rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(7), CCNE1(1), CCNE2(10), CDK4(2), CDKN2A(16), E2F1(5), E2F2(1), PRB1(14)	1394347	56	41	49	8	29	0	1	12	14	0	0.000507	2.24e-05	0.0102
2	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BRAF(64), CREB5(7), MAPK1(2), RAF1(2), SNX13(1)	1725227	76	63	26	18	21	3	2	50	0	0	0.126	3.31e-05	0.0102
3	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CDK4(2), CDKN1A(1), CDKN2A(16), E2F1(5), E2F2(1), MDM2(2), NXT1(2), PRB1(14), TP53(20)	1308030	63	38	57	10	29	2	2	9	21	0	0.000269	0.000389	0.0799
4	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(4), IL8(1), SLPI(5)	265596	10	10	10	2	4	1	0	4	1	0	0.226	0.0439	1.000
5	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(3), FOSB(5), GRIA2(19)	561071	27	21	24	7	21	1	0	3	2	0	0.0444	0.152	1.000
6	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(6)	110886	6	6	6	2	6	0	0	0	0	0	0.326	0.332	1.000
7	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(1), MYC(2), SP1(3), SP3(1), TP53(20), WT1(4)	1095688	31	23	29	5	14	1	4	4	8	0	0.0238	0.333	1.000
8	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(3), ALDH1A2(8), BCMO1(9), RDH5(1)	601941	21	18	20	5	13	2	1	3	2	0	0.0369	0.382	1.000
9	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(5), DCN(11), FMOD(3), KERA(10), LUM(7)	538277	36	22	36	13	30	3	1	1	1	0	0.0212	0.496	1.000
10	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3)	869053	64	39	58	17	49	4	4	5	2	0	0.00397	0.614	1.000
11	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	EHHADH(5), HADHA(7)	747324	12	11	11	4	8	1	0	3	0	0	0.289	0.640	1.000
12	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(4), CHRNA1(1), SNAP25(5), STX1A(2)	505419	12	9	10	3	8	0	0	1	3	0	0.114	0.688	1.000
13	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(4), CD3E(2)	173837	6	4	6	2	5	0	0	0	1	0	0.415	0.700	1.000
14	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(3), HADHA(7)	847363	12	10	12	2	6	1	1	4	0	0	0.180	0.765	1.000
15	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	79550	1	1	1	1	1	0	0	0	0	0	0.896	0.820	1.000
16	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(2)	256036	2	2	2	1	1	0	0	1	0	0	0.741	0.846	1.000
17	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(3), CDKN2A(16), E2F1(5), MDM2(2), MYC(2), PIK3CA(2), PIK3R1(2), POLR1A(7), POLR1B(4), POLR1C(1), RAC1(7), RB1(3), TBX2(1), TP53(20), TWIST1(1)	3124280	76	43	67	15	41	3	2	8	20	2	0.000481	0.878	1.000
18	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(2), CASP8(1), CFLAR(3), PDE6D(2)	603846	8	7	8	3	3	1	2	2	0	0	0.473	0.884	1.000
19	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	EHHADH(5), HADHA(7), HSD17B10(1), HSD17B4(3), NTAN1(1), SIRT2(1), SIRT5(4), SIRT7(2), VNN2(7)	1824715	31	22	30	6	20	3	3	5	0	0	0.0189	0.887	1.000
20	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(2), MTMR2(1), MTMR6(2), NFS1(3), TPK1(3)	984451	12	11	12	1	9	1	1	0	1	0	0.0473	0.904	1.000
21	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), EHHADH(5), GCDH(3), HADHA(7)	1205056	16	13	15	3	11	2	0	3	0	0	0.0700	0.908	1.000
22	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(1), PSMB4(1), PSMB5(1), PSMB7(1), PSMB8(1)	1362190	14	11	14	1	7	2	2	1	2	0	0.0319	0.922	1.000
23	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2)	239595	2	1	2	0	0	1	0	0	1	0	0.527	0.969	1.000
24	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1), HMGCL(2), OXCT1(3)	518476	6	6	6	2	4	0	0	1	1	0	0.489	0.971	1.000
25	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(2), TGDS(1), UXS1(1)	596534	4	4	4	3	1	0	0	0	3	0	0.935	0.973	1.000
26	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYB(1), RB1(3), SP1(3), SP3(1)	1028377	9	8	9	3	1	1	1	2	2	2	0.586	0.973	1.000
27	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	HADHA(7), HADHB(2), HSD17B10(1), HSD17B4(3), MECR(1), PPT1(3), PPT2(3)	1307025	20	18	20	6	8	2	3	6	1	0	0.279	0.974	1.000
28	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(3), IFNG(2), IL12A(2), IL12B(3), IL18(2), IL2(4)	452751	16	7	16	5	11	2	0	1	2	0	0.152	0.976	1.000
29	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CDC34(3), CUL1(2), E2F1(5), FBXW7(7), RB1(3)	1250998	21	17	21	8	10	2	1	2	4	2	0.355	0.982	1.000
30	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(4), GOT2(2), TAT(10)	406648	16	9	16	5	13	0	2	1	0	0	0.112	0.984	1.000
31	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(2), ALDOA(1), ALDOB(5), ALDOC(1)	609799	9	6	9	3	6	0	0	1	2	0	0.237	0.984	1.000
32	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), IFNG(2), IFNGR1(3), JAK1(4), JAK2(6), PLA2G2A(1), PTPRU(11), REG1A(4), STAT1(2)	1757163	34	20	34	8	19	1	1	7	6	0	0.0303	0.985	1.000
33	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(4), SEC61A2(3), SRP19(1), SRP54(1), SRP68(5), SRP72(1), SRPR(2)	1182709	17	15	15	6	9	0	1	2	5	0	0.496	0.986	1.000
34	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(6), COASY(3), DPYD(33), DPYS(13), ENPP1(7), ENPP3(8), PANK2(1), PANK3(1), PANK4(2), PPCS(3), UPB1(3)	2137161	80	40	74	22	65	4	3	4	4	0	0.00229	0.990	1.000
35	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(5), GGT1(3), SHMT2(2)	623386	10	9	10	5	8	0	0	1	1	0	0.359	0.990	1.000
36	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(3), ACTR2(2), ARPC1B(1), ARPC2(1), ARPC3(1), RAC1(7), WASF1(1), WASL(1)	1251808	17	14	14	4	13	0	1	1	2	0	0.133	0.992	1.000
37	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(3), RAB11A(1), RAB27A(2), RAB3A(2)	650036	8	6	8	2	7	0	1	0	0	0	0.223	0.992	1.000
38	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(2), SQLE(1)	491645	3	3	3	1	2	0	0	1	0	0	0.591	0.993	1.000
39	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(2), TGDS(1), UGP2(1), UXS1(1)	760505	5	5	5	4	2	0	0	0	3	0	0.942	0.994	1.000
40	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(6), BCAT2(1), COASY(3), DPYD(33), DPYS(13), ENPP1(7), ENPP3(8), ILVBL(2), PANK2(1), PANK3(1), PANK4(2), PPCS(3), UPB1(3), VNN1(4)	2650685	87	41	81	22	70	4	3	5	5	0	0.000219	0.994	1.000
41	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	CBS(3), MUT(4)	786471	7	7	7	3	5	0	0	1	1	0	0.567	0.996	1.000
42	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(2), GBA3(5), GGT1(3), SHMT2(2)	823959	13	10	13	5	11	0	0	1	1	0	0.209	0.997	1.000
43	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(7), CCNE1(1), CDC34(3), CUL1(2), E2F1(5), RB1(3)	1311595	21	18	21	9	14	2	0	1	2	2	0.331	0.997	1.000
44	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(3)	478029	5	5	5	4	2	0	1	1	1	0	0.824	0.998	1.000
45	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(2), PRKCA(5), TGM2(4)	765949	12	7	12	5	8	2	0	0	2	0	0.167	0.998	1.000
46	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CUL1(2), E2F1(5), RB1(3), UBE2M(1)	1325895	12	11	12	8	5	2	0	1	2	2	0.772	0.998	1.000
47	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(4), CBS(3), GGT1(3), MARS(4), MARS2(3), MAT1A(4), MAT2B(1), PAPSS1(1), PAPSS2(2), SCLY(2), SEPHS1(3)	1925135	30	22	30	8	17	1	2	6	4	0	0.0447	0.998	1.000
48	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP7(3), DFFA(1), DFFB(2), GZMB(1), HMGB1(1), TOP2A(3), TOP2B(4)	1387495	15	10	15	3	9	1	3	1	1	0	0.147	0.999	1.000
49	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(1), NFKBIA(1), PLCB1(29), PRKCA(5), RELA(1)	1258865	38	26	37	13	32	1	1	2	2	0	0.0922	0.999	1.000
50	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), CYCS(1), GPD2(1), SDHA(1), SDHC(2), UQCRC1(1)	1025912	7	7	7	1	5	0	1	1	0	0	0.186	0.999	1.000
51	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(6), LPL(2), NR3C1(1), PPARG(6), RETN(3), RXRA(1), TNF(1)	898972	20	16	19	8	13	2	0	3	2	0	0.223	0.999	1.000
52	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF2(2), CSF3(1), EPO(4), FLT3(18), IGF1(6), IL11(2), IL1A(2), IL3(2), KITLG(6), TGFB2(1), TGFB3(1)	1265622	45	26	43	14	34	2	2	2	5	0	0.0117	0.999	1.000
53	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(7), CCND2(3), CCNE1(1), CCNH(1), CDC25A(5), CDK4(2), CDKN1A(1), CDKN2A(16), E2F1(5), RB1(3), RBL1(4)	2497998	48	35	44	15	25	1	1	5	14	2	0.0547	0.999	1.000
54	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(5), GOT1(4), GOT2(2), LDHA(2), LDHC(1), MPST(1)	1060191	15	12	15	5	12	0	3	0	0	0	0.181	0.999	1.000
55	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(6), IARS(1), LARS(8), LARS2(3), PDHA1(1), PDHA2(7), PDHB(1)	1553920	27	17	26	6	21	2	0	2	2	0	0.0547	0.999	1.000
56	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(5), EPHX2(4), RDH12(1), RDH13(3)	742692	13	10	13	9	10	0	1	0	2	0	0.571	1.000	1.000
57	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(7), CSF2(2), HLA-DRA(5), IL3(2), IL5(4)	466138	20	12	19	10	17	1	0	1	1	0	0.172	1.000	1.000
58	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(3), IFNGR2(2), JAK1(4), JAK2(6), STAT1(2)	1258167	19	11	19	6	8	0	1	6	4	0	0.499	1.000	1.000
59	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(3), BAX(1), BCL10(1), BCL2(2), BCL2L11(2), CASP8AP2(3), CASP9(2), CES1(11)	1674482	25	15	25	5	21	2	0	0	2	0	0.0324	1.000	1.000
60	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(3), AASDH(4), AASDHPPT(1), AASS(1), KARS(2)	1061593	11	9	11	4	9	0	0	1	1	0	0.496	1.000	1.000
61	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(5), CASP8(1), RIPK1(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(1)	1261204	13	11	13	4	9	1	1	1	1	0	0.189	1.000	1.000
62	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	IFNG(2), IFNGR1(3), IFNGR2(2), IKBKB(2), JAK2(6), LIN7A(10), NFKB1(1), NFKBIA(1), RB1(3), RELA(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TP53(20), USH1C(9), WT1(4)	2781809	68	37	65	19	32	3	4	12	15	2	0.0231	1.000	1.000
63	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(1), PAPSS2(2), SULT1E1(7), SULT2A1(4), SUOX(2)	942016	16	7	16	6	11	0	0	2	3	0	0.334	1.000	1.000
64	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(5), CDC25B(1), CDKN1A(1), CHEK1(1), NEK1(5)	1068460	13	10	13	4	8	1	1	1	2	0	0.410	1.000	1.000
65	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(2), ACAT2(1), EHHADH(5), HADHA(7), HADHB(2)	1289658	17	15	16	6	11	2	0	3	1	0	0.352	1.000	1.000
66	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(4), B3GNT1(1), FUT1(3), FUT2(1), FUT9(13)	918368	22	19	22	10	16	3	1	2	0	0	0.208	1.000	1.000
67	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(4), POLR2A(8), POLR2B(10), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2L(1), POLRMT(1)	2056161	29	23	29	9	18	3	1	4	3	0	0.0957	1.000	1.000
68	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	DAG1(3), GNAQ(1), ITPKB(4)	923493	8	8	8	4	6	0	1	0	1	0	0.467	1.000	1.000
69	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(2), SQLE(1)	657079	3	3	3	2	2	0	0	1	0	0	0.787	1.000	1.000
70	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(16), GNAS(12), PRKACA(2), PRKAR1A(1)	997641	31	20	31	10	21	2	2	3	3	0	0.0705	1.000	1.000
71	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(1), ERBB4(26), NRG2(4), NRG3(10), PRKCA(5)	1370159	46	33	44	15	34	3	2	4	3	0	0.0710	1.000	1.000
72	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLS2(3), GLUD1(1)	699968	5	3	5	5	3	1	0	0	1	0	0.884	1.000	1.000
73	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(3), ATM(8), BAX(1), BCL2(2), CCNE1(1), CDK4(2), CDKN1A(1), E2F1(5), MDM2(2), PCNA(1), RB1(3), TIMP3(3), TP53(20)	2771782	52	34	49	14	24	4	1	8	13	2	0.0755	1.000	1.000
74	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(4), BHMT(6), CBS(3), DNMT1(10), DNMT3A(5), DNMT3B(8), MARS(4), MARS2(3), MAT1A(4), MAT2B(1), MTR(5)	2720743	53	30	52	12	32	2	3	8	8	0	0.00304	1.000	1.000
75	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(3), BAX(1), BCL2(2), BIRC2(4), BIRC3(5), CASP7(3), CASP8(1), CASP9(2), CYCS(1), DFFA(1), DFFB(2), DIABLO(1)	2079623	26	19	26	7	15	3	4	3	1	0	0.0915	1.000	1.000
76	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(4), ICAM1(2), ITGAL(15), ITGAM(14), ITGB2(8), SELE(19), SELL(5)	1573432	67	31	67	23	56	2	1	2	6	0	0.00478	1.000	1.000
77	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(4), GNAQ(1), HTR2C(5), PLCB1(29), TUB(5)	1098691	44	28	43	18	38	0	0	3	3	0	0.0786	1.000	1.000
78	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(1), PSMB4(1), PSMB5(1), PSMB7(1), PSMC2(1), PSMC3(1), PSMD1(3), PSMD12(1), PSMD13(2), PSMD2(1)	2489995	22	19	21	7	13	2	2	3	2	0	0.252	1.000	1.000
79	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ASL(2), CPS1(12), GLS(1), GLUD1(1), GOT1(4)	1169207	20	11	20	8	14	2	2	2	0	0	0.307	1.000	1.000
80	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(4), CD3D(4), CD3E(2), GZMB(1), HLA-A(1), ICAM1(2), ITGAL(15), ITGB2(8), PRF1(5)	1337593	42	23	41	18	29	4	0	1	8	0	0.0781	1.000	1.000
81	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(1), BMPR1A(1), BMPR1B(2), BMPR2(3)	968453	7	7	7	6	6	0	0	0	1	0	0.872	1.000	1.000
82	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(1), PSMB4(1), PSMB5(1), PSMB7(1), PSMC3(1), PSMD14(1), RPN2(2), UBE3A(5)	2004824	22	18	22	9	13	3	1	3	2	0	0.434	1.000	1.000
83	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(2), ACP2(2), ACP5(2), ACP6(7), ACPP(4), ENPP1(7), ENPP3(8), FLAD1(6), LHPP(1), MTMR1(2), MTMR2(1), MTMR6(2), TYR(2)	2305297	46	29	45	14	28	2	5	4	7	0	0.0808	1.000	1.000
84	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(5), CHAT(10), CHKA(2), PCYT1A(2), PDHA1(1), PDHA2(7), PEMT(1), SLC18A3(2)	1059833	30	19	30	12	26	1	0	1	2	0	0.0748	1.000	1.000
85	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(3), APAF1(3), BCL2(2), CASP9(2), CYCS(1), DAXX(4), FAS(3), FASLG(10), HSPB1(1), HSPB2(1), IL1A(2), MAPKAPK2(2), MAPKAPK3(1), TNF(1)	1753277	36	24	36	12	26	2	0	1	7	0	0.0418	1.000	1.000
86	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(1), CS(1), FH(3), MDH1(1), OGDH(7), SDHA(1)	1461783	14	13	14	9	10	0	2	0	2	0	0.701	1.000	1.000
87	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(10), AOC2(5), AOC3(5), CES1(11), ESD(1)	926989	32	24	32	15	29	1	2	0	0	0	0.155	1.000	1.000
88	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(5), ST3GAL5(1), ST6GALNAC2(2)	875043	9	9	9	5	7	1	1	0	0	0	0.470	1.000	1.000
89	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(4), CLOCK(2), CRY1(3), CRY2(1), CSNK1E(3), PER1(2)	1297149	15	11	15	7	11	0	1	2	1	0	0.611	1.000	1.000
90	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(10), RANGAP1(2)	1314992	12	12	12	5	8	2	0	0	2	0	0.642	1.000	1.000
91	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(3), AASDHPPT(1), AASS(1), KARS(2)	714425	7	7	7	4	6	0	0	1	0	0	0.766	1.000	1.000
92	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP2(3), MMP9(5), RECK(3), TIMP2(1), TIMP3(3), TIMP4(2)	1144255	17	13	17	8	11	1	0	4	1	0	0.465	1.000	1.000
93	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(9), NR0B2(5), NR1H3(2), NR1H4(8), RXRA(1)	839763	25	15	25	10	17	4	2	0	2	0	0.107	1.000	1.000
94	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(5), FDPS(2), HMGCR(7), LSS(2), MVK(1), NQO1(1), PMVK(1), SQLE(1)	1694086	20	14	19	8	10	3	0	5	2	0	0.349	1.000	1.000
95	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2)	2035296	78	43	72	28	57	6	5	5	5	0	0.0103	1.000	1.000
96	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3D(4), CD3E(2), IFNG(2), IL2(4), IL2RA(4), IL4(1), TGFB2(1), TGFB3(1), TGFBR2(5), TGFBR3(4), TOB1(2), TOB2(2)	1618392	32	20	32	10	25	1	0	0	6	0	0.0441	1.000	1.000
97	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(3), CD8A(1), CSF1(7), CSF2(2), CSF3(1), EPO(4), IL11(2), IL2(4), IL3(2), IL4(1), IL5(4), IL7(3), IL8(1)	930400	35	19	34	19	26	3	0	2	4	0	0.178	1.000	1.000
98	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(3), ALAS2(2), CPOX(2), FECH(1), HMBS(1), PPOX(2), UROS(1)	1164342	12	10	12	5	10	1	0	0	1	0	0.337	1.000	1.000
99	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(1), CDC25A(5), CDC25B(1), CDC25C(3), MNAT1(2), SHH(2)	1345743	14	11	14	6	11	0	1	2	0	0	0.497	1.000	1.000
100	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(5), CS(1), MDH1(1), ME1(11), PC(5), PDHA1(1), SLC25A11(1)	1435147	25	15	25	12	16	3	1	3	2	0	0.299	1.000	1.000
101	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(4), PARK2(2), SNCAIP(28), UBE2E2(2), UBE2F(3), UBE2L6(1)	991685	40	25	35	14	31	5	0	3	1	0	0.128	1.000	1.000
102	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	11	ALAD(3), ALAS2(2), FECH(1), GATA1(1), HBB(5), HMBS(1), UROS(1)	1170845	14	11	13	9	12	1	0	0	1	0	0.562	1.000	1.000
103	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFB6(2), NDUFS2(1)	1079480	3	3	3	5	2	0	0	0	1	0	0.985	1.000	1.000
104	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(8), CYP2E1(8), NR1I3(5), PTGS1(12), PTGS2(6)	832500	39	23	39	20	30	1	0	3	5	0	0.204	1.000	1.000
105	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), FPGS(3), GGH(1), SPR(1)	977530	22	15	22	11	16	3	2	0	1	0	0.218	1.000	1.000
106	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(12), DAXX(4), PAX3(2), PML(1), RB1(3), SP100(5), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TP53(20)	2892451	51	31	49	17	24	5	4	5	11	2	0.131	1.000	1.000
107	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(3), CYSLTR2(2), GPR109B(7), GPR161(4), GPR171(4), GPR39(7), GPR45(4), GPR65(5), GPR68(2), GPR75(3), GPR81(3)	1504168	44	26	43	20	35	2	2	0	5	0	0.00520	1.000	1.000
108	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(3), ACSL1(2), ACSL3(3), CPT1A(6), CPT2(1), DCI(2), EHHADH(5), HADHA(7)	2614711	31	25	28	11	21	1	2	4	3	0	0.211	1.000	1.000
109	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(4), BHMT(6), CBS(3), DNMT1(10), DNMT3A(5), DNMT3B(8), MARS(4), MARS2(3), MAT1A(4), MAT2B(1), MTAP(3), MTFMT(1), MTR(5), TAT(10)	3231601	67	31	66	18	42	3	4	10	8	0	0.00398	1.000	1.000
110	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(3), ATM(8), ATR(13), CCNA1(7), CCNE1(1), CDC25A(5), CDK4(2), CDKN1A(1), CDKN2A(16), E2F1(5), GSK3B(1), HDAC1(1), RB1(3), TGFB2(1), TGFB3(1), TP53(20)	4645258	88	52	81	28	46	2	5	9	24	2	0.0424	1.000	1.000
111	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(13), CD3D(4), CD3E(2), CD8A(1), ICAM1(2), ITGAL(15), ITGB2(8), PTPRC(18)	1627399	63	30	58	28	51	2	0	3	7	0	0.0509	1.000	1.000
112	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(2), POLD2(1), POLE(9), POLG(4), POLL(6), POLQ(12)	2574099	34	28	34	14	17	3	2	6	6	0	0.253	1.000	1.000
113	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(2), ACP2(2), ACP5(2), ACPP(4), ENPP1(7), ENPP3(8), FLAD1(6), TYR(2)	1487033	33	23	32	12	21	1	2	3	6	0	0.232	1.000	1.000
114	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), ACO2(1), FH(3), IDH1(6), MDH1(1), MDH2(1)	1385559	13	11	10	9	9	0	2	1	1	0	0.740	1.000	1.000
115	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(4), ASPH(2), COPS5(2), EDN1(6), EP300(7), EPO(4), JUN(1), LDHA(2), NOS3(11), P4HB(2), VHL(1)	2633308	42	27	40	14	29	3	3	3	4	0	0.132	1.000	1.000
116	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(1), DNAJC3(1), EIF2S1(1), MAP3K14(1), NFKB1(1), NFKBIA(1), RELA(1), TP53(20)	1493907	27	22	25	10	15	0	2	3	7	0	0.395	1.000	1.000
117	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(1), APAF1(3), ATM(8), BAX(1), BCL2(2), CASP7(3), CASP9(2), CYCS(1), EIF2S1(1), PRKCA(5), PTK2(2), PXN(3), STAT1(2), TLN1(10), TP53(20)	4199433	64	37	61	21	34	7	3	9	11	0	0.0614	1.000	1.000
118	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT2(2), B4GALT3(1), B4GALT5(1), FUT8(4), ST3GAL1(5)	1211097	14	11	14	9	10	2	1	0	1	0	0.580	1.000	1.000
119	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(4), ICAM1(2), ITGA4(18), ITGAL(15), ITGB1(3), ITGB2(8), SELE(19), SELL(5)	1833668	74	36	72	24	60	2	2	4	6	0	0.0167	1.000	1.000
120	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(4), ICAM1(2), ITGA4(18), ITGAL(15), ITGAM(14), ITGB1(3), ITGB2(8), SELE(19), SELL(5), SELP(13)	2413126	101	43	97	35	84	2	2	6	7	0	0.00757	1.000	1.000
121	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(10), CKM(1), GPT(3), LDHA(2), LDHC(1), MAPK14(4), NCL(3)	1384104	24	15	24	11	16	2	2	3	1	0	0.378	1.000	1.000
122	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(5), CDO1(2), GOT1(4), GOT2(2), LDHA(2), LDHAL6B(5), LDHC(1), MPST(1), SULT1B1(8), SULT1C2(1), SULT1C4(9), SULT4A1(5)	1935061	45	27	44	17	34	1	5	0	5	0	0.0671	1.000	1.000
123	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(4), JAK2(6), JAK3(5), PIAS1(2), PIAS3(3), PTPRU(11), REG1A(4), SOAT1(1)	2096480	37	27	37	14	24	2	2	5	4	0	0.142	1.000	1.000
124	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(2), FUT1(3), FUT2(1), FUT9(13), GBGT1(1), HEXA(4), HEXB(2), ST3GAL1(5)	1552502	31	19	31	16	24	3	0	4	0	0	0.253	1.000	1.000
125	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(4), IFNG(2), IL10(1), IL12A(2), IL12B(3), IL13(2), IL15(1), IL16(7), IL18(2), IL1A(2), IL2(4), IL3(2), IL4(1), IL5(4), IL8(1), LTA(2), TNF(1)	1523010	41	21	40	18	31	3	0	1	6	0	0.0519	1.000	1.000
126	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(2), GSR(2), GSS(3), IL8(1), NFKB1(1), NOX1(6), RELA(1), TNF(1), XDH(33)	1516442	50	25	50	23	39	2	4	3	2	0	0.106	1.000	1.000
127	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(6), BCAT2(1), IARS(1), IARS2(9), ILVBL(2), LARS(8), LARS2(3), PDHA1(1), PDHA2(7), PDHB(1), VARS(10), VARS2(4)	2911298	53	31	49	19	38	6	1	4	4	0	0.103	1.000	1.000
128	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(4), B3GNT1(1), B3GNT2(2), B3GNT3(3), B3GNT4(2), B3GNT5(1), B4GALT2(2), B4GALT3(1), FUT1(3), FUT2(1), FUT3(3), FUT4(1), FUT5(6), FUT6(1), FUT7(1), FUT9(13), ST3GAL6(2)	2452451	47	31	47	22	31	8	2	2	4	0	0.118	1.000	1.000
129	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(14), FOS(1), JUN(1), MAP2K1(3), MAPK1(2), MAPK3(1), MYC(2), NFKB1(1), NFKBIA(1), PLCB1(29), PRKCA(5), RAF1(2), RELA(1), TNF(1)	2397083	64	38	61	28	50	3	4	3	4	0	0.0952	1.000	1.000
130	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(4), CARM1(2), CBS(3), GGT1(3), HEMK1(1), LCMT1(3), MARS(4), MARS2(3), MAT1A(4), MAT2B(1), METTL2B(5), PAPSS1(1), PAPSS2(2), PRMT2(1), PRMT3(3), PRMT5(3), PRMT6(1), PRMT7(1), PRMT8(7), SCLY(2), SEPHS1(3), SEPHS2(1)	3864336	58	33	57	22	36	5	3	8	6	0	0.0722	1.000	1.000
131	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(2), ACP2(2), ACP5(2), ACP6(7), ACPP(4), ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), CMBL(1), CYP3A4(12), CYP3A43(8), CYP3A5(4), CYP3A7(12), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(2), PON1(8), PON2(1), PON3(4)	2756209	94	41	93	36	69	5	6	6	8	0	0.00654	1.000	1.000
132	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNB1(4), JAK1(4), PTPRU(11), REG1A(4), STAT1(2), STAT2(5), TYK2(3)	1927731	33	22	33	14	20	2	1	5	5	0	0.181	1.000	1.000
133	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(3), CREBBP(12), DFFA(1), DFFB(2), GZMA(6), GZMB(1), PRF1(5), SET(2)	1636976	32	17	32	13	19	2	4	3	4	0	0.350	1.000	1.000
134	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(3), ACVR1C(7), AKT1(1), AKT2(6), AKT3(2), ARRB1(1), ARRB2(3), ATF2(5), ATF4(4), BDNF(2), BRAF(64), CACNA1A(19), CACNA1B(18), CACNA1C(27), CACNA1D(17), CACNA1E(62), CACNA1F(13), CACNA1G(19), CACNA1H(14), CACNA1I(20), CACNA1S(26), CACNA2D1(8), CACNA2D2(7), CACNA2D3(28), CACNA2D4(12), CACNB1(1), CACNB2(4), CACNB3(2), CACNB4(7), CACNG1(2), CACNG2(3), CACNG3(10), CACNG4(3), CACNG5(9), CACNG6(2), CACNG7(1), CD14(3), CDC25B(1), CHP(1), CHUK(1), CRK(2), DAXX(4), DDIT3(1), DUSP10(6), DUSP14(1), DUSP16(1), DUSP4(1), DUSP5(2), DUSP6(1), DUSP7(1), DUSP8(1), ECSIT(1), EGF(14), EGFR(13), ELK4(4), FAS(3), FASLG(10), FGF11(2), FGF12(8), FGF13(3), FGF14(4), FGF17(1), FGF18(2), FGF19(2), FGF21(1), FGF23(3), FGF3(4), FGF4(1), FGF5(2), FGF6(1), FGF7(6), FGF8(1), FGF9(1), FGFR1(6), FGFR2(20), FGFR3(7), FGFR4(5), FLNA(5), FLNB(23), FLNC(31), FOS(1), GADD45B(1), GNA12(2), GRB2(2), IKBKB(2), IL1A(2), IL1B(2), IL1R1(6), IL1R2(5), JUN(1), KRAS(1), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAP2K5(2), MAP2K6(2), MAP2K7(2), MAP3K10(5), MAP3K12(2), MAP3K13(5), MAP3K14(1), MAP3K2(2), MAP3K3(3), MAP3K4(9), MAP3K5(9), MAP3K6(5), MAP4K1(3), MAP4K2(4), MAP4K3(4), MAP4K4(5), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(2), MAPK14(4), MAPK3(1), MAPK7(2), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1), MAPKAPK2(2), MAPKAPK3(1), MAPT(4), MEF2C(2), MKNK1(5), MKNK2(2), MOS(5), MYC(2), NF1(20), NFATC2(4), NFATC4(3), NFKB1(1), NFKB2(3), NLK(2), NR4A1(1), NRAS(29), NTF3(3), NTRK1(9), NTRK2(6), PAK1(2), PAK2(2), PDGFA(1), PDGFB(1), PDGFRA(13), PDGFRB(7), PLA2G12B(3), PLA2G2A(1), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(12), PLA2G4A(7), PLA2G6(7), PPM1A(1), PPM1B(5), PPP3CA(4), PPP3CB(1), PPP3R2(5), PPP5C(2), PRKACA(2), PRKACB(2), PRKACG(5), PRKCA(5), PRKCG(9), PRKX(1), PTPN5(7), PTPN7(1), PTPRR(18), RAC1(7), RAF1(2), RAP1A(1), RAPGEF2(6), RASA1(1), RASA2(9), RASGRF1(14), RASGRF2(6), RASGRP1(6), RASGRP2(2), RASGRP3(7), RASGRP4(7), RPS6KA1(2), RPS6KA2(4), RPS6KA4(2), RPS6KA5(3), RPS6KA6(3), RRAS(1), SOS1(4), SOS2(3), SRF(1), STK4(3), STMN1(1), TAOK1(8), TAOK2(18), TGFB2(1), TGFB3(1), TGFBR2(5), TNF(1), TNFRSF1A(2), TP53(20), TRAF2(1), TRAF6(2), ZAK(4)	43212047	1167	103	1060	607	766	100	39	159	101	2	0.0121	1.000	1.000
135	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ACTN1(2), ACTN2(14), ACTN3(5), ACTN4(2), APC(11), APC2(4), ARHGEF1(1), ARHGEF12(6), ARHGEF4(3), ARHGEF6(5), ARHGEF7(2), ARPC1B(1), ARPC2(1), ARPC3(1), BAIAP2(2), BCAR1(3), BDKRB1(4), BDKRB2(2), BRAF(64), CD14(3), CHRM1(4), CHRM2(7), CHRM3(10), CHRM4(4), CHRM5(1), CRK(2), CSK(1), CYFIP1(2), CYFIP2(15), DIAPH1(4), DIAPH2(2), DIAPH3(4), DOCK1(11), EGF(14), EGFR(13), EZR(1), F2(6), F2R(3), FGD1(2), FGD3(3), FGF11(2), FGF12(8), FGF13(3), FGF14(4), FGF17(1), FGF18(2), FGF19(2), FGF21(1), FGF23(3), FGF3(4), FGF4(1), FGF5(2), FGF6(1), FGF7(6), FGF8(1), FGF9(1), FGFR1(6), FGFR2(20), FGFR3(7), FGFR4(5), FN1(8), GIT1(4), GNA12(2), GNA13(1), GRLF1(3), GSN(3), IQGAP1(7), IQGAP2(13), IQGAP3(7), ITGA1(14), ITGA10(2), ITGA11(12), ITGA2(7), ITGA2B(6), ITGA3(4), ITGA4(18), ITGA5(11), ITGA6(5), ITGA7(15), ITGA8(22), ITGA9(9), ITGAD(16), ITGAE(8), ITGAL(15), ITGAM(14), ITGAV(4), ITGAX(10), ITGB1(3), ITGB2(8), ITGB3(7), ITGB4(11), ITGB6(8), ITGB7(3), ITGB8(9), KRAS(1), LIMK1(4), LIMK2(5), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK3(1), MOS(5), MYH10(5), MYH14(10), MYH9(6), MYL2(4), MYL9(1), MYLK(17), MYLK2(4), MYLPF(1), NCKAP1(1), NCKAP1L(20), NRAS(29), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PAK7(27), PDGFA(1), PDGFB(1), PDGFRA(13), PDGFRB(7), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PIP4K2A(3), PIP4K2B(2), PIP4K2C(1), PIP5K1A(6), PIP5K1B(11), PIP5K1C(4), PPP1CA(1), PPP1CB(3), PPP1CC(1), PPP1R12A(2), PPP1R12B(5), PTK2(2), PXN(3), RAC1(7), RAF1(2), ROCK1(2), ROCK2(4), RRAS(1), SCIN(3), SLC9A1(1), SOS1(4), SOS2(3), SSH1(8), SSH2(4), SSH3(3), TIAM1(20), TIAM2(17), TMSL3(2), VAV1(12), VAV2(3), VAV3(5), VCL(4), WAS(4), WASF1(1), WASF2(4), WASL(1)	42118470	993	101	898	481	676	54	41	155	64	3	0.00116	1.000	1.000
136	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(3), ACTG1(3), ACTN1(2), ACTN2(14), ACTN3(5), ACTN4(2), AKT1(1), AKT2(6), AKT3(2), ARHGAP5(7), BCAR1(3), BCL2(2), BIRC2(4), BIRC3(5), BRAF(64), CAPN2(2), CAV1(1), CCND2(3), CHAD(3), COL11A1(34), COL11A2(25), COL1A1(25), COL1A2(24), COL2A1(17), COL3A1(34), COL4A1(29), COL4A2(20), COL4A4(50), COL4A6(21), COL5A1(34), COL5A2(22), COL5A3(40), COL6A1(7), COL6A2(6), COL6A3(32), COL6A6(29), COMP(4), CRK(2), CTNNB1(5), DIAPH1(4), DOCK1(11), EGF(14), EGFR(13), ERBB2(2), FARP2(2), FIGF(4), FLNA(5), FLNB(23), FLNC(31), FLT1(17), FN1(8), FYN(4), GRB2(2), GRLF1(3), GSK3B(1), HGF(8), IBSP(4), IGF1(6), IGF1R(5), ITGA1(14), ITGA10(2), ITGA11(12), ITGA2(7), ITGA2B(6), ITGA3(4), ITGA4(18), ITGA5(11), ITGA6(5), ITGA7(15), ITGA8(22), ITGA9(9), ITGAV(4), ITGB1(3), ITGB3(7), ITGB4(11), ITGB6(8), ITGB7(3), ITGB8(9), JUN(1), KDR(22), LAMA1(21), LAMA2(24), LAMA3(31), LAMA4(4), LAMA5(17), LAMB1(6), LAMB2(5), LAMB3(17), LAMB4(20), LAMC1(8), LAMC2(10), LAMC3(6), MAP2K1(3), MAPK1(2), MAPK10(5), MAPK3(1), MAPK9(1), MET(7), MYL2(4), MYL9(1), MYLK(17), MYLK2(4), MYLPF(1), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PAK7(27), PARVA(1), PARVB(1), PARVG(1), PDGFA(1), PDGFB(1), PDGFC(12), PDGFD(2), PDGFRA(13), PDGFRB(7), PDPK1(1), PGF(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PIP5K1C(4), PPP1CA(1), PPP1CB(3), PPP1CC(1), PPP1R12A(2), PRKCA(5), PRKCG(9), PTEN(11), PTK2(2), PXN(3), RAC1(7), RAF1(2), RAP1A(1), RAPGEF1(3), RELN(42), ROCK1(2), ROCK2(4), SHC2(4), SHC3(7), SOS1(4), SOS2(3), SPP1(3), THBS1(15), THBS2(5), THBS3(7), THBS4(7), TLN1(10), TLN2(10), TNC(16), TNN(27), TNR(44), TNXB(65), VAV1(12), VAV2(3), VAV3(5), VCL(4), VEGFA(1), VEGFB(1), VEGFC(13), VTN(5), VWF(28), ZYX(3)	56940012	1689	99	1599	756	1257	105	47	173	105	2	0.000239	1.000	1.000
137	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(64), C7orf16(1), CACNA1A(19), CRH(2), CRHR1(1), GNA11(2), GNA12(2), GNA13(1), GNAI2(2), GNAO1(1), GNAQ(1), GNAS(12), GNAZ(3), GRIA1(28), GRIA2(19), GRIA3(15), GRID2(31), GRM1(7), GRM5(5), GUCY1A2(8), GUCY1A3(18), GUCY1B3(4), GUCY2C(16), GUCY2D(3), GUCY2F(7), IGF1(6), IGF1R(5), ITPR1(16), ITPR2(10), ITPR3(4), KRAS(1), LYN(1), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK3(1), NOS1(32), NOS3(11), NPR1(12), NPR2(11), NRAS(29), PLA2G12B(3), PLA2G2A(1), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(12), PLA2G4A(7), PLA2G6(7), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(2), PPP2R2C(4), PRKCA(5), PRKCG(9), PRKG1(5), PRKG2(8), RAF1(2), RYR1(52)	16712661	619	99	518	314	419	34	22	107	37	0	0.00469	1.000	1.000
138	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	BRAF(64), CD244(6), CD247(1), CD48(4), CHP(1), CSF2(2), FAS(3), FASLG(10), FCER1G(1), FCGR3A(3), FYN(4), GRB2(2), GZMB(1), HLA-A(1), HLA-B(4), HLA-C(1), HLA-G(3), ICAM1(2), ICAM2(4), IFNA10(1), IFNA14(4), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(6), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR2(3), IFNB1(4), IFNG(2), IFNGR1(3), IFNGR2(2), ITGAL(15), ITGB2(8), KIR2DL1(12), KIR2DL3(4), KIR2DL4(3), KIR3DL1(14), KIR3DL2(2), KLRC1(2), KLRC2(1), KLRC3(5), KLRD1(4), KLRK1(3), KRAS(1), LCK(4), LCP2(5), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK3(1), MICA(3), MICB(2), NCR1(8), NCR2(4), NCR3(2), NFAT5(3), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), NRAS(29), PAK1(2), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PLCG1(4), PLCG2(9), PPP3CA(4), PPP3CB(1), PPP3R2(5), PRF1(5), PRKCA(5), PRKCG(9), PTK2B(7), PTPN11(3), PTPN6(1), RAC1(7), RAF1(2), SH2D1A(2), SH2D1B(3), SH3BP2(2), SHC2(4), SHC3(7), SOS1(4), SOS2(3), SYK(9), TNF(1), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10C(3), TNFRSF10D(4), TNFSF10(5), TYROBP(2), ULBP1(2), ULBP3(3), VAV1(12), VAV2(3), VAV3(5), ZAP70(4)	17312069	502	98	417	207	321	31	23	102	25	0	0.00121	1.000	1.000
139	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(16), ADCY8(26), ATF4(4), BRAF(64), CACNA1C(27), CALM2(1), CALML3(3), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CAMK4(8), CHP(1), CREBBP(12), EP300(7), GNAQ(1), GRIA1(28), GRIA2(19), GRIN1(6), GRIN2A(48), GRIN2B(28), GRIN2C(6), GRIN2D(3), GRM1(7), GRM5(5), ITPR1(16), ITPR2(10), ITPR3(4), KRAS(1), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK3(1), NRAS(29), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), PPP1CA(1), PPP1CB(3), PPP1CC(1), PPP1R12A(2), PPP1R1A(2), PPP3CA(4), PPP3CB(1), PPP3R2(5), PRKACA(2), PRKACB(2), PRKACG(5), PRKCA(5), PRKCG(9), PRKX(1), RAF1(2), RAP1A(1), RAPGEF3(4), RPS6KA1(2), RPS6KA2(4), RPS6KA6(3)	15060467	525	98	436	267	334	37	22	103	29	0	0.0499	1.000	1.000
140	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(3), ABL2(6), AKT1(1), AKT2(6), AKT3(2), AREG(6), BRAF(64), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CBL(4), CBLB(7), CBLC(12), CDKN1A(1), CRK(2), EGF(14), EGFR(13), ERBB2(2), ERBB3(2), ERBB4(26), GAB1(3), GRB2(2), GSK3B(1), JUN(1), KRAS(1), MAP2K1(3), MAP2K2(2), MAP2K4(3), MAP2K7(2), MAPK1(2), MAPK10(5), MAPK3(1), MAPK9(1), MYC(2), NCK2(3), NRAS(29), NRG1(9), NRG2(4), NRG3(10), NRG4(1), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PAK7(27), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PLCG1(4), PLCG2(9), PRKCA(5), PRKCG(9), PTK2(2), RAF1(2), RPS6KB1(1), RPS6KB2(2), SHC2(4), SHC3(7), SOS1(4), SOS2(3), STAT5A(2), STAT5B(2), TGFA(1)	15726704	401	97	317	154	233	19	26	108	15	0	0.0108	1.000	1.000
141	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(12), ADORA1(1), ADORA2A(1), ADORA2B(1), ADORA3(10), ADRA1A(4), ADRA1B(1), ADRA2A(2), ADRA2B(4), ADRA2C(2), ADRB1(3), ADRB2(1), AGTR1(6), AGTR2(2), AVPR1A(2), AVPR1B(5), BDKRB1(4), BDKRB2(2), BRS3(2), C3AR1(2), C5AR1(4), CALCR(11), CALCRL(8), CCKAR(8), CCKBR(8), CHRM1(4), CHRM2(7), CHRM3(10), CHRM4(4), CHRM5(1), CNR1(7), CNR2(1), CRHR1(1), CRHR2(1), CTSG(4), CYSLTR1(3), CYSLTR2(2), DRD1(7), DRD2(8), DRD3(1), DRD4(1), DRD5(16), EDNRA(3), EDNRB(3), F2(6), F2R(3), F2RL1(7), F2RL2(3), FPR1(15), FSHB(2), FSHR(9), GABBR1(4), GABBR2(8), GABRA1(7), GABRA2(8), GABRA3(12), GABRA4(6), GABRA5(2), GABRA6(15), GABRB1(9), GABRB2(6), GABRB3(12), GABRD(4), GABRE(9), GABRG1(13), GABRG2(6), GABRG3(4), GABRP(8), GABRQ(3), GABRR1(4), GALR1(3), GH1(1), GH2(7), GHR(14), GHRHR(4), GHSR(5), GIPR(2), GLP1R(5), GLP2R(5), GLRA1(7), GLRA2(4), GLRA3(6), GLRB(11), GNRHR(2), GPR156(4), GPR35(2), GPR50(8), GPR63(4), GPR83(6), GRIA1(28), GRIA2(19), GRIA3(15), GRIA4(13), GRID1(12), GRID2(31), GRIK1(10), GRIK2(13), GRIK3(16), GRIK4(6), GRIK5(8), GRIN1(6), GRIN2A(48), GRIN2B(28), GRIN2C(6), GRIN2D(3), GRIN3A(23), GRIN3B(2), GRM1(7), GRM2(1), GRM3(30), GRM4(13), GRM5(5), GRM6(14), GRM7(18), GRM8(26), GRPR(2), GZMA(6), HCRTR2(15), HRH1(9), HRH2(3), HRH3(3), HRH4(4), HTR1A(6), HTR1D(2), HTR1E(3), HTR1F(5), HTR2A(6), HTR2C(5), HTR4(4), HTR5A(10), HTR6(1), HTR7(4), LEP(1), LEPR(10), LHCGR(10), MAS1(1), MC2R(2), MC3R(6), MC4R(1), MC5R(4), MCHR1(2), MCHR2(6), MLNR(1), MTNR1A(6), MTNR1B(5), NMBR(2), NMUR1(2), NMUR2(9), NPBWR1(1), NPBWR2(6), NPFFR2(6), NPY1R(10), NPY2R(8), NPY5R(11), NR3C1(1), NTSR1(3), NTSR2(1), OPRK1(14), OPRL1(3), OPRM1(4), OXTR(3), P2RX1(2), P2RX2(1), P2RX3(3), P2RX4(1), P2RX5(4), P2RX7(3), P2RY1(1), P2RY10(6), P2RY13(2), P2RY14(5), P2RY2(3), P2RY6(1), P2RY8(3), PARD3(9), PPYR1(9), PRL(1), PRLHR(1), PRLR(17), PRSS1(10), PRSS3(2), PTGDR(7), PTGER2(4), PTGER3(1), PTGFR(12), PTGIR(3), PTH2R(8), RXFP1(10), RXFP2(9), SCTR(3), SSTR1(5), SSTR2(1), SSTR3(9), SSTR4(1), SSTR5(2), TAAR1(2), TAAR2(8), TAAR5(1), TAAR6(3), TAAR8(3), TAAR9(1), TACR1(3), TACR2(3), TACR3(16), TBXA2R(3), THRA(1), THRB(10), TRHR(9), TRPV1(1), TSHB(2), TSHR(6), UTS2R(1), VIPR1(3), VIPR2(3)	33655818	1341	97	1298	861	997	103	37	99	105	0	1.95e-05	1.000	1.000
142	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(12), ACACB(12), AKT1(1), AKT2(6), AKT3(2), BRAF(64), CALM2(1), CALML3(3), CBL(4), CBLB(7), CBLC(12), CRK(2), EXOC7(5), FASN(9), FBP1(1), FLOT1(1), FOXO1(4), G6PC(4), G6PC2(2), GCK(8), GRB2(2), GSK3B(1), GYS1(2), GYS2(10), IKBKB(2), INPP5D(19), INSR(11), IRS1(2), IRS4(5), KRAS(1), LIPE(5), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK10(5), MAPK3(1), MAPK9(1), MKNK1(5), MKNK2(2), NRAS(29), PCK1(15), PCK2(2), PDE3A(13), PDE3B(3), PDPK1(1), PFKL(2), PHKA1(8), PHKA2(5), PHKB(3), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PKLR(6), PKM2(4), PPARGC1A(14), PPP1CA(1), PPP1CB(3), PPP1CC(1), PPP1R3A(29), PPP1R3B(2), PPP1R3C(2), PPP1R3D(1), PRKAA1(1), PRKAA2(15), PRKAB2(1), PRKACA(2), PRKACB(2), PRKACG(5), PRKAG1(1), PRKAG2(2), PRKAG3(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKCI(4), PRKCZ(1), PRKX(1), PTPN1(1), PTPRF(15), PYGB(2), PYGL(2), PYGM(6), RAF1(2), RAPGEF1(3), RPS6(1), RPS6KB1(1), RPS6KB2(2), SH2B2(3), SHC2(4), SHC3(7), SLC2A4(2), SOCS3(2), SOCS4(2), SORBS1(6), SOS1(4), SOS2(3), SREBF1(2), TRIP10(2), TSC1(3), TSC2(6)	24499465	548	97	464	234	349	33	26	108	32	0	0.00170	1.000	1.000
143	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(16), ADCY2(6), ADCY3(2), ADCY4(1), ADCY7(6), ADCY8(26), ADCY9(9), ADORA2A(1), ADORA2B(1), ADRA1A(4), ADRA1B(1), ADRA1D(3), ADRB1(3), ADRB2(1), AGTR1(6), ATP2A1(2), ATP2A2(3), ATP2A3(6), ATP2B1(3), ATP2B2(9), ATP2B3(5), ATP2B4(7), AVPR1A(2), AVPR1B(5), BDKRB1(4), BDKRB2(2), CACNA1A(19), CACNA1B(18), CACNA1C(27), CACNA1D(17), CACNA1E(62), CACNA1F(13), CACNA1G(19), CACNA1H(14), CACNA1I(20), CACNA1S(26), CALM2(1), CALML3(3), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CAMK4(8), CCKAR(8), CCKBR(8), CD38(3), CHP(1), CHRM1(4), CHRM2(7), CHRM3(10), CHRM5(1), CHRNA7(2), CYSLTR1(3), CYSLTR2(2), DRD1(7), EDNRA(3), EDNRB(3), EGFR(13), ERBB2(2), ERBB3(2), ERBB4(26), F2R(3), GNA11(2), GNA14(3), GNA15(2), GNAL(2), GNAQ(1), GNAS(12), GRIN1(6), GRIN2A(48), GRIN2C(6), GRIN2D(3), GRM1(7), GRM5(5), GRPR(2), HRH1(9), HRH2(3), HTR2A(6), HTR2C(5), HTR4(4), HTR5A(10), HTR6(1), HTR7(4), ITPKB(4), ITPR1(16), ITPR2(10), ITPR3(4), LHCGR(10), MYLK(17), MYLK2(4), NOS1(32), NOS3(11), NTSR1(3), OXTR(3), P2RX1(2), P2RX2(1), P2RX3(3), P2RX4(1), P2RX5(4), P2RX7(3), PDE1A(21), PDE1B(6), PDE1C(23), PDGFRA(13), PDGFRB(7), PHKA1(8), PHKA2(5), PHKB(3), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), PLCD1(2), PLCD3(1), PLCD4(1), PLCE1(22), PLCG1(4), PLCG2(9), PLCZ1(8), PPP3CA(4), PPP3CB(1), PPP3R2(5), PRKACA(2), PRKACB(2), PRKACG(5), PRKCA(5), PRKCG(9), PRKX(1), PTGER3(1), PTGFR(12), PTK2B(7), RYR1(52), RYR2(42), RYR3(42), SLC25A6(2), SLC8A1(13), SLC8A2(3), SLC8A3(16), SPHK1(1), SPHK2(5), TACR1(3), TACR2(3), TACR3(16), TBXA2R(3), TNNC2(2), TRHR(9), TRPC1(3), VDAC1(1), VDAC2(1), VDAC3(1)	40735960	1241	95	1202	852	917	85	42	93	101	3	0.199	1.000	1.000
144	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(6), CD36(3), CD44(4), CD47(1), CHAD(3), COL11A1(34), COL11A2(25), COL1A1(25), COL1A2(24), COL2A1(17), COL3A1(34), COL4A1(29), COL4A2(20), COL4A4(50), COL4A6(21), COL5A1(34), COL5A2(22), COL5A3(40), COL6A1(7), COL6A2(6), COL6A3(32), COL6A6(29), DAG1(3), FN1(8), FNDC1(23), FNDC3A(7), FNDC4(5), FNDC5(1), GP5(2), GP6(4), GP9(4), HMMR(4), HSPG2(15), IBSP(4), ITGA1(14), ITGA10(2), ITGA11(12), ITGA2(7), ITGA2B(6), ITGA3(4), ITGA4(18), ITGA5(11), ITGA6(5), ITGA7(15), ITGA8(22), ITGA9(9), ITGAV(4), ITGB1(3), ITGB3(7), ITGB4(11), ITGB6(8), ITGB7(3), ITGB8(9), LAMA1(21), LAMA2(24), LAMA3(31), LAMA4(4), LAMA5(17), LAMB1(6), LAMB2(5), LAMB3(17), LAMB4(20), LAMC1(8), LAMC2(10), LAMC3(6), RELN(42), SDC1(1), SDC2(1), SDC3(3), SDC4(2), SPP1(3), SV2A(13), SV2B(20), SV2C(6), THBS1(15), THBS2(5), THBS3(7), THBS4(7), TNC(16), TNN(27), TNR(44), TNXB(65), VTN(5), VWF(28)	34392960	1195	95	1170	540	937	68	39	78	72	1	0.0449	1.000	1.000
145	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(3), ACTG1(3), CHAD(3), COL11A1(34), COL11A2(25), COL17A1(14), COL1A1(25), COL1A2(24), COL2A1(17), COL3A1(34), COL4A1(29), COL4A2(20), COL4A4(50), COL4A6(21), COL5A1(34), COL5A2(22), COL5A3(40), COL6A1(7), COL6A2(6), COL6A3(32), COL6A6(29), COMP(4), DES(4), DSC1(23), DSC2(26), DSC3(19), DSG1(32), DSG2(15), DSG3(29), DSG4(33), FN1(8), GJA1(4), GJA10(9), GJA3(1), GJA4(3), GJA5(4), GJA8(10), GJA9(3), GJB2(3), GJB3(1), GJB4(5), GJB5(2), GJB6(4), GJB7(1), GJC1(4), GJC3(1), IBSP(4), INA(3), ITGA6(5), ITGB4(11), KRT1(11), KRT10(7), KRT12(8), KRT13(5), KRT14(1), KRT15(2), KRT16(4), KRT17(7), KRT18(2), KRT2(9), KRT20(4), KRT23(3), KRT24(4), KRT25(7), KRT27(2), KRT28(4), KRT3(6), KRT31(2), KRT32(8), KRT33A(2), KRT33B(2), KRT34(7), KRT35(6), KRT36(11), KRT37(4), KRT38(4), KRT39(8), KRT4(7), KRT40(3), KRT5(8), KRT6A(9), KRT6B(1), KRT6C(6), KRT7(3), KRT71(8), KRT72(4), KRT73(6), KRT74(6), KRT75(10), KRT76(8), KRT77(10), KRT78(12), KRT79(6), KRT8(1), KRT81(3), KRT82(5), KRT83(7), KRT84(3), KRT85(1), KRT86(6), KRT9(9), LAMA1(21), LAMA2(24), LAMA3(31), LAMA4(4), LAMA5(17), LAMB1(6), LAMB2(5), LAMB3(17), LAMB4(20), LAMC1(8), LAMC2(10), LAMC3(6), LMNA(3), LMNB2(4), NES(13), RELN(42), SPP1(3), THBS1(15), THBS2(5), THBS3(7), THBS4(7), TNC(16), TNN(27), TNR(44), TNXB(65), VIM(3), VTN(5), VWF(28)	38366653	1481	94	1443	658	1168	104	29	88	91	1	1.40e-05	1.000	1.000
146	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1(1), ACVR1B(3), ACVR2A(1), ACVR2B(1), AMHR2(7), BMP2(3), BMP7(2), BMPR1A(1), BMPR1B(2), BMPR2(3), CCL14(2), CCL15(2), CCL16(1), CCL21(1), CCL24(1), CCL25(1), CCL28(1), CCL7(3), CCL8(2), CCR1(5), CCR2(6), CCR3(7), CCR4(4), CCR5(4), CCR6(1), CCR7(2), CCR8(2), CCR9(2), CD27(2), CD40(1), CD40LG(1), CLCF1(1), CNTFR(3), CSF1(7), CSF1R(6), CSF2(2), CSF2RA(8), CSF2RB(8), CSF3(1), CSF3R(5), CX3CL1(2), CX3CR1(9), CXCL10(2), CXCL11(1), CXCL12(1), CXCL14(1), CXCL3(1), CXCL5(2), CXCL9(2), CXCR3(2), CXCR6(4), EDA2R(3), EDAR(3), EGF(14), EGFR(13), EPO(4), EPOR(1), FAS(3), FASLG(10), FLT1(17), FLT3(18), FLT3LG(1), FLT4(16), GDF5(8), GH1(1), GH2(7), GHR(14), HGF(8), IFNA10(1), IFNA14(4), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(6), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR2(3), IFNB1(4), IFNG(2), IFNGR1(3), IFNGR2(2), IFNK(1), IFNW1(4), IL10(1), IL10RA(4), IL10RB(2), IL11(2), IL11RA(1), IL12A(2), IL12B(3), IL12RB1(8), IL12RB2(3), IL13(2), IL13RA1(2), IL15(1), IL15RA(3), IL17A(6), IL17RA(3), IL18(2), IL18R1(13), IL18RAP(13), IL19(2), IL1A(2), IL1B(2), IL1R1(6), IL1R2(5), IL1RAP(2), IL2(4), IL20(2), IL20RA(7), IL21(2), IL21R(10), IL22(1), IL22RA1(5), IL22RA2(1), IL23A(1), IL23R(1), IL25(1), IL26(2), IL28A(1), IL28B(2), IL28RA(4), IL29(1), IL2RA(4), IL2RB(6), IL2RG(2), IL3(2), IL3RA(4), IL4(1), IL4R(5), IL5(4), IL5RA(7), IL6R(2), IL6ST(4), IL7(3), IL7R(15), IL8(1), IL9R(4), INHBA(10), INHBB(4), INHBC(6), INHBE(1), KDR(22), KIT(7), KITLG(6), LEP(1), LEPR(10), LIF(1), LIFR(13), LTA(2), LTB(1), MET(7), MPL(1), NGFR(6), OSM(2), OSMR(26), PDGFB(1), PDGFC(12), PDGFRA(13), PDGFRB(7), PLEKHO2(5), PPBP(3), PRL(1), PRLR(17), RELT(1), TGFB2(1), TGFB3(1), TGFBR2(5), TNF(1), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10C(3), TNFRSF10D(4), TNFRSF11A(3), TNFRSF11B(8), TNFRSF13B(6), TNFRSF14(2), TNFRSF17(3), TNFRSF18(3), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(6), TNFRSF25(3), TNFRSF4(4), TNFRSF6B(1), TNFRSF8(9), TNFRSF9(2), TNFSF10(5), TNFSF11(3), TNFSF14(6), TNFSF15(6), TNFSF18(3), TNFSF4(3), TNFSF8(2), TNFSF9(1), TPO(28), TSLP(1), VEGFA(1), VEGFB(1), VEGFC(13), XCL1(1), XCL2(1), XCR1(1)	27102537	862	94	840	483	656	58	15	50	83	0	0.0554	1.000	1.000
147	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(64), CPEB1(5), EGFR(13), ERBB2(2), ERBB4(26), ETS1(3), ETS2(7), ETV6(8), ETV7(2), FMN2(40), GRB2(2), KRAS(1), MAP2K1(3), MAPK1(2), MAPK3(1), NOTCH1(3), NOTCH2(22), NOTCH3(14), NOTCH4(35), PIWIL1(14), PIWIL2(7), PIWIL3(10), PIWIL4(2), RAF1(2), SOS1(4), SOS2(3), SPIRE2(2)	8058591	297	94	242	103	175	17	7	85	13	0	0.0124	1.000	1.000
148	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(1), AKT2(6), AKT3(2), CBL(4), CBLB(7), CBLC(12), CCND2(3), CISH(1), CLCF1(1), CNTFR(3), CREBBP(12), CSF2(2), CSF2RA(8), CSF2RB(8), CSF3(1), CSF3R(5), EP300(7), EPO(4), EPOR(1), GH1(1), GH2(7), GHR(14), GRB2(2), IFNA10(1), IFNA14(4), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(6), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR2(3), IFNB1(4), IFNG(2), IFNGR1(3), IFNGR2(2), IFNK(1), IFNW1(4), IL10(1), IL10RA(4), IL10RB(2), IL11(2), IL11RA(1), IL12A(2), IL12B(3), IL12RB1(8), IL12RB2(3), IL13(2), IL13RA1(2), IL13RA2(1), IL15(1), IL15RA(3), IL19(2), IL2(4), IL20(2), IL20RA(7), IL21(2), IL21R(10), IL22(1), IL22RA1(5), IL22RA2(1), IL23A(1), IL23R(1), IL26(2), IL28A(1), IL28B(2), IL28RA(4), IL29(1), IL2RA(4), IL2RB(6), IL2RG(2), IL3(2), IL3RA(4), IL4(1), IL4R(5), IL5(4), IL5RA(7), IL6R(2), IL6ST(4), IL7(3), IL7R(15), IL9R(4), IRF9(1), JAK1(4), JAK2(6), JAK3(5), LEP(1), LEPR(10), LIF(1), LIFR(13), MPL(1), MYC(2), OSM(2), OSMR(26), PIAS1(2), PIAS2(4), PIAS3(3), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PIM1(1), PRL(1), PRLR(17), PTPN11(3), PTPN6(1), SOCS3(2), SOCS4(2), SOCS5(3), SOCS7(3), SOS1(4), SOS2(3), SPRED1(3), SPRED2(1), SPRY1(6), SPRY2(3), SPRY3(6), SPRY4(1), STAM(2), STAT1(2), STAT2(5), STAT3(6), STAT4(12), STAT5A(2), STAT5B(2), STAT6(2), TPO(28), TSLP(1), TYK2(3)	22337778	543	91	532	269	393	41	16	47	46	0	0.101	1.000	1.000
149	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(3), ACTN1(2), ACTR2(2), AKT1(1), AKT2(6), AKT3(2), ANGPTL2(2), ARHGEF6(5), ARHGEF7(2), BCAR1(3), BRAF(64), CAV1(1), CDKN2A(16), CRK(2), CSE1L(4), DOCK1(11), EPHB2(15), FYN(4), GRB2(2), GRB7(5), GRLF1(3), ITGA1(14), ITGA10(2), ITGA11(12), ITGA2(7), ITGA3(4), ITGA4(18), ITGA5(11), ITGA6(5), ITGA7(15), ITGA8(22), ITGA9(9), MAP2K4(3), MAP2K7(2), MAP3K11(3), MAPK1(2), MAPK10(5), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1), MYLK(17), MYLK2(4), P4HB(2), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PAK7(27), PIK3CA(2), PIK3CB(10), PKLR(6), PLCG1(4), PLCG2(9), PTEN(11), PTK2(2), RAF1(2), RHO(2), ROCK1(2), ROCK2(4), SOS1(4), SOS2(3), TLN1(10), TLN2(10), WAS(4), ZYX(3)	18665182	453	91	391	188	274	26	18	97	38	0	0.00524	1.000	1.000
150	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(3), ACTA2(3), ACTN2(14), ACTN3(5), ACTN4(2), DES(4), DMD(14), MYBPC1(12), MYBPC2(5), MYBPC3(6), MYH3(12), MYH6(15), MYH7(27), MYH8(28), MYL1(8), MYL2(4), MYL3(2), MYL4(5), MYL9(1), MYOM1(12), NEB(65), TCAP(1), TNNC2(2), TNNI1(1), TNNI3(1), TNNT1(2), TNNT2(2), TNNT3(3), TPM2(2), TPM3(2), TPM4(1), TTN(589), VIM(3)	20216259	856	90	819	354	650	61	29	67	41	8	3.67e-06	1.000	1.000
151	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(3), ABLIM1(7), ABLIM2(2), ABLIM3(4), ARHGEF12(6), CDK5(3), CHP(1), CXCL12(1), DCC(40), DPYSL2(4), DPYSL5(8), EFNA4(1), EFNA5(2), EFNB1(1), EFNB3(1), EPHA1(5), EPHA2(7), EPHA3(10), EPHA4(9), EPHA5(5), EPHA6(34), EPHA7(23), EPHA8(8), EPHB1(13), EPHB2(15), EPHB3(8), EPHB4(2), EPHB6(9), FES(4), FYN(4), GNAI2(2), GSK3B(1), ITGB1(3), KRAS(1), L1CAM(3), LIMK1(4), LIMK2(5), LRRC4C(19), MAPK1(2), MAPK3(1), MET(7), NCK2(3), NFAT5(3), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), NGEF(7), NRAS(29), NRP1(11), NTN4(10), NTNG1(6), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PAK7(27), PLXNA1(5), PLXNA2(6), PLXNA3(4), PLXNB1(12), PLXNB2(8), PLXNB3(2), PLXNC1(9), PPP3CA(4), PPP3CB(1), PPP3R2(5), PTK2(2), RAC1(7), RASA1(1), RGS3(8), RHOD(1), RND1(3), ROBO1(12), ROBO2(17), ROBO3(8), ROCK1(2), ROCK2(4), SEMA3A(8), SEMA3B(2), SEMA3C(2), SEMA3D(6), SEMA3E(11), SEMA3F(5), SEMA3G(8), SEMA4A(5), SEMA4B(3), SEMA4C(4), SEMA4D(5), SEMA4F(5), SEMA4G(4), SEMA5A(10), SEMA5B(9), SEMA6A(5), SEMA6B(5), SEMA6C(5), SEMA6D(2), SEMA7A(1), SLIT1(9), SLIT2(32), SLIT3(25), SRGAP2(2), SRGAP3(17), UNC5A(5), UNC5B(6), UNC5C(9), UNC5D(13)	29831996	763	89	722	407	554	54	24	78	51	2	0.0575	1.000	1.000
152	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(16), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(9), ADCY6(5), ADCY7(6), ADCY8(26), ADCY9(9), ADRA1A(4), ADRA1B(1), ADRA1D(3), ADRB1(3), ADRB2(1), ANXA6(3), ARRB1(1), ARRB2(3), ATP1A4(8), ATP1B1(1), ATP2A2(3), ATP2A3(6), ATP2B1(3), ATP2B2(9), ATP2B3(5), CACNA1A(19), CACNA1B(18), CACNA1C(27), CACNA1D(17), CACNA1E(62), CACNA1S(26), CACNB1(1), CACNB3(2), CALM2(1), CAMK1(4), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CAMK4(8), CASQ1(5), CASQ2(2), CHRM1(4), CHRM2(7), CHRM3(10), CHRM4(4), CHRM5(1), GJA1(4), GJA4(3), GJA5(4), GJB2(3), GJB3(1), GJB4(5), GJB5(2), GJB6(4), GNA11(2), GNAI2(2), GNAO1(1), GNAQ(1), GNAZ(3), GNB3(5), GNB4(1), GNB5(2), GNG2(2), GNG4(2), GNG7(2), GRK4(6), GRK5(3), GRK6(1), ITPR1(16), ITPR2(10), ITPR3(4), KCNB1(13), KCNJ3(11), KCNJ5(6), MIB1(4), NME7(4), PKIA(1), PKIG(1), PLCB3(2), PRKACA(2), PRKACB(2), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCH(2), PRKCQ(12), PRKCZ(1), PRKD1(1), RGS1(3), RGS11(1), RGS14(3), RGS18(4), RGS20(1), RGS3(8), RGS4(2), RGS5(2), RGS6(9), RGS7(22), RGS9(7), RYR1(52), RYR2(42), RYR3(42), SFN(1), SLC8A1(13), SLC8A3(16), USP5(2), YWHAQ(1)	28483462	770	87	742	540	562	64	24	55	62	3	0.441	1.000	1.000
153	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(11), APC2(4), AXIN1(6), AXIN2(2), BTRC(3), CACYBP(1), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CCND2(3), CER1(6), CHD8(11), CHP(1), CREBBP(12), CSNK1A1(1), CSNK1A1L(3), CSNK1E(3), CSNK2B(1), CTNNB1(5), CTNNBIP1(1), CUL1(2), DAAM1(3), DKK1(1), DKK2(7), DKK4(1), DVL2(2), DVL3(4), EP300(7), FBXW11(4), FZD1(1), FZD10(1), FZD2(2), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(3), GSK3B(1), JUN(1), LEF1(1), LRP5(9), LRP6(9), MAPK10(5), MAPK9(1), MMP7(2), MYC(2), NFAT5(3), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), NKD1(5), NKD2(4), NLK(2), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), PORCN(2), PPARD(1), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(2), PPP2R2C(4), PPP3CA(4), PPP3CB(1), PPP3R2(5), PRICKLE1(5), PRICKLE2(2), PRKACA(2), PRKACB(2), PRKACG(5), PRKCA(5), PRKCG(9), PRKX(1), RAC1(7), ROCK1(2), ROCK2(4), SENP2(8), SFRP2(7), SFRP4(3), SMAD2(1), SOX17(2), TBL1X(1), TBL1XR1(1), TBL1Y(3), TCF7L1(1), TCF7L2(3), TP53(20), VANGL1(1), VANGL2(6), WIF1(4), WNT1(1), WNT10A(4), WNT10B(3), WNT11(2), WNT16(1), WNT2(5), WNT2B(1), WNT3(3), WNT3A(5), WNT4(2), WNT5A(4), WNT5B(2), WNT6(2), WNT7A(9), WNT7B(2), WNT8A(4), WNT8B(4), WNT9A(1), WNT9B(3)	24617699	452	87	437	219	299	36	17	58	42	0	0.112	1.000	1.000
154	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(1), AKT2(6), AKT3(2), BRAF(64), DAG1(3), DRD2(8), EGFR(13), EPHB2(15), GRB2(2), ITPKB(4), ITPR1(16), ITPR2(10), ITPR3(4), KCNJ3(11), KCNJ5(6), KCNJ9(2), MAPK1(2), PI3(5), PIK3CB(10), PITX2(1), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), RAF1(2), RGS20(1), SOS1(4), SOS2(3), STAT3(6)	8973715	268	87	210	119	150	21	12	70	15	0	0.0633	1.000	1.000
155	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(1), ADORA2A(1), ADORA2B(1), ADORA3(10), ADRA1A(4), ADRA1B(1), ADRA1D(3), ADRA2A(2), ADRA2C(2), ADRB1(3), ADRB2(1), AGTR1(6), AGTR2(2), AVPR1A(2), AVPR1B(5), BDKRB1(4), BDKRB2(2), BRS3(2), C3AR1(2), CCBP2(5), CCKAR(8), CCKBR(8), CCR1(5), CCR10(1), CCR2(6), CCR3(7), CCR4(4), CCR5(4), CCR6(1), CCR7(2), CCR8(2), CCR9(2), CCRL2(1), CHML(1), CHRM1(4), CHRM2(7), CHRM3(10), CHRM4(4), CHRM5(1), CMKLR1(7), CNR1(7), CNR2(1), CX3CR1(9), CXCR3(2), DRD1(7), DRD2(8), DRD3(1), DRD4(1), DRD5(16), EDNRA(3), EDNRB(3), F2R(3), F2RL1(7), F2RL2(3), FPR1(15), FSHR(9), GALR1(3), GALT(2), GHSR(5), GNB2L1(1), GPR173(1), GPR174(5), GPR27(2), GPR3(2), GPR35(2), GPR37(4), GPR37L1(3), GPR4(3), GPR50(8), GPR6(4), GPR63(4), GPR77(3), GPR83(6), GPR85(3), GPR87(3), GRPR(2), HCRTR2(15), HRH1(9), HRH2(3), HRH3(3), HTR1A(6), HTR1D(2), HTR1E(3), HTR1F(5), HTR2A(6), HTR2C(5), HTR4(4), HTR5A(10), HTR6(1), HTR7(4), LHCGR(10), MAS1(1), MC3R(6), MC4R(1), MC5R(4), MLNR(1), MTNR1A(6), MTNR1B(5), NMBR(2), NMUR1(2), NMUR2(9), NPY1R(10), NPY2R(8), NPY5R(11), NTSR1(3), NTSR2(1), OPN1SW(1), OPN3(1), OPRK1(14), OPRL1(3), OPRM1(4), OR10A5(3), OR11A1(2), OR12D3(4), OR1C1(5), OR1F1(2), OR1Q1(4), OR2H1(4), OR5V1(7), OR7C1(1), OR8B8(7), OXTR(3), P2RY1(1), P2RY10(6), P2RY12(1), P2RY13(2), P2RY14(5), P2RY2(3), P2RY6(1), PPYR1(9), PTGDR(7), PTGER2(4), PTGFR(12), PTGIR(3), RGR(3), RHO(2), SSTR1(5), SSTR2(1), SSTR3(9), SSTR4(1), SUCNR1(7), TBXA2R(3), TRHR(9)	18558718	620	86	604	494	432	62	22	57	47	0	0.0553	1.000	1.000
156	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTB(3), ACTG1(3), ACTN1(2), ACTN2(14), ACTN3(5), ACTN4(2), AKT1(1), AKT2(6), AKT3(2), AMOTL1(2), ASH1L(18), CASK(2), CDK4(2), CGN(5), CLDN1(5), CLDN10(3), CLDN11(3), CLDN14(4), CLDN16(4), CLDN17(3), CLDN18(3), CLDN19(2), CLDN2(2), CLDN20(1), CLDN22(1), CLDN4(5), CLDN6(4), CLDN7(1), CLDN8(2), CLDN9(1), CSDA(1), CSNK2B(1), CTNNA1(2), CTNNA2(14), CTNNA3(13), CTNNB1(5), CTTN(1), EPB41(4), EPB41L1(6), EPB41L2(8), EPB41L3(5), EXOC3(2), EXOC4(4), F11R(4), GNAI2(2), HCLS1(7), IGSF5(5), INADL(24), JAM2(6), JAM3(1), KRAS(1), LLGL1(1), LLGL2(6), MAGI1(16), MAGI2(14), MAGI3(8), MLLT4(8), MPDZ(7), MYH1(46), MYH10(5), MYH11(20), MYH13(18), MYH14(10), MYH15(30), MYH2(38), MYH3(12), MYH4(44), MYH6(15), MYH7(27), MYH7B(18), MYH8(28), MYH9(6), MYL2(4), MYL9(1), MYLPF(1), NRAS(29), OCLN(2), PARD3(9), PARD6G(2), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(2), PPP2R2C(4), PPP2R3A(2), PPP2R3B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCH(2), PRKCI(4), PRKCQ(12), PRKCZ(1), PTEN(11), RRAS(1), SPTAN1(2), SYMPK(2), TJAP1(2), TJP1(5), TJP2(3), TJP3(9), YES1(3), ZAK(4)	29640978	751	86	709	498	515	61	31	76	65	3	0.884	1.000	1.000
157	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(16), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(9), ADCY6(5), ADCY7(6), ADCY8(26), ADCY9(9), CALM2(1), CALML3(3), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CREB3L1(2), CREB3L2(5), CREB3L3(5), CREB3L4(1), CREBBP(12), CTNNB1(5), DCT(1), DVL2(2), DVL3(4), EDN1(6), EDNRB(3), EP300(7), FZD1(1), FZD10(1), FZD2(2), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(3), GNAI2(2), GNAO1(1), GNAQ(1), GNAS(12), GSK3B(1), KIT(7), KITLG(6), KRAS(1), LEF1(1), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK3(1), MITF(1), NRAS(29), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), POMC(3), PRKACA(2), PRKACB(2), PRKACG(5), PRKCA(5), PRKCG(9), PRKX(1), RAF1(2), TCF7L1(1), TCF7L2(3), TYR(2), TYRP1(3), WNT1(1), WNT10A(4), WNT10B(3), WNT11(2), WNT16(1), WNT2(5), WNT2B(1), WNT3(3), WNT3A(5), WNT4(2), WNT5A(4), WNT5B(2), WNT6(2), WNT7A(9), WNT7B(2), WNT8A(4), WNT8B(4), WNT9A(1), WNT9B(3)	16536692	394	86	357	207	265	24	19	53	33	0	0.0515	1.000	1.000
158	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(3), ACTA2(3), ADCY1(16), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(9), ADCY6(5), ADCY7(6), ADCY8(26), ADCY9(9), ARRB1(1), ARRB2(3), ATF1(2), ATF2(5), ATF4(4), ATF5(2), ATP2A2(3), ATP2A3(6), CACNB3(2), CALM2(1), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CNN1(1), CNN2(2), CORIN(12), CRH(2), CRHR1(1), DGKZ(6), ETS2(7), FOS(1), GABPB2(4), GBA2(2), GJA1(4), GNAQ(1), GNB3(5), GNB4(1), GNB5(2), GNG2(2), GNG4(2), GNG7(2), GRK4(6), GRK5(3), GRK6(1), GSTO1(2), GUCY1A3(18), IGFBP1(1), IGFBP2(1), IGFBP3(1), IGFBP6(2), IL1B(2), ITPR1(16), ITPR2(10), ITPR3(4), JUN(1), MIB1(4), MYL2(4), MYL4(5), MYLK2(4), NFKB1(1), NOS1(32), NOS3(11), OXTR(3), PDE4B(4), PDE4D(3), PKIA(1), PKIG(1), PLCB3(2), PLCD1(2), PLCG1(4), PLCG2(9), PRKACA(2), PRKACB(2), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCH(2), PRKCQ(12), PRKCZ(1), PRKD1(1), RAMP1(1), RAMP3(1), RGS1(3), RGS11(1), RGS14(3), RGS18(4), RGS20(1), RGS3(8), RGS4(2), RGS5(2), RGS6(9), RGS7(22), RGS9(7), RLN1(3), RYR1(52), RYR2(42), RYR3(42), SFN(1), SLC8A1(13), SP1(3), TNXB(65), USP5(2), YWHAQ(1)	26645913	665	86	645	400	494	51	18	48	51	3	0.0641	1.000	1.000
159	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(5), BRAF(64), CHUK(1), DAXX(4), FOS(1), GRB2(2), IKBKB(2), JUN(1), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAP2K5(2), MAP2K6(2), MAP2K7(2), MAP3K10(5), MAP3K11(3), MAP3K12(2), MAP3K13(5), MAP3K14(1), MAP3K2(2), MAP3K3(3), MAP3K4(9), MAP3K5(9), MAP3K6(5), MAP3K9(13), MAP4K1(3), MAP4K2(4), MAP4K3(4), MAP4K4(5), MAP4K5(2), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(2), MAPK14(4), MAPK3(1), MAPK4(8), MAPK6(2), MAPK7(2), MAPK9(1), MAPKAPK2(2), MAPKAPK3(1), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), MKNK1(5), MKNK2(2), MYC(2), NFKB1(1), NFKBIA(1), PAK1(2), PAK2(2), RAC1(7), RAF1(2), RELA(1), RIPK1(1), RPS6KA1(2), RPS6KA2(4), RPS6KA4(2), RPS6KA5(3), RPS6KB1(1), RPS6KB2(2), SP1(3), STAT1(2), TGFB2(1), TGFB3(1), TRAF2(1)	14478089	260	85	206	109	147	26	10	64	13	0	0.126	1.000	1.000
160	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(16), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(9), ADCY6(5), ADCY7(6), ADCY8(26), ADCY9(9), ATF4(4), CACNA1C(27), CACNA1D(17), CACNA1F(13), CACNA1S(26), CALM2(1), CALML3(3), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), EGFR(13), FSHB(2), GNA11(2), GNAQ(1), GNAS(12), GNRH2(2), GNRHR(2), GRB2(2), ITPR1(16), ITPR2(10), ITPR3(4), JUN(1), KRAS(1), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP2K7(2), MAP3K2(2), MAP3K3(3), MAP3K4(9), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(2), MAPK14(4), MAPK3(1), MAPK7(2), MAPK9(1), MMP2(3), NRAS(29), PLA2G12B(3), PLA2G2A(1), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(12), PLA2G4A(7), PLA2G6(7), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), PLD1(5), PLD2(2), PRKACA(2), PRKACB(2), PRKACG(5), PRKCA(5), PRKCD(2), PRKX(1), PTK2B(7), RAF1(2), SOS1(4), SOS2(3)	19285471	476	84	437	291	326	39	23	54	34	0	0.354	1.000	1.000
161	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(16), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(9), ADCY6(5), ADCY7(6), ADCY8(26), ADCY9(9), AKAP1(7), AKAP11(6), AKAP12(1), AKAP3(8), AKAP4(5), AKAP6(16), AKAP7(1), AKAP8(5), AKAP9(18), ARHGEF1(1), CALM2(1), CHMP1B(1), GNA11(2), GNA12(2), GNA13(1), GNA14(3), GNA15(2), GNAI2(2), GNAL(2), GNAO1(1), GNAQ(1), GNAZ(3), GNB3(5), GNB5(2), GNG4(2), GNG7(2), GNGT2(2), ITPR1(16), KCNJ3(11), KRAS(1), NRAS(29), PDE1A(21), PDE1B(6), PDE1C(23), PDE4A(2), PDE4B(4), PDE4C(7), PDE4D(3), PDE7B(10), PDE8A(2), PDE8B(10), PLCB3(2), PPP3CA(4), PRKACA(2), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCH(2), PRKCI(4), PRKCQ(12), PRKCZ(1), PRKD1(1), PRKD3(2), RRAS(1), SLC9A1(1), USP5(2)	17909276	393	83	364	216	267	28	18	50	30	0	0.198	1.000	1.000
162	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM2(1), CALML3(3), CDS1(5), CDS2(2), DGKA(1), DGKB(14), DGKD(3), DGKE(5), DGKG(8), DGKH(6), DGKI(12), DGKQ(2), DGKZ(6), IMPA1(1), IMPA2(1), INPP1(2), INPP4A(4), INPP5A(2), INPP5B(3), INPP5D(19), INPPL1(9), ITPK1(4), ITPKB(4), ITPR1(16), ITPR2(10), ITPR3(4), OCRL(2), PI4KA(7), PIK3C2A(3), PIK3C2B(7), PIK3C2G(20), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PIP4K2A(3), PIP4K2B(2), PIP4K2C(1), PIP5K1A(6), PIP5K1B(11), PIP5K1C(4), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), PLCD1(2), PLCD3(1), PLCD4(1), PLCE1(22), PLCG1(4), PLCG2(9), PLCZ1(8), PRKCA(5), PRKCG(9), PTEN(11), SYNJ1(8), SYNJ2(9)	18974252	405	83	392	208	289	24	19	35	38	0	0.0660	1.000	1.000
163	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(16), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(9), ADCY6(5), ADCY7(6), ADCY8(26), ADCY9(9), ADRB1(3), CSNK1D(1), DRD1(7), DRD2(8), EGF(14), EGFR(13), GJA1(4), GNA11(2), GNAI2(2), GNAQ(1), GNAS(12), GRB2(2), GRM1(7), GRM5(5), GUCY1A2(8), GUCY1A3(18), GUCY1B3(4), GUCY2C(16), GUCY2D(3), GUCY2F(7), HTR2A(6), HTR2C(5), ITPR1(16), ITPR2(10), ITPR3(4), KRAS(1), MAP2K1(3), MAP2K2(2), MAP2K5(2), MAP3K2(2), MAPK1(2), MAPK3(1), MAPK7(2), NPR1(12), NPR2(11), NRAS(29), PDGFA(1), PDGFB(1), PDGFC(12), PDGFD(2), PDGFRA(13), PDGFRB(7), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), PRKACA(2), PRKACB(2), PRKACG(5), PRKCA(5), PRKCG(9), PRKG1(5), PRKG2(8), PRKX(1), RAF1(2), SOS1(4), SOS2(3), TJP1(5), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(10), TUBA3D(5), TUBA3E(1), TUBA4A(3), TUBA8(1), TUBAL3(8), TUBB1(2), TUBB2A(1), TUBB3(3), TUBB4(1), TUBB4Q(4), TUBB6(5), TUBB8(6)	20143435	533	83	487	310	376	34	24	59	40	0	0.115	1.000	1.000
164	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(17), BDKRB1(4), BDKRB2(2), C1QA(3), C1QB(1), C1QC(4), C1R(8), C1S(11), C2(8), C3(21), C3AR1(2), C4BPA(9), C4BPB(3), C5(5), C5AR1(4), C6(36), C7(17), C8A(23), C8B(25), C9(11), CD55(2), CD59(1), CFB(21), CFH(23), CFI(7), CR1(29), CR2(16), F10(2), F11(8), F12(1), F13A1(16), F13B(13), F2(6), F2R(3), F5(19), F7(2), F8(21), F9(6), FGA(19), FGB(6), FGG(3), KLKB1(15), KNG1(3), MASP1(5), MASP2(7), MBL2(7), PLAT(2), PLAU(2), PLG(14), PROC(7), PROS1(8), SERPINA1(6), SERPINA5(5), SERPINC1(5), SERPIND1(2), SERPINE1(2), SERPINF2(3), SERPING1(7), TFPI(5), THBD(2), VWF(28)	13831525	573	83	549	262	428	40	17	46	40	2	0.0190	1.000	1.000
165	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(1), ATF1(2), BRAF(64), CREB5(7), CREBBP(12), DAG1(3), EGR1(1), EGR2(3), EGR3(1), EGR4(1), FRS2(1), GNAQ(1), JUN(1), MAP1B(12), MAP2K4(3), MAP2K7(2), MAPK1(2), MAPK10(5), MAPK3(1), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1), NTRK1(9), OPN1LW(3), PIK3C2G(20), PIK3CA(2), PIK3CD(2), PIK3R1(2), PTPN11(3), TH(6)	7840314	182	83	131	72	102	7	6	59	8	0	0.109	1.000	1.000
166	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(2), ADCY1(16), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(9), ADCY6(5), ADCY7(6), ADCY8(26), ADCY9(9), ADK(3), ADSL(6), ADSSL1(4), AK1(1), AK2(1), AK5(5), AK7(12), ALLC(3), AMPD1(19), AMPD2(2), AMPD3(14), ATIC(1), CANT1(4), DGUOK(4), ENPP1(7), ENPP3(8), ENTPD1(5), ENTPD2(3), ENTPD3(3), ENTPD4(2), ENTPD6(2), ENTPD8(1), FHIT(1), GART(5), GDA(5), GMPS(3), GUCY1A2(8), GUCY1A3(18), GUCY1B3(4), GUCY2C(16), GUCY2D(3), GUCY2F(7), IMPDH2(1), NME7(4), NPR1(12), NPR2(11), NT5C1B(16), NT5C3(2), NT5E(3), NT5M(1), NUDT5(1), NUDT9(1), PAPSS1(1), PAPSS2(2), PDE10A(6), PDE11A(12), PDE1A(21), PDE1C(23), PDE2A(7), PDE3B(3), PDE4A(2), PDE4B(4), PDE4C(7), PDE4D(3), PDE5A(4), PDE6D(2), PDE6G(2), PDE7B(10), PDE8A(2), PDE8B(10), PDE9A(4), PFAS(2), PKLR(6), PKM2(4), PNPT1(1), POLA1(1), POLA2(6), POLD1(2), POLD2(1), POLD3(3), POLE(9), POLE2(1), POLR1A(7), POLR1B(4), POLR1C(1), POLR2A(8), POLR2B(10), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2L(1), POLR3A(2), POLR3B(10), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(8), PRPS1(1), PRPS1L1(7), PRPS2(1), PRUNE(1), RRM1(2), RRM2B(1), XDH(33)	25072558	580	82	566	283	412	43	26	47	52	0	0.00191	1.000	1.000
167	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(1), AKT2(6), AKT3(2), BRAF(64), CAB39(1), EIF4B(1), FIGF(4), IGF1(6), MAPK1(2), MAPK3(1), PDPK1(1), PGF(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PRKAA1(1), PRKAA2(15), RICTOR(5), RPS6(1), RPS6KA1(2), RPS6KA2(4), RPS6KA6(3), RPS6KB1(1), RPS6KB2(2), STK11(2), TSC1(3), TSC2(6), ULK1(4), ULK2(4), ULK3(1), VEGFA(1), VEGFB(1), VEGFC(13)	8074143	195	82	143	76	100	9	8	66	12	0	0.129	1.000	1.000
168	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(10), CD14(3), CD19(3), CD1A(5), CD1B(4), CD1C(12), CD1D(6), CD1E(9), CD2(13), CD22(15), CD33(9), CD36(3), CD37(1), CD38(3), CD3D(4), CD3E(2), CD4(3), CD44(4), CD5(3), CD55(2), CD59(1), CD8A(1), CD8B(4), CR1(29), CR2(16), CSF1(7), CSF1R(6), CSF2(2), CSF2RA(8), CSF3(1), CSF3R(5), DNTT(7), EPO(4), EPOR(1), FCER2(1), FCGR1A(3), FLT3(18), FLT3LG(1), GP5(2), GP9(4), GYPA(3), HLA-DRA(5), IL11(2), IL11RA(1), IL1A(2), IL1B(2), IL1R1(6), IL1R2(5), IL2RA(4), IL3(2), IL3RA(4), IL4(1), IL4R(5), IL5(4), IL5RA(7), IL6R(2), IL7(3), IL7R(15), IL9R(4), ITGA1(14), ITGA2(7), ITGA2B(6), ITGA3(4), ITGA4(18), ITGA5(11), ITGA6(5), ITGAM(14), ITGB3(7), KIT(7), KITLG(6), MME(11), MS4A1(4), TFRC(3), THPO(3), TNF(1), TPO(28)	12460405	461	82	440	236	350	26	13	28	44	0	0.0814	1.000	1.000
169	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(1), AKT2(6), AKT3(2), BCL10(1), CARD11(18), CBL(4), CBLB(7), CBLC(12), CD247(1), CD3D(4), CD3E(2), CD4(3), CD40LG(1), CD8A(1), CD8B(4), CDK4(2), CHP(1), CHUK(1), CSF2(2), CTLA4(1), FOS(1), FYN(4), GRAP2(1), GRB2(2), ICOS(2), IFNG(2), IKBKB(2), IL10(1), IL2(4), IL4(1), IL5(4), ITK(15), JUN(1), KRAS(1), LCK(4), LCP2(5), MALT1(2), MAP3K14(1), NCK2(3), NFAT5(3), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(1), NRAS(29), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PAK7(27), PDCD1(3), PDK1(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PLCG1(4), PPP3CA(4), PPP3CB(1), PPP3R2(5), PRKCQ(12), PTPN6(1), PTPRC(18), RASGRP1(6), SOS1(4), SOS2(3), TEC(6), TNF(1), VAV1(12), VAV2(3), VAV3(5), ZAP70(4)	15556662	359	82	322	175	236	23	20	59	21	0	0.285	1.000	1.000
170	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(11), AMY2A(3), AMY2B(5), ASCC3(4), ATP13A2(6), DDX18(1), DDX23(4), DDX4(7), DDX41(3), DDX47(1), DDX50(2), DDX51(3), DDX52(3), DDX55(2), DDX56(2), DHX58(3), ENPP1(7), ENPP3(8), ENTPD7(1), EP400(13), ERCC2(1), ERCC3(2), G6PC(4), G6PC2(2), GAA(3), GANC(1), GBA(2), GBA3(5), GBE1(7), GCK(8), GPI(2), GUSB(2), GYS1(2), GYS2(10), HK1(1), HK2(4), HK3(10), IFIH1(4), MGAM(71), MOV10L1(16), NUDT5(1), NUDT8(1), PGM1(2), PGM3(1), PYGB(2), PYGL(2), PYGM(6), RAD54B(4), RUVBL2(1), SETX(12), SI(34), SKIV2L2(3), SMARCA2(8), SMARCA5(3), TREH(1), UGP2(1), UGT1A1(1), UGT1A10(10), UGT1A3(6), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(7), UGT1A8(2), UGT1A9(5), UGT2A1(8), UGT2A3(14), UGT2B10(17), UGT2B11(10), UGT2B15(16), UGT2B28(14), UGT2B4(18), UGT2B7(8), UXS1(1)	18811600	476	81	457	202	333	38	14	44	47	0	0.00141	1.000	1.000
171	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), AKR1C1(2), AKR1C2(2), AKR1C3(6), AKR1C4(4), ALDH1A3(2), ALDH3A1(3), ALDH3B1(1), ALDH3B2(4), CYP1A1(8), CYP1A2(8), CYP1B1(1), CYP2B6(9), CYP2C18(17), CYP2C19(25), CYP2C8(18), CYP2C9(24), CYP2E1(8), CYP2F1(6), CYP2S1(6), CYP3A4(12), CYP3A43(8), CYP3A5(4), CYP3A7(12), DHDH(4), EPHX1(1), GSTA1(5), GSTA3(1), GSTA5(1), GSTK1(1), GSTM1(1), GSTM3(1), GSTM4(1), GSTM5(2), MGST1(1), MGST2(1), UGT1A1(1), UGT1A10(10), UGT1A3(6), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(7), UGT1A8(2), UGT1A9(5), UGT2A1(8), UGT2A3(14), UGT2B10(17), UGT2B11(10), UGT2B15(16), UGT2B28(14), UGT2B4(18), UGT2B7(8)	8765053	421	81	401	182	316	28	19	27	31	0	1.30e-05	1.000	1.000
172	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ABL1(3), ANAPC1(6), ANAPC2(1), ANAPC5(3), ANAPC7(4), ATM(8), ATR(13), BUB1B(5), CCNA1(7), CCNB2(1), CCNB3(16), CCND2(3), CCNE1(1), CCNE2(10), CCNH(1), CDC14A(2), CDC14B(1), CDC16(1), CDC25A(5), CDC25B(1), CDC25C(3), CDC27(5), CDC6(1), CDC7(2), CDK4(2), CDKN1A(1), CDKN2A(16), CHEK1(1), CREBBP(12), CUL1(2), DBF4(2), E2F1(5), E2F2(1), E2F3(2), EP300(7), ESPL1(10), FZR1(1), GADD45B(1), GSK3B(1), HDAC1(1), MAD1L1(2), MCM2(7), MCM3(5), MCM4(2), MCM5(2), MCM6(2), MDM2(2), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(1), ORC5L(1), ORC6L(2), PCNA(1), PKMYT1(1), PRKDC(11), PTTG1(1), PTTG2(3), RB1(3), RBL1(4), RBL2(2), SFN(1), SMAD2(1), SMC1A(2), SMC1B(8), TGFB2(1), TGFB3(1), TP53(20), YWHAG(1), YWHAQ(1)	21007224	260	81	247	98	149	17	16	36	40	2	0.0131	1.000	1.000
173	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(3), CADM1(1), CADM3(6), CD2(13), CD22(15), CD226(4), CD274(1), CD276(4), CD4(3), CD40(1), CD40LG(1), CD58(1), CD6(4), CD86(12), CD8A(1), CD8B(4), CD99(1), CDH1(4), CDH15(6), CDH2(9), CDH4(17), CDH5(4), CLDN1(5), CLDN10(3), CLDN11(3), CLDN14(4), CLDN16(4), CLDN17(3), CLDN18(3), CLDN19(2), CLDN2(2), CLDN20(1), CLDN22(1), CLDN4(5), CLDN6(4), CLDN7(1), CLDN8(2), CLDN9(1), CNTN1(10), CNTN2(4), CNTNAP1(7), CNTNAP2(44), CTLA4(1), ESAM(3), F11R(4), GLG1(1), HLA-A(1), HLA-B(4), HLA-C(1), HLA-DMA(2), HLA-DMB(3), HLA-DOA(3), HLA-DOB(1), HLA-DQA1(3), HLA-DQA2(2), HLA-DQB1(3), HLA-DRA(5), HLA-F(4), HLA-G(3), ICAM1(2), ICAM2(4), ICAM3(2), ICOS(2), ICOSLG(2), ITGA4(18), ITGA6(5), ITGA8(22), ITGA9(9), ITGAL(15), ITGAM(14), ITGAV(4), ITGB1(3), ITGB2(8), ITGB7(3), ITGB8(9), JAM2(6), JAM3(1), L1CAM(3), MADCAM1(1), MAG(10), MPZ(4), MPZL1(1), NCAM1(5), NCAM2(4), NEGR1(3), NEO1(6), NFASC(25), NLGN1(3), NLGN2(5), NLGN3(5), NRCAM(7), NRXN1(30), NRXN2(10), NRXN3(16), OCLN(2), PDCD1(3), PDCD1LG2(1), PTPRC(18), PTPRF(15), PTPRM(4), PVRL1(3), PVRL2(2), PVRL3(1), SDC1(1), SDC2(1), SDC3(3), SDC4(2), SELE(19), SELL(5), SELP(13), SELPLG(3), SIGLEC1(12), SPN(3), VCAM1(13), VCAN(19)	22383670	678	81	652	340	510	50	21	51	46	0	0.00477	1.000	1.000
174	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(2), ACTN2(14), ACTN3(5), ACTN4(2), ARHGAP5(7), BCAR1(3), CD99(1), CDH5(4), CLDN1(5), CLDN10(3), CLDN11(3), CLDN14(4), CLDN16(4), CLDN17(3), CLDN18(3), CLDN19(2), CLDN2(2), CLDN20(1), CLDN22(1), CLDN4(5), CLDN6(4), CLDN7(1), CLDN8(2), CLDN9(1), CTNNA1(2), CTNNA2(14), CTNNA3(13), CTNNB1(5), CTNND1(7), CXCL12(1), CYBA(1), CYBB(3), ESAM(3), EZR(1), F11R(4), GNAI2(2), GRLF1(3), ICAM1(2), ITGA4(18), ITGAL(15), ITGAM(14), ITGB1(3), ITGB2(8), ITK(15), JAM2(6), JAM3(1), MAPK11(1), MAPK13(2), MAPK14(4), MLLT4(8), MMP2(3), MMP9(5), MYL2(4), MYL9(1), MYLPF(1), NCF2(4), NCF4(1), NOX1(6), NOX3(4), OCLN(2), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PLCG1(4), PLCG2(9), PRKCA(5), PRKCG(9), PTK2(2), PTK2B(7), PTPN11(3), PXN(3), RAC1(7), RAP1A(1), RAPGEF3(4), RAPGEF4(7), RASSF5(3), RHOH(3), ROCK1(2), ROCK2(4), SIPA1(4), TXK(5), VAV1(12), VAV2(3), VAV3(5), VCAM1(13), VCL(4)	18928934	424	81	413	229	304	23	10	50	35	2	0.121	1.000	1.000
175	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(1), APC(11), AR(7), BRAF(64), CCL15(2), CCL16(1), DAG1(3), EGFR(13), GNA11(2), GNA15(2), GNAQ(1), ITPKB(4), ITPR1(16), ITPR2(10), ITPR3(4), KCNJ3(11), KCNJ5(6), KCNJ9(2), MAPK1(2), MAPK10(5), MAPK14(4), PHKA2(5), PIK3CA(2), PIK3CD(2), PIK3R1(2), PITX2(1), RAF1(2)	8135343	185	81	134	85	91	15	7	59	13	0	0.323	1.000	1.000
176	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(1), AKT2(6), AKT3(2), CASP9(2), CHP(1), KDR(22), KRAS(1), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK11(1), MAPK13(2), MAPK14(4), MAPK3(1), MAPKAPK2(2), MAPKAPK3(1), NFAT5(3), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), NOS3(11), NRAS(29), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PLA2G12B(3), PLA2G2A(1), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(12), PLA2G4A(7), PLA2G6(7), PLCG1(4), PLCG2(9), PPP3CA(4), PPP3CB(1), PPP3R2(5), PRKCA(5), PRKCG(9), PTGS2(6), PTK2(2), PXN(3), RAC1(7), RAF1(2), SH2D2A(1), SHC2(4), SPHK1(1), SPHK2(5), VEGFA(1)	11049075	261	78	229	116	168	14	14	49	16	0	0.0453	1.000	1.000
177	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(1), AKT2(6), AKT3(2), BTK(6), CSF2(2), FCER1A(6), FCER1G(1), FYN(4), GAB2(1), GRB2(2), IL13(2), IL3(2), IL4(1), IL5(4), INPP5D(19), KRAS(1), LCP2(5), LYN(1), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP2K7(2), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(2), MAPK14(4), MAPK3(1), MAPK9(1), MS4A2(5), NRAS(29), PDK1(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PLA2G12B(3), PLA2G2A(1), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(12), PLA2G4A(7), PLA2G6(7), PLCG1(4), PLCG2(9), PRKCA(5), PRKCD(2), PRKCE(3), RAC1(7), RAF1(2), SOS1(4), SOS2(3), SYK(9), TNF(1), VAV1(12), VAV2(3), VAV3(5)	11068476	277	78	247	106	173	19	19	46	20	0	0.00178	1.000	1.000
178	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), AKT3(2), BCAR1(3), CAPN1(1), CAPN10(6), CAPN11(5), CAPN2(2), CAPN3(6), CAPN5(2), CAPN6(8), CAPN7(1), CAPN9(6), CAV1(1), CRK(2), CSK(1), DOCK1(11), FYN(4), GIT2(2), GRB2(2), ITGA10(2), ITGA11(12), ITGA2(7), ITGA2B(6), ITGA3(4), ITGA4(18), ITGA5(11), ITGA6(5), ITGA7(15), ITGA8(22), ITGA9(9), ITGAD(16), ITGAE(8), ITGAL(15), ITGAM(14), ITGAV(4), ITGAX(10), ITGB1(3), ITGB2(8), ITGB3(7), ITGB4(11), ITGB6(8), ITGB7(3), ITGB8(9), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K6(2), MAPK10(5), MAPK4(8), MAPK6(2), MAPK7(2), MYLK2(4), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PDPK1(1), PIK3R2(1), PTK2(2), PXN(3), RAC1(7), RAPGEF1(3), RHO(2), ROCK1(2), ROCK2(4), SDCCAG8(2), SEPP1(1), SHC3(7), SORBS1(6), SOS1(4), TLN1(10), TNS1(5), VAV2(3), VAV3(5), VCL(4), ZYX(3)	20358848	414	75	406	198	307	27	18	38	23	1	0.00854	1.000	1.000
179	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(16), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(9), ADCY6(5), ADCY7(6), ADCY8(26), ADK(3), ADSL(6), AK1(1), AK2(1), AK5(5), ALLC(3), AMPD1(19), AMPD2(2), AMPD3(14), ATIC(1), ATP1B1(1), ATP5A1(1), ATP5B(1), ATP5C1(1), ATP5F1(6), ATP5H(1), CANT1(4), DGUOK(4), ENPP1(7), ENPP3(8), ENTPD1(5), ENTPD2(3), FHIT(1), GART(5), GDA(5), GMPS(3), GUCY1A2(8), GUCY1A3(18), GUCY1B3(4), GUCY2C(16), GUCY2D(3), GUCY2F(7), IMPDH2(1), NPR1(12), NPR2(11), NT5E(3), NT5M(1), PAPSS1(1), PAPSS2(2), PDE1A(21), PDE4A(2), PDE4B(4), PDE4C(7), PDE4D(3), PDE5A(4), PDE6B(11), PDE6C(16), PDE6G(2), PDE7B(10), PDE8A(2), PDE9A(4), PFAS(2), PKLR(6), PKM2(4), POLD1(2), POLD2(1), POLE(9), POLG(4), POLL(6), POLQ(12), POLR1B(4), POLR2A(8), POLR2B(10), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2L(1), POLRMT(1), PRPS1(1), PRPS1L1(7), PRPS2(1), PRUNE(1), RRM1(2)	19609160	444	75	426	217	317	32	11	37	47	0	0.00292	1.000	1.000
180	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(18), ASH2L(2), CARM1(2), CTCFL(10), DOT1L(4), EED(2), EHMT1(5), EHMT2(3), EZH1(2), EZH2(6), FBXO11(1), HCFC1(9), JMJD4(2), JMJD6(1), MEN1(2), MLL(19), MLL2(30), MLL3(28), MLL4(23), MLL5(3), NSD1(8), OGT(3), PAXIP1(1), PPP1CA(1), PPP1CB(3), PPP1CC(1), PRDM2(9), PRDM7(2), PRDM9(28), PRMT5(3), PRMT6(1), PRMT7(1), PRMT8(7), RBBP5(4), SATB1(8), SETD1A(15), SETD2(9), SETD7(1), SETDB1(1), SETDB2(2), SETMAR(3), STK38(2), SUV420H1(3), SUV420H2(1), SUZ12(2), WHSC1(4), WHSC1L1(3)	18136212	298	74	295	116	198	36	8	32	24	0	0.0757	1.000	1.000
181	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(3), ATM(8), BUB1B(5), CCNA1(7), CCNB2(1), CCNB3(16), CCND2(3), CCNE1(1), CCNE2(10), CCNH(1), CDAN1(4), CDC14A(2), CDC14B(1), CDC25A(5), CDC25B(1), CDC25C(3), CDC6(1), CDC7(2), CDH1(4), CDK4(2), CDKN1A(1), CDKN2A(16), CHEK1(1), DTX4(2), E2F1(5), E2F2(1), E2F3(2), EP300(7), ESPL1(10), GSK3B(1), HDAC1(1), HDAC3(3), HDAC4(8), HDAC5(3), HDAC6(1), HDAC8(2), MAD1L1(2), MCM2(7), MCM3(5), MCM4(2), MCM5(2), MCM6(2), MDM2(2), MPEG1(5), MPL(1), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(1), ORC5L(1), ORC6L(2), PCNA(1), PRKDC(11), PTPRA(2), PTTG1(1), PTTG2(3), RB1(3), RBL1(4), TBC1D8(4), TP53(20)	16868148	229	74	218	81	138	17	10	28	34	2	0.00136	1.000	1.000
182	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(8), CCNA1(7), CCND2(3), CCNE1(1), CCNE2(10), CCNH(1), CDC25A(5), CDK4(2), CDKN1A(1), CDKN2A(16), CREB3L1(2), CREB3L3(5), CREB3L4(1), E2F1(5), E2F2(1), E2F3(2), GBA2(2), MCM2(7), MCM3(5), MCM4(2), MCM5(2), MCM6(2), MDM2(2), MNAT1(2), MYC(2), MYT1(12), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(1), ORC5L(1), ORC6L(2), PCNA(1), POLA2(6), POLE(9), POLE2(1), PRIM1(1), RB1(3), RBL1(4), RPA1(1), TFDP2(3), TNXB(65), TP53(20)	12192720	230	74	220	86	147	10	4	29	38	2	0.00320	1.000	1.000
183	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AKT1(1), AKT2(6), AKT3(2), APAF1(3), ATM(8), BAX(1), BCL2(2), BIRC2(4), BIRC3(5), CAPN1(1), CAPN2(2), CASP10(3), CASP7(3), CASP8(1), CASP9(2), CFLAR(3), CHP(1), CHUK(1), CSF2RB(8), CYCS(1), DFFA(1), DFFB(2), FAS(3), FASLG(10), IKBKB(2), IL1A(2), IL1B(2), IL1R1(6), IL1RAP(2), IL3(2), IL3RA(4), IRAK2(8), IRAK3(5), IRAK4(2), MAP3K14(1), MYD88(1), NFKB1(1), NFKB2(3), NFKBIA(1), NTRK1(9), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PPP3CA(4), PPP3CB(1), PPP3R2(5), PRKACA(2), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), RELA(1), RIPK1(1), TNF(1), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10C(3), TNFRSF10D(4), TNFRSF1A(2), TNFSF10(5), TP53(20), TRAF2(1)	12761197	228	74	224	116	145	12	13	31	27	0	0.345	1.000	1.000
184	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(2), ACTB(3), ACTG1(3), ACTN1(2), ACTN2(14), ACTN3(5), ACTN4(2), ACVR1B(3), ACVR1C(7), BAIAP2(2), CDH1(4), CREBBP(12), CSNK2B(1), CTNNA1(2), CTNNA2(14), CTNNA3(13), CTNNB1(5), CTNND1(7), EGFR(13), EP300(7), ERBB2(2), FARP2(2), FER(1), FGFR1(6), FYN(4), IGF1R(5), INSR(11), IQGAP1(7), LEF1(1), LMO7(17), MAPK1(2), MAPK3(1), MET(7), MLLT4(8), NLK(2), PARD3(9), PTPN1(1), PTPN6(1), PTPRB(52), PTPRF(15), PTPRJ(4), PTPRM(4), PVRL1(3), PVRL2(2), PVRL3(1), PVRL4(4), RAC1(7), SMAD2(1), SNAI1(1), SNAI2(1), SORBS1(6), SSX2IP(3), TCF7L1(1), TCF7L2(3), TGFBR2(5), TJP1(5), VCL(4), WAS(4), WASF1(1), WASF2(4), WASF3(9), WASL(1), YES1(3)	18458296	352	74	337	186	254	19	7	32	37	3	0.446	1.000	1.000
185	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(1), AKT2(6), AKT3(2), BCL10(1), BLNK(10), BTK(6), CARD11(18), CD19(3), CD22(15), CD72(4), CD79A(1), CD81(2), CHP(1), CHUK(1), CR2(16), FCGR2B(1), FOS(1), GSK3B(1), IKBKB(2), INPP5D(19), JUN(1), KRAS(1), LILRB3(4), LYN(1), MALT1(2), NFAT5(3), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(1), NRAS(29), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), PLCG2(9), PPP3CA(4), PPP3CB(1), PPP3R2(5), PTPN6(1), RAC1(7), RASGRP3(7), SYK(9), VAV1(12), VAV2(3), VAV3(5)	11440800	278	74	247	116	171	15	21	47	24	0	0.0166	1.000	1.000
186	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(1), ACVR1B(3), ACVRL1(4), AKT1(1), AURKB(2), BMPR1A(1), BMPR2(3), CDKL1(3), CDKL2(2), CDS1(5), CDS2(2), CLK1(1), CLK2(2), COL4A3BP(1), CSNK2B(1), DGKA(1), DGKB(14), DGKD(3), DGKE(5), DGKG(8), DGKH(6), DGKQ(2), DGKZ(6), IMPA1(1), INPP1(2), INPP4A(4), INPP5A(2), INPPL1(9), ITPKB(4), MAP3K10(5), MOS(5), NEK1(5), NEK3(1), OCRL(2), PAK4(3), PIK3C2A(3), PIK3C2B(7), PIK3C2G(20), PIK3CA(2), PIK3CB(10), PIK3CG(12), PIM2(1), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), PLCD1(2), PLCG1(4), PLCG2(9), PRKACA(2), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCH(2), PRKCQ(12), PRKCZ(1), PRKD1(1), PRKG1(5), RAF1(2), RPS6KA1(2), RPS6KA2(4), RPS6KA4(2), RPS6KB1(1), STK11(2)	17207911	325	73	313	187	231	18	12	29	35	0	0.660	1.000	1.000
187	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(2), BRAF(64), CREB5(7), DUSP4(1), DUSP6(1), EEF2K(2), GRB2(2), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK3(1), MKNK1(5), MKNK2(2), MOS(5), NFKB1(1), RAP1A(1), RPS6KA1(2), RPS6KA2(4), SOS1(4), SOS2(3), TRAF3(3)	4516827	117	73	66	35	50	6	4	53	4	0	0.0893	1.000	1.000
188	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA1(1), IMPA2(1), INPP1(2), INPP4A(4), INPP5A(2), INPP5B(3), INPPL1(9), IPMK(2), ISYNA1(1), ITPK1(4), ITPKB(4), MIOX(3), OCRL(2), PI4KA(7), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIP4K2A(3), PIP4K2B(2), PIP4K2C(1), PIP5K1A(6), PIP5K1B(11), PIP5K1C(4), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), PLCD1(2), PLCD3(1), PLCD4(1), PLCE1(22), PLCG1(4), PLCG2(9), PLCZ1(8), PTEN(11), SYNJ1(8), SYNJ2(9)	11314892	240	72	232	120	166	11	14	27	22	0	0.131	1.000	1.000
189	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(5), ABCA10(13), ABCA12(30), ABCA13(33), ABCA2(6), ABCA3(11), ABCA4(31), ABCA5(4), ABCA6(20), ABCA7(5), ABCA8(22), ABCA9(11), ABCB1(22), ABCB10(1), ABCB11(27), ABCB4(8), ABCB5(20), ABCB6(1), ABCB7(4), ABCB8(2), ABCB9(1), ABCC1(7), ABCC10(7), ABCC11(9), ABCC12(12), ABCC2(6), ABCC3(17), ABCC4(7), ABCC5(3), ABCC6(11), ABCC8(20), ABCC9(30), ABCD2(6), ABCD3(5), ABCG1(6), ABCG2(6), ABCG4(5), ABCG5(4), ABCG8(11), CFTR(24), TAP1(1), TAP2(11)	18070427	485	72	469	289	345	33	13	45	49	0	0.0739	1.000	1.000
190	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(2), ACADL(2), ACADM(3), ACOX1(3), ACOX2(6), ACOX3(5), ACSL1(2), ACSL3(3), ACSL5(8), ACSL6(4), ADIPOQ(1), ANGPTL4(3), APOA1(1), APOA5(2), AQP7(3), CD36(3), CPT1A(6), CPT1B(4), CPT1C(11), CPT2(1), CYP27A1(2), CYP4A11(12), CYP4A22(16), CYP7A1(4), CYP8B1(5), EHHADH(5), FABP1(3), FABP2(5), FABP3(1), FABP4(1), FADS2(2), GK(4), GK2(13), HMGCS2(11), LPL(2), ME1(11), MMP1(4), NR1H3(2), OLR1(3), PCK1(15), PCK2(2), PDPK1(1), PPARA(3), PPARD(1), PPARG(6), RXRA(1), RXRB(1), RXRG(1), SCD(2), SLC27A1(3), SLC27A2(5), SLC27A4(4), SLC27A5(3), SLC27A6(13), SORBS1(6), UBC(3), UCP1(4)	10092663	253	72	245	154	190	21	10	12	19	1	0.503	1.000	1.000
191	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(1), AKT2(6), AKT3(2), CASP8(1), CD14(3), CD40(1), CD86(12), CHUK(1), CXCL10(2), CXCL11(1), CXCL9(2), FOS(1), IFNA10(1), IFNA14(4), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(6), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR2(3), IFNB1(4), IKBKB(2), IKBKE(5), IL12A(2), IL12B(3), IL1B(2), IL8(1), IRAK4(2), IRF3(1), IRF5(2), IRF7(3), JUN(1), LBP(5), LY96(3), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP2K7(2), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(2), MAPK14(4), MAPK3(1), MAPK9(1), MYD88(1), NFKB1(1), NFKB2(3), NFKBIA(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(12), PIK3R1(2), PIK3R2(1), PIK3R5(7), RAC1(7), RELA(1), RIPK1(1), SPP1(3), STAT1(2), TBK1(2), TICAM1(5), TLR1(5), TLR2(8), TLR3(6), TLR4(21), TLR5(11), TLR6(3), TLR7(3), TLR8(4), TLR9(7), TNF(1), TOLLIP(1), TRAF3(3), TRAF6(2)	13747130	268	72	261	142	188	19	12	31	18	0	0.170	1.000	1.000
192	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(11), AMY2A(3), AMY2B(5), ENPP1(7), ENPP3(8), G6PC(4), GAA(3), GANAB(4), GBA3(5), GBE1(7), GCK(8), GPI(2), GUSB(2), GYS1(2), GYS2(10), HK1(1), HK2(4), HK3(10), MGAM(71), PGM1(2), PGM3(1), PYGB(2), PYGL(2), PYGM(6), SI(34), UCHL1(4), UCHL3(1), UGT1A1(1), UGT1A10(10), UGT1A3(6), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(7), UGT1A8(2), UGT1A9(5), UGT2B15(16), UGT2B4(18), UXS1(1)	8688570	296	72	281	124	211	27	11	22	25	0	0.00270	1.000	1.000
193	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(3), ALG1(2), ALG10B(3), ALG12(1), ALG13(3), ALG2(3), ALG3(1), ALG8(2), ALG9(3), B3GNT1(1), B3GNT2(2), B3GNT7(3), B4GALT2(2), B4GALT3(1), B4GALT5(1), C1GALT1(4), C1GALT1C1(1), CHPF(2), CHST1(7), CHST11(4), CHST12(1), CHST13(1), CHST14(2), CHST2(1), CHST4(6), CHST6(4), CHSY1(5), DDOST(1), DPAGT1(1), EXT2(2), EXTL3(2), FUT11(1), FUT8(4), GALNT1(2), GALNT10(2), GALNT11(1), GALNT12(5), GALNT13(9), GALNT14(14), GALNT2(4), GALNT3(2), GALNT4(2), GALNT5(7), GALNT6(11), GALNT7(4), GALNT8(14), GALNTL1(2), GALNTL2(10), GALNTL4(1), GALNTL5(13), GANAB(4), GCNT1(4), GCNT3(3), HS2ST1(1), HS3ST1(6), HS3ST2(6), HS3ST3B1(2), HS3ST5(5), HS6ST1(1), HS6ST2(1), HS6ST3(9), MAN1A1(8), MAN1A2(3), MAN1B1(2), MAN1C1(4), MAN2A1(6), MGAT3(8), MGAT4A(5), MGAT5(1), MGAT5B(6), NDST1(2), NDST3(13), NDST4(29), OGT(3), RPN2(2), ST3GAL1(5), ST6GAL1(4), ST6GALNAC1(3), STT3B(2), WBSCR17(20), XYLT1(8), XYLT2(1)	16758922	360	71	352	181	257	32	10	27	34	0	0.0178	1.000	1.000
194	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(3), ATM(8), ATR(13), BAI1(10), BAX(1), CASP8(1), CASP9(2), CCNB2(1), CCNB3(16), CCND2(3), CCNE1(1), CCNE2(10), CCNG1(1), CDK4(2), CDKN1A(1), CDKN2A(16), CHEK1(1), CYCS(1), DDB2(2), EI24(1), FAS(3), GADD45B(1), GTSE1(5), IGF1(6), IGFBP3(1), LRDD(1), MDM2(2), MDM4(1), PERP(1), PPM1D(2), PTEN(11), RFWD2(2), RRM2B(1), SERPINB5(8), SERPINE1(2), SESN2(3), SESN3(1), SFN(1), STEAP3(2), THBS1(15), TNFRSF10B(1), TP53(20), TP73(4), TSC2(6)	9953517	194	71	183	90	112	7	10	27	38	0	0.287	1.000	1.000
195	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(6), AGTR2(2), ATP8A1(13), AVPR1A(2), AVPR1B(5), BDKRB1(4), BDKRB2(2), BRS3(2), C3AR1(2), CCKAR(8), CCKBR(8), CCR1(5), CCR10(1), CCR2(6), CCR3(7), CCR4(4), CCR5(4), CCR6(1), CCR7(2), CCR8(2), CX3CR1(9), CXCR3(2), CXCR6(4), EDNRA(3), EDNRB(3), FPR1(15), FSHR(9), GALR1(3), GALT(2), GHSR(5), GNB2L1(1), GNRHR(2), GPR77(3), GRPR(2), LHCGR(10), MC2R(2), MC3R(6), MC4R(1), MC5R(4), NMBR(2), NPY1R(10), NPY2R(8), NPY5R(11), NTSR1(3), NTSR2(1), OPRK1(14), OPRL1(3), OPRM1(4), OXTR(3), PPYR1(9), SSTR1(5), SSTR2(1), SSTR3(9), SSTR4(1), TACR1(3), TACR2(3), TACR3(16), TRHR(9), TSHR(6)	8037551	293	71	287	217	205	24	13	27	24	0	0.0666	1.000	1.000
196	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(1), ACVR1B(3), ACVR1C(7), ACVR2A(1), ACVR2B(1), ACVRL1(4), AMHR2(7), BMP2(3), BMP4(1), BMP5(9), BMP6(6), BMP7(2), BMPR1A(1), BMPR1B(2), BMPR2(3), CHRD(8), COMP(4), CREBBP(12), CUL1(2), DCN(11), EP300(7), FST(1), GDF5(8), GDF6(1), GDF7(2), ID2(2), IFNG(2), INHBA(10), INHBB(4), INHBC(6), INHBE(1), LEFTY1(2), LEFTY2(1), LTBP1(23), MAPK1(2), MAPK3(1), MYC(2), NODAL(1), PITX2(1), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(2), PPP2R2C(4), RBL1(4), RBL2(2), ROCK1(2), ROCK2(4), RPS6KB1(1), RPS6KB2(2), SMAD1(4), SMAD2(1), SMAD5(3), SMAD6(4), SMAD9(5), SMURF1(1), SMURF2(3), SP1(3), TGFB2(1), TGFB3(1), TGFBR2(5), THBS1(15), THBS2(5), THBS3(7), THBS4(7), TNF(1), ZFYVE16(2), ZFYVE9(4)	15245536	266	70	263	154	177	28	11	22	28	0	0.844	1.000	1.000
197	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(29), COL4A2(20), COL4A3(16), COL4A4(50), COL4A5(32), COL4A6(21), F10(2), F11(8), F12(1), F2(6), F2R(3), F5(19), F8(21), F9(6), FGA(19), FGB(6), FGG(3), KLKB1(15), PROC(7), PROS1(8), SERPINC1(5), SERPING1(7)	6810064	304	70	296	96	243	16	11	20	14	0	0.157	1.000	1.000
198	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(4), AKR1D1(9), ARSD(1), ARSE(2), CARM1(2), CYP11B1(7), CYP11B2(8), CYP19A1(5), HEMK1(1), HSD11B1(6), HSD17B2(6), HSD17B3(5), HSD3B1(1), HSD3B2(9), LCMT1(3), METTL2B(5), PRMT2(1), PRMT3(3), PRMT5(3), PRMT6(1), PRMT7(1), PRMT8(7), SRD5A1(2), SRD5A2(4), STS(1), SULT1E1(7), SULT2A1(4), SULT2B1(5), UGT1A1(1), UGT1A10(10), UGT1A3(6), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(7), UGT1A8(2), UGT1A9(5), UGT2A1(8), UGT2A3(14), UGT2B10(17), UGT2B11(10), UGT2B15(16), UGT2B28(14), UGT2B4(18), UGT2B7(8)	7634744	260	69	250	114	181	23	11	15	30	0	0.00247	1.000	1.000
199	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), AGK(1), AGPAT2(3), AGPAT3(3), AGPAT4(4), AKR1B1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2), CEL(4), DAK(2), DGAT2(2), DGKA(1), DGKB(14), DGKD(3), DGKE(5), DGKG(8), DGKH(6), DGKI(12), DGKQ(2), DGKZ(6), GK(4), GK2(13), GLB1(5), GPAM(5), LCT(24), LIPC(5), LIPF(6), LIPG(5), LPL(2), MGLL(3), PNLIP(4), PNLIPRP1(8), PNLIPRP2(1), PNPLA3(1), PPAP2B(4), PPAP2C(5)	9043877	251	69	238	117	180	23	10	20	18	0	0.0175	1.000	1.000
200	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(2), ACADL(2), ACADM(3), ACADSB(3), ACAT2(1), ACOX1(3), ACOX3(5), ACSL1(2), ACSL3(3), ACSL5(8), ACSL6(4), ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2), CPT1A(6), CPT1B(4), CPT1C(11), CPT2(1), CYP4A11(12), CYP4A22(16), DCI(2), EHHADH(5), GCDH(3), HADHA(7), HADHB(2), HSD17B10(1), HSD17B4(3), PECI(1)	7564273	188	68	178	85	137	16	10	12	12	1	0.0280	1.000	1.000
201	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(1), CREBBP(12), DLL1(2), DLL3(4), DLL4(4), DTX1(5), DTX2(3), DTX3(1), DTX3L(5), DTX4(2), DVL2(2), DVL3(4), EP300(7), HDAC1(1), HES1(1), JAG1(5), JAG2(4), LFNG(3), MAML1(2), MAML2(2), MAML3(6), MFNG(5), NCOR2(14), NCSTN(2), NOTCH1(3), NOTCH2(22), NOTCH3(14), NOTCH4(35), NUMB(2), NUMBL(2), PSEN2(2), PTCRA(1), RBPJ(2), RBPJL(1), SNW1(2)	10547293	183	68	183	97	104	23	6	34	16	0	0.718	1.000	1.000
202	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(1), CDC40(3), CLK2(2), COL2A1(17), CPSF1(3), CPSF2(1), CPSF3(2), CSTF1(5), CSTF2(2), CSTF2T(2), CSTF3(3), DDIT3(1), DDX20(6), DHX15(1), DHX16(4), DHX38(5), DHX8(4), DHX9(4), DICER1(11), DNAJC8(2), GIPC1(2), LOC440563(12), LSM7(1), METTL3(1), NCBP1(1), NONO(4), NUDT21(2), NXF1(2), PABPN1(1), PAPOLA(3), POLR2A(8), PRPF18(2), PRPF3(1), PRPF4(3), PRPF4B(2), PRPF8(9), PSKH1(2), PTBP1(1), PTBP2(4), RBM17(1), RBM5(4), RNGTT(1), RNMT(6), SF3A1(4), SF3A2(2), SF3A3(2), SF3B1(8), SF3B2(6), SF3B4(4), SF4(3), SFRS12(2), SFRS14(6), SFRS16(5), SFRS5(1), SFRS6(1), SFRS8(1), SFRS9(2), SNRPB(4), SNRPB2(1), SNRPN(3), SNURF(1), SPOP(1), SRPK1(4), SRPK2(2), SRRM1(5), SUPT5H(4), XRN2(3)	16370387	227	68	227	87	156	16	12	26	17	0	0.0725	1.000	1.000
203	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ABP1(10), ACAT2(1), ACMSD(5), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH9A1(2), AOC2(5), AOC3(5), AOX1(13), ASMT(3), CAT(3), CYP19A1(5), CYP1A1(8), CYP1A2(8), CYP2A13(4), CYP2A6(7), CYP2A7(5), CYP2B6(9), CYP2C18(17), CYP2C19(25), CYP2C8(18), CYP2C9(24), CYP2D6(1), CYP2E1(8), CYP2F1(6), CYP2J2(3), CYP3A4(12), CYP3A5(4), CYP3A7(12), CYP4B1(8), CYP4F8(7), CYP51A1(1), DDC(5), EHHADH(5), GCDH(3), HAAO(1), HADHA(7), KMO(4), KYNU(5), MAOA(2), MAOB(7), TDO2(2), TPH1(1), WARS(3), WARS2(1)	8409520	307	68	296	180	247	17	12	16	15	0	0.116	1.000	1.000
204	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(10), ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), ALDH1A3(2), ALDH3A1(3), ALDH3B1(1), ALDH3B2(4), AOC2(5), AOC3(5), AOX1(13), CARM1(2), COMT(1), DBH(5), DCT(1), DDC(5), ECH1(1), FAH(4), GOT1(4), GOT2(2), HEMK1(1), HGD(10), HPD(2), LCMT1(3), MAOA(2), MAOB(7), METTL2B(5), MYST3(9), MYST4(11), NAT6(2), PNMT(3), PNPLA3(1), PRMT2(1), PRMT3(3), PRMT5(3), PRMT6(1), PRMT7(1), PRMT8(7), SH3GLB1(1), TAT(10), TH(6), TPO(28), TYR(2), TYRP1(3)	9122120	254	67	243	135	194	21	14	13	12	0	0.176	1.000	1.000
205	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(1), AKT2(6), AKT3(2), CDKN2A(16), CREB5(7), ERBB4(26), F2RL2(3), GAB1(3), GRB2(2), GSK3B(1), IFI27(2), IGF1(6), IGFBP1(1), INPPL1(9), IRS1(2), IRS4(5), MET(7), MYC(2), NOLC1(2), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PAK7(27), PARD3(9), PDK1(1), PIK3CA(2), PIK3CD(2), PPP1R13B(3), PREX1(1), PTEN(11), PTK2(2), PTPN1(1), RPS6KA1(2), RPS6KA2(4), RPS6KB1(1), SFN(1), SLC2A4(2), SOS1(4), SOS2(3), TSC1(3), TSC2(6), YWHAG(1), YWHAQ(1)	11862825	204	67	196	104	124	17	11	22	30	0	0.484	1.000	1.000
206	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(10), CCKBR(8), CCR2(6), CCR3(7), CCR5(4), CELSR1(18), CELSR2(14), CELSR3(14), CHRM2(7), CHRM3(10), CXCR3(2), DRD4(1), EDNRA(3), EMR2(1), EMR3(14), F2R(3), FSHR(9), GHRHR(4), GNRHR(2), GPR116(20), GPR132(1), GPR133(6), GPR143(2), GPR55(4), GPR56(3), GPR77(3), GPR84(4), GRM1(7), GRPR(2), HRH4(4), LGR6(9), LPHN2(22), LPHN3(8), NTSR1(3), OR2M4(8), OR8G2(5), P2RY13(2), PTGFR(12), SMO(4), SSTR2(1), TAAR5(1), TSHR(6)	10199852	274	66	267	193	189	21	11	32	21	0	0.449	1.000	1.000
207	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(3), ADCY4(1), ADCY6(5), ADCY8(26), CACNA1A(19), CACNA1B(18), GNAS(12), GNAT3(3), GNB3(5), GRM4(13), ITPR3(4), KCNB1(13), PDE1A(21), PLCB2(4), PRKACA(2), PRKACB(2), PRKACG(5), PRKX(1), SCNN1A(5), SCNN1B(10), SCNN1G(16), TAS1R1(5), TAS1R2(12), TAS1R3(1), TAS2R1(5), TAS2R10(4), TAS2R13(2), TAS2R14(1), TAS2R16(3), TAS2R38(11), TAS2R39(7), TAS2R4(1), TAS2R40(3), TAS2R41(6), TAS2R46(1), TAS2R5(1), TAS2R60(11), TAS2R7(2), TAS2R8(3), TAS2R9(2), TRPM5(7)	8681102	276	66	265	232	195	16	9	32	24	0	0.890	1.000	1.000
208	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(1), AKT2(6), AKT3(2), BCR(6), BTK(6), CD19(3), CDKN2A(16), DAPP1(2), FLOT1(1), GAB1(3), ITPR1(16), ITPR2(10), ITPR3(4), LYN(1), NR0B2(5), PDK1(1), PIK3CA(2), PITX2(1), PLCG2(9), PPP1R13B(3), PREX1(1), PTEN(11), PTPRC(18), RPS6KA1(2), RPS6KA2(4), RPS6KB1(1), SAG(4), SYK(9), TEC(6), VAV1(12)	8446171	166	66	156	93	101	14	9	14	28	0	0.411	1.000	1.000
209	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(3), BCL2(2), CABIN1(1), CALM2(1), CAMK2B(1), CAMK4(8), CD3E(2), CD69(3), CDKN1A(1), CNR1(7), CREBBP(12), CSF2(2), CSNK2B(1), CTLA4(1), EGR2(3), EGR3(1), EP300(7), FCER1A(6), FCGR3A(3), FOS(1), GATA3(8), GATA4(1), GRLF1(3), GSK3B(1), ICOS(2), IFNB1(4), IFNG(2), IL10(1), IL13(2), IL1B(2), IL2(4), IL2RA(4), IL3(2), IL4(1), IL8(1), ITK(15), KPNA5(1), MAP2K7(2), MAPK14(4), MAPK9(1), MEF2A(2), MEF2B(2), MEF2D(2), MYF5(7), NCK2(3), NFAT5(3), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), NFKB2(3), NFKBIB(1), NPPB(4), NUP214(7), P2RX7(3), PAK1(2), PPIA(1), PPP3CB(1), PTPRC(18), RELA(1), SFN(1), SLA(1), SP1(3), SP3(1), TNF(1), TRAF2(1), TRPV6(17), VAV1(12), VAV2(3), VAV3(5), XPO5(6)	13981478	259	65	250	131	193	21	8	17	20	0	0.163	1.000	1.000
210	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(7), CAD(11), CANT1(4), CDA(2), CTPS(1), CTPS2(2), DCTD(1), DHODH(1), DPYD(33), DPYS(13), ENTPD1(5), ENTPD3(3), ENTPD4(2), ENTPD6(2), ENTPD8(1), NME7(4), NT5C1B(16), NT5C3(2), NT5E(3), NT5M(1), PNPT1(1), POLA1(1), POLA2(6), POLD1(2), POLD2(1), POLD3(3), POLE(9), POLE2(1), POLR1A(7), POLR1B(4), POLR1C(1), POLR2A(8), POLR2B(10), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2L(1), POLR3A(2), POLR3B(10), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(8), RRM1(2), RRM2B(1), TXNRD1(1), TXNRD2(1), TYMS(1), UCK1(2), UMPS(1), UPB1(3), UPP2(4)	12448382	213	64	206	104	146	20	9	21	17	0	0.121	1.000	1.000
211	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(3), BAX(1), BTK(6), CAD(11), CASP10(3), CASP8(1), CASP8AP2(3), CDK2AP1(1), CSNK1A1(1), DAXX(4), DEDD(1), DEDD2(3), DFFA(1), DIABLO(1), EGFR(13), EPHB2(15), FAF1(3), FAIM2(4), HSPB1(1), IL1A(2), IL8(1), MAP2K4(3), MAP2K7(2), MAP3K5(9), MAPK1(2), MAPK10(5), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1), MET(7), NFAT5(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(1), NFKBIL1(3), NR0B2(5), PTPN13(7), RALBP1(1), RIPK1(1), ROCK1(2), SMPD1(1), TNFRSF6B(1), TP53(20), TPX2(7), TRAF2(1), TUFM(2)	11162946	179	64	175	101	119	10	11	20	19	0	0.663	1.000	1.000
212	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(3), AGT(3), AKT1(1), CALM2(1), CAMK1(4), CAMK1G(8), CAMK4(8), CREBBP(12), CSNK1A1(1), EDN1(6), F2(6), FKBP1A(2), GATA4(1), GSK3B(1), HAND2(3), IGF1(6), LIF(1), MAP2K1(3), MAPK1(2), MAPK14(4), MAPK3(1), MEF2C(2), MYH2(38), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), NPPA(1), PIK3CA(2), PIK3R1(2), PPP3CA(4), PPP3CB(1), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), RAF1(2), RPS6KB1(1), SYT1(11)	7806324	175	63	170	102	138	12	6	10	9	0	0.579	1.000	1.000
213	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(2), ACP2(2), ACP5(2), ACPP(4), ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), CYP19A1(5), CYP1A1(8), CYP1A2(8), CYP2A13(4), CYP2A6(7), CYP2A7(5), CYP2B6(9), CYP2C18(17), CYP2C19(25), CYP2C8(18), CYP2C9(24), CYP2D6(1), CYP2E1(8), CYP2F1(6), CYP2J2(3), CYP3A4(12), CYP3A5(4), CYP3A7(12), CYP4B1(8), CYP4F8(7), CYP51A1(1), PON1(8)	4457728	227	62	217	137	188	8	8	8	15	0	0.0467	1.000	1.000
214	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(4), CD4(3), CD74(3), CD8A(1), CD8B(4), CIITA(10), CTSS(3), HLA-A(1), HLA-B(4), HLA-C(1), HLA-DMA(2), HLA-DMB(3), HLA-DOA(3), HLA-DOB(1), HLA-DQA1(3), HLA-DQA2(2), HLA-DQB1(3), HLA-DRA(5), HLA-F(4), HLA-G(3), HSP90AA1(2), HSP90AB1(3), HSPA5(4), IFNA10(1), IFNA14(4), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(6), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(2), KIR2DL1(12), KIR2DL3(4), KIR2DL4(3), KIR2DS4(12), KIR3DL1(14), KIR3DL2(2), KIR3DL3(1), KLRC1(2), KLRC2(1), KLRC3(5), KLRC4(3), KLRD1(4), LGMN(4), LTA(2), NFYA(1), NFYB(1), PDIA3(2), PSME2(4), RFX5(2), RFXANK(1), TAP1(1), TAP2(11), TAPBP(1)	7079916	191	62	187	104	131	18	7	14	21	0	0.211	1.000	1.000
215	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(12), ACSL1(2), ACSL3(3), ACSL5(8), ACSL6(4), ADIPOQ(1), ADIPOR1(3), AKT1(1), AKT2(6), AKT3(2), CAMKK1(1), CAMKK2(3), CD36(3), CHUK(1), CPT1A(6), CPT1B(4), CPT1C(11), CPT2(1), G6PC(4), G6PC2(2), IKBKB(2), IRS1(2), IRS4(5), JAK1(4), JAK2(6), JAK3(5), LEP(1), LEPR(10), MAPK10(5), MAPK9(1), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(1), NPY(2), PCK1(15), PCK2(2), POMC(3), PPARA(3), PPARGC1A(14), PRKAA1(1), PRKAA2(15), PRKAB2(1), PRKAG1(1), PRKAG2(2), PRKAG3(5), PRKCQ(12), PTPN11(3), RELA(1), RXRA(1), RXRB(1), RXRG(1), SLC2A1(3), SLC2A4(2), SOCS3(2), STAT3(6), STK11(2), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(1), TYK2(3)	12748424	231	62	226	142	159	26	13	15	18	0	0.669	1.000	1.000
216	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(2), AKT1(1), AKT2(6), AKT3(2), ANGPTL2(2), ARHGAP1(1), ARHGAP4(1), ARHGEF11(9), BTK(6), GDI2(1), INPPL1(9), ITPR1(16), ITPR2(10), ITPR3(4), LIMK1(4), MYLK(17), MYLK2(4), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PAK7(27), PDK1(1), PIK3CA(2), PIK3CD(2), PIK3CG(12), PIK3R1(2), PITX2(1), PPP1R13B(3), PTEN(11), RHO(2), ROCK1(2), ROCK2(4), SAG(4), WASF1(1), WASL(1)	10719997	184	62	181	87	122	17	10	20	15	0	0.101	1.000	1.000
217	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(5), ABP1(10), ACADL(2), ACADM(3), ACADSB(3), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH9A1(2), AOC2(5), AOC3(5), CNDP1(7), DPYD(33), DPYS(13), EHHADH(5), GAD1(6), GAD2(3), HADHA(7), MLYCD(2), SMS(1), UPB1(3)	4470969	136	61	131	56	97	10	8	13	8	0	0.0173	1.000	1.000
218	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), AGPAT2(3), AGPAT3(3), AGPAT4(4), AKR1B1(2), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH9A1(2), CEL(4), DGKA(1), DGKB(14), DGKD(3), DGKE(5), DGKG(8), DGKH(6), DGKQ(2), DGKZ(6), GK(4), GLB1(5), LCT(24), LIPC(5), LIPF(6), LIPG(5), LPL(2), PNLIP(4), PNLIPRP1(8), PNLIPRP2(1), PPAP2B(4), PPAP2C(5)	7417786	221	61	209	101	159	22	9	16	15	0	0.0131	1.000	1.000
219	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(6), ALOX12(2), ALOX12B(4), ALOX15(4), ALOX15B(5), ALOX5(6), CYP2B6(9), CYP2C18(17), CYP2C19(25), CYP2C8(18), CYP2C9(24), CYP2E1(8), CYP2J2(3), CYP4A11(12), CYP4A22(16), CYP4F2(6), CYP4F3(11), EPHX2(4), GGT1(3), GPX1(2), GPX3(2), GPX5(6), GPX6(5), LTA4H(2), PLA2G12B(3), PLA2G2A(1), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(12), PLA2G4A(7), PLA2G6(7), PTGDS(1), PTGIS(8), PTGS1(12), PTGS2(6), TBXAS1(7)	5928424	273	61	265	185	216	17	5	18	16	1	0.463	1.000	1.000
220	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(11), AXIN1(6), CCND2(3), CSNK1E(3), CTNNB1(5), DVL2(2), DVL3(4), FBXW2(1), FZD1(1), FZD10(1), FZD2(2), FZD5(1), FZD6(2), FZD7(2), FZD8(3), GSK3B(1), JUN(1), LDLR(9), MAPK10(5), MAPK9(1), MYC(2), PAFAH1B1(2), PLAU(2), PPP2R5C(2), PPP2R5E(2), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCH(2), PRKCI(4), PRKCQ(12), PRKCZ(1), PRKD1(1), RAC1(7), SFRP4(3), WNT1(1), WNT10A(4), WNT10B(3), WNT11(2), WNT16(1), WNT2(5), WNT2B(1), WNT3(3), WNT4(2), WNT5A(4), WNT5B(2), WNT6(2), WNT7A(9), WNT7B(2)	9143672	164	61	159	96	107	15	3	19	20	0	0.571	1.000	1.000
221	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(3), AGT(3), AGTR1(6), AGTR2(2), CMA1(3), COL4A1(29), COL4A2(20), COL4A3(16), COL4A4(50), COL4A5(32), COL4A6(21), REN(7)	3866208	192	60	187	63	163	9	4	7	9	0	0.764	1.000	1.000
222	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP1(2), INPP4A(4), INPP5A(2), INPPL1(9), ITPKB(4), MIOX(3), OCRL(2), PIK3C2A(3), PIK3C2B(7), PIK3C2G(20), PIK3CA(2), PIK3CB(10), PIK3CG(12), PLCB1(29), PLCB2(4), PLCB3(2), PLCB4(32), PLCD1(2), PLCG1(4), PLCG2(9)	6844179	163	60	155	78	115	6	8	15	19	0	0.120	1.000	1.000
223	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(1), ATF2(5), DUSP10(6), DUSP4(1), DUSP8(1), GAB1(3), GCK(8), IL1R1(6), JUN(1), MAP2K4(3), MAP2K5(2), MAP2K7(2), MAP3K10(5), MAP3K11(3), MAP3K12(2), MAP3K13(5), MAP3K2(2), MAP3K3(3), MAP3K4(9), MAP3K5(9), MAP3K9(13), MAPK10(5), MAPK7(2), MAPK9(1), NFATC3(5), NR2C2(2), PAPPA(35), TP53(20), TRAF6(2), ZAK(4)	7715754	166	60	164	65	119	14	5	14	14	0	0.0731	1.000	1.000
224	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(10), ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), ALDH1A3(2), ALDH3A1(3), ALDH3B1(1), ALDH3B2(4), AOC2(5), AOC3(5), AOX1(13), COMT(1), DBH(5), DCT(1), DDC(5), FAH(4), GOT1(4), GOT2(2), HGD(10), HPD(2), MAOA(2), MAOB(7), PNMT(3), TAT(10), TH(6), TPO(28), TYR(2)	4848619	199	60	190	103	158	13	12	8	8	0	0.0347	1.000	1.000
225	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS2(3), ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH3B1(1), ALDH3B2(4), ALDH7A1(2), ALDH9A1(2), ALDOA(1), ALDOB(5), ALDOC(1), BPGM(1), DLAT(2), ENO1(2), ENO3(1), FBP1(1), G6PC(4), G6PC2(2), GALM(2), GCK(8), GPI(2), HK1(1), HK2(4), HK3(10), LDHA(2), LDHAL6B(5), LDHC(1), PDHA1(1), PDHA2(7), PDHB(1), PFKL(2), PGK1(1), PGK2(15), PGM1(2), PGM3(1), PKLR(6), PKM2(4)	8945952	181	59	171	89	137	11	8	9	16	0	0.0129	1.000	1.000
226	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(5), ABP1(10), ACADM(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2), AOC2(5), AOC3(5), CNDP1(7), DPYD(33), DPYS(13), EHHADH(5), GAD1(6), GAD2(3), HADHA(7), HIBCH(1), MLYCD(2), SMS(1), UPB1(3)	4158758	123	59	118	55	89	8	7	12	7	0	0.0507	1.000	1.000
227	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(3), ACTB(3), ACTG1(3), ARHGEF2(7), CD14(3), CDH1(4), CLDN1(5), CTNNB1(5), CTTN(1), EZR(1), FYN(4), HCLS1(7), ITGB1(3), KRT18(2), LY96(3), NCK2(3), NCL(3), OCLN(2), PRKCA(5), ROCK1(2), ROCK2(4), TLR4(21), TLR5(11), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(10), TUBA3D(5), TUBA3E(1), TUBA4A(3), TUBA8(1), TUBAL3(8), TUBB1(2), TUBB2A(1), TUBB3(3), TUBB4(1), TUBB4Q(4), TUBB6(5), TUBB8(6), WAS(4), WASL(1), YWHAQ(1)	8057064	165	59	160	70	118	15	5	16	11	0	0.0129	1.000	1.000
228	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(3), ACTB(3), ACTG1(3), ARHGEF2(7), CD14(3), CDH1(4), CLDN1(5), CTNNB1(5), CTTN(1), EZR(1), FYN(4), HCLS1(7), ITGB1(3), KRT18(2), LY96(3), NCK2(3), NCL(3), OCLN(2), PRKCA(5), ROCK1(2), ROCK2(4), TLR4(21), TLR5(11), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(10), TUBA3D(5), TUBA3E(1), TUBA4A(3), TUBA8(1), TUBAL3(8), TUBB1(2), TUBB2A(1), TUBB3(3), TUBB4(1), TUBB4Q(4), TUBB6(5), TUBB8(6), WAS(4), WASL(1), YWHAQ(1)	8057064	165	59	160	70	118	15	5	16	11	0	0.0129	1.000	1.000
229	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(3), AKT1(1), BDKRB2(2), CALM2(1), CAV1(1), CHRM1(4), CHRNA1(1), FLT1(17), FLT4(16), KDR(22), NOS3(11), PDE2A(7), PDE3A(13), PDE3B(3), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKG1(5), PRKG2(8), RYR2(42), SLC7A1(1), SYT1(11), TNNI1(1)	6246351	183	59	174	108	138	15	5	11	13	1	0.310	1.000	1.000
230	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(5), ALOX15(4), ALOX5(6), CYP1A2(8), CYP2C18(17), CYP2C19(25), CYP2C8(18), CYP2C9(24), CYP2E1(8), CYP2J2(3), CYP3A4(12), CYP3A43(8), CYP3A5(4), CYP3A7(12), PLA2G12B(3), PLA2G2A(1), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(12), PLA2G4A(7), PLA2G6(7), RDH12(1), RDH13(3)	3660662	197	58	191	113	159	8	6	11	13	0	0.103	1.000	1.000
231	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(3), ADAM17(1), ATP6V0A1(3), ATP6V0A4(11), ATP6V0D2(6), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(6), ATP6V1E2(1), ATP6V1F(1), ATP6V1G3(5), ATP6V1H(4), CHUK(1), CSK(1), EGFR(13), F11R(4), GIT1(4), IGSF5(5), IKBKB(2), IL8(1), JAM2(6), JAM3(1), JUN(1), LYN(1), MAP2K4(3), MAP3K14(1), MAPK10(5), MAPK11(1), MAPK13(2), MAPK14(4), MAPK9(1), MET(7), NFKB1(1), NFKB2(3), NFKBIA(1), NOD1(2), PAK1(2), PLCG1(4), PLCG2(9), PTPN11(3), PTPRZ1(13), RAC1(7), RELA(1), TCIRG1(2), TJP1(5)	10822309	162	58	158	115	112	13	5	18	14	0	0.970	1.000	1.000
232	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(8), BMPR1B(2), CCND2(3), CDK4(2), DAZL(3), DMC1(2), EGR1(1), ESR2(4), FSHR(9), GJA4(3), INHA(3), LHCGR(10), MLH1(5), MSH5(5), NCOR1(12), NR5A1(6), NRIP1(5), PGR(10), PRLR(17), PTGER2(4), SMPD1(1), VDR(2), ZP2(9)	5354401	126	58	115	67	90	6	3	13	14	0	0.629	1.000	1.000
233	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(1), AKT2(6), AKT3(2), BRD4(13), CBL(4), CDKN2A(16), F2RL2(3), FLOT1(1), GRB2(2), GSK3B(1), IGFBP1(1), INPPL1(9), IRS1(2), IRS4(5), LNPEP(9), MAPK1(2), MAPK3(1), PARD3(9), PDK1(1), PIK3CA(2), PIK3CD(2), PIK3R1(2), PPYR1(9), PTEN(11), PTPN1(1), RAF1(2), RPS6KA1(2), RPS6KA2(4), RPS6KB1(1), SERPINB6(1), SFN(1), SLC2A4(2), SORBS1(6), SOS1(4), SOS2(3), YWHAG(1), YWHAQ(1)	9162023	143	58	139	70	77	15	9	17	25	0	0.495	1.000	1.000
234	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(2), F11(8), F12(1), F13B(13), F2(6), F5(19), F7(2), F8(21), F9(6), FGA(19), FGB(6), FGG(3), LPA(24), PLAT(2), PLAU(2), PLG(14), SERPINB2(7), SERPINE1(2), SERPINF2(3), VWF(28)	5379988	188	57	184	87	136	14	10	10	17	1	0.214	1.000	1.000
235	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH3B1(1), ALDH3B2(4), ALDH9A1(2), ALDOA(1), ALDOB(5), ALDOC(1), BPGM(1), DLAT(2), ENO1(2), ENO3(1), FBP1(1), G6PC(4), GCK(8), GPI(2), HK1(1), HK2(4), HK3(10), LDHA(2), LDHC(1), PDHA1(1), PDHA2(7), PDHB(1), PGK1(1), PGM1(2), PGM3(1), PKLR(6), PKM2(4)	7510011	161	57	154	73	117	13	7	10	14	0	0.00678	1.000	1.000
236	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH3B1(1), ALDH3B2(4), ALDH9A1(2), ALDOA(1), ALDOB(5), ALDOC(1), BPGM(1), DLAT(2), ENO1(2), ENO3(1), FBP1(1), G6PC(4), GCK(8), GPI(2), HK1(1), HK2(4), HK3(10), LDHA(2), LDHC(1), PDHA1(1), PDHA2(7), PDHB(1), PGK1(1), PGM1(2), PGM3(1), PKLR(6), PKM2(4)	7510011	161	57	154	73	117	13	7	10	14	0	0.00678	1.000	1.000
237	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(3), BMP4(1), BMP5(9), BMP6(6), BMP7(2), BTRC(3), CSNK1A1(1), CSNK1A1L(3), CSNK1D(1), CSNK1E(3), CSNK1G1(1), CSNK1G2(2), FBXW11(4), GLI1(7), GLI2(20), GLI3(7), GSK3B(1), HHIP(13), IHH(2), LRP2(49), PRKACA(2), PRKACB(2), PRKACG(5), PRKX(1), PTCH1(3), PTCH2(9), SHH(2), SMO(4), STK36(9), SUFU(1), WNT1(1), WNT10A(4), WNT10B(3), WNT11(2), WNT16(1), WNT2(5), WNT2B(1), WNT3(3), WNT3A(5), WNT4(2), WNT5A(4), WNT5B(2), WNT6(2), WNT7A(9), WNT7B(2), WNT8A(4), WNT8B(4), WNT9A(1), WNT9B(3), ZIC2(1)	9238364	235	57	225	125	170	22	6	18	19	0	0.177	1.000	1.000
238	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(1), AKT2(6), AKT3(2), BCL2(2), BCR(6), BLNK(10), BTK(6), CD19(3), CD22(15), CD81(2), CR2(16), CSK(1), DAG1(3), FLOT1(1), GRB2(2), GSK3B(1), INPP5D(19), ITPR1(16), ITPR2(10), ITPR3(4), LYN(1), MAP4K1(3), MAPK1(2), MAPK3(1), NFATC1(9), NFATC2(4), NR0B2(5), PDK1(1), PIK3CA(2), PIK3CD(2), PIK3R1(2), PLCG2(9), PPP1R13B(3), PPP3CA(4), PPP3CB(1), PTPRC(18), RAF1(2), SOS1(4), SOS2(3), SYK(9), VAV1(12)	11327445	223	57	217	112	157	22	11	14	19	0	0.0774	1.000	1.000
239	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(29), COL4A2(20), COL4A3(16), COL4A4(50), COL4A5(32), COL4A6(21), P4HB(2), SLC23A1(2), SLC23A2(1), SLC2A1(3), SLC2A3(4)	3820501	180	57	175	52	152	7	7	7	7	0	0.269	1.000	1.000
240	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM2(1), CAMK1(4), CAMK1G(8), FPR1(15), GNA15(2), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K6(2), MAPK1(2), MAPK14(4), MAPK3(1), NCF2(4), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), NFKB1(1), NFKBIA(1), PAK1(2), PIK3C2G(20), PLCB1(29), PPP3CA(4), PPP3CB(1), RAC1(7), RAF1(2), RELA(1), SYT1(11)	5835018	152	56	144	73	118	9	5	9	11	0	0.191	1.000	1.000
241	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(11), CANT1(4), CDA(2), CTPS(1), CTPS2(2), DCTD(1), DHODH(1), DPYD(33), DPYS(13), ENTPD1(5), NT5E(3), NT5M(1), POLD1(2), POLD2(1), POLE(9), POLG(4), POLL(6), POLQ(12), POLR1B(4), POLR2A(8), POLR2B(10), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2L(1), POLRMT(1), RRM1(2), TXNRD1(1), TYMS(1), UCK1(2), UMPS(1), UNG(2), UPB1(3)	8816508	152	56	146	66	106	11	7	15	13	0	0.0321	1.000	1.000
242	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(28), B3GALT4(1), CDR1(3), DGKI(12), IL6ST(4), MRPL19(1), PIGK(3), RPL10(2), RPL11(1), RPL14(1), RPL15(2), RPL18(2), RPL18A(1), RPL21(1), RPL22(1), RPL26(1), RPL27(2), RPL27A(1), RPL3(1), RPL30(1), RPL38(1), RPL3L(3), RPL4(4), RPL5(3), RPL7(2), RPL7A(1), RPLP0(1), RPS10(1), RPS13(1), RPS2(1), RPS20(1), RPS24(1), RPS27(1), RPS29(1), RPS5(1), RPS6(1), RPS6KA1(2), RPS6KA2(4), RPS6KA6(3), RPS6KB1(1), RPS6KB2(2), RPS7(1), RPSA(1), SLC36A2(5), TBC1D10C(3), TSPAN9(1), UBC(3)	7964926	119	56	118	82	73	14	6	16	10	0	0.946	1.000	1.000
243	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(3), ACTG2(1), ACTR2(2), AKT1(1), ANGPTL2(2), FLNA(5), FLNC(31), FSCN1(4), FSCN2(1), FSCN3(7), GDI2(1), LIMK1(4), MYH2(38), MYLK(17), MYLK2(4), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PAK7(27), RHO(2), ROCK1(2), ROCK2(4), WASF1(1), WASL(1)	7318142	172	56	165	94	127	24	4	10	7	0	0.121	1.000	1.000
244	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(4), CD3D(4), CSK(1), CTLA4(1), DAG1(3), EPHB2(15), FBXW7(7), GRAP2(1), GRB2(2), ITK(15), ITPKB(4), LCK(4), LCP2(5), MAPK1(2), NFAT5(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(1), NFKBIL1(3), PAK1(2), PAK2(2), PAK3(5), PAK4(3), PAK6(2), PAK7(27), PLCG1(4), PTPRC(18), RAF1(2), RASGRP1(6), RASGRP2(2), RASGRP3(7), RASGRP4(7), SOS1(4), SOS2(3), VAV1(12), ZAP70(4)	8492419	190	56	183	98	133	12	9	21	15	0	0.351	1.000	1.000
245	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(3), BAX(1), BCL2(2), BCL2L11(2), BIRC2(4), BIRC3(5), BNIP3L(2), CASP1(3), CASP10(3), CASP2(1), CASP4(1), CASP7(3), CASP8(1), CASP9(2), CHUK(1), CYCS(1), DFFA(1), DFFB(2), FAS(3), FASLG(10), GZMB(1), HELLS(3), IKBKB(2), IRF2(3), IRF3(1), IRF4(1), IRF5(2), IRF6(5), IRF7(3), JUN(1), LTA(2), MAP2K4(3), MAPK10(5), MDM2(2), MYC(2), NFKB1(1), NFKBIA(1), NFKBIB(1), PLEKHG5(8), PRF1(5), RELA(1), RIPK1(1), TNF(1), TNFRSF10B(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(6), TNFRSF25(3), TNFSF10(5), TP53(20), TP73(4), TRAF1(4), TRAF2(1), TRAF3(3)	8774440	156	55	154	83	105	12	10	13	16	0	0.411	1.000	1.000
246	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(10), AGMAT(2), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH4A1(4), ALDH9A1(2), AOC2(5), AOC3(5), ASL(2), CKM(1), CKMT1A(1), CKMT2(5), CPS1(12), DAO(6), GAMT(2), GATM(1), GLUD1(1), GOT1(4), GOT2(2), MAOA(2), MAOB(7), NOS1(32), NOS3(11), OAT(1), ODC1(2), OTC(2), P4HA1(6), P4HA2(4), P4HA3(7), P4HB(2), RARS(4), SMS(1)	6748735	167	55	164	93	119	17	11	7	13	0	0.190	1.000	1.000
247	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(3), ALAS2(2), BLVRA(1), BLVRB(1), COX10(3), COX15(1), CP(8), CPOX(2), EPRS(4), FECH(1), FTH1(2), FTMT(3), GUSB(2), HCCS(1), HMBS(1), HMOX1(1), MMAB(2), PPOX(2), UGT1A1(1), UGT1A10(10), UGT1A3(6), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(7), UGT1A8(2), UGT1A9(5), UGT2A1(8), UGT2A3(14), UGT2B10(17), UGT2B11(10), UGT2B15(16), UGT2B28(14), UGT2B4(18), UGT2B7(8), UROS(1)	6457174	188	55	182	74	133	16	7	11	21	0	0.00593	1.000	1.000
248	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(2), ABO(4), B3GALNT1(4), B3GALT1(8), B3GALT2(1), B3GALT4(1), B3GALT5(1), B3GNT1(1), B3GNT2(2), B3GNT3(3), B3GNT4(2), B3GNT5(1), B4GALNT1(1), B4GALT2(2), B4GALT3(1), B4GALT6(1), FUT1(3), FUT2(1), FUT3(3), FUT4(1), FUT5(6), FUT6(1), FUT7(1), FUT9(13), GBGT1(1), PIGB(2), PIGC(1), PIGF(1), PIGG(9), PIGK(3), PIGL(2), PIGN(2), PIGO(6), PIGQ(5), PIGS(1), PIGT(1), PIGU(2), PIGV(4), PIGX(1), PIGZ(1), ST3GAL1(5), ST3GAL5(1), ST3GAL6(2), ST6GALNAC3(3), ST6GALNAC5(4), ST6GALNAC6(1), ST8SIA5(3)	7435104	125	55	125	74	82	13	6	13	11	0	0.385	1.000	1.000
249	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(6), ALOX12(2), ALOX15(4), ALOX5(6), CYP4F2(6), CYP4F3(11), EPX(4), GGT1(3), LPO(8), LTA4H(2), MPO(5), PLA2G2A(1), PLA2G2E(2), PLA2G3(12), PLA2G4A(7), PLA2G6(7), PRDX1(1), PRDX2(2), PRDX6(1), PTGDS(1), PTGIS(8), PTGS1(12), PTGS2(6), TBXAS1(7), TPO(28)	4284039	152	55	149	97	115	12	3	14	8	0	0.343	1.000	1.000
250	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(3), AKT1(1), APC(11), DAG1(3), DLG4(3), EPHB2(15), GNAQ(1), ITPR1(16), ITPR2(10), ITPR3(4), KCNJ3(11), KCNJ5(6), KCNJ9(2), MAPK1(2), PITX2(1), RAC1(7), RHO(2), RYR1(52)	6976722	150	55	146	106	112	14	6	8	10	0	0.686	1.000	1.000
251	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(2), UGP2(1), UGT1A1(1), UGT1A10(10), UGT1A3(6), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(7), UGT1A8(2), UGT1A9(5), UGT2A1(8), UGT2A3(14), UGT2B10(17), UGT2B11(10), UGT2B15(16), UGT2B28(14), UGT2B4(18), UGT2B7(8), XYLB(2)	4165367	154	54	148	63	110	12	7	9	16	0	0.0229	1.000	1.000
252	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(3), AANAT(1), ABP1(10), ACAT2(1), ACMSD(5), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2), AOC2(5), AOC3(5), AOX1(13), ASMT(3), CARM1(2), CAT(3), CYP1A1(8), CYP1A2(8), CYP1B1(1), DDC(5), EHHADH(5), GCDH(3), HAAO(1), HADHA(7), HEMK1(1), HSD17B10(1), HSD17B4(3), INMT(4), KMO(4), KYNU(5), LCMT1(3), LNX1(11), MAOA(2), MAOB(7), METTL2B(5), NFX1(4), OGDH(7), OGDHL(22), PRMT2(1), PRMT3(3), PRMT5(3), PRMT6(1), PRMT7(1), PRMT8(7), TDO2(2), TPH1(1), TPH2(6), WARS(3), WARS2(1)	9289271	211	54	206	109	158	16	9	17	11	0	0.115	1.000	1.000
253	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(5), AGPAT2(3), AGPAT3(3), AGPAT4(4), CDS1(5), CDS2(2), CHAT(10), CHKA(2), CHKB(1), CHPT1(1), DGKA(1), DGKB(14), DGKD(3), DGKE(5), DGKG(8), DGKH(6), DGKI(12), DGKQ(2), DGKZ(6), GNPAT(1), GPAM(5), GPD1(6), GPD1L(1), GPD2(1), LYPLA1(1), LYPLA2(1), MYST3(9), MYST4(11), NAT6(2), PCYT1A(2), PCYT1B(2), PEMT(1), PISD(2), PLA2G12B(3), PLA2G2A(1), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(12), PLA2G4A(7), PLA2G6(7), PLD1(5), PLD2(2), PNPLA3(1), PPAP2B(4), PPAP2C(5), SH3GLB1(1)	10027795	195	54	188	106	139	16	5	18	17	0	0.441	1.000	1.000
254	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(3), CRK(2), DOCK1(11), FOS(1), GAB1(3), GRB2(2), HGF(8), ITGA1(14), ITGB1(3), JUN(1), MAP2K1(3), MAP2K2(2), MAP4K1(3), MAPK1(2), MAPK3(1), MET(7), PAK1(2), PIK3CA(2), PIK3R1(2), PTEN(11), PTK2(2), PTK2B(7), PTPN11(3), PXN(3), RAF1(2), RAP1A(1), RASA1(1), SOS1(4), STAT3(6)	6693195	112	54	109	55	69	6	6	17	14	0	0.707	1.000	1.000
255	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(3), C1QB(1), C1R(8), C1S(11), C2(8), C3(21), C5(5), C6(36), C7(17), C8A(23), C8B(25), C9(11), MASP1(5)	3156701	174	53	161	76	144	8	1	10	10	1	0.0235	1.000	1.000
256	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(33), GABBR1(4), GPRC5A(2), GPRC5B(1), GPRC5C(6), GPRC5D(2), GRM1(7), GRM2(1), GRM3(30), GRM4(13), GRM5(5), GRM7(18), GRM8(26)	3205913	148	53	142	109	113	11	5	10	9	0	0.414	1.000	1.000
257	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(21), C5(5), C6(36), C7(17), ICAM1(2), IL1A(2), IL8(1), ITGA4(18), ITGAL(15), ITGB1(3), ITGB2(8), SELP(13), SELPLG(3), TNF(1), VCAM1(13)	3772581	158	53	148	76	125	3	4	10	15	1	0.0909	1.000	1.000
258	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(1), AKT1(1), AKT2(6), AKT3(2), BTK(6), CDKN2A(16), DAPP1(2), GRB2(2), GSK3B(1), IARS(1), IGFBP1(1), INPP5D(19), PDK1(1), PIK3CA(2), PPP1R13B(3), PTEN(11), RPS6KA1(2), RPS6KA2(4), RPS6KB1(1), SFN(1), SOS1(4), SOS2(3), TEC(6), YWHAG(1), YWHAQ(1)	5536854	98	53	92	35	52	8	8	9	21	0	0.125	1.000	1.000
259	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(4), AKR1D1(9), ARSD(1), ARSE(2), CYP11B1(7), CYP11B2(8), HSD11B1(6), HSD17B2(6), HSD17B3(5), HSD3B1(1), HSD3B2(9), SRD5A1(2), SRD5A2(4), STS(1), SULT1E1(7), SULT2A1(4), UGT1A1(1), UGT1A10(10), UGT1A3(6), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(7), UGT1A8(2), UGT1A9(5), UGT2B15(16), UGT2B4(18)	4174591	152	52	145	77	100	13	8	9	22	0	0.0903	1.000	1.000
260	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(2), ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), AKR1C4(4), AKR1D1(9), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH9A1(2), BAAT(6), CEL(4), CYP27A1(2), CYP7A1(4), HADHB(2), SOAT2(4), SRD5A1(2), SRD5A2(4)	3589247	130	52	122	51	86	13	8	10	13	0	0.00606	1.000	1.000
261	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(3), APOA1(1), CD36(3), CPT1B(4), CREBBP(12), EHHADH(5), EP300(7), FABP1(3), HSD17B4(3), JUN(1), LPL(2), MAPK1(2), MAPK3(1), ME1(11), MYC(2), NCOA1(5), NCOR1(12), NCOR2(14), NFKBIA(1), NR0B2(5), NR1H3(2), NR2F1(7), NRIP1(5), PDGFA(1), PIK3CA(2), PIK3R1(2), PPARA(3), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKCA(5), PTGS2(6), RB1(3), RELA(1), RXRA(1), SP1(3), STAT5A(2), STAT5B(2), TNF(1)	9749372	156	52	153	76	110	12	11	10	11	2	0.292	1.000	1.000
262	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(1), AKT2(6), AKT3(2), BCR(6), BLNK(10), BTK(6), CD19(3), CSK(1), DAG1(3), EPHB2(15), GRB2(2), ITPKB(4), LYN(1), MAP2K1(3), MAP2K2(2), MAPK1(2), NFAT5(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(1), NFKBIL1(3), PI3(5), PIK3CA(2), PIK3CD(2), PIK3R1(2), PLCG2(9), PPP1R13B(3), RAF1(2), SERPINA4(6), SOS1(4), SOS2(3), SYK(9), VAV1(12)	8116306	138	52	136	80	90	14	10	13	11	0	0.626	1.000	1.000
263	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(2), ACAD8(1), ACAD9(1), ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), AKR1B10(5), AKR1C4(4), AKR1D1(9), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2), BAAT(6), CEL(4), CYP27A1(2), CYP7A1(4), HADHB(2), RDH12(1), RDH13(3), SLC27A5(3), SOAT1(1), SOAT2(4), SRD5A1(2), SRD5A2(4)	4886218	136	51	128	65	94	11	10	8	13	0	0.0489	1.000	1.000
264	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(1), C1GALT1(4), C1GALT1C1(1), GALNT1(2), GALNT10(2), GALNT11(1), GALNT12(5), GALNT13(9), GALNT14(14), GALNT2(4), GALNT3(2), GALNT4(2), GALNT5(7), GALNT6(11), GALNT7(4), GALNT8(14), GALNTL1(2), GALNTL2(10), GALNTL4(1), GALNTL5(13), GCNT1(4), GCNT3(3), OGT(3), ST3GAL1(5), ST6GALNAC1(3), WBSCR17(20)	4963483	147	51	143	64	109	9	2	11	16	0	0.0507	1.000	1.000
265	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(1), DLG4(3), GRIN1(6), GRIN2A(48), GRIN2B(28), GRIN2C(6), GRIN2D(3), NOS1(32), PPP3CA(4), PPP3CB(1), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKCA(5), SYT1(11)	3904994	161	51	158	104	127	13	2	10	9	0	0.393	1.000	1.000
266	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(3), C1QB(1), C1R(8), C1S(11), C2(8), C3(21), C5(5), C6(36), C7(17), C8A(23), C9(11), MASP1(5), MASP2(7), MBL2(7)	3236178	163	50	152	72	133	7	0	10	12	1	0.0358	1.000	1.000
267	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(3), APAF1(3), ARHGDIB(1), BAG4(1), BCL2(2), BIRC2(4), BIRC3(5), CASP2(1), CASP7(3), CASP8(1), CASP9(2), CFLAR(3), CHUK(1), CRADD(1), CYCS(1), DAXX(4), DFFA(1), DFFB(2), GSN(3), LMNA(3), LMNB2(4), MAP2K7(2), MAP3K14(1), MAP3K5(9), MDM2(2), NFKB1(1), NFKBIA(1), NUMA1(5), PAK2(2), PRKCD(2), PRKDC(11), PSEN2(2), PTK2(2), RASA1(1), RB1(3), RELA(1), RIPK1(1), SPTAN1(2), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF1(4), TRAF2(1)	10641746	106	50	106	51	56	13	10	15	10	2	0.319	1.000	1.000
268	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(20), ATP4A(8), ATP5A1(1), ATP5B(1), ATP5C1(1), ATP5F1(6), ATP5H(1), ATP5O(3), ATP6V0A1(3), ATP6V0A4(11), ATP6V0D2(6), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(6), ATP6V1E2(1), ATP6V1F(1), ATP6V1G3(5), ATP6V1H(4), COX10(3), COX15(1), COX4I2(1), COX5B(1), COX7B(1), COX7B2(1), COX8A(1), CYC1(3), LHPP(1), NDUFA12(1), NDUFA13(5), NDUFA9(2), NDUFB6(2), NDUFC2(1), NDUFS2(1), NDUFS3(1), NDUFS4(1), NDUFS5(1), NDUFS6(1), NDUFS7(2), NDUFS8(1), PPA1(1), PPA2(2), SDHA(1), SDHC(2), TCIRG1(2), UQCRC1(1), UQCRFS1(1)	8619605	124	50	120	70	76	15	8	14	11	0	0.541	1.000	1.000
269	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(3), AASDHPPT(1), AASS(1), ACAT2(1), AKR1B10(5), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2), BBOX1(3), DOT1L(4), EHHADH(5), EHMT1(5), EHMT2(3), GCDH(3), HADHA(7), HSD17B10(1), HSD17B4(3), NSD1(8), OGDH(7), OGDHL(22), PIPOX(1), PLOD1(1), PLOD2(3), PLOD3(1), RDH12(1), RDH13(3), SETD1A(15), SETD7(1), SETDB1(1), SHMT2(2), TMLHE(1)	8877517	126	50	125	60	86	12	6	14	8	0	0.158	1.000	1.000
270	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(5), BCR(6), BLNK(10), FOS(1), GRB2(2), JUN(1), LYN(1), MAP2K1(3), MAPK1(2), MAPK3(1), MAPK8IP3(4), PAPPA(35), RAC1(7), RPS6KA1(2), SOS1(4), SYK(9), VAV1(12), VAV2(3), VAV3(5)	4877896	113	50	108	60	85	6	3	11	8	0	0.403	1.000	1.000
271	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT2(2), G6PC(4), GAA(3), GALK2(1), GALT(2), GANAB(4), GCK(8), GLB1(5), HK1(1), HK2(4), HK3(10), LALBA(4), LCT(24), MGAM(71), PGM1(2), PGM3(1)	4987816	148	49	142	76	111	16	2	13	6	0	0.0640	1.000	1.000
272	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(5), AGPAT2(3), AGPAT3(3), AGPAT4(4), AGPS(1), CDS1(5), CDS2(2), CHAT(10), CHKA(2), CHKB(1), CLC(2), CPT1B(4), DGKA(1), DGKB(14), DGKD(3), DGKE(5), DGKG(8), DGKH(6), DGKQ(2), DGKZ(6), GNPAT(1), GPD1(6), GPD2(1), LGALS13(1), LYPLA1(1), LYPLA2(1), PAFAH1B1(2), PAFAH2(2), PCYT1A(2), PCYT1B(2), PEMT(1), PISD(2), PLA2G2A(1), PLA2G2E(2), PLA2G3(12), PLA2G4A(7), PLA2G6(7), PLCB2(4), PLCG1(4), PLCG2(9), PPAP2B(4), PPAP2C(5)	7663026	164	49	160	89	125	10	3	14	12	0	0.159	1.000	1.000
273	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), AKR1B10(5), B4GALT2(2), G6PC(4), G6PC2(2), GAA(3), GALK2(1), GALT(2), GANC(1), GCK(8), GLB1(5), HK1(1), HK2(4), HK3(10), LALBA(4), LCT(24), MGAM(71), PFKL(2), PGM1(2), PGM3(1), RDH12(1), RDH13(3), UGP2(1)	5911795	159	49	153	85	121	15	2	13	8	0	0.0794	1.000	1.000
274	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(3), AARS2(2), ABAT(5), ACY3(1), ADSL(6), ADSSL1(4), AGXT(8), AGXT2(10), ASL(2), ASNS(4), ASPA(2), ASRGL1(1), ASS1(2), CAD(11), CRAT(4), DARS(2), DARS2(1), DDO(2), DLAT(2), GAD1(6), GAD2(3), GOT1(4), GOT2(2), GPT(3), NARS(1), NARS2(4), PC(5), PDHA1(1), PDHA2(7), PDHB(1)	5837064	109	49	107	58	75	10	7	12	5	0	0.288	1.000	1.000
275	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(10), AGXT(8), AGXT2(10), AKR1B10(5), ALAS2(2), AMT(1), AOC2(5), AOC3(5), BHMT(6), CBS(3), CHDH(5), CHKA(2), CHKB(1), DAO(6), DMGDH(8), GAMT(2), GARS(4), GATM(1), GCAT(3), GLDC(2), GNMT(1), MAOA(2), MAOB(7), PEMT(1), PHGDH(9), PIPOX(1), PISD(2), PSAT1(1), RDH12(1), RDH13(3), SARDH(8), SARS(4), SARS2(2), SHMT2(2), TARS(1), TARS2(5)	6563936	139	49	133	75	103	7	6	10	13	0	0.161	1.000	1.000
276	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(12), ACACB(12), ACAT2(1), ACOT12(7), ACSS2(3), AKR1B1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2), DLAT(2), GLO1(1), HAGH(1), LDHA(2), LDHAL6B(5), LDHC(1), LDHD(1), MDH1(1), MDH2(1), ME1(11), ME2(1), ME3(6), PC(5), PCK1(15), PCK2(2), PDHA1(1), PDHA2(7), PDHB(1), PKLR(6), PKM2(4)	7207341	125	49	122	61	90	9	4	8	14	0	0.0840	1.000	1.000
277	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), ASCC3(4), ATP13A2(6), DDX18(1), DDX23(4), DDX4(7), DDX41(3), DDX47(1), DDX50(2), DDX51(3), DDX52(3), DDX55(2), DDX56(2), DHX58(3), ENTPD7(1), EP400(13), ERCC2(1), ERCC3(2), FPGS(3), GGH(1), IFIH1(4), MOV10L1(16), NUDT5(1), NUDT8(1), QDPR(1), RAD54B(4), RUVBL2(1), SETX(12), SKIV2L2(3), SMARCA2(8), SMARCA5(3), SPR(1)	9582668	134	49	130	69	85	10	3	19	17	0	0.455	1.000	1.000
278	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(3), AARS2(2), CARS(5), DARS(2), DARS2(1), EPRS(4), FARSA(4), FARSB(2), GARS(4), HARS(2), HARS2(2), IARS(1), IARS2(9), KARS(2), LARS(8), LARS2(3), MARS(4), MARS2(3), MTFMT(1), NARS(1), NARS2(4), QARS(6), RARS(4), RARS2(1), SARS(4), SARS2(2), TARS(1), TARS2(5), VARS(10), VARS2(4), WARS(3), WARS2(1), YARS2(1)	8432700	109	49	104	50	68	11	6	12	12	0	0.232	1.000	1.000
279	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), AKT2(6), AKT3(2), ARHGEF11(9), BCL2(2), DLG4(3), GNA13(1), LPA(24), MAP2K4(3), MAP3K5(9), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(1), NFKBIL1(3), PDK1(1), PHKA2(5), PI3(5), PIK3CB(10), PLD1(5), PLD2(2), PLD3(1), PTK2(2), ROCK1(2), ROCK2(4), SERPINA4(6), SRF(1), TBXA2R(3)	7523195	116	49	115	66	68	11	5	22	10	0	0.807	1.000	1.000
280	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(1), AKT2(6), AKT3(2), ANKRD6(2), APC(11), AXIN1(6), AXIN2(2), CER1(6), CSNK1A1(1), CTNNB1(5), DACT1(4), DKK1(1), DKK2(7), DKK3(3), DKK4(1), FSTL1(2), GSK3B(1), LRP1(14), MVP(3), NKD1(5), NKD2(4), PTPRA(2), SENP2(8), TSHB(2), WIF1(4)	6129504	103	49	103	58	62	14	2	12	13	0	0.712	1.000	1.000
281	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(3), C1QB(1), C1R(8), C1S(11), C2(8), C3(21), C5(5), C6(36), C7(17), C8A(23), C9(11)	2650657	144	48	133	64	117	6	0	10	10	1	0.0607	1.000	1.000
282	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(5), ALDOC(1), DLAT(2), ENO1(2), ENO3(1), FBP1(1), G6PC(4), GCK(8), GOT1(4), GOT2(2), GPI(2), HK1(1), HK2(4), HK3(10), LDHA(2), LDHAL6B(5), LDHC(1), MDH1(1), MDH2(1), PC(5), PCK1(15), PDHA1(1), PDHA2(7), PDHB(1), PDHX(2), PFKL(2), PGK1(1), PGK2(15), PKLR(6), PKM2(4)	6540738	117	48	112	61	93	5	5	4	10	0	0.0316	1.000	1.000
283	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), ADRBK2(3), ARRB2(3), CALM2(1), CALML3(3), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CLCA1(4), CLCA2(5), CLCA4(17), CNGA3(13), CNGA4(7), CNGB1(10), GNAL(2), GUCA1A(2), GUCA1B(1), GUCA1C(3), PDC(2), PDE1C(23), PRKACA(2), PRKACB(2), PRKACG(5), PRKG1(5), PRKG2(8), PRKX(1)	4621304	135	48	129	79	95	12	6	14	8	0	0.437	1.000	1.000
284	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(3), ACTG2(1), ADCY3(2), ADCY9(9), AK1(1), ARF4(1), ARF5(1), ARL4D(2), ATP6V0A1(3), ATP6V0A4(11), ATP6V0D2(6), ATP6V1A(2), ATP6V1C2(6), ATP6V1E2(1), ATP6V1F(1), ATP6V1G3(5), ATP6V1H(4), ERO1L(3), GNAS(12), PDIA4(1), PLCG1(4), PLCG2(9), PRKCA(5), SEC61A1(2), SEC61A2(3)	5709266	98	48	97	75	67	5	3	12	11	0	0.935	1.000	1.000
285	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(2), CHUK(1), DAXX(4), EGF(14), EGFR(13), ETS1(3), ETS2(7), FOS(1), HOXA7(2), IKBKB(2), JUN(1), MAP2K1(3), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP2K7(2), MAP3K14(1), MAP3K5(9), MAPK1(2), MAPK13(2), MAPK14(4), MAPK3(1), NFKB1(1), NFKBIA(1), PPP2CA(1), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCH(2), PRKCQ(12), RAF1(2), RELA(1), RIPK1(1), SP1(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(1)	7516002	131	48	130	86	91	10	5	12	13	0	0.891	1.000	1.000
286	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(3), ANXA2(1), ANXA3(3), ANXA4(1), ANXA5(1), ANXA6(3), CYP11A1(8), EDN1(6), EDNRA(3), EDNRB(3), HSD11B1(6), PLA2G4A(7), PRL(1), PTGDR(7), PTGDS(1), PTGER2(4), PTGFR(12), PTGIR(3), PTGIS(8), PTGS1(12), PTGS2(6), TBXAS1(7)	3136054	106	48	101	50	81	9	3	7	6	0	0.0282	1.000	1.000
287	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(12), ACAT2(1), AKR1B1(2), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH9A1(2), DLAT(2), GLO1(1), HAGH(1), LDHA(2), LDHC(1), LDHD(1), MDH1(1), MDH2(1), ME1(11), ME2(1), ME3(6), PC(5), PCK1(15), PDHA1(1), PDHA2(7), PDHB(1), PKLR(6), PKM2(4)	5695567	105	48	104	49	75	8	3	8	11	0	0.110	1.000	1.000
288	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(2), ACADL(2), ACADM(3), ACADSB(3), ACAT2(1), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH6A1(2), ALDH9A1(2), AOX1(13), BCAT1(6), BCKDHA(1), EHHADH(5), HADHA(7), HADHB(2), HIBADH(6), HMGCL(2), IVD(2), MCCC1(4), MCEE(1), MUT(4), OXCT1(3), PCCA(2), PCCB(1)	5559234	95	48	92	39	61	9	3	12	10	0	0.149	1.000	1.000
289	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(8), ATR(13), BRCA1(6), BRCA2(10), CHEK1(1), FANCA(2), FANCC(2), FANCD2(10), FANCE(1), FANCF(1), FANCG(3), HUS1(1), MRE11A(2), RAD1(2), RAD17(3), RAD50(3), RAD9A(4), TP53(20)	6788441	92	47	88	32	60	1	5	11	15	0	0.189	1.000	1.000
290	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(3), AGTR2(2), CALM2(1), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CDK5(3), F2(6), FYN(4), GNA11(2), GRB2(2), JAK2(6), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK14(4), MAPK3(1), MAPT(4), MYLK(17), PLCG1(4), PRKCA(5), PTK2B(7), RAF1(2), SOS1(4), STAT1(2), STAT3(6), STAT5A(2), SYT1(11)	6363040	116	47	115	77	81	9	6	10	10	0	0.844	1.000	1.000
291	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(16), AKT1(1), ITGAV(4), ITGB3(7), MAPK1(2), MAPK3(1), PDGFA(1), PDGFRA(13), PIK3CA(2), PIK3R1(2), PLCB1(29), PRKCA(5), PTK2(2), RAC1(7), SMPD1(1), SPHK1(1)	4232882	94	47	90	39	71	4	4	10	5	0	0.0642	1.000	1.000
292	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(6), CALM2(1), FCER1A(6), FCER1G(1), FOS(1), GRB2(2), JUN(1), LYN(1), MAP2K1(3), MAP2K4(3), MAP2K7(2), MAPK1(2), MAPK3(1), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), PAK2(2), PIK3CA(2), PIK3R1(2), PLA2G4A(7), PLCG1(4), PPP3CA(4), PPP3CB(1), RAF1(2), SOS1(4), SYK(9), SYT1(11), VAV1(12)	6582012	111	47	109	57	83	6	8	8	6	0	0.555	1.000	1.000
293	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(5), ACAA1(2), ACADM(3), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH6A1(2), ALDH7A1(2), ALDH9A1(2), AOX1(13), AUH(3), BCAT1(6), BCAT2(1), BCKDHA(1), DBT(1), EHHADH(5), HADHA(7), HADHB(2), HIBADH(6), HIBCH(1), HMGCL(2), HMGCS1(1), HMGCS2(11), HSD17B10(1), HSD17B4(3), IVD(2), MCCC1(4), MCEE(1), MUT(4), OXCT1(3), OXCT2(2), PCCA(2), PCCB(1)	6638559	110	47	106	43	70	11	5	15	9	0	0.0871	1.000	1.000
294	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(5), AADAC(9), ABAT(5), ACAT2(1), ACSM1(10), AKR1B10(5), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH5A1(7), ALDH7A1(2), ALDH9A1(2), BDH1(2), DDHD1(3), EHHADH(5), GAD1(6), GAD2(3), HADHA(7), HMGCL(2), HMGCS1(1), HMGCS2(11), HSD17B10(1), HSD17B4(3), ILVBL(2), L2HGDH(1), OXCT1(3), OXCT2(2), PDHA1(1), PDHA2(7), PDHB(1), PLA1A(4), PPME1(1), PRDX6(1), RDH12(1), RDH13(3)	6251509	127	47	125	62	89	10	6	10	12	0	0.126	1.000	1.000
295	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(6), F2R(3), ITGA1(14), ITGB1(3), MAP2K1(3), MAPK1(2), MAPK3(1), PLA2G4A(7), PLCB1(29), PRKCA(5), PTGS1(12), PTK2(2), RAF1(2), SYK(9), TBXAS1(7)	3738088	105	47	101	50	82	6	3	9	5	0	0.190	1.000	1.000
296	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(3), BAX(1), BCL2(2), BIRC2(4), BIRC3(5), CASP2(1), CASP7(3), CASP8(1), CASP9(2), CYCS(1), FAS(3), FASLG(10), GZMB(1), JUN(1), MAP2K4(3), MAP3K14(1), MAPK10(5), MCL1(2), MDM2(2), MYC(2), NFKB1(1), NFKBIA(1), PARP1(7), PRF1(5), RELA(1), RIPK1(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TNFSF10(5), TP53(20), TRAF1(4), TRAF2(1)	5724972	103	46	101	41	63	9	8	9	14	0	0.0667	1.000	1.000
297	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(3), AGTR1(6), ATF2(5), CALM2(1), EGFR(13), GNAQ(1), GRB2(2), JUN(1), MAP2K1(3), MAP2K2(2), MAP2K4(3), MAPK1(2), MAPK3(1), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), PAK1(2), PRKCA(5), PTK2(2), PTK2B(7), RAC1(7), RAF1(2), SOS1(4), SYT1(11)	5123981	91	46	87	52	67	6	4	8	6	0	0.703	1.000	1.000
298	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(8), ATR(13), BRCA1(6), CDC25A(5), CDC25B(1), CDC25C(3), CDC34(3), CDKN1A(1), CHEK1(1), EP300(7), MDM2(2), MYT1(12), PRKDC(11), RPS6KA1(2), TP53(20), YWHAQ(1)	6472440	96	46	93	40	62	6	6	11	11	0	0.368	1.000	1.000
299	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(10), ACY3(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH3B1(1), ALDH3B2(4), ALDH7A1(2), ALDH9A1(2), AMDHD1(2), AOC2(5), AOC3(5), ASPA(2), CARM1(2), CNDP1(7), DDC(5), FTCD(1), HAL(8), HARS(2), HARS2(2), HDC(8), HEMK1(1), LCMT1(3), MAOA(2), MAOB(7), METTL2B(5), PRMT2(1), PRMT3(3), PRMT5(3), PRMT6(1), PRMT7(1), PRMT8(7), PRPS1(1), PRPS2(1), UROC1(8)	6068989	123	46	122	84	90	13	7	5	8	0	0.693	1.000	1.000
300	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(10), ALDH1A3(2), ALDH3A1(3), ALDH3B1(1), ALDH3B2(4), AOC2(5), AOC3(5), DDC(5), EPX(4), GOT1(4), GOT2(2), HPD(2), LPO(8), MAOA(2), MAOB(7), MPO(5), MYST3(9), MYST4(11), NAT6(2), PNPLA3(1), PRDX6(1), SH3GLB1(1), TAT(10), TPO(28)	5270878	132	46	129	92	103	11	7	6	5	0	0.840	1.000	1.000
301	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(1), ARSE(2), B4GALT6(1), DEGS1(1), DEGS2(2), ENPP7(2), GAL3ST1(7), GALC(1), GBA(2), GLB1(5), LCT(24), NEU1(4), NEU2(10), NEU3(2), NEU4(5), PPAP2B(4), PPAP2C(5), SGMS1(12), SGPP2(3), SMPD1(1), SMPD3(6), SMPD4(2), SPHK1(1), SPHK2(5), SPTLC2(4), UGT8(3)	5433043	115	46	112	86	93	7	1	10	4	0	0.928	1.000	1.000
302	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(3), CAPN1(1), CAPN2(2), CXCR3(2), EGF(14), EGFR(13), ITGA1(14), ITGB1(3), MAPK1(2), MAPK3(1), MYL2(4), MYLK(17), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PTK2(2), PXN(3), TLN1(10)	4982190	104	46	101	56	80	5	4	10	5	0	0.249	1.000	1.000
303	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM2(1), CD3D(4), CD3E(2), FOS(1), FYN(4), GRB2(2), JUN(1), LCK(4), MAP2K1(3), MAP2K4(3), MAPK3(1), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), NFKB1(1), NFKBIA(1), PIK3CA(2), PIK3R1(2), PLCG1(4), PPP3CA(4), PPP3CB(1), PRKCA(5), PTPN7(1), RAC1(7), RAF1(2), RASA1(1), RELA(1), SOS1(4), SYT1(11), VAV1(12), ZAP70(4)	7313638	110	46	106	60	82	9	4	9	6	0	0.697	1.000	1.000
304	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(1), APC(11), ATF2(5), AXIN1(6), BMP10(7), BMP2(3), BMP4(1), BMP5(9), BMP7(2), BMPR1A(1), BMPR2(3), CHRD(8), CTNNB1(5), FZD1(1), GATA4(1), GSK3B(1), MEF2C(2), MYL2(4), NPPA(1), NPPB(4), RFC1(2), TGFB2(1), TGFB3(1), TGFBR2(5), TGFBR3(4), WNT1(1)	5544575	90	45	86	48	65	7	4	4	10	0	0.676	1.000	1.000
305	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(1), EIF4A1(3), EIF4A2(2), EIF4G1(6), EIF4G2(2), EIF4G3(7), GHR(14), IRS1(2), MAPK1(2), MAPK14(4), MAPK3(1), MKNK1(5), PABPC1(3), PDK2(4), PDPK1(1), PIK3CA(2), PIK3R1(2), PRKCA(5), PTEN(11), RPS6KB1(1)	4352538	78	45	78	26	41	8	5	9	15	0	0.141	1.000	1.000
306	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ACAD9(1), ADH1A(9), ADH1B(13), ADH1C(19), ADH4(6), ADH6(6), ADH7(8), ADHFE1(3), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(2), MYST3(9), MYST4(11), NAT6(2), PNPLA3(1), SH3GLB1(1)	3861256	100	45	93	44	73	9	5	9	4	0	0.235	1.000	1.000
307	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(5), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2), CYP2C19(25), CYP2C9(24), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(2), EHHADH(5), HADHA(7), MYST3(9), MYST4(11), NAT6(2), PNPLA3(1), SH3GLB1(1)	4777267	114	45	109	74	83	10	4	8	9	0	0.851	1.000	1.000
308	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(3), ACTN1(2), ACTN2(14), ACTN3(5), BCAR1(3), BCR(6), CAPN1(1), CAV1(1), CSK(1), FYN(4), GRB2(2), ITGA1(14), ITGB1(3), JUN(1), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK3(1), PPP1R12B(5), PTK2(2), PXN(3), RAF1(2), RAP1A(1), ROCK1(2), SOS1(4), TLN1(10), VCL(4), ZYX(3)	7159390	104	45	102	48	68	11	4	14	6	1	0.137	1.000	1.000
309	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(4), ADRA1B(1), ADRA1D(3), ADRA2A(2), ADRA2C(2), ADRB1(3), ADRB2(1), CHRM1(4), CHRM2(7), CHRM3(10), CHRM4(4), CHRM5(1), DRD1(7), DRD2(8), DRD3(1), DRD4(1), DRD5(16), HRH1(9), HRH2(3), HTR1A(6), HTR1D(2), HTR1E(3), HTR1F(5), HTR2A(6), HTR2C(5), HTR4(4), HTR5A(10), HTR6(1), HTR7(4)	3862817	133	45	130	104	86	16	5	13	13	0	0.196	1.000	1.000
310	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), CDK5(3), CHN1(2), LIMK1(4), MYL2(4), MYLK(17), NCF2(4), PAK1(2), PDGFRA(13), PIK3CA(2), PIK3R1(2), PLD1(5), PPP1R12B(5), RAC1(7), RALBP1(1), RPS6KB1(1), TRIO(8), VAV1(12), WASF1(1)	5380380	94	45	88	55	67	4	4	11	8	0	0.765	1.000	1.000
311	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(2), AKT1(1), ANGPTL2(2), DAG1(3), DGKA(1), ETFA(1), GCA(2), ITGA9(9), ITPKB(4), ITPR1(16), ITPR2(10), ITPR3(4), MAP2K1(3), MAPK1(2), MAPK3(1), NR1I3(5), PAK1(2), PDE3A(13), PDE3B(3), PI3(5), PIK3C2G(20), PIK3CA(2), PIK3CD(2), PIK3R1(2), RIPK3(7)	7440573	122	45	120	52	92	11	6	5	8	0	0.0172	1.000	1.000
312	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(4), EIF2B1(5), EIF2B2(1), EIF2B3(3), EIF2B5(1), EIF2S1(1), FLT1(17), FLT4(16), KDR(22), NOS3(11), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(5), PTK2(2), PXN(3), VHL(1)	5245662	100	45	92	53	68	9	1	10	12	0	0.436	1.000	1.000
313	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(21), C5(5), C6(36), C7(17), C8A(23), C9(11)	1902674	113	44	104	49	94	3	0	6	9	1	0.100	1.000	1.000
314	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(3), BAX(1), BCL2(2), CASP1(3), CASP10(3), CASP2(1), CASP4(1), CASP7(3), CASP8(1), CASP9(2), CD40(1), CD40LG(1), CRADD(1), CYCS(1), DAXX(4), DFFA(1), DFFB(2), FAS(3), FASLG(10), IKBKE(5), LTA(2), MCL1(2), NFKB1(1), NFKBIA(1), NGFR(6), NR3C1(1), NTRK1(9), PTPN13(7), RIPK1(1), SFRS2IP(5), TFG(2), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF1(4), TRAF2(1), TRAF3(3), TRAF6(2)	6659026	100	44	100	55	69	8	5	7	11	0	0.535	1.000	1.000
315	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(10), AGXT(8), AGXT2(10), ALAS2(2), AMT(1), AOC2(5), AOC3(5), BHMT(6), CBS(3), CHDH(5), CHKA(2), CHKB(1), CPT1B(4), DAO(6), DMGDH(8), GAMT(2), GARS(4), GATM(1), GCAT(3), GLDC(2), MAOA(2), MAOB(7), PEMT(1), PISD(2), PLCB2(4), PLCG1(4), PLCG2(9), SARDH(8), SARS(4), SHMT2(2), TARS(1)	6458099	132	44	129	79	101	7	6	7	11	0	0.300	1.000	1.000
316	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(10), ALDH1A3(2), ALDH3A1(3), ALDH3B1(1), ALDH3B2(4), AOC2(5), AOC3(5), DDC(5), EPX(4), GOT1(4), GOT2(2), HPD(2), LPO(8), MAOA(2), MAOB(7), MPO(5), PRDX1(1), PRDX2(2), PRDX6(1), TAT(10), TPO(28)	3365725	111	44	109	74	89	8	6	4	4	0	0.367	1.000	1.000
317	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(5), ACACA(12), ACADL(2), ACADM(3), ACADSB(3), ACAT2(1), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH6A1(2), ALDH9A1(2), EHHADH(5), HADHA(7), LDHA(2), LDHC(1), MCEE(1), MLYCD(2), MUT(4), PCCA(2), PCCB(1)	5116436	76	44	75	35	48	7	4	12	5	0	0.405	1.000	1.000
318	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(1), ERCC3(2), GTF2A2(1), GTF2B(1), GTF2E2(4), GTF2F2(2), GTF2H1(3), GTF2H4(1), MNAT1(2), POLR1A(7), POLR1B(4), POLR2A(8), POLR2B(10), POLR2E(1), POLR2F(1), POLR2H(2), POLR3B(10), POLR3D(1), POLR3E(1), POLR3K(1), TAF6(2), TAF7(1), TAF9(1), TBP(4)	5412372	71	44	71	25	45	9	5	9	3	0	0.0714	1.000	1.000
319	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(4), EGF(14), EGFR(13), GRB2(2), MAP2K1(3), MAPK1(2), MAPK3(1), PTPRB(52), RAF1(2), RASA1(1), SOS1(4), SPRY1(6), SPRY2(3), SPRY3(6), SPRY4(1)	3830896	114	44	106	51	90	8	2	8	6	0	0.243	1.000	1.000
320	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(10), BTK(6), CALM2(1), CD79A(1), FOS(1), GRB2(2), JUN(1), LYN(1), MAP2K1(3), MAPK14(4), MAPK3(1), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), PLCG1(4), PPP3CA(4), PPP3CB(1), PRKCA(5), RAC1(7), RAF1(2), SOS1(4), SYK(9), SYT1(11), VAV1(12)	5866039	111	43	106	54	83	5	5	9	9	0	0.382	1.000	1.000
321	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(13), GNAS(12), GRB2(2), IGF1R(5), ITGB1(3), KLK2(1), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK3(1), MKNK1(5), MKNK2(2), MYC(2), NGFR(6), PDGFRA(13), PPP2CA(1), PTPRR(18), RAF1(2), RPS6KA1(2), RPS6KA5(3), SOS1(4), STAT3(6)	5039944	108	43	105	52	77	7	6	12	6	0	0.229	1.000	1.000
322	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(4), ASL(2), ASS1(2), CKM(1), CKMT1A(1), CKMT2(5), CPS1(12), DAO(6), EPRS(4), GAMT(2), GATM(1), GLUD1(1), GOT1(4), GOT2(2), NOS1(32), NOS3(11), OAT(1), OTC(2), P4HA1(6), P4HA2(4), P4HA3(7), PRODH(1), PYCR2(1), RARS(4), RARS2(1)	5492767	117	43	114	73	87	8	6	7	9	0	0.608	1.000	1.000
323	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT2(2), EXTL3(2), GLCE(6), HS2ST1(1), HS3ST1(6), HS3ST2(6), HS3ST3B1(2), HS3ST5(5), HS6ST1(1), HS6ST2(1), HS6ST3(9), NDST1(2), NDST3(13), NDST4(29)	3120031	85	43	84	37	62	5	3	6	9	0	0.0421	1.000	1.000
324	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(5), ACACA(12), ACACB(12), ACADM(3), ACAT2(1), ACSS2(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH6A1(2), ALDH7A1(2), ALDH9A1(2), EHHADH(5), HADHA(7), HIBCH(1), LDHA(2), LDHAL6B(5), LDHC(1), MCEE(1), MLYCD(2), MUT(4), PCCA(2), PCCB(1)	6131990	83	43	81	44	52	8	4	12	7	0	0.516	1.000	1.000
325	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(16), AR(7), ESR1(2), ESR2(4), ESRRA(1), HNF4A(10), NPM1(1), NR0B1(1), NR1D2(4), NR1H2(2), NR1H3(2), NR1I2(2), NR1I3(5), NR2C2(2), NR2E1(2), NR2F1(7), NR3C1(1), NR4A1(1), NR4A2(1), NR5A1(6), NR5A2(9), PGR(10), PPARA(3), PPARD(1), PPARG(6), RARB(3), RARG(1), ROR1(6), RORA(2), RORC(5), RXRA(1), RXRB(1), RXRG(1), THRA(1), THRB(10), VDR(2)	6394318	139	43	131	78	110	11	2	9	7	0	0.259	1.000	1.000
326	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(3), BLVRA(1), BLVRB(1), CP(8), CPOX(2), EPRS(4), FECH(1), GUSB(2), HCCS(1), HMBS(1), HMOX1(1), PPOX(2), UGT1A1(1), UGT1A10(10), UGT1A3(6), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(7), UGT1A8(2), UGT1A9(5), UGT2B15(16), UGT2B4(18), UROS(1)	4252460	104	43	100	50	71	8	5	7	13	0	0.221	1.000	1.000
327	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(4), AKT1(1), AKT2(6), AKT3(2), DAG1(3), GNAQ(1), ITPKB(4), ITPR1(16), ITPR2(10), ITPR3(4), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(1), NFKBIL1(3), PDK1(1), PHKA2(5), PIK3CB(10), PITX2(1), PLD1(5), PLD2(2), PLD3(1)	6875589	85	43	84	60	46	10	6	15	8	0	0.891	1.000	1.000
328	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), DAG1(3), ITPKB(4), ITPR1(16), ITPR2(10), ITPR3(4), NFAT5(3), PDE6A(9), PDE6B(11), PDE6C(16), PDE6D(2), PDE6G(2), SLC6A13(13), TF(4)	5468271	108	43	105	56	75	8	3	9	13	0	0.111	1.000	1.000
329	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(3), CHUK(1), FOS(1), IKBKB(2), JUN(1), LY96(3), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP3K14(1), MAPK14(4), MYD88(1), NFKB1(1), NFKBIA(1), PPARA(3), RELA(1), TLR10(8), TLR2(8), TLR3(6), TLR4(21), TLR6(3), TLR7(3), TLR9(7), TOLLIP(1), TRAF6(2)	5562889	91	43	90	56	63	9	3	12	4	0	0.738	1.000	1.000
330	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(6), CARM1(2), CREBBP(12), EP300(7), ERCC3(2), ESR1(2), GRIP1(3), GTF2F1(2), HDAC1(1), HDAC3(3), HDAC4(8), HDAC5(3), HDAC6(1), MEF2C(2), NCOR2(14), NR0B1(1), NRIP1(5), PELP1(8), POLR2A(8), TBP(4)	6957591	94	42	94	42	69	5	6	8	6	0	0.223	1.000	1.000
331	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(7), GNAQ(1), GNAS(12), LIMK1(4), MAP2K1(3), MAPK1(2), MAPK3(1), MYL2(4), NOX1(6), PIK3C2G(20), PLCB1(29), PPP1R12B(5), PRKCA(5), PTK2(2), RAF1(2), ROCK2(4)	3846026	107	42	102	42	80	3	2	15	7	0	0.0836	1.000	1.000
332	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(12), CALCR(11), CALCRL(8), CD97(5), CRHR1(1), CRHR2(1), ELTD1(13), EMR1(15), EMR2(1), GHRHR(4), GIPR(2), GLP1R(5), GLP2R(5), LPHN1(4), LPHN2(22), LPHN3(8), SCTR(3), VIPR1(3), VIPR2(3)	4031555	126	42	119	90	95	9	4	6	12	0	0.600	1.000	1.000
333	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(1), APC(11), AXIN1(6), CD14(3), CTNNB1(5), FZD1(1), GJA1(4), GSK3B(1), LBP(5), LEF1(1), LY96(3), MYD88(1), NFKB1(1), PDPK1(1), PIK3CA(2), PIK3R1(2), PPP2CA(1), RELA(1), TLR4(21), TOLLIP(1), WNT1(1)	4653570	73	42	71	49	48	6	4	7	8	0	0.953	1.000	1.000
334	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(10), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH3B1(1), ALDH3B2(4), ALDH9A1(2), AOC2(5), AOC3(5), ASPA(2), CNDP1(7), DDC(5), HAL(8), HARS(2), HDC(8), MAOA(2), MAOB(7), PRPS1(1), PRPS2(1)	3730129	91	42	91	60	65	10	6	5	5	0	0.590	1.000	1.000
335	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(7), ABCC2(6), ABCG2(6), BCHE(5), CES1(11), CES2(3), CYP3A4(12), CYP3A5(4), UGT1A1(1), UGT1A10(10), UGT1A3(6), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(7), UGT1A8(2), UGT1A9(5)	3526098	96	42	92	40	65	7	6	8	10	0	0.0137	1.000	1.000
336	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(4), HLA-A(1), IL18(2), ITGB1(3), KLRC1(2), KLRC2(1), KLRC3(5), KLRC4(3), KLRD1(4), MAP2K1(3), MAPK3(1), PAK1(2), PIK3CA(2), PIK3R1(2), PTK2B(7), PTPN6(1), RAC1(7), SYK(9), VAV1(12)	2849211	71	42	65	32	54	4	2	5	6	0	0.255	1.000	1.000
337	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(5), DAXX(4), DDIT3(1), GRB2(2), HMGN1(1), HSPB1(1), HSPB2(1), MAP2K4(3), MAP2K6(2), MAP3K5(9), MAP3K9(13), MAPK14(4), MAPKAPK2(2), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), MKNK1(5), MYC(2), PLA2G4A(7), RAC1(7), RIPK1(1), RPS6KA5(3), STAT1(2), TGFB2(1), TGFB3(1), TRAF2(1)	5571357	86	42	83	36	62	8	2	8	6	0	0.209	1.000	1.000
338	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(2), ESR2(4), PDE1A(21), PDE1B(6), PLCB1(29), PLCB2(4), PRL(1), TRH(3), VIP(3)	1687024	73	42	68	38	62	1	1	5	4	0	0.231	1.000	1.000
339	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(6), DLG4(3), EPHB2(15), F2(6), F2RL1(7), F2RL2(3), JUN(1), MAP2K5(2), MAPK1(2), MAPK7(2), PLD1(5), PLD2(2), PLD3(1), PTK2(2), RAF1(2), RASAL1(10), TEC(6), VAV1(12)	4203170	87	42	84	58	60	6	3	14	4	0	0.831	1.000	1.000
340	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(1), AKT2(6), AKT3(2), CISH(1), GRB2(2), IARS(1), IL13RA1(2), IL2RG(2), IL4(1), IL4R(5), INPP5D(19), JAK1(4), JAK2(6), JAK3(5), NR0B2(5), PI3(5), PIK3CA(2), PPP1R13B(3), RPS6KB1(1), SERPINA4(6), SOS1(4), SOS2(3), STAT6(2), TYK2(3)	5649932	91	42	91	48	63	8	5	8	7	0	0.568	1.000	1.000
341	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), ATF1(2), CREB5(7), DUSP10(6), EEF2K(2), HSPB1(1), IL1R1(6), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP3K10(5), MAP3K4(9), MAP3K5(9), MAPK1(2), MAPK11(1), MAPK13(2), MAPK14(4), MAPKAPK2(2), MKNK1(5), MKNK2(2), NFKB1(1), NR2C2(2), SRF(1), TRAF6(2)	5101886	81	42	81	39	56	7	3	8	7	0	0.314	1.000	1.000
342	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(1), BCL2(2), EGFR(13), IGF1R(5), MYC(2), POLR2A(8), PPP2CA(1), PRKCA(5), RB1(3), TEP1(17), TERT(4), TNKS(4), TP53(20)	4324762	85	42	83	46	48	8	5	10	12	2	0.585	1.000	1.000
343	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(29), CR2(16), FCGR2B(1), HLA-DRA(5), ICAM1(2), ITGAL(15), ITGB2(8), PTPRC(18)	2301912	94	41	87	44	75	6	0	5	8	0	0.267	1.000	1.000
344	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(5), ABAT(5), ACAT2(1), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH5A1(7), ALDH9A1(2), EHHADH(5), GAD1(6), GAD2(3), HADHA(7), HMGCL(2), L2HGDH(1), OXCT1(3), PDHA1(1), PDHA2(7), PDHB(1)	3992015	77	41	76	32	47	8	2	10	10	0	0.0769	1.000	1.000
345	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10B(3), ALG12(1), ALG13(3), ALG2(3), ALG3(1), ALG5(1), ALG8(2), ALG9(3), B4GALT2(2), B4GALT3(1), DDOST(1), DOLPP1(3), DPAGT1(1), DPM1(1), FUT8(4), GANAB(4), MAN1A1(8), MAN1A2(3), MAN1B1(2), MAN1C1(4), MAN2A1(6), MGAT3(8), MGAT4A(5), MGAT5(1), MGAT5B(6), RPN2(2), ST6GAL1(4), STT3B(2)	6499552	87	41	85	55	59	11	2	6	9	0	0.690	1.000	1.000
346	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(16), ARHGEF1(1), F2(6), F2R(3), GNA12(2), GNA13(1), GNAQ(1), PIK3CA(2), PIK3R1(2), PLCB1(29), PPP1R12B(5), PRKCA(5), PTK2B(7), ROCK1(2)	3966932	82	41	81	36	62	6	2	7	5	0	0.124	1.000	1.000
347	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(2), UCHL1(4), UCHL3(1), UGT1A1(1), UGT1A10(10), UGT1A3(6), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(7), UGT1A8(2), UGT1A9(5), UGT2B15(16), UGT2B4(18)	2726872	85	41	79	44	59	7	5	4	10	0	0.248	1.000	1.000
348	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(11), AXIN1(6), CREBBP(12), CTNNB1(5), EP300(7), FZD1(1), GSK3B(1), HDAC1(1), LDB1(1), LEF1(1), PITX2(1), TRRAP(21), WNT1(1)	5111888	69	41	68	43	39	6	6	8	10	0	0.939	1.000	1.000
349	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(3), CALM2(1), GNAQ(1), GRB2(2), JUN(1), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAPK1(2), MAPK14(4), MAPK3(1), PAK1(2), PLCG1(4), PRKCA(5), PTK2B(7), RAC1(7), RAF1(2), SOS1(4), SYT1(11)	4361149	69	41	65	39	50	5	3	7	4	0	0.620	1.000	1.000
350	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ARHGAP1(1), ARHGAP4(1), ARHGAP5(7), ARHGAP6(4), ARHGEF1(1), ARHGEF11(9), ARHGEF5(8), ARPC1B(1), ARPC2(1), ARPC3(1), BAIAP2(2), DIAPH1(4), GSN(3), LIMK1(4), MYL2(4), MYLK(17), OPHN1(2), PIP5K1A(6), PIP5K1B(11), PPP1R12B(5), ROCK1(2), TLN1(10), VCL(4)	6907034	110	41	108	51	78	8	5	14	5	0	0.122	1.000	1.000
351	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(3), ABAT(5), ADSL(6), AGXT(8), AGXT2(10), ASL(2), ASNS(4), ASPA(2), CAD(11), CRAT(4), DARS(2), DDO(2), GAD1(6), GAD2(3), GOT1(4), GOT2(2), GPT(3), NARS(1), PC(5)	4025494	83	40	81	44	57	9	6	8	3	0	0.217	1.000	1.000
352	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(11), CREB5(7), DAG1(3), EPHB2(15), FOS(1), GNAQ(1), ITPKB(4), JUN(1), MAP2K4(3), MAP2K7(2), MAPK1(2), MAPK10(5), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1)	4359927	67	40	67	41	45	5	3	7	7	0	0.809	1.000	1.000
353	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(16), AKT1(1), BAX(1), BCL2(2), CSF2RB(8), IGF1(6), IGF1R(5), IL3(2), IL3RA(4), KIT(7), KITLG(6), PIK3CA(2), PIK3R1(2), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3)	3358560	75	39	75	40	52	5	3	7	8	0	0.298	1.000	1.000
354	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(10), CD2(13), CD33(9), CD5(3), CSF2(2), IFNB1(4), IFNG(2), IL10(1), IL12A(2), IL12B(3), IL13(2), IL3(2), IL4(1), IL5(4), ITGAX(10), TLR2(8), TLR4(21), TLR7(3), TLR9(7)	2850547	107	39	103	56	80	10	1	6	10	0	0.0119	1.000	1.000
355	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(7), DIAPH1(4), FYN(4), GSN(3), ITGA1(14), ITGB1(3), MAP2K1(3), MAPK1(2), MAPK3(1), MYL2(4), MYLK(17), PIK3CA(2), PIK3R1(2), PTK2(2), PXN(3), RAF1(2), ROCK1(2), TLN1(10)	5737073	85	39	81	40	62	8	3	10	2	0	0.262	1.000	1.000
356	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(16), F2(6), F2R(3), FGA(19), FGB(6), FGG(3), PLAT(2), PLAU(2), PLG(14), SERPINB2(7), SERPINE1(2)	2050111	80	39	78	35	63	5	3	4	5	0	0.220	1.000	1.000
357	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(1), CABIN1(1), CALM2(1), CAMK1(4), CAMK1G(8), HDAC5(3), IGF1(6), IGF1R(5), INSR(11), MAP2K6(2), MAPK14(4), MAPK7(2), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), NFATC1(9), NFATC2(4), PIK3CA(2), PIK3R1(2), PPP3CA(4), PPP3CB(1), SYT1(11)	5357281	89	39	89	53	65	6	2	13	3	0	0.633	1.000	1.000
358	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(5), ADC(2), ALDH4A1(4), ALDH5A1(7), CAD(11), CPS1(12), EPRS(4), GAD1(6), GAD2(3), GCLC(3), GCLM(1), GFPT1(1), GFPT2(2), GLS(1), GLS2(3), GLUD1(1), GMPS(3), GOT1(4), GOT2(2), GPT(3), GSR(2), GSS(3), NADSYN1(1), QARS(6)	6073421	90	39	88	55	56	9	8	12	5	0	0.679	1.000	1.000
359	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLA2(6), POLD1(2), POLD2(1), POLD3(3), POLE(9), POLE2(1), POLG(4), POLG2(4), POLH(2), POLK(3), POLL(6), POLM(1), POLQ(12), PRIM1(1), PRIM2(8), REV1(3), REV3L(7)	6226887	74	39	74	27	42	5	5	13	9	0	0.172	1.000	1.000
360	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(18), ACE2(3), AGT(3), AGTR1(6), AGTR2(2), ANPEP(10), CMA1(3), CPA3(10), CTSA(2), CTSG(4), ENPEP(17), LNPEP(9), MAS1(1), MME(11), NLN(1), REN(7), THOP1(3)	3227518	110	39	108	62	80	12	3	5	10	0	0.253	1.000	1.000
361	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(2), GALNT10(2), GALNT2(4), GALNT3(2), GALNT4(2), GALNT6(11), GALNT7(4), GALNT8(14), GCNT1(4), ST3GAL1(5), WBSCR17(20)	2228095	70	39	68	32	53	5	1	5	6	0	0.149	1.000	1.000
362	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K4(3), MAP2K7(2), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(2), MAPK14(4), MAPK3(1), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(1), NFKBIL1(3), PIK3CA(2), PIK3CD(2), PIK3R1(2), SYT1(11), TRAF2(1), TRAF3(3), TRAF5(4), TRAF6(2)	5127456	68	39	68	50	46	6	4	9	3	0	0.866	1.000	1.000
363	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(3), CASP7(3), CASP8(1), CFLAR(3), DAXX(4), DFFA(1), DFFB(2), FAF1(3), JUN(1), LMNA(3), LMNB2(4), MAP2K4(3), PAK1(2), PAK2(2), PRKDC(11), PTPN13(7), RB1(3), RIPK2(1), SPTAN1(2)	6319986	60	38	60	29	29	7	9	12	1	2	0.554	1.000	1.000
364	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(1), GHR(14), GRB2(2), INSR(11), IRS1(2), JAK2(6), MAP2K1(3), MAPK1(2), MAPK3(1), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(5), PTPN6(1), RAF1(2), RPS6KA1(2), SLC2A4(2), SOS1(4), SRF(1), STAT5A(2), STAT5B(2)	5097085	71	38	70	41	47	6	3	11	4	0	0.652	1.000	1.000
365	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), GALNS(1), GBA(2), GLB1(5), GUSB(2), HEXA(4), HEXB(2), HGSNAT(2), HPSE(5), HPSE2(3), HYAL2(1), IDS(3), IDUA(3), LCT(24), MAN2B1(5), MAN2B2(3), MANBA(2), NAGLU(2), NEU1(4), NEU2(10), NEU3(2), NEU4(5), SPAM1(11)	5238108	102	38	102	61	77	8	2	8	7	0	0.542	1.000	1.000
366	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(3), AASDH(4), AASDHPPT(1), AASS(1), ACAT2(1), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH9A1(2), BBOX1(3), DOT1L(4), EHHADH(5), EHMT1(5), EHMT2(3), GCDH(3), HADHA(7), PLOD1(1), PLOD2(3), PLOD3(1), SHMT2(2), TMLHE(1)	5652509	71	38	70	37	45	9	2	9	6	0	0.350	1.000	1.000
367	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(1), EIF4A1(3), EIF4A2(2), EIF4B(1), EIF4G1(6), EIF4G2(2), EIF4G3(7), FKBP1A(2), MKNK1(5), PDK2(4), PDPK1(1), PIK3CA(2), PIK3R1(2), PPP2CA(1), PTEN(11), RPS6(1), RPS6KB1(1), TSC1(3), TSC2(6)	4257245	61	38	61	25	31	6	5	7	12	0	0.426	1.000	1.000
368	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(5), CCR2(6), CCR3(7), CCR4(4), CCR5(4), CCR7(2), CD4(3), CSF2(2), CXCR3(2), IFNG(2), IFNGR1(3), IFNGR2(2), IL12A(2), IL12B(3), IL12RB1(8), IL12RB2(3), IL18R1(13), IL2(4), IL4(1), IL4R(5), IL5(4), TGFB2(1), TGFB3(1)	3068840	87	38	86	46	64	8	0	6	9	0	0.0754	1.000	1.000
369	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(20), ATP5O(3), ATP6V0A1(3), ATP6V0A4(11), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(6), ATP6V1F(1), ATP6V1G3(5), ATP6V1H(4), ATP7A(1), ATP7B(12), COX10(3), COX5B(1), COX7B(1), COX8A(1), NDUFB6(2), NDUFS2(1), PPA2(2), SDHA(1), UQCRC1(1), UQCRFS1(1)	5905138	84	38	84	61	50	7	9	10	8	0	0.942	1.000	1.000
370	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(8), CDC25A(5), CDC25B(1), CDC25C(3), CDK4(2), CHEK1(1), MYT1(12), RB1(3), TP53(20)	2706098	55	38	52	22	32	1	2	7	11	2	0.372	1.000	1.000
371	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(6), EEF1B2(1), EEF2(1), EEF2K(2), EIF1AX(1), EIF2AK1(1), EIF2AK2(2), EIF2AK3(7), EIF2B1(5), EIF2B2(1), EIF2B3(3), EIF2B5(1), EIF2S1(1), EIF4A1(3), EIF4A2(2), EIF4G1(6), EIF4G3(7), ETF1(1), GSPT2(1), KIAA0664(3), PABPC1(3), PABPC3(6), PAIP1(4), SLC35A4(1)	6709074	69	38	65	33	40	4	2	10	13	0	0.631	1.000	1.000
372	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(4), AZIN1(1), BTG1(2), CLOCK(2), CRY1(3), CRY2(1), EIF4G2(2), ETV6(8), GFRA1(3), GSTM3(1), HERPUD1(1), HSPA8(2), KLF9(2), MYF6(6), NCKAP1(1), NCOA4(1), NR1D2(4), PER1(2), PER2(9), PIGF(1), PPP1R3C(2), PPP2CB(2), PURA(1), SF3A3(2), TOB1(2), TUBB3(3), UCP3(2), UGP2(1), ZFR(2)	5614615	73	37	73	42	46	6	3	11	7	0	0.912	1.000	1.000
373	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(3), CSNK1D(1), DRD1(7), DRD2(8), GRM1(7), PLCB1(29), PPP1CA(1), PPP2CA(1), PPP3CA(4), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3)	2446362	74	37	73	40	59	0	3	7	5	0	0.280	1.000	1.000
374	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(16), AKT1(1), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), GNAS(12), GRB2(2), MAPK1(2), MAPK14(4), MAPK3(1), PIK3CA(2), PIK3R1(2), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKCA(5), RAC1(7), RPS6KA1(2), RPS6KA5(3), SOS1(4)	4431883	87	37	84	47	63	5	3	9	7	0	0.577	1.000	1.000
375	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGF(14), EGFR(13), FOS(1), GRB2(2), JAK1(4), JUN(1), MAP2K1(3), MAP2K4(3), MAPK3(1), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(5), RAF1(2), RASA1(1), SOS1(4), SRF(1), STAT1(2), STAT3(6), STAT5A(2)	5740631	73	37	72	46	48	6	4	8	7	0	0.918	1.000	1.000
376	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(7), CSF1R(6), DDX20(6), E2F1(5), ETS1(3), ETS2(7), ETV3(3), FOS(1), HDAC5(3), JUN(1), NCOR2(14), RBL1(4), RBL2(2), SIN3A(2), SIN3B(7)	3993551	71	37	71	49	48	5	0	11	7	0	0.887	1.000	1.000
377	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(5), ALDH4A1(4), ALDH5A1(7), CAD(11), CPS1(12), EPRS(4), GAD1(6), GAD2(3), GCLC(3), GCLM(1), GFPT1(1), GLS(1), GLS2(3), GLUD1(1), GMPS(3), GOT1(4), GOT2(2), GPT(3), GSS(3), NADSYN1(1), QARS(6)	5106225	84	37	82	44	52	9	8	11	4	0	0.428	1.000	1.000
378	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(16), CALM2(1), FOS(1), GNAQ(1), GNAS(12), JUN(1), MAP2K1(3), MAPK3(1), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), PLCG1(4), PPP3CA(4), PPP3CB(1), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKCA(5), RAF1(2), SYT1(11)	5328890	97	37	96	59	74	7	4	6	6	0	0.733	1.000	1.000
379	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(13), PGAP1(2), PIGB(2), PIGC(1), PIGF(1), PIGG(9), PIGK(3), PIGL(2), PIGN(2), PIGO(6), PIGQ(5), PIGS(1), PIGT(1), PIGU(2), PIGV(4), PIGW(1), PIGX(1), PIGZ(1)	3680966	57	37	57	30	39	3	3	8	4	0	0.315	1.000	1.000
380	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(5), ALDOC(1), FBP1(1), GOT1(4), GOT2(2), GPT(3), MDH1(1), MDH2(1), ME1(11), ME3(6), PGK1(1), PGK2(15), PKLR(6), PKM2(4), TKT(5), TKTL1(1), TKTL2(14)	3119021	82	37	80	48	65	5	3	3	6	0	0.163	1.000	1.000
381	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(1), IFNB1(4), IKBKB(2), IL1A(2), IL1B(2), IL1R1(6), IL1RAP(2), IL1RN(5), IRAK2(8), IRAK3(5), JUN(1), MAP2K3(4), MAP2K6(2), MAP3K14(1), MAPK14(4), MYD88(1), NFKB1(1), NFKBIA(1), RELA(1), TGFB2(1), TGFB3(1), TNF(1), TOLLIP(1), TRAF6(2)	4525375	59	37	58	37	37	6	1	7	8	0	0.765	1.000	1.000
382	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(1), BCL2(2), CBL(4), CFLAR(3), E2F1(5), FOS(1), GRB2(2), IL2RA(4), IL2RB(6), IL2RG(2), IRS1(2), JAK1(4), JAK3(5), MAPK1(2), MAPK3(1), MYC(2), PIK3CA(2), PIK3R1(2), PPIA(1), PTPN6(1), RAF1(2), RPS6KB1(1), SOCS3(2), SOS1(4), STAT5A(2), STAT5B(2), SYK(9)	5523607	74	37	73	42	49	5	8	7	5	0	0.674	1.000	1.000
383	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(3), DAB1(26), FYN(4), LRP8(3), RELN(42), VLDLR(2)	2145157	80	37	77	37	61	4	2	7	6	0	0.461	1.000	1.000
384	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(3), ACTN1(2), ACTN2(14), ACTN3(5), CAPN1(1), ITGA1(14), ITGB1(3), ITGB3(7), PTK2(2), PXN(3), RAC1(7), SPTAN1(2), TLN1(10)	4324607	73	37	69	36	52	5	3	8	4	1	0.0993	1.000	1.000
385	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(16), CD3D(4), CD3E(2), CD4(3), CREBBP(12), CSK(1), GNAS(12), HLA-DRA(5), LCK(4), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PTPRC(18), ZAP70(4)	3473389	94	36	91	52	71	6	3	7	7	0	0.449	1.000	1.000
386	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(16), CD3D(4), CD3E(2), CD4(3), CREBBP(12), CSK(1), GNAS(12), HLA-DRA(5), LCK(4), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PTPRC(18), ZAP70(4)	3473389	94	36	91	52	71	6	3	7	7	0	0.449	1.000	1.000
387	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(2), CDT1(1), DIAPH2(2), MCM10(5), MCM2(7), MCM3(5), MCM4(2), MCM5(2), MCM6(2), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(1), ORC5L(1), ORC6L(2), PCNA(1), POLA2(6), POLD1(2), POLD2(1), POLD3(3), POLE(9), POLE2(1), PRIM1(1), RFC1(2), RFC3(1), RPA1(1), RPA4(2), UBC(3)	7788386	70	36	70	38	47	4	2	7	10	0	0.489	1.000	1.000
388	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(2), F2(6), F2R(3), F5(19), F7(2), FGA(19), FGB(6), FGG(3), PROC(7), PROS1(8), SERPINC1(5), TFPI(5)	2520474	85	36	82	38	63	7	4	5	6	0	0.278	1.000	1.000
389	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSD(1), ARSE(2), GAL3ST1(7), GALC(1), GBA(2), GLB1(5), LCT(24), NEU1(4), NEU2(10), NEU3(2), NEU4(5), PPAP2B(4), PPAP2C(5), SMPD1(1), SPTLC2(4)	3674244	77	36	75	58	62	6	1	5	3	0	0.922	1.000	1.000
390	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), AKR1B10(5), ALDOA(1), ALDOB(5), ALDOC(1), FBP1(1), FPGT(2), FUK(1), GMDS(2), GMPPA(1), GMPPB(1), HK1(1), HK2(4), HK3(10), KHK(1), LHPP(1), MPI(1), MTMR1(2), MTMR2(1), MTMR6(2), PFKFB1(1), PFKFB2(3), PFKFB3(2), PFKFB4(4), PFKL(2), PGM2(5), RDH12(1), RDH13(3), SORD(1), TSTA3(2)	5662822	69	36	68	46	50	8	3	3	5	0	0.452	1.000	1.000
391	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(10), ADC(2), AGMAT(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2), AOC2(5), AOC3(5), ASL(2), ASS1(2), CPS1(12), GATM(1), MAOA(2), MAOB(7), ODC1(2), OTC(2), SMS(1)	4472283	69	36	69	49	47	8	6	2	6	0	0.750	1.000	1.000
392	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT2(3), AGPAT3(3), AGPAT4(4), AGPS(1), CHPT1(1), ENPP6(8), PAFAH1B1(2), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(2), PLA2G12B(3), PLA2G2A(1), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(12), PLA2G4A(7), PLA2G6(7), PLD1(5), PLD2(2), PPAP2B(4), PPAP2C(5)	3588448	82	36	80	45	59	6	2	7	8	0	0.490	1.000	1.000
393	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(9), ABP1(10), AOC2(5), AOC3(5), CES1(11), CES7(7), DDHD1(3), MYST3(9), MYST4(11), NAT6(2), PLA1A(4), PNPLA3(1), PPME1(1), PRDX6(1), SH3GLB1(1)	3908609	80	36	79	39	63	4	6	2	5	0	0.398	1.000	1.000
394	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(22), AKT1(1), ATM(8), BAX(1), CDKN1A(1), CSNK1A1(1), CSNK1D(1), HIC1(1), IGFBP3(1), MDM2(2), NFKBIB(1), NQO1(1), TP53(20)	3197930	61	36	55	28	36	6	1	6	12	0	0.522	1.000	1.000
395	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(11), AXIN1(6), BTRC(3), CREBBP(12), CSNK1A1(1), CSNK1D(1), CTNNB1(5), FZD1(1), GSK3B(1), HDAC1(1), MYC(2), NLK(2), PPARD(1), PPP2CA(1), TLE1(2), WIF1(4), WNT1(1)	4478075	55	36	55	33	29	4	5	5	12	0	0.928	1.000	1.000
396	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(4), AKR1D1(9), CYP11A1(8), CYP11B1(7), CYP11B2(8), CYP17A1(4), CYP21A2(10), HSD11B1(6), HSD3B1(1), HSD3B2(9)	1510325	66	35	63	38	45	5	2	7	7	0	0.135	1.000	1.000
397	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(3), CRK(2), CXCL12(1), GNAQ(1), MAP2K1(3), MAPK1(2), MAPK3(1), NFKB1(1), PIK3C2G(20), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(5), PTK2(2), PTK2B(7), PXN(3), RAF1(2), RELA(1)	4217182	62	35	60	37	47	3	0	6	6	0	0.704	1.000	1.000
398	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(3), BCL2(2), BIRC2(4), BIRC3(5), CASP10(3), CASP7(3), CASP8(1), CASP9(2), CFLAR(3), CHUK(1), CYCS(1), DFFA(1), DFFB(2), GAS2(4), LMNA(3), MAP3K14(1), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(1), SPTAN1(2), TNFRSF10A(3), TNFRSF10B(1), TNFRSF25(3), TNFSF10(5), TRAF2(1)	5145053	58	35	58	41	38	6	7	6	1	0	0.887	1.000	1.000
399	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(4), AKR1D1(9), CYP11A1(8), CYP11B1(7), CYP11B2(8), CYP17A1(4), CYP21A2(10), HSD11B1(6), HSD3B1(1), HSD3B2(9)	1510325	66	35	63	38	45	5	2	7	7	0	0.135	1.000	1.000
400	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1L(3), GTF2A2(1), GTF2B(1), GTF2E2(4), GTF2F1(2), GTF2F2(2), GTF2H1(3), GTF2H3(1), GTF2H4(1), GTF2I(2), GTF2IRD1(4), TAF1(5), TAF1L(27), TAF2(2), TAF4(4), TAF5L(2), TAF6(2), TAF6L(2), TAF7(1), TAF7L(3), TAF9(1), TBPL2(1)	5583368	74	35	73	33	48	9	3	10	4	0	0.466	1.000	1.000
401	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(1), EIF2B5(1), EIF2S1(1), GSK3B(1), IGF1(6), IGF1R(5), INPPL1(9), PDK2(4), PDPK1(1), PIK3CA(2), PIK3R1(2), PPP2CA(1), PTEN(11), RPS6(1), RPS6KB1(1)	3019164	47	35	47	21	23	3	6	6	9	0	0.533	1.000	1.000
402	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(7), ARHGEF1(1), GNA12(2), GNA13(1), GNAQ(1), MYL2(4), MYLK(17), PLCB1(29), PPP1R12B(5), PRKCA(5), ROCK1(2)	3200411	74	35	71	31	59	3	2	6	4	0	0.141	1.000	1.000
403	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(1), PIK3CA(2), PIK3R1(2), PLCB1(29), PLCG1(4), PRKCA(5), VAV1(12)	1977653	55	35	54	26	46	2	0	4	3	0	0.312	1.000	1.000
404	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(4), GBA3(5), LPO(8), MPO(5), PRDX1(1), PRDX2(2), PRDX6(1), TPO(28), TYR(2)	1488167	56	35	54	31	44	4	1	2	5	0	0.293	1.000	1.000
405	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(3), ATM(8), BRCA1(6), CDKN1A(1), CHEK1(1), JUN(1), MDM2(2), MRE11A(2), NFKB1(1), NFKBIA(1), RAD50(3), RBBP8(2), RELA(1), TP53(20), TP73(4)	4561288	56	34	53	23	33	4	3	6	10	0	0.469	1.000	1.000
406	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(6), AGT(3), AGTR2(2), EDN1(6), EDNRA(3), EDNRB(3), EGF(14), EGFR(13), FOS(1), JUN(1), MYC(2), NFKB1(1), PLCG1(4), PRKCA(5), RELA(1)	3157363	65	34	64	43	49	4	2	6	4	0	0.763	1.000	1.000
407	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(14), EGFR(13), MAP2K1(3), MAPK14(4), NCOR2(14), RXRA(1), THRA(1), THRB(10)	2629409	60	34	59	34	44	5	1	7	3	0	0.614	1.000	1.000
408	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(5), ALDOC(1), DERA(1), FBP1(1), G6PD(2), GPI(2), H6PD(3), PFKL(2), PGD(2), PGLS(1), PGM1(2), PGM3(1), PRPS1(1), PRPS1L1(7), PRPS2(1), RBKS(3), TALDO1(3), TKT(5), TKTL1(1), TKTL2(14)	3726322	59	34	59	49	39	7	1	4	8	0	0.873	1.000	1.000
409	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(2), CREBBP(12), EP300(7), FYN(4), IL2RG(2), IL7(3), IL7R(15), JAK1(4), JAK3(5), LCK(4), PIK3CA(2), PIK3R1(2), PTK2B(7), STAT5A(2), STAT5B(2)	4284911	73	34	72	37	51	9	2	6	5	0	0.482	1.000	1.000
410	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(22), ABCB11(27), ABCB4(8), ABCC1(7), ABCC3(17)	2182141	81	34	77	40	57	5	1	5	13	0	0.0177	1.000	1.000
411	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(2), GTF2B(1), GTF2F1(2), HDAC3(3), NCOA1(5), NCOA2(10), NCOA3(7), NCOR2(14), POLR2A(8), RXRA(1), TBP(4)	3815883	57	34	56	27	44	3	3	4	3	0	0.354	1.000	1.000
412	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(4), DYRK1B(2), GLI2(20), GLI3(7), GSK3B(1), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), SHH(2), SMO(4), SUFU(1)	2544617	54	34	52	29	40	6	2	3	3	0	0.327	1.000	1.000
413	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(2), CNR1(7), CNR2(1), DNMT1(10), MTNR1A(6), MTNR1B(5), PTGDR(7), PTGER2(4), PTGFR(12), PTGIR(3), TBXA2R(3)	1712311	60	34	56	41	42	5	3	3	7	0	0.244	1.000	1.000
414	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(4), CSF1R(6), EGF(14), EGFR(13), GRB2(2), MET(7), PDGFRA(13), PRKCA(5), SH3GLB1(1), SH3KBP1(2)	2997125	67	33	67	48	46	3	3	7	8	0	0.954	1.000	1.000
415	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(5), ACO1(1), ACO2(1), CLYBL(1), CS(1), FH(3), IDH1(6), IDH3A(2), IDH3G(2), MDH1(1), MDH2(1), OGDH(7), OGDHL(22), PC(5), PCK1(15), PCK2(2), SDHA(1), SDHC(2)	4619220	78	33	74	41	59	3	4	6	6	0	0.242	1.000	1.000
416	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(13), CD38(3), ENPP1(7), ENPP3(8), NADK(2), NADSYN1(1), NMNAT2(2), NMNAT3(3), NNMT(7), NNT(3), NT5C1B(16), NT5C3(2), NT5E(3), NT5M(1), NUDT12(1), QPRT(4)	3315222	76	33	73	47	50	9	4	7	6	0	0.813	1.000	1.000
417	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(2), BAIAP2(2), CASP1(3), CASP7(3), CASP8(1), INSR(11), ITCH(2), MAGI1(16), MAGI2(14), RERE(11), WWP1(1), WWP2(3)	3705842	69	33	69	34	48	4	3	11	3	0	0.577	1.000	1.000
418	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(4), CD3D(4), CD3E(2), CXCR3(2), ETV5(4), IFNG(2), IL12A(2), IL12B(3), IL12RB1(8), IL12RB2(3), IL18(2), IL18R1(13), JAK2(6), JUN(1), MAP2K6(2), MAPK14(4), STAT4(12), TYK2(3)	2851714	77	33	77	35	60	5	2	7	3	0	0.224	1.000	1.000
419	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	CAT(3), EPX(4), LPO(8), MPO(5), PRDX1(1), PRDX2(2), PRDX6(1), SHMT2(2), TPO(28)	1823422	54	33	52	29	43	4	1	3	3	0	0.169	1.000	1.000
420	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(3), ADCY1(16), CDC25C(3), GNAS(12), MAPK1(2), MAPK3(1), MYT1(12), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), RPS6KA1(2)	3146067	64	33	64	42	52	2	2	4	4	0	0.603	1.000	1.000
421	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(12), EP300(7), IKBKB(2), IL1B(2), IL8(1), MAP2K3(4), MAP2K6(2), MAP3K14(1), MAPK11(1), MAPK14(4), MYD88(1), NFKB1(1), NFKBIA(1), NR3C1(1), RELA(1), TGFBR2(5), TLR2(8), TNF(1)	4568895	56	33	56	36	36	9	2	5	4	0	0.887	1.000	1.000
422	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(1), CAMK1(4), CAMK1G(8), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CAMK4(8), ESRRA(1), HDAC5(3), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), PPARA(3), PPP3CA(4), PPP3CB(1), SLC2A4(2), SYT1(11)	3078826	65	33	65	38	51	4	2	6	2	0	0.485	1.000	1.000
423	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(1), AKT2(6), AKT3(2), GRB2(2), MAPK1(2), MAPK3(1), PDK1(1), PIK3CA(2), PIK3CD(2), PTEN(11), PTK2B(7), RBL2(2), SOS1(4)	3154289	43	33	43	18	22	3	2	8	8	0	0.544	1.000	1.000
424	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(3), CARS(5), DARS(2), EPRS(4), GARS(4), HARS(2), IARS(1), KARS(2), LARS(8), LARS2(3), MARS(4), MARS2(3), NARS(1), QARS(6), RARS(4), SARS(4), TARS(1), WARS(3), WARS2(1)	4968601	61	32	60	20	38	5	4	7	7	0	0.0476	1.000	1.000
425	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(2), ACTN2(14), ACTN3(5), BCAR1(3), CSK(1), CTNNA1(2), CTNNA2(14), CTNNB1(5), PTK2(2), PXN(3), VCL(4)	2893298	55	32	55	34	36	1	1	10	6	1	0.598	1.000	1.000
426	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(16), ADRB2(1), CFTR(24), GNAS(12), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), SLC9A3R1(1)	1983658	67	32	64	40	51	3	3	6	4	0	0.548	1.000	1.000
427	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(2), ALOX15(4), ALOX15B(5), ALOX5(6), ALOX5AP(1), DPEP1(3), GGT1(3), LTA4H(2), PLA2G2A(1), PLA2G6(7), PTGDS(1), PTGIS(8), PTGS1(12), PTGS2(6), TBXAS1(7)	2290392	68	32	67	41	48	4	2	9	5	0	0.269	1.000	1.000
428	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(6), GABRA1(7), GABRA2(8), GABRA3(12), GABRA4(6), GABRA5(2), GABRA6(15), UBQLN1(3)	1797768	59	32	56	34	50	3	0	1	5	0	0.485	1.000	1.000
429	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(8), CYP2A13(4), CYP2A6(7), CYP2A7(5), NAT2(5), XDH(33)	1237848	62	32	61	39	52	0	5	2	3	0	0.157	1.000	1.000
430	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(6), ANAPC2(1), ANAPC5(3), ANAPC7(4), BTRC(3), CDC16(1), CDC27(5), CUL1(2), CUL2(2), CUL3(2), FBXW11(4), FBXW7(7), FZR1(1), ITCH(2), SMURF1(1), SMURF2(3), TCEB1(1), UBA1(2), UBE2D3(2), UBE2E2(2), VHL(1), WWP1(1), WWP2(3)	6126334	59	32	58	29	37	2	4	10	6	0	0.739	1.000	1.000
431	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(1), CS(1), DLAT(2), FH(3), IDH3A(2), IDH3G(2), MDH1(1), MDH2(1), OGDH(7), PC(5), PDHA1(1), PDHA2(7), PDHB(1), PDHX(2), PDK1(1), PDK2(4), PDK3(3), PDK4(5), PDP2(4), SDHA(1), SDHC(2)	4381761	56	32	56	25	38	2	4	5	7	0	0.227	1.000	1.000
432	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(16), ADRB2(1), GNAS(12), PLCE1(22), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3)	2238489	64	32	64	33	49	3	4	5	3	0	0.321	1.000	1.000
433	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(1), CASP2(1), CASP8(1), CRADD(1), DFFA(1), DFFB(2), JUN(1), LMNA(3), LMNB2(4), MADD(7), MAP2K4(3), PAK1(2), PAK2(2), PRKDC(11), RB1(3), RIPK1(1), SPTAN1(2), TNF(1), TNFRSF1A(2), TRAF2(1)	6000007	51	32	50	21	26	7	6	7	3	2	0.190	1.000	1.000
434	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(18), AGT(3), AGTR1(6), AGTR2(2), BDKRB2(2), KNG1(3), NOS3(11), REN(7)	1517668	52	31	50	39	36	4	1	4	7	0	0.639	1.000	1.000
435	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(5), CHAT(10), COMT(1), DBH(5), DDC(5), GAD1(6), GAD2(3), HDC(8), MAOA(2), PAH(3), PNMT(3), SLC18A3(2), TH(6), TPH1(1)	2172137	61	31	61	50	47	5	2	2	5	0	0.840	1.000	1.000
436	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(16), GNAS(12), PPP2CA(1), PRKAA1(1), PRKAA2(15), PRKAB2(1), PRKACB(2), PRKACG(5), PRKAG1(1), PRKAG2(2), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3)	2343498	62	31	61	31	50	2	3	3	4	0	0.332	1.000	1.000
437	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(3), EPHA4(9), EPHB1(13), FYN(4), ITGA1(14), ITGB1(3), L1CAM(3), LYN(1), SELP(13)	2423888	63	31	59	34	48	4	1	6	4	0	0.452	1.000	1.000
438	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(10), G6PD(2), GCLC(3), GCLM(1), GGT1(3), GPX1(2), GPX3(2), GPX5(6), GPX6(5), GSR(2), GSS(3), GSTA1(5), GSTA3(1), GSTA5(1), GSTK1(1), GSTM1(1), GSTM3(1), GSTM4(1), GSTM5(2), IDH1(6), MGST1(1), MGST2(1), OPLAH(8)	3352867	68	31	64	34	45	5	2	12	4	0	0.155	1.000	1.000
439	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GALNS(1), GLB1(5), GUSB(2), HEXA(4), HEXB(2), HGSNAT(2), HPSE(5), HPSE2(3), HYAL2(1), IDS(3), IDUA(3), LCT(24), NAGLU(2), SPAM1(11)	3119654	68	31	68	41	49	5	1	6	7	0	0.602	1.000	1.000
440	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(4), GBA(2), GBA3(5), LPO(8), MPO(5), PRDX6(1), TPO(28)	1291939	53	31	51	31	43	4	1	2	3	0	0.271	1.000	1.000
441	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(7), POLR1B(4), POLR1C(1), POLR2A(8), POLR2B(10), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2L(1), POLR3A(2), POLR3B(10), POLR3GL(1), POLR3K(1)	3616531	50	31	50	20	29	8	3	6	4	0	0.192	1.000	1.000
442	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	FOS(1), GRB2(2), JAK1(4), JUN(1), MAP2K1(3), MAP2K4(3), MAPK3(1), PDGFA(1), PDGFRA(13), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(5), RAF1(2), RASA1(1), SOS1(4), SRF(1), STAT1(2), STAT3(6), STAT5A(2)	5344606	60	31	59	36	38	5	4	7	6	0	0.831	1.000	1.000
443	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(11), CDH1(4), CREBBP(12), EP300(7), MAP2K1(3), MAPK3(1), SKIL(1), TGFB2(1), TGFB3(1), TGFBR2(5)	3952713	46	31	45	21	29	5	1	3	8	0	0.694	1.000	1.000
444	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(12), HLA-DRA(5), IFNG(2), IFNGR1(3), IFNGR2(2), IL12A(2), IL12B(3), IL12RB1(8), IL12RB2(3), IL18(2), IL18R1(13), IL2(4), IL2RA(4), IL4(1), IL4R(5)	1948541	69	31	68	27	53	5	0	3	8	0	0.0627	1.000	1.000
445	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM2(1), CHUK(1), EGR2(3), EGR3(1), GNAQ(1), MYC(2), NFATC1(9), NFATC2(4), NFKB1(1), NFKBIA(1), PLCG1(4), PPP3CA(4), PPP3CB(1), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), RELA(1), SYT1(11), VIP(3), VIPR2(3)	4277774	64	31	64	48	50	4	4	4	2	0	0.944	1.000	1.000
446	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), GLB1(5), HEXA(4), HEXB(2), LCT(24), MAN2B1(5), MAN2B2(3), MANBA(2), NEU1(4), NEU2(10), NEU3(2), NEU4(5)	3117846	67	30	67	40	53	6	1	6	1	0	0.540	1.000	1.000
447	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(3), EPX(4), LPO(8), MPO(5), MTHFR(1), PRDX6(1), SHMT2(2), TPO(28)	1801603	52	30	50	31	42	4	1	3	2	0	0.283	1.000	1.000
448	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(2), ACOX1(3), ACOX3(5), ELOVL2(2), ELOVL6(2), FADS2(2), FASN(9), HADHA(7), SCD(2)	2198991	34	30	34	20	22	4	0	4	4	0	0.362	1.000	1.000
449	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	FOS(1), GRB2(2), IL2(4), IL2RA(4), IL2RB(6), IL2RG(2), JAK1(4), JAK3(5), JUN(1), LCK(4), MAP2K1(3), MAPK3(1), RAF1(2), SOS1(4), STAT5A(2), STAT5B(2), SYK(9)	3526803	56	30	54	30	40	3	3	5	5	0	0.472	1.000	1.000
450	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(8), ATR(13), CDC25C(3), CHEK1(1), TP53(20)	2459521	45	30	42	17	26	1	3	5	10	0	0.491	1.000	1.000
451	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(13), CD3D(4), CD3E(2), CD4(3), ICAM1(2), ITGAL(15), ITGB2(8), PTPRC(18)	1706421	65	30	60	35	51	3	0	4	7	0	0.199	1.000	1.000
452	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(7), GABRA2(8), GABRA3(12), GABRA4(6), GABRA5(2), GABRA6(15), GPX1(2), PRKCE(3)	1181592	55	29	52	28	43	5	0	3	4	0	0.281	1.000	1.000
453	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(1), BCL2(2), BCR(6), FOS(1), GRB2(2), JAK2(6), JUN(1), MAP2K1(3), MAP2K4(3), MAPK3(1), MYC(2), PIK3CA(2), PIK3R1(2), RAF1(2), SOS1(4), STAT1(2), STAT5A(2), STAT5B(2)	4289561	44	29	43	25	26	6	4	6	2	0	0.745	1.000	1.000
454	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(4), ASRGL1(1), CA1(6), CA12(3), CA13(4), CA2(4), CA3(3), CA4(1), CA5A(1), CA5B(1), CA6(2), CA8(3), CA9(3), CPS1(12), GLS(1), GLS2(3), GLUD1(1), HAL(8)	3234425	62	29	62	28	50	4	2	4	2	0	0.199	1.000	1.000
455	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG5(1), ATG7(4), GABARAPL1(1), IFNA10(1), IFNA14(4), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(6), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(2), IFNG(2), PIK3R4(2), PRKAA1(1), PRKAA2(15), ULK1(4), ULK2(4), ULK3(1)	3216335	62	29	60	33	49	2	4	5	2	0	0.373	1.000	1.000
456	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(4), CA1(6), CA12(3), CA2(4), CA3(3), CA4(1), CA5A(1), CA5B(1), CA6(2), CA8(3), CA9(3), CPS1(12), GLS(1), GLS2(3), GLUD1(1), HAL(8)	2890438	57	29	57	26	45	4	2	4	2	0	0.229	1.000	1.000
457	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(3), ATP6V0A1(3), ATP6V0A4(11), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(6), ATP6V1F(1), ATP6V1G3(5), ATP6V1H(4), FDXR(6)	2467243	43	29	43	29	23	3	2	8	7	0	0.770	1.000	1.000
458	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(1), BCAR1(3), GRB2(2), ITGB1(3), MAPK1(2), MAPK3(1), PDK2(4), PDPK1(1), PIK3CA(2), PIK3R1(2), PTEN(11), PTK2(2), SOS1(4)	2937729	38	29	38	17	18	2	2	8	8	0	0.765	1.000	1.000
459	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(1), AKT2(6), AKT3(2), BCL2(2), GRB2(2), GSK3B(1), IL4R(5), IRS1(2), JAK1(4), JAK3(5), MAP4K1(3), MAPK1(2), MAPK3(1), PDK1(1), PIK3CA(2), PIK3CD(2), PIK3R1(2), PPP1R13B(3), RAF1(2), SOS1(4), SOS2(3), STAT6(2)	5600829	57	29	57	32	37	10	2	5	3	0	0.655	1.000	1.000
460	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC2(4), BIRC3(5), CASP8(1), CFLAR(3), JUN(1), MAP2K4(3), MAP3K3(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(1), NFKBIL1(3), NR2C2(2), RALBP1(1), RIPK1(1), TNF(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(1)	4158233	40	29	40	23	18	5	6	9	2	0	0.697	1.000	1.000
461	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(3), ACTR2(2), ARPC1B(1), ARPC2(1), ARPC3(1), NCKAP1(1), NTRK1(9), RAC1(7), WASF1(1), WASF2(4), WASF3(9), WASL(1)	2351805	40	28	36	15	32	1	2	2	3	0	0.246	1.000	1.000
462	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(3), ATP6V0A1(3), ATP6V0A4(11), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(6), ATP6V1F(1), ATP6V1G3(5), ATP6V1H(4)	2319392	37	28	37	26	19	3	2	7	6	0	0.822	1.000	1.000
463	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(5), ALDOC(1), FBP1(1), GOT1(4), GOT2(2), GPT(3), MDH1(1), MDH2(1), ME1(11), ME2(1), ME3(6), PGK1(1), PKLR(6), PKM2(4), TKT(5)	2785026	53	28	53	28	39	3	3	3	5	0	0.163	1.000	1.000
464	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(3), ATP6V0A1(3), ATP6V0A4(11), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(6), ATP6V1F(1), ATP6V1G3(5), ATP6V1H(4)	2319392	37	28	37	26	19	3	2	7	6	0	0.822	1.000	1.000
465	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(1), AKT1(1), ANXA1(3), CALM2(1), GNAS(12), NFKB1(1), NOS3(11), NPPA(1), NR3C1(1), PIK3CA(2), PIK3R1(2), RELA(1), SYT1(11)	2724358	48	28	47	31	40	2	2	3	1	0	0.829	1.000	1.000
466	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(10), G6PD(2), GCLC(3), GCLM(1), GGT1(3), GPX1(2), GPX3(2), GPX5(6), GSS(3), GSTA1(5), GSTA3(1), GSTM1(1), GSTM3(1), GSTM4(1), GSTM5(2), IDH1(6), MGST1(1), MGST2(1), PGD(2)	2776425	53	28	49	26	34	4	2	10	3	0	0.209	1.000	1.000
467	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(7), CHIT1(4), CTBS(2), GFPT1(1), GFPT2(2), GNE(2), HEXA(4), HEXB(2), HK1(1), HK2(4), HK3(10), LHPP(1), MTMR1(2), MTMR2(1), MTMR6(2), PGM3(1), UAP1(1)	4401449	48	28	47	29	31	4	3	5	5	0	0.662	1.000	1.000
468	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(12), CPT1A(6), LEP(1), LEPR(10), PRKAA1(1), PRKAA2(15), PRKAB2(1), PRKAG1(1), PRKAG2(2)	2250249	49	28	47	31	40	2	1	2	4	0	0.843	1.000	1.000
469	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(1), IKBKB(2), IL1A(2), IL1R1(6), MAP3K14(1), MYD88(1), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(1), TLR4(21), TNF(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(1), TRAF6(2)	3675056	45	28	44	31	32	2	2	4	5	0	0.861	1.000	1.000
470	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(4), CD2(13), CD3D(4), CD3E(2), CD4(3), CXCR3(2), IFNG(2), IL12A(2), IL12B(3), IL12RB1(8), IL12RB2(3), JAK2(6), STAT4(12), TYK2(3)	2232733	67	28	65	39	50	6	2	6	3	0	0.515	1.000	1.000
471	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(5), ALDOC(1), FBP1(1), G6PD(2), GPI(2), H6PD(3), PGD(2), PGLS(1), PGM1(2), PGM3(1), PRPS1(1), PRPS1L1(7), PRPS2(1), RBKS(3), TAL1(4), TALDO1(3), TKT(5)	3139877	45	28	45	40	28	5	1	5	6	0	0.939	1.000	1.000
472	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(18), CD44(4), CSF1(7), FCGR3A(3), IL1B(2), IL6R(2), SELL(5), SPN(3), TGFB2(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF8(9), TNFSF8(2)	1983619	60	28	59	26	47	4	2	1	6	0	0.0614	1.000	1.000
473	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6R(2), JAK1(4), JAK2(6), JAK3(5), PIAS3(3), PTPRU(11), REG1A(4), STAT3(6)	2330641	42	28	42	20	26	4	2	5	5	0	0.242	1.000	1.000
474	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(5), APOA1(1), APOA4(4), APOC1(1), CETP(2), CYP7A1(4), HMGCR(7), LDLR(9), LIPC(5), LPL(2), LRP1(14), SCARB1(3), SOAT1(1)	4264809	58	28	57	37	39	4	3	6	6	0	0.573	1.000	1.000
475	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(2), CASP2(1), CHUK(1), CRADD(1), IKBKB(2), JUN(1), LTA(2), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP3K14(1), MAP4K2(4), MAPK14(4), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(1), TNF(1), TNFRSF1A(2), TRAF2(1)	3650855	36	28	36	28	22	5	2	3	4	0	0.925	1.000	1.000
476	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(3), ATP6V0A1(3), ATP6V0A4(11), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(6), ATP6V1F(1), ATP6V1G3(5), ATP6V1H(4)	2319392	37	28	37	26	19	3	2	7	6	0	0.822	1.000	1.000
477	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(2), CREBBP(12), EP300(7), NCOA3(7), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), RXRA(1)	3188314	42	27	42	23	28	3	1	6	4	0	0.752	1.000	1.000
478	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3D(4), CD3E(2), CD86(12), CTLA4(1), GRB2(2), HLA-DRA(5), ICOS(2), IL2(4), ITK(15), LCK(4), PIK3CA(2), PIK3R1(2), PTPN11(3)	1965520	58	27	56	29	42	4	1	3	8	0	0.581	1.000	1.000
479	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(1), ALDOB(5), ALDOC(1), FBP1(1), FPGT(2), GCK(8), GMDS(2), GMPPA(1), GMPPB(1), HK1(1), HK2(4), HK3(10), KHK(1), MPI(1), PFKFB1(1), PFKFB3(2), PFKFB4(4), SORD(1)	3657790	49	27	48	37	37	6	2	1	3	0	0.595	1.000	1.000
480	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(12), ACACB(12), FASN(9), OLAH(6), OXSM(1)	2431756	40	27	40	24	28	4	1	3	4	0	0.472	1.000	1.000
481	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(1), GLB1(5), HEXA(4), HEXB(2), LCT(24), SLC33A1(3), ST3GAL1(5), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC5(4), ST6GALNAC6(1), ST8SIA5(3)	2536315	57	27	57	33	41	5	0	8	3	0	0.475	1.000	1.000
482	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(1), ACOT11(5), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(2), EHHADH(5), GCDH(3), HADHA(7), MYST3(9), MYST4(11), NAT6(2), PNPLA3(1), SH3GLB1(1)	4024428	55	27	53	36	36	7	1	8	3	0	0.913	1.000	1.000
483	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(25), CYP2C9(24)	309583	49	27	46	29	42	2	2	0	3	0	0.420	1.000	1.000
484	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(11), AP2A1(1), BIN1(1), CALM2(1), DNM1(6), EPN1(4), EPS15(1), PICALM(1), PPP3CA(4), PPP3CB(1), SYNJ1(8), SYNJ2(9), SYT1(11)	3281840	59	27	59	30	46	4	2	6	1	0	0.456	1.000	1.000
485	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(13), CD38(3), ENPP1(7), ENPP3(8), NADSYN1(1), NMNAT2(2), NNMT(7), NNT(3), NT5E(3), NT5M(1), QPRT(4)	2241413	52	27	49	25	37	7	2	3	3	0	0.356	1.000	1.000
486	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(1), APC(11), AXIN1(6), BTRC(3), CTNNB1(5), DLL1(2), FZD1(1), GSK3B(1), NOTCH1(3), WNT1(1)	3236667	34	27	34	24	16	4	3	3	8	0	0.957	1.000	1.000
487	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	FOS(1), GRB2(2), JAK2(6), JUN(1), MAP2K1(3), MAPK3(1), MPL(1), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(5), RAF1(2), RASA1(1), SOS1(4), STAT1(2), STAT3(6), STAT5A(2), STAT5B(2), THPO(3)	4586222	50	27	49	30	31	5	3	7	4	0	0.850	1.000	1.000
488	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(1), CAMK1(4), CAMK1G(8), CAMK2A(4), CAMK2B(1), CAMK2D(4), CAMK2G(2), CAMK4(8), CAMKK1(1), CAMKK2(3), SYT1(11)	1786213	47	26	47	32	36	4	2	3	2	0	0.682	1.000	1.000
489	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), ACO2(1), CS(1), FH(3), IDH1(6), IDH3A(2), IDH3G(2), MDH1(1), MDH2(1), PC(5), PCK1(15), SDHA(1)	3194631	39	26	35	25	29	1	3	3	3	0	0.644	1.000	1.000
490	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(1), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K6(2), MAPK1(2), MAPK14(4), MAPK3(1), NFKB1(1), PIK3CA(2), PIK3R1(2), RB1(3), RELA(1), SP1(3)	2962379	31	26	30	23	18	3	2	2	4	2	0.965	1.000	1.000
491	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(1), B3GAT2(1), B3GAT3(3), CHPF(2), CHST11(4), CHST12(1), CHST13(1), CHST14(2), CHSY1(5), DSE(8), XYLT1(8), XYLT2(1)	2037811	37	26	37	29	24	6	2	4	1	0	0.743	1.000	1.000
492	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(3), ACOX3(5), FADS2(2), PLA2G12B(3), PLA2G2A(1), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(12), PLA2G4A(7), PLA2G6(7)	1558193	49	26	49	29	36	5	0	4	4	0	0.445	1.000	1.000
493	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(4), IL22(1), IL22RA1(5), IL22RA2(1), JAK1(4), JAK2(6), JAK3(5), SOCS3(2), STAT1(2), STAT3(6), STAT5A(2), STAT5B(2), TYK2(3)	2794806	43	26	43	26	26	4	6	5	2	0	0.613	1.000	1.000
494	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(3), CSF1(7), CSF2(2), CSF3(1), HLA-DRA(5), IFNB1(4), IFNG(2), IL10(1), IL11(2), IL12A(2), IL12B(3), IL13(2), IL15(1), IL1A(2), IL2(4), IL3(2), IL4(1), IL5(4), IL7(3), IL8(1), LTA(2), PDGFA(1), TGFB2(1), TGFB3(1), TNF(1)	2020775	58	26	57	33	43	6	0	2	7	0	0.140	1.000	1.000
495	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	FOS(1), GRB2(2), INSR(11), IRS1(2), JUN(1), MAP2K1(3), MAPK3(1), PIK3CA(2), PIK3R1(2), PTPN11(3), RAF1(2), RASA1(1), SLC2A4(2), SOS1(4), SRF(1)	3930415	38	26	37	22	21	4	1	10	2	0	0.849	1.000	1.000
496	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH9A1(2), EHHADH(5), HADHA(7)	1866123	35	26	34	15	20	5	1	5	4	0	0.179	1.000	1.000
497	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(1), CALM2(1), CAPN2(2), EP300(7), HDAC1(1), MEF2D(2), NFATC1(9), NFATC2(4), PPP3CA(4), PPP3CB(1), PRKCA(5), SYT1(11)	3774805	48	26	48	28	36	4	3	3	2	0	0.666	1.000	1.000
498	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), GLB1(5), HEXA(4), HEXB(2), LCT(24), MANBA(2), NEU1(4), NEU2(10), NEU3(2), NEU4(5)	2530812	59	26	59	35	46	5	1	6	1	0	0.630	1.000	1.000
499	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(1), CCNE1(1), CDK4(2), CDKN1A(1), E2F1(5), MAPK1(2), MAPK3(1), NFKB1(1), NFKBIA(1), PAK1(2), PIK3CA(2), PIK3R1(2), RAC1(7), RAF1(2), RB1(3), RELA(1)	3092765	34	26	31	22	23	3	1	3	2	2	0.785	1.000	1.000
500	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(3), BIRC2(4), BIRC3(5), CASP10(3), CASP7(3), CASP8(1), CASP9(2), DFFA(1), DFFB(2), GZMB(1), PRF1(5), SCAP(4), SREBF1(2), SREBF2(6)	2795501	42	26	42	18	25	4	5	5	3	0	0.221	1.000	1.000
501	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(1), AKT2(6), AKT3(2), CDKN1A(1), GRB2(2), MAP2K1(3), MAP2K2(2), NGFR(6), NTRK1(9), PIK3CA(2), PIK3CD(2), SOS1(4)	2438395	40	26	39	16	24	6	2	5	3	0	0.234	1.000	1.000
502	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(5), CHUK(1), IFNG(2), IKBKB(2), IL2(4), IL4(1), JUN(1), MAP3K5(9), MAP4K5(2), MAPK14(4), NFKB1(1), NFKBIA(1), RELA(1), TNFRSF9(2), TNFSF9(1), TRAF2(1)	2938628	38	25	38	21	24	2	1	5	6	0	0.711	1.000	1.000
503	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(1), CHRNG(1), MUSK(18), PIK3CA(2), PIK3R1(2), PTK2(2), PTK2B(7), RAPSN(1), TERT(4)	2497676	38	25	37	38	30	2	0	5	1	0	0.985	1.000	1.000
504	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(18), MAP2(4), PPP1CA(1), PPP2CA(1), PRKACB(2), PRKACG(5), PRKAG1(1), PRKAR2A(1), PRKAR2B(3), PRKCE(3)	2778049	39	25	39	19	25	3	1	4	6	0	0.642	1.000	1.000
505	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(8), FOS(1), GRB2(2), IL3(2), IL3RA(4), JAK2(6), MAP2K1(3), MAPK3(1), PTPN6(1), RAF1(2), SOS1(4), STAT5A(2), STAT5B(2)	2696198	38	25	37	23	23	2	2	5	6	0	0.708	1.000	1.000
506	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(12), EP300(7), LPL(2), NCOA1(5), NCOA2(10), PPARG(6), RXRA(1)	2867268	43	25	42	18	32	4	1	3	3	0	0.441	1.000	1.000
507	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(4), CD3E(2), CD4(3), FYN(4), HLA-DRA(5), LCK(4), PTPRC(18), ZAP70(4)	1352543	44	25	41	26	34	4	0	4	2	0	0.578	1.000	1.000
508	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(3), ARHGDIB(1), BIRC2(4), BIRC3(5), CASP1(3), CASP10(3), CASP2(1), CASP4(1), CASP7(3), CASP8(1), CASP9(2), CYCS(1), DFFA(1), DFFB(2), GZMB(1), LMNA(3), LMNB2(4), PRF1(5)	3011786	44	24	44	14	26	7	4	6	1	0	0.0536	1.000	1.000
509	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(14), EGFR(13), ERBB3(2), NRG1(9)	1592880	38	24	38	22	29	1	1	4	3	0	0.797	1.000	1.000
510	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(8), IL13(2), IL4(1), IL5(4), MAF(1), MAP2K3(4), MAPK14(4), NFATC1(9), NFATC2(4), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3)	1849188	50	24	48	27	36	6	1	3	4	0	0.276	1.000	1.000
511	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(3), CYP11A1(8), CYP11B2(8), CYP17A1(4), HSD11B1(6), HSD3B1(1), HSD3B2(9)	1060122	39	24	38	34	28	3	0	3	5	0	0.614	1.000	1.000
512	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(2), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(2), HEMK1(1), LCMT1(3), METTL2B(5), PRMT2(1), PRMT3(3), PRMT5(3), PRMT6(1), PRMT7(1), PRMT8(7)	2322131	37	24	36	22	24	6	1	4	2	0	0.576	1.000	1.000
513	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	FOS(1), GRB2(2), IGF1(6), IGF1R(5), IRS1(2), JUN(1), MAP2K1(3), MAPK3(1), PIK3CA(2), PIK3R1(2), PTPN11(3), RAF1(2), RASA1(1), SOS1(4), SRF(1)	3798856	36	24	35	22	24	3	1	6	2	0	0.852	1.000	1.000
514	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM2(1), CDKN1A(1), GNAQ(1), MARCKS(1), NFATC1(9), NFATC2(4), NFATC3(5), NFATC4(3), PLCG1(4), PPP3CA(4), PPP3CB(1), PRKCA(5), SP1(3), SP3(1), SYT1(11)	3218386	54	23	54	30	40	6	3	2	3	0	0.642	1.000	1.000
515	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(8), CDC25A(5), CDC25B(1), CDC25C(3), CHEK1(1), MYT1(12)	2118623	30	23	29	20	23	1	1	2	3	0	0.879	1.000	1.000
516	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(2), ARPC1B(1), ARPC2(1), ARPC3(1), PAK1(2), PDGFRA(13), PIK3CA(2), PIK3R1(2), RAC1(7), WASL(1)	2068513	32	23	29	13	23	1	2	3	3	0	0.412	1.000	1.000
517	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(16), FHL5(5), FSHB(2), FSHR(9), GNAS(12)	1452160	44	23	43	28	34	2	2	3	3	0	0.772	1.000	1.000
518	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(1), EGF(14), EGFR(13), HGS(1), TF(4), TFRC(3)	1974307	36	23	36	24	26	1	3	3	3	0	0.865	1.000	1.000
519	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	RPL10L(5), RPL11(1), RPL14(1), RPL18(2), RPL18A(1), RPL21(1), RPL26(1), RPL27(2), RPL27A(1), RPL3(1), RPL30(1), RPL38(1), RPL3L(3), RPL7(2), RPS10(1), RPS13(1), RPS2(1), RPS20(1), RPS24(1), RPS27(1), RPS29(1), RPS5(1), RPS6(1), RPS7(1), RPSA(1)	3477754	34	23	34	20	19	3	3	7	2	0	0.654	1.000	1.000
520	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	FOS(1), GRB2(2), IL6R(2), IL6ST(4), JAK1(4), JAK2(6), JAK3(5), JUN(1), MAP2K1(3), MAPK3(1), PTPN11(3), RAF1(2), SOS1(4), SRF(1), STAT3(6)	3647694	45	23	44	26	26	5	2	8	4	0	0.778	1.000	1.000
521	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(1), CAT(3), GH1(1), GHR(14), IGF1(6), IGF1R(5), PIK3CA(2), PIK3R1(2)	2038530	34	23	34	20	27	2	0	3	2	0	0.652	1.000	1.000
522	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(1), B4GALT2(2), B4GALT3(1), B4GALT5(1), DDOST(1), DPAGT1(1), DPM1(1), FUT8(4), MAN1A1(8), MAN1B1(2), MGAT3(8), MGAT4A(5), MGAT5(1), RPN2(2), ST6GAL1(4)	3076368	43	23	42	31	30	4	0	3	6	0	0.787	1.000	1.000
523	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(3), HS3ST1(6), HS3ST2(6), HS3ST3B1(2), XYLT1(8), XYLT2(1)	976625	26	22	26	19	18	3	0	2	3	0	0.549	1.000	1.000
524	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(1), JUN(1), MAPK3(1), OPRK1(14), POLR2A(8), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3)	1974028	38	22	38	29	30	1	2	3	2	0	0.838	1.000	1.000
525	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	EPO(4), EPOR(1), FOS(1), GRB2(2), JAK2(6), JUN(1), MAP2K1(3), MAPK3(1), PLCG1(4), PTPN6(1), RAF1(2), SOS1(4), STAT5A(2), STAT5B(2)	3271132	34	22	33	21	21	1	3	6	3	0	0.793	1.000	1.000
526	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(3), HS3ST1(6), HS3ST2(6), HS3ST3B1(2), XYLT1(8), XYLT2(1)	976625	26	22	26	19	18	3	0	2	3	0	0.549	1.000	1.000
527	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT2(2), B3GNT7(3), B4GALT2(2), B4GALT3(1), CHST1(7), CHST2(1), CHST4(6), CHST6(4), FUT8(4), ST3GAL1(5)	1919257	36	22	35	17	27	6	2	0	1	0	0.0957	1.000	1.000
528	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(9), AMT(1), ATIC(1), FTCD(1), GART(5), MTFMT(1), MTHFD1(6), MTHFD2(2), MTHFR(1), MTR(5), SHMT2(2), TYMS(1)	2920068	35	22	35	22	22	3	0	5	5	0	0.735	1.000	1.000
529	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(4), CLOCK(2), CRY1(3), CRY2(1), CSNK1D(1), CSNK1E(3), NPAS2(3), PER1(2), PER2(9), PER3(6)	2617045	34	22	34	21	24	3	1	3	3	0	0.783	1.000	1.000
530	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(2), ARFGAP3(1), ARFGEF2(6), CLTA(1), CLTB(1), COPA(3), GBF1(7), GPLD1(13)	2528463	34	21	34	21	24	2	0	5	3	0	0.784	1.000	1.000
531	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(1), CCR5(4), CXCL12(1), FOS(1), GNAQ(1), JUN(1), MAPK14(4), PLCG1(4), PRKCA(5), PTK2B(7), SYT1(11)	2132477	40	21	40	32	28	2	1	5	4	0	0.895	1.000	1.000
532	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(1), GRB2(2), MAPK1(2), MAPK3(1), MAPK7(2), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), NTRK1(9), PIK3CA(2), PIK3R1(2), PLCG1(4), RPS6KA1(2)	2902220	35	21	35	30	28	3	1	2	1	0	0.953	1.000	1.000
533	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(1), KHK(1), LCT(24), MPI(1), PGM1(2), PYGL(2), PYGM(6), TREH(1)	2026842	38	21	38	36	31	3	0	2	2	0	0.899	1.000	1.000
534	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GALNS(1), GLB1(5), GUSB(2), HEXA(4), HEXB(2), IDS(3), IDUA(3), LCT(24), NAGLU(2)	2196414	46	21	46	27	34	4	0	5	3	0	0.564	1.000	1.000
535	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(2), CHPT1(1), HEMK1(1), LCMT1(3), METTL2B(5), PCYT1A(2), PCYT1B(2), PRMT2(1), PRMT3(3), PRMT5(3), PRMT6(1), PRMT7(1), PRMT8(7)	2161418	32	21	31	14	21	4	2	2	3	0	0.243	1.000	1.000
536	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(2), B3GALNT1(4), B3GALT5(1), FUT1(3), FUT2(1), FUT9(13), GBGT1(1), HEXA(4), HEXB(2), ST3GAL1(5)	1649004	36	21	36	22	26	3	2	5	0	0	0.494	1.000	1.000
537	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(13), CD3D(4), CD3E(2), CD4(3), CD58(1), CD8A(1), CSF3(1), IL3(2), IL8(1), KITLG(6)	945217	34	21	32	21	25	1	1	4	3	0	0.548	1.000	1.000
538	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(4), CAMK1G(8), HDAC9(24), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2)	1137003	44	21	41	21	35	5	0	3	1	0	0.303	1.000	1.000
539	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(5), GAD1(6), HDC(8), PNMT(3), TH(6), TPH1(1)	918150	29	21	29	17	24	1	1	1	2	0	0.306	1.000	1.000
540	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(9), AMT(1), ATIC(1), GART(5), MTHFD1(6), MTHFD2(2), MTHFR(1), MTR(5), SHMT2(2), TYMS(1)	2757369	33	21	33	21	20	3	0	5	5	0	0.752	1.000	1.000
541	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(12), EP300(7), ESR1(2), MAPK1(2), MAPK3(1), PELP1(8)	2252584	32	21	32	15	24	3	1	2	2	0	0.464	1.000	1.000
542	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), AP2A1(1), BTK(6), EEA1(1), GSK3B(1), LYN(1), PDPK1(1), PFKL(2), PLCG1(4), PRKCE(3), PRKCZ(1), RAC1(7), RPS6KB1(1), VAV2(3)	3792391	33	21	30	24	21	1	2	3	6	0	0.735	1.000	1.000
543	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(1), CASP9(2), CHUK(1), H2AFX(1), MAP2K1(3), MAPK3(1), NFKB1(1), PIK3CA(2), PIK3R1(2), RAC1(7), RAF1(2), RALBP1(1), RALGDS(3), RELA(1)	2898419	28	21	24	23	22	4	0	2	0	0	0.923	1.000	1.000
544	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(4), F13B(13), HSD17B2(6), HSD17B3(5), HSD17B4(3), HSD3B1(1), HSD3B2(9)	1227220	41	21	41	20	31	1	3	2	3	1	0.214	1.000	1.000
545	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(12), PRKACB(2), PRKACG(5), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(3), PRKCA(5)	1452995	31	20	31	17	25	1	1	2	2	0	0.594	1.000	1.000
546	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(1), CASP9(2), CHUK(1), GH1(1), GHR(14), NFKB1(1), NFKBIA(1), PDPK1(1), PIK3CA(2), PIK3R1(2), PPP2CA(1), RELA(1)	2146027	28	20	28	24	21	2	2	1	2	0	0.975	1.000	1.000
547	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(3), ANKRD1(1), CYR61(1), DUSP14(1), IFNG(2), IL18(2), IL1A(2), IL1R1(6), MYOG(2), NR4A3(5), WDR1(2)	1633937	27	20	26	14	18	1	0	2	6	0	0.587	1.000	1.000
548	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAP3K14(1), MAPK14(4), NFKB1(1), RELA(1), TNFRSF13B(6), TNFRSF17(3), TRAF2(1), TRAF3(3), TRAF5(4), TRAF6(2)	2210837	27	20	27	17	21	1	0	3	2	0	0.749	1.000	1.000
549	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(3), FOS(1), FYN(4), JUN(1), MAPK14(4), THBS1(15)	1140650	28	20	28	20	15	1	2	6	4	0	0.927	1.000	1.000
550	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GCK(8), GFPT1(1), GNE(2), HEXA(4), HEXB(2), HK1(1), HK2(4), HK3(10), PGM3(1), UAP1(1)	2610904	34	19	33	20	24	2	1	4	3	0	0.601	1.000	1.000
551	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), BCL2(2), CASP8(1), CYCS(1), MAP2K1(3), MAP2K4(3), MAPK1(2), MAPK3(1), NFKB1(1), NSMAF(3), RAF1(2), RELA(1), RIPK1(1), SMPD1(1), TNFRSF1A(2), TRAF2(1)	3130824	26	19	25	20	20	3	2	1	0	0	0.887	1.000	1.000
552	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP51A1(1), DHCR24(1), DHCR7(5), FDPS(2), GGCX(2), HMGCR(7), LSS(2), MVK(1), NQO1(1), NSDHL(2), PMVK(1), SC4MOL(3), SQLE(1)	2966127	29	19	28	15	16	4	1	5	3	0	0.461	1.000	1.000
553	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), BLVRB(1), HMOX1(1), IL10(1), IL10RA(4), IL10RB(2), IL1A(2), JAK1(4), STAT1(2), STAT3(6), STAT5A(2), TNF(1)	1880252	27	19	27	14	15	3	3	2	4	0	0.299	1.000	1.000
554	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	FOS(1), GRB2(2), JUN(1), KLK2(1), MAP2K1(3), MAPK3(1), NGFR(6), PIK3CA(2), PIK3R1(2), PLCG1(4), RAF1(2), SOS1(4)	2919311	29	19	28	22	22	3	0	2	2	0	0.935	1.000	1.000
555	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(4), IFNAR2(3), IFNB1(4), NFKB1(1), RELA(1), TNFRSF11A(3), TNFSF11(3), TRAF6(2)	1703769	22	19	22	18	19	0	0	1	2	0	0.946	1.000	1.000
556	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(1), CREBBP(12), EP300(7), HDAC3(3), IKBKB(2), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF6(2)	3433912	35	19	35	18	23	4	3	2	3	0	0.576	1.000	1.000
557	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ASL(2), CKM(1), CKMT1A(1), CKMT2(5), CPS1(12), GAMT(2), GATM(1), GLUD1(1), OAT(1), ODC1(2), OTC(2), SMS(1)	2647476	31	19	31	16	21	4	3	2	1	0	0.395	1.000	1.000
558	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(13), GNA12(2), PRKACB(2), PRKACG(5), PRKAG1(1), PRKAR2A(1), PRKAR2B(3)	1554169	27	18	27	14	23	1	0	2	1	0	0.449	1.000	1.000
559	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(3), EGR1(1), KLK2(1), MAP2K1(3), MAP2K2(2), MAPK1(2), MAPK3(1), NGFR(6), RAF1(2)	1244694	21	18	20	14	14	2	1	1	3	0	0.582	1.000	1.000
560	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(1), DHCR7(5), FDPS(2), HMGCR(7), HMGCS1(1), LSS(2), MVK(1), NSDHL(2), PMVK(1), SC4MOL(3), SQLE(1)	2025307	26	18	25	10	15	4	0	4	3	0	0.247	1.000	1.000
561	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(6), CDO1(2), CSAD(2), GAD1(6), GAD2(3), GGT1(3)	869298	22	18	21	14	14	2	1	4	1	0	0.648	1.000	1.000
562	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(2), MYST3(9), MYST4(11), NAT6(2), PNPLA3(1), SH3GLB1(1)	2569914	34	18	33	27	22	5	1	4	2	0	0.983	1.000	1.000
563	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(1), GRB2(2), IGF1R(5), IRS1(2), MAP2K1(3), MAPK1(2), MAPK3(1), PIK3CA(2), PIK3R1(2), RAF1(2), SOS1(4)	2923948	26	18	25	14	19	3	1	2	1	0	0.609	1.000	1.000
564	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), GRB2(2), IL2RG(2), IL4(1), IL4R(5), IRS1(2), JAK1(4), JAK3(5), RPS6KB1(1), STAT6(2)	2266975	25	18	25	14	16	2	2	2	3	0	0.627	1.000	1.000
565	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(7), CD4(3), HLA-DRA(5), IL1B(2), IL4(1), IL5(4), IL5RA(7)	822463	29	18	28	24	23	1	0	2	3	0	0.742	1.000	1.000
566	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(9), MBTPS1(3), SCAP(4), SREBF1(2), SREBF2(6)	1818366	25	18	25	17	16	2	2	2	3	0	0.750	1.000	1.000
567	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(4), CDKN1A(1), EPO(4), EPOR(1), GRIN1(6), JAK2(6), NFKB1(1), NFKBIA(1), RELA(1)	1926613	25	17	25	13	11	2	4	3	5	0	0.658	1.000	1.000
568	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(4), FARSB(2), GOT1(4), GOT2(2), PAH(3), TAT(10), YARS2(1)	1343645	26	17	25	15	19	2	2	2	1	0	0.493	1.000	1.000
569	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	SEC22B(3), SNAP25(5), STX11(1), STX16(2), STX17(1), STX19(1), STX5(1), STX6(1), TSNARE1(2), VAMP4(1), VAMP7(2), VAMP8(1), VTI1A(1), VTI1B(1)	2542826	23	17	22	13	15	1	0	4	3	0	0.505	1.000	1.000
570	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(2), IL13RA2(1), IL4R(5), JAK1(4), JAK2(6), TYK2(3)	1607371	23	17	23	12	15	1	2	3	2	0	0.562	1.000	1.000
571	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(2), IL13RA2(1), IL4R(5), JAK1(4), JAK2(6), TYK2(3)	1607371	23	17	23	12	15	1	2	3	2	0	0.562	1.000	1.000
572	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(1), GRB2(2), KLK2(1), NTRK1(9), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(5), SOS1(4)	2385523	30	17	30	20	22	3	1	2	2	0	0.846	1.000	1.000
573	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH9A1(2)	1223045	23	16	23	12	12	4	1	2	4	0	0.363	1.000	1.000
574	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH9A1(2)	1223045	23	16	23	12	12	4	1	2	4	0	0.363	1.000	1.000
575	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(3), ARHGAP5(7), ARHGDIB(1), CASP1(3), CASP10(3), CASP8(1), CASP9(2), CYCS(1), GZMB(1), JUN(1), PRF1(5)	1994238	28	16	28	14	20	3	1	3	1	0	0.542	1.000	1.000
576	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), ACO2(1), CS(1), HAO1(4), HAO2(7), HYI(1), MDH1(1), MDH2(1), MTHFD1(6), MTHFD2(2)	1970372	25	16	25	15	16	1	2	3	3	0	0.603	1.000	1.000
577	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(5), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(2), PON1(8), PON2(1), PON3(4), RDH12(1), RDH13(3)	1393074	32	16	31	20	24	2	0	3	3	0	0.484	1.000	1.000
578	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(8), HK1(1), HK2(4), HK3(10), IMPA1(1), IMPA2(1), ISYNA1(1), PGM1(2), PGM3(1), TGDS(1)	1791327	30	16	29	18	22	2	0	2	4	0	0.507	1.000	1.000
579	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(4), B3GALT1(8), B3GALT2(1), B3GALT5(1), B3GNT5(1), FUT1(3), FUT2(1), FUT3(3)	1105506	22	16	22	19	18	2	0	1	1	0	0.815	1.000	1.000
580	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), ACO2(1), CS(1), HAO1(4), HAO2(7), HYI(1), MDH1(1), MDH2(1), MTHFD1(6), MTHFD2(2)	2063411	25	16	25	17	16	1	2	3	3	0	0.729	1.000	1.000
581	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(4), CHST12(1), CHST13(1), PAPSS1(1), PAPSS2(2), SULT1A1(8), SULT1E1(7), SULT2A1(4), SULT2B1(5), SUOX(2)	1401942	35	16	35	21	27	2	0	3	3	0	0.507	1.000	1.000
582	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(1), ESR1(2), GREB1(15), HSPB1(1), HSPB2(1), MTA1(1), MTA3(1), TUBA8(1)	1637287	24	16	23	15	17	2	2	1	2	0	0.490	1.000	1.000
583	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(4), JAK2(6), JAK3(5), MAPK1(2), MAPK3(1), STAT3(6), TYK2(3)	1784850	27	16	27	21	16	3	3	3	2	0	0.866	1.000	1.000
584	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(3), NRF1(3), UBE2D3(2), UBE2I(1), UBE2J1(1), UBE2J2(3), UBE2L6(1), UBE2M(1), UBE2S(1), UBE3A(5)	1629943	21	16	20	10	17	3	0	1	0	0	0.487	1.000	1.000
585	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR2(3), IFNB1(4), JAK1(4), STAT1(2), STAT2(5), TYK2(3)	1659071	21	15	21	13	14	1	1	3	2	0	0.700	1.000	1.000
586	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(4), CAPN1(1), CDK5(3), CSNK1A1(1), CSNK1D(1), GSK3B(1), MAPT(4), PPP2CA(1)	1382889	16	15	16	10	11	0	1	1	3	0	0.755	1.000	1.000
587	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(8), HK1(1), HK2(4), HK3(10), IMPA1(1), PGM1(2), PGM3(1), TGDS(1)	1575045	28	15	27	16	22	2	0	1	3	0	0.455	1.000	1.000
588	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), IKBKAP(3), IKBKB(2), LTA(2), MAP3K14(1), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(1), TNFAIP3(1), TNFRSF1B(1), TRAF1(4), TRAF2(1), TRAF3(3)	3428466	23	15	23	27	17	1	1	2	2	0	0.997	1.000	1.000
589	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(1), ADORA2A(1), ADORA2B(1), ADORA3(10), P2RY1(1), P2RY2(3), P2RY6(1)	917392	18	14	18	18	13	2	0	1	2	0	0.582	1.000	1.000
590	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO3(1), GOT1(4), GOT2(2), PAH(3), TAT(10)	1287663	22	14	22	13	19	0	2	1	0	0	0.411	1.000	1.000
591	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(4), FUT1(3), FUT2(1), FUT3(3), FUT5(6), FUT6(1)	770236	18	13	18	13	12	2	1	0	3	0	0.503	1.000	1.000
592	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), IKBKAP(3), IKBKB(2), MAP3K14(1), NFKB1(1), NFKBIA(1), RELA(1), TNFAIP3(1), TRAF3(3), TRAF6(2)	2776403	16	13	16	18	11	1	1	2	1	0	0.993	1.000	1.000
593	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(7), EIF2AK4(6), EIF2B5(1), EIF2S1(1), GSK3B(1), PPP1CA(1)	1795655	17	13	16	10	11	0	0	4	2	0	0.849	1.000	1.000
594	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(5), ENO1(2), GPI(2), HK1(1), PFKL(2), PGK1(1), PKLR(6)	1411295	19	13	19	12	14	0	1	1	3	0	0.388	1.000	1.000
595	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(5), CDC25B(1), CDC25C(3), CSK(1), GRB2(2), PRKCA(5), PTPRA(2)	1432602	19	13	19	14	13	2	1	1	2	0	0.833	1.000	1.000
596	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	FOS(1), JUN(1), KEAP1(1), MAPK1(2), MAPK14(4), NFE2L2(1), PRKCA(5)	1364837	15	12	15	12	8	1	0	3	3	0	0.937	1.000	1.000
597	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1), BDH1(2), HMGCL(2), HMGCS1(1), HMGCS2(11), OXCT1(3), OXCT2(2)	1100438	22	12	21	10	16	3	0	2	1	0	0.406	1.000	1.000
598	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(4), HGD(10)	347204	14	12	14	12	10	2	2	0	0	0	0.855	1.000	1.000
599	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(5), ACO1(1), ACO2(1), ACSS2(3), FH(3), IDH1(6), MDH1(1), MDH2(1)	2063866	21	12	18	14	15	0	2	2	2	0	0.666	1.000	1.000
600	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(3), PLCG1(4), PRKCA(5), PTK2B(7)	1042770	19	12	19	16	15	2	0	0	2	0	0.757	1.000	1.000
601	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(6), MTHFD2(2), POLD1(2), POLG(4), PRPS2(1), RRM1(2)	1906408	17	12	17	10	9	2	1	2	3	0	0.627	1.000	1.000
602	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(3), HLA-DRA(5), IL10(1), IL2(4), IL4(1)	606585	14	11	14	15	10	1	0	1	2	0	0.906	1.000	1.000
603	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(3), ALDH3A2(2), ALDH7A1(2), ALDH9A1(2), MIOX(3)	1302700	17	11	17	14	10	3	1	0	3	0	0.807	1.000	1.000
604	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(3), APOBEC1(3), APOBEC2(3), APOBEC3A(1), APOBEC3B(1), APOBEC3C(2), APOBEC3G(1)	1140250	14	11	14	9	10	2	2	0	0	0	0.659	1.000	1.000
605	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(5), GOT1(4), GOT2(2), TAT(10), TYR(2)	725401	23	11	23	16	19	0	2	1	1	0	0.761	1.000	1.000
606	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(2), PTK2B(7), SOS1(4)	1351901	13	10	13	10	11	0	0	1	1	0	0.888	1.000	1.000
607	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ3(2), COQ6(1), NDUFA12(1), NDUFA13(5)	613192	10	10	9	7	7	1	2	0	0	0	0.836	1.000	1.000
608	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(13), PSAT1(1)	749043	14	10	13	11	13	1	0	0	0	0	0.804	1.000	1.000
609	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CSF1(7), LDLR(9), LPL(2)	826479	18	10	18	13	15	3	0	0	0	0	0.665	1.000	1.000
610	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(7), IL1B(2), MST1(1), MST1R(4), TNF(1)	1008413	15	10	15	13	11	2	0	0	2	0	0.849	1.000	1.000
611	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(1), DLL1(2), FURIN(2), NOTCH1(3)	1418128	8	8	8	12	4	2	1	1	0	0	0.984	1.000	1.000
612	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(3), HLA-DRA(5)	362573	8	7	8	12	6	1	0	1	0	0	0.976	1.000	1.000
613	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(4), CD3D(4), CD3E(2), CD4(3)	494848	13	7	13	15	9	1	0	2	1	0	0.941	1.000	1.000
614	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(4), GLS(1), GLUD1(1), OAT(1), PRODH(1)	834276	8	5	8	11	3	2	2	1	0	0	0.991	1.000	1.000
615	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(10)	281945	10	4	10	8	8	1	1	0	0	0	0.790	1.000	1.000
616	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2)	327266	2	2	2	3	1	0	0	1	0	0	0.953	1.000	1.000
