP1A2(2), CYP2A13(3), CYP2A6(5), CYP2A7(2), CYP2B6(5), CYP2C18(5), CYP2C19(17), CYP2C8(8), CYP2C9(9), CYP2E1(1), CYP2F1(1), CYP2J2(1), CYP3A4(4), CYP3A5(3), CYP3A7(3), CYP4B1(7), CYP4F8(4), PON1(4)	2647495	98	41	97	59	74	5	5	6	8	0	0.193	1.000	1.000
379	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT2(4), AKT3(2), BRAF(3), DAG1(4), DRD2(2), EGFR(6), EPHB2(4), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(2), KCNJ3(4), KCNJ5(2), KCNJ9(2), MAPK1(3), PI3(1), PIK3CB(7), PITX2(2), PLCB1(13), PLCB2(4), PLCB4(13), RAF1(2), SOS1(1), SOS2(2), TERF2IP(1)	5337198	98	41	94	37	62	4	7	13	12	0	0.0232	1.000	1.000
380	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	CAD(3), CANT1(3), CTPS(1), DCTD(1), DHODH(1), DPYD(15), DPYS(2), ENTPD1(1), ENTPD3(2), ENTPD4(1), ENTPD6(1), ENTPD8(1), NME6(1), NME7(2), NT5C1A(1), NT5C1B(4), NT5C2(1), POLA1(1), POLA2(3), POLD1(2), POLD3(1), POLE(1), POLE2(1), POLR1A(3), POLR1B(1), POLR2A(4), POLR2B(3), POLR2E(1), POLR2F(1), POLR2J(1), POLR2L(1), POLR3A(1), POLR3B(2), PRIM2(3), RRM1(1), TXNRD1(1), UCK1(1), UMPS(1), UPB1(2)	7382847	77	40	76	35	48	4	3	16	6	0	0.275	1.000	1.000
381	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT2(4), AKT3(2), BCR(2), BTK(4), CD19(1), CDKN2A(12), ITPR1(4), ITPR2(8), ITPR3(2), LYN(1), NR0B2(1), PDK1(1), PIK3CA(1), PITX2(2), PLCG2(6), PPP1R13B(2), PREX1(1), PTEN(4), PTPRC(3), RPS6KA1(3), RPS6KA3(1), RPS6KB1(1), SAG(2), SYK(3), TEC(2), VAV1(3)	5019179	76	40	71	32	39	5	3	8	21	0	0.0615	1.000	1.000
382	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(2), F11(3), F13B(6), F2(4), F5(7), F7(3), F8(6), F9(4), FGA(8), FGG(2), LPA(14), PLAT(3), PLG(8), SERPINB2(6), SERPINF2(3), VWF(9)	3191410	88	39	88	40	65	4	9	1	9	0	0.273	1.000	1.000
383	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(3), ALOX12(1), ALOX12B(1), ALOX15(1), ALOX15B(1), ALOX5(2), CYP2B6(5), CYP2C18(5), CYP2C19(17), CYP2C8(8), CYP2C9(9), CYP2E1(1), CYP2J2(1), CYP2U1(1), CYP4A11(7), CYP4A22(5), CYP4F2(2), CYP4F3(6), EPHX2(1), GGT1(1), GPX5(3), GPX6(6), LTA4H(1), PLA2G1B(1), PLA2G2D(1), PLA2G2F(2), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), PTGIS(5), PTGS1(3), PTGS2(3), TBXAS1(2)	3516660	115	39	113	86	87	7	3	9	9	0	0.797	1.000	1.000
384	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(3), ADCY4(1), ADCY6(2), ADCY8(8), CACNA1A(7), CACNA1B(4), GNAS(6), GNAT3(1), GNB3(2), GRM4(3), ITPR3(2), KCNB1(6), PDE1A(7), PLCB2(4), PRKACA(1), PRKACG(2), PRKX(1), SCNN1A(2), SCNN1G(2), TAS1R1(3), TAS1R2(6), TAS2R1(3), TAS2R10(2), TAS2R16(1), TAS2R38(3), TAS2R39(1), TAS2R41(2), TAS2R42(1), TAS2R46(1), TAS2R50(1), TAS2R60(3), TAS2R9(1), TRPM5(4)	5158744	96	39	96	87	60	8	6	9	13	0	0.941	1.000	1.000
385	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(2), BDKRB2(3), CALM1(1), CHRNA1(1), FLT1(9), FLT4(5), KDR(10), NOS3(2), PDE2A(4), PDE3A(8), PDE3B(1), PRKACG(2), PRKAR2B(1), PRKG1(1), PRKG2(3), RYR2(20), SLC7A1(1), SYT1(4)	3713975	78	39	75	52	55	8	2	9	4	0	0.757	1.000	1.000
386	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A7(4), UGT1A8(1), UGT2A1(5), UGT2A3(8), UGT2B10(5), UGT2B11(6), UGT2B15(5), UGT2B28(11), UGT2B4(12), UGT2B7(6)	2470630	68	38	67	31	46	5	5	2	9	1	0.190	1.000	1.000
387	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP4(1), BMP5(8), BMP6(2), BMP7(1), BMP8A(1), CSNK1A1(1), CSNK1A1L(1), CSNK1G3(1), GLI2(9), GLI3(3), HHIP(5), LRP2(25), PRKACA(1), PRKACG(2), PRKX(1), PTCH1(1), PTCH2(4), SHH(1), SMO(1), STK36(4), WNT10A(2), WNT11(1), WNT3(1), WNT3A(4), WNT4(1), WNT5A(1), WNT5B(1), WNT7A(2), WNT8B(3), WNT9B(1)	5494167	91	38	91	44	63	5	5	12	6	0	0.261	1.000	1.000
388	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	BRAF(3), DAXX(3), FOS(1), HRAS(1), MAP2K1(4), MAP2K2(1), MAP2K3(2), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K11(3), MAP3K13(1), MAP3K14(2), MAP3K4(3), MAP3K5(3), MAP3K6(1), MAP3K7(1), MAP3K9(6), MAP4K1(2), MAP4K2(1), MAP4K3(3), MAP4K4(3), MAPK1(3), MAPK10(2), MAPK3(1), MAPK4(4), MAPK6(2), MAPK7(2), MAPKAPK2(2), MAPKAPK3(1), MEF2A(2), MEF2B(1), MEF2C(1), MEF2D(2), MYC(2), NFKB1(3), PAK1(1), RAC1(3), RAF1(2), RELA(2), RIPK1(1), RPS6KA1(3), RPS6KA3(1), RPS6KB1(1), RPS6KB2(2), STAT1(2), TGFB1(1), TGFB3(1)	8617391	95	38	94	44	59	8	3	15	10	0	0.452	1.000	1.000
389	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT2(4), AKT3(2), BCL2(1), BCR(2), BLNK(2), BTK(4), CD19(1), CD22(4), CR2(7), DAG1(4), INPP5D(7), ITPR1(4), ITPR2(8), ITPR3(2), LYN(1), MAP4K1(2), MAPK1(3), MAPK3(1), NFATC1(2), NFATC2(1), NR0B2(1), PDK1(1), PIK3CA(1), PIK3CD(1), PLCG2(6), PPP1R13B(2), PTPRC(3), RAF1(2), SOS1(1), SOS2(2), SYK(3), VAV1(3)	6736858	88	38	87	44	53	8	7	8	12	0	0.255	1.000	1.000
390	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(5), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH4A1(2), AOC2(2), AOC3(2), ASL(3), CKM(1), CKMT2(1), CPS1(4), DAO(1), GAMT(1), GATM(1), GOT2(3), MAOB(2), NOS1(11), NOS3(2), OAT(1), OTC(1), P4HA1(2), P4HA3(2), PYCR1(1)	3996437	58	37	57	42	35	9	2	8	4	0	0.893	1.000	1.000
391	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP5A(1), INPPL1(4), ITPKB(2), MIOX(2), OCRL(1), PIK3C2A(3), PIK3C2B(5), PIK3C2G(13), PIK3CA(1), PIK3CB(7), PIK3CG(7), PLCB1(13), PLCB2(4), PLCB4(13), PLCG2(6)	4065593	82	37	77	32	53	6	1	11	11	0	0.0564	1.000	1.000
392	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(2), BLNK(2), FOS(1), HRAS(1), LYN(1), MAP2K1(4), MAP3K1(1), MAPK1(3), MAPK3(1), MAPK8IP3(3), PAPPA(20), RAC1(3), RPS6KA1(3), RPS6KA3(1), SOS1(1), SYK(3), VAV1(3), VAV2(2), VAV3(4)	2903546	59	37	58	31	44	1	1	5	8	0	0.515	1.000	1.000
393	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(4), ABP1(5), ACADL(2), ACADM(2), ACADSB(1), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), AOC2(2), AOC3(2), CNDP1(1), DPYD(15), DPYS(2), GAD1(3), GAD2(1), HADHA(1), UPB1(2)	2649814	53	36	52	29	38	1	5	7	2	0	0.527	1.000	1.000
394	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1R(3), C1S(1), C2(3), C3(11), C5(3), C6(14), C7(11), C8A(9), C8B(9), C9(7), MASP1(4)	1870903	75	36	71	32	52	5	3	6	9	0	0.116	1.000	1.000
395	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(2), ADH1A(2), ADH1B(6), ADH1C(8), ADH4(2), ADH5(1), ADH7(5), ADHFE1(3), AKR1B10(3), AKR1C4(3), AKR1D1(3), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), BAAT(4), CEL(2), CYP7A1(1), HADHB(3), HSD3B7(2), RDH13(1), SLC27A5(4), SOAT2(2), SRD5A1(1), SRD5A2(1)	2893514	67	36	65	31	44	5	10	4	4	0	0.154	1.000	1.000
396	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(3), ALOX15(1), ALOX5(2), CYP1A2(2), CYP2C18(5), CYP2C19(17), CYP2C8(8), CYP2C9(9), CYP2E1(1), CYP2J2(1), CYP3A4(4), CYP3A43(4), CYP3A5(3), CYP3A7(3), HSD3B7(2), PLA2G1B(1), PLA2G2D(1), PLA2G2F(2), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), RDH13(1)	2173287	80	36	79	53	62	2	4	7	5	0	0.584	1.000	1.000
397	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(7), ACACB(7), ACOT12(4), ACSS2(1), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), DLAT(1), DLD(1), GRHPR(1), LDHA(2), LDHAL6B(2), MDH2(1), ME1(3), ME3(1), PC(3), PCK1(4), PCK2(3), PDHA1(1), PDHA2(2), PDHB(1), PKLR(2), PKM2(1)	4269599	56	36	55	32	29	6	8	9	4	0	0.694	1.000	1.000
398	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(8), ATP6V0D2(3), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(3), ATP6V1G3(1), ATP6V1H(1), CASP3(1), EGFR(6), GIT1(2), IGSF5(3), JAM2(2), LYN(1), MAP2K4(1), MAP3K14(2), MAPK10(2), MET(6), NFKB1(3), NFKB2(2), NOD1(2), PAK1(1), PLCG2(6), PTPN11(1), PTPRZ1(5), RAC1(3), RELA(2), TJP1(3)	6414258	77	36	76	39	46	6	7	10	8	0	0.386	1.000	1.000
399	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(5), ADH1A(2), ADH1B(6), ADH1C(8), ADH4(2), ADH7(5), ADHFE1(3), ALDH3A1(1), ALDH3B2(1), AOC2(2), AOC3(2), AOX1(6), COMT(1), DBH(4), DDC(2), FAH(1), GOT2(3), HGD(2), HPD(1), MAOB(2), TAT(5), TH(1), TPO(8)	2875474	73	36	71	37	53	6	4	4	6	0	0.162	1.000	1.000
400	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CD74(2), CD8A(1), CD8B(2), CIITA(5), CTSS(2), HLA-A(2), HLA-B(1), HLA-C(1), HLA-DMA(2), HLA-DOA(1), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(2), HLA-DRA(3), HLA-DRB5(1), HLA-E(1), HLA-F(4), HSPA5(2), IFNA16(1), IFNA2(1), IFNA21(1), IFNA4(1), IFNA8(1), KIR2DL1(2), KIR2DS4(3), KIR3DL1(1), KIR3DL2(2), KIR3DL3(1), KLRC1(1), KLRC3(4), LGMN(2), NFYA(1), NFYB(1), PSME2(1), RFX5(1), TAP1(1), TAP2(1)	4187498	63	35	63	39	39	6	1	9	8	0	0.715	1.000	1.000
401	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(3), CD3D(1), CTLA4(2), DAG1(4), EPHB2(4), FBXW7(1), GRAP2(2), ITK(3), ITPKB(2), LCK(4), LCP2(4), MAPK1(3), NCK1(1), NFAT5(2), NFKB1(3), NFKB2(2), NFKBIL2(2), PAK1(1), PAK6(2), PAK7(15), PTPRC(3), RAF1(2), RASGRP1(2), RASGRP2(1), RASGRP3(4), RASGRP4(1), SOS1(1), SOS2(2), VAV1(3), ZAP70(3)	5054164	83	35	82	38	47	9	4	11	12	0	0.253	1.000	1.000
402	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGTR2(2), CALM1(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CDK5(2), F2(4), FYN(2), GNA11(2), HRAS(1), JAK2(1), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), MAPT(3), MYLK(11), PRKCA(1), RAF1(2), SOS1(1), STAT1(2), SYT1(4)	3777088	52	34	50	35	32	4	2	8	6	0	0.879	1.000	1.000
403	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPAT2(3), AGPAT4(3), AGPS(1), CDS2(1), CHAT(3), CPT1B(3), DGKA(1), DGKB(5), DGKD(2), DGKE(4), DGKG(4), DGKH(2), DGKQ(2), DGKZ(1), ETNK1(1), GPD1(1), GPD2(1), PAFAH1B1(1), PAFAH2(1), PCYT1B(2), PEMT(1), PLA2G1B(1), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), PLCB2(4), PLCG2(6), PPAP2C(1)	4555382	66	34	65	40	44	3	0	10	9	0	0.577	1.000	1.000
404	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B10(3), G6PC(2), G6PC2(1), GAA(4), GALK1(1), GALK2(1), GCK(3), GLB1(1), HK1(1), HK2(1), HK3(2), HSD3B7(2), LALBA(1), LCT(6), MGAM(31), RDH13(1)	3513302	61	34	60	36	48	5	2	3	3	0	0.324	1.000	1.000
405	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	CD36(1), CPT1B(3), CREBBP(6), EP300(4), FABP1(3), HSD17B4(1), LPL(1), MAPK1(3), MAPK3(1), ME1(3), MYC(2), NCOA1(2), NCOR1(1), NCOR2(8), NR0B2(1), NR2F1(2), NRIP1(1), PIK3CA(1), PPARA(2), PRKACG(2), PRKAR2B(1), PRKCA(1), PTGS2(3), RB1(3), RELA(2), RXRA(1), STAT5B(1)	5779170	60	34	60	26	37	6	3	8	6	0	0.349	1.000	1.000
406	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT2(4), AKT3(2), BCR(2), BLNK(2), BTK(4), CD19(1), DAG1(4), EPHB2(4), ITPKB(2), LYN(1), MAP2K1(4), MAP2K2(1), MAPK1(3), NFAT5(2), NFKB1(3), NFKB2(2), NFKBIL2(2), PI3(1), PIK3CA(1), PIK3CD(1), PLCG2(6), PPP1R13B(2), RAF1(2), SOS1(1), SOS2(2), SYK(3), VAV1(3)	4817077	65	34	64	34	35	3	4	12	11	0	0.566	1.000	1.000
407	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(4), AXIN1(2), CCND2(1), CTNNB1(1), DVL2(3), FZD1(1), FZD2(1), FZD5(1), FZD7(1), FZD8(1), FZD9(1), LDLR(2), MAPK10(2), MYC(2), PAFAH1B1(1), PPP2R5C(3), PPP2R5E(1), PRKCA(1), PRKCD(1), PRKCG(4), PRKCH(1), PRKCI(1), PRKCQ(4), PRKCZ(2), RAC1(3), WNT10A(2), WNT11(1), WNT3(1), WNT4(1), WNT5A(1), WNT5B(1), WNT7A(2)	5431840	54	34	54	33	32	5	1	9	7	0	0.718	1.000	1.000
408	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	FBP2(1), G6PC(2), GAA(4), GALK1(1), GALK2(1), GANAB(1), GCK(3), GLB1(1), HK1(1), HK2(1), HK3(2), LALBA(1), LCT(6), MGAM(31)	2958151	56	33	55	30	43	5	2	3	3	0	0.218	1.000	1.000
409	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(4), ABP1(5), ACADM(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), AOC2(2), AOC3(2), CNDP1(1), DPYD(15), DPYS(2), GAD1(3), GAD2(1), HADHA(1), UPB1(2)	2466121	48	33	47	30	33	2	5	6	2	0	0.745	1.000	1.000
410	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(1), ADRB1(1), ADRB2(1), CHRM2(6), CHRM3(3), CHRM4(2), DRD1(3), DRD2(2), DRD3(3), DRD5(3), HRH1(3), HRH2(2), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(1), HTR1F(2), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(1), HTR5A(7), HTR7(2)	2294191	55	33	54	52	36	2	2	6	9	0	0.700	1.000	1.000
411	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(7), ADH5(1), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), DLAT(1), DLD(1), GRHPR(1), LDHA(2), MDH2(1), ME1(3), ME3(1), PC(3), PCK1(4), PDHA1(1), PDHA2(2), PDHB(1), PKLR(2), PKM2(1)	3375888	42	33	41	28	26	2	6	5	3	0	0.862	1.000	1.000
412	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(10), CDR1(2), DGKI(4), IL6ST(2), PIGK(3), RPL10(2), RPL11(1), RPL18(2), RPL27(1), RPL3(1), RPL39(1), RPL4(2), RPL7(1), RPS13(1), RPS15(1), RPS2(1), RPS20(1), RPS6(1), RPS6KA1(3), RPS6KA3(1), RPS6KA6(4), RPS6KB1(1), RPS6KB2(2), SLC36A2(1), TBC1D10C(1), TSPAN9(1), UBC(1)	4717605	52	33	51	27	32	4	2	9	5	0	0.488	1.000	1.000
413	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(4), CALM1(1), FCER1A(4), FOS(1), HRAS(1), LYN(1), MAP2K1(4), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAPK1(3), MAPK3(1), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), PIK3CA(1), PLA2G4A(2), RAF1(2), SOS1(1), SYK(3), SYT1(4), VAV1(3)	3908366	50	32	49	30	31	2	4	5	8	0	0.885	1.000	1.000
414	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(5), AGXT(1), AGXT2(7), AOC2(2), AOC3(2), CBS(4), CHDH(1), CPT1B(3), DAO(1), DLD(1), DMGDH(2), GAMT(1), GATM(1), GCAT(1), GLDC(1), MAOB(2), PEMT(1), PLCB2(4), PLCG2(6), PSPH(1), SARDH(4), SARS(1), SHMT2(1)	3827023	53	32	52	42	37	2	2	4	8	0	0.901	1.000	1.000
415	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(1), ABP1(5), ACMSD(5), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), AOC2(2), AOC3(2), AOX1(6), ASMT(2), CARM1(3), CAT(2), CYP1A1(3), CYP1A2(2), DDC(2), GCDH(2), HADHA(1), HEMK1(1), HSD17B4(1), INMT(1), KYNU(2), LCMT1(1), LNX1(4), MAOB(2), METTL2B(2), NFX1(2), OGDH(2), OGDHL(9), PRMT3(2), PRMT8(1), TDO2(3), TPH1(2), TPH2(1), WARS(1), WARS2(2)	5508920	85	32	85	36	53	7	4	14	7	0	0.121	1.000	1.000
416	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(1), AGPAT2(3), AGPAT4(3), AGPAT6(1), CDS2(1), CHAT(3), CHPT1(1), DGKA(1), DGKB(5), DGKD(2), DGKE(4), DGKG(4), DGKH(2), DGKI(4), DGKQ(2), DGKZ(1), ETNK1(1), GPAM(1), GPD1(1), GPD2(1), MYST3(4), MYST4(1), PCYT1B(2), PEMT(1), PLA2G1B(1), PLA2G2D(1), PLA2G2F(2), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), PLD1(2), PLD2(3), PPAP2C(1)	5950831	70	32	70	46	42	4	2	12	10	0	0.883	1.000	1.000
417	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(3), CANT1(3), CTPS(1), DCTD(1), DHODH(1), DPYD(15), DPYS(2), ENTPD1(1), POLD1(2), POLE(1), POLG(1), POLL(1), POLQ(5), POLR1B(1), POLR2A(4), POLR2B(3), POLR2E(1), POLR2F(1), POLR2J(1), POLR2L(1), POLRMT(1), RRM1(1), TXNRD1(1), UCK1(1), UMPS(1), UPB1(2)	5227756	56	32	55	26	34	6	3	9	4	0	0.286	1.000	1.000
418	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CDK5(2), CHN1(2), LIMK1(1), MAP3K1(1), MYL2(3), MYLK(11), NCF2(2), PAK1(1), PDGFRA(7), PIK3CA(1), PLD1(2), RAC1(3), RALBP1(2), RPS6KB1(1), TRIO(4), VAV1(3), WASF1(1)	3187615	47	32	45	29	29	3	2	8	5	0	0.832	1.000	1.000
419	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(4), EPHB2(4), F2(4), F2RL1(6), F2RL2(1), F2RL3(1), MAPK1(3), MAPK7(2), PLD1(2), PLD2(3), PTK2(3), RAF1(2), RASAL1(6), TEC(2), VAV1(3)	2490871	46	32	46	28	20	7	1	11	7	0	0.745	1.000	1.000
420	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT2(4), AKT3(2), ARHGEF11(3), BCL2(1), LPA(14), MAP2K4(1), MAP3K1(1), MAP3K5(3), NFKB1(3), NFKB2(2), NFKBIL2(2), PDK1(1), PHKA2(4), PI3(1), PIK3CB(7), PLD1(2), PLD2(3), PTK2(3), ROCK2(2), SRF(1)	4466232	60	32	59	26	31	5	3	12	9	0	0.402	1.000	1.000
421	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(1), CD3D(1), CD3G(1), FOS(1), FYN(2), HRAS(1), LCK(4), MAP2K1(4), MAP2K4(1), MAP3K1(1), MAPK3(1), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), NFKB1(3), PIK3CA(1), PRKCA(1), RAC1(3), RAF1(2), RASA1(3), RELA(2), SOS1(1), SYT1(4), VAV1(3), ZAP70(3)	4343990	55	32	54	29	33	6	3	8	5	0	0.758	1.000	1.000
422	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(3), AKR1D1(3), ARSD(1), ARSE(1), CYP11B1(3), CYP11B2(6), HSD11B1(3), HSD11B2(1), HSD17B2(2), HSD17B3(2), HSD3B2(3), SRD5A1(1), SRD5A2(1), STS(3), SULT1E1(3), SULT2A1(2), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A7(4), UGT1A8(1), UGT2B15(5), UGT2B4(12)	2473460	65	31	64	36	46	6	5	1	6	1	0.302	1.000	1.000
423	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(2), DLAT(1), DLD(1), ENO1(1), ENO2(2), ENO3(2), FBP2(1), G6PC(2), GAPDH(1), GAPDHS(1), GCK(3), GOT2(3), HK1(1), HK2(1), HK3(2), LDHA(2), LDHAL6B(2), MDH2(1), PC(3), PCK1(4), PDHA1(1), PDHA2(2), PDHB(1), PDHX(1), PGAM2(1), PGK2(5), PKLR(2), PKM2(1)	3877936	50	31	49	32	29	6	5	3	7	0	0.566	1.000	1.000
424	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(3), ATP4A(6), ATP4B(1), ATP5F1(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(8), ATP6V0D2(3), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(3), ATP6V1G3(1), ATP6V1H(1), COX10(3), COX4I2(4), COX5B(1), COX6A1(1), LHPP(1), NDUFA10(1), NDUFA13(4), NDUFA6(1), NDUFB2(1), NDUFB5(1), NDUFS3(1), NDUFS4(1), NDUFS6(1), SDHC(1), UQCRC2(1)	5112569	56	31	56	23	28	8	6	7	7	0	0.143	1.000	1.000
425	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(2), AARS2(2), ABAT(4), ACY3(1), ADSSL1(1), AGXT(1), AGXT2(7), ASL(3), ASNS(1), ASPA(3), ASRGL1(1), ASS1(2), CAD(3), CRAT(2), DARS(4), DARS2(1), DLAT(1), DLD(1), GAD1(3), GAD2(1), GOT2(3), NARS2(1), PC(3), PDHA1(1), PDHA2(2), PDHB(1)	3458646	55	31	53	23	39	5	5	3	3	0	0.0985	1.000	1.000
426	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(5), AGXT(1), AGXT2(7), AKR1B10(3), AOC2(2), AOC3(2), CBS(4), CHDH(1), DAO(1), DLD(1), DMGDH(2), GAMT(1), GATM(1), GCAT(1), GLDC(1), HSD3B7(2), MAOB(2), PEMT(1), PHGDH(3), PSPH(1), RDH13(1), SARDH(4), SARS(1), SHMT2(1), TARS2(2)	3890357	51	31	51	42	34	2	3	5	7	0	0.956	1.000	1.000
427	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(4), ACAA1(2), ACADM(2), ACADS(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), ALDH7A1(2), AOX1(6), AUH(1), BCAT1(1), BCKDHA(1), DLD(1), HADHA(1), HADHB(3), HIBADH(2), HMGCL(1), HMGCS2(3), HSD17B4(1), MCCC1(2), MCCC2(1), MUT(1), OXCT1(1), PCCB(1)	3937087	46	31	46	21	25	6	6	6	3	0	0.423	1.000	1.000
428	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), GRIN1(2), GRIN2A(15), GRIN2B(11), GRIN2C(1), GRIN2D(3), NOS1(11), PRKACG(2), PRKAR2B(1), PRKCA(1), SYT1(4)	2318534	52	31	50	47	37	7	0	5	3	0	0.959	1.000	1.000
429	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(4), BMPR1B(2), CCND2(1), CDK4(1), DMC1(3), EGR1(2), ESR2(3), FSHR(3), GJA4(2), INHA(1), LHCGR(7), MSH5(2), NCOR1(1), NR5A1(1), NRIP1(1), PGR(3), PRLR(5), PTGER2(1), SMPD1(1)	3173163	44	31	43	33	33	2	0	5	4	0	0.961	1.000	1.000
430	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(2), ACADL(2), ACADM(2), ACADS(2), ACADSB(1), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), AOX1(6), BCAT1(1), BCKDHA(1), HADHA(1), HADHB(3), HIBADH(2), HMGCL(1), MCCC1(2), MCCC2(1), MUT(1), OXCT1(1), PCCB(1)	3296518	41	31	41	18	24	4	6	5	2	0	0.379	1.000	1.000
431	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(15), GABBR1(1), GPRC5A(3), GRM1(3), GRM2(2), GRM3(13), GRM4(3), GRM5(3), GRM7(10), GRM8(4)	1904706	57	30	56	38	39	3	6	6	3	0	0.369	1.000	1.000
432	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(5), ALDH3A1(1), ALDH3B2(1), AOC2(2), AOC3(2), DDC(2), EPX(2), GOT2(3), HPD(1), LPO(2), MAOB(2), MPO(1), MYST3(4), MYST4(1), PRDX6(2), TAT(5), TPO(8)	3117884	44	30	44	31	29	5	3	2	5	0	0.802	1.000	1.000
433	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(2), ACTN1(1), ACTN2(3), ACTN3(2), BCAR1(1), BCR(2), CAPN1(1), FYN(2), HRAS(1), ITGA1(4), ITGB1(1), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), PTK2(3), RAF1(2), RAP1A(1), SOS1(1), TLN1(4), VCL(3), ZYX(1)	4254700	44	30	44	24	23	2	4	7	8	0	0.590	1.000	1.000
434	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(2), DOCK1(5), FOS(1), HGF(7), HRAS(1), ITGA1(4), ITGB1(1), MAP2K1(4), MAP2K2(1), MAP4K1(2), MAPK1(3), MAPK3(1), MET(6), PAK1(1), PIK3CA(1), PTEN(4), PTK2(3), PTPN11(1), RAF1(2), RAP1A(1), RAP1B(1), RASA1(3), SOS1(1)	3985619	56	30	56	25	31	4	2	7	12	0	0.534	1.000	1.000
435	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGTR1(4), CALM1(1), EGFR(6), GNAQ(1), HRAS(1), MAP2K1(4), MAP2K2(1), MAP2K4(1), MAP3K1(1), MAPK1(3), MAPK3(1), MEF2A(2), MEF2B(1), MEF2C(1), MEF2D(2), PAK1(1), PRKCA(1), PTK2(3), RAC1(3), RAF1(2), SOS1(1), SYT1(4)	3043906	45	29	44	21	30	1	3	3	8	0	0.525	1.000	1.000
436	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(1), CXCL12(1), CXCR4(1), GNAQ(1), HRAS(1), MAP2K1(4), MAPK1(3), MAPK3(1), NFKB1(3), PIK3C2G(13), PIK3CA(1), PRKCA(1), PTK2(3), RAF1(2), RELA(2)	2501207	38	29	38	23	22	3	0	6	7	0	0.812	1.000	1.000
437	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(1), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), CYP2C19(17), CYP2C9(9), DHRS2(2), DHRS3(1), DHRSX(1), HADHA(1), MYST3(4), MYST4(1)	2827270	45	29	44	31	27	3	5	4	6	0	0.880	1.000	1.000
438	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(6), ESR1(1), ESR2(3), HNF4A(1), NR1D2(3), NR1H2(1), NR1I3(1), NR2E1(2), NR2F1(2), NR2F2(1), NR3C1(2), NR4A2(1), NR5A1(1), NR5A2(3), PGR(3), PPARA(2), PPARD(1), PPARG(3), RARB(1), RORA(1), RORC(1), RXRA(1), RXRB(2), THRA(1), THRB(4)	3792976	48	29	48	33	35	6	0	3	4	0	0.832	1.000	1.000
439	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(7), CALCR(4), CALCRL(4), CD97(1), CRHR1(2), ELTD1(8), EMR1(2), EMR2(2), GHRHR(1), GLP1R(3), GLP2R(4), GPR64(2), LPHN1(1), LPHN2(5), LPHN3(7), SCTR(1), VIPR1(1), VIPR2(2)	2400308	57	28	55	32	38	3	4	4	8	0	0.267	1.000	1.000
440	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(5), ACY3(1), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B2(1), ALDH7A1(2), AOC2(2), AOC3(2), ASPA(3), CARM1(3), CNDP1(1), DDC(2), HAL(3), HARS(3), HDC(5), HEMK1(1), LCMT1(1), MAOB(2), METTL2B(2), PRMT3(2), PRMT8(1), UROC1(2)	3595638	50	28	50	34	30	4	5	5	6	0	0.779	1.000	1.000
441	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(1), ARSE(1), CERK(1), GAL3ST1(1), GBA(1), GLB1(1), LCT(6), NEU2(2), NEU3(1), NEU4(4), PPAP2C(1), SGMS1(4), SGPP2(3), SMPD1(1), SMPD3(2), SPHK2(2), SPTLC2(2), UGT8(1)	3228152	35	28	35	30	24	1	2	5	3	0	0.947	1.000	1.000
442	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(4), ABAT(4), ACADS(2), ACSM1(6), AKR1B10(3), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH5A1(2), ALDH7A1(2), BDH1(1), DDHD1(2), GAD1(3), GAD2(1), HADHA(1), HMGCL(1), HMGCS2(3), HSD17B4(1), HSD3B7(2), ILVBL(2), OXCT1(1), PDHA1(1), PDHA2(2), PDHB(1), PLA1A(2), PRDX6(2), RDH13(1)	3705372	56	28	55	32	36	5	6	4	5	0	0.591	1.000	1.000
443	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(2), AARS2(2), CARS(1), CARS2(1), DARS(4), DARS2(1), EPRS(2), FARS2(2), FARSA(1), FARSB(1), HARS(3), IARS2(5), LARS(2), LARS2(2), NARS2(1), QARS(2), SARS(1), TARS2(2), VARS(7), VARS2(1), WARS(1), WARS2(2)	4990522	46	28	44	23	26	4	3	6	7	0	0.535	1.000	1.000
444	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(1), DAXX(3), EGF(4), EGFR(6), ETS1(1), ETS2(3), FOS(1), HRAS(1), MAP2K1(4), MAP2K3(2), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K14(2), MAP3K5(3), MAPK1(3), MAPK3(1), NFKB1(3), PPP2CA(1), PRKCA(1), PRKCD(1), PRKCG(4), PRKCH(1), PRKCQ(4), RAF1(2), RELA(2), RIPK1(1), TNFRSF1A(1), TNFRSF1B(2)	4457402	61	28	61	31	36	6	3	9	7	0	0.581	1.000	1.000
445	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(5), ALDH3A1(1), ALDH3B2(1), AOC2(2), AOC3(2), DDC(2), EPX(2), GOT2(3), HPD(1), LPO(2), MAOB(2), MPO(1), PRDX2(2), PRDX6(2), TAT(5), TPO(8)	1992954	41	28	41	26	28	5	3	1	4	0	0.427	1.000	1.000
446	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(2), FOS(1), IRAK1(1), MAP2K3(2), MAP2K4(1), MAP3K1(1), MAP3K14(2), MAP3K7(1), MYD88(1), NFKB1(3), PPARA(2), RELA(2), TLR10(3), TLR2(3), TLR3(2), TLR4(12), TLR6(1), TLR7(3), TLR9(5)	3295536	48	28	48	21	32	3	3	5	5	0	0.285	1.000	1.000
447	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(2), BTK(4), CALM1(1), CD79B(1), FOS(1), HRAS(1), LYN(1), MAP2K1(4), MAP3K1(1), MAPK3(1), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), PRKCA(1), RAC1(3), RAF1(2), SOS1(1), SYK(3), SYT1(4), VAV1(3)	3481500	45	27	44	28	28	1	5	4	7	0	0.888	1.000	1.000
448	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD2(3), CD33(4), CD5(3), IFNB1(2), IL10(1), IL12A(1), IL5(1), ITGAX(1), TLR2(3), TLR4(12), TLR7(3), TLR9(5)	1688098	42	27	41	24	29	1	3	4	5	0	0.239	1.000	1.000
449	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10(2), ALG10B(1), ALG13(2), ALG2(2), ALG3(2), ALG5(1), ALG8(1), DDOST(1), DOLPP1(1), FUT8(1), GANAB(1), MAN1A1(4), MAN1A2(2), MAN1B1(1), MAN1C1(1), MAN2A1(2), MGAT2(2), MGAT3(3), MGAT4A(1), MGAT5(2), RFT1(1), RPN2(1), STT3B(2)	3859166	37	27	37	27	17	3	6	6	5	0	0.893	1.000	1.000
450	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(8), AGTR1(4), AGTR2(2), ANPEP(3), CMA1(1), CPA3(5), CTSA(1), ENPEP(8), LNPEP(3), MME(5), REN(1), THOP1(1)	1918333	42	27	41	29	30	2	3	0	7	0	0.657	1.000	1.000
451	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADRBK2(1), ARRB2(2), CALM1(1), CALML3(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CLCA1(1), CLCA4(4), CNGA3(4), CNGA4(4), CNGB1(4), GUCA1A(1), GUCA1B(1), GUCA1C(1), PDE1C(11), PRKACA(1), PRKACG(2), PRKG1(1), PRKG2(3), PRKX(1)	2749888	48	27	46	32	33	1	2	9	3	0	0.765	1.000	1.000
452	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ACTG2(3), ADCY9(1), ARL4D(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(8), ATP6V0D2(3), ATP6V1A(1), ATP6V1C2(3), ATP6V1G3(1), ATP6V1H(1), ERO1L(2), GNAS(6), PLCG2(6), PRKCA(1), SEC61A1(2)	3380926	43	27	42	20	27	3	3	5	5	0	0.192	1.000	1.000
453	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(4), ACACA(7), ACADL(2), ACADM(2), ACADSB(1), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), HADHA(1), LDHA(2), MUT(1), PCCB(1), SUCLG1(1)	3031698	33	27	33	18	19	0	7	6	1	0	0.712	1.000	1.000
454	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(3), ALOX12(1), ALOX15(1), ALOX5(2), CYP4F2(2), CYP4F3(6), EPX(2), GGT1(1), LPO(2), LTA4H(1), MPO(1), PLA2G1B(1), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), PRDX2(2), PRDX6(2), PTGIS(5), PTGS1(3), PTGS2(3), TBXAS1(2), TPO(8)	2540980	58	27	58	34	40	7	1	7	3	0	0.338	1.000	1.000
455	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(4), EIF2B1(1), EIF2B2(1), EIF2B5(1), FLT1(9), FLT4(5), HIF1A(2), HRAS(1), KDR(10), NOS3(2), PIK3CA(1), PRKCA(1), PTK2(3), VHL(1)	3106456	42	27	41	24	22	5	1	5	9	0	0.728	1.000	1.000
456	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(5), CALM1(1), FOS(1), GNAQ(1), GNAS(6), HRAS(1), MAP2K1(4), MAPK3(1), NFATC1(2), NFATC2(1), NFATC3(1), NFATC4(7), PRKACG(2), PRKAR2B(1), PRKCA(1), RAF1(2), RPS6KA3(1), SYT1(4)	3160214	42	26	41	26	29	2	3	2	6	0	0.765	1.000	1.000
457	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AKR1B10(3), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), BBOX1(1), DOT1L(1), EHMT1(1), EHMT2(1), GCDH(2), HADHA(1), HSD17B4(1), HSD3B7(2), NSD1(3), OGDH(2), OGDHL(9), PLOD1(1), PLOD2(1), RDH13(1), SETD1A(5), SETDB1(4), SHMT2(1)	5262983	49	26	49	23	30	5	5	5	4	0	0.377	1.000	1.000
458	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(4), ACACA(7), ACACB(7), ACADM(2), ACSS2(1), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), ALDH7A1(2), HADHA(1), LDHA(2), LDHAL6B(2), MUT(1), PCCB(1), SUCLG1(1)	3632300	38	26	38	20	17	4	8	7	2	0	0.652	1.000	1.000
459	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(2), BTG1(2), CRY1(1), EIF4G2(1), ETV6(4), GSTP1(1), HSPA8(2), MYF6(3), NCKAP1(2), NCOA4(3), NR1D2(3), PER1(3), PER2(1), PIGF(1), PPP2CB(1), TOB1(1), VAPA(1), ZFR(1)	3326605	33	25	33	17	16	3	3	7	4	0	0.828	1.000	1.000
460	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(2), F2(4), F2R(2), F5(7), F7(3), FGA(8), FGG(2), PROS1(2), SERPINC1(1), TFPI(4)	1499136	35	25	35	15	19	5	4	2	5	0	0.396	1.000	1.000
461	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(5), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B2(1), AOC2(2), AOC3(2), ASPA(3), CNDP1(1), DDC(2), HAL(3), HARS(3), HDC(5), MAOB(2)	2207941	39	25	39	23	28	1	4	2	4	0	0.485	1.000	1.000
462	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(5), ACY1(1), ADC(1), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), AOC2(2), AOC3(2), ASL(3), ASS1(2), CPS1(4), GATM(1), MAOB(2), NAGS(1), OTC(1)	2655672	33	25	33	24	22	3	3	2	3	0	0.824	1.000	1.000
463	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(2), ASL(3), ASS1(2), CKM(1), CKMT2(1), CPS1(4), DAO(1), EPRS(2), GAMT(1), GATM(1), GOT2(3), LAP3(1), NOS1(11), NOS3(2), OAT(1), OTC(1), P4HA1(2), P4HA3(2), PYCR1(1)	3255679	42	25	41	29	23	8	0	7	4	0	0.864	1.000	1.000
464	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), DPYD(15), DPYS(2), ENPP3(4), ILVBL(2), PANK1(1), PANK4(1), UPB1(2), VNN1(1)	1579004	29	25	28	14	18	3	1	5	2	0	0.473	1.000	1.000
465	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	FUCA1(1), GALNS(1), GBA(1), GLB1(1), HEXA(1), HEXB(1), HGSNAT(1), HPSE(3), HPSE2(1), HYAL1(2), IDS(1), IDUA(1), LCT(6), MAN2B1(2), MAN2B2(3), NEU2(2), NEU3(1), NEU4(4), SPAM1(5)	3111131	38	25	38	25	27	3	0	4	4	0	0.739	1.000	1.000
466	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(6), EP300(4), IL1B(2), MAP2K3(2), MAP3K14(2), MAP3K7(1), MYD88(1), NFKB1(3), NR3C1(2), RELA(2), TGFBR2(3), TLR2(3)	2710429	31	25	31	13	17	5	2	5	2	0	0.500	1.000	1.000
467	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), DIAPH2(1), MCM10(2), MCM2(2), MCM3(3), MCM4(1), MCM5(1), ORC1L(1), ORC2L(1), ORC3L(1), ORC4L(2), ORC6L(1), POLA2(3), POLD1(2), POLD3(1), POLE(1), POLE2(1), RPA1(1), RPA4(1), UBC(1)	4610390	28	24	28	18	17	1	1	6	3	0	0.856	1.000	1.000
468	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B10(3), ALDOB(2), FBP2(1), FPGT(1), FUK(2), HK1(1), HK2(1), HK3(2), HSD3B7(2), LHPP(1), MPI(1), MTMR1(2), PFKFB1(1), PFKFB2(2), PFKFB4(1), PGM2(2), PMM1(2), PMM2(1), RDH13(1), SORD(2)	3371685	31	24	31	26	18	5	4	2	2	0	0.858	1.000	1.000
469	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(1), ALPP(1), ALPPL2(4), ASCC3(1), DDX18(1), DDX19A(1), DDX23(1), DDX4(2), DDX41(1), DDX50(2), DDX51(2), DDX52(1), DHX58(1), EP400(6), FPGS(1), IFIH1(2), MOV10L1(5), QDPR(1), RUVBL2(1), SETX(3), SKIV2L2(1), SMARCA2(4), SMARCA5(1)	5682795	46	24	46	23	29	1	3	8	5	0	0.484	1.000	1.000
470	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(4), ABP1(5), AOC2(2), AOC3(2), CES1(5), CES7(6), DDHD1(2), MYST3(4), MYST4(1), PLA1A(2), PRDX6(2)	2313120	35	24	34	16	24	1	2	2	6	0	0.421	1.000	1.000
471	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(3), ANAPC10(1), ANAPC2(2), ANAPC4(2), ANAPC7(1), CDC16(1), CDC27(5), CUL1(1), CUL3(2), FBXW7(1), FZR1(2), ITCH(1), SKP2(1), SMURF1(1), SMURF2(3), UBA1(1), UBE2D3(1), UBE2E2(2), UBE2E3(1), VHL(1), WWP1(1), WWP2(1)	3633636	35	24	35	13	18	2	4	3	7	1	0.402	1.000	1.000
472	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	BCL2(1), CBL(3), CFLAR(3), E2F1(1), FOS(1), HRAS(1), IL2RA(1), IL2RG(1), IRS1(3), JAK1(1), JAK3(2), MAPK1(3), MAPK3(1), MYC(2), PIK3CA(1), PPIA(1), RAF1(2), RPS6KB1(1), SOCS3(1), SOS1(1), STAT5B(1), SYK(3)	3282894	35	24	35	18	15	4	5	6	5	0	0.734	1.000	1.000
473	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(2), ADCY1(5), CDC25C(2), GNAS(6), HRAS(1), MAPK1(3), MAPK3(1), MYT1(7), PRKACG(2), PRKAR2B(1), RPS6KA1(3)	1868491	33	24	33	19	25	1	0	2	5	0	0.454	1.000	1.000
474	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(1), HLA-A(2), ITGB1(1), KLRC1(1), KLRC3(4), MAP2K1(4), MAPK3(1), PAK1(1), PIK3CA(1), RAC1(3), SYK(3), VAV1(3)	1688413	25	24	25	19	14	2	1	3	5	0	0.952	1.000	1.000
475	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), DPYD(15), DPYS(2), ENPP3(4), PANK1(1), PANK4(1), UPB1(2)	1272385	26	24	25	13	17	3	1	4	1	0	0.572	1.000	1.000
476	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(5), F2(4), F2R(2), F2RL3(1), GNA12(1), GNAQ(1), MAP3K7(1), PIK3CA(1), PLCB1(13), PRKCA(1)	2356180	30	24	29	21	21	3	0	2	4	0	0.806	1.000	1.000
477	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), BLVRA(1), CP(2), EPRS(2), FECH(3), HMOX2(1), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A7(4), UGT1A8(1), UGT2B15(5), UGT2B4(12)	2519405	37	24	37	23	24	3	3	1	5	1	0.676	1.000	1.000
478	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(5), CD3D(1), CD3G(1), CREBBP(6), GNAS(6), HLA-DRA(3), LCK(4), PRKACG(2), PRKAR2B(1), PTPRC(3), ZAP70(3)	2065365	35	23	35	26	23	3	1	3	5	0	0.889	1.000	1.000
479	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(5), CD3D(1), CD3G(1), CREBBP(6), GNAS(6), HLA-DRA(3), LCK(4), PRKACG(2), PRKAR2B(1), PTPRC(3), ZAP70(3)	2065365	35	23	35	26	23	3	1	3	5	0	0.889	1.000	1.000
480	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GHR(4), HRAS(1), INSR(2), IRS1(3), JAK2(1), MAP2K1(4), MAPK1(3), MAPK3(1), PIK3CA(1), PRKCA(1), RAF1(2), RPS6KA1(3), SLC2A4(1), SOS1(1), SRF(1), STAT5B(1)	3022929	30	23	30	27	14	3	1	6	6	0	0.997	1.000	1.000
481	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(4), ADC(1), ALDH4A1(2), ALDH5A1(2), CAD(3), CPS1(4), EPRS(2), GAD1(3), GAD2(1), GCLC(2), GFPT2(1), GMPS(1), GOT2(3), GSS(1), NADSYN1(1), QARS(2)	3606109	33	23	33	20	18	4	3	5	3	0	0.720	1.000	1.000
482	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IFNB1(2), IL1A(1), IL1B(2), IL1R1(5), IL1RN(2), IL6(1), IRAK1(1), IRAK2(3), IRAK3(2), MAP2K3(2), MAP3K1(1), MAP3K14(2), MAP3K7(1), MYD88(1), NFKB1(3), RELA(2), TGFB1(1), TGFB3(1)	2682743	33	23	33	15	21	4	2	4	2	0	0.373	1.000	1.000
483	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(3), ATP4B(1), ATP6V0A1(2), ATP6V0A4(8), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(3), ATP6V1G3(1), ATP6V1H(1), ATP7A(1), ATP7B(5), COX10(3), COX5B(1), COX6A1(1), NDUFA10(1), NDUFB2(1), NDUFB5(1)	3497533	36	23	36	28	16	5	6	3	6	0	0.947	1.000	1.000
484	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(4), AXIN1(2), CREBBP(6), CTNNB1(1), EP300(4), FZD1(1), LDB1(1), LEF1(1), PITX2(2), TRRAP(9)	3028446	31	23	29	15	16	2	4	4	5	0	0.654	1.000	1.000
485	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(1), BRAF(3), CREB5(2), DUSP9(1), EEF2K(3), MAP2K1(4), MAP2K2(1), MAPK1(3), MAPK3(1), NFKB1(3), RAP1A(1), RPS6KA1(3), RPS6KA3(1), SOS1(1), SOS2(2)	2682994	30	23	30	12	19	0	2	5	4	0	0.345	1.000	1.000
486	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(5), ADRB2(1), CFTR(11), GNAS(6), PRKACG(2), PRKAR2B(1), SLC9A3R1(1)	1179243	27	22	26	19	18	2	1	3	3	0	0.776	1.000	1.000
487	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(1), CALM1(1), GNAQ(1), HRAS(1), MAP2K1(4), MAP2K2(1), MAP2K3(2), MAP2K4(1), MAP3K1(1), MAPK1(3), MAPK3(1), PAK1(1), PRKCA(1), RAC1(3), RAF1(2), SOS1(1), SYT1(4)	2593084	29	22	28	24	20	1	1	2	5	0	0.970	1.000	1.000
488	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(4), EEF1B2(1), EEF1D(1), EEF2K(3), EIF1AX(1), EIF2AK1(1), EIF2AK2(1), EIF2AK3(3), EIF2B1(1), EIF2B2(1), EIF2B5(1), EIF4A1(1), EIF4A2(1), EIF4G1(3), EIF4G3(2), EIF5(1), EIF5B(1), GSPT2(1), KIAA0664(1), PABPC3(1)	3968528	30	22	30	17	9	3	2	7	9	0	0.866	1.000	1.000
489	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ABAT(4), ACADS(2), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH5A1(2), GAD1(3), GAD2(1), HADHA(1), HMGCL(1), OXCT1(1), PDHA1(1), PDHA2(2), PDHB(1)	2362677	29	21	28	17	19	2	3	4	1	0	0.676	1.000	1.000
490	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(3), EGF(4), EGFR(6), MET(6), PDGFRA(7), PRKCA(1)	1776448	27	21	27	13	18	1	3	3	2	0	0.473	1.000	1.000
491	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(5), CAMK2B(2), CAMK2D(1), CAMK2G(1), GNAS(6), HRAS(1), MAPK1(3), MAPK3(1), PIK3CA(1), PRKACG(2), PRKAR2B(1), PRKCA(1), RAC1(3), RPS6KA1(3), SOS1(1)	2635171	32	21	32	22	24	2	0	2	4	0	0.835	1.000	1.000
492	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(4), ALDH4A1(2), ALDH5A1(2), CAD(3), CPS1(4), EPRS(2), GAD1(3), GAD2(1), GCLC(2), GMPS(1), GOT2(3), GSS(1), NADSYN1(1), QARS(2)	3033256	31	21	31	15	16	4	3	5	3	0	0.499	1.000	1.000
493	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT2(1), EXTL1(1), EXTL3(1), GLCE(2), HS3ST1(2), HS3ST2(3), HS3ST5(1), HS6ST3(2), NDST2(1), NDST3(5), NDST4(8)	1851389	27	21	27	24	18	1	1	5	2	0	0.961	1.000	1.000
494	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(1), CREBBP(6), EP300(4), FYN(2), IL2RG(1), IL7(2), IL7R(6), JAK1(1), JAK3(2), LCK(4), PIK3CA(1), STAT5B(1)	2540963	31	21	30	18	15	5	1	7	3	0	0.837	1.000	1.000
495	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT2(4), AKT3(2), IL2RG(1), IL4R(6), INPP5D(7), JAK1(1), JAK2(1), JAK3(2), NR0B2(1), PI3(1), PIK3CA(1), PPP1R13B(2), RPS6KB1(1), SOS1(1), SOS2(2), STAT6(1), TYK2(3)	3353409	37	21	37	17	22	3	3	5	4	0	0.477	1.000	1.000
496	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(2), GBA3(6), LPO(2), MPO(1), PRDX2(2), PRDX6(2), TPO(8)	882830	23	21	22	12	17	3	1	0	2	0	0.293	1.000	1.000
497	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(4), AXIN1(2), CREBBP(6), CSNK1A1(1), CTNNB1(1), FZD1(1), MAP3K7(1), MYC(2), NLK(3), PPARD(1), PPP2CA(1), TLE1(1), WIF1(2)	2661277	26	21	25	13	15	1	3	2	5	0	0.673	1.000	1.000
498	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(8), AGTR1(4), AGTR2(2), BDKRB2(3), KNG1(3), NOS3(2), REN(1)	897635	23	20	22	19	14	2	1	3	3	0	0.814	1.000	1.000
499	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(5), BAX(2), BCL2(1), CSF2RB(3), IGF1(2), IGF1R(1), IL3RA(1), KIT(2), KITLG(4), PIK3CA(1), PRKACG(2), PRKAR2B(1)	1993320	25	20	25	20	15	5	1	0	4	0	0.858	1.000	1.000
500	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(2), DRD1(3), DRD2(2), GRM1(3), PLCB1(13), PPP1R1B(1), PPP2CA(1), PRKACG(2), PRKAR2B(1)	1452189	28	20	27	20	20	0	2	4	2	0	0.758	1.000	1.000
501	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(2), GBA(1), GBA3(6), LPO(2), MPO(1), PRDX6(2), TPO(8)	768114	22	20	21	12	15	3	1	0	3	0	0.308	1.000	1.000
502	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(1), ALDH1A1(2), ALDH1A2(2), ALDH1B1(1), ALDH2(2), ALDH3A1(1), ALDH3A2(2), BBOX1(1), DOT1L(1), EHMT1(1), EHMT2(1), GCDH(2), HADHA(1), PLOD1(1), PLOD2(1), SHMT2(1)	3347897	22	20	22	17	15	2	2	3	0	0	0.865	1.000	1.000
503	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	UCHL3(1), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A7(4), UGT1A8(1), UGT2B15(5), UGT2B4(12)	1615139	28	20	28	23	19	3	2	0	3	1	0.888	1.000	1.000
504	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	ATF1(1), CREB5(2), DUSP10(2), EEF2K(3), IL1R1(5), MAP2K3(2), MAP2K4(1), MAP3K4(3), MAP3K5(3), MAP3K7(1), MAPK1(3), MAPKAPK2(2), NFKB1(3), SRF(1)	3035313	32	20	31	15	22	1	1	3	5	0	0.364	1.000	1.000
505	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), CHAT(3), COMT(1), DBH(4), DDC(2), GAD1(3), GAD2(1), HDC(5), PAH(3), SLC18A3(1), TH(1), TPH1(2)	1291618	27	19	27	15	20	2	2	0	3	0	0.319	1.000	1.000
506	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(3), CYP11A1(4), CYP11B1(3), CYP11B2(6), CYP21A2(4), HSD11B1(3), HSD11B2(1), HSD3B2(3)	894911	30	19	28	17	20	2	3	3	2	0	0.279	1.000	1.000
507	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	EIF4A1(1), EIF4A2(1), EIF4G1(3), EIF4G2(1), EIF4G3(2), GHR(4), IRS1(3), MAPK1(3), MAPK3(1), PIK3CA(1), PRKCA(1), PTEN(4), RPS6KB1(1)	2582590	26	19	26	14	8	5	4	2	7	0	0.807	1.000	1.000
508	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSD(1), ARSE(1), GAL3ST1(1), GBA(1), GLB1(1), LCT(6), NEU2(2), NEU3(1), NEU4(4), PPAP2C(1), SMPD1(1), SPTLC2(2)	2179189	22	19	22	17	16	1	0	3	2	0	0.853	1.000	1.000
509	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(2), FBP2(1), G6PD(1), H6PD(3), PGD(2), PRPS1L1(4), RBKS(1), TALDO1(2), TKT(1), TKTL2(5)	2211954	22	19	22	21	13	2	1	3	3	0	0.923	1.000	1.000
510	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(3), CYP11A1(4), CYP11B1(3), CYP11B2(6), CYP21A2(4), HSD11B1(3), HSD11B2(1), HSD3B2(3)	894911	30	19	28	17	20	2	3	3	2	0	0.279	1.000	1.000
511	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS2(5), ILVBL(2), LARS(2), LARS2(2), PDHA1(1), PDHA2(2), PDHB(1), VARS(7), VARS2(1)	1722323	24	19	22	11	10	5	1	4	4	0	0.560	1.000	1.000
512	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(3), ABCC2(2), ABCG2(1), CES1(5), CES2(1), CYP3A4(4), CYP3A5(3), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A7(4), UGT1A8(1)	2089952	29	19	28	20	17	4	2	2	4	0	0.687	1.000	1.000
513	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	FOS(1), HRAS(1), JAK1(1), MAP2K1(4), MAP2K4(1), MAP3K1(1), MAPK3(1), PDGFRA(7), PIK3CA(1), PRKCA(1), RAF1(2), RASA1(3), SOS1(1), SRF(1), STAT1(2)	3175759	28	19	28	21	12	3	0	6	7	0	0.991	1.000	1.000
514	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(5), ADRB2(1), GNAS(6), PLCE1(11), PRKACG(2), PRKAR2B(1)	1328016	26	19	26	14	16	3	2	3	2	0	0.522	1.000	1.000
515	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), EGR2(1), GNAQ(1), MAP3K1(1), MYC(2), NFATC1(2), NFATC2(1), NFKB1(3), PRKACG(2), PRKAR2B(1), RELA(2), SYT1(4), VIP(1), VIPR2(2)	2539456	24	19	23	19	17	2	2	2	1	0	0.913	1.000	1.000
516	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(5), GNAS(6), PPP2CA(1), PRKAA2(5), PRKAB2(1), PRKACG(2), PRKAG1(1), PRKAG2(1), PRKAR2B(1)	1389164	23	18	23	16	17	2	2	0	2	0	0.784	1.000	1.000
517	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGF(4), EGFR(6), FOS(1), HRAS(1), JAK1(1), MAP2K1(4), MAP2K4(1), MAP3K1(1), MAPK3(1), PIK3CA(1), PRKCA(1), RAF1(2), RASA1(3), SOS1(1), SRF(1), STAT1(2)	3410636	31	18	31	18	15	3	2	5	6	0	0.940	1.000	1.000
518	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOB(2), FBP2(1), FPGT(1), GCK(3), HK1(1), HK2(1), HK3(2), MPI(1), PFKFB1(1), PFKFB4(1), PMM1(2), PMM2(1), SORD(2)	2172235	19	18	19	19	8	6	3	0	2	0	0.907	1.000	1.000
519	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	BCL2(1), BCR(2), FOS(1), HRAS(1), JAK2(1), MAP2K1(4), MAP2K4(1), MAP3K1(1), MAPK3(1), MYC(2), PIK3CA(1), RAF1(2), SOS1(1), STAT1(2), STAT5B(1)	2549541	22	18	22	15	10	2	0	4	6	0	0.962	1.000	1.000
520	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	CABIN1(2), CALM1(1), CAMK1G(3), HDAC5(2), IGF1(2), IGF1R(1), INSR(2), MAPK7(2), MEF2A(2), MEF2B(1), MEF2C(1), MEF2D(2), MYOD1(1), NFATC1(2), NFATC2(1), PIK3CA(1), SYT1(4)	3175365	30	18	29	19	18	5	3	2	2	0	0.749	1.000	1.000
521	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(1), CHIT1(4), CTBS(3), CYB5R1(1), GFPT2(1), GNE(2), HEXA(1), HEXB(1), HK1(1), HK2(1), HK3(2), LHPP(1), MTMR1(2), UAP1(1)	2616103	22	18	22	15	15	2	0	3	2	0	0.781	1.000	1.000
522	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GALNS(1), GLB1(1), HEXA(1), HEXB(1), HGSNAT(1), HPSE(3), HPSE2(1), HYAL1(2), IDS(1), IDUA(1), LCT(6), SPAM1(5)	1848200	24	18	24	20	18	1	0	3	2	0	0.921	1.000	1.000
523	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT2(3), AGPAT4(3), AGPAT6(1), AGPS(1), CHPT1(1), ENPP6(1), PAFAH1B1(1), PAFAH2(1), PLA2G1B(1), PLA2G2D(1), PLA2G2F(2), PLA2G3(4), PLA2G4A(2), PLA2G5(1), PLA2G6(3), PLD1(2), PLD2(3), PPAP2C(1)	2126785	32	18	32	19	19	1	2	7	3	0	0.744	1.000	1.000
524	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(2), FBP2(1), GOT2(3), MDH2(1), ME1(3), ME3(1), PGK2(5), PKLR(2), PKM2(1), TKT(1), TKTL2(5)	1850268	25	18	25	20	16	3	2	2	2	0	0.807	1.000	1.000
525	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(17), CYP2C9(9)	183881	26	18	25	16	19	1	2	1	3	0	0.575	1.000	1.000
526	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	FOS(1), HRAS(1), IL2(1), IL2RA(1), IL2RG(1), JAK1(1), JAK3(2), LCK(4), MAP2K1(4), MAPK3(1), RAF1(2), SOS1(1), STAT5B(1), SYK(3)	2097971	24	18	24	13	13	0	1	6	4	0	0.803	1.000	1.000
527	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), ALG5(1), B4GALT5(2), DDOST(1), FUT8(1), MAN1A1(4), MAN1B1(1), MGAT2(2), MGAT3(3), MGAT4A(1), MGAT5(2), RPN2(1)	1825212	21	18	21	16	11	2	1	6	1	0	0.891	1.000	1.000
528	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(3), CREBBP(6), EP300(4), NCOA3(2), PRKACG(2), PRKAR2B(1), RXRA(1)	1889869	19	17	19	10	12	1	1	4	1	0	0.750	1.000	1.000
529	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(3), ACTN3(2), BCAR1(1), CTNNA2(4), CTNNB1(1), PTK2(3), VCL(3)	1721109	18	17	18	16	7	1	2	4	4	0	0.921	1.000	1.000
530	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(1), CALM1(1), GNAS(6), NFKB1(3), NOS3(2), NPPA(1), NR3C1(2), PIK3CA(1), RELA(2), SYT1(4)	1614263	23	17	22	15	15	3	0	4	1	0	0.875	1.000	1.000
531	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	FUCA1(1), GLB1(1), HEXA(1), HEXB(1), LCT(6), MAN2B1(2), MAN2B2(3), NEU2(2), NEU3(1), NEU4(4)	1853191	22	17	22	11	17	2	0	2	1	0	0.405	1.000	1.000
532	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLA2(3), POLD1(2), POLD3(1), POLE(1), POLE2(1), POLG(1), POLG2(1), POLK(2), POLL(1), POLQ(5), PRIM2(3), REV3L(3)	3689119	25	17	25	13	10	1	2	10	2	0	0.802	1.000	1.000
533	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG5(1), ATG7(1), BECN1(2), IFNA16(1), IFNA2(1), IFNA21(1), IFNA4(1), IFNA8(1), PIK3C3(2), PIK3R4(3), PRKAA2(5), ULK1(2), ULK2(1)	1896740	23	17	23	13	19	1	1	1	1	0	0.553	1.000	1.000
534	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(2), CASP3(1), CASP7(3), CASP8(2), GAPDH(1), INSR(2), ITCH(1), MAGI1(3), MAGI2(5), RERE(6), WWP1(1), WWP2(1)	2195354	28	17	27	15	15	2	1	5	4	1	0.764	1.000	1.000
535	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	FOS(1), HRAS(1), IL6(1), IL6R(2), IL6ST(2), JAK1(1), JAK2(1), JAK3(2), MAP2K1(4), MAPK3(1), PTPN11(1), RAF1(2), SOS1(1), SRF(1)	2164669	21	17	21	16	10	0	0	5	6	0	0.990	1.000	1.000
536	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	GLI2(9), GLI3(3), PRKACG(2), PRKAR2B(1), SHH(1), SMO(1)	1510601	17	17	17	14	12	1	2	1	1	0	0.867	1.000	1.000
537	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K4(1), MAP2K7(1), MAPK1(3), MAPK10(2), MAPK3(1), MAPK8IP2(2), MAPK8IP3(3), NFKB1(3), NFKB2(2), NFKBIL2(2), PIK3CA(1), PIK3CD(1), SYT1(4), TRAF5(2)	3050574	28	17	27	18	21	1	1	3	2	0	0.644	1.000	1.000
538	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(1), ARFGAP3(2), ARFGEF2(9), CLTB(1), COPA(1), GBF1(1), GPLD1(5)	1494678	20	16	20	11	12	1	1	4	2	0	0.695	1.000	1.000
539	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	AGTR2(2), EDNRA(2), EDNRB(1), EGF(4), EGFR(6), FOS(1), HRAS(1), MYC(2), NFKB1(3), PRKCA(1), RELA(2)	1872104	25	16	25	12	15	2	2	3	3	0	0.546	1.000	1.000
540	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3D(1), CD3G(1), CD80(1), CD86(7), CTLA4(2), HLA-DRA(3), IL2(1), ITK(3), LCK(4), PIK3CA(1), PTPN11(1)	1164652	25	16	25	14	16	2	0	3	4	0	0.770	1.000	1.000
541	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(2), EPX(2), LPO(2), MPO(1), PRDX6(2), SHMT2(1), TPO(8)	1068663	19	16	19	11	14	3	1	0	1	0	0.377	1.000	1.000
542	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(6), ENPP3(4), NADK(1), NADSYN1(1), NNMT(1), NNT(3), NT5C1A(1), NT5C1B(4), NT5C2(1), QPRT(2)	1969464	24	16	24	17	16	2	1	3	2	0	0.829	1.000	1.000
543	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	FOS(1), HRAS(1), IGF1(2), IGF1R(1), IRS1(3), MAP2K1(4), MAPK3(1), PIK3CA(1), PTPN11(1), RAF1(2), RASA1(3), SOS1(1), SRF(1)	2254539	22	16	22	12	7	6	1	3	5	0	0.879	1.000	1.000
544	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	FOS(1), HRAS(1), INSR(2), IRS1(3), MAP2K1(4), MAPK3(1), PIK3CA(1), PTPN11(1), RAF1(2), RASA1(3), SLC2A4(1), SOS1(1), SRF(1)	2331283	22	16	22	17	7	4	1	5	5	0	0.991	1.000	1.000
545	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(7), CPT1A(2), LEPR(7), PRKAA2(5), PRKAB2(1), PRKAG1(1), PRKAG2(1)	1332085	24	16	23	16	16	1	2	2	3	0	0.868	1.000	1.000
546	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CAMK1G(3), CAMK2B(2), CAMK2D(1), CAMK2G(1), CAMK4(1), HDAC5(2), MEF2A(2), MEF2B(1), MEF2C(1), MEF2D(2), PPARA(2), SLC2A4(1), SYT1(4)	1828919	24	16	23	14	19	0	0	3	2	0	0.608	1.000	1.000
547	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(4), APOA4(1), APOC1(1), APOE(1), CYP7A1(1), DGAT1(1), LDLR(2), LIPC(1), LPL(1), LRP1(10), SCARB1(2)	2519691	25	16	25	17	13	2	2	5	3	0	0.774	1.000	1.000
548	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	FOS(1), HRAS(1), JAK2(1), MAP2K1(4), MAPK3(1), MPL(2), PIK3CA(1), PRKCA(1), RAF1(2), RASA1(3), SOS1(1), STAT1(2), STAT5B(1), THPO(1)	2722971	22	16	22	17	9	3	0	6	4	0	0.990	1.000	1.000
549	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(2), CARS(1), DARS(4), EPRS(2), FARS2(2), HARS(3), LARS(2), LARS2(2), QARS(2), SARS(1), WARS(1), WARS2(2)	2936980	24	15	23	13	14	2	1	3	4	0	0.685	1.000	1.000
550	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(5), FHL5(3), FSHB(2), FSHR(3), GNAS(6)	863028	19	15	19	15	15	1	0	0	3	0	0.865	1.000	1.000
551	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(1), ASRGL1(1), CA1(2), CA13(1), CA2(2), CA3(1), CA4(1), CA6(1), CA8(2), CA9(1), CPS1(4), HAL(3)	1920487	20	15	20	10	14	2	0	1	3	0	0.454	1.000	1.000
552	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD2(3), CD3D(1), CD3G(1), CXCR3(1), IL12A(1), IL12RB1(3), IL12RB2(1), JAK2(1), STAT4(1), TYK2(3)	1320077	16	15	16	10	8	4	0	2	2	0	0.720	1.000	1.000
553	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(2), FBP2(1), G6PD(1), H6PD(3), PGD(2), PRPS1L1(4), RBKS(1), TALDO1(2), TKT(1)	1860980	17	15	17	15	9	1	1	3	3	0	0.883	1.000	1.000
554	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(1), PLCB1(13), PRKCA(1), VAV1(3)	1172746	18	15	17	13	15	1	0	1	1	0	0.830	1.000	1.000
555	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CRADD(1), MAP2K3(2), MAP2K4(1), MAP3K1(1), MAP3K14(2), MAP4K2(1), NFKB1(3), RELA(2), RIPK1(1), TNFRSF1A(1)	2168429	16	15	16	11	8	3	0	3	2	0	0.846	1.000	1.000
556	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD3G(1), FYN(2), HLA-DRA(3), LCK(4), PTPRC(3), ZAP70(3)	806388	17	15	17	11	10	2	0	3	2	0	0.720	1.000	1.000
557	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD3D(1), CD3G(1), CD8A(1), ICAM1(1), ITGAL(3), ITGB2(4), PTPRC(3)	966925	17	15	17	14	9	2	0	2	4	0	0.871	1.000	1.000
558	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD3D(1), CD3G(1), ICAM1(1), ITGAL(3), ITGB2(4), PTPRC(3)	1013444	16	15	16	14	8	2	0	2	4	0	0.900	1.000	1.000
559	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(1), ALOX15(1), ALOX15B(1), ALOX5(2), GGT1(1), LTA4H(1), PLA2G6(3), PTGIS(5), PTGS1(3), PTGS2(3), TBXAS1(2)	1358531	23	14	23	15	12	4	0	6	1	0	0.597	1.000	1.000
560	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(4), CYP11B2(6), HSD11B1(3), HSD11B2(1), HSD3B2(3)	628487	18	14	17	14	14	1	0	1	2	0	0.476	1.000	1.000
561	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), GPR109B(1), GPR161(1), GPR171(1), GPR39(5), GPR45(2), GPR65(1), GPR68(2), GPR75(1)	889040	16	14	16	13	13	1	1	1	0	0	0.592	1.000	1.000
562	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(3), FOS(1), HRAS(1), IL3RA(1), JAK2(1), MAP2K1(4), MAPK3(1), RAF1(2), SOS1(1), STAT5B(1)	1601865	16	14	16	15	8	0	0	3	5	0	0.991	1.000	1.000
563	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(8), MAP2(1), PPP2CA(1), PRKACG(2), PRKAG1(1), PRKAR2B(1)	1650272	14	13	14	13	9	1	2	0	2	0	0.975	1.000	1.000
564	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CAMK1G(3), CAMK2B(2), CAMK2D(1), CAMK2G(1), CAMK4(1), CAMKK1(1), CAMKK2(3), SYT1(4)	1059881	17	13	16	10	12	1	0	3	1	0	0.569	1.000	1.000
565	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	HRAS(1), MAPK1(3), MAPK3(1), MAPK7(2), MEF2A(2), MEF2B(1), MEF2C(1), MEF2D(2), NTRK1(2), PIK3CA(1), RPS6KA1(3)	1724673	19	13	19	13	12	3	0	1	3	0	0.833	1.000	1.000
566	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(1), LCT(6), MPI(1), PYGL(3), PYGM(3), TREH(1)	1203045	15	13	15	15	11	2	0	2	0	0	0.882	1.000	1.000
567	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA1(2), GABRA2(1), GABRA3(8), GABRA4(1), GABRA6(3), GPHN(1), UBQLN1(1)	1068362	17	13	17	19	12	2	1	0	2	0	0.981	1.000	1.000
568	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	GLB1(1), HEXA(1), HEXB(1), LCT(6), SLC33A1(1), ST3GAL1(2), ST3GAL5(2), ST6GALNAC3(2), ST6GALNAC4(1), ST8SIA5(3)	1503273	20	13	20	11	15	1	0	4	0	0	0.526	1.000	1.000
569	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(6), ENPP3(4), NADSYN1(1), NNMT(1), NNT(3), QPRT(2)	1332269	17	13	17	13	10	2	1	2	2	0	0.862	1.000	1.000
570	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	IKBKAP(2), MAP3K1(1), MAP3K14(2), NFKB1(3), RELA(2), RIPK1(1), TNFAIP3(1), TNFRSF1B(2), TRAF1(1)	2034395	15	13	15	14	7	3	0	4	1	0	0.978	1.000	1.000
571	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(2), FBP2(1), GOT2(3), MDH2(1), ME1(3), ME3(1), PKLR(2), PKM2(1), TKT(1)	1653919	15	12	15	10	8	2	2	1	2	0	0.736	1.000	1.000
572	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	EPO(1), EPOR(1), FOS(1), HRAS(1), JAK2(1), MAP2K1(4), MAPK3(1), RAF1(2), SOS1(1), STAT5B(1)	1942027	14	12	14	13	6	0	1	3	4	0	0.993	1.000	1.000
573	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(2), CRY1(1), NPAS2(1), PER1(3), PER2(1), PER3(4)	1549784	12	12	12	13	10	0	0	1	1	0	0.966	1.000	1.000
574	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22(1), IL22RA1(2), JAK1(1), JAK2(1), JAK3(2), SOCS3(1), STAT1(2), STAT5B(1), TYK2(3)	1660280	14	12	14	13	8	0	1	3	2	0	0.958	1.000	1.000
575	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(3), BIN1(1), CALM1(1), EPN1(3), PICALM(1), SYNJ1(3), SYNJ2(2), SYT1(4)	1958050	18	12	17	16	14	1	0	3	0	0	0.953	1.000	1.000
576	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	BTK(4), LYN(1), PRKCZ(2), RAC1(3), RPS6KB1(1), VAV2(2)	2263093	13	12	13	11	7	0	1	2	3	0	0.855	1.000	1.000
577	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	CHRNB1(1), MUSK(6), PIK3CA(1), PTK2(3), TERT(1)	1478848	12	11	12	18	7	2	0	2	1	0	0.996	1.000	1.000
578	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	CASP9(1), GHR(4), NFKB1(3), PIK3CA(1), PPP2CA(1), RELA(2)	1274349	12	11	12	11	6	3	1	2	0	0	0.963	1.000	1.000
579	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(1), MAPK3(1), OPRK1(3), POLR2A(4), PRKACG(2), PRKAR2B(1)	1168011	12	11	12	15	10	0	1	0	1	0	0.978	1.000	1.000
580	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(2), GABRA2(1), GABRA3(8), GABRA4(1), GABRA6(3)	702169	15	11	15	16	11	2	0	0	2	0	0.961	1.000	1.000
581	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	FOS(1), HRAS(1), MAP2K1(4), MAPK3(1), NGFR(3), PIK3CA(1), RAF1(2), SOS1(1)	1734702	14	11	14	11	7	2	0	2	3	0	0.973	1.000	1.000
582	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(1), IL6R(2), JAK1(1), JAK2(1), JAK3(2), PIAS3(1), PTPRU(2), REG1A(1)	1382782	11	11	11	10	6	1	0	2	2	0	0.936	1.000	1.000
583	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(6), HSD17B2(2), HSD17B3(2), HSD17B4(1), HSD17B7(1), HSD3B2(3)	730707	15	11	15	11	9	2	1	0	3	0	0.718	1.000	1.000
584	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(6), PRKACG(2), PRKAR2B(1), PRKCA(1)	862126	12	10	12	7	10	2	0	0	0	0	0.622	1.000	1.000
585	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	IKBKAP(2), MAP3K1(1), MAP3K14(2), NFKB1(3), RELA(2), TNFAIP3(1)	1645850	11	10	11	12	3	3	0	4	1	0	0.993	1.000	1.000
586	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(3), IL5(1), MAF(1), MAP2K3(2), NFATC1(2), NFATC2(1), PRKACG(2), PRKAR2B(1)	1100580	13	10	13	11	9	2	2	0	0	0	0.802	1.000	1.000
587	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(4), CDO1(1), GAD1(3), GAD2(1), GGT1(1)	515640	10	10	10	8	6	1	1	2	0	0	0.848	1.000	1.000
588	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3D(1), CD3G(1), IL2(1), IL2RA(1), TGFB1(1), TGFB3(1), TGFBR2(3), TGFBR3(3), TOB1(1)	961270	13	10	13	10	11	1	0	0	1	0	0.825	1.000	1.000
589	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(3), PDHA1(1), PDHA2(2), PEMT(1), SLC18A3(1)	625039	9	9	8	9	7	2	0	0	0	0	0.859	1.000	1.000
590	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACOT11(1), DHRS2(2), DHRS3(1), DHRSX(1), GCDH(2), HADHA(1), MYST3(4), MYST4(1)	2382863	13	9	13	13	5	2	0	3	3	0	0.988	1.000	1.000
591	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(1), ATIC(1), GART(4), MTHFD1(2), MTR(1), SHMT2(1)	1730604	10	9	10	10	8	2	0	0	0	0	0.921	1.000	1.000
592	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP6(1), ENPP3(4), FLAD1(2), LHPP(1), MTMR1(2)	1371041	11	9	11	11	6	1	1	2	1	0	0.969	1.000	1.000
593	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	SEC22B(1), SNAP25(3), STX19(1), STX2(2), TSNARE1(2), VAMP4(1), VAMP7(1), VAMP8(1)	1512695	12	9	12	11	6	1	0	4	1	0	0.951	1.000	1.000
594	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	CAT(2), GHR(4), HRAS(1), IGF1(2), IGF1R(1), PIK3CA(1)	1209750	11	9	11	10	6	4	0	0	1	0	0.949	1.000	1.000
595	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(1), ATIC(1), GART(4), MTHFD1(2), MTR(1), SHMT2(1)	1632467	10	9	10	8	8	2	0	0	0	0	0.818	1.000	1.000
596	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CXCL12(1), CXCR4(1), FOS(1), GNAQ(1), PRKCA(1), SYT1(4)	1260945	10	8	9	16	8	0	0	0	2	0	0.994	1.000	1.000
597	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GALNS(1), GLB1(1), HEXA(1), HEXB(1), IDS(1), IDUA(1), LCT(6)	1302089	12	8	12	13	11	0	0	1	0	0	0.948	1.000	1.000
598	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(1), CHST12(1), PAPSS2(1), SULT1A1(1), SULT1A2(1), SULT1E1(3), SULT2A1(2), SULT2B1(1), SUOX(1)	832164	12	7	12	8	10	1	0	1	0	0	0.630	1.000	1.000
599	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(1), ESR1(1), GREB1(2), MTA3(1), PDZK1(1), TUBA8(2)	977301	8	7	8	7	8	0	0	0	0	0	0.695	1.000	1.000
600	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(2), CRY1(1), PER1(3)	766907	6	6	6	6	5	0	0	1	0	0	0.933	1.000	1.000
601	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(6), PNPO(1)	445320	7	6	7	6	6	1	0	0	0	0	0.822	1.000	1.000
602	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(2), NR0B2(1), NR1H4(2), RXRA(1)	495536	6	5	6	7	4	1	0	1	0	0	0.898	1.000	1.000
603	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(2), TPK1(2)	585665	5	5	5	4	5	0	0	0	0	0	0.886	1.000	1.000
604	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(1), FUT2(2), FUT3(1)	455370	4	4	4	4	2	1	0	1	0	0	0.815	1.000	1.000
605	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CSF1(1), IL6(1), LDLR(2), LPL(1)	488132	5	4	5	4	2	1	0	2	0	0	0.842	1.000	1.000
606	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	POLD1(2), POLG(1), RRM1(1)	1134528	4	4	4	8	4	0	0	0	0	0	0.990	1.000	1.000
607	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), OAT(1)	498813	3	3	3	3	0	2	0	1	0	0	0.951	1.000	1.000
608	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	GCDH(2), HADHA(1)	713013	3	3	3	3	1	1	0	1	0	0	0.917	1.000	1.000
609	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(2)	205513	3	3	3	6	3	0	0	0	0	0	0.978	1.000	1.000
610	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), HADHA(1)	442566	2	2	2	3	1	0	0	1	0	0	0.956	1.000	1.000
611	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(1)	630206	2	2	2	3	2	0	0	0	0	0	0.963	1.000	1.000
612	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	HMGCL(1), OXCT1(1)	307069	2	2	2	3	0	1	0	1	0	0	0.977	1.000	1.000
613	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD3D(1), CD3G(1)	291749	2	2	2	5	2	0	0	0	0	0	0.971	1.000	1.000
614	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1), CD3G(1)	102220	2	2	2	3	2	0	0	0	0	0	0.943	1.000	1.000
615	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4		415501	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
616	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		141505	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
